ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	serotonin receptor signaling pathway (GO:0007210)	7.55307643
2	negative regulation of interleukin-8 production (GO:0032717)	6.74359771
3	regulation of appetite (GO:0032098)	6.52004953
4	positive regulation of hair cycle (GO:0042635)	6.47042067
5	positive regulation of hair follicle development (GO:0051798)	6.47042067
6	interferon-gamma production (GO:0032609)	6.39483559
7	angiogenesis involved in wound healing (GO:0060055)	5.94010174
8	positive regulation of osteoblast proliferation (GO:0033690)	5.77346697
9	activated T cell proliferation (GO:0050798)	5.48222627
10	negative regulation of calcium ion transport into cytosol (GO:0010523)	5.39562905
11	negative regulation of circadian rhythm (GO:0042754)	5.25539248
12	glycerophospholipid catabolic process (GO:0046475)	5.20063992
13	regulation of Cdc42 GTPase activity (GO:0043088)	5.17751599
14	disruption of cells of other organism (GO:0044364)	4.94808026
15	killing of cells of other organism (GO:0031640)	4.94808026
16	hematopoietic stem cell proliferation (GO:0071425)	4.92180925
17	sulfation (GO:0051923)	4.91553428
18	protein K63-linked deubiquitination (GO:0070536)	4.82353267
19	thyroid hormone metabolic process (GO:0042403)	4.62958412
20	lymphangiogenesis (GO:0001946)	4.33893766
21	protein K48-linked deubiquitination (GO:0071108)	4.29834743
22	mucosal immune response (GO:0002385)	4.28272106
23	tryptophan catabolic process (GO:0006569)	4.27227250
24	indole-containing compound catabolic process (GO:0042436)	4.27227250
25	indolalkylamine catabolic process (GO:0046218)	4.27227250
26	maturation of 5.8S rRNA (GO:0000460)	4.24685419
27	cysteine metabolic process (GO:0006534)	4.24568069
28	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	4.21026857
29	regulation of hair follicle development (GO:0051797)	4.20130663
30	rRNA catabolic process (GO:0016075)	4.14405790
31	omega-hydroxylase P450 pathway (GO:0097267)	4.04877316
32	organ or tissue specific immune response (GO:0002251)	3.95029882
33	translational termination (GO:0006415)	3.94683707
34	viral transcription (GO:0019083)	3.91586300
35	negative regulation of metanephros development (GO:0072217)	3.90746313
36	glycoprotein catabolic process (GO:0006516)	3.88169717
37	protein-cofactor linkage (GO:0018065)	3.87532515
38	carnitine transmembrane transport (GO:1902603)	3.77306023
39	homocysteine metabolic process (GO:0050667)	3.69938416
40	defense response to fungus (GO:0050832)	3.66867195
41	granulocyte differentiation (GO:0030851)	3.64172943
42	myoblast migration (GO:0051451)	3.58936953
43	organic cation transport (GO:0015695)	3.53675068
44	central nervous system myelination (GO:0022010)	3.52914535
45	axon ensheathment in central nervous system (GO:0032291)	3.52914535
46	positive regulation of cAMP-mediated signaling (GO:0043950)	3.50613347
47	flavonoid metabolic process (GO:0009812)	3.48857006
48	translational elongation (GO:0006414)	3.45801838
49	amino-acid betaine transport (GO:0015838)	3.42462470
50	carnitine transport (GO:0015879)	3.42462470
51	ribosomal small subunit assembly (GO:0000028)	3.40843473
52	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.38277878
53	startle response (GO:0001964)	3.36992358
54	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.35348488
55	spindle assembly involved in mitosis (GO:0090307)	3.34131212
56	negative regulation of mast cell activation (GO:0033004)	3.32529920
57	ribosomal small subunit biogenesis (GO:0042274)	3.31736424
58	replication fork processing (GO:0031297)	3.30193145
59	tryptophan metabolic process (GO:0006568)	3.26998489
60	neuron fate determination (GO:0048664)	3.22003513
61	carnitine metabolic process (GO:0009437)	3.19946225
62	protein sumoylation (GO:0016925)	3.19378269
63	sex differentiation (GO:0007548)	3.15739013
64	skeletal muscle tissue regeneration (GO:0043403)	3.08865286
65	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.08434854
66	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.08434854
67	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.08358706
68	protein K6-linked ubiquitination (GO:0085020)	3.08106514
69	lipid translocation (GO:0034204)	3.07496212
70	phospholipid translocation (GO:0045332)	3.07496212
71	negative regulation by host of viral transcription (GO:0043922)	3.07312159
72	viral life cycle (GO:0019058)	3.05396307
