ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.98667114
2	ribosomal small subunit assembly (GO:0000028)	5.39266246
3	cytidine metabolic process (GO:0046087)	4.98369291
4	cytidine catabolic process (GO:0006216)	4.98369291
5	cytidine deamination (GO:0009972)	4.98369291
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.64412961
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.35324754
8	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.32325362
9	ATP synthesis coupled proton transport (GO:0015986)	4.28560463
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.28560463
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.17203061
12	protein neddylation (GO:0045116)	4.04858132
13	respiratory electron transport chain (GO:0022904)	3.83273057
14	electron transport chain (GO:0022900)	3.81098595
15	protein complex biogenesis (GO:0070271)	3.53985098
16	regulation of regulatory T cell differentiation (GO:0045589)	3.48914563
17	viral transcription (GO:0019083)	3.41977759
18	positive thymic T cell selection (GO:0045059)	3.36986927
19	translational termination (GO:0006415)	3.31858735
20	sequestering of actin monomers (GO:0042989)	3.30314065
21	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.29653435
22	platelet dense granule organization (GO:0060155)	3.29383678
23	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.28570130
24	regulation of isotype switching to IgG isotypes (GO:0048302)	3.25990592
25	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.25046209
26	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.22562469
27	cotranslational protein targeting to membrane (GO:0006613)	3.21727824
28	protein targeting to ER (GO:0045047)	3.21261367
29	positive T cell selection (GO:0043368)	3.20446703
30	actin nucleation (GO:0045010)	3.11881988
31	mitochondrial respiratory chain complex assembly (GO:0033108)	3.10621095
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.08311319
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.08311319
34	NADH dehydrogenase complex assembly (GO:0010257)	3.08311319
35	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.08134089
36	protein localization to endoplasmic reticulum (GO:0070972)	3.05685968
37	translational elongation (GO:0006414)	3.01898083
38	negative regulation of T cell apoptotic process (GO:0070233)	3.01472807
39	respiratory chain complex IV assembly (GO:0008535)	2.98272100
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.97480943
41	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.97480943
42	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.96484970
43	regulation of chronic inflammatory response (GO:0002676)	2.95433367
44	axoneme assembly (GO:0035082)	2.95406242
45	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.94540995
46	cytochrome complex assembly (GO:0017004)	2.93085347
47	water-soluble vitamin biosynthetic process (GO:0042364)	2.92522599
48	negative T cell selection (GO:0043383)	2.89244135
49	GPI anchor metabolic process (GO:0006505)	2.85563096
50	hydrogen ion transmembrane transport (GO:1902600)	2.85186849
51	cellular ketone body metabolic process (GO:0046950)	2.79931459
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.79327096
53	positive regulation of calcium-mediated signaling (GO:0050850)	2.75751704
54	GPI anchor biosynthetic process (GO:0006506)	2.74745864
55	regulation of alpha-beta T cell proliferation (GO:0046640)	2.74645114
56	S-adenosylmethionine metabolic process (GO:0046500)	2.74397256
57	T cell receptor signaling pathway (GO:0050852)	2.73768288
58	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.73114546
59	termination of RNA polymerase III transcription (GO:0006386)	2.73114546
60	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.72345414
61	proton transport (GO:0015992)	2.72343171
62	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.71867793
63	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.70945085
64	mast cell activation (GO:0045576)	2.69508151
65	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.69018239
66	purine deoxyribonucleotide catabolic process (GO:0009155)	2.67577121
67	hydrogen transport (GO:0006818)	2.67261161
68	regulation of B cell receptor signaling pathway (GO:0050855)	2.66773638
69	indolalkylamine metabolic process (GO:0006586)	2.66208281
70	lymphocyte costimulation (GO:0031294)	2.64986208
71	mannosylation (GO:0097502)	2.64412432
