ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.60837153
2	DNA deamination (GO:0045006)	4.72660471
3	indole-containing compound catabolic process (GO:0042436)	4.26583060
4	indolalkylamine catabolic process (GO:0046218)	4.26583060
5	tryptophan catabolic process (GO:0006569)	4.26583060
6	L-fucose catabolic process (GO:0042355)	4.14712082
7	fucose catabolic process (GO:0019317)	4.14712082
8	L-fucose metabolic process (GO:0042354)	4.14712082
9	platelet dense granule organization (GO:0060155)	4.03359150
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.92052923
11	indolalkylamine metabolic process (GO:0006586)	3.91860473
12	response to pheromone (GO:0019236)	3.90963733
13	kynurenine metabolic process (GO:0070189)	3.84001914
14	tryptophan metabolic process (GO:0006568)	3.68163806
15	protein complex biogenesis (GO:0070271)	3.53903507
16	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.36334033
17	axoneme assembly (GO:0035082)	3.32469151
18	respiratory chain complex IV assembly (GO:0008535)	3.22960439
19	negative regulation of telomere maintenance (GO:0032205)	3.22319286
20	piRNA metabolic process (GO:0034587)	3.21698267
21	mitochondrial respiratory chain complex assembly (GO:0033108)	3.21010938
22	amine catabolic process (GO:0009310)	3.19591247
23	cellular biogenic amine catabolic process (GO:0042402)	3.19591247
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.19001980
25	NADH dehydrogenase complex assembly (GO:0010257)	3.19001980
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.19001980
27	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.17132735
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.17132735
29	protein neddylation (GO:0045116)	3.14741527
30	cytidine deamination (GO:0009972)	3.14243636
31	cytidine metabolic process (GO:0046087)	3.14243636
32	cytidine catabolic process (GO:0006216)	3.14243636
33	detection of light stimulus involved in sensory perception (GO:0050962)	3.14202194
34	detection of light stimulus involved in visual perception (GO:0050908)	3.14202194
35	cellular ketone body metabolic process (GO:0046950)	3.11812982
36	negative regulation of mast cell activation (GO:0033004)	3.11037524
37	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.08462190
38	cytochrome complex assembly (GO:0017004)	3.07491883
39	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.03903422
40	indole-containing compound metabolic process (GO:0042430)	3.01232256
41	mannosylation (GO:0097502)	2.98337913
42	epithelial cilium movement (GO:0003351)	2.96449295
43	preassembly of GPI anchor in ER membrane (GO:0016254)	2.93603823
44	gamma-aminobutyric acid transport (GO:0015812)	2.92775570
45	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.87901355
46	dopamine transport (GO:0015872)	2.87900376
47	ketone body metabolic process (GO:1902224)	2.86807984
48	cornea development in camera-type eye (GO:0061303)	2.86780027
49	behavioral response to ethanol (GO:0048149)	2.79722724
50	protein polyglutamylation (GO:0018095)	2.79419954
51	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.76153168
52	kidney morphogenesis (GO:0060993)	2.76129877
53	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.75831131
54	neural tube formation (GO:0001841)	2.71480512
55	positive regulation of defense response to virus by host (GO:0002230)	2.71268872
56	parturition (GO:0007567)	2.63173880
57	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.62544638
58	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.60277702
59	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.59865825
60	ATP synthesis coupled proton transport (GO:0015986)	2.59865825
61	peptidyl-histidine modification (GO:0018202)	2.59489099
62	retinal cone cell development (GO:0046549)	2.57772333
63	DNA methylation involved in gamete generation (GO:0043046)	2.57402968
64	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.57264253
65	synaptic transmission, cholinergic (GO:0007271)	2.57184272
66	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.56261185
67	protein localization to cilium (GO:0061512)	2.54514781
68	ubiquinone biosynthetic process (GO:0006744)	2.53905894
69	primary amino compound metabolic process (GO:1901160)	2.53886233
70	benzene-containing compound metabolic process (GO:0042537)	2.53474702
71	sulfation (GO:0051923)	2.51709348
72	regulation of action potential (GO:0098900)	2.51092623
73	aromatic amino acid family catabolic process (GO:0009074)	2.50830161
74	regulation of memory T cell differentiation (GO:0043380)	2.50772141
75	positive regulation of fatty acid transport (GO:2000193)	2.50745235
76	rhodopsin mediated signaling pathway (GO:0016056)	2.49757084
77	reciprocal meiotic recombination (GO:0007131)	2.49343794
78	reciprocal DNA recombination (GO:0035825)	2.49343794
79	regulation of neurotransmitter uptake (GO:0051580)	2.48550074
80	adenosine metabolic process (GO:0046085)	2.48291802
81	adaptation of signaling pathway (GO:0023058)	2.47336229
82	transmission of nerve impulse (GO:0019226)	2.46640609
83	nephron epithelium morphogenesis (GO:0072088)	2.42361776
84	nephron tubule morphogenesis (GO:0072078)	2.42361776
85	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.41332297
86	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.41153336
87	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.40794666
88	neuronal action potential (GO:0019228)	2.39735701
89	endoderm formation (GO:0001706)	2.39657985
90	GPI anchor metabolic process (GO:0006505)	2.37906714
91	photoreceptor cell development (GO:0042461)	2.37669449
92	S-adenosylmethionine metabolic process (GO:0046500)	2.35682621
93	cilium movement (GO:0003341)	2.35254134
94	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.34506195
95	multicellular organism reproduction (GO:0032504)	2.34104085
96	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.33643786
97	somite development (GO:0061053)	2.33174694
98	nonmotile primary cilium assembly (GO:0035058)	2.33093371
99	cilium morphogenesis (GO:0060271)	2.32357358
100	ubiquinone metabolic process (GO:0006743)	2.32111335

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.66388827
2	VDR_22108803_ChIP-Seq_LS180_Human	3.42326860
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.71484011
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.55165550
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.51826817
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.51015241
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.43402705
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.34786019
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.27405940
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.14191094
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.13938944
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.08730189
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05772812
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.97530253
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96748483
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.94215036
17	EWS_26573619_Chip-Seq_HEK293_Human	1.94214876
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.92046542
19	P300_19829295_ChIP-Seq_ESCs_Human	1.91322624
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.88760162
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.87499951
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80373746
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.67597040
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.63056472
25	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.61661451
26	FUS_26573619_Chip-Seq_HEK293_Human	1.61587150
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.61322033
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.61080207
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58527080
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56653446
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.53702323
32	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.51288477
33	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.51288477
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50032055
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49836909
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.47976087
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47843681
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47328122
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.47328122
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.46827095
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.46827095
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.43343987
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.43196623
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41952181
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40213851
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39863292
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.37373850
48	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.34276294
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.34205956
50	AR_25329375_ChIP-Seq_VCAP_Human	1.32259503
51	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.31195209
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30467544
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29739679
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28868817
55	AR_20517297_ChIP-Seq_VCAP_Human	1.28188248
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28089662
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.27056587
58	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.26524281
59	NCOR_22424771_ChIP-Seq_293T_Human	1.24895737
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23749047
61	TCF4_23295773_ChIP-Seq_U87_Human	1.23342409
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.22784308
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22739689
64	STAT3_23295773_ChIP-Seq_U87_Human	1.22385829
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21235770
66	ELK1_19687146_ChIP-ChIP_HELA_Human	1.18713086
67	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17984837
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17921453
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17679994
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17178096
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16707678
72	VDR_23849224_ChIP-Seq_CD4+_Human	1.16405227
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16380107
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16199388
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.13102830
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.12883701
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12313882
78	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.11673050
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11619709
80	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11619268
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11243128
82	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.10873825
83	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10871208
84	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.10728117
85	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.10271948
86	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10271948
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09371796
88	CDX2_22108803_ChIP-Seq_LS180_Human	1.07022898
89	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05986009
90	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04495336
91	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04195760
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03742734
93	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.03064226
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02883476
95	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.02726233
96	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00235971
97	TAF2_19829295_ChIP-Seq_ESCs_Human	1.00229137
98	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99428090
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99385653
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98207801

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.98141303
2	MP0002102_abnormal_ear_morphology	2.88611070
3	MP0002837_dystrophic_cardiac_calcinosis	2.57986961
4	MP0003195_calcinosis	2.55613806
5	MP0005551_abnormal_eye_electrophysiolog	2.43653006
6	MP0005646_abnormal_pituitary_gland	2.39726330
7	MP0004885_abnormal_endolymph	2.36643177
8	MP0008872_abnormal_physiological_respon	2.30634957
9	MP0004147_increased_porphyrin_level	2.21878560
10	MP0002876_abnormal_thyroid_physiology	2.20762133
11	MP0003787_abnormal_imprinting	2.17968203
12	MP0003646_muscle_fatigue	2.15905041
13	MP0006072_abnormal_retinal_apoptosis	2.10377217
14	MP0008875_abnormal_xenobiotic_pharmacok	2.00281113
15	MP0001968_abnormal_touch/_nociception	1.99206815
16	MP0006292_abnormal_olfactory_placode	1.92672313
17	MP0000372_irregular_coat_pigmentation	1.90806704
18	MP0001986_abnormal_taste_sensitivity	1.89233480