73	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.05252557
74	maturation of SSU-rRNA (GO:0030490)	3.04337392
75	protein targeting to ER (GO:0045047)	3.03602324
76	DNA double-strand break processing (GO:0000729)	3.02739046
77	cell killing (GO:0001906)	2.99600702
78	cotranslational protein targeting to membrane (GO:0006613)	2.98496083
79	filopodium assembly (GO:0046847)	2.97397822
80	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.92481740
81	protein complex biogenesis (GO:0070271)	2.91874223
82	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.91546928
83	pseudouridine synthesis (GO:0001522)	2.88742935
84	indolalkylamine metabolic process (GO:0006586)	2.88564859
85	thyroid hormone generation (GO:0006590)	2.88420068
86	negative regulation of telomere maintenance (GO:0032205)	2.86964825
87	regulation of B cell receptor signaling pathway (GO:0050855)	2.85836693
88	cellular protein complex disassembly (GO:0043624)	2.84283578
89	protein localization to endoplasmic reticulum (GO:0070972)	2.83926502
90	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.82226816
91	NADH dehydrogenase complex assembly (GO:0010257)	2.82226816
92	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.82226816
93	regulation of hair cycle (GO:0042634)	2.81974480
94	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.81912050
95	amino-acid betaine metabolic process (GO:0006577)	2.81251437
96	behavioral response to nicotine (GO:0035095)	2.79729273
97	parturition (GO:0007567)	2.79655686
98	amine catabolic process (GO:0009310)	2.76748916
99	cellular biogenic amine catabolic process (GO:0042402)	2.76748916
100	protein K11-linked deubiquitination (GO:0035871)	12.2597529

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.93939105
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.66156190
3	IKZF1_21737484_ChIP-ChIP_HCT116_Human	4.36356505
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.00848965
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.34313537
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.86230241
7	VDR_22108803_ChIP-Seq_LS180_Human	2.09031523
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.08607028
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.02034934
10	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.95688818
11	TP53_16413492_ChIP-PET_HCT116_Human	1.88280145
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.87228874
13	TP53_22573176_ChIP-Seq_HFKS_Human	1.85268205
14	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.82129230
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.75839222
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.74512781
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.74218253
18	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69855474
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69226841
20	EWS_26573619_Chip-Seq_HEK293_Human	1.68320326
21	AR_25329375_ChIP-Seq_VCAP_Human	1.65364105
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65253018
23	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.65116982
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.58755464
25	DROSHA_22980978_ChIP-Seq_HELA_Human	1.58463682
26	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.54793929
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.53547785
28	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.52731626
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48003192
30	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.47653702
31	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.40503281
32	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.38476710
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.37373659
34	FUS_26573619_Chip-Seq_HEK293_Human	1.33956550
35	ERA_21632823_ChIP-Seq_H3396_Human	1.33146636
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.31996897
37	IGF1R_20145208_ChIP-Seq_DFB_Human	1.31443902
38	P300_19829295_ChIP-Seq_ESCs_Human	1.31195742
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.31176460
40	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.30762928
41	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28779515
42	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.28765229
43	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.27744327
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26549250