72	regulation of cellular amino acid metabolic process (GO:0006521)	2.63321669
73	T cell costimulation (GO:0031295)	2.62928882
74	T cell migration (GO:0072678)	2.62727692
75	response to interferon-beta (GO:0035456)	2.61821954
76	behavioral response to nicotine (GO:0035095)	2.61540975
77	regulation of T cell receptor signaling pathway (GO:0050856)	2.61248100
78	positive regulation of defense response to virus by host (GO:0002230)	2.57738974
79	preassembly of GPI anchor in ER membrane (GO:0016254)	2.57730901
80	positive regulation of interleukin-8 secretion (GO:2000484)	2.56409442
81	ribosomal large subunit biogenesis (GO:0042273)	2.53758094
82	cellular response to interleukin-15 (GO:0071350)	2.51863130
83	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.51795110
84	ketone body metabolic process (GO:1902224)	2.51537417
85	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.51435829
86	ATP biosynthetic process (GO:0006754)	2.51279712
87	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.50168637
88	negative thymic T cell selection (GO:0045060)	2.50058343
89	translation (GO:0006412)	2.50042567
90	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.49847801
91	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.49072625
92	positive regulation of tolerance induction (GO:0002645)	2.48849299
93	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.48148237
94	iron-sulfur cluster assembly (GO:0016226)	2.46978867
95	metallo-sulfur cluster assembly (GO:0031163)	2.46978867
96	regulation of interleukin-8 secretion (GO:2000482)	2.45691268
97	GTP biosynthetic process (GO:0006183)	2.45313416
98	cellular protein complex disassembly (GO:0043624)	2.44559521
99	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.43520896
100	negative regulation of heart rate (GO:0010459)	2.42931126

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.81381023
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.48300686
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.16466031
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.13915438
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.85729830
6	VDR_22108803_ChIP-Seq_LS180_Human	2.70268920
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.56626067
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.47814128
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.39755301
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.37197132
11	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.36115791
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.31240422
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.28703160
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.26230571
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.22730532
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.12517937
17	EZH2_22144423_ChIP-Seq_EOC_Human	1.98990431
18	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.98265738
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.97098953
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.94141989
21	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.91857309
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.78142610
23	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.77567143
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.75781051
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.74601986
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74105302
27	EWS_26573619_Chip-Seq_HEK293_Human	1.68188754
28	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.66470274
29	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.55589416
30	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.55589416
31	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.54919768
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53606139
33	GATA3_26560356_Chip-Seq_TH2_Human	1.53176729
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.51732909
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.51010697
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48630654
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.48346746
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.47580513
39	AR_20517297_ChIP-Seq_VCAP_Human	1.46590594
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.46025030
41	MYB_26560356_Chip-Seq_TH2_Human	1.45650582
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.45010949
