RPL21P136

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)5.22932535
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.09817931
3ATP synthesis coupled proton transport (GO:0015986)5.09817931
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.08530647
5positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.79052950
6ribosomal small subunit assembly (GO:0000028)4.55328182
7kynurenine metabolic process (GO:0070189)4.50731044
8platelet dense granule organization (GO:0060155)4.50659672
9regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.45489844
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.43547041
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.15628764
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.15628764
13NADH dehydrogenase complex assembly (GO:0010257)4.15628764
14protein complex biogenesis (GO:0070271)4.04113589
15viral transcription (GO:0019083)4.01770209
16translational termination (GO:0006415)3.99786708
17protein neddylation (GO:0045116)3.91578973
18negative regulation of calcium ion transport into cytosol (GO:0010523)3.91115033
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.87053707
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.86678891
21dopamine transport (GO:0015872)3.77051600
22respiratory electron transport chain (GO:0022904)3.74947692
23substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.72990993
24substrate-independent telencephalic tangential migration (GO:0021826)3.72990993
25ribosomal small subunit biogenesis (GO:0042274)3.72985152
26regulation of immunoglobulin secretion (GO:0051023)3.72885337
27electron transport chain (GO:0022900)3.72559431
28somite development (GO:0061053)3.68884071
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.68552841
30behavioral response to nicotine (GO:0035095)3.67791281
31indole-containing compound catabolic process (GO:0042436)3.66632550
32indolalkylamine catabolic process (GO:0046218)3.66632550
33tryptophan catabolic process (GO:0006569)3.66632550
34cotranslational protein targeting to membrane (GO:0006613)3.63503648
35protein targeting to ER (GO:0045047)3.61782143
36mitochondrial respiratory chain complex assembly (GO:0033108)3.60893540
37protein K6-linked ubiquitination (GO:0085020)3.59019327
38detection of light stimulus involved in sensory perception (GO:0050962)3.51423494
39detection of light stimulus involved in visual perception (GO:0050908)3.51423494
40establishment of protein localization to endoplasmic reticulum (GO:0072599)3.48542148
41ribosomal large subunit biogenesis (GO:0042273)3.40813181
42translational elongation (GO:0006414)3.39917742
43oxidative demethylation (GO:0070989)3.37783375
44protein localization to endoplasmic reticulum (GO:0070972)3.36141437
45aldehyde catabolic process (GO:0046185)3.34409093
46proteasome assembly (GO:0043248)3.32997654
47chaperone-mediated protein transport (GO:0072321)3.30232700
48neuron fate determination (GO:0048664)3.29883078
49termination of RNA polymerase III transcription (GO:0006386)3.26086644
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.26086644
51tryptophan metabolic process (GO:0006568)3.25034736
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.24158109
53regulation of isotype switching to IgG isotypes (GO:0048302)3.23262425
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.20408246
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.20408246
56ATP biosynthetic process (GO:0006754)3.19935432
57negative regulation of transcription regulatory region DNA binding (GO:2000678)3.18307055
58regulation of neurotransmitter uptake (GO:0051580)3.09379800
59anterograde synaptic vesicle transport (GO:0048490)3.08793867
60negative regulation of mast cell activation (GO:0033004)3.08374755
61DNA deamination (GO:0045006)3.07095278
62purine nucleoside triphosphate biosynthetic process (GO:0009145)3.00860303
63mannosylation (GO:0097502)2.99372394
64rRNA modification (GO:0000154)2.99361863
65purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.98982558
66indolalkylamine metabolic process (GO:0006586)2.98618978
67preassembly of GPI anchor in ER membrane (GO:0016254)2.96722595