45	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24489541
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21173649
47	CTCF_20526341_ChIP-Seq_ESCs_Human	1.20174118
48	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.19527390
49	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19447912
50	ERG_20517297_ChIP-Seq_VCAP_Human	1.16942792
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.16848933
52	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16398887
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.16124541
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16124541
55	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.16058668
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14139481
57	MYC_19829295_ChIP-Seq_ESCs_Human	1.13924597
58	STAT1_20625510_ChIP-Seq_HELA_Human	1.13867187
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13565994
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13565994
61	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12906848
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12702386
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.12063148
64	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.11469422
65	VDR_23849224_ChIP-Seq_CD4+_Human	1.10734633
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09467053
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09402777
68	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.09181993
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07906293
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07416393
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06940034
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06494233
73	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.06467002
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05681187
75	NCOR_22424771_ChIP-Seq_293T_Human	1.05084579
76	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.01771502
77	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.01445846
78	STAT3_23295773_ChIP-Seq_U87_Human	1.01078127
79	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.00902547
80	PHF8_20622853_ChIP-Seq_HELA_Human	1.00559332
81	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.00465187
82	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.00367567
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.98837957
84	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.98627677
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97967931
86	TTF2_22483619_ChIP-Seq_HELA_Human	0.97302970
87	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.96770812
88	FOXP3_21729870_ChIP-Seq_TREG_Human	0.96547413
89	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.96543909
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96449386
91	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.96256312
92	TCF4_22108803_ChIP-Seq_LS180_Human	0.95920727
93	TCF4_23295773_ChIP-Seq_U87_Human	0.94274216
94	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.93638870
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93223214
96	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92827981
97	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.92538475
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92013862
99	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.91863251
100	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.91855618

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	5.99870122
2	MP0008875_abnormal_xenobiotic_pharmacok	4.08457815
3	MP0003806_abnormal_nucleotide_metabolis	3.95777750
4	MP0002138_abnormal_hepatobiliary_system	3.81414385
5	MP0005670_abnormal_white_adipose	3.41539130
6	MP0005310_abnormal_salivary_gland	3.14340533
7	MP0001984_abnormal_olfaction	2.93124413
8	MP0002139_abnormal_hepatobiliary_system	2.68422183
9	MP0004043_abnormal_pH_regulation	2.31738462
10	MP0001919_abnormal_reproductive_system	2.30924958
11	MP0003646_muscle_fatigue	2.11707907
12	MP0005551_abnormal_eye_electrophysiolog	2.09354153
13	MP0009379_abnormal_foot_pigmentation	2.05825226
14	MP0002876_abnormal_thyroid_physiology	2.05491536
15	MP0005389_reproductive_system_phenotype	2.04613860
16	MP0004142_abnormal_muscle_tone	2.03471849
17	MP0005377_hearing/vestibular/ear_phenot	1.92335839
18	MP0003878_abnormal_ear_physiology	1.92335839
19	MP0006276_abnormal_autonomic_nervous	1.79901831