43	P300_19829295_ChIP-Seq_ESCs_Human	1.43988000
44	FUS_26573619_Chip-Seq_HEK293_Human	1.43395486
45	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.41647231
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39526039
47	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.38978142
48	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.38755224
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34954333
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34954333
51	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.33981629
52	TAF15_26573619_Chip-Seq_HEK293_Human	1.33591047
53	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.33259811
54	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.32197255
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31023059
56	NCOR_22424771_ChIP-Seq_293T_Human	1.30454327
57	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.29507463
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26291293
59	RUNX_20019798_ChIP-Seq_JUKART_Human	1.25895952
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.24401654
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24401654
62	GATA3_27048872_Chip-Seq_THYMUS_Human	1.23704884
63	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.22565175
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21879767
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20145858
66	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18974579
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18859277
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.18446246
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.16195088
70	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16152114
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16013095
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15765891
73	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.15486743
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14942392
75	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13909159
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13315995
77	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.11874377
78	HTT_18923047_ChIP-ChIP_STHdh_Human	1.10079540
79	GBX2_23144817_ChIP-Seq_PC3_Human	1.09855802
80	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.09210557
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08175961
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.08135853
83	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06158373
84	MYC_19829295_ChIP-Seq_ESCs_Human	1.05599236
85	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05372711
86	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05067065
87	ERG_20517297_ChIP-Seq_VCAP_Human	1.04974121
88	BCAT_22108803_ChIP-Seq_LS180_Human	1.04903923
89	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01516172
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00984409
91	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.00896462
92	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00602714
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98999250
94	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98476999
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98419121
96	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.96666816
97	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.95337313
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.94813314
99	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.92107170
100	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.91535739

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.48527357
2	MP0001835_abnormal_antigen_presentation	3.36396918
3	MP0009379_abnormal_foot_pigmentation	3.16427528
4	MP0006072_abnormal_retinal_apoptosis	2.89242060
5	MP0009785_altered_susceptibility_to	2.41925372
6	MP0005645_abnormal_hypothalamus_physiol	2.28625296
7	MP0003646_muscle_fatigue	2.04126194
8	MP0006292_abnormal_olfactory_placode	2.02077990
9	MP0001800_abnormal_humoral_immune	1.95395307
10	MP0005551_abnormal_eye_electrophysiolog	1.93199668
11	MP0002148_abnormal_hypersensitivity_rea	1.88500791
12	MP0003011_delayed_dark_adaptation	1.87252421
13	MP0008872_abnormal_physiological_respon	1.86718309
14	MP0008877_abnormal_DNA_methylation	1.85028468
15	MP0002102_abnormal_ear_morphology	1.82391725
16	MP0005000_abnormal_immune_tolerance	1.82351715