19	MP0005645_abnormal_hypothalamus_physiol	1.86213657
20	MP0002163_abnormal_gland_morphology	1.85309119
21	MP0002736_abnormal_nociception_after	1.82194094
22	MP0004142_abnormal_muscle_tone	1.80008280
23	MP0009745_abnormal_behavioral_response	1.78851381
24	MP0005253_abnormal_eye_physiology	1.73606368
25	MP0001485_abnormal_pinna_reflex	1.69738873
26	MP0001501_abnormal_sleep_pattern	1.68071795
27	MP0003880_abnormal_central_pattern	1.58706299
28	MP0002138_abnormal_hepatobiliary_system	1.55677101
29	MP0002638_abnormal_pupillary_reflex	1.54495982
30	MP0002272_abnormal_nervous_system	1.52185597
31	MP0005671_abnormal_response_to	1.51465868
32	MP0009046_muscle_twitch	1.50600669
33	MP0004742_abnormal_vestibular_system	1.50012761
34	MP0002653_abnormal_ependyma_morphology	1.49420843
35	MP0003011_delayed_dark_adaptation	1.49396912
36	MP0005379_endocrine/exocrine_gland_phen	1.49354517
37	MP0000631_abnormal_neuroendocrine_gland	1.47597761
38	MP0001486_abnormal_startle_reflex	1.45028644
39	MP0003283_abnormal_digestive_organ	1.44786934
40	MP0004043_abnormal_pH_regulation	1.44478748
41	MP0004145_abnormal_muscle_electrophysio	1.43773171
42	MP0001905_abnormal_dopamine_level	1.36029332
43	MP0001529_abnormal_vocalization	1.34228599
44	MP0003252_abnormal_bile_duct	1.33934740
45	MP0003878_abnormal_ear_physiology	1.32788496
46	MP0005377_hearing/vestibular/ear_phenot	1.32788496
47	MP0000427_abnormal_hair_cycle	1.26650630
48	MP0000569_abnormal_digit_pigmentation	1.25461183
49	MP0005389_reproductive_system_phenotype	1.22311821
50	MP0005085_abnormal_gallbladder_physiolo	1.20457350
51	MP0005075_abnormal_melanosome_morpholog	1.18072745
52	MP0006276_abnormal_autonomic_nervous	1.17208851
53	MP0002938_white_spotting	1.17090929
54	MP0003136_yellow_coat_color	1.16117759
55	MP0005084_abnormal_gallbladder_morpholo	1.15921646
56	MP0002160_abnormal_reproductive_system	1.15742805
57	MP0001970_abnormal_pain_threshold	1.11316999
58	MP0001984_abnormal_olfaction	1.11252740
59	MP0002733_abnormal_thermal_nociception	1.10162103
60	MP0010386_abnormal_urinary_bladder	1.09667061
61	MP0002572_abnormal_emotion/affect_behav	1.08295152
62	MP0002557_abnormal_social/conspecific_i	1.08284660
63	MP0004133_heterotaxia	1.07911006
64	MP0005365_abnormal_bile_salt	1.03742202
65	MP0002234_abnormal_pharynx_morphology	1.01980426
66	MP0002254_reproductive_system_inflammat	1.00322173
67	MP0002064_seizures	0.99398312
68	MP0001919_abnormal_reproductive_system	0.97741512
69	MP0002095_abnormal_skin_pigmentation	0.96716170
70	MP0001764_abnormal_homeostasis	0.94099606
71	MP0004924_abnormal_behavior	0.93430412
72	MP0005386_behavior/neurological_phenoty	0.93430412
73	MP0000026_abnormal_inner_ear	0.93311510
74	MP0005174_abnormal_tail_pigmentation	0.92445647
75	MP0003718_maternal_effect	0.91015039
76	MP0001963_abnormal_hearing_physiology	0.90687724
77	MP0002067_abnormal_sensory_capabilities	0.89706739
78	MP0005636_abnormal_mineral_homeostasis	0.89567909
79	MP0006036_abnormal_mitochondrial_physio	0.89332374
80	MP0005195_abnormal_posterior_eye	0.86781156
81	MP0008995_early_reproductive_senescence	0.86707011
82	MP0009764_decreased_sensitivity_to	0.86001313
83	MP0002693_abnormal_pancreas_physiology	0.85527271
84	MP0002229_neurodegeneration	0.85260527
85	MP0001835_abnormal_antigen_presentation	0.85186645
86	MP0000230_abnormal_systemic_arterial	0.85135027
87	MP0002735_abnormal_chemical_nociception	0.84740604
88	MP0003137_abnormal_impulse_conducting	0.84389079
89	MP0010329_abnormal_lipoprotein_level	0.83014526
90	MP0005332_abnormal_amino_acid	0.80062858
91	MP0005410_abnormal_fertilization	0.79483446
92	MP0002063_abnormal_learning/memory/cond	0.78031887
93	MP0004215_abnormal_myocardial_fiber	0.77462518
94	MP0002752_abnormal_somatic_nervous	0.75874574
95	MP0005360_urolithiasis	0.75624261
96	MP0003635_abnormal_synaptic_transmissio	0.74490543
97	MP0008058_abnormal_DNA_repair	0.74473326
98	MP0008775_abnormal_heart_ventricle	0.73194197
99	MP0002751_abnormal_autonomic_nervous	0.72305399
100	MP0004019_abnormal_vitamin_homeostasis	0.70932731

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.32913312
2	Congenital stationary night blindness (HP:0007642)	4.14398261
3	Molar tooth sign on MRI (HP:0002419)	3.86242284
4	Abnormality of midbrain morphology (HP:0002418)	3.86242284
5	Pancreatic fibrosis (HP:0100732)	3.82855839
6	True hermaphroditism (HP:0010459)	3.72962737
7	Abnormality of the renal cortex (HP:0011035)	3.72093549
8	Nephronophthisis (HP:0000090)	3.49018084
9	Abnormality of the renal medulla (HP:0100957)	3.21003287
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.08680954
11	Attenuation of retinal blood vessels (HP:0007843)	3.03340186
12	Acute necrotizing encephalopathy (HP:0006965)	3.01000206
13	Type II lissencephaly (HP:0007260)	2.99301449
14	Pendular nystagmus (HP:0012043)	2.94797986
15	Renal cortical cysts (HP:0000803)	2.90619891
16	Medial flaring of the eyebrow (HP:0010747)	2.80780747
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.77678985
18	Mitochondrial inheritance (HP:0001427)	2.76634938
19	Tubular atrophy (HP:0000092)	2.75767582
20	Progressive macrocephaly (HP:0004481)	2.70181465
21	Methylmalonic acidemia (HP:0002912)	2.65992094
22	Abolished electroretinogram (ERG) (HP:0000550)	2.64157354
23	Increased CSF lactate (HP:0002490)	2.62730252
24	Acute encephalopathy (HP:0006846)	2.60224114
25	Abnormal mitochondria in muscle tissue (HP:0008316)	2.56146411
26	Increased corneal curvature (HP:0100692)	2.49558108
27	Keratoconus (HP:0000563)	2.49558108
28	Abnormality of alanine metabolism (HP:0010916)	2.47503980
29	Hyperalaninemia (HP:0003348)	2.47503980
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.47503980
31	Cystic liver disease (HP:0006706)	2.47410190
32	Hepatocellular necrosis (HP:0001404)	2.40674944
33	Decreased central vision (HP:0007663)	2.36454313
34	Methylmalonic aciduria (HP:0012120)	2.35706623
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.35642355
36	Abnormal drinking behavior (HP:0030082)	2.32969385
37	Polydipsia (HP:0001959)	2.32969385
38	Inability to walk (HP:0002540)	2.31921226
39	Hepatic necrosis (HP:0002605)	2.31229567
40	3-Methylglutaconic aciduria (HP:0003535)	2.30527095
41	Gaze-evoked nystagmus (HP:0000640)	2.29954123
42	Hyperventilation (HP:0002883)	2.28493970
43	Congenital, generalized hypertrichosis (HP:0004540)	2.27603633
44	Sclerocornea (HP:0000647)	2.26489144
45	Optic disc pallor (HP:0000543)	2.24532094
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.22043870
47	Polyuria (HP:0000103)	2.21214358
48	Large for gestational age (HP:0001520)	2.16101500
49	Chronic hepatic failure (HP:0100626)	2.15140318
50	IgG deficiency (HP:0004315)	2.14121372
51	Stomatitis (HP:0010280)	2.13312928
52	Hypoproteinemia (HP:0003075)	2.10714709
53	Asplenia (HP:0001746)	2.07595218
54	Lissencephaly (HP:0001339)	2.07147478
55	Progressive inability to walk (HP:0002505)	2.06165998
56	Thyroiditis (HP:0100646)	2.05550650
57	Intestinal atresia (HP:0011100)	2.05495826
58	Progressive cerebellar ataxia (HP:0002073)	2.01752383
59	Furrowed tongue (HP:0000221)	1.99400214
60	Lipid accumulation in hepatocytes (HP:0006561)	1.97229935
61	Congenital hepatic fibrosis (HP:0002612)	1.97089685
62	Gait imbalance (HP:0002141)	1.97029682
63	Nephrogenic diabetes insipidus (HP:0009806)	1.95720451
64	Congenital primary aphakia (HP:0007707)	1.93982179
65	Absent/shortened dynein arms (HP:0200106)	1.93612411
66	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.93612411
67	Hypothermia (HP:0002045)	1.91859690
68	Increased serum lactate (HP:0002151)	1.90299093
69	Increased hepatocellular lipid droplets (HP:0006565)	1.90237727
70	Male pseudohermaphroditism (HP:0000037)	1.87827380
71	Abnormal biliary tract physiology (HP:0012439)	1.85800182
72	Bile duct proliferation (HP:0001408)	1.85800182
73	Metabolic alkalosis (HP:0200114)	1.85512392
74	Genetic anticipation (HP:0003743)	1.84822086
75	Anencephaly (HP:0002323)	1.84678990
76	Postaxial foot polydactyly (HP:0001830)	1.83871412
77	Optic nerve hypoplasia (HP:0000609)	1.80920841
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.80135966
79	Constricted visual fields (HP:0001133)	1.79820273
80	Abnormal urine output (HP:0012590)	1.79620597
81	Elevated erythrocyte sedimentation rate (HP:0003565)	1.79580896
82	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.79094496
83	Chorioretinal atrophy (HP:0000533)	1.78173136
84	Disproportionate short-trunk short stature (HP:0003521)	1.74531404
85	Agitation (HP:0000713)	1.73546016
86	Hypoalbuminemia (HP:0003073)	1.73420227
87	Abnormal albumin level (HP:0012116)	1.73420227
88	Bony spicule pigmentary retinopathy (HP:0007737)	1.73100422
89	Cerebral edema (HP:0002181)	1.72621920
90	Cerebellar dysplasia (HP:0007033)	1.72564835
91	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.72105598
92	Hypomagnesemia (HP:0002917)	1.69801485
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.68789771
94	Retinal dysplasia (HP:0007973)	1.66186200
95	Renal Fanconi syndrome (HP:0001994)	1.65168990
96	Hyperglycinemia (HP:0002154)	1.65140970
97	Abnormality of vitamin B metabolism (HP:0004340)	1.64348122
98	Lactic acidosis (HP:0003128)	1.64254501
99	Stomach cancer (HP:0012126)	1.63398603
100	Congenital sensorineural hearing impairment (HP:0008527)	1.63073509

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.83067855
2	ADRBK2	3.52188346
3	MAP4K2	2.97123526
4	GRK1	2.93257059
5	TAOK3	2.85842504
6	ZAK	2.78521015
7	BMPR1B	2.65744340
8	NUAK1	2.50739923
9	TXK	2.50033951
10	PINK1	2.41502310
11	WNK4	2.38358216
12	WNK3	2.17485581
13	INSRR	1.92318381
14	CAMKK2	1.68122664
15	ACVR1B	1.65876169
16	MAP3K4	1.54380364
17	TLK1	1.49197618
18	OXSR1	1.45426690
19	TRIM28	1.39069131
20	MAPK13	1.35207192
21	MUSK	1.34482434
22	BCKDK	1.34196653
23	TEC	1.26645537
24	PAK3	1.24242563
25	MST4	1.22843726
26	MKNK2	1.19202866
27	TNIK	1.16875171
28	DAPK2	1.09266236
29	STK39	1.08174162
30	ADRBK1	1.06371145
31	DYRK2	0.99646780
32	CSNK1G1	0.94778277
33	VRK2	0.94765220
34	ITK	0.94046962
35	EIF2AK3	0.90423504
36	KDR	0.90034074
37	PRKCE	0.89424978
38	TIE1	0.89216017
39	CSNK1G3	0.87625383
40	BCR	0.87453403
41	CDK19	0.86489047
42	VRK1	0.84786036
43	CSNK1G2	0.84556198
44	PLK2	0.83520928
45	ERBB3	0.82187331
46	CASK	0.81701581
47	PRKCG	0.80838258
48	PRKCQ	0.78582809
49	PHKG1	0.78540398
50	PHKG2	0.78540398
51	TGFBR1	0.76358323
52	IKBKB	0.73019505
53	PIK3CA	0.72886380
54	CSNK1A1L	0.68630187
55	GRK7	0.67666225
56	NTRK2	0.65691182
57	STK16	0.65280402
58	MAP3K12	0.64054753
59	MAP4K1	0.62048139
60	NEK2	0.60036455
61	TNK2	0.58985856
62	NTRK3	0.58763189
63	NLK	0.58177201
64	PASK	0.57355663
65	PTK2B	0.57263100
66	MAP2K6	0.57130477
67	STK38L	0.56860181
68	FLT3	0.56728808
69	MKNK1	0.56428350
70	KIT	0.56299218
71	MAP2K7	0.56265922
72	FGFR2	0.55681358
73	CAMK1	0.53504868
74	PLK3	0.52905959
75	PRKACA	0.51923809
76	CCNB1	0.51535064
77	CAMK2A	0.51337700
78	SYK	0.51026691
79	MARK1	0.49721457
80	STK3	0.46314882
81	GRK6	0.46142596
82	EPHA4	0.45392005
83	RPS6KA5	0.45188729
84	GRK5	0.44716571
85	PRKCA	0.41942229
86	TAF1	0.40610551
87	MAPKAPK5	0.40231867
88	PKN1	0.40093311
89	CSNK1A1	0.39686162
90	BRSK2	0.39674997
91	CAMKK1	0.39181033
92	OBSCN	0.38873969
93	PRKCI	0.38853991
94	BTK	0.37472681
95	IGF1R	0.34187749
96	PRKAA2	0.33406651
97	PLK4	0.31875784
98	LCK	0.30978543
99	LYN	0.30468908
100	MAPKAPK3	0.30000371

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.84937264
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.79249880
3	Protein export_Homo sapiens_hsa03060	2.50791651
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.39314213
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.28855483
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.19697212
7	Parkinsons disease_Homo sapiens_hsa05012	2.17261406
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.08891650
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.02912071
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.01550026
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.99285880
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.91396691
13	Butanoate metabolism_Homo sapiens_hsa00650	1.87519649
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.78202442
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.72812632
16	Caffeine metabolism_Homo sapiens_hsa00232	1.72473768
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.72322908
18	Homologous recombination_Homo sapiens_hsa03440	1.70482856
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.68960160
20	Proteasome_Homo sapiens_hsa03050	1.64347474
21	RNA polymerase_Homo sapiens_hsa03020	1.61879360
22	Nicotine addiction_Homo sapiens_hsa05033	1.58975137
23	Asthma_Homo sapiens_hsa05310	1.56911781
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.54221720
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.51893684
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.50883254
27	Propanoate metabolism_Homo sapiens_hsa00640	1.50505526
28	Basal transcription factors_Homo sapiens_hsa03022	1.48606698
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.44740146
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.33101512
31	Alzheimers disease_Homo sapiens_hsa05010	1.31442129
32	Allograft rejection_Homo sapiens_hsa05330	1.29867495
33	Peroxisome_Homo sapiens_hsa04146	1.29282568
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.28998098
35	Huntingtons disease_Homo sapiens_hsa05016	1.28420889
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.28268557
37	Type I diabetes mellitus_Homo sapiens_hsa04940	1.26918600
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.26012534
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.24089003
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.21682769
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.21441774
42	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.21099499
43	Olfactory transduction_Homo sapiens_hsa04740	1.19433010
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.15138559
45	RNA degradation_Homo sapiens_hsa03018	1.14279344
46	Sulfur metabolism_Homo sapiens_hsa00920	1.13080979
47	Morphine addiction_Homo sapiens_hsa05032	1.12769612
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11345500
49	Regulation of autophagy_Homo sapiens_hsa04140	1.09523528
50	One carbon pool by folate_Homo sapiens_hsa00670	1.07968323
51	Taste transduction_Homo sapiens_hsa04742	1.07705496
52	Retinol metabolism_Homo sapiens_hsa00830	1.04823249
53	Graft-versus-host disease_Homo sapiens_hsa05332	1.03881614
54	Fanconi anemia pathway_Homo sapiens_hsa03460	1.03869274
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99409980
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.97057519
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.94941103
58	Ribosome_Homo sapiens_hsa03010	0.91294317
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.89640461
60	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.88292730
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86408982
62	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.80917808
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79984577
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.79043395
65	Insulin secretion_Homo sapiens_hsa04911	0.77191093
66	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.76815588
67	ABC transporters_Homo sapiens_hsa02010	0.76652037
68	Serotonergic synapse_Homo sapiens_hsa04726	0.76452184
69	GABAergic synapse_Homo sapiens_hsa04727	0.75535313
70	Purine metabolism_Homo sapiens_hsa00230	0.72318908
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68749087
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66086006
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.65919989
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.65617331
75	Circadian entrainment_Homo sapiens_hsa04713	0.64228238
76	Rheumatoid arthritis_Homo sapiens_hsa05323	0.64069531
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.64044078
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63124030
79	Metabolic pathways_Homo sapiens_hsa01100	0.62373895
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.61451894
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61140962
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60955796
83	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.58177426
84	Salivary secretion_Homo sapiens_hsa04970	0.56120560
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54617861
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.54465783
87	Mineral absorption_Homo sapiens_hsa04978	0.54134069
88	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46517745
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.45714402
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45294538
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45231124
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.44232827
93	Antigen processing and presentation_Homo sapiens_hsa04612	0.44205568
94	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43675498
95	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42926005
96	Non-homologous end-joining_Homo sapiens_hsa03450	0.39121484
97	Fatty acid degradation_Homo sapiens_hsa00071	0.37148199
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.32340190
99	Histidine metabolism_Homo sapiens_hsa00340	0.29938066
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.28851353

RPL21P135

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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