20	MP0006292_abnormal_olfactory_placode	1.75015169
21	MP0001905_abnormal_dopamine_level	1.72849204
22	MP0001873_stomach_inflammation	1.67443451
23	MP0009745_abnormal_behavioral_response	1.66434124
24	MP0009046_muscle_twitch	1.64615410
25	MP0002254_reproductive_system_inflammat	1.57405907
26	MP0004858_abnormal_nervous_system	1.56308487
27	MP0002163_abnormal_gland_morphology	1.51750744
28	MP0000613_abnormal_salivary_gland	1.51285602
29	MP0005084_abnormal_gallbladder_morpholo	1.49974230
30	MP0002064_seizures	1.41228616
31	MP0000230_abnormal_systemic_arterial	1.39407269
32	MP0002736_abnormal_nociception_after	1.37204106
33	MP0001879_abnormal_lymphatic_vessel	1.36956426
34	MP0001968_abnormal_touch/_nociception	1.35413806
35	MP0002277_abnormal_respiratory_mucosa	1.35351106
36	MP0002735_abnormal_chemical_nociception	1.35083345
37	MP0000569_abnormal_digit_pigmentation	1.34822543
38	MP0002006_tumorigenesis	1.31006305
39	MP0003724_increased_susceptibility_to	1.30087501
40	MP0001986_abnormal_taste_sensitivity	1.28546122
41	MP0002272_abnormal_nervous_system	1.22068848
42	MP0003638_abnormal_response/metabolism_	1.21913552
43	MP0002638_abnormal_pupillary_reflex	1.19840631
44	MP0000427_abnormal_hair_cycle	1.19179728
45	MP0008877_abnormal_DNA_methylation	1.17441794
46	MP0000631_abnormal_neuroendocrine_gland	1.15539787
47	MP0001970_abnormal_pain_threshold	1.15406740
48	MP0004145_abnormal_muscle_electrophysio	1.13114994
49	MP0002160_abnormal_reproductive_system	1.12789821
50	MP0005360_urolithiasis	1.11107190
51	MP0001486_abnormal_startle_reflex	1.09509965
52	MP0000372_irregular_coat_pigmentation	1.07298971
53	MP0002572_abnormal_emotion/affect_behav	1.07260473
54	MP0005647_abnormal_sex_gland	1.05530232
55	MP0006082_CNS_inflammation	1.02566126
56	MP0006072_abnormal_retinal_apoptosis	1.01563841
57	MP0002234_abnormal_pharynx_morphology	1.01341596
58	MP0002928_abnormal_bile_duct	0.98929908
59	MP0001348_abnormal_lacrimal_gland	0.98806525
60	MP0003936_abnormal_reproductive_system	0.97829080
61	MP0001440_abnormal_grooming_behavior	0.97715564
62	MP0001764_abnormal_homeostasis	0.95544970
63	MP0002970_abnormal_white_adipose	0.95052665
64	MP0000685_abnormal_immune_system	0.93668373
65	MP0005253_abnormal_eye_physiology	0.91799013
66	MP0008872_abnormal_physiological_respon	0.90344020
67	MP0003787_abnormal_imprinting	0.89173760
68	MP0005195_abnormal_posterior_eye	0.88958577
69	MP0002734_abnormal_mechanical_nocicepti	0.88570561
70	MP0002653_abnormal_ependyma_morphology	0.87841128
71	MP0003315_abnormal_perineum_morphology	0.87785359
72	MP0005645_abnormal_hypothalamus_physiol	0.85234914
73	MP0009764_decreased_sensitivity_to	0.84627263
74	MP0003195_calcinosis	0.82916438
75	MP0002837_dystrophic_cardiac_calcinosis	0.82034918
76	MP0005174_abnormal_tail_pigmentation	0.81547666
77	MP0000639_abnormal_adrenal_gland	0.80021614
78	MP0002938_white_spotting	0.79692933
79	MP0002095_abnormal_skin_pigmentation	0.79593830
80	MP0005387_immune_system_phenotype	0.78901951
81	MP0001790_abnormal_immune_system	0.78901951
82	MP0005187_abnormal_penis_morphology	0.76110146
83	MP0002063_abnormal_learning/memory/cond	0.75970820
84	MP0004019_abnormal_vitamin_homeostasis	0.75569499
85	MP0005379_endocrine/exocrine_gland_phen	0.75010099
86	MP0001485_abnormal_pinna_reflex	0.74934910
87	MP0001663_abnormal_digestive_system	0.74737165
88	MP0008789_abnormal_olfactory_epithelium	0.73668198
89	MP0002210_abnormal_sex_determination	0.72792093
90	MP0005332_abnormal_amino_acid	0.71555960
91	MP0001835_abnormal_antigen_presentation	0.66280644
92	MP0002148_abnormal_hypersensitivity_rea	0.64287792
93	MP0003136_yellow_coat_color	0.62453493
94	MP0005448_abnormal_energy_balance	0.61600245
95	MP0006036_abnormal_mitochondrial_physio	0.60200934
96	MP0003718_maternal_effect	0.60112163
97	MP0002229_neurodegeneration	0.59998300
98	MP0002067_abnormal_sensory_capabilities	0.59772459
99	MP0010329_abnormal_lipoprotein_level	0.59377611
100	MP0001501_abnormal_sleep_pattern	0.56691296

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital sensorineural hearing impairment (HP:0008527)	4.48816004
2	Retrobulbar optic neuritis (HP:0100654)	4.23575681
3	Optic neuritis (HP:0100653)	4.23575681
4	Congenital stationary night blindness (HP:0007642)	4.18252028
5	Decreased circulating renin level (HP:0003351)	3.88737168
6	True hermaphroditism (HP:0010459)	3.76843027