17	MP0002837_dystrophic_cardiac_calcinosis	1.81238291
18	MP0005646_abnormal_pituitary_gland	1.72415809
19	MP0002166_altered_tumor_susceptibility	1.71996007
20	MP0009333_abnormal_splenocyte_physiolog	1.70853433
21	MP0003195_calcinosis	1.69960226
22	MP0008875_abnormal_xenobiotic_pharmacok	1.69242694
23	MP0005253_abnormal_eye_physiology	1.67653460
24	MP0001873_stomach_inflammation	1.66986195
25	MP0003880_abnormal_central_pattern	1.64395304
26	MP0003763_abnormal_thymus_physiology	1.61138899
27	MP0002723_abnormal_immune_serum	1.59298560
28	MP0005075_abnormal_melanosome_morpholog	1.56261730
29	MP0002138_abnormal_hepatobiliary_system	1.55220278
30	MP0005387_immune_system_phenotype	1.54962160
31	MP0001790_abnormal_immune_system	1.54962160
32	MP0004147_increased_porphyrin_level	1.53420614
33	MP0000685_abnormal_immune_system	1.52121028
34	MP0002420_abnormal_adaptive_immunity	1.50771747
35	MP0003806_abnormal_nucleotide_metabolis	1.50180862
36	MP0001819_abnormal_immune_cell	1.48594642
37	MP0003866_abnormal_defecation	1.45023164
38	MP0000372_irregular_coat_pigmentation	1.44908594
39	MP0002006_tumorigenesis	1.42429246
40	MP0002452_abnormal_antigen_presenting	1.41781304
41	MP0003878_abnormal_ear_physiology	1.40644523
42	MP0005377_hearing/vestibular/ear_phenot	1.40644523
43	MP0005025_abnormal_response_to	1.35543430
44	MP0008995_early_reproductive_senescence	1.35123773
45	MP0001905_abnormal_dopamine_level	1.34794901
46	MP0002876_abnormal_thyroid_physiology	1.34629933
47	MP0001968_abnormal_touch/_nociception	1.33139354
48	MP0004885_abnormal_endolymph	1.27914297
49	MP0002163_abnormal_gland_morphology	1.21524310
50	MP0001986_abnormal_taste_sensitivity	1.20614507
51	MP0006082_CNS_inflammation	1.20458235
52	MP0003786_premature_aging	1.20314213
53	MP0001485_abnormal_pinna_reflex	1.20302333
54	MP0009764_decreased_sensitivity_to	1.19995397
55	MP0004142_abnormal_muscle_tone	1.18697767
56	MP0001529_abnormal_vocalization	1.18071194
57	MP0005084_abnormal_gallbladder_morpholo	1.17303783
58	MP0001984_abnormal_olfaction	1.15894641
59	MP0006276_abnormal_autonomic_nervous	1.14954122
60	MP0001919_abnormal_reproductive_system	1.14715017
61	MP0005389_reproductive_system_phenotype	1.13580282
62	MP0004145_abnormal_muscle_electrophysio	1.12240300
63	MP0000716_abnormal_immune_system	1.11390123
64	MP0001501_abnormal_sleep_pattern	1.10908612
65	MP0002277_abnormal_respiratory_mucosa	1.08563266
66	MP0004043_abnormal_pH_regulation	1.06866344
67	MP0010155_abnormal_intestine_physiology	1.06199796
68	MP0005379_endocrine/exocrine_gland_phen	1.05617730
69	MP0002398_abnormal_bone_marrow	1.04147761
70	MP0002693_abnormal_pancreas_physiology	1.03897002
71	MP0002272_abnormal_nervous_system	1.02160641
72	MP0002736_abnormal_nociception_after	1.00533814
73	MP0001764_abnormal_homeostasis	0.98256598
74	MP0005636_abnormal_mineral_homeostasis	0.97683615
75	MP0001845_abnormal_inflammatory_respons	0.97296981
76	MP0010386_abnormal_urinary_bladder	0.97234828
77	MP0003787_abnormal_imprinting	0.96036127
78	MP0006036_abnormal_mitochondrial_physio	0.95057184
79	MP0009745_abnormal_behavioral_response	0.92665412
80	MP0002638_abnormal_pupillary_reflex	0.92317517
81	MP0000631_abnormal_neuroendocrine_gland	0.90470939
82	MP0000689_abnormal_spleen_morphology	0.90283525
83	MP0002095_abnormal_skin_pigmentation	0.89594499
84	MP0004742_abnormal_vestibular_system	0.89441071
85	MP0001765_abnormal_ion_homeostasis	0.89392015
86	MP0002933_joint_inflammation	0.87370337
87	MP0005085_abnormal_gallbladder_physiolo	0.85777340
88	MP0005410_abnormal_fertilization	0.85054601
89	MP0002405_respiratory_system_inflammati	0.84920865
90	MP0001486_abnormal_startle_reflex	0.84719704
91	MP0008469_abnormal_protein_level	0.81048229
92	MP0003724_increased_susceptibility_to	0.80186825
93	MP0001970_abnormal_pain_threshold	0.79582470
94	MP0002429_abnormal_blood_cell	0.79579674
95	MP0002722_abnormal_immune_system	0.77209661
96	MP0002234_abnormal_pharynx_morphology	0.76317144
97	MP0002160_abnormal_reproductive_system	0.73749366
98	MP0002419_abnormal_innate_immunity	0.71921178
99	MP0001853_heart_inflammation	0.70875160
100	MP0003137_abnormal_impulse_conducting	0.70798141

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.32637954
2	Mitochondrial inheritance (HP:0001427)	4.13992573
3	Congenital stationary night blindness (HP:0007642)	3.99288386
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.82859624
