RPL21P132

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of telomere maintenance (GO:0032205)7.12087218
2regulation of isotype switching to IgG isotypes (GO:0048302)6.75316310
3positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)6.70097739
4regulation of telomere maintenance via telomerase (GO:0032210)5.93322241
5regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.91740017
6negative regulation of telomerase activity (GO:0051974)5.39678499
7positive regulation of isotype switching (GO:0045830)5.30310941
8positive regulation of DNA recombination (GO:0045911)5.10638014
9regulation of immunoglobulin secretion (GO:0051023)4.54954529
10regulation of regulatory T cell differentiation (GO:0045589)4.44593217
11DNA damage induced protein phosphorylation (GO:0006975)4.34732670
12ATP synthesis coupled proton transport (GO:0015986)4.34575942
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.34575942
14regulation of podosome assembly (GO:0071801)4.16558340
15positive regulation of B cell mediated immunity (GO:0002714)4.09256939
16positive regulation of immunoglobulin mediated immune response (GO:0002891)4.09256939
17regulation of telomere maintenance (GO:0032204)4.06667853
18regulation of telomerase activity (GO:0051972)4.04983144
19regulation of chronic inflammatory response (GO:0002676)4.03458570
20behavioral response to nicotine (GO:0035095)3.98608975
21activated T cell proliferation (GO:0050798)3.93903082
22positive regulation of chemokine biosynthetic process (GO:0045080)3.93839518
23regulation of helicase activity (GO:0051095)3.88480145
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84273955
25DNA deamination (GO:0045006)3.77160581
26negative regulation of DNA biosynthetic process (GO:2000279)3.76988433
27protein complex biogenesis (GO:0070271)3.75673727
28GTP biosynthetic process (GO:0006183)3.75245302
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65102604
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.65102604
31NADH dehydrogenase complex assembly (GO:0010257)3.65102604
32regulation of isotype switching (GO:0045191)3.53098425
33positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.48059256
34positive regulation of defense response to virus by host (GO:0002230)3.47803672
35positive regulation of interleukin-17 production (GO:0032740)3.47788910
36mitochondrial respiratory chain complex assembly (GO:0033108)3.45578542
37regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.41460238
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.39804508
39positive regulation of immunoglobulin production (GO:0002639)3.38289560
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.36287730
41telomere maintenance via telomerase (GO:0007004)3.36113657
42cellular response to exogenous dsRNA (GO:0071360)3.19496060
43purine-containing compound salvage (GO:0043101)3.10902095
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09567060
45UTP biosynthetic process (GO:0006228)3.07650555
46positive regulation of activated T cell proliferation (GO:0042104)3.07104772
47rRNA modification (GO:0000154)2.99994252
48interferon-gamma production (GO:0032609)2.99797088
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98087460
50regulation of chemokine biosynthetic process (GO:0045073)2.96881143
51ribosomal large subunit biogenesis (GO:0042273)2.96275285
52T cell differentiation involved in immune response (GO:0002292)2.95400277
53alpha-beta T cell differentiation involved in immune response (GO:0002293)2.95400277
54alpha-beta T cell activation involved in immune response (GO:0002287)2.95400277
55peptidyl-histidine modification (GO:0018202)2.92584116
56protein polyglutamylation (GO:0018095)2.90343985
57negative regulation of B cell apoptotic process (GO:0002903)2.89081229
58regulation of immunoglobulin production (GO:0002637)2.87208220
59rRNA methylation (GO:0031167)2.85793863
60regulation of immunoglobulin mediated immune response (GO:0002889)2.83160886
61respiratory chain complex IV assembly (GO:0008535)2.82143707
62positive regulation of fatty acid transport (GO:2000193)2.81272656
63UTP metabolic process (GO:0046051)2.80816231
64water-soluble vitamin biosynthetic process (GO:0042364)2.79401832
65alpha-beta T cell differentiation (GO:0046632)2.78149824
66ventricular trabecula myocardium morphogenesis (GO:0003222)2.75303269
67positive regulation of prostaglandin secretion (GO:0032308)2.74040117
68ribosomal small subunit assembly (GO:0000028)2.71952594
69cytochrome complex assembly (GO:0017004)2.71711110
70regulation of B cell mediated immunity (GO:0002712)2.70789887
71kynurenine metabolic process (GO:0070189)2.70773674
72maturation of 5.8S rRNA (GO:0000460)2.64773053
73piRNA metabolic process (GO:0034587)2.64163119
74positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.63757266
75regulation of MHC class II biosynthetic process (GO:0045346)2.63633419
76purine nucleoside triphosphate biosynthetic process (GO:0009145)2.63288237
77guanosine-containing compound biosynthetic process (GO:1901070)2.62387113
78electron transport chain (GO:0022900)2.61654600
79purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.61615741
80respiratory electron transport chain (GO:0022904)2.60580935
81embryonic hemopoiesis (GO:0035162)2.59533874
82positive regulation of DNA biosynthetic process (GO:2000573)2.58485266
83indole-containing compound catabolic process (GO:0042436)2.58400839
84indolalkylamine catabolic process (GO:0046218)2.58400839
85tryptophan catabolic process (GO:0006569)2.58400839
86signal peptide processing (GO:0006465)2.57759165
87cellular response to ATP (GO:0071318)2.52753463
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50698407
89cellular response to interferon-beta (GO:0035458)2.50689003
90CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.49820569
91positive regulation of T cell migration (GO:2000406)2.48705720
92positive regulation of organelle assembly (GO:1902117)2.48415458
93positive regulation of immune response to tumor cell (GO:0002839)2.44925836
94regulation of immune response to tumor cell (GO:0002837)2.44925836
95regulation of response to tumor cell (GO:0002834)2.44925836
96positive regulation of response to tumor cell (GO:0002836)2.44925836
97positive regulation of interleukin-12 production (GO:0032735)2.42106595
98termination of RNA polymerase I transcription (GO:0006363)2.41749099
99alpha-beta T cell activation (GO:0046631)2.41450002
100glycerophospholipid catabolic process (GO:0046475)2.40719079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.98319583
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.52362180
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.45393334
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.13004850
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01488242
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.99000155
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84233197
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79364596
9VDR_22108803_ChIP-Seq_LS180_Human2.63690481
10ZNF274_21170338_ChIP-Seq_K562_Hela2.57731191
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45728530
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42164672
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.31510207
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.31487892
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27378136
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.26327066
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23915826
18VDR_23849224_ChIP-Seq_CD4+_Human2.11864135
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04747879
20IGF1R_20145208_ChIP-Seq_DFB_Human1.97648194
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.95207791
22ER_23166858_ChIP-Seq_MCF-7_Human1.93420550
23GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.92371111
24TP53_22573176_ChIP-Seq_HFKS_Human1.90305252
25TAF15_26573619_Chip-Seq_HEK293_Human1.86937018
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80787125
27EWS_26573619_Chip-Seq_HEK293_Human1.76174149
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73555417
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.68847349
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68758850
31MYC_18940864_ChIP-ChIP_HL60_Human1.68616268
32FOXP3_21729870_ChIP-Seq_TREG_Human1.62554590
33TDRD3_21172665_ChIP-Seq_MCF-7_Human1.58717194
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56502818
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53810944
36ELK1_19687146_ChIP-ChIP_HELA_Human1.52569278
