ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	7.15058399
2	mitochondrial calcium ion transport (GO:0006851)	6.87351139
3	muscle filament sliding (GO:0030049)	5.93929999
4	actin-myosin filament sliding (GO:0033275)	5.93929999
5	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.66828654
6	NADH dehydrogenase complex assembly (GO:0010257)	5.66828654
7	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.66828654
8	protein complex biogenesis (GO:0070271)	5.28543927
9	regulation of oxidative phosphorylation (GO:0002082)	5.21349695
10	actin-mediated cell contraction (GO:0070252)	5.06912670
11	ATP synthesis coupled proton transport (GO:0015986)	5.04870375
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.04870375
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.82203504
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.68182487
15	mitochondrial respiratory chain complex assembly (GO:0033108)	4.64775908
16	nonmotile primary cilium assembly (GO:0035058)	4.62782227
17	mitochondrial calcium ion homeostasis (GO:0051560)	4.52166834
18	ribosomal small subunit assembly (GO:0000028)	4.37839646
19	regulation of cilium movement (GO:0003352)	4.25616204
20	plasma membrane fusion (GO:0045026)	4.19306581
21	myoblast fusion (GO:0007520)	4.19254726
22	skeletal muscle contraction (GO:0003009)	4.17437565
23	respiratory electron transport chain (GO:0022904)	4.02677259
24	electron transport chain (GO:0022900)	4.00814559
25	cellular protein complex localization (GO:0034629)	3.92022507
26	viral transcription (GO:0019083)	3.85817293
27	signal peptide processing (GO:0006465)	3.81486874
28	translational termination (GO:0006415)	3.79405588
29	behavioral response to nicotine (GO:0035095)	3.77196788
30	negative regulation of heart growth (GO:0061117)	3.74455485
31	negative regulation of cardiac muscle tissue growth (GO:0055022)	3.74455485
32	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	3.70349683
33	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.67626519
34	syncytium formation by plasma membrane fusion (GO:0000768)	3.63945565
35	cotranslational protein targeting to membrane (GO:0006613)	3.62800359
36	respiratory chain complex IV assembly (GO:0008535)	3.57490174
37	positive regulation of transcription regulatory region DNA binding (GO:2000679)	3.54051693
38	artery smooth muscle contraction (GO:0014824)	3.53954955
39	protein targeting to ER (GO:0045047)	3.53007212
40	negative regulation of potassium ion transmembrane transport (GO:1901380)	3.43690216
41	protein localization to endoplasmic reticulum (GO:0070972)	3.36251746
42	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.34648193
43	L-serine metabolic process (GO:0006563)	3.33900150
44	syncytium formation (GO:0006949)	3.31303701
45	hydrogen ion transmembrane transport (GO:1902600)	3.24094297
46	oxidative phosphorylation (GO:0006119)	3.14925841
47	synapsis (GO:0007129)	3.13851158
48	synaptic transmission, cholinergic (GO:0007271)	3.12512718
49	lateral ventricle development (GO:0021670)	3.11419091
50	actin filament-based movement (GO:0030048)	3.09782098
51	multicellular organismal movement (GO:0050879)	3.08327802
52	musculoskeletal movement (GO:0050881)	3.08327802
53	proton transport (GO:0015992)	3.06538343
54	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.06085130
55	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.06085130
56	hydrogen transport (GO:0006818)	3.00756515
57	myoblast migration (GO:0051451)	2.99677365
58	positive regulation of granulocyte differentiation (GO:0030854)	2.98368346
59	water-soluble vitamin biosynthetic process (GO:0042364)	2.96782465
60	tonic smooth muscle contraction (GO:0014820)	2.94549014
61	indolalkylamine metabolic process (GO:0006586)	2.94401722
62	cytochrome complex assembly (GO:0017004)	2.94260318
63	translational elongation (GO:0006414)	2.93142555
64	ATP biosynthetic process (GO:0006754)	2.92133967
65	response to muscle activity (GO:0014850)	2.90828714
66	protein complex localization (GO:0031503)	2.90817560
67	axoneme assembly (GO:0035082)	2.90338283
68	DNA integration (GO:0015074)	2.89602824
69	cellular protein complex disassembly (GO:0043624)	2.88536022
70	norepinephrine metabolic process (GO:0042415)	2.84480891
71	tyrosine metabolic process (GO:0006570)	2.84479732
72	protein-cofactor linkage (GO:0018065)	2.83607724
73	cellular response to exogenous dsRNA (GO:0071360)	2.82600972
74	regulation of cellular respiration (GO:0043457)	2.82072326
75	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.80588458
76	regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)	2.77497263
77	regulation of sarcomere organization (GO:0060297)	2.75852566
78	cytidine metabolic process (GO:0046087)	2.75682851
79	cytidine catabolic process (GO:0006216)	2.75682851
80	cytidine deamination (GO:0009972)	2.75682851
81	regulation of chromatin binding (GO:0035561)	2.75591699
82	translational initiation (GO:0006413)	2.75118450
83	positive regulation of defense response to virus by host (GO:0002230)	2.75022209
84	viral life cycle (GO:0019058)	2.73809978
85	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.70545288
86	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.70000582
87	alpha-beta T cell activation involved in immune response (GO:0002287)	2.70000582
88	T cell differentiation involved in immune response (GO:0002292)	2.70000582
89	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.69950864
90	T-helper cell differentiation (GO:0042093)	2.69950864
91	serotonin metabolic process (GO:0042428)	2.68270520
92	translation (GO:0006412)	2.67256464
93	striated muscle contraction (GO:0006941)	2.67048902
94	ribonucleoprotein complex disassembly (GO:0032988)	2.66976591
95	negative regulation of cardiac muscle hypertrophy (GO:0010614)	2.66035979
96	protein prenylation (GO:0018342)	2.64760956
97	prenylation (GO:0097354)	2.64760956
98	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.64173502
99	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.63931276
100	negative regulation of appetite (GO:0032099)	2.62142966

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.68318128
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.48834964
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.88031448
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.57404612
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.05284631
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.58097556
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53346577
8	ELK1_19687146_ChIP-ChIP_HELA_Human	2.53300920
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.52592578
10	VDR_22108803_ChIP-Seq_LS180_Human	2.26690830
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.20560819
12	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.11245504
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.08803935
14	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.04432584
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.03690691
16	EWS_26573619_Chip-Seq_HEK293_Human	2.03433785
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93557226
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92334074
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.89914458
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.83291796
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.81868915
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.80739689
23	FUS_26573619_Chip-Seq_HEK293_Human	1.72825979
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.71108618
25	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.69750817
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63601047
27	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.62615895
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.62204332
29	GATA1_22025678_ChIP-Seq_K562_Human	1.60857503
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.58344197
31	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.55886069
32	NCOR_22424771_ChIP-Seq_293T_Human	1.52573664
33	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.51313850
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.51064605
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49003884
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.48960778
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48118870
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47581526
39	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.43433291
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42409029
41	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.41979325
42	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35605502
43	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.32903858
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32413505