5	3-Methylglutaconic aciduria (HP:0003535)	3.80969474
6	IgG deficiency (HP:0004315)	3.67023496
7	Progressive macrocephaly (HP:0004481)	3.66763984
8	Increased hepatocellular lipid droplets (HP:0006565)	3.60044148
9	Hepatocellular necrosis (HP:0001404)	3.58659804
10	Acute encephalopathy (HP:0006846)	3.56046320
11	Severe combined immunodeficiency (HP:0004430)	3.54137806
12	Hypoproteinemia (HP:0003075)	3.50077497
13	Increased CSF lactate (HP:0002490)	3.43281771
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.41805460
15	Pancreatic cysts (HP:0001737)	3.31990767
16	Hepatic necrosis (HP:0002605)	3.31411412
17	Lipid accumulation in hepatocytes (HP:0006561)	3.29429696
18	Aplastic anemia (HP:0001915)	3.20659083
19	Abnormality of B cell number (HP:0010975)	3.18976284
20	Thyroiditis (HP:0100646)	3.15881726
21	Elevated erythrocyte sedimentation rate (HP:0003565)	3.13960294
22	Abnormal rod and cone electroretinograms (HP:0008323)	3.11983746
23	Molar tooth sign on MRI (HP:0002419)	3.11172143
24	Abnormality of midbrain morphology (HP:0002418)	3.11172143
25	Increased intramyocellular lipid droplets (HP:0012240)	3.10526079
26	T lymphocytopenia (HP:0005403)	3.01872812
27	Stomatitis (HP:0010280)	3.01717482
28	Abnormality of T cell number (HP:0011839)	2.95079330
29	Congenital, generalized hypertrichosis (HP:0004540)	2.91924081
30	Pancreatic fibrosis (HP:0100732)	2.90582501
31	Cerebral edema (HP:0002181)	2.86298465
32	B lymphocytopenia (HP:0010976)	2.83984040
33	Renal Fanconi syndrome (HP:0001994)	2.81122616
34	Abolished electroretinogram (ERG) (HP:0000550)	2.80307582
35	True hermaphroditism (HP:0010459)	2.78766262
36	Decreased central vision (HP:0007663)	2.69115834
37	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.69095250
38	Exertional dyspnea (HP:0002875)	2.68997671
39	Attenuation of retinal blood vessels (HP:0007843)	2.68492474
40	Optic disc pallor (HP:0000543)	2.68307557
41	Combined immunodeficiency (HP:0005387)	2.63807577
42	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.59857489
43	Increased muscle lipid content (HP:0009058)	2.58754897
44	Methylmalonic acidemia (HP:0002912)	2.46609671
45	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.36715249
46	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.36715249
47	Nephronophthisis (HP:0000090)	2.36325562
48	Abnormality of the prostate (HP:0008775)	2.35224082
49	Abnormality of the renal cortex (HP:0011035)	2.25767701
50	Renal cortical cysts (HP:0000803)	2.25269259
51	Increased IgM level (HP:0003496)	2.25114420
52	Increased serum lactate (HP:0002151)	2.24667573
53	Lactic acidosis (HP:0003128)	2.23571670
54	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.22986194
55	Abnormality of T cells (HP:0002843)	2.22430684
56	Abnormality of eosinophils (HP:0001879)	2.18768049
57	Constricted visual fields (HP:0001133)	2.18763215
58	Abnormal number of erythroid precursors (HP:0012131)	2.16874022
59	Abnormality of cells of the erythroid lineage (HP:0012130)	2.14821044
60	Glycosuria (HP:0003076)	2.10601376
61	Abnormality of urine glucose concentration (HP:0011016)	2.10601376
62	Abnormal albumin level (HP:0012116)	2.05222841
63	Hypoalbuminemia (HP:0003073)	2.05222841
64	Medial flaring of the eyebrow (HP:0010747)	2.04379183
65	Respiratory failure (HP:0002878)	2.03225772
66	Hypothermia (HP:0002045)	2.03045979
67	Methylmalonic aciduria (HP:0012120)	2.01654877
68	Type II lissencephaly (HP:0007260)	2.00059750
69	Panhypogammaglobulinemia (HP:0003139)	1.98204014
70	Reticulocytopenia (HP:0001896)	1.97757944
71	Lethargy (HP:0001254)	1.97416265
72	Generalized aminoaciduria (HP:0002909)	1.96263713
73	Exercise intolerance (HP:0003546)	1.96238509
74	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.95627740
75	Dicarboxylic aciduria (HP:0003215)	1.95627740
76	Pendular nystagmus (HP:0012043)	1.93501678
77	Abnormality of the renal medulla (HP:0100957)	1.92824503
78	Leukodystrophy (HP:0002415)	1.90926293
79	Chronic diarrhea (HP:0002028)	1.89862935
80	Abnormal biliary tract physiology (HP:0012439)	1.89736176
81	Bile duct proliferation (HP:0001408)	1.89736176
82	Severe visual impairment (HP:0001141)	1.89498290
83	Autoimmune hemolytic anemia (HP:0001890)	1.88896251
84	Cystic liver disease (HP:0006706)	1.86604635
85	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.83162192
86	Eosinophilia (HP:0001880)	1.83130504
87	Abnormality of renal resorption (HP:0011038)	1.80691466
