ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.10898419
2	ATP synthesis coupled proton transport (GO:0015986)	6.10898419
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.93303110
4	ribosomal small subunit assembly (GO:0000028)	5.48113065
5	behavioral response to nicotine (GO:0035095)	5.20015920
6	viral transcription (GO:0019083)	4.89317439
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.78051774
8	translational termination (GO:0006415)	4.76246141
9	protein complex biogenesis (GO:0070271)	4.72671985
10	protein neddylation (GO:0045116)	4.57303650
11	respiratory electron transport chain (GO:0022904)	4.54037844
12	electron transport chain (GO:0022900)	4.51558121
13	DNA deamination (GO:0045006)	4.51265144
14	chaperone-mediated protein transport (GO:0072321)	4.44815839
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.42210003
16	NADH dehydrogenase complex assembly (GO:0010257)	4.42210003
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.42210003
18	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.40721076
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.39866514
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.31526779
21	mitochondrial respiratory chain complex assembly (GO:0033108)	4.29160969
22	cotranslational protein targeting to membrane (GO:0006613)	4.28013784
23	protein targeting to ER (GO:0045047)	4.22603501
24	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.04336765
25	protein localization to endoplasmic reticulum (GO:0070972)	4.01097016
26	translational elongation (GO:0006414)	3.99362546
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.90105214
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.85299792
29	termination of RNA polymerase III transcription (GO:0006386)	3.82073186
30	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.82073186
31	ribosomal small subunit biogenesis (GO:0042274)	3.77894310
32	GTP biosynthetic process (GO:0006183)	3.71046316
33	maturation of SSU-rRNA (GO:0030490)	3.65644653
34	hydrogen ion transmembrane transport (GO:1902600)	3.57551344
35	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.52720581
36	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.49811843
37	ATP biosynthetic process (GO:0006754)	3.46933506
38	respiratory chain complex IV assembly (GO:0008535)	3.46907185
39	cytochrome complex assembly (GO:0017004)	3.44165580
40	cellular protein complex disassembly (GO:0043624)	3.42886529
41	viral life cycle (GO:0019058)	3.38842498
42	DNA double-strand break processing (GO:0000729)	3.36670621
43	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.36666894
44	regulation of cilium movement (GO:0003352)	3.35706992
45	proton transport (GO:0015992)	3.34809291
46	translational initiation (GO:0006413)	3.31578468
47	translation (GO:0006412)	3.31230062
48	kynurenine metabolic process (GO:0070189)	3.30644375
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.27936938
50	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.27936938
51	pseudouridine synthesis (GO:0001522)	3.27260463
52	hydrogen transport (GO:0006818)	3.25842356
53	negative regulation of T cell differentiation in thymus (GO:0033085)	3.18952460
54	ribosomal large subunit biogenesis (GO:0042273)	3.17113031
55	protein-cofactor linkage (GO:0018065)	3.14604660
56	tryptophan catabolic process (GO:0006569)	3.10241941
57	indole-containing compound catabolic process (GO:0042436)	3.10241941
58	indolalkylamine catabolic process (GO:0046218)	3.10241941
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.04219166
60	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.02674944
61	UTP biosynthetic process (GO:0006228)	3.01294857
62	proteasome assembly (GO:0043248)	2.99608739
63	regulation of immunoglobulin secretion (GO:0051023)	2.95793347
64	rRNA catabolic process (GO:0016075)	2.95791947
65	platelet dense granule organization (GO:0060155)	2.93356368
66	cellular component biogenesis (GO:0044085)	2.93345931
67	nonmotile primary cilium assembly (GO:0035058)	2.92043317
68	rRNA metabolic process (GO:0016072)	2.83479391
69	UTP metabolic process (GO:0046051)	2.81497331
70	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.81176176
71	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.80262638
72	protein complex disassembly (GO:0043241)	2.79499026
73	maturation of 5.8S rRNA (GO:0000460)	2.79357649
74	indolalkylamine metabolic process (GO:0006586)	2.78684108
75	rRNA processing (GO:0006364)	2.78285292
76	tRNA processing (GO:0008033)	2.76777082
77	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.75241673
78	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.75194228
79	regulation of microtubule-based movement (GO:0060632)	2.74798378
80	activated T cell proliferation (GO:0050798)	2.74725190
81	negative regulation of telomere maintenance (GO:0032205)	2.73105507
82	tryptophan metabolic process (GO:0006568)	2.73062134
83	protein targeting to membrane (GO:0006612)	2.68655683
84	macromolecular complex disassembly (GO:0032984)	2.68179464
85	negative regulation of appetite (GO:0032099)	2.67676419
86	negative regulation of response to food (GO:0032096)	2.67676419
87	rRNA modification (GO:0000154)	2.67405022
88	mRNA catabolic process (GO:0006402)	2.64855917
89	nucleoside triphosphate biosynthetic process (GO:0009142)	2.62890619
90	detection of light stimulus involved in visual perception (GO:0050908)	2.59818366
91	detection of light stimulus involved in sensory perception (GO:0050962)	2.59818366
92	positive regulation of protein homodimerization activity (GO:0090073)	2.59638421
93	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.58659541
94	aldehyde catabolic process (GO:0046185)	2.54031497
95	L-fucose catabolic process (GO:0042355)	2.53402015
96	fucose catabolic process (GO:0019317)	2.53402015
97	L-fucose metabolic process (GO:0042354)	2.53402015
98	CTP metabolic process (GO:0046036)	2.53061547
99	CTP biosynthetic process (GO:0006241)	2.53061547
100	replication fork processing (GO:0031297)	2.52252667

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.89625745
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.75946582
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.39726167
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.37837492
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.37734458
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02225947
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.02178510
8	VDR_22108803_ChIP-Seq_LS180_Human	2.81370046
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.56368768
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.47014012
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.39372126
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.33362843
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.27310582
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.11401916
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.05670639
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.05315834
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.03320434
18	IGF1R_20145208_ChIP-Seq_DFB_Human	2.02066534
19	EWS_26573619_Chip-Seq_HEK293_Human	1.93483162
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.92096348
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.78932883
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.73382645
23	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.72480507
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.66223368
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66049214
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.63754478
27	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.60582924
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.56794547
29	FUS_26573619_Chip-Seq_HEK293_Human	1.48156712
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46552141
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.44816036
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.44070290
33	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.43907914
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42095906
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42095906
36	P300_19829295_ChIP-Seq_ESCs_Human	1.41028243
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38930520
38	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.36212785
39	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34720885
40	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.33825398
41	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32497886
42	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.31860051
43	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31407026