7	Abolished electroretinogram (ERG) (HP:0000550)	3.75166845
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.69533910
9	Orchitis (HP:0100796)	3.69367266
10	Pancreatic cysts (HP:0001737)	3.60171756
11	Poikiloderma (HP:0001029)	3.57289236
12	Bilateral sensorineural hearing impairment (HP:0008619)	3.43572550
13	Keratoconjunctivitis (HP:0001096)	3.35740967
14	Hypoplasia of the uterus (HP:0000013)	3.34251268
15	Pancreatic fibrosis (HP:0100732)	3.30331006
16	Molar tooth sign on MRI (HP:0002419)	3.17860858
17	Abnormality of midbrain morphology (HP:0002418)	3.17860858
18	Acute encephalopathy (HP:0006846)	3.17644407
19	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.17396981
20	Abnormal number of erythroid precursors (HP:0012131)	3.15205132
21	Acute necrotizing encephalopathy (HP:0006965)	3.12605909
22	Myositis (HP:0100614)	3.08010730
23	Attenuation of retinal blood vessels (HP:0007843)	3.02402038
24	Stomatitis (HP:0010280)	2.99099532
25	Abnormal pancreas size (HP:0012094)	2.98719482
26	Lower limb hyperreflexia (HP:0002395)	2.85708100
27	Reticulocytopenia (HP:0001896)	2.82042786
28	Bony spicule pigmentary retinopathy (HP:0007737)	2.80071109
29	Male pseudohermaphroditism (HP:0000037)	2.74454016
30	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.74324667
31	Mitochondrial inheritance (HP:0001427)	2.73348226
32	Hepatocellular necrosis (HP:0001404)	2.73146902
33	Aplasia/hypoplasia of the uterus (HP:0008684)	2.72531356
34	Constricted visual fields (HP:0001133)	2.71400552
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.71078495
36	Enlarged penis (HP:0000040)	2.69875817
37	Hyperglycinemia (HP:0002154)	2.62160492
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.62005366
39	Abnormal mitochondria in muscle tissue (HP:0008316)	2.58271199
40	Abnormality of the pericardium (HP:0001697)	2.53379000
41	Keratoconjunctivitis sicca (HP:0001097)	2.50387270
42	Polydipsia (HP:0001959)	2.49475131
43	Abnormal drinking behavior (HP:0030082)	2.49475131
44	3-Methylglutaconic aciduria (HP:0003535)	2.46757533
45	Hyperglycinuria (HP:0003108)	2.46012136
46	Progressive macrocephaly (HP:0004481)	2.44168926
47	Macrocytic anemia (HP:0001972)	2.43225730
48	Gout (HP:0001997)	2.39165088
49	Hepatic necrosis (HP:0002605)	2.38918335
50	Tinnitus (HP:0000360)	2.38250721
51	Increased CSF lactate (HP:0002490)	2.34705891
52	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.32938586
53	Bile duct proliferation (HP:0001408)	2.32455231
54	Abnormal biliary tract physiology (HP:0012439)	2.32455231
55	Nephronophthisis (HP:0000090)	2.30634198
56	Absent thumb (HP:0009777)	2.23195502
57	Congenital, generalized hypertrichosis (HP:0004540)	2.18705670
58	Asplenia (HP:0001746)	2.16669250
59	Cystic liver disease (HP:0006706)	2.16174822
60	Anomalous pulmonary venous return (HP:0010772)	2.16143151
61	Hyperventilation (HP:0002883)	2.12493099
62	Hyperaldosteronism (HP:0000859)	2.11192212
63	Chronic hepatic failure (HP:0100626)	2.10667492
64	Anorexia (HP:0002039)	2.05751013
65	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.05413729
66	Elevated erythrocyte sedimentation rate (HP:0003565)	2.03699958
67	Absent/shortened dynein arms (HP:0200106)	2.02656688
68	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.02656688
69	Abnormality of glycine metabolism (HP:0010895)	2.00757678
70	Abnormality of serine family amino acid metabolism (HP:0010894)	2.00757678
71	Abnormality of renin-angiotensin system (HP:0000847)	1.99730883
72	CNS demyelination (HP:0007305)	1.98954890
73	Chronic bronchitis (HP:0004469)	1.97823454
74	Cerebral edema (HP:0002181)	1.96387575
75	Gonadotropin excess (HP:0000837)	1.96301844
76	Polyuria (HP:0000103)	1.95551920
77	Abnormality of dentin (HP:0010299)	1.92562224
78	Abnormality of the renal medulla (HP:0100957)	1.89081316
79	Abnormal ciliary motility (HP:0012262)	1.86556486
80	Retinal atrophy (HP:0001105)	1.84984014
81	Abnormality of the pulmonary veins (HP:0011718)	1.81971627
82	Xanthomatosis (HP:0000991)	1.81816914
83	Anencephaly (HP:0002323)	1.80893662
84	Abnormality of the renal cortex (HP:0011035)	1.80097945
85	Spastic tetraparesis (HP:0001285)	1.78969462
86	Optic disc pallor (HP:0000543)	1.77660970
87	Hypokalemic alkalosis (HP:0001949)	1.76730642
88	Abnormality of dental color (HP:0011073)	1.75945021
89	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.74944355
90	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.74435037
91	Abnormal respiratory motile cilium physiology (HP:0012261)	1.72587437
92	Abnormal eating behavior (HP:0100738)	1.72040984
93	Hemoptysis (HP:0002105)	1.72026313
94	Oligomenorrhea (HP:0000876)	1.71941266
95	Medial flaring of the eyebrow (HP:0010747)	1.70784417
96	Sclerocornea (HP:0000647)	1.69649151
97	Pallor (HP:0000980)	1.69456996
98	Encephalitis (HP:0002383)	1.69108670
99	Retinitis pigmentosa (HP:0000510)	1.69092942
100	Hypokalemia (HP:0002900)	1.68950063

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.30777313
2	WNK3	6.45545153
3	TXK	5.36920186
4	PINK1	4.16423282
5	WNK4	2.35992227
6	BLK	2.26221796
7	ZAK	2.26099959
8	ADRBK2	2.18678026
9	MAPKAPK3	2.07305047
10	GRK1	1.85219621
11	BMPR1B	1.68530778
12	STK16	1.67890350
13	STK39	1.64750714
14	NME1	1.53564858
15	PIK3CA	1.49822631
16	OXSR1	1.36250245
17	TAOK3	1.31274541
18	NEK1	1.28081191
19	LIMK1	1.23530895
20	CDK19	1.22733820
21	NTRK3	1.17364385
22	TIE1	1.15432500
23	PRKCZ	1.14008723
24	TLK1	1.07914423
25	EIF2AK3	1.04774413
26	PRKD3	1.03519126
27	DYRK2	1.00656331
28	MAPKAPK5	0.99327608
29	BCKDK	0.93831576
30	YES1	0.91084253
31	MAPK13	0.90952422
32	CSK	0.90044431
33	EIF2AK2	0.89477505
34	GRK7	0.81601284
35	ADRBK1	0.81420769
36	EEF2K	0.81040274
37	IRAK1	0.79566900
38	MAP4K2	0.76988400
39	CAMK1	0.76099013
40	FER	0.75763711
41	TEC	0.75740209
42	TRPM7	0.73516023
43	PRKG1	0.73044006
44	CHEK2	0.68998793
45	TYRO3	0.65244022
46	PRKCG	0.65202455
47	MUSK	0.62721460
48	IKBKB	0.62067657
49	PHKG1	0.61838230
50	PHKG2	0.61838230
51	RPS6KB2	0.61291243
52	PASK	0.61080193
53	OBSCN	0.59251004
54	IGF1R	0.58462969
55	DAPK1	0.57615243
56	MAP3K12	0.56636197
57	PRKCA	0.54686315
58	RPS6KA5	0.54099639
59	NME2	0.53135416
60	CAMK1D	0.52903177
61	PRKACA	0.51503694
62	INSRR	0.51410642
63	RPS6KA6	0.49424126
64	NUAK1	0.46556384
65	MARK3	0.45056557
66	GRK5	0.44610616
67	CSF1R	0.44348608
68	NEK2	0.42836965
69	RPS6KA2	0.42509369
70	MYLK	0.39639076
71	WNK1	0.39562262
72	PRKCB	0.39541282
73	DAPK3	0.38699991
74	LYN	0.38521873
75	PRKCQ	0.37767950
76	CAMK2A	0.36759086
77	STK38L	0.33641657
78	PRKCH	0.31861730
79	RPS6KL1	0.31068726
80	RPS6KC1	0.31068726
81	PRKCE	0.30237599
82	CSNK1A1	0.30078839
83	CAMKK2	0.29188013
84	CSNK2A2	0.28374315
85	PLK4	0.27934254
86	PRKD2	0.27822385
87	BTK	0.27460291
88	MAP3K7	0.27318337
89	TRIM28	0.26587940
90	KIT	0.26585972
91	AURKA	0.26415756
92	VRK2	0.25672800
93	ITK	0.24840486
94	PLK1	0.24832277
95	RPS6KA3	0.24296687
96	CSNK2A1	0.23929097
97	MAP4K1	0.23657185
98	ABL2	0.22920816
99	CAMK2D	0.21743634
100	PLK2	0.21641372

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.99303148
2	Glycosaminoglycan degradation_Homo sapiens_hsa00531	3.37684656
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.03761863
4	Proteasome_Homo sapiens_hsa03050	2.72407306
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.61177791
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.50897594
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.47451300
8	Parkinsons disease_Homo sapiens_hsa05012	2.33910484
9	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.11238573
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.06823304
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.90086044
12	Asthma_Homo sapiens_hsa05310	1.87004810
13	Huntingtons disease_Homo sapiens_hsa05016	1.80360286
14	Butanoate metabolism_Homo sapiens_hsa00650	1.79632261
15	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.76563182
16	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.76422050
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.70692629
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.68804347
19	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.67129107
20	Nicotine addiction_Homo sapiens_hsa05033	1.65609381
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.63538800
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.60194748
23	Alzheimers disease_Homo sapiens_hsa05010	1.57418786
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.56887626
25	Phototransduction_Homo sapiens_hsa04744	1.53176192
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.48592781
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.41709382
28	Propanoate metabolism_Homo sapiens_hsa00640	1.41688715
29	Fat digestion and absorption_Homo sapiens_hsa04975	1.40104566
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.32122656