88	Type 2 muscle fiber atrophy (HP:0003554)	1.79851178
89	Hyperphosphaturia (HP:0003109)	1.78809909
90	Abnormality of DNA repair (HP:0003254)	1.77894154
91	Ketosis (HP:0001946)	1.77311264
92	Increased corneal curvature (HP:0100692)	1.76970229
93	Keratoconus (HP:0000563)	1.76970229
94	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.76761423
95	Hypomagnesemia (HP:0002917)	1.76206320
96	Absent/shortened dynein arms (HP:0200106)	1.75534942
97	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.75534942
98	Asplenia (HP:0001746)	1.75007969
99	Hypoplasia of the thymus (HP:0000778)	1.74634266
100	Sclerocornea (HP:0000647)	1.73944181

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.18309120
2	KDR	3.33693665
3	BCKDK	2.92721048
4	CDK19	2.92432624
5	MAP4K2	2.81183261
6	TESK2	2.76690211
7	GRK1	2.74119001
8	ADRBK2	2.68655616
9	FRK	2.61880302
10	TAOK3	2.43568246
11	MAP4K1	2.32544054
12	PINK1	2.15036932
13	MAP3K12	2.13296891
14	ITK	2.10595265
15	ZAK	2.10166735
16	NUAK1	2.03391115
17	TLK1	1.88692961
18	VRK2	1.83466214
19	TIE1	1.76399983
20	PASK	1.64444867
21	TEC	1.63980008
22	WNK3	1.41857601
23	WNK4	1.41229690
24	VRK1	1.32948247
25	DAPK2	1.29966379
26	FES	1.28147236
27	SYK	1.23906856
28	LIMK1	1.22009591
29	BMPR2	1.20127906
30	MST4	1.14312438
31	MYLK	1.13745913
32	GRK6	1.12423595
33	OXSR1	1.01490796
34	BTK	1.00938784
35	KIT	1.00909722
36	INSRR	0.99512850
37	IKBKB	0.96239924
38	PRKCQ	0.92714996
39	TRIM28	0.92414005
40	SCYL2	0.91380055
41	LCK	0.89648033
42	DAPK1	0.88021895
43	MAP2K6	0.87956635
44	MUSK	0.87083788
45	STK16	0.86701273
46	CSF1R	0.85062490
47	CSNK1G3	0.84417847
48	EIF2AK3	0.84403451
49	RPS6KA4	0.83892835
50	LYN	0.82911234
51	ERBB3	0.82509145
52	MAP2K7	0.81677261
53	TNK2	0.79785378
54	MAP3K4	0.78923809
55	NME1	0.78135044
56	CAMKK2	0.76623469
57	MAPK13	0.74107852
58	CSNK1G1	0.72568587
59	RPS6KA5	0.69304578
60	MAP3K11	0.67789880
61	OBSCN	0.67499470
62	DYRK2	0.66932078
63	CSNK1G2	0.64430213
64	ZAP70	0.64074156
65	BMPR1B	0.63872586
66	IKBKE	0.60307752
67	ADRBK1	0.59842579
68	CSNK1A1L	0.58324584
69	JAK3	0.57554423
70	CAMKK1	0.56633996
71	CSK	0.56592517
72	GRK7	0.56113241
73	PLK4	0.55086018
74	PIK3CA	0.50029598
75	PHKG1	0.49682860
76	PHKG2	0.49682860
77	PRKCE	0.49454655
78	IGF1R	0.49321804
79	PRKACA	0.48770049
80	DAPK3	0.48181776
81	FLT3	0.46786241
82	PRKCA	0.43946606
83	MAPKAPK3	0.42499333
84	TRPM7	0.42443695
85	STK39	0.41412251
86	CSNK1A1	0.40502260
87	PIK3CG	0.38924119
88	CAMK2A	0.37847095
89	TESK1	0.37533829
90	CSNK2A2	0.35917162
91	ROCK1	0.33567686
92	CAMK1	0.32746405
93	CSNK2A1	0.31106272
94	TBK1	0.27075697
95	PRKCG	0.26558041
96	PAK3	0.26444660
97	PRKCB	0.26417218
98	PRKCH	0.25966595
99	PTK2B	0.25561772
100	MAPK15	0.25362276

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.49200697
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.46096648
3	Allograft rejection_Homo sapiens_hsa05330	3.43673622
4	Primary immunodeficiency_Homo sapiens_hsa05340	3.34508415
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.31874209
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.23892188
7	Proteasome_Homo sapiens_hsa03050	3.13348965
8	Ribosome_Homo sapiens_hsa03010	3.02672925
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.93852755
10	Parkinsons disease_Homo sapiens_hsa05012	2.68569546
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.63674038
12	Protein export_Homo sapiens_hsa03060	2.43409738
13	Antigen processing and presentation_Homo sapiens_hsa04612	2.28086378
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99145755
15	RNA polymerase_Homo sapiens_hsa03020	1.86031135
16	Phototransduction_Homo sapiens_hsa04744	1.83358241
17	Alzheimers disease_Homo sapiens_hsa05010	1.81234070
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.75716552
19	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.74347649
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.73591864
21	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.73079240
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.63537590
23	Huntingtons disease_Homo sapiens_hsa05016	1.60746586
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.56739013
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.56716424
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.41640951
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.19369801
28	Viral myocarditis_Homo sapiens_hsa05416	1.18935333
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.13241419
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.12520821
31	Homologous recombination_Homo sapiens_hsa03440	1.06800487
32	Propanoate metabolism_Homo sapiens_hsa00640	1.06609681
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.05749494
34	RNA degradation_Homo sapiens_hsa03018	1.05398338
35	Butanoate metabolism_Homo sapiens_hsa00650	1.04653587
36	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.02293611
37	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.98116817
38	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.93064301
39	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.89404169
40	Retinol metabolism_Homo sapiens_hsa00830	0.87347849
41	Caffeine metabolism_Homo sapiens_hsa00232	0.87019958
42	Olfactory transduction_Homo sapiens_hsa04740	0.86311414
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.85610936
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.85241703
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82088004
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81924850
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81027617
48	Peroxisome_Homo sapiens_hsa04146	0.80123582
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79290389
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.78452354
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77438527
52	One carbon pool by folate_Homo sapiens_hsa00670	0.71559314
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71054618
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.70923228
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70077250
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69931029
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.69463467
58	Basal transcription factors_Homo sapiens_hsa03022	0.69126545
59	Purine metabolism_Homo sapiens_hsa00230	0.68372531
60	Taste transduction_Homo sapiens_hsa04742	0.67487772
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.67216017
62	Regulation of autophagy_Homo sapiens_hsa04140	0.63301674
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.61250430
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57389249
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.56208865
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.54511346
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.53933730
68	Nicotine addiction_Homo sapiens_hsa05033	0.52762802
69	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.52523229
70	Leishmaniasis_Homo sapiens_hsa05140	0.49460528
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49101499
72	Metabolic pathways_Homo sapiens_hsa01100	0.48079250
73	Sulfur metabolism_Homo sapiens_hsa00920	0.46505180
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43003465
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41146960
76	Mismatch repair_Homo sapiens_hsa03430	0.39907969
77	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.38352000
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.37632385
79	Morphine addiction_Homo sapiens_hsa05032	0.37221678
80	Herpes simplex infection_Homo sapiens_hsa05168	0.34370727
81	Salivary secretion_Homo sapiens_hsa04970	0.31681604
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.30036226
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.28998127
84	Measles_Homo sapiens_hsa05162	0.28715999
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.27536347
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.26125744
87	Spliceosome_Homo sapiens_hsa03040	0.24448617
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.24166372
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.22626977
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.22549188
91	RNA transport_Homo sapiens_hsa03013	0.21686455
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.21516803
93	Serotonergic synapse_Homo sapiens_hsa04726	0.21114548
94	GABAergic synapse_Homo sapiens_hsa04727	0.20694715
95	ABC transporters_Homo sapiens_hsa02010	0.19905862
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.19645903
97	Malaria_Homo sapiens_hsa05144	0.19189254
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.16545317
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.16291207
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.15324490

RPL21P129

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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