ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.04492261
2	translational termination (GO:0006415)	5.80217937
3	ATP synthesis coupled proton transport (GO:0015986)	5.64042246
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.64042246
5	ribosomal small subunit assembly (GO:0000028)	5.46036143
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.35314925
7	cotranslational protein targeting to membrane (GO:0006613)	5.28418382
8	protein targeting to ER (GO:0045047)	5.24591167
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.13795093
10	chaperone-mediated protein transport (GO:0072321)	5.10289425
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.04985024
12	translational elongation (GO:0006414)	4.99741444
13	protein localization to endoplasmic reticulum (GO:0070972)	4.97499658
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.96276132
15	ribosomal large subunit biogenesis (GO:0042273)	4.93091847
16	ribosomal small subunit biogenesis (GO:0042274)	4.82244800
17	DNA deamination (GO:0045006)	4.68087778
18	maturation of SSU-rRNA (GO:0030490)	4.65261947
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.52493926
20	protein neddylation (GO:0045116)	4.32917156
21	viral life cycle (GO:0019058)	4.27972897
22	cellular protein complex disassembly (GO:0043624)	4.25676770
23	protein complex biogenesis (GO:0070271)	4.10745852
24	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.10697230
25	translational initiation (GO:0006413)	4.04896843
26	electron transport chain (GO:0022900)	4.01166792
27	respiratory electron transport chain (GO:0022904)	4.00158978
28	NADH dehydrogenase complex assembly (GO:0010257)	3.96101768
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.96101768
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.96101768
31	behavioral response to nicotine (GO:0035095)	3.80988402
32	translation (GO:0006412)	3.79635753
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.77707128
34	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.74859550
35	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.72824671
36	water-soluble vitamin biosynthetic process (GO:0042364)	3.70826032
37	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.50372366
38	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.50372366
39	protein complex disassembly (GO:0043241)	3.44298966
40	GTP biosynthetic process (GO:0006183)	3.41827842
41	protein targeting to membrane (GO:0006612)	3.40424456
42	respiratory chain complex IV assembly (GO:0008535)	3.37442921
43	macromolecular complex disassembly (GO:0032984)	3.33142032
44	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.31687336
45	termination of RNA polymerase III transcription (GO:0006386)	3.27957843
46	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.27957843
47	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.26374278
48	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.23875567
49	ATP biosynthetic process (GO:0006754)	3.21494205
50	cellular component biogenesis (GO:0044085)	3.20634434
51	kynurenine metabolic process (GO:0070189)	3.16120163
52	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.15458947
53	hydrogen ion transmembrane transport (GO:1902600)	3.10678952
54	ribonucleoprotein complex biogenesis (GO:0022613)	3.09727916
55	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.07475931
56	mRNA catabolic process (GO:0006402)	3.06190170
57	cytochrome complex assembly (GO:0017004)	2.99985404
58	indole-containing compound catabolic process (GO:0042436)	2.95485121
59	indolalkylamine catabolic process (GO:0046218)	2.95485121
60	tryptophan catabolic process (GO:0006569)	2.95485121
61	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.94545361
62	protein-cofactor linkage (GO:0018065)	2.91125731
63	proton transport (GO:0015992)	2.90968593
64	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90464515
65	rRNA metabolic process (GO:0016072)	2.86224319
66	rRNA processing (GO:0006364)	2.85255111
67	hydrogen transport (GO:0006818)	2.84980299
68	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.81353797
69	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.79937649
70	RNA catabolic process (GO:0006401)	2.79500882
71	nonmotile primary cilium assembly (GO:0035058)	2.78455585
72	indolalkylamine metabolic process (GO:0006586)	2.78074157
73	UTP biosynthetic process (GO:0006228)	2.75855504