68lactate metabolic process (GO:0006089)2.94861680
69water-soluble vitamin biosynthetic process (GO:0042364)2.92780169
70neuronal action potential propagation (GO:0019227)2.90200749
71negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.90133316
72amine catabolic process (GO:0009310)2.88331740
73cellular biogenic amine catabolic process (GO:0042402)2.88331740
74benzene-containing compound metabolic process (GO:0042537)2.87645227
75cellular protein complex disassembly (GO:0043624)2.85033628
76negative regulation of heart rate (GO:0010459)2.83597279
77viral life cycle (GO:0019058)2.82919001
78translation (GO:0006412)2.79091721
79protein localization to cilium (GO:0061512)2.78529473
80response to redox state (GO:0051775)2.74296650
81positive regulation of meiosis (GO:0045836)2.74167817
82dentate gyrus development (GO:0021542)2.73685762
83negative regulation of B cell apoptotic process (GO:0002903)2.71006701
84DNA demethylation (GO:0080111)2.70787874
85positive regulation of DNA recombination (GO:0045911)2.70509169
86peristalsis (GO:0030432)2.70222013
87regulation of meiosis I (GO:0060631)2.69737273
88hydrogen ion transmembrane transport (GO:1902600)2.66819552
89axoneme assembly (GO:0035082)2.63456831
90xenobiotic catabolic process (GO:0042178)2.63366013
91translational initiation (GO:0006413)2.62220498
92organelle disassembly (GO:1903008)2.62098967
93cellular component biogenesis (GO:0044085)2.61980244
94regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.61851148
95regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.61851148
96base-excision repair, AP site formation (GO:0006285)2.59682463
97aromatic amino acid family catabolic process (GO:0009074)2.58252694
98epithelial cilium movement (GO:0003351)2.56275750
99positive regulation of meiotic cell cycle (GO:0051446)2.55257659
100proton transport (GO:0015992)2.55137003

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.43457344
2EST1_17652178_ChIP-ChIP_JURKAT_Human2.91961051
3ZNF274_21170338_ChIP-Seq_K562_Hela2.87989935
4FLI1_27457419_Chip-Seq_LIVER_Mouse2.76541196
5VDR_22108803_ChIP-Seq_LS180_Human2.72792448
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68532380
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67200452
8ELK1_19687146_ChIP-ChIP_HELA_Human2.33114959
9EWS_26573619_Chip-Seq_HEK293_Human2.26522144
10GBX2_23144817_ChIP-Seq_PC3_Human2.23587493
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.21647198
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10413554
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04452599
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04238707
15EZH2_22144423_ChIP-Seq_EOC_Human2.03180560
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98998998
17ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98247156
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.93555879
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93058463
20FUS_26573619_Chip-Seq_HEK293_Human1.89510057
21P300_19829295_ChIP-Seq_ESCs_Human1.89178967
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87096148
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84270751
24ER_23166858_ChIP-Seq_MCF-7_Human1.75988024
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75153905
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72407394
27TAF15_26573619_Chip-Seq_HEK293_Human1.71352317
28MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.68134472
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66411432
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.64022123
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63547268
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63280296
33MYC_18940864_ChIP-ChIP_HL60_Human1.60624052
34VDR_23849224_ChIP-Seq_CD4+_Human1.60533688
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56744352
36TP53_22573176_ChIP-Seq_HFKS_Human1.55469952
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.53228955
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.50711117
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49549686
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46746446
41ETV2_25802403_ChIP-Seq_MESCs_Mouse1.46253088
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.45397665
43IGF1R_20145208_ChIP-Seq_DFB_Human1.45104788
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42192089
45KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38105749
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.29228451
47AR_20517297_ChIP-Seq_VCAP_Human1.28682716
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.27766216
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.27405852
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27294074
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26908005
52CRX_20693478_ChIP-Seq_RETINA_Mouse1.25901632
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23990961
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.23990961
55CBP_20019798_ChIP-Seq_JUKART_Human1.23988699
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23988699
57NANOG_19829295_ChIP-Seq_ESCs_Human1.23498231
58SOX2_19829295_ChIP-Seq_ESCs_Human1.23498231
59FOXH1_21741376_ChIP-Seq_EPCs_Human1.22567207
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.22503222
61ERG_20517297_ChIP-Seq_VCAP_Human1.20645156
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20510366
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19698249
64RUNX2_22187159_ChIP-Seq_PCA_Human1.19582611
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18698780
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18038799
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17852706
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.17622254
69HOXB7_26014856_ChIP-Seq_BT474_Human1.17404691
70P53_22387025_ChIP-Seq_ESCs_Mouse1.14892815
71IRF1_19129219_ChIP-ChIP_H3396_Human1.13375508
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12129189
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.11176933
74AR_21572438_ChIP-Seq_LNCaP_Human1.10705724
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09781367
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08353173
77NANOG_20526341_ChIP-Seq_ESCs_Human1.07608720
78TCF4_22108803_ChIP-Seq_LS180_Human1.06936166
79RBPJ_21746931_ChIP-Seq_IB4_Human1.06357340
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06229738
81STAT3_23295773_ChIP-Seq_U87_Human1.05073428
82FOXP3_21729870_ChIP-Seq_TREG_Human1.04539844
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03570215
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03240968
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03178428
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02994806
87BCAT_22108803_ChIP-Seq_LS180_Human1.02905068
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02214406
89AR_25329375_ChIP-Seq_VCAP_Human1.01285655
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01034632
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.00709385
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00364000
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.00160043
94NCOR_22424771_ChIP-Seq_293T_Human0.99951799
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98618734
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.98217196
97P300_18555785_Chip-Seq_ESCs_Mouse0.97855959
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.97449954
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97197205
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96440673

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.44116069
2MP0002938_white_spotting3.01688975
3MP0000372_irregular_coat_pigmentation2.97487779
4MP0002102_abnormal_ear_morphology2.91505898
5MP0002837_dystrophic_cardiac_calcinosis2.74816711
6MP0003136_yellow_coat_color2.71290580
7MP0008877_abnormal_DNA_methylation2.69950060
8MP0005171_absent_coat_pigmentation2.63179024
9MP0008872_abnormal_physiological_respon2.49489308
10MP0009379_abnormal_foot_pigmentation2.35132148
11MP0005084_abnormal_gallbladder_morpholo2.26765105
12MP0008875_abnormal_xenobiotic_pharmacok2.18551063
13MP0005645_abnormal_hypothalamus_physiol2.13685171
14MP0002138_abnormal_hepatobiliary_system2.13168338
15MP0003787_abnormal_imprinting2.11025387
16MP0005646_abnormal_pituitary_gland2.10846211
17MP0003011_delayed_dark_adaptation2.05367064
18MP0003646_muscle_fatigue2.02340916
19MP0003195_calcinosis1.97869871
20MP0004142_abnormal_muscle_tone1.97298630
21MP0001293_anophthalmia1.93251935
22MP0005551_abnormal_eye_electrophysiolog1.92130867
23MP0004885_abnormal_endolymph1.78619651
24MP0003283_abnormal_digestive_organ1.73015910
25MP0001485_abnormal_pinna_reflex1.68515272
26MP0002234_abnormal_pharynx_morphology1.65671809
27MP0008995_early_reproductive_senescence1.64336719
28MP0000631_abnormal_neuroendocrine_gland1.59455544
29MP0000566_synostosis1.56104244
30MP0002163_abnormal_gland_morphology1.51679849
31MP0005174_abnormal_tail_pigmentation1.49385811
32MP0003718_maternal_effect1.43557643
33MP0003186_abnormal_redox_activity1.42573102
34MP0003122_maternal_imprinting1.42041872
35MP0001984_abnormal_olfaction1.42040963
36MP0010030_abnormal_orbit_morphology1.41526582
37MP0001501_abnormal_sleep_pattern1.40591977
38MP0005408_hypopigmentation1.40400276
39MP0005379_endocrine/exocrine_gland_phen1.38267518
40MP0002638_abnormal_pupillary_reflex1.31881919
41MP0003300_gastrointestinal_ulcer1.31228078
42MP0002653_abnormal_ependyma_morphology1.29740130
43MP0001968_abnormal_touch/_nociception1.24672949
44MP0001440_abnormal_grooming_behavior1.20768050
45MP0006072_abnormal_retinal_apoptosis1.20656355
46MP0002736_abnormal_nociception_after1.19534995
47MP0008058_abnormal_DNA_repair1.19170612
48MP0002272_abnormal_nervous_system1.18358307
49MP0000049_abnormal_middle_ear1.17673235
50MP0001986_abnormal_taste_sensitivity1.13867298
51MP0004381_abnormal_hair_follicle1.13826518
52MP0004147_increased_porphyrin_level1.13532905
53MP0003121_genomic_imprinting1.13198296
54MP0000613_abnormal_salivary_gland1.12183847
55MP0008789_abnormal_olfactory_epithelium1.11267809
56MP0005253_abnormal_eye_physiology1.09772254
57MP0002095_abnormal_skin_pigmentation1.08749315
58MP0000569_abnormal_digit_pigmentation1.07136401
59MP0001835_abnormal_antigen_presentation1.06671226
60MP0003937_abnormal_limbs/digits/tail_de1.01126534
61MP0003786_premature_aging1.01035726
62MP0002876_abnormal_thyroid_physiology0.98215406
63MP0005671_abnormal_response_to0.97305889
64MP0006054_spinal_hemorrhage0.93669332
65MP0009745_abnormal_behavioral_response0.92990882
66MP0001873_stomach_inflammation0.91750814
67MP0001919_abnormal_reproductive_system0.89876041
68MP0006036_abnormal_mitochondrial_physio0.89777415
69MP0005389_reproductive_system_phenotype0.88935855
70MP0001486_abnormal_startle_reflex0.88671054
71MP0000026_abnormal_inner_ear0.87593544
72MP0004019_abnormal_vitamin_homeostasis0.85919489
73MP0002277_abnormal_respiratory_mucosa0.85355021
74MP0000427_abnormal_hair_cycle0.84300072
75MP0005195_abnormal_posterior_eye0.82671781
76MP0005248_abnormal_Harderian_gland0.82400010
77MP0001529_abnormal_vocalization0.82324071
78MP0004133_heterotaxia0.82303157
79MP0001905_abnormal_dopamine_level0.80547845
80MP0002877_abnormal_melanocyte_morpholog0.78160516
81MP0002557_abnormal_social/conspecific_i0.78046842
82MP0001348_abnormal_lacrimal_gland0.77048569
83MP0008961_abnormal_basal_metabolism0.76245306
84MP0003878_abnormal_ear_physiology0.76036099
85MP0005377_hearing/vestibular/ear_phenot0.76036099
86MP0003567_abnormal_fetal_cardiomyocyte0.74663981
87MP0010386_abnormal_urinary_bladder0.73269622
88MP0004043_abnormal_pH_regulation0.73168641
89MP0009764_decreased_sensitivity_to0.71859250
90MP0006035_abnormal_mitochondrial_morpho0.71618632
91MP0001970_abnormal_pain_threshold0.70889285
92MP0005075_abnormal_melanosome_morpholog0.69574249
93MP0006276_abnormal_autonomic_nervous0.69195695
94MP0002735_abnormal_chemical_nociception0.69110020
95MP0002233_abnormal_nose_morphology0.67794988
96MP0005636_abnormal_mineral_homeostasis0.67277967
97MP0003638_abnormal_response/metabolism_0.66250412
98MP0005167_abnormal_blood-brain_barrier0.66243484
99MP0002210_abnormal_sex_determination0.65981528
100MP0009046_muscle_twitch0.65058759

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.00417753
2Abnormality of midbrain morphology (HP:0002418)3.89352084
3Molar tooth sign on MRI (HP:0002419)3.89352084
4Congenital stationary night blindness (HP:0007642)3.83206030
5Reticulocytopenia (HP:0001896)3.77697423
6Mitochondrial inheritance (HP:0001427)3.69896446
7Acute encephalopathy (HP:0006846)3.57575334
8Stomatitis (HP:0010280)3.46427663
9Lipid accumulation in hepatocytes (HP:0006561)3.40219459
10Progressive macrocephaly (HP:0004481)3.36720616
11Abnormality of cells of the erythroid lineage (HP:0012130)3.36593532
12Type II lissencephaly (HP:0007260)3.32316598
13Pancreatic cysts (HP:0001737)3.32172390
14Increased CSF lactate (HP:0002490)3.29086357
15Stomach cancer (HP:0012126)3.26370129
16Increased hepatocellular lipid droplets (HP:0006565)3.25793826
17Abnormal mitochondria in muscle tissue (HP:0008316)3.25589761
18Nephronophthisis (HP:0000090)3.22979776
19Abnormality of the labia minora (HP:0012880)3.22489933
20Decreased central vision (HP:0007663)3.19939394
21Absent rod-and cone-mediated responses on ERG (HP:0007688)3.11368584
22Pancreatic fibrosis (HP:0100732)3.02926933
23Decreased electroretinogram (ERG) amplitude (HP:0000654)3.01495859
24Attenuation of retinal blood vessels (HP:0007843)3.00668109
25Abnormal number of erythroid precursors (HP:0012131)2.91948632
26Hepatocellular necrosis (HP:0001404)2.88680857
27Abnormality of the nasal septum (HP:0000419)2.86475765
28Hepatic necrosis (HP:0002605)2.78035481
29Abnormal rod and cone electroretinograms (HP:0008323)2.77719690
30Congenital, generalized hypertrichosis (HP:0004540)2.76332780
31Keratoconus (HP:0000563)2.74204970
32Increased corneal curvature (HP:0100692)2.74204970
33Cerebellar dysplasia (HP:0007033)2.71916201
34Abnormality of the renal medulla (HP:0100957)2.67720171
35Stenosis of the external auditory canal (HP:0000402)2.66925965
36True hermaphroditism (HP:0010459)2.66297550
37Colon cancer (HP:0003003)2.53460802
38Pendular nystagmus (HP:0012043)2.53184104
39Concave nail (HP:0001598)2.47498838
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.45205814
41Hypoplasia of the fovea (HP:0007750)2.45205814
42Optic disc pallor (HP:0000543)2.43144753
43Cerebral edema (HP:0002181)2.41954934
44Hypoplasia of the ulna (HP:0003022)2.38575056
45Macrocytic anemia (HP:0001972)2.36646575
46Hypothermia (HP:0002045)2.33985905
47Focal motor seizures (HP:0011153)2.29893688
48Rib fusion (HP:0000902)2.22193891
49Sclerocornea (HP:0000647)2.17766465
50Median cleft lip (HP:0000161)2.14711414
51Abnormality of the middle phalanges of the toes (HP:0010183)2.13824253
52Symphalangism affecting the phalanges of the hand (HP:0009773)2.13026088
53Absent thumb (HP:0009777)2.11127065
54IgG deficiency (HP:0004315)2.10838021
553-Methylglutaconic aciduria (HP:0003535)2.10461134
56Renal Fanconi syndrome (HP:0001994)2.10200114
57Abnormal ciliary motility (HP:0012262)2.08321649
58Constricted visual fields (HP:0001133)2.08029870
59Fused cervical vertebrae (HP:0002949)2.07979264
60Methylmalonic acidemia (HP:0002912)2.07610357
61Congenital sensorineural hearing impairment (HP:0008527)2.05085252
62Increased serum lactate (HP:0002151)2.04854760
63Abnormal respiratory motile cilium physiology (HP:0012261)2.03755516
64Septo-optic dysplasia (HP:0100842)2.01650162
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00583529
66Aplasia/Hypoplasia of the ulna (HP:0006495)1.99698144
67Respiratory failure (HP:0002878)1.98886167
68Glycosuria (HP:0003076)1.94741032
69Abnormality of urine glucose concentration (HP:0011016)1.94741032
70Arthropathy (HP:0003040)1.94600698
71Agitation (HP:0000713)1.92328595
72Growth hormone deficiency (HP:0000824)1.89928378
73Optic nerve hypoplasia (HP:0000609)1.89556633
74Congenital hepatic fibrosis (HP:0002612)1.88273913
75Cystic liver disease (HP:0006706)1.88144633
76Aplasia/hypoplasia of the uterus (HP:0008684)1.87623373
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87465468
78Lethargy (HP:0001254)1.87148831
79Exertional dyspnea (HP:0002875)1.87133131
80Hypomagnesemia (HP:0002917)1.86978158
81Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86822620
82Abnormality of macular pigmentation (HP:0008002)1.86503852
83Hyperphosphaturia (HP:0003109)1.86444186
84Postaxial foot polydactyly (HP:0001830)1.86008789
85Abnormality of the renal cortex (HP:0011035)1.85617426
86Forearm undergrowth (HP:0009821)1.79435242
87Increased intramyocellular lipid droplets (HP:0012240)1.78656798
88Azoospermia (HP:0000027)1.78246801
89Hypoplasia of the uterus (HP:0000013)1.77262245
90Pallor (HP:0000980)1.76515517
91Abnormality of cochlea (HP:0000375)1.75874761
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.74633427
93Lactic acidosis (HP:0003128)1.74631365
94Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.73197268
95Abnormality of the proximal phalanges of the hand (HP:0009834)1.72259431
96Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72001758
97Abnormality of the phalanges of the 5th finger (HP:0004213)1.71997814
98Abnormal drinking behavior (HP:0030082)1.71195418
99Polydipsia (HP:0001959)1.71195418
100Abnormal hemoglobin (HP:0011902)1.71184934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.36657506
2NUAK12.87830659
3GRK12.71856999
4STK38L2.60055248
5FGFR22.44437352
6ADRBK22.27429171
7TLK12.19875429
8PINK12.18773095
9ZAK2.18685868
10TAOK32.17204064
11BUB12.10747518
12WNK42.07997173
13STK391.96235264
14TRIM281.91197396
15WNK31.87657007
16PASK1.77833983
17BCKDK1.76640312
18MAP3K121.69001029
19DAPK21.68615186
20STK161.68403791
21MARK31.68159694
22TSSK61.67385039
23BMPR1B1.65781719
24PAK31.65354422
25STK241.63093174
26MST41.62033413
27MKNK11.56932680
28MKNK21.55641279
29MAP4K21.50031825
30CAMKK21.45486742
31OXSR11.32607026
32MYLK1.26670073
33PNCK1.24806602
34ERBB31.23247023
35TIE11.15612962
36INSRR1.11828195
37EPHA31.10304501
38PBK1.08350304
39PIK3CA1.04999333
40NEK11.00911284
41PRKD30.98694780
42NME10.95435773
43TGFBR10.86178241
44STK30.85826113
45PRKCH0.84676672
46VRK20.82119061
47PRKCG0.81384262
48DAPK30.80839357
49PLK40.80156834
50PRKCQ0.79047194
51PHKG20.78809909
52PHKG10.78809909
53PLK30.76047677
54DYRK20.71302482
55TNK20.70750887
56FER0.67640861
57SIK30.67486711
58VRK10.65524440
59IKBKB0.64345512
60TXK0.63381566
61PLK20.62935386
62FGFR10.62297999
63CAMK10.62224038
64TNIK0.60793671
65PRKCE0.56446019
66MAPK130.56423418
67TEC0.54913965
68ERBB20.53896629
69LRRK20.53498787
70ILK0.53490528
71PLK10.53007548
72OBSCN0.51959512
73ROCK10.51227683
74SRPK10.50295831
75CSNK1G10.50152779
76WEE10.48550382
77TRPM70.48546767
78BMPR20.47958096
79PRKCI0.47505673
80ITK0.46741619
81PRKACA0.45717090
82CASK0.45046808
83NEK20.44453956
84EIF2AK10.44386866
85NTRK30.43903374
86AURKB0.43738955
87MAPKAPK50.43179173
88ADRBK10.42683545
89CAMKK10.42098374
90CAMK40.41144146
91AURKA0.40419398
92CSNK2A20.39713893
93CAMK2A0.39176603
94DAPK10.37760681
95CCNB10.37339798
96PRKCA0.36877376
97PRKG10.36164653
98IGF1R0.35457369
99RPS6KA50.34774997
100CSNK2A10.34765395

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.84790157
2Oxidative phosphorylation_Homo sapiens_hsa001903.75806191
3Asthma_Homo sapiens_hsa053103.16132865
4Parkinsons disease_Homo sapiens_hsa050123.02304614
5Protein export_Homo sapiens_hsa030602.59409042
6RNA polymerase_Homo sapiens_hsa030202.54634363
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.45973760
8Proteasome_Homo sapiens_hsa030502.42607221
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34471787
10Allograft rejection_Homo sapiens_hsa053302.19283306
11Linoleic acid metabolism_Homo sapiens_hsa005912.12461034
12Huntingtons disease_Homo sapiens_hsa050162.07788546
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.06911721
14Alzheimers disease_Homo sapiens_hsa050102.03610956
15Autoimmune thyroid disease_Homo sapiens_hsa053201.96696635
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.88105668
17Cardiac muscle contraction_Homo sapiens_hsa042601.87383025
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78747406
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70239500
20RNA degradation_Homo sapiens_hsa030181.61286745
21Type I diabetes mellitus_Homo sapiens_hsa049401.61064807
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58479706
23Homologous recombination_Homo sapiens_hsa034401.50402275
24Phototransduction_Homo sapiens_hsa047441.48857638
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42646902
26Propanoate metabolism_Homo sapiens_hsa006401.40827204
27Tryptophan metabolism_Homo sapiens_hsa003801.33739041
28Caffeine metabolism_Homo sapiens_hsa002321.31580076
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28892144
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28573628
31Chemical carcinogenesis_Homo sapiens_hsa052041.28323239
32Graft-versus-host disease_Homo sapiens_hsa053321.23703095
33Basal transcription factors_Homo sapiens_hsa030221.18509274
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15089006
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12850024
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09042888
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03709109
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99681647
39Ether lipid metabolism_Homo sapiens_hsa005650.94132230
40One carbon pool by folate_Homo sapiens_hsa006700.93857422
41Fanconi anemia pathway_Homo sapiens_hsa034600.92305405
42Nicotine addiction_Homo sapiens_hsa050330.91962957
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91072868
44Arachidonic acid metabolism_Homo sapiens_hsa005900.90690420
45Butanoate metabolism_Homo sapiens_hsa006500.89230316
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.88472475
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87047894
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.87009149
49Retinol metabolism_Homo sapiens_hsa008300.84468384
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84050981
51Ovarian steroidogenesis_Homo sapiens_hsa049130.83358467
52Primary immunodeficiency_Homo sapiens_hsa053400.82705198
53Vitamin B6 metabolism_Homo sapiens_hsa007500.82326744
54Base excision repair_Homo sapiens_hsa034100.80994492
55Glutathione metabolism_Homo sapiens_hsa004800.80278077
56Steroid biosynthesis_Homo sapiens_hsa001000.79688614
57Nitrogen metabolism_Homo sapiens_hsa009100.76185088
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76176580
59Insulin secretion_Homo sapiens_hsa049110.76163970
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74645473
61Fatty acid elongation_Homo sapiens_hsa000620.71982647
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71968129
63Pyrimidine metabolism_Homo sapiens_hsa002400.70326700
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68554807
65beta-Alanine metabolism_Homo sapiens_hsa004100.68221661
66Purine metabolism_Homo sapiens_hsa002300.67427141
67Olfactory transduction_Homo sapiens_hsa047400.67209085
68Fat digestion and absorption_Homo sapiens_hsa049750.65428426
69Peroxisome_Homo sapiens_hsa041460.64356072
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63597196
71Spliceosome_Homo sapiens_hsa030400.63432290
72Salivary secretion_Homo sapiens_hsa049700.62707335
73Rheumatoid arthritis_Homo sapiens_hsa053230.62447430
74Metabolic pathways_Homo sapiens_hsa011000.59708210
75Mineral absorption_Homo sapiens_hsa049780.58847952
76Collecting duct acid secretion_Homo sapiens_hsa049660.57529662
77Taste transduction_Homo sapiens_hsa047420.52796879
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52481414
79Hematopoietic cell lineage_Homo sapiens_hsa046400.51812490
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50770980
81Folate biosynthesis_Homo sapiens_hsa007900.50240951
82Fatty acid degradation_Homo sapiens_hsa000710.49488342
83Nucleotide excision repair_Homo sapiens_hsa034200.49291375
84Starch and sucrose metabolism_Homo sapiens_hsa005000.44806461
85Amphetamine addiction_Homo sapiens_hsa050310.41116377
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.41048348
87RNA transport_Homo sapiens_hsa030130.39386509
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36448577
89Cocaine addiction_Homo sapiens_hsa050300.35779383
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33160623
91Morphine addiction_Homo sapiens_hsa050320.30721457
92Pancreatic secretion_Homo sapiens_hsa049720.30116182
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.28825400
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26882440
95Serotonergic synapse_Homo sapiens_hsa047260.25352086
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25268419
97Glutamatergic synapse_Homo sapiens_hsa047240.25109226
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.23522882
99Pyruvate metabolism_Homo sapiens_hsa006200.23471660
100Basal cell carcinoma_Homo sapiens_hsa052170.23270255

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