44	TTF2_22483619_ChIP-Seq_HELA_Human	1.30392631
45	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.29982496
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29961385
47	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.29893319
48	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.29002613
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27489547
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27354721
51	GBX2_23144817_ChIP-Seq_PC3_Human	1.26265842
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.24414739
53	NCOR_22424771_ChIP-Seq_293T_Human	1.22172218
54	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.20068747
55	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.19379140
56	AR_20517297_ChIP-Seq_VCAP_Human	1.13125087
57	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11805570
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11778928
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11778928
60	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11677359
61	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10610145
62	REST_21632747_ChIP-Seq_MESCs_Mouse	1.09860844
63	MYC_19829295_ChIP-Seq_ESCs_Human	1.06961487
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06958228
65	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06165238
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05704758
67	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05238687
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04317110
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02644016
70	CBP_20019798_ChIP-Seq_JUKART_Human	1.02644016
71	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02283323
72	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01371424
73	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.00076510
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99893831
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99598037
76	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.99129492
77	TCF4_22108803_ChIP-Seq_LS180_Human	0.99009485
78	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98788833
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.98645808
80	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98595242
81	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.96538245
82	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.95808505
83	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.95655547
84	ERG_20517297_ChIP-Seq_VCAP_Human	0.95289954
85	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.95162807
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94470921
87	ERA_21632823_ChIP-Seq_H3396_Human	0.90063740
88	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89862963
89	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.89332914
90	P53_21459846_ChIP-Seq_SAOS-2_Human	0.88828491
91	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.87706114
92	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.87264796
93	BCAT_22108803_ChIP-Seq_LS180_Human	0.86492576
94	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.86080832
95	GATA3_26560356_Chip-Seq_TH2_Human	0.85964706
96	HTT_18923047_ChIP-ChIP_STHdh_Human	0.85576342
97	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.85102995
98	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.84796208
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.83980688
100	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.83820285

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.44937197
2	MP0008877_abnormal_DNA_methylation	3.16518831
3	MP0006292_abnormal_olfactory_placode	3.12798641
4	MP0006072_abnormal_retinal_apoptosis	2.58976877
5	MP0003787_abnormal_imprinting	2.40158221
6	MP0008872_abnormal_physiological_respon	2.35447434
7	MP0001348_abnormal_lacrimal_gland	2.32145399
8	MP0008875_abnormal_xenobiotic_pharmacok	2.28040169
9	MP0004142_abnormal_muscle_tone	2.23743709
10	MP0001529_abnormal_vocalization	2.22500259
11	MP0005671_abnormal_response_to	2.19437499
12	MP0001968_abnormal_touch/_nociception	2.13626804
13	MP0003122_maternal_imprinting	2.06763654
14	MP0004885_abnormal_endolymph	2.05365707
15	MP0001984_abnormal_olfaction	2.03195337
16	MP0003011_delayed_dark_adaptation	2.01023616
17	MP0001835_abnormal_antigen_presentation	1.96498981
18	MP0002102_abnormal_ear_morphology	1.90729911
19	MP0005551_abnormal_eye_electrophysiolog	1.82027610
20	MP0002163_abnormal_gland_morphology	1.74254172
21	MP0005645_abnormal_hypothalamus_physiol	1.73028587
22	MP0001919_abnormal_reproductive_system	1.72611797
23	MP0001986_abnormal_taste_sensitivity	1.72151324
24	MP0002272_abnormal_nervous_system	1.70635686
25	MP0003646_muscle_fatigue	1.68425709
26	MP0002876_abnormal_thyroid_physiology	1.65639598
27	MP0001485_abnormal_pinna_reflex	1.63456622
28	MP0002736_abnormal_nociception_after	1.62243990
29	MP0005389_reproductive_system_phenotype	1.61341138
30	MP0003121_genomic_imprinting	1.60365731
31	MP0002837_dystrophic_cardiac_calcinosis	1.54518324
32	MP0005253_abnormal_eye_physiology	1.51755691
33	MP0003195_calcinosis	1.48196769
34	MP0009745_abnormal_behavioral_response	1.45950313
35	MP0000372_irregular_coat_pigmentation	1.42555581
36	MP0005646_abnormal_pituitary_gland	1.41563111
37	MP0008789_abnormal_olfactory_epithelium	1.38797009
38	MP0005377_hearing/vestibular/ear_phenot	1.37344582
39	MP0003878_abnormal_ear_physiology	1.37344582
40	MP0001970_abnormal_pain_threshold	1.36594649
41	MP0003186_abnormal_redox_activity	1.36316132
42	MP0003786_premature_aging	1.31637203
43	MP0001293_anophthalmia	1.30925414
44	MP0001905_abnormal_dopamine_level	1.29340457
45	MP0001486_abnormal_startle_reflex	1.28892725
46	MP0005084_abnormal_gallbladder_morpholo	1.25469710
47	MP0001440_abnormal_grooming_behavior	1.24694593
48	MP0002572_abnormal_emotion/affect_behav	1.23541472
49	MP0002160_abnormal_reproductive_system	1.22265420
50	MP0002938_white_spotting	1.19828085
51	MP0004742_abnormal_vestibular_system	1.18888741
52	MP0000631_abnormal_neuroendocrine_gland	1.13496167
53	MP0004924_abnormal_behavior	1.10242619
54	MP0005386_behavior/neurological_phenoty	1.10242619
55	MP0002557_abnormal_social/conspecific_i	1.08736301
56	MP0002735_abnormal_chemical_nociception	1.08101816
57	MP0002733_abnormal_thermal_nociception	1.07857795
58	MP0008058_abnormal_DNA_repair	1.07473754
59	MP0006276_abnormal_autonomic_nervous	1.07081828
60	MP0009046_muscle_twitch	1.05875183
61	MP0005379_endocrine/exocrine_gland_phen	1.04827924
62	MP0002638_abnormal_pupillary_reflex	1.04242561
63	MP0002734_abnormal_mechanical_nocicepti	1.03869862
64	MP0003123_paternal_imprinting	1.03854827
65	MP0009785_altered_susceptibility_to	1.03460862
66	MP0004145_abnormal_muscle_electrophysio	1.01306641
67	MP0000427_abnormal_hair_cycle	0.98754331
68	MP0006036_abnormal_mitochondrial_physio	0.96149474
69	MP0004133_heterotaxia	0.93923435
70	MP0001800_abnormal_humoral_immune	0.93521785
71	MP0005195_abnormal_posterior_eye	0.92579485
72	MP0002063_abnormal_learning/memory/cond	0.92197613
73	MP0005499_abnormal_olfactory_system	0.91701293
74	MP0005394_taste/olfaction_phenotype	0.91701293
75	MP0005387_immune_system_phenotype	0.91362139
76	MP0001790_abnormal_immune_system	0.91362139
77	MP0002752_abnormal_somatic_nervous	0.90893182
78	MP0002148_abnormal_hypersensitivity_rea	0.89654818
79	MP0003635_abnormal_synaptic_transmissio	0.88382033
80	MP0004019_abnormal_vitamin_homeostasis	0.87022895
81	MP0001963_abnormal_hearing_physiology	0.86812245
82	MP0003283_abnormal_digestive_organ	0.86367563
83	MP0000569_abnormal_digit_pigmentation	0.86027701
84	MP0002064_seizures	0.85204259
85	MP0008995_early_reproductive_senescence	0.85158336
86	MP0002210_abnormal_sex_determination	0.84743422
87	MP0003866_abnormal_defecation	0.84613260
88	MP0004147_increased_porphyrin_level	0.84598964
89	MP0002067_abnormal_sensory_capabilities	0.84202339
90	MP0002184_abnormal_innervation	0.83399593
91	MP0010386_abnormal_urinary_bladder	0.83194627
92	MP0001501_abnormal_sleep_pattern	0.82310643
93	MP0005423_abnormal_somatic_nervous	0.81567540
94	MP0000778_abnormal_nervous_system	0.78713207
95	MP0002090_abnormal_vision	0.76188151
96	MP0005636_abnormal_mineral_homeostasis	0.74722545
97	MP0008775_abnormal_heart_ventricle	0.74663258
98	MP0003718_maternal_effect	0.74628499
99	MP0009764_decreased_sensitivity_to	0.72951822
100	MP0005000_abnormal_immune_tolerance	0.72101720

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.86208808
2	Increased hepatocellular lipid droplets (HP:0006565)	4.31994395
3	Mitochondrial inheritance (HP:0001427)	4.28686936
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.17665003
5	Acute encephalopathy (HP:0006846)	4.16275544
6	Progressive macrocephaly (HP:0004481)	4.14042294
7	Lipid accumulation in hepatocytes (HP:0006561)	4.05893785
8	Increased CSF lactate (HP:0002490)	3.95645995
9	Congenital, generalized hypertrichosis (HP:0004540)	3.70100326
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.52202074
11	Hepatocellular necrosis (HP:0001404)	3.49686357
12	Stomatitis (HP:0010280)	3.44071709
13	Reticulocytopenia (HP:0001896)	3.32763645
14	Renal Fanconi syndrome (HP:0001994)	3.29165049
15	Pancreatic cysts (HP:0001737)	3.22667097
16	Abnormal number of erythroid precursors (HP:0012131)	3.20937391
17	Pancreatic fibrosis (HP:0100732)	3.06797674
18	Molar tooth sign on MRI (HP:0002419)	2.99176689
19	Abnormality of midbrain morphology (HP:0002418)	2.99176689
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.97709453
21	Congenital stationary night blindness (HP:0007642)	2.97267271
22	Hepatic necrosis (HP:0002605)	2.95386557
23	Pendular nystagmus (HP:0012043)	2.91443031
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.87229069
25	3-Methylglutaconic aciduria (HP:0003535)	2.86205490
26	Cerebral edema (HP:0002181)	2.85000539
27	Optic disc pallor (HP:0000543)	2.82873896
28	Septo-optic dysplasia (HP:0100842)	2.77801359
29	Exertional dyspnea (HP:0002875)	2.76899584
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.67386926
31	Absent thumb (HP:0009777)	2.67158138
32	Increased intramyocellular lipid droplets (HP:0012240)	2.64548471
33	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.58719448
34	Macrocytic anemia (HP:0001972)	2.57148728
35	IgG deficiency (HP:0004315)	2.55347587
36	Type II lissencephaly (HP:0007260)	2.49401089
37	Asplenia (HP:0001746)	2.48212642
38	Increased serum lactate (HP:0002151)	2.46455339
39	Supernumerary spleens (HP:0009799)	2.37951597
40	Abnormality of the labia minora (HP:0012880)	2.36816928
41	Bile duct proliferation (HP:0001408)	2.33922948
42	Abnormal biliary tract physiology (HP:0012439)	2.33922948
43	True hermaphroditism (HP:0010459)	2.32757379
44	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.31593772
45	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.31593772
46	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.29532038
47	Abnormal drinking behavior (HP:0030082)	2.25732107
48	Polydipsia (HP:0001959)	2.25732107
49	Abolished electroretinogram (ERG) (HP:0000550)	2.24819618
50	Hypothermia (HP:0002045)	2.22363121
51	Medial flaring of the eyebrow (HP:0010747)	2.20536303
52	Nephronophthisis (HP:0000090)	2.19462222
53	Increased muscle lipid content (HP:0009058)	2.19325733
54	Abnormality of the renal cortex (HP:0011035)	2.18375229
55	Aplasia/hypoplasia of the uterus (HP:0008684)	2.17784136
56	Leukodystrophy (HP:0002415)	2.17782698
57	Elevated erythrocyte sedimentation rate (HP:0003565)	2.16690281
58	Sclerocornea (HP:0000647)	2.16040201
59	Lactic acidosis (HP:0003128)	2.11359905
60	Colon cancer (HP:0003003)	2.09198906
61	Respiratory failure (HP:0002878)	2.05422267
62	Glycosuria (HP:0003076)	2.04526939
63	Abnormality of urine glucose concentration (HP:0011016)	2.04526939
64	Abnormality of renal resorption (HP:0011038)	2.04404926
65	Hypoplasia of the uterus (HP:0000013)	2.02281326
66	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.98207071
67	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.96232249
68	Abnormality of the renal medulla (HP:0100957)	1.95791897
69	Optic nerve hypoplasia (HP:0000609)	1.95554439
70	Fibular aplasia (HP:0002990)	1.94862865
71	Exercise intolerance (HP:0003546)	1.94492129
72	Hypoplasia of the radius (HP:0002984)	1.93820237
73	Respiratory difficulties (HP:0002880)	1.93483755
74	Rib fusion (HP:0000902)	1.93009879
75	Parakeratosis (HP:0001036)	1.90945991
76	Growth hormone deficiency (HP:0000824)	1.88198890
77	Dyschromatopsia (HP:0007641)	1.87766211
78	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.87386111
79	Pallor (HP:0000980)	1.85936170
80	Forearm undergrowth (HP:0009821)	1.85683002
81	Lethargy (HP:0001254)	1.84588412
82	Postaxial foot polydactyly (HP:0001830)	1.84496770
83	Methylmalonic acidemia (HP:0002912)	1.82021207
84	Gait imbalance (HP:0002141)	1.81255299
85	Abnormal respiratory motile cilium physiology (HP:0012261)	1.81124866
86	Hyperphosphaturia (HP:0003109)	1.78926025
87	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.78432230
88	Meckel diverticulum (HP:0002245)	1.77650845
89	Cystic liver disease (HP:0006706)	1.76132652
90	Decreased central vision (HP:0007663)	1.76011097
91	Thyroiditis (HP:0100646)	1.75907294
92	Abnormality of the ileum (HP:0001549)	1.75621077
93	Increased IgM level (HP:0003496)	1.74147752
94	Cerebellar dysplasia (HP:0007033)	1.73249540
95	Absent septum pellucidum (HP:0001331)	1.72772259
96	Congenital primary aphakia (HP:0007707)	1.72642664
97	Polyuria (HP:0000103)	1.71841739
98	Testicular atrophy (HP:0000029)	1.67554495
99	Tubular atrophy (HP:0000092)	1.67471775
100	Adrenal hypoplasia (HP:0000835)	1.67243203

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.40702229
2	TXK	3.33243307
3	ADRBK2	2.98208263
4	ZAK	2.55972979
5	NUAK1	2.54287552
6	WNK4	2.52363039
7	DYRK2	2.45781629
8	TLK1	2.39103664
9	WNK3	2.16864377
10	STK16	2.03665420
11	GRK1	1.96156702
12	PNCK	1.92834585
13	MAP4K2	1.91547154
14	NEK1	1.69520631
15	TAOK3	1.69081874
16	CDK19	1.69016433
17	OXSR1	1.68890099
18	PINK1	1.66935375
19	VRK2	1.63868117
20	NME1	1.52699123
21	CAMKK2	1.49557776
22	PLK4	1.45305702
23	INSRR	1.44370117
24	STK39	1.39170377
25	EIF2AK1	1.37627880
26	VRK1	1.23539514
27	PHKG1	1.21966971
28	PHKG2	1.21966971
29	PASK	1.19597869
30	EIF2AK3	1.18028908
31	MAP4K1	1.16953138
32	MST4	1.16875621
33	TIE1	1.15659384
34	TNIK	1.12277500
35	MAP2K7	1.07062487
36	BMPR1B	1.03558828
37	CAMKK1	1.03251050
38	PLK3	1.02571319
39	MAP3K12	1.02320883
40	SRPK1	1.01684302
41	PBK	1.01133555
42	TAF1	1.01005617
43	PRKCG	0.98778511
44	BCKDK	0.97916519
45	TYRO3	0.97294372
46	PAK3	0.92501167
47	TEC	0.92396427
48	BUB1	0.91708753
49	EPHA3	0.91452876
50	CDC7	0.84294745
51	NEK2	0.82811846
52	MKNK2	0.79278886
53	MAP3K4	0.76700627
54	DAPK2	0.75333133
55	MINK1	0.74724046
56	ADRBK1	0.73167719
57	PIK3CA	0.70352080
58	MAP2K6	0.66450747
59	IKBKB	0.65255472
60	SGK223	0.64986443
61	SGK494	0.64986443
62	FES	0.64385473
63	CAMK1	0.63238523
64	STK38L	0.61043075
65	ITK	0.60432400
66	SIK2	0.59965301
67	PRKCH	0.59337000
68	PLK1	0.58553166
69	PLK2	0.57765185
70	PRKACA	0.56724952
71	PRKCE	0.55893743
72	BTK	0.55720372
73	STK11	0.55686308
74	FGFR2	0.55486394
75	NTRK2	0.54137035
76	TRIM28	0.53050511
77	PRKCQ	0.52658612
78	CSNK2A2	0.51269210
79	RPS6KA6	0.49097189
80	CSNK1A1	0.48726937
81	KIT	0.48725694
82	ATR	0.48351815
83	DAPK3	0.47398302
84	CSNK1G1	0.45872583
85	MARK1	0.45328991
86	SYK	0.45166869
87	MUSK	0.45045613
88	LIMK1	0.44733126
89	AURKB	0.44648299
90	NME2	0.43563331
91	PRKCA	0.43233649
92	GRK6	0.42907030
93	OBSCN	0.42860743
94	ALK	0.42128362
95	MYLK	0.42059873
96	CSNK2A1	0.41000099
97	ERBB3	0.39989533
98	RPS6KA5	0.39952849
99	PRKCD	0.38730484
100	AKT3	0.37919965

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.35289330
2	Ribosome_Homo sapiens_hsa03010	4.34103750
3	Parkinsons disease_Homo sapiens_hsa05012	3.52083310
4	Protein export_Homo sapiens_hsa03060	2.98723269
5	RNA polymerase_Homo sapiens_hsa03020	2.96520876
6	Proteasome_Homo sapiens_hsa03050	2.82914668
7	Caffeine metabolism_Homo sapiens_hsa00232	2.74272577
8	Alzheimers disease_Homo sapiens_hsa05010	2.43117900
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.42074048
10	Huntingtons disease_Homo sapiens_hsa05016	2.39010718
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.20783153
12	Asthma_Homo sapiens_hsa05310	2.17979407
13	RNA degradation_Homo sapiens_hsa03018	2.09790473
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.90731627
15	Allograft rejection_Homo sapiens_hsa05330	1.83077597
16	Homologous recombination_Homo sapiens_hsa03440	1.78652314
17	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.71550145
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.70220358
19	Phototransduction_Homo sapiens_hsa04744	1.66666796
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.61354677
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.60183976
22	Basal transcription factors_Homo sapiens_hsa03022	1.52656901
23	Primary immunodeficiency_Homo sapiens_hsa05340	1.50690338
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.46768667
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.42221416
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.41489829
27	Mismatch repair_Homo sapiens_hsa03430	1.30293672
28	One carbon pool by folate_Homo sapiens_hsa00670	1.27774794
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.26634267
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.21076822
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.18236743
32	Graft-versus-host disease_Homo sapiens_hsa05332	1.16378062
33	Type I diabetes mellitus_Homo sapiens_hsa04940	1.13196877
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.11773445
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.10863776
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08458061
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.99894849
38	Tryptophan metabolism_Homo sapiens_hsa00380	0.99285040
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.99006404
40	Purine metabolism_Homo sapiens_hsa00230	0.98355114
41	Spliceosome_Homo sapiens_hsa03040	0.96686634
42	Nicotine addiction_Homo sapiens_hsa05033	0.93357935
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88803694
44	DNA replication_Homo sapiens_hsa03030	0.88392072
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.88278514
46	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87006860
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.85687772
48	Steroid biosynthesis_Homo sapiens_hsa00100	0.85603681
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81960950
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.80417456
51	Morphine addiction_Homo sapiens_hsa05032	0.78963341
52	RNA transport_Homo sapiens_hsa03013	0.77201684
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.76949812
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76611108
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.74533843
56	Olfactory transduction_Homo sapiens_hsa04740	0.72604944
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72241033
58	Taste transduction_Homo sapiens_hsa04742	0.71009270
59	Retinol metabolism_Homo sapiens_hsa00830	0.67839889
60	Metabolic pathways_Homo sapiens_hsa01100	0.65772631
61	Butanoate metabolism_Homo sapiens_hsa00650	0.65314955
62	Propanoate metabolism_Homo sapiens_hsa00640	0.65155976
63	Peroxisome_Homo sapiens_hsa04146	0.65075133
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64395716
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63094375
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.60801601
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60794858
68	Non-homologous end-joining_Homo sapiens_hsa03450	0.59049709
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.58989199
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58556169
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.54866647
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.53620344
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.51494128
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49597192
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49457221
76	GABAergic synapse_Homo sapiens_hsa04727	0.48722223
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48518394
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.48495690
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.46970855
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44001173
81	Insulin secretion_Homo sapiens_hsa04911	0.43292626
82	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.42201374
83	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.41715718
84	Serotonergic synapse_Homo sapiens_hsa04726	0.41692455
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.38677719
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36580654
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36275768
88	Salivary secretion_Homo sapiens_hsa04970	0.34585950
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34294208
90	Base excision repair_Homo sapiens_hsa03410	0.33747039
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33530097
92	Sulfur relay system_Homo sapiens_hsa04122	0.31610701
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.31610527
94	Regulation of autophagy_Homo sapiens_hsa04140	0.29748661
95	Circadian entrainment_Homo sapiens_hsa04713	0.28069621
96	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24023155
97	Mineral absorption_Homo sapiens_hsa04978	0.21616462
98	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.21389041
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.20943402
100	Glutathione metabolism_Homo sapiens_hsa00480	0.20140265

RPL21P17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »