RPL21P134

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.99819179
2cytidine metabolic process (GO:0046087)6.49402718
3cytidine catabolic process (GO:0006216)6.49402718
4cytidine deamination (GO:0009972)6.49402718
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.78440490
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.59659845
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.45947760
8ribosomal small subunit assembly (GO:0000028)4.13129462
9Arp2/3 complex-mediated actin nucleation (GO:0034314)4.11003850
10ATP synthesis coupled proton transport (GO:0015986)4.02243205
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.02243205
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.95114238
13actin nucleation (GO:0045010)3.86826426
14respiratory electron transport chain (GO:0022904)3.64392524
15electron transport chain (GO:0022900)3.61756104
16protein complex biogenesis (GO:0070271)3.50062804
17platelet dense granule organization (GO:0060155)3.45861227
18positive thymic T cell selection (GO:0045059)3.31882240
19negative regulation by host of viral transcription (GO:0043922)3.30587968
20positive T cell selection (GO:0043368)3.30114320
21protein neddylation (GO:0045116)3.26713024
22cytochrome complex assembly (GO:0017004)3.26524729
23mannosylation (GO:0097502)3.26016214
24negative regulation of T cell apoptotic process (GO:0070233)3.22983674
25negative T cell selection (GO:0043383)3.19398729
26respiratory chain complex IV assembly (GO:0008535)3.17746270
27positive regulation of B cell differentiation (GO:0045579)3.16183016
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.11800710
29response to pheromone (GO:0019236)3.11699578
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.11242400
31pyrimidine nucleoside catabolic process (GO:0046135)3.06415205
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04558841
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04558841
34mitochondrial respiratory chain complex assembly (GO:0033108)3.03717156
35regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01283040
36GPI anchor biosynthetic process (GO:0006506)2.99571632
37response to interferon-beta (GO:0035456)2.99486286
38GPI anchor metabolic process (GO:0006505)2.98819026
39positive regulation of interleukin-8 secretion (GO:2000484)2.95923681
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95586435
41sequestering of actin monomers (GO:0042989)2.94429742
42positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.89188065
43positive regulation of calcium-mediated signaling (GO:0050850)2.88356464
44positive regulation of natural killer cell mediated immunity (GO:0002717)2.87720469
45regulation of activation of Janus kinase activity (GO:0010533)2.86522587
46proteasome assembly (GO:0043248)2.85814826
47positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.84614137
48positive regulation of T cell mediated cytotoxicity (GO:0001916)2.83840373
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81138618
50mitochondrial respiratory chain complex I assembly (GO:0032981)2.81138618
51NADH dehydrogenase complex assembly (GO:0010257)2.81138618
52regulation of T cell receptor signaling pathway (GO:0050856)2.80363019
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.80170284
54regulation of regulatory T cell differentiation (GO:0045589)2.77615760
55regulation of B cell receptor signaling pathway (GO:0050855)2.76482348
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75924356
57mast cell activation (GO:0045576)2.75880031
58DNA dealkylation (GO:0035510)2.71080913
59positive regulation of defense response to virus by host (GO:0002230)2.70643386
60aggressive behavior (GO:0002118)2.69703026
61establishment of protein localization to mitochondrial membrane (GO:0090151)2.69622929
62DNA demethylation (GO:0080111)2.68463640
63hydrogen ion transmembrane transport (GO:1902600)2.68294854
64cellular ketone body metabolic process (GO:0046950)2.67651809
65regulation of interleukin-8 secretion (GO:2000482)2.65867387
66regulation of cellular amino acid metabolic process (GO:0006521)2.64730230
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.64442081
68negative regulation of viral genome replication (GO:0045071)2.63434910
69T cell migration (GO:0072678)2.62121963
70preassembly of GPI anchor in ER membrane (GO:0016254)2.61257681
71regulation of T cell mediated cytotoxicity (GO:0001914)2.60994901
72negative thymic T cell selection (GO:0045060)2.59817836
73regulation of B cell differentiation (GO:0045577)2.59196519
74positive regulation of alpha-beta T cell proliferation (GO:0046641)2.58282493
75eosinophil chemotaxis (GO:0048245)2.58164862
76proton transport (GO:0015992)2.57914324
77regulation of leukocyte mediated cytotoxicity (GO:0001910)2.57763041
78base-excision repair, AP site formation (GO:0006285)2.55129608
79iron-sulfur cluster assembly (GO:0016226)2.55032656
80metallo-sulfur cluster assembly (GO:0031163)2.55032656
81regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.53964730
82hydrogen transport (GO:0006818)2.53415329
83deoxyribonucleotide catabolic process (GO:0009264)2.52569379
84negative regulation of lymphocyte apoptotic process (GO:0070229)2.51280407
85negative regulation of mast cell activation (GO:0033004)2.50816542
86pseudouridine synthesis (GO:0001522)2.50002412
87deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.48392876
88purine deoxyribonucleotide catabolic process (GO:0009155)2.47754168
89positive regulation of cell killing (GO:0031343)2.46368266
90immunoglobulin mediated immune response (GO:0016064)2.46342290
91cellular response to interleukin-15 (GO:0071350)2.46066330
92axoneme assembly (GO:0035082)2.45756216
93regulation of alpha-beta T cell proliferation (GO:0046640)2.45172812
94ketone body metabolic process (GO:1902224)2.44327139
95water-soluble vitamin biosynthetic process (GO:0042364)2.44306539
96regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.43665863
97regulation of natural killer cell mediated immunity (GO:0002715)2.43665863
98cytolysis (GO:0019835)2.43233236
99SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.42723242
100T cell receptor signaling pathway (GO:0050852)2.40343780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.31194651
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.39205396
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.87612147
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.78473195
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77901948
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.76898738
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58742191
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58688258
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53555872
10IGF1R_20145208_ChIP-Seq_DFB_Human2.48751523
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45189630
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.39960947
13VDR_22108803_ChIP-Seq_LS180_Human2.39086291
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37405615
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37337800
16ZNF274_21170338_ChIP-Seq_K562_Hela2.32822734
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.30856015
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24188700
19VDR_23849224_ChIP-Seq_CD4+_Human2.13161206
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.07727322
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.89522535
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83944861
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78735026
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77654327
25EZH2_22144423_ChIP-Seq_EOC_Human1.76155118
26MYB_26560356_Chip-Seq_TH2_Human1.72019014
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63738852
28ELK1_19687146_ChIP-ChIP_HELA_Human1.61249910
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.60571940
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57227096
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55941384
32FOXP3_21729870_ChIP-Seq_TREG_Human1.55731987
33GATA3_26560356_Chip-Seq_TH2_Human1.53911007
34TP53_22573176_ChIP-Seq_HFKS_Human1.52917533
35MYC_18940864_ChIP-ChIP_HL60_Human1.50787054
36EWS_26573619_Chip-Seq_HEK293_Human1.48768907
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48462237
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47790341
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.47665163
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.45420569
41AR_20517297_ChIP-Seq_VCAP_Human1.44644925
42GATA3_27048872_Chip-Seq_THYMUS_Human1.44395240
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43513488
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42959865
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.42959865
46ER_23166858_ChIP-Seq_MCF-7_Human1.41243883
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33668800
48FUS_26573619_Chip-Seq_HEK293_Human1.29944985
49RUNX_20019798_ChIP-Seq_JUKART_Human1.29807211
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28577015
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28445068
52TAF15_26573619_Chip-Seq_HEK293_Human1.28388816
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.28001266
54PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27809379
55P300_19829295_ChIP-Seq_ESCs_Human1.27464995
56FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26921456
57NANOG_19829295_ChIP-Seq_ESCs_Human1.25995360
58SOX2_19829295_ChIP-Seq_ESCs_Human1.25995360
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24928014
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24431629
61CBP_20019798_ChIP-Seq_JUKART_Human1.23501751
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23501751
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23146203
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21990165
65NCOR_22424771_ChIP-Seq_293T_Human1.21135407
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16901202
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16310252
68NANOG_20526341_ChIP-Seq_ESCs_Human1.15124981
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.14852353
70ERG_20517297_ChIP-Seq_VCAP_Human1.14783882
71PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.14780642
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.14361736
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13256006
74HTT_18923047_ChIP-ChIP_STHdh_Human1.12995686
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12956528
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12248107
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11296894
78TAF2_19829295_ChIP-Seq_ESCs_Human1.10722898
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09368435
80GBX2_23144817_ChIP-Seq_PC3_Human1.05624708
81MYC_19829295_ChIP-Seq_ESCs_Human1.04906879
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02855076
83BCAT_22108803_ChIP-Seq_LS180_Human1.02444872
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.02336409
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01525921
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00952383
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00634616
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96772590
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95748552
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.94974982
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94812779
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93027783
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91534793
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91163859
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90468402
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90166035
97P300_27268052_Chip-Seq_Bcells_Human0.90016512
98RBPJ_21746931_ChIP-Seq_IB4_Human0.89969596
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.89928624
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89436686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.42683183
2MP0001835_abnormal_antigen_presentation2.85238798
3MP0009379_abnormal_foot_pigmentation2.52063874
4MP0009785_altered_susceptibility_to2.51136176
5MP0000372_irregular_coat_pigmentation2.35083710
6MP0005645_abnormal_hypothalamus_physiol2.32879512
7MP0006072_abnormal_retinal_apoptosis2.28681473
8MP0005646_abnormal_pituitary_gland2.11832124
9MP0002102_abnormal_ear_morphology2.07724116
10MP0005000_abnormal_immune_tolerance2.01038754
11MP0001800_abnormal_humoral_immune1.96580112
12MP0002148_abnormal_hypersensitivity_rea1.92626176
13MP0004147_increased_porphyrin_level1.91697071
14MP0006292_abnormal_olfactory_placode1.86642564
15MP0005551_abnormal_eye_electrophysiolog1.86229986
16MP0005075_abnormal_melanosome_morpholog1.80687972
17MP0009333_abnormal_splenocyte_physiolog1.79514590
18MP0003763_abnormal_thymus_physiology1.78713890
19MP0008877_abnormal_DNA_methylation1.76314044
20MP0008872_abnormal_physiological_respon1.75751840
21MP0002723_abnormal_immune_serum1.68540986
22MP0001873_stomach_inflammation1.66969890
23MP0005025_abnormal_response_to1.66438631
24MP0002420_abnormal_adaptive_immunity1.64589781
25MP0003646_muscle_fatigue1.64116335
26MP0005084_abnormal_gallbladder_morpholo1.63162700
27MP0002166_altered_tumor_susceptibility1.63041099
28MP0005253_abnormal_eye_physiology1.63001691
29MP0002163_abnormal_gland_morphology1.61744210
30MP0001819_abnormal_immune_cell1.59239900
31MP0002837_dystrophic_cardiac_calcinosis1.58577851
32MP0003011_delayed_dark_adaptation1.58075793
33MP0003195_calcinosis1.55252068
34MP0008875_abnormal_xenobiotic_pharmacok1.53691063
35MP0002452_abnormal_antigen_presenting1.47102002
36MP0001905_abnormal_dopamine_level1.46055649
37MP0003880_abnormal_central_pattern1.42842575
38MP0001790_abnormal_immune_system1.42183430
39MP0005387_immune_system_phenotype1.42183430
40MP0008995_early_reproductive_senescence1.42162730
41MP0003787_abnormal_imprinting1.40429323
42MP0001764_abnormal_homeostasis1.40372211
43MP0005389_reproductive_system_phenotype1.37814107
44MP0006082_CNS_inflammation1.35956325
45MP0003866_abnormal_defecation1.35821803
46MP0001919_abnormal_reproductive_system1.34754261
47MP0000685_abnormal_immune_system1.32424835
48MP0003806_abnormal_nucleotide_metabolis1.32223358
49MP0002006_tumorigenesis1.30423844
50MP0000716_abnormal_immune_system1.29231689
51MP0010386_abnormal_urinary_bladder1.28721298
52MP0005379_endocrine/exocrine_gland_phen1.27643553
53MP0001968_abnormal_touch/_nociception1.27060398
54MP0002277_abnormal_respiratory_mucosa1.26403006
55MP0002398_abnormal_bone_marrow1.24930017
56MP0002876_abnormal_thyroid_physiology1.24234264
57MP0004145_abnormal_muscle_electrophysio1.21016412
58MP0002095_abnormal_skin_pigmentation1.20852436
59MP0006036_abnormal_mitochondrial_physio1.19845101
60MP0005410_abnormal_fertilization1.16564375
61MP0000689_abnormal_spleen_morphology1.15874074
62MP0003786_premature_aging1.13853471
63MP0006276_abnormal_autonomic_nervous1.11634072
64MP0001986_abnormal_taste_sensitivity1.09521843
65MP0002638_abnormal_pupillary_reflex1.08595839
66MP0001485_abnormal_pinna_reflex1.08388643
67MP0002405_respiratory_system_inflammati1.07081713
68MP0009764_decreased_sensitivity_to1.05727327
69MP0001845_abnormal_inflammatory_respons1.05250263
70MP0002736_abnormal_nociception_after1.04906680
71MP0005174_abnormal_tail_pigmentation1.04523465
72MP0002693_abnormal_pancreas_physiology1.03668028
73MP0005636_abnormal_mineral_homeostasis1.02196623
74MP0004142_abnormal_muscle_tone0.99397183
75MP0002722_abnormal_immune_system0.97548287
76MP0010155_abnormal_intestine_physiology0.96807433
77MP0003724_increased_susceptibility_to0.96243871
78MP0008469_abnormal_protein_level0.95150581
79MP0004885_abnormal_endolymph0.94956720
80MP0002234_abnormal_pharynx_morphology0.94489434
81MP0002160_abnormal_reproductive_system0.93834921
82MP0002429_abnormal_blood_cell0.93707741
83MP0001765_abnormal_ion_homeostasis0.88411147
84MP0002419_abnormal_innate_immunity0.87199818
85MP0002138_abnormal_hepatobiliary_system0.86079643
86MP0002933_joint_inflammation0.85834616
87MP0008058_abnormal_DNA_repair0.85647745
88MP0001501_abnormal_sleep_pattern0.84002196
89MP0005464_abnormal_platelet_physiology0.82478857
90MP0000703_abnormal_thymus_morphology0.80676311
91MP0004043_abnormal_pH_regulation0.79759856
92MP0009745_abnormal_behavioral_response0.79527507
93MP0000631_abnormal_neuroendocrine_gland0.77933069
94MP0003252_abnormal_bile_duct0.75217978
95MP0008789_abnormal_olfactory_epithelium0.74697071
96MP0001984_abnormal_olfaction0.74348278
97MP0005085_abnormal_gallbladder_physiolo0.73590632
98MP0003137_abnormal_impulse_conducting0.71716773
99MP0000639_abnormal_adrenal_gland0.71174918
100MP0005332_abnormal_amino_acid0.70979613

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.16474066
2Mitochondrial inheritance (HP:0001427)3.94187350
3Severe combined immunodeficiency (HP:0004430)3.82170142
4Congenital stationary night blindness (HP:0007642)3.78080922
5IgG deficiency (HP:0004315)3.70593820
6Acute necrotizing encephalopathy (HP:0006965)3.68273574
7Hepatocellular necrosis (HP:0001404)3.63635428
8Abnormality of B cell number (HP:0010975)3.48079254
9Abnormal mitochondria in muscle tissue (HP:0008316)3.42138937
10Hypoproteinemia (HP:0003075)3.40122691
11Increased CSF lactate (HP:0002490)3.38767603
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.33665099
13Thyroiditis (HP:0100646)3.32173518
14Elevated erythrocyte sedimentation rate (HP:0003565)3.28243444
15Hepatic necrosis (HP:0002605)3.27809886
16Renal Fanconi syndrome (HP:0001994)3.26158708
173-Methylglutaconic aciduria (HP:0003535)3.23225726
18B lymphocytopenia (HP:0010976)3.20741335
19T lymphocytopenia (HP:0005403)3.19398705
20Abnormality of T cell number (HP:0011839)3.17762228
21Increased hepatocellular lipid droplets (HP:0006565)3.12061627
22Acute encephalopathy (HP:0006846)3.10492955
23Progressive macrocephaly (HP:0004481)3.10424787
24Increased intramyocellular lipid droplets (HP:0012240)3.03324698
25Lipid accumulation in hepatocytes (HP:0006561)2.95517146
26Stomatitis (HP:0010280)2.92684116
27Abnormal rod and cone electroretinograms (HP:0008323)2.89936020
28Combined immunodeficiency (HP:0005387)2.84305305
29Pancreatic cysts (HP:0001737)2.79572796
30Attenuation of retinal blood vessels (HP:0007843)2.78024174
31Autoimmune hemolytic anemia (HP:0001890)2.77471964
32Abolished electroretinogram (ERG) (HP:0000550)2.65939123
33Increased muscle lipid content (HP:0009058)2.62399113
34Abnormality of T cells (HP:0002843)2.60597902
35Molar tooth sign on MRI (HP:0002419)2.54177913
36Abnormality of midbrain morphology (HP:0002418)2.54177913
37Increased IgM level (HP:0003496)2.53364632
38Abnormality of eosinophils (HP:0001879)2.51717033
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.50890375
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.50890375
41Decreased central vision (HP:0007663)2.47283665
42Optic disc pallor (HP:0000543)2.46993643
43Abnormality of the prostate (HP:0008775)2.46883804
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.46728137
45Cerebral edema (HP:0002181)2.46098732
46Renal cortical cysts (HP:0000803)2.42890275
47True hermaphroditism (HP:0010459)2.42404118
48Pancreatic fibrosis (HP:0100732)2.30660810
49Agammaglobulinemia (HP:0004432)2.30396927
50Exertional dyspnea (HP:0002875)2.29659688
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28230634
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.25276429
53Methylmalonic acidemia (HP:0002912)2.24749097
54Panhypogammaglobulinemia (HP:0003139)2.23907902
55Generalized aminoaciduria (HP:0002909)2.23556164
56Constricted visual fields (HP:0001133)2.22628962
57Abnormal number of erythroid precursors (HP:0012131)2.17376396
58Medial flaring of the eyebrow (HP:0010747)2.16375808
59Lactic acidosis (HP:0003128)2.12985983
60Chronic diarrhea (HP:0002028)2.12471872
61Increased serum lactate (HP:0002151)2.10726144
62Lethargy (HP:0001254)2.10581429
63Eosinophilia (HP:0001880)2.09266180
64Abnormality of the renal cortex (HP:0011035)2.09069783
65Dicarboxylic aciduria (HP:0003215)2.07527679
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07527679
67Abnormality of cells of the erythroid lineage (HP:0012130)2.06180391
68Ketosis (HP:0001946)2.05480120
69Abnormality of renal resorption (HP:0011038)2.03119615
70Hypothermia (HP:0002045)2.02524167
71Methylmalonic aciduria (HP:0012120)1.99342826
72Ketoacidosis (HP:0001993)1.98926190
73Type I transferrin isoform profile (HP:0003642)1.96858099
74Pancytopenia (HP:0001876)1.96729999
75Abnormal delayed hypersensitivity skin test (HP:0002963)1.96702313
76Respiratory failure (HP:0002878)1.94612054
77Nephronophthisis (HP:0000090)1.94395811
78Hypoalbuminemia (HP:0003073)1.93868779
79Abnormal albumin level (HP:0012116)1.93868779
80Glycosuria (HP:0003076)1.91434986
81Abnormality of urine glucose concentration (HP:0011016)1.91434986
82Hyperglycinemia (HP:0002154)1.87181885
83Encephalitis (HP:0002383)1.86264290
84Reticulocytopenia (HP:0001896)1.82326587
85Leukocytosis (HP:0001974)1.81619105
86Abnormality of T cell physiology (HP:0011840)1.80875512
87Recurrent bronchitis (HP:0002837)1.79063522
88Congenital, generalized hypertrichosis (HP:0004540)1.78018960
89Oral leukoplakia (HP:0002745)1.77579880
90Type 2 muscle fiber atrophy (HP:0003554)1.77383128
91Abnormal protein glycosylation (HP:0012346)1.75657389
92Abnormal glycosylation (HP:0012345)1.75657389
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75657389
94Abnormal protein N-linked glycosylation (HP:0012347)1.75657389
95Exercise intolerance (HP:0003546)1.74744945
96Hypoplasia of the thymus (HP:0000778)1.74446886
97Chronic sinusitis (HP:0011109)1.73491758
98Meningitis (HP:0001287)1.73436848
99Autoimmune thrombocytopenia (HP:0001973)1.72800635
100Neutropenia (HP:0001875)1.71565120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.46305680
2KDR4.21308401
3TESK23.33315489
4MAP4K23.05202005
5TAOK33.04052520
6BCKDK2.80586051
7GRK12.43658655
8VRK22.40605643
9ADRBK22.37389834
10FRK2.30299274
11CDK192.29316583
12ZAK2.08905823
13SCYL22.08124977
14MAP4K12.02932786
15NUAK11.94134156
16MAP3K121.87564223
17ITK1.66629520
18KIT1.58149005
19VRK11.56021885
20TLK11.54611967
21PINK11.49933953
22MST41.41338306
23TNK21.38362867
24FES1.33814595
25TEC1.31879133
26SYK1.29381905
27LIMK11.28237986
28GRK61.19109234
29BMPR21.18799772
30BMPR1B1.17906775
31TIE11.14830900
32WNK31.10428306
33MUSK1.09846124
34PASK1.09060466
35DAPK21.07012883
36FLT31.00072665
37TESK10.99897192
38INSRR0.99196451
39IKBKB0.95270984
40LCK0.94925845
41PRKCQ0.93786282
42BTK0.90687735
43TRPM70.90399616
44OXSR10.89941884
45CSF1R0.89556088
46MAP3K110.87899391
47MYLK0.85100737
48DAPK10.84250021
49LYN0.83880514
50IKBKE0.81372766
51ZAP700.79563908
52MAPK130.77477470
53WNK40.75526845
54ERBB30.73679971
55OBSCN0.71869325
56STK160.71746967
57PIM20.70659536
58MAP2K60.69923255
59RPS6KA50.69689012
60PIK3CG0.69236057
61TBK10.67964395
62MAP2K70.67076799
63CSNK1G30.66669554
64CAMKK20.65373549
65EIF2AK30.62572412
66GRK70.62063732
67ADRBK10.60439018
68NME10.58853110
69PIM10.56782151
70JAK30.55755389
71DYRK20.54662208
72RPS6KA40.54648437
73CDK80.54467278
74IGF1R0.54280885
75MATK0.52203417
76PLK40.49426222
77CSNK1G10.49053309
78DAPK30.47769945
79MAP3K40.46607960
80CSK0.46107612
81PRKACA0.45097079
82PRKCA0.44211511
83PRKCE0.43202470
84CSNK1G20.42455142
85STK38L0.40342283
86ROCK10.38769658
87CAMK2A0.38558458
88MAPK150.38402626
89MAPKAPK30.36519910
90CSNK1A1L0.35896115
91PIK3CA0.33154524
92CSNK1A10.32563513
93TRIM280.32562231
94BCR0.31763058
95MAP3K50.30944778
96CSNK2A10.30781489
97PKN10.30556551
98CAMK10.30286125
99CSNK2A20.28267524
100HCK0.27739325

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.05707741
2Oxidative phosphorylation_Homo sapiens_hsa001903.60785161
3Proteasome_Homo sapiens_hsa030503.30477678
4Parkinsons disease_Homo sapiens_hsa050122.88461254
5Allograft rejection_Homo sapiens_hsa053302.84539063
6Autoimmune thyroid disease_Homo sapiens_hsa053202.80994254
7Graft-versus-host disease_Homo sapiens_hsa053322.69073454
8Ribosome_Homo sapiens_hsa030102.69006973
9Asthma_Homo sapiens_hsa053102.49297635
10Type I diabetes mellitus_Homo sapiens_hsa049402.47536455
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.24994358
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22127701
13Antigen processing and presentation_Homo sapiens_hsa046122.17639645
14Protein export_Homo sapiens_hsa030602.17394149
15Alzheimers disease_Homo sapiens_hsa050101.93411830
16Phototransduction_Homo sapiens_hsa047441.89715530
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88779552
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88549881
19Hematopoietic cell lineage_Homo sapiens_hsa046401.78372129
20RNA polymerase_Homo sapiens_hsa030201.76044466
21Huntingtons disease_Homo sapiens_hsa050161.68756812
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66998269
23Rheumatoid arthritis_Homo sapiens_hsa053231.59526198
24Cardiac muscle contraction_Homo sapiens_hsa042601.50904390
25Linoleic acid metabolism_Homo sapiens_hsa005911.48694833
26Homologous recombination_Homo sapiens_hsa034401.42101550
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.25993561
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24859758
29Butanoate metabolism_Homo sapiens_hsa006501.23600590
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23583542
31Peroxisome_Homo sapiens_hsa041461.10452934
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09163499
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09142027
34Nitrogen metabolism_Homo sapiens_hsa009101.06121980
35RNA degradation_Homo sapiens_hsa030181.06034221
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03477694
37Caffeine metabolism_Homo sapiens_hsa002320.99695155
38Olfactory transduction_Homo sapiens_hsa047400.98641693
39Viral myocarditis_Homo sapiens_hsa054160.97810067
40Steroid hormone biosynthesis_Homo sapiens_hsa001400.96238369
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95611373
42Chemical carcinogenesis_Homo sapiens_hsa052040.94234853
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93041167
44Propanoate metabolism_Homo sapiens_hsa006400.92743903
45Arachidonic acid metabolism_Homo sapiens_hsa005900.90298048
46Fanconi anemia pathway_Homo sapiens_hsa034600.89665110
47Retinol metabolism_Homo sapiens_hsa008300.86928916
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86857347
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86755953
50T cell receptor signaling pathway_Homo sapiens_hsa046600.86644901
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85277026
52Pyrimidine metabolism_Homo sapiens_hsa002400.78528707
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77239095
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75851251
55Tryptophan metabolism_Homo sapiens_hsa003800.75276985
56Collecting duct acid secretion_Homo sapiens_hsa049660.74383732
57Ether lipid metabolism_Homo sapiens_hsa005650.73963915
58One carbon pool by folate_Homo sapiens_hsa006700.71891857
59Purine metabolism_Homo sapiens_hsa002300.71569161
60Nucleotide excision repair_Homo sapiens_hsa034200.69821670
61Systemic lupus erythematosus_Homo sapiens_hsa053220.67106730
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66777165
63Staphylococcus aureus infection_Homo sapiens_hsa051500.66719314
64Basal transcription factors_Homo sapiens_hsa030220.61683374
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61235618
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59267755
67Sulfur metabolism_Homo sapiens_hsa009200.58375846
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.57754194
69Metabolic pathways_Homo sapiens_hsa011000.55099610
70Taste transduction_Homo sapiens_hsa047420.54075675
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52014090
72Fatty acid elongation_Homo sapiens_hsa000620.50090164
73Regulation of autophagy_Homo sapiens_hsa041400.49733091
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.49048615
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47966751
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47803783
77Nicotine addiction_Homo sapiens_hsa050330.46404434
78Base excision repair_Homo sapiens_hsa034100.43606339
79Measles_Homo sapiens_hsa051620.43379282
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.42832252
81Malaria_Homo sapiens_hsa051440.41968811
82Mismatch repair_Homo sapiens_hsa034300.41703301
83Glutathione metabolism_Homo sapiens_hsa004800.39661592
84Non-homologous end-joining_Homo sapiens_hsa034500.37098307
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36483061
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35875661
87ABC transporters_Homo sapiens_hsa020100.33629649
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33616067
89Fat digestion and absorption_Homo sapiens_hsa049750.33586725
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33458743
91Salivary secretion_Homo sapiens_hsa049700.33046870
92Selenocompound metabolism_Homo sapiens_hsa004500.31774368
93Herpes simplex infection_Homo sapiens_hsa051680.30165976
94African trypanosomiasis_Homo sapiens_hsa051430.30124965
95Leishmaniasis_Homo sapiens_hsa051400.29313436
96DNA replication_Homo sapiens_hsa030300.28863165
97Salmonella infection_Homo sapiens_hsa051320.26664948
98RNA transport_Homo sapiens_hsa030130.26589711
99Spliceosome_Homo sapiens_hsa030400.24248521
100Fatty acid degradation_Homo sapiens_hsa000710.22602109

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