74	platelet dense granule organization (GO:0060155)	2.75729677
75	proteasome assembly (GO:0043248)	2.74727626
76	inner mitochondrial membrane organization (GO:0007007)	2.72825772
77	GPI anchor metabolic process (GO:0006505)	2.72447365
78	intracellular protein transmembrane import (GO:0044743)	2.72435726
79	organelle disassembly (GO:1903008)	2.71150397
80	piRNA metabolic process (GO:0034587)	2.70818579
81	positive regulation of defense response to virus by host (GO:0002230)	2.68575452
82	positive regulation of protein homodimerization activity (GO:0090073)	2.68382083
83	GPI anchor biosynthetic process (GO:0006506)	2.67494291
84	UTP metabolic process (GO:0046051)	2.64445259
85	tRNA processing (GO:0008033)	2.61715502
86	peptidyl-histidine modification (GO:0018202)	2.61486428
87	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.60613101
88	regulation of immunoglobulin secretion (GO:0051023)	2.58165208
89	base-excision repair, AP site formation (GO:0006285)	2.56309284
90	rRNA catabolic process (GO:0016075)	2.56199145
91	aldehyde catabolic process (GO:0046185)	2.56198961
92	regulation of isotype switching to IgG isotypes (GO:0048302)	2.54345114
93	protein targeting to mitochondrion (GO:0006626)	2.51955084
94	somite development (GO:0061053)	2.49491653
95	rRNA modification (GO:0000154)	2.45606712
96	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.45389365
97	establishment of protein localization to mitochondrion (GO:0072655)	2.44954020
98	cornea development in camera-type eye (GO:0061303)	2.44542446
99	mannosylation (GO:0097502)	2.44184161
100	L-fucose metabolic process (GO:0042354)	2.44144546

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.13783097
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.98491145
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.57074236
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.40704828
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.05841950
6	VDR_22108803_ChIP-Seq_LS180_Human	2.96254832
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.81038130
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.47642260
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.41944326
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.38863674
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.32724611
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.30630361
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.24849912
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.11280274
15	FOXP3_21729870_ChIP-Seq_TREG_Human	2.07319351
16	EZH2_22144423_ChIP-Seq_EOC_Human	1.99143180
17	MYC_18940864_ChIP-ChIP_HL60_Human	1.89359724
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.87990150
19	EWS_26573619_Chip-Seq_HEK293_Human	1.84912380
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.82195269
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.78920315
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74869563
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72323275
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.64272392
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.62338836
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62294991
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60732160
28	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.56565025
29	IGF1R_20145208_ChIP-Seq_DFB_Human	1.49722021
30	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.49286423
31	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.49286423
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.48453440
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.47915651
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46855785
35	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46408061
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45901338
37	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45492336
38	FUS_26573619_Chip-Seq_HEK293_Human	1.40143044
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.40099834
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.38705012
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.38171044
42	P300_19829295_ChIP-Seq_ESCs_Human	1.37386346
43	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.35714208
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33912786
45	AR_20517297_ChIP-Seq_VCAP_Human	1.33717326
46	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.31745562
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29691602
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.29271642
49	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.27546288
50	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.26040056
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25065732
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24924492
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24924492
54	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.24604027
55	GATA3_26560356_Chip-Seq_TH2_Human	1.23559150
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21886618
57	GBX2_23144817_ChIP-Seq_PC3_Human	1.21711467
58	TAF15_26573619_Chip-Seq_HEK293_Human	1.20503478
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.19011272
60	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.18864493
61	NCOR_22424771_ChIP-Seq_293T_Human	1.17068918
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15509768
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13428059
64	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12598022
65	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.10443429
66	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.09118482
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08846621
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08766396
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08748267
70	CBP_20019798_ChIP-Seq_JUKART_Human	1.07919006
71	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07919006
72	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.07624424
73	MYC_19829295_ChIP-Seq_ESCs_Human	1.06282908
74	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05834744
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05805607
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03652902
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03339973
78	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.03082005
79	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01645650
80	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.01518911
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.00324769
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00227071
83	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.00221458
84	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.99774553
85	TCF4_22108803_ChIP-Seq_LS180_Human	0.99680576
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.97410108
87	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.96876251
88	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95034063
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93250744
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.92442962
91	GABP_19822575_ChIP-Seq_HepG2_Human	0.91866041
92	ERA_21632823_ChIP-Seq_H3396_Human	0.90964493
93	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.90912642
94	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.90686731
95	ERG_20517297_ChIP-Seq_VCAP_Human	0.90133071
96	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.88719318
97	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.86091398
98	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85377753
99	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.85260431
100	RNF2_27304074_Chip-Seq_NSC_Mouse	0.84819100

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.64832409
2	MP0009379_abnormal_foot_pigmentation	3.99699639
3	MP0008877_abnormal_DNA_methylation	3.68080605
4	MP0003787_abnormal_imprinting	2.95589649
5	MP0001835_abnormal_antigen_presentation	2.79710158
6	MP0005671_abnormal_response_to	2.56301611
7	MP0006072_abnormal_retinal_apoptosis	2.40680350
8	MP0002102_abnormal_ear_morphology	2.30075197
9	MP0002638_abnormal_pupillary_reflex	2.11444529
10	MP0008789_abnormal_olfactory_epithelium	2.06565736
11	MP0008875_abnormal_xenobiotic_pharmacok	1.96725803
12	MP0002837_dystrophic_cardiac_calcinosis	1.95621374
13	MP0005084_abnormal_gallbladder_morpholo	1.87725116
14	MP0001968_abnormal_touch/_nociception	1.86762529
15	MP0008872_abnormal_physiological_respon	1.84027387
16	MP0004142_abnormal_muscle_tone	1.83058693
17	MP0003806_abnormal_nucleotide_metabolis	1.82275013
18	MP0001986_abnormal_taste_sensitivity	1.82079832
19	MP0003646_muscle_fatigue	1.81823477
20	MP0005551_abnormal_eye_electrophysiolog	1.75605028
21	MP0003011_delayed_dark_adaptation	1.73523506
22	MP0004147_increased_porphyrin_level	1.68368069
23	MP0002938_white_spotting	1.67189295
24	MP0002736_abnormal_nociception_after	1.66384143
25	MP0004885_abnormal_endolymph	1.65329489
26	MP0002876_abnormal_thyroid_physiology	1.64479793
27	MP0002163_abnormal_gland_morphology	1.62282329
28	MP0003195_calcinosis	1.61627331
29	MP0004145_abnormal_muscle_electrophysio	1.50494664
30	MP0005499_abnormal_olfactory_system	1.38538909
31	MP0005394_taste/olfaction_phenotype	1.38538909
32	MP0003878_abnormal_ear_physiology	1.38437045
33	MP0005377_hearing/vestibular/ear_phenot	1.38437045
34	MP0005389_reproductive_system_phenotype	1.37762841
35	MP0002160_abnormal_reproductive_system	1.33688508
36	MP0005253_abnormal_eye_physiology	1.33429600
37	MP0002138_abnormal_hepatobiliary_system	1.32562253
38	MP0002272_abnormal_nervous_system	1.29618146
39	MP0001800_abnormal_humoral_immune	1.27082407
40	MP0005646_abnormal_pituitary_gland	1.25896407
41	MP0001293_anophthalmia	1.23997315
42	MP0005645_abnormal_hypothalamus_physiol	1.23450734
43	MP0001905_abnormal_dopamine_level	1.22792341
44	MP0001919_abnormal_reproductive_system	1.18168702
45	MP0005075_abnormal_melanosome_morpholog	1.18038086
46	MP0002277_abnormal_respiratory_mucosa	1.17935851
47	MP0005379_endocrine/exocrine_gland_phen	1.17647939
48	MP0003786_premature_aging	1.16824553
49	MP0006276_abnormal_autonomic_nervous	1.16681716
50	MP0000685_abnormal_immune_system	1.15480566
51	MP0006036_abnormal_mitochondrial_physio	1.14790669
52	MP0009785_altered_susceptibility_to	1.14407058
53	MP0002148_abnormal_hypersensitivity_rea	1.13626690
54	MP0003122_maternal_imprinting	1.13625813
55	MP0001873_stomach_inflammation	1.12673679
56	MP0002653_abnormal_ependyma_morphology	1.11927933
57	MP0001501_abnormal_sleep_pattern	1.10284643
58	MP0009745_abnormal_behavioral_response	1.09733199
59	MP0003283_abnormal_digestive_organ	1.09064331
60	MP0009046_muscle_twitch	1.06676961
61	MP0000631_abnormal_neuroendocrine_gland	1.05631901
62	MP0009764_decreased_sensitivity_to	1.05572133
63	MP0003186_abnormal_redox_activity	1.04163707
64	MP0005387_immune_system_phenotype	1.03400918
65	MP0001790_abnormal_immune_system	1.03400918
66	MP0003121_genomic_imprinting	1.02127572
67	MP0005000_abnormal_immune_tolerance	1.00480977
68	MP0001348_abnormal_lacrimal_gland	0.99413173
69	MP0000427_abnormal_hair_cycle	0.98589180
70	MP0001486_abnormal_startle_reflex	0.96713019
71	MP0001984_abnormal_olfaction	0.96117628
72	MP0001485_abnormal_pinna_reflex	0.96112209
73	MP0003880_abnormal_central_pattern	0.95163847
74	MP0009333_abnormal_splenocyte_physiolog	0.92656083
75	MP0002723_abnormal_immune_serum	0.92147372
76	MP0000372_irregular_coat_pigmentation	0.89944784
77	MP0001970_abnormal_pain_threshold	0.89357183
78	MP0005636_abnormal_mineral_homeostasis	0.89091736
79	MP0002166_altered_tumor_susceptibility	0.88135495
80	MP0004742_abnormal_vestibular_system	0.87906841
81	MP0001502_abnormal_circadian_rhythm	0.87002753
82	MP0002095_abnormal_skin_pigmentation	0.86958855
83	MP0002006_tumorigenesis	0.86922435
84	MP0001440_abnormal_grooming_behavior	0.86499969
85	MP0005195_abnormal_posterior_eye	0.84294573
86	MP0008058_abnormal_DNA_repair	0.80688262
87	MP0004133_heterotaxia	0.79766231
88	MP0005174_abnormal_tail_pigmentation	0.78984161
89	MP0002452_abnormal_antigen_presenting	0.78860788
90	MP0008995_early_reproductive_senescence	0.77071414
91	MP0003763_abnormal_thymus_physiology	0.75478980
92	MP0001819_abnormal_immune_cell	0.75008929
93	MP0002693_abnormal_pancreas_physiology	0.74999458
94	MP0005332_abnormal_amino_acid	0.73792280
95	MP0002735_abnormal_chemical_nociception	0.72521014
96	MP0002572_abnormal_emotion/affect_behav	0.72379673
97	MP0000613_abnormal_salivary_gland	0.72326931
98	MP0002420_abnormal_adaptive_immunity	0.72323520
99	MP0001765_abnormal_ion_homeostasis	0.72016905
100	MP0001529_abnormal_vocalization	0.71846597

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.68203816
2	Mitochondrial inheritance (HP:0001427)	4.09916912
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.05497786
4	Acute encephalopathy (HP:0006846)	4.04116382
5	Progressive macrocephaly (HP:0004481)	3.98788462
6	Molar tooth sign on MRI (HP:0002419)	3.76490087
7	Abnormality of midbrain morphology (HP:0002418)	3.76490087
8	Increased CSF lactate (HP:0002490)	3.70939675
9	Reticulocytopenia (HP:0001896)	3.60753482
10	Lipid accumulation in hepatocytes (HP:0006561)	3.57655917
11	3-Methylglutaconic aciduria (HP:0003535)	3.56214483
12	Hepatocellular necrosis (HP:0001404)	3.52287796
13	Abnormality of cells of the erythroid lineage (HP:0012130)	3.47815031
14	Increased hepatocellular lipid droplets (HP:0006565)	3.38411960
15	Pancreatic cysts (HP:0001737)	3.20412726
16	Congenital stationary night blindness (HP:0007642)	3.11400923
17	Macrocytic anemia (HP:0001972)	3.11246818
18	Congenital, generalized hypertrichosis (HP:0004540)	3.10239448
19	Hepatic necrosis (HP:0002605)	3.08561379
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.98278060
21	Pancreatic fibrosis (HP:0100732)	2.94977052
22	Cerebral edema (HP:0002181)	2.93587741
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.88755657
24	Nephronophthisis (HP:0000090)	2.83314136
25	Type II lissencephaly (HP:0007260)	2.79207716
26	Abnormal number of erythroid precursors (HP:0012131)	2.78195806
27	Optic disc pallor (HP:0000543)	2.73307655
28	IgG deficiency (HP:0004315)	2.70195379
29	Methylmalonic acidemia (HP:0002912)	2.63201740
30	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.62264884
31	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.62264884
32	Abnormality of the renal cortex (HP:0011035)	2.54511653
33	Increased intramyocellular lipid droplets (HP:0012240)	2.52354373
34	True hermaphroditism (HP:0010459)	2.49978403
35	Increased serum lactate (HP:0002151)	2.48409792
36	Renal Fanconi syndrome (HP:0001994)	2.46327300
37	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.45378199
38	Abnormality of the renal medulla (HP:0100957)	2.41712029
39	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.41572403
40	Hypoplasia of the fovea (HP:0007750)	2.41572403
41	Exertional dyspnea (HP:0002875)	2.39160672
42	Increased muscle lipid content (HP:0009058)	2.38085453
43	Lactic acidosis (HP:0003128)	2.37807788
44	Stomatitis (HP:0010280)	2.35490597
45	Methylmalonic aciduria (HP:0012120)	2.35231817
46	Medial flaring of the eyebrow (HP:0010747)	2.34101147
47	Pallor (HP:0000980)	2.33476322
48	Respiratory failure (HP:0002878)	2.25561798
49	Leukodystrophy (HP:0002415)	2.20413293
50	Abolished electroretinogram (ERG) (HP:0000550)	2.19693702
51	Colon cancer (HP:0003003)	2.19326574
52	Hypomagnesemia (HP:0002917)	2.17355830
53	Pendular nystagmus (HP:0012043)	2.16924786
54	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.15550553
55	Lethargy (HP:0001254)	2.13519411
56	Septo-optic dysplasia (HP:0100842)	2.12376961
57	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.10108138
58	Abnormal drinking behavior (HP:0030082)	2.09473345
59	Polydipsia (HP:0001959)	2.09473345
60	Stenosis of the external auditory canal (HP:0000402)	2.08952358
61	Asplenia (HP:0001746)	2.07135672
62	Hyperglycinemia (HP:0002154)	2.06870213
63	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.02807961
64	Elevated erythrocyte sedimentation rate (HP:0003565)	2.00570065
65	Constricted visual fields (HP:0001133)	1.97222577
66	Sclerocornea (HP:0000647)	1.96978961
67	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.94789940
68	Absent/shortened dynein arms (HP:0200106)	1.94789940
69	Absent thumb (HP:0009777)	1.91622975
70	Renal cortical cysts (HP:0000803)	1.90309103
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.90305457
72	Optic nerve hypoplasia (HP:0000609)	1.89150937
73	Abnormality of the fovea (HP:0000493)	1.85925355
74	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.85853448
75	Hypoproteinemia (HP:0003075)	1.85490131
76	Exercise intolerance (HP:0003546)	1.85385747
77	Polyuria (HP:0000103)	1.85372159
78	Glycosuria (HP:0003076)	1.84927615
79	Abnormality of urine glucose concentration (HP:0011016)	1.84927615
80	Abnormal respiratory epithelium morphology (HP:0012253)	1.84499150
81	Abnormal respiratory motile cilium morphology (HP:0005938)	1.84499150
82	Abnormality of renal resorption (HP:0011038)	1.84464031
83	Cystic liver disease (HP:0006706)	1.83016114
84	Abnormality of magnesium homeostasis (HP:0004921)	1.81698590
85	Abnormality of the pons (HP:0007361)	1.78977085
86	Increased corneal curvature (HP:0100692)	1.77658726
87	Keratoconus (HP:0000563)	1.77658726
88	Decreased central vision (HP:0007663)	1.76415366
89	Bile duct proliferation (HP:0001408)	1.76307928
90	Abnormal biliary tract physiology (HP:0012439)	1.76307928
91	Type 2 muscle fiber atrophy (HP:0003554)	1.76106696
92	Hypoplasia of the pons (HP:0012110)	1.75779272
93	Abnormal ciliary motility (HP:0012262)	1.73900274
94	Hypoplasia of the ulna (HP:0003022)	1.73716353
95	Abnormal hemoglobin (HP:0011902)	1.70644649
96	Attenuation of retinal blood vessels (HP:0007843)	1.70011728
97	Gait imbalance (HP:0002141)	1.69617630
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.68169494
99	Aplastic anemia (HP:0001915)	1.67026362
100	Congenital primary aphakia (HP:0007707)	1.65997288

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.58636121
2	CDK19	3.17666363
3	MAP4K2	2.92923032
4	ADRBK2	2.76108871
5	FRK	2.74378243
6	WNK4	2.68977234
7	TAOK3	2.59284135
8	TLK1	2.42853149
9	NUAK1	2.39156788
10	ZAK	2.37784815
11	GRK1	2.32483536
12	STK16	2.13914556
13	MST4	1.99140047
14	MAP3K12	1.94659738
15	PIK3CA	1.74389753
16	WNK3	1.73946448
17	DYRK2	1.65909603
18	OXSR1	1.65897818
19	PINK1	1.62662826
20	STK39	1.57501572
21	PASK	1.42923905
22	BCKDK	1.42917710
23	VRK2	1.39134114
24	MAPK13	1.33416087
25	MAP4K1	1.32806064
26	VRK1	1.32407155
27	KIT	1.31785171
28	IKBKB	1.30407396
29	EIF2AK3	1.30246509
30	NME1	1.27179003
31	NEK1	1.24691435
32	TEC	1.24532231
33	TIE1	1.22520425
34	MAP2K6	1.20911236
35	CAMKK2	1.16994257
36	INSRR	1.09382837
37	MYLK	1.09261265
38	BMPR2	1.03398868
39	PHKG1	1.02455190
40	PHKG2	1.02455190
41	ITK	1.01370864
42	BMPR1B	0.93226119
43	SYK	0.86241745
44	PLK3	0.84054677
45	FES	0.83350537
46	EIF2AK1	0.82427430
47	CSNK1G3	0.81977508
48	RPS6KA5	0.77413960
49	CSNK1G2	0.75331295
50	FLT3	0.73959752
51	PRKCG	0.72469339
52	DAPK2	0.71807169
53	CSNK1G1	0.70694265
54	NME2	0.69105455
55	TRIM28	0.68876688
56	BTK	0.68726224
57	ADRBK1	0.68578787
58	PRKCQ	0.68238750
59	TSSK6	0.67435220
60	PRKCE	0.67416652
61	TNIK	0.66598065
62	CSNK1A1L	0.66448416
63	GRK6	0.66000353
64	BUB1	0.64390022
65	DAPK3	0.63125508
66	PTK2B	0.62249392
67	CSNK2A2	0.61969811
68	PAK3	0.61452993
69	SRPK1	0.59170818
70	NLK	0.58994146
71	OBSCN	0.58778740
72	CSF1R	0.58234306
73	MAP2K2	0.57649266
74	LYN	0.57421181
75	CDC7	0.54884670
76	PRKACA	0.53994821
77	PLK4	0.50718520
78	CSNK2A1	0.50245257
79	IKBKE	0.48976369
80	AURKB	0.48511405
81	HIPK2	0.47584453
82	CAMK1	0.47120391
83	MAP3K4	0.46589453
84	CSNK1A1	0.46586718
85	EIF2AK2	0.46505853
86	LRRK2	0.43412492
87	PLK1	0.41659468
88	PRKCA	0.41436625
89	LCK	0.40751894
90	PRKCI	0.40348974
91	IGF1R	0.38918308
92	STK11	0.37019553
93	CSNK1E	0.34408007
94	PLK2	0.33700083
95	PRKG1	0.33610621
96	WNK1	0.32786802
97	CDK3	0.32303912
98	CAMK2A	0.32221296
99	ILK	0.32105528
100	CHUK	0.31623234

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.52981771
2	Asthma_Homo sapiens_hsa05310	3.76685766
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.69521085
4	Allograft rejection_Homo sapiens_hsa05330	3.05813123
5	Parkinsons disease_Homo sapiens_hsa05012	2.89853547
6	Protein export_Homo sapiens_hsa03060	2.88626583
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.85311874
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.84017354
9	Proteasome_Homo sapiens_hsa03050	2.70325008
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.60773485
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.60320366
12	RNA polymerase_Homo sapiens_hsa03020	2.21998881
13	Alzheimers disease_Homo sapiens_hsa05010	1.96056086
14	Huntingtons disease_Homo sapiens_hsa05016	1.92805522
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.91723842
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.83886021
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.83072506
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.76617699
19	RNA degradation_Homo sapiens_hsa03018	1.59195758
20	Homologous recombination_Homo sapiens_hsa03440	1.48842092
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.43953467
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42773264
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.38668843
24	Phototransduction_Homo sapiens_hsa04744	1.38472117
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.35051652
26	Primary immunodeficiency_Homo sapiens_hsa05340	1.34408913
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.32917032
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.28893032
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.26727470
30	Basal transcription factors_Homo sapiens_hsa03022	1.24252481
31	One carbon pool by folate_Homo sapiens_hsa00670	1.23042274
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.18380757
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.17600835
34	Propanoate metabolism_Homo sapiens_hsa00640	1.06660448
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02949343
36	Nucleotide excision repair_Homo sapiens_hsa03420	1.01695466
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.01557835
38	Mismatch repair_Homo sapiens_hsa03430	1.00694770
39	Viral myocarditis_Homo sapiens_hsa05416	0.98279551
40	Caffeine metabolism_Homo sapiens_hsa00232	0.96668883
41	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95583529
42	Regulation of autophagy_Homo sapiens_hsa04140	0.91449080
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88148515
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87496894
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.85989034
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84711815
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81809840
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79337223
49	Purine metabolism_Homo sapiens_hsa00230	0.78438939
50	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.76972081
51	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.76861696
52	RNA transport_Homo sapiens_hsa03013	0.75918510
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75856878
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75477434
55	Butanoate metabolism_Homo sapiens_hsa00650	0.70459460
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65715528
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.65233856
58	Retinol metabolism_Homo sapiens_hsa00830	0.64234044
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64232555
60	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63716282
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63477324
62	Spliceosome_Homo sapiens_hsa03040	0.63095178
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61753892
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60685767
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.59936904
66	Nicotine addiction_Homo sapiens_hsa05033	0.59834200
67	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59779484
68	Sulfur metabolism_Homo sapiens_hsa00920	0.58235885
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58133176
70	Peroxisome_Homo sapiens_hsa04146	0.57029609
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56847510
72	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56789288
73	Olfactory transduction_Homo sapiens_hsa04740	0.56739191
74	Metabolic pathways_Homo sapiens_hsa01100	0.55978805
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52544713
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.51085948
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.50134748
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.50091575
79	DNA replication_Homo sapiens_hsa03030	0.49085984
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46816699
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43706895
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39475303
83	Leishmaniasis_Homo sapiens_hsa05140	0.37240473
84	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.35097707
85	Selenocompound metabolism_Homo sapiens_hsa00450	0.34528263
86	Non-homologous end-joining_Homo sapiens_hsa03450	0.32629818
87	Mineral absorption_Homo sapiens_hsa04978	0.31471992
88	Morphine addiction_Homo sapiens_hsa05032	0.31269908
89	Fatty acid degradation_Homo sapiens_hsa00071	0.31239046
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29717543
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.29464184
92	Sulfur relay system_Homo sapiens_hsa04122	0.29006359
93	Base excision repair_Homo sapiens_hsa03410	0.28736270
94	Taste transduction_Homo sapiens_hsa04742	0.28235130
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27713849
96	Serotonergic synapse_Homo sapiens_hsa04726	0.27319693
97	Insulin secretion_Homo sapiens_hsa04911	0.21384604
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.18429004
99	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.18413186
100	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.18154326

RPL21P131

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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