45	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.32188497
46	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.30793836
47	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.27772844
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.25734794
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23397170
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.23382798
51	RBPJ_21746931_ChIP-Seq_IB4_Human	1.22873548
52	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.20553762
53	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.18949994
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.18236503
55	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.17915188
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.17858223
57	ERA_21632823_ChIP-Seq_H3396_Human	1.17453001
58	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.16756781
59	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.16592436
60	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.16047836
61	NFYA_21822215_ChIP-Seq_K562_Human	1.15998463
62	P300_19829295_ChIP-Seq_ESCs_Human	1.15521933
63	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.14498116
64	NFYB_21822215_ChIP-Seq_K562_Human	1.14263564
65	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.13922966
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13562698
67	CBP_20019798_ChIP-Seq_JUKART_Human	1.12892779
68	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12892779
69	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.12747705
70	P53_22387025_ChIP-Seq_ESCs_Mouse	1.12474272
71	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.12247819
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11794381
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11794381
74	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.11431345
75	PHF8_20622853_ChIP-Seq_HELA_Human	1.11080608
76	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.10846499
77	P300_18555785_Chip-Seq_ESCs_Mouse	1.10485275
78	GATA3_26560356_Chip-Seq_TH2_Human	1.07384272
79	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.06517333
80	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.06230538
81	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.05895316
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05627422
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03706245
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02579452
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02304851
86	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.01735039
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.01735039
88	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.00821811
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99227153
90	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98867797
91	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98821309
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98497637
93	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.95002626
94	AR_20517297_ChIP-Seq_VCAP_Human	0.94713113
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94665195
96	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.94477217
97	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94477217
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.93930027
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.93182643
100	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.92487574

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000749_muscle_degeneration	4.39281874
2	MP0003806_abnormal_nucleotide_metabolis	3.64470840
3	MP0004145_abnormal_muscle_electrophysio	3.03956240
4	MP0005171_absent_coat_pigmentation	2.80747297
5	MP0008789_abnormal_olfactory_epithelium	2.77441191
6	MP0002163_abnormal_gland_morphology	2.70672264
7	MP0002653_abnormal_ependyma_morphology	2.64540298
8	MP0009379_abnormal_foot_pigmentation	2.55934080
9	MP0009384_cardiac_valve_regurgitation	2.50720339
10	MP0005645_abnormal_hypothalamus_physiol	2.30146491
11	MP0004885_abnormal_endolymph	2.28582038
12	MP0001529_abnormal_vocalization	2.19885282
13	MP0002837_dystrophic_cardiac_calcinosis	2.16243340
14	MP0005503_abnormal_tendon_morphology	2.15840694
15	MP0006072_abnormal_retinal_apoptosis	2.06429781
16	MP0000372_irregular_coat_pigmentation	2.04891667
17	MP0004484_altered_response_of	1.95302960