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50516123
38GATA3_26560356_Chip-Seq_TH2_Human1.45891298
39LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39717268
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38778340
41GBX2_23144817_ChIP-Seq_PC3_Human1.36557250
42AR_20517297_ChIP-Seq_VCAP_Human1.35029203
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33959809
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33885374
45CBP_20019798_ChIP-Seq_JUKART_Human1.33885374
46FUS_26573619_Chip-Seq_HEK293_Human1.30183205
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29587273
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24551220
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24480035
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.24200424
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24200424
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22547911
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19999189
54ERA_21632823_ChIP-Seq_H3396_Human1.18356813
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17063358
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17000513
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16108819
58NCOR_22424771_ChIP-Seq_293T_Human1.16024765
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13075968
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12406604
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10933634
62FOXH1_21741376_ChIP-Seq_EPCs_Human1.09412665
63P300_19829295_ChIP-Seq_ESCs_Human1.08578325
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08124426
65SOX2_19829295_ChIP-Seq_ESCs_Human1.07970932
66NANOG_19829295_ChIP-Seq_ESCs_Human1.07970932
67TCF4_22108803_ChIP-Seq_LS180_Human1.06939993
68EZH2_22144423_ChIP-Seq_EOC_Human1.06847531
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06802238
70TAF2_19829295_ChIP-Seq_ESCs_Human1.06419933
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.05845535
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.05584560
73HOXB7_26014856_ChIP-Seq_BT474_Human1.03134334
74P53_21459846_ChIP-Seq_SAOS-2_Human1.02470995
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01454008
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00468146
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.00237197
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00222978
79OCT4_20526341_ChIP-Seq_ESCs_Human0.99760773
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98674583
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.98298334
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95915611
83RUNX_20019798_ChIP-Seq_JUKART_Human0.94620012
84SOX2_21211035_ChIP-Seq_LN229_Human0.93103851
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92932638
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92357784
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.92239877
88NANOG_20526341_ChIP-Seq_ESCs_Human0.92078527
89MYC_18555785_ChIP-Seq_MESCs_Mouse0.91802863
90STAT1_20625510_ChIP-Seq_HELA_Human0.91553373
91P300_27268052_Chip-Seq_Bcells_Human0.90792652
92DCP1A_22483619_ChIP-Seq_HELA_Human0.90498100
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90446227
94TP63_17297297_ChIP-ChIP_HaCaT_Human0.90445805
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89460125
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.88914382
97ERG_20517297_ChIP-Seq_VCAP_Human0.88622733
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88242010
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86819227
100RBPJ_21746931_ChIP-Seq_IB4_Human0.86469954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.60429151
2MP0005671_abnormal_response_to3.90540807
3MP0001873_stomach_inflammation3.35566343
4MP0001348_abnormal_lacrimal_gland2.96863356
5MP0002876_abnormal_thyroid_physiology2.95237849
6MP0003646_muscle_fatigue2.93049523
7MP0002163_abnormal_gland_morphology2.88068071
8MP0000685_abnormal_immune_system2.78774434
9MP0001986_abnormal_taste_sensitivity2.70177995
10MP0008877_abnormal_DNA_methylation2.62470860
11MP0008875_abnormal_xenobiotic_pharmacok2.55361166
12MP0009333_abnormal_splenocyte_physiolog2.26173032
13MP0002102_abnormal_ear_morphology2.19037722
14MP0003763_abnormal_thymus_physiology2.00807025
15MP0004147_increased_porphyrin_level1.99992947
16MP0009785_altered_susceptibility_to1.95374879
17MP0002148_abnormal_hypersensitivity_rea1.93179734
18MP0002837_dystrophic_cardiac_calcinosis1.89796493
19MP0008872_abnormal_physiological_respon1.87034072
20MP0005379_endocrine/exocrine_gland_phen1.83269529
21MP0001790_abnormal_immune_system1.81581472
22MP0005387_immune_system_phenotype1.81581472
23MP0002166_altered_tumor_susceptibility1.69509758
24MP0004133_heterotaxia1.66819222
25MP0005000_abnormal_immune_tolerance1.65788927
26MP0006082_CNS_inflammation1.65296073
27MP0001800_abnormal_humoral_immune1.64435791
28MP0001853_heart_inflammation1.59561184
29MP0002006_tumorigenesis1.57855465
30MP0001968_abnormal_touch/_nociception1.55339791
31MP0008775_abnormal_heart_ventricle1.53789733
32MP0006072_abnormal_retinal_apoptosis1.48286830
33MP0003436_decreased_susceptibility_to1.47964945
34MP0005645_abnormal_hypothalamus_physiol1.47898750
35MP0003195_calcinosis1.38705641
36MP0005646_abnormal_pituitary_gland1.36394571
37MP0003880_abnormal_central_pattern1.33003061
38MP0006276_abnormal_autonomic_nervous1.29322074
39MP0006292_abnormal_olfactory_placode1.28971738
40MP0000569_abnormal_digit_pigmentation1.28268309
41MP0002254_reproductive_system_inflammat1.27653136
42MP0005551_abnormal_eye_electrophysiolog1.24537572
43MP0009764_decreased_sensitivity_to1.24235976
44MP0004145_abnormal_muscle_electrophysio1.24058195
45MP0010155_abnormal_intestine_physiology1.22293444
46MP0002138_abnormal_hepatobiliary_system1.21367699
47MP0002723_abnormal_immune_serum1.18903940
48MP0003300_gastrointestinal_ulcer1.17693832
49MP0002420_abnormal_adaptive_immunity1.16855552
50MP0001819_abnormal_immune_cell1.16779266
51MP0002272_abnormal_nervous_system1.14617485
52MP0002452_abnormal_antigen_presenting1.13909410
53MP0004270_analgesia1.12953503
54MP0005310_abnormal_salivary_gland1.12285579
55MP0002277_abnormal_respiratory_mucosa1.11917118
56MP0002405_respiratory_system_inflammati1.09301103
57MP0005025_abnormal_response_to1.08300634
58MP0009379_abnormal_foot_pigmentation1.08206349
59MP0001845_abnormal_inflammatory_respons1.03902015
60MP0000372_irregular_coat_pigmentation1.03521658
61MP0002736_abnormal_nociception_after1.02779281
62MP0002693_abnormal_pancreas_physiology1.02409484
63MP0003866_abnormal_defecation1.01001168
64MP0001764_abnormal_homeostasis0.98974352
65MP0003806_abnormal_nucleotide_metabolis0.96878156
66MP0008995_early_reproductive_senescence0.96736414
67MP0009745_abnormal_behavioral_response0.96189778
68MP0004782_abnormal_surfactant_physiolog0.95379953
69MP0006036_abnormal_mitochondrial_physio0.94960204
70MP0004885_abnormal_endolymph0.94330859
71MP0003724_increased_susceptibility_to0.94326751
72MP0004043_abnormal_pH_regulation0.92206387
73MP0003787_abnormal_imprinting0.91574744
74MP0002090_abnormal_vision0.91413611
75MP0005085_abnormal_gallbladder_physiolo0.91322936
76MP0001663_abnormal_digestive_system0.88262689
77MP0001502_abnormal_circadian_rhythm0.87343300
78MP0001919_abnormal_reproductive_system0.86600632
79MP0008058_abnormal_DNA_repair0.80995099
80MP0005253_abnormal_eye_physiology0.79274059
81MP0003186_abnormal_redox_activity0.78644761
82MP0002419_abnormal_innate_immunity0.76872137
83MP0002938_white_spotting0.73712821
84MP0005075_abnormal_melanosome_morpholog0.72841047
85MP0001346_abnormal_lacrimal_gland0.71814893
86MP0001501_abnormal_sleep_pattern0.71682439
87MP0001661_extended_life_span0.70963676
88MP0000230_abnormal_systemic_arterial0.69512175
89MP0000604_amyloidosis0.67723133
90MP0005448_abnormal_energy_balance0.66916221
91MP0001905_abnormal_dopamine_level0.66351514
92MP0003786_premature_aging0.66225189
93MP0005423_abnormal_somatic_nervous0.66079181
94MP0004142_abnormal_muscle_tone0.65720911
95MP0005332_abnormal_amino_acid0.65441667
96MP0005389_reproductive_system_phenotype0.63608988
97MP0001970_abnormal_pain_threshold0.63040922
98MP0002735_abnormal_chemical_nociception0.62965446
99MP0000716_abnormal_immune_system0.62564126
100MP0004484_altered_response_of0.62483644

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.49969048
2Autoimmune thrombocytopenia (HP:0001973)4.35432016
3Autoimmune hemolytic anemia (HP:0001890)4.00439745
4Increased neuronal autofluorescent lipopigment (HP:0002074)3.58488900
5Mitochondrial inheritance (HP:0001427)3.47136784
6Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.43425535
7Congenital stationary night blindness (HP:0007642)3.43178159
8Pancreatic cysts (HP:0001737)3.36663728
9Increased CSF lactate (HP:0002490)3.36204239
10Hepatocellular necrosis (HP:0001404)3.33170741
11Congenital, generalized hypertrichosis (HP:0004540)3.29629608
12Increased IgM level (HP:0003496)3.20841480
13Acute necrotizing encephalopathy (HP:0006965)3.19912235
14Lipid accumulation in hepatocytes (HP:0006561)3.19862070
15Abnormality of T cell physiology (HP:0011840)3.17126780
16IgG deficiency (HP:0004315)3.14121987
17Hepatic necrosis (HP:0002605)3.10435392
18Increased hepatocellular lipid droplets (HP:0006565)3.08946770
19Testicular atrophy (HP:0000029)3.02027292
20Aplasia/Hypoplasia of the spleen (HP:0010451)3.00824629
21Asplenia (HP:0001746)2.99347306
22Abnormality of midbrain morphology (HP:0002418)2.98366301
23Molar tooth sign on MRI (HP:0002419)2.98366301
24Alveolar cell carcinoma (HP:0006519)2.84755626
25Visual hallucinations (HP:0002367)2.80860790
26Progressive macrocephaly (HP:0004481)2.69192969
27Abnormal mitochondria in muscle tissue (HP:0008316)2.68128933
28Increased cerebral lipofuscin (HP:0011813)2.66603819
293-Methylglutaconic aciduria (HP:0003535)2.65795291
30Esophageal atresia (HP:0002032)2.59611507
31Acute encephalopathy (HP:0006846)2.57909676
32Increased serum lactate (HP:0002151)2.56992867
33Parakeratosis (HP:0001036)2.51624444
34Abnormality of T cells (HP:0002843)2.47292616
35Abnormality of the prostate (HP:0008775)2.41437320
36Abnormality of the renal cortex (HP:0011035)2.36393789
37Neoplasm of the tracheobronchial system (HP:0100552)2.35139226
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32961908
39Optic disc pallor (HP:0000543)2.25032325
40Pancreatic fibrosis (HP:0100732)2.24229600
41Elevated erythrocyte sedimentation rate (HP:0003565)2.23896010
42Nephronophthisis (HP:0000090)2.21620572
43Retrobulbar optic neuritis (HP:0100654)2.21258587
44Optic neuritis (HP:0100653)2.21258587
45Humeroradial synostosis (HP:0003041)2.19504540
46Synostosis involving the elbow (HP:0003938)2.19504540
47Increased serum pyruvate (HP:0003542)2.16116618
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13845562
49Keratoconjunctivitis (HP:0001096)2.11899020
50Abnormal respiratory motile cilium morphology (HP:0005938)2.11565766
51Abnormal respiratory epithelium morphology (HP:0012253)2.11565766
52Abnormal biliary tract physiology (HP:0012439)2.09960637
53Bile duct proliferation (HP:0001408)2.09960637
54Prostate neoplasm (HP:0100787)2.07968718
55Pendular nystagmus (HP:0012043)2.07298390
56Abnormality of the proximal phalanges of the hand (HP:0009834)2.06313712
57Abnormal rod and cone electroretinograms (HP:0008323)2.06310879
58Renal Fanconi syndrome (HP:0001994)2.06057273
59Hypoplasia of the ulna (HP:0003022)2.05904235
60Abolished electroretinogram (ERG) (HP:0000550)2.04448349
61Cerebral edema (HP:0002181)2.04207135
62Abnormal drinking behavior (HP:0030082)2.03367537
63Polydipsia (HP:0001959)2.03367537
64Abnormality of cells of the erythroid lineage (HP:0012130)2.01985589
65Aplasia/Hypoplasia of the ulna (HP:0006495)2.00626315
66Exertional dyspnea (HP:0002875)2.00072037
67Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.99610749
68Fibular aplasia (HP:0002990)1.98766141
69Decreased circulating renin level (HP:0003351)1.98762111
70Abnormality of the renal medulla (HP:0100957)1.97879622
71Renal cortical cysts (HP:0000803)1.95141309
72Abnormality of the middle phalanges of the toes (HP:0010183)1.94977307
73Abnormality of the aortic arch (HP:0012303)1.93642091
74Abnormality of urine glucose concentration (HP:0011016)1.91918838
75Glycosuria (HP:0003076)1.91918838
76Central scotoma (HP:0000603)1.89548033
77Supernumerary spleens (HP:0009799)1.87389095
78Mesomelia (HP:0003027)1.87202205
79Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86560772
80Aplasia/Hypoplasia involving the musculature (HP:0001460)1.85604517
81Abnormality of the phalanges of the 5th finger (HP:0004213)1.85227355
82Abnormal delayed hypersensitivity skin test (HP:0002963)1.84219310
83Type II lissencephaly (HP:0007260)1.83729493
84Dyschromatopsia (HP:0007641)1.83645005
85Pulmonary infiltrates (HP:0002113)1.82973065
86Increased intramyocellular lipid droplets (HP:0012240)1.82571163
87Symphalangism affecting the phalanges of the hand (HP:0009773)1.81466856
88True hermaphroditism (HP:0010459)1.80874798
89Constricted visual fields (HP:0001133)1.79852781
90B lymphocytopenia (HP:0010976)1.79125899
91Radial bowing (HP:0002986)1.78188291
92Potter facies (HP:0002009)1.76768983
93Facial shape deformation (HP:0011334)1.76768983
94Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76135148
95Aplasia/hypoplasia of the uterus (HP:0008684)1.74962749
96Chronic sinusitis (HP:0011109)1.74882831
97Hypoproteinemia (HP:0003075)1.74483416
98Abnormal number of erythroid precursors (HP:0012131)1.73200224
99Aplasia cutis congenita (HP:0001057)1.72747142
100Abnormality of the pons (HP:0007361)1.71646854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK26.98338427
2MAP2K65.20387492
3TLK14.30946056
4NME13.99481265
5TXK3.35717772
6WNK42.69705864
7ADRBK22.50812734
8MAP4K22.45365196
9MAP3K52.33935982
10NUAK12.17579334
11FRK2.12045429
12GRK11.95307765
13PNCK1.85601596
14ZAK1.73259655
15TSSK61.61847695
16TAOK31.57789317
17MAP4K11.55895067
18BMPR21.52641246
19PINK11.49117730
20SIK21.48312967
21DAPK21.38996035
22AKT31.37073852
23MAP3K121.33594728
24STK391.33457428
25OXSR11.29090966
26VRK21.26254249
27EIF2AK31.17990229
28EIF2AK11.17348285
29IKBKB1.10506979
30PIK3CA1.01863734
31NEK10.94032983
32TEC0.89908996
33WNK10.85818119
34WNK30.84481075
35PAK30.84067691
36MAPKAPK30.83275450
37MST40.79429605
38KIT0.78927731
39ITK0.78531163
40BCR0.77553908
41SRPK10.76358095
42CAMKK20.74526281
43IKBKE0.68646335
44MAP3K80.68302910
45CSNK1G30.66750610
46GRK60.63737259
47DYRK20.63606553
48STK40.62651473
49HIPK20.59367429
50TIE10.57717203
51CSNK1A1L0.56101660
52MKNK20.53700096
53CSNK1G20.53658000
54INSRR0.52587027
55TGFBR20.52208944
56VRK10.50644278
57STK160.50094561
58CSNK1A10.49894609
59ADRBK10.49719273
60DAPK10.49259500
61LYN0.46919238
62BRSK20.46515010
63PHKG20.45965067
64PHKG10.45965067
65BTK0.44676145
66CASK0.43882291
67ACVR1B0.43599495
68PLK40.42978961
69EIF2AK20.42149847
70CSNK1G10.41757402
71MAP3K140.41686930
72PRKCG0.41299238
73PRKCE0.39960828
74TAF10.39771274
75PRKCQ0.38459600
76WEE10.38154468
77JAK30.36893738
78FLT30.36458945
79MYLK0.35640118
80TNIK0.35151950
81FES0.32368327
82MAP3K110.31269270
83LCK0.31268699
84PLK30.31026612
85MAP3K40.30170428
86TYK20.30128250
87RPS6KB10.29857102
88MAPKAPK50.29347546
89MKNK10.28350619
90RPS6KB20.27451180
91BCKDK0.26813320
92MAP2K20.26051409
93ATR0.25901163
94SYK0.25412183
95IGF1R0.25201712
96CDK190.23943261
97TRIM280.23722954
98CSNK2A20.22885568
99CSK0.21886260
100RIPK40.21840500

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.69219090
2Allograft rejection_Homo sapiens_hsa053304.16717367
3Autoimmune thyroid disease_Homo sapiens_hsa053203.69211804
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.56870077
5Proteasome_Homo sapiens_hsa030503.11099956
6Graft-versus-host disease_Homo sapiens_hsa053323.08016436
7Type I diabetes mellitus_Homo sapiens_hsa049403.06565342
8Oxidative phosphorylation_Homo sapiens_hsa001902.63603240
9Ribosome_Homo sapiens_hsa030102.55052023
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.50528577
11Protein export_Homo sapiens_hsa030602.23109649
12Parkinsons disease_Homo sapiens_hsa050122.04121550
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87498236
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83296295
15RNA polymerase_Homo sapiens_hsa030201.57566341
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.57460607
17Rheumatoid arthritis_Homo sapiens_hsa053231.53992903
18Linoleic acid metabolism_Homo sapiens_hsa005911.53559474
19Primary immunodeficiency_Homo sapiens_hsa053401.53439708
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42824866
21Antigen processing and presentation_Homo sapiens_hsa046121.42790164
22Cardiac muscle contraction_Homo sapiens_hsa042601.39195636
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38387125
24Alzheimers disease_Homo sapiens_hsa050101.38371788
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37231820
26Homologous recombination_Homo sapiens_hsa034401.32339915
27Hematopoietic cell lineage_Homo sapiens_hsa046401.29631577
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28150397
29Huntingtons disease_Homo sapiens_hsa050161.27140456
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17661257
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.16441034
32Phototransduction_Homo sapiens_hsa047441.16345941
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.15529437
34RNA degradation_Homo sapiens_hsa030181.13929054
35Basal transcription factors_Homo sapiens_hsa030221.09974363
36T cell receptor signaling pathway_Homo sapiens_hsa046601.08564007
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.03968202
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99279189
39Ether lipid metabolism_Homo sapiens_hsa005650.97299597
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96629783
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88559742
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87534236
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85796699
44Pyrimidine metabolism_Homo sapiens_hsa002400.85669044
45Regulation of autophagy_Homo sapiens_hsa041400.81479126
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80307330
47Selenocompound metabolism_Homo sapiens_hsa004500.79181131
48Nitrogen metabolism_Homo sapiens_hsa009100.78366456
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77274258
50Butanoate metabolism_Homo sapiens_hsa006500.76344263
51Fanconi anemia pathway_Homo sapiens_hsa034600.74889158
52Fat digestion and absorption_Homo sapiens_hsa049750.74523902
53Mineral absorption_Homo sapiens_hsa049780.73235763
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.71949056
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.71768764
56Spliceosome_Homo sapiens_hsa030400.70404272
57One carbon pool by folate_Homo sapiens_hsa006700.69521066
58Nicotine addiction_Homo sapiens_hsa050330.66723805
59Systemic lupus erythematosus_Homo sapiens_hsa053220.64432827
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64185221
61Arachidonic acid metabolism_Homo sapiens_hsa005900.64115176
62Tryptophan metabolism_Homo sapiens_hsa003800.64107896
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64046789
64TNF signaling pathway_Homo sapiens_hsa046680.59799811
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56966401
66Measles_Homo sapiens_hsa051620.56709266
67Vitamin B6 metabolism_Homo sapiens_hsa007500.56689108
68Caffeine metabolism_Homo sapiens_hsa002320.56193733
69RNA transport_Homo sapiens_hsa030130.55155227
70Purine metabolism_Homo sapiens_hsa002300.52315178
71Viral myocarditis_Homo sapiens_hsa054160.51425183
72Sulfur metabolism_Homo sapiens_hsa009200.49675767
73Toxoplasmosis_Homo sapiens_hsa051450.47935730
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47921695
75African trypanosomiasis_Homo sapiens_hsa051430.47745389
76Mismatch repair_Homo sapiens_hsa034300.47736959
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45329977
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.44619991
79Steroid biosynthesis_Homo sapiens_hsa001000.44092290
80Staphylococcus aureus infection_Homo sapiens_hsa051500.43200323
81Chemical carcinogenesis_Homo sapiens_hsa052040.42972738
82Retinol metabolism_Homo sapiens_hsa008300.42964524
83Dorso-ventral axis formation_Homo sapiens_hsa043200.37455758
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37222710
85Vitamin digestion and absorption_Homo sapiens_hsa049770.33490050
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33214051
87Metabolic pathways_Homo sapiens_hsa011000.31784169
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.30441449
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29546187
90Taste transduction_Homo sapiens_hsa047420.28570356
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27755604
92Non-homologous end-joining_Homo sapiens_hsa034500.27676997
93Nucleotide excision repair_Homo sapiens_hsa034200.27568066
94Leishmaniasis_Homo sapiens_hsa051400.25613692
95Influenza A_Homo sapiens_hsa051640.25068395
96Propanoate metabolism_Homo sapiens_hsa006400.23845883
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23390613
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.23164138
99Herpes simplex infection_Homo sapiens_hsa051680.23039898
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22198552

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