31	Homologous recombination_Homo sapiens_hsa03440	1.25468485
32	RNA degradation_Homo sapiens_hsa03018	1.21386926
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20987929
34	Serotonergic synapse_Homo sapiens_hsa04726	1.19350183
35	Allograft rejection_Homo sapiens_hsa05330	1.19129597
36	Olfactory transduction_Homo sapiens_hsa04740	1.18017324
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.16974580
38	Glutathione metabolism_Homo sapiens_hsa00480	1.14531251
39	Histidine metabolism_Homo sapiens_hsa00340	1.13449120
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12629631
41	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.10133848
42	Salivary secretion_Homo sapiens_hsa04970	1.08058799
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06787709
44	Peroxisome_Homo sapiens_hsa04146	1.04626296
45	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.03761918
46	Protein export_Homo sapiens_hsa03060	1.00042537
47	Glycerolipid metabolism_Homo sapiens_hsa00561	0.99910472
48	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.97160340
49	RNA polymerase_Homo sapiens_hsa03020	0.96263418
50	One carbon pool by folate_Homo sapiens_hsa00670	0.95516467
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95292653
52	Calcium signaling pathway_Homo sapiens_hsa04020	0.94054617
53	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.92843088
54	Morphine addiction_Homo sapiens_hsa05032	0.88368781
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.88251865
56	Graft-versus-host disease_Homo sapiens_hsa05332	0.88120975
57	Type I diabetes mellitus_Homo sapiens_hsa04940	0.86330376
58	DNA replication_Homo sapiens_hsa03030	0.85576691
59	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85012403
60	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80998460
61	Primary immunodeficiency_Homo sapiens_hsa05340	0.80421405
62	RNA transport_Homo sapiens_hsa03013	0.79967480
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79432994
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.77201966
65	Basal transcription factors_Homo sapiens_hsa03022	0.75585851
66	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.72741795
67	Metabolic pathways_Homo sapiens_hsa01100	0.71298278
68	Sulfur relay system_Homo sapiens_hsa04122	0.70965562
69	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.70158719
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67230673
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66760425
72	Nitrogen metabolism_Homo sapiens_hsa00910	0.64811364
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63910189
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63651700
75	Caffeine metabolism_Homo sapiens_hsa00232	0.63433195
76	Retinol metabolism_Homo sapiens_hsa00830	0.63393679
77	Fatty acid degradation_Homo sapiens_hsa00071	0.61633528
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61082418
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60350086
80	Base excision repair_Homo sapiens_hsa03410	0.59995773
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59300784
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.57433824
83	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.51725597
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.51406385
85	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.50389995
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49234480
87	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47860730
88	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.47620908
89	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.46807624
90	Mineral absorption_Homo sapiens_hsa04978	0.45992153
91	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.44308207
92	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.44185084
93	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.43063858
94	GABAergic synapse_Homo sapiens_hsa04727	0.37548134
95	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.37080287
96	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.37075040
97	Cholinergic synapse_Homo sapiens_hsa04725	0.37038020
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36769035
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35198797
100	Pyruvate metabolism_Homo sapiens_hsa00620	0.34620433

RPL21P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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