18	MP0001968_abnormal_touch/_nociception	1.92219935
19	MP0002822_catalepsy	1.87711499
20	MP0001873_stomach_inflammation	1.86658830
21	MP0003786_premature_aging	1.81253419
22	MP0001542_abnormal_bone_strength	1.79708382
23	MP0005075_abnormal_melanosome_morpholog	1.79396362
24	MP0001986_abnormal_taste_sensitivity	1.77269652
25	MP0009697_abnormal_copulation	1.75358958
26	MP0005499_abnormal_olfactory_system	1.74786114
27	MP0005394_taste/olfaction_phenotype	1.74786114
28	MP0003195_calcinosis	1.69841754
29	MP0003646_muscle_fatigue	1.69460920
30	MP0005389_reproductive_system_phenotype	1.66071899
31	MP0008877_abnormal_DNA_methylation	1.63066862
32	MP0006036_abnormal_mitochondrial_physio	1.62716509
33	MP0001984_abnormal_olfaction	1.60304756
34	MP0002938_white_spotting	1.59074058
35	MP0008872_abnormal_physiological_respon	1.58798735
36	MP0002009_preneoplasia	1.54608095
37	MP0002160_abnormal_reproductive_system	1.54089649
38	MP0002108_abnormal_muscle_morphology	1.52449989
39	MP0004133_heterotaxia	1.51764968
40	MP0008875_abnormal_xenobiotic_pharmacok	1.48801572
41	MP0001485_abnormal_pinna_reflex	1.46428979
42	MP0004233_abnormal_muscle_weight	1.40567262
43	MP0005551_abnormal_eye_electrophysiolog	1.39931165
44	MP0005379_endocrine/exocrine_gland_phen	1.39629953
45	MP0004036_abnormal_muscle_relaxation	1.36687419
46	MP0002933_joint_inflammation	1.29776102
47	MP0005367_renal/urinary_system_phenotyp	1.26992091
48	MP0000516_abnormal_urinary_system	1.26992091
49	MP0004084_abnormal_cardiac_muscle	1.25454892
50	MP0010030_abnormal_orbit_morphology	1.23184928
51	MP0003186_abnormal_redox_activity	1.17880458
52	MP0002736_abnormal_nociception_after	1.17045671
53	MP0001919_abnormal_reproductive_system	1.15967710
54	MP0008007_abnormal_cellular_replicative	1.13155885
55	MP0009780_abnormal_chondrocyte_physiolo	1.12467925
56	MP0000427_abnormal_hair_cycle	1.10415813
57	MP0004742_abnormal_vestibular_system	1.09163911
58	MP0003137_abnormal_impulse_conducting	1.01812044
59	MP0005377_hearing/vestibular/ear_phenot	1.00830100
60	MP0003878_abnormal_ear_physiology	1.00830100
61	MP0001299_abnormal_eye_distance/	0.98330269
62	MP0000759_abnormal_skeletal_muscle	0.97956322
63	MP0005410_abnormal_fertilization	0.97829193
64	MP0005387_immune_system_phenotype	0.97739591
65	MP0001790_abnormal_immune_system	0.97739591
66	MP0005330_cardiomyopathy	0.96904188
67	MP0003315_abnormal_perineum_morphology	0.95807396
68	MP0003938_abnormal_ear_development	0.95440445
69	MP0006054_spinal_hemorrhage	0.95003272
70	MP0002269_muscular_atrophy	0.94696475
71	MP0006292_abnormal_olfactory_placode	0.92438902
72	MP0005646_abnormal_pituitary_gland	0.90184085
73	MP0003567_abnormal_fetal_cardiomyocyte	0.89126598
74	MP0005369_muscle_phenotype	0.88741493
75	MP0003279_aneurysm	0.88415747
76	MP0009250_abnormal_appendicular_skeleto	0.88182546
77	MP0002277_abnormal_respiratory_mucosa	0.88045568
78	MP0004381_abnormal_hair_follicle	0.86500720
79	MP0005620_abnormal_muscle_contractility	0.85230923
80	MP0005253_abnormal_eye_physiology	0.85022995
81	MP0002102_abnormal_ear_morphology	0.83208259
82	MP0008775_abnormal_heart_ventricle	0.82392265
83	MP0001764_abnormal_homeostasis	0.73900401
84	MP0000750_abnormal_muscle_regeneration	0.73545368
85	MP0002106_abnormal_muscle_physiology	0.72802723
86	MP0003123_paternal_imprinting	0.72267450
87	MP0000747_muscle_weakness	0.71516041
88	MP0000647_abnormal_sebaceous_gland	0.71490293
89	MP0004142_abnormal_muscle_tone	0.69326830
90	MP0002233_abnormal_nose_morphology	0.69292718
91	MP0005671_abnormal_response_to	0.68999292
92	MP0001970_abnormal_pain_threshold	0.68620972
93	MP0008995_early_reproductive_senescence	0.68007639
94	MP0005452_abnormal_adipose_tissue	0.67995840
95	MP0002733_abnormal_thermal_nociception	0.67399669
96	MP0005386_behavior/neurological_phenoty	0.66007520
97	MP0004924_abnormal_behavior	0.66007520
98	MP0001905_abnormal_dopamine_level	0.64069459
99	MP0002098_abnormal_vibrissa_morphology	0.63545127
100	MP0001929_abnormal_gametogenesis	0.63331928

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Popliteal pterygium (HP:0009756)	7.37191941
2	Type 2 muscle fiber atrophy (HP:0003554)	6.99202169
3	Muscle fiber atrophy (HP:0100295)	6.27502350
4	Amniotic constriction ring (HP:0009775)	6.03207581
5	Abnormality of placental membranes (HP:0011409)	6.03207581
6	Aplasia of the musculature (HP:0100854)	5.26486389
7	Weak cry (HP:0001612)	4.48061103
8	Fatigable weakness (HP:0003473)	4.29364670
9	Abnormality of the neuromuscular junction (HP:0003398)	4.29364670
10	Fetal akinesia sequence (HP:0001989)	4.22179937
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.98386785
12	Abnormality of alanine metabolism (HP:0010916)	3.98386785
13	Hyperalaninemia (HP:0003348)	3.98386785
14	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.93733766
15	Calf muscle hypertrophy (HP:0008981)	3.87797407
16	Distal arthrogryposis (HP:0005684)	3.55753581
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.54783816
18	Round ear (HP:0100830)	3.53550767
19	Muscle fiber inclusion bodies (HP:0100299)	3.52681491
20	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.50711573
21	Hyporeflexia of lower limbs (HP:0002600)	3.50004181
22	Muscle hypertrophy of the lower extremities (HP:0008968)	3.42273114
23	Absent phalangeal crease (HP:0006109)	3.32740975
24	Calcaneovalgus deformity (HP:0001848)	3.29384156
25	Gowers sign (HP:0003391)	3.25590358
26	Ulnar deviation of the wrist (HP:0003049)	3.19210369
27	Areflexia of lower limbs (HP:0002522)	3.17809587
28	Malignant hyperthermia (HP:0002047)	3.05851934
29	Abnormal finger flexion creases (HP:0006143)	3.04613619
30	Pterygium (HP:0001059)	3.04414280
31	Nemaline bodies (HP:0003798)	2.93445260
32	Septate vagina (HP:0001153)	2.93267441
33	Deformed tarsal bones (HP:0008119)	2.86783009
34	Hypoplastic heart (HP:0001961)	2.85359991
35	Hepatocellular necrosis (HP:0001404)	2.84268330
36	Mitochondrial inheritance (HP:0001427)	2.82790201
37	Hypoplasia of the uterus (HP:0000013)	2.81591226
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.81003801
39	Congenital, generalized hypertrichosis (HP:0004540)	2.79694709
40	Distal lower limb muscle weakness (HP:0009053)	2.77770926
41	Acute necrotizing encephalopathy (HP:0006965)	2.70841180
42	Cystic hygroma (HP:0000476)	2.70477774
43	Poor suck (HP:0002033)	2.70074095
44	Hypothermia (HP:0002045)	2.69580222
45	Dyschromatopsia (HP:0007641)	2.66753727
46	Hypoglycemic seizures (HP:0002173)	2.64050709
47	Easy fatigability (HP:0003388)	2.63146001
48	Aplasia/hypoplasia of the uterus (HP:0008684)	2.60360836
49	Abnormal mitochondria in muscle tissue (HP:0008316)	2.55801666
50	Akinesia (HP:0002304)	2.53118966
51	Increased CSF lactate (HP:0002490)	2.49579477
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.48908625
53	Muscle fiber splitting (HP:0003555)	2.47454066
54	Medial flaring of the eyebrow (HP:0010747)	2.46644107
55	Renal cortical cysts (HP:0000803)	2.44356971
56	Hepatic necrosis (HP:0002605)	2.42694245
57	Acute encephalopathy (HP:0006846)	2.42644896
58	Abnormality of the calf musculature (HP:0001430)	2.41691644
59	Pancreatic cysts (HP:0001737)	2.38819343
60	Congenital primary aphakia (HP:0007707)	2.33672529
61	Gait imbalance (HP:0002141)	2.28425062
62	Abnormality of the renal cortex (HP:0011035)	2.24036790
63	Progressive macrocephaly (HP:0004481)	2.21353620
64	Woolly hair (HP:0002224)	2.20839696
65	Increased hepatocellular lipid droplets (HP:0006565)	2.14316643
66	Disproportionate short-trunk short stature (HP:0003521)	2.13569991
67	Abnormality of the calcaneus (HP:0008364)	2.12598668
68	EMG: neuropathic changes (HP:0003445)	2.10996644
69	Renal Fanconi syndrome (HP:0001994)	2.06549454
70	Lipid accumulation in hepatocytes (HP:0006561)	2.06386590
71	Nonprogressive disorder (HP:0003680)	2.05661468
72	Asymmetric septal hypertrophy (HP:0001670)	2.03092655
73	Exercise-induced muscle cramps (HP:0003710)	2.02255773
74	Congenital stationary night blindness (HP:0007642)	2.02076416
75	Increased intramyocellular lipid droplets (HP:0012240)	2.01382462
76	Muscle stiffness (HP:0003552)	1.99878179
77	Unsteady gait (HP:0002317)	1.96953808
78	Tarsal synostosis (HP:0008368)	1.96903736
79	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.96884304
80	Pancreatic islet-cell hyperplasia (HP:0004510)	1.94837927
81	Nephrogenic diabetes insipidus (HP:0009806)	1.93333140
82	Ulnar deviation of the hand or of fingers of the hand (HP:0001193)	1.91600087
83	Abnormality of the left ventricular outflow tract (HP:0011103)	1.91003464
84	Subaortic stenosis (HP:0001682)	1.91003464
85	Chronic diarrhea (HP:0002028)	1.87804062
86	Synostosis involving bones of the feet (HP:0009140)	1.87105312
87	Synostosis involving bones of the lower limbs (HP:0009138)	1.87105312
88	Optic disc pallor (HP:0000543)	1.85861820
89	Increased serum lactate (HP:0002151)	1.84823554
90	Poor coordination (HP:0002370)	1.80957772
91	Vaginal atresia (HP:0000148)	1.80467617
92	Thin ribs (HP:0000883)	1.80150929
93	Bulbar palsy (HP:0001283)	1.79403894
94	Left ventricular hypertrophy (HP:0001712)	1.74506336
95	Colon cancer (HP:0003003)	1.73261480
96	Genital tract atresia (HP:0001827)	1.70964088
97	3-Methylglutaconic aciduria (HP:0003535)	1.69887881
98	Barrel-shaped chest (HP:0001552)	1.69243901
99	Bundle branch block (HP:0011710)	1.68076764
100	Webbed neck (HP:0000465)	1.67299882

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SCYL2	5.87702768
2	LIMK1	4.35508588
3	VRK2	4.29509765
4	TXK	4.24041928
5	NEK9	3.24937627
6	SRPK1	2.84019358
7	MAP3K12	2.77793989
8	MAP4K1	2.42170061
9	TESK1	2.41571952
10	ZAK	1.99218216
11	OBSCN	1.94111824
12	GRK1	1.93825576
13	TAF1	1.92196894
14	TLK1	1.87430400
15	BLK	1.82838760
16	NUAK1	1.73418031
17	STK16	1.70071827
18	ADRBK2	1.61957498
19	FRK	1.60679538
20	MAP3K13	1.52599826
21	CDK8	1.42863121
22	VRK1	1.42441073
23	TNK2	1.38390732
24	MAP3K9	1.25916234
25	WEE1	1.24001097
26	NLK	1.19556118
27	FLT3	1.15802052
28	STK38L	1.15636544
29	ERBB3	1.04786941
30	MAPKAPK3	1.02411735
31	STK3	1.01937731
32	BMPR1B	0.98756294
33	PDK2	0.98104569
34	WNK4	0.97892303
35	STK39	0.88802183
36	MYLK	0.88337863
37	SYK	0.85605599
38	CHEK2	0.84905885
39	PHKG2	0.82604469
40	PHKG1	0.82604469
41	TIE1	0.79392944
42	TAOK3	0.73990478
43	EIF2AK2	0.71892264
44	CSNK1G1	0.71273897
45	MAP4K2	0.70136856
46	DYRK1B	0.68851464
47	CSNK1A1L	0.68231639
48	LATS1	0.67910620
49	DAPK1	0.66151243
50	CSNK1G3	0.63734386
51	PRKCG	0.62682777
52	CCNB1	0.60909743
53	MAPKAPK5	0.60844382
54	DAPK2	0.60810129
55	INSRR	0.59984161
56	PRKG1	0.59890546
57	PIK3CG	0.57914987
58	DAPK3	0.56428112
59	BTK	0.55333691
60	IKBKB	0.54560679
61	CAMK2A	0.52964331
62	CDK19	0.52224798
63	MKNK2	0.51766831
64	CSNK1A1	0.51753448
65	PASK	0.51519574
66	TEC	0.50489419
67	BMPR2	0.49603435
68	BRAF	0.48948533
69	MOS	0.46073031
70	ARAF	0.45454892
71	IRAK1	0.45208600
72	CAMK1	0.44288046
73	CSNK1G2	0.43844334
74	LYN	0.40582268
75	MAPK15	0.40427357
76	NEK2	0.39861287
77	PRKACA	0.39185273
78	OXSR1	0.38350309
79	PRKAA2	0.38096500
80	EIF2AK3	0.34205175
81	MAPK13	0.33994415
82	CSNK2A1	0.32826611
83	FES	0.32698304
84	CDK3	0.32457927
85	CAMKK2	0.32225502
86	PRKCA	0.30806110
87	CSNK2A2	0.30572937
88	PKN1	0.29490030
89	PRKCD	0.29026259
90	CSNK1D	0.27563032
91	CLK1	0.26662932
92	RPS6KA6	0.26662720
93	DYRK2	0.26001799
94	CSF1R	0.25120633
95	NTRK3	0.25040395
96	WNK3	0.24937520
97	IGF1R	0.24647700
98	PLK3	0.24577045
99	GRK6	0.24458658
100	ITK	0.22607491

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.56085617
2	Ribosome_Homo sapiens_hsa03010	4.03477870
3	Parkinsons disease_Homo sapiens_hsa05012	3.65177571
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.44704689
5	Sulfur metabolism_Homo sapiens_hsa00920	3.26247361
6	Protein export_Homo sapiens_hsa03060	2.89772499
7	Alzheimers disease_Homo sapiens_hsa05010	2.60829071
8	Homologous recombination_Homo sapiens_hsa03440	2.53601828
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.37600024
10	Huntingtons disease_Homo sapiens_hsa05016	2.36275468
11	Mismatch repair_Homo sapiens_hsa03430	2.25083966
12	Base excision repair_Homo sapiens_hsa03410	2.13060933
13	Basal transcription factors_Homo sapiens_hsa03022	1.98000348
14	DNA replication_Homo sapiens_hsa03030	1.96096791
15	Nucleotide excision repair_Homo sapiens_hsa03420	1.92498853
16	Proteasome_Homo sapiens_hsa03050	1.89991121
17	RNA degradation_Homo sapiens_hsa03018	1.84193584
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.81213707
19	Caffeine metabolism_Homo sapiens_hsa00232	1.72695450
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.59439247
21	RNA polymerase_Homo sapiens_hsa03020	1.56455167
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.55431010
23	Phototransduction_Homo sapiens_hsa04744	1.52699119
24	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.46237352
25	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.44787740
26	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.39457708
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.30653158
28	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.25377803
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.25185485
30	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.21816169
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.21455527
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.18965400
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.18424323
34	Sulfur relay system_Homo sapiens_hsa04122	1.16971499
35	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.15141358
36	Propanoate metabolism_Homo sapiens_hsa00640	1.14681743
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.11846974
38	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.09499945
39	Linoleic acid metabolism_Homo sapiens_hsa00591	1.04984195
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99562572
41	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.94905431
42	Olfactory transduction_Homo sapiens_hsa04740	0.85080100
43	One carbon pool by folate_Homo sapiens_hsa00670	0.84972375
44	Primary immunodeficiency_Homo sapiens_hsa05340	0.82520069
45	Purine metabolism_Homo sapiens_hsa00230	0.81517831
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81439993
47	Asthma_Homo sapiens_hsa05310	0.80100877
48	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.78562299
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.77276478
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.76523994
51	Fanconi anemia pathway_Homo sapiens_hsa03460	0.75210632
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.72961581
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72408964
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.72136988
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70493433
56	Metabolic pathways_Homo sapiens_hsa01100	0.68374551
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.65332237
58	Spliceosome_Homo sapiens_hsa03040	0.63888486
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63820213
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.60585079
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.58739107
62	Regulation of autophagy_Homo sapiens_hsa04140	0.53425724
63	Nicotine addiction_Homo sapiens_hsa05033	0.52182335
64	Tryptophan metabolism_Homo sapiens_hsa00380	0.51680225
65	Allograft rejection_Homo sapiens_hsa05330	0.50794412
66	Circadian rhythm_Homo sapiens_hsa04710	0.50167288
67	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.48672435
68	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44060023
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43862382
70	Viral myocarditis_Homo sapiens_hsa05416	0.42204431
71	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.39657846
72	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.38969429
73	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38814126
74	Peroxisome_Homo sapiens_hsa04146	0.38325879
75	p53 signaling pathway_Homo sapiens_hsa04115	0.38135808
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36393950
77	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.35304046
78	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.34590382
79	Insulin secretion_Homo sapiens_hsa04911	0.34205815
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.33363135
81	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.33090978
82	RNA transport_Homo sapiens_hsa03013	0.32866952
83	Retinol metabolism_Homo sapiens_hsa00830	0.32534901
84	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31859826
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.31636763
86	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.31381844
87	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.29291501
88	Mineral absorption_Homo sapiens_hsa04978	0.27840611
89	Taste transduction_Homo sapiens_hsa04742	0.27829603
90	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.27132458
91	Morphine addiction_Homo sapiens_hsa05032	0.25907746
92	ABC transporters_Homo sapiens_hsa02010	0.23663422
93	Salivary secretion_Homo sapiens_hsa04970	0.22230291
94	Antigen processing and presentation_Homo sapiens_hsa04612	0.22075766
95	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.18019312
96	Rheumatoid arthritis_Homo sapiens_hsa05323	0.17823055
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.16735390
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.16260431
99	Renin-angiotensin system_Homo sapiens_hsa04614	0.14076121
100	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.13872526

RPL21P133

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »