ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.44164482
2	ATP synthesis coupled proton transport (GO:0015986)	5.44164482
3	ribosomal small subunit assembly (GO:0000028)	5.16839192
4	viral transcription (GO:0019083)	5.01362833
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.90515253
6	behavioral response to nicotine (GO:0035095)	4.90437361
7	translational termination (GO:0006415)	4.84415476
8	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.54649241
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.52974441
10	cotranslational protein targeting to membrane (GO:0006613)	4.46172122
11	protein targeting to ER (GO:0045047)	4.42187422
12	protein neddylation (GO:0045116)	4.39293707
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.26281976
14	protein localization to endoplasmic reticulum (GO:0070972)	4.23945379
15	translational elongation (GO:0006414)	4.18250773
16	protein complex biogenesis (GO:0070271)	4.03760646
17	electron transport chain (GO:0022900)	3.98009348
18	respiratory electron transport chain (GO:0022904)	3.95758019
19	NADH dehydrogenase complex assembly (GO:0010257)	3.95572694
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.95572694
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.95572694
22	DNA deamination (GO:0045006)	3.93551806
23	maturation of SSU-rRNA (GO:0030490)	3.88757430
24	ribosomal large subunit biogenesis (GO:0042273)	3.81363298
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.80936271
26	ribosomal small subunit biogenesis (GO:0042274)	3.67952909
27	viral life cycle (GO:0019058)	3.58723680
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.57961343
29	cellular protein complex disassembly (GO:0043624)	3.54422260
30	chaperone-mediated protein transport (GO:0072321)	3.50709088
31	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.46963742
32	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.46963742
33	water-soluble vitamin biosynthetic process (GO:0042364)	3.46888831
34	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.46129819
35	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.29032723
36	hydrogen ion transmembrane transport (GO:1902600)	3.28463355
37	translational initiation (GO:0006413)	3.25200036
38	ATP biosynthetic process (GO:0006754)	3.19597931
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.19536668
40	respiratory chain complex IV assembly (GO:0008535)	3.19332417
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.18409067
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.16789166
43	translation (GO:0006412)	3.15444543
44	termination of RNA polymerase III transcription (GO:0006386)	3.15188261
45	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.15188261
46	GTP biosynthetic process (GO:0006183)	3.14644331
47	proton transport (GO:0015992)	3.10695753
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.09799396
49	hydrogen transport (GO:0006818)	3.05441066
50	negative regulation of heart rate (GO:0010459)	3.05068980
51	nonmotile primary cilium assembly (GO:0035058)	3.02266128
52	platelet dense granule organization (GO:0060155)	3.01622565
53	indolalkylamine metabolic process (GO:0006586)	2.96377980
54	regulation of cilium movement (GO:0003352)	2.96112913
55	L-fucose catabolic process (GO:0042355)	2.91245671
56	fucose catabolic process (GO:0019317)	2.91245671
57	L-fucose metabolic process (GO:0042354)	2.91245671
58	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.90402872
59	protein targeting to membrane (GO:0006612)	2.87268101
60	regulation of isotype switching to IgG isotypes (GO:0048302)	2.83775811
61	tryptophan catabolic process (GO:0006569)	2.83643699
62	indole-containing compound catabolic process (GO:0042436)	2.83643699
63	indolalkylamine catabolic process (GO:0046218)	2.83643699
64	protein complex disassembly (GO:0043241)	2.83361600
65	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.78879202
66	macromolecular complex disassembly (GO:0032984)	2.74905454
67	cytochrome complex assembly (GO:0017004)	2.74535014
68	cellular component biogenesis (GO:0044085)	2.73921963
69	response to pheromone (GO:0019236)	2.73098113
70	GPI anchor metabolic process (GO:0006505)	2.72289509
71	epithelial cilium movement (GO:0003351)	2.68614979
72	negative regulation of T cell differentiation in thymus (GO:0033085)	2.68609510
73	kynurenine metabolic process (GO:0070189)	2.67993667
74	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.67691622
75	axoneme assembly (GO:0035082)	2.67679447
76	parturition (GO:0007567)	2.66910643
77	protein polyglutamylation (GO:0018095)	2.65600860
78	piRNA metabolic process (GO:0034587)	2.64950809
79	protein-cofactor linkage (GO:0018065)	2.63907752
80	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.63164688
81	interferon-gamma production (GO:0032609)	2.61681667
82	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.54946700
83	negative regulation of appetite (GO:0032099)	2.54870724
84	negative regulation of response to food (GO:0032096)	2.54870724
85	positive regulation of prostaglandin secretion (GO:0032308)	2.54738856
86	mannosylation (GO:0097502)	2.53666366
87	preassembly of GPI anchor in ER membrane (GO:0016254)	2.52420599
88	cellular ketone body metabolic process (GO:0046950)	2.52230732
89	UTP metabolic process (GO:0046051)	2.51893877
90	somite development (GO:0061053)	2.49391346
91	UTP biosynthetic process (GO:0006228)	2.49105309
92	GPI anchor biosynthetic process (GO:0006506)	2.47700408
93	S-adenosylmethionine metabolic process (GO:0046500)	2.47315002
94	tRNA processing (GO:0008033)	2.47069580
95	positive regulation of fatty acid transport (GO:2000193)	2.46033022
96	rRNA catabolic process (GO:0016075)	2.44962899
97	spliceosomal complex assembly (GO:0000245)	2.43807914
98	mRNA catabolic process (GO:0006402)	2.40148712
99	proteasome assembly (GO:0043248)	2.39440391
100	tryptophan metabolic process (GO:0006568)	2.38315719

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.86885835
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.66402148
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.43072779
4	VDR_22108803_ChIP-Seq_LS180_Human	2.88092663
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.73360796
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.65345550
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.57667470
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.55390385
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.25176054
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.18623781
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.98599676
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.94576577
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.90628050
14	VDR_23849224_ChIP-Seq_CD4+_Human	1.89145560
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.86917981
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.79492949
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.79282670
18	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73257789
19	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69503759
20	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.69040333
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66722408
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.63039582
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.62755027
24	EWS_26573619_Chip-Seq_HEK293_Human	1.58863546
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.57494899
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.55564697
27	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.53017545
28	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.52947476
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52289227
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.51998042
31	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.51855289
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.51601111
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51153060
34	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.50015798
35	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.45748426
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.45486368
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44117244
38	FUS_26573619_Chip-Seq_HEK293_Human	1.43634452
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.40286245
40	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.38552249
41	AR_20517297_ChIP-Seq_VCAP_Human	1.36774355
42	P300_19829295_ChIP-Seq_ESCs_Human	1.35426099
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33451726
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33451726
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.29916305
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29887662
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29887662
48	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29020028
49	TAF2_19829295_ChIP-Seq_ESCs_Human	1.28617352
50	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.28185930
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27650650
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.27650650
53	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27023306
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25890507
55	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.24805573
56	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.23391648
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23230805
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21288540
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19941364
60	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.19754062
61	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.19630650
62	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.17620347
63	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.17583442
64	NCOR_22424771_ChIP-Seq_293T_Human	1.17017337
65	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16402396
66	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.15965136
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15196398
68	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.14099438
69	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12992819
70	BCAT_22108803_ChIP-Seq_LS180_Human	1.10874403
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10790241
72	MYC_19829295_ChIP-Seq_ESCs_Human	1.10474924
73	GATA3_26560356_Chip-Seq_TH2_Human	1.10050523
74	GBX2_23144817_ChIP-Seq_PC3_Human	1.09486152
75	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.07345131
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06585775
77	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06237687
78	ERA_21632823_ChIP-Seq_H3396_Human	1.06178221
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.04750001
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03374458
81	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03044223
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02964411
83	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02770178
84	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02420422
85	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.01771453
86	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.01559078
87	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.01111833
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00990191
89	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.99159705
90	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98743077
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98669269
92	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97441471
93	TTF2_22483619_ChIP-Seq_HELA_Human	0.97405544
94	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97148056
95	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93424184
96	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.92011396
97	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.90540473
98	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.90503203
99	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90503203
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.89686694

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.70184086
2	MP0006292_abnormal_olfactory_placode	3.02152440
3	MP0003787_abnormal_imprinting	2.86070465
4	MP0001835_abnormal_antigen_presentation	2.74434191
5	MP0008877_abnormal_DNA_methylation	2.47103585
6	MP0004142_abnormal_muscle_tone	2.40634020
7	MP0006072_abnormal_retinal_apoptosis	2.35503862
8	MP0003646_muscle_fatigue	2.28041520
9	MP0002163_abnormal_gland_morphology	2.24379197
10	MP0005671_abnormal_response_to	2.18016804
11	MP0001986_abnormal_taste_sensitivity	2.02658105
12	MP0002837_dystrophic_cardiac_calcinosis	1.99180483
13	MP0002102_abnormal_ear_morphology	1.96861028
14	MP0005646_abnormal_pituitary_gland	1.93433651
15	MP0004147_increased_porphyrin_level	1.92547678
16	MP0001968_abnormal_touch/_nociception	1.91524921
17	MP0005551_abnormal_eye_electrophysiolog	1.89337719
18	MP0008872_abnormal_physiological_respon	1.89317637
19	MP0005377_hearing/vestibular/ear_phenot	1.85354600
20	MP0003878_abnormal_ear_physiology	1.85354600
21	MP0004885_abnormal_endolymph	1.84217485
22	MP0002876_abnormal_thyroid_physiology	1.81344760
23	MP0002653_abnormal_ependyma_morphology	1.78957008
24	MP0000372_irregular_coat_pigmentation	1.76108468
25	MP0008875_abnormal_xenobiotic_pharmacok	1.75211464
26	MP0003880_abnormal_central_pattern	1.69812027
27	MP0002138_abnormal_hepatobiliary_system	1.66679741
28	MP0006276_abnormal_autonomic_nervous	1.66184880
29	MP0008789_abnormal_olfactory_epithelium	1.65810001
30	MP0002638_abnormal_pupillary_reflex	1.61919301
31	MP0001984_abnormal_olfaction	1.59978068
32	MP0005645_abnormal_hypothalamus_physiol	1.57869337
33	MP0005379_endocrine/exocrine_gland_phen	1.56832455
34	MP0004145_abnormal_muscle_electrophysio	1.53559465
35	MP0002272_abnormal_nervous_system	1.51793660
36	MP0005253_abnormal_eye_physiology	1.45827594
37	MP0002736_abnormal_nociception_after	1.41292519
38	MP0003122_maternal_imprinting	1.36343790
39	MP0003195_calcinosis	1.33272349
40	MP0003011_delayed_dark_adaptation	1.32056307
41	MP0001905_abnormal_dopamine_level	1.31204300
42	MP0001873_stomach_inflammation	1.30186804
43	MP0005389_reproductive_system_phenotype	1.29037794
44	MP0009745_abnormal_behavioral_response	1.28062870
45	MP0005084_abnormal_gallbladder_morpholo	1.25673403
46	MP0002234_abnormal_pharynx_morphology	1.24975255
47	MP0005075_abnormal_melanosome_morpholog	1.24522261
48	MP0001529_abnormal_vocalization	1.24251717
49	MP0001919_abnormal_reproductive_system	1.22969836
50	MP0000685_abnormal_immune_system	1.21514788
51	MP0003806_abnormal_nucleotide_metabolis	1.19291572
52	MP0009046_muscle_twitch	1.19035534
53	MP0001485_abnormal_pinna_reflex	1.18071976
54	MP0001970_abnormal_pain_threshold	1.17256309
55	MP0005387_immune_system_phenotype	1.16228976
56	MP0001790_abnormal_immune_system	1.16228976
57	MP0004742_abnormal_vestibular_system	1.15472401
58	MP0005394_taste/olfaction_phenotype	1.15040795
59	MP0005499_abnormal_olfactory_system	1.15040795
60	MP0002160_abnormal_reproductive_system	1.14835499
61	MP0002938_white_spotting	1.14193673
62	MP0000631_abnormal_neuroendocrine_gland	1.14123669
63	MP0008775_abnormal_heart_ventricle	1.12862854
64	MP0001348_abnormal_lacrimal_gland	1.12681836
65	MP0003121_genomic_imprinting	1.10965043
66	MP0001440_abnormal_grooming_behavior	1.10425225
67	MP0002148_abnormal_hypersensitivity_rea	1.09776664
68	MP0004043_abnormal_pH_regulation	1.09732436
69	MP0003186_abnormal_redox_activity	1.09405269
70	MP0009764_decreased_sensitivity_to	1.04466765
71	MP0001800_abnormal_humoral_immune	1.04220518
72	MP0001486_abnormal_startle_reflex	0.98578376
73	MP0005195_abnormal_posterior_eye	0.98449922
74	MP0002557_abnormal_social/conspecific_i	0.97885109
75	MP0002572_abnormal_emotion/affect_behav	0.97642644
76	MP0001502_abnormal_circadian_rhythm	0.96246114
77	MP0002733_abnormal_thermal_nociception	0.96063887
78	MP0003866_abnormal_defecation	0.95738127
79	MP0001501_abnormal_sleep_pattern	0.94609694
80	MP0006036_abnormal_mitochondrial_physio	0.93319201
81	MP0001293_anophthalmia	0.89898629
82	MP0009785_altered_susceptibility_to	0.89067834
83	MP0005636_abnormal_mineral_homeostasis	0.86579025
84	MP0005423_abnormal_somatic_nervous	0.86197994
85	MP0002734_abnormal_mechanical_nocicepti	0.84828718
86	MP0005000_abnormal_immune_tolerance	0.82739447
87	MP0002277_abnormal_respiratory_mucosa	0.81169278
88	MP0002184_abnormal_innervation	0.80985902
89	MP0002752_abnormal_somatic_nervous	0.79741196
90	MP0005332_abnormal_amino_acid	0.79710580
91	MP0001963_abnormal_hearing_physiology	0.78886291
92	MP0004133_heterotaxia	0.78556848
93	MP0002723_abnormal_immune_serum	0.78030704
94	MP0000427_abnormal_hair_cycle	0.77382891
95	MP0002095_abnormal_skin_pigmentation	0.76664191
96	MP0000230_abnormal_systemic_arterial	0.76310324
97	MP0003123_paternal_imprinting	0.76030619
98	MP0002735_abnormal_chemical_nociception	0.75222497
99	MP0000026_abnormal_inner_ear	0.74402298
100	MP0002067_abnormal_sensory_capabilities	0.71531645

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.78611520
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.19586590
3	Mitochondrial inheritance (HP:0001427)	4.18836701
4	Acute encephalopathy (HP:0006846)	4.10465965
5	Progressive macrocephaly (HP:0004481)	4.03601391
6	Molar tooth sign on MRI (HP:0002419)	3.98217730
7	Abnormality of midbrain morphology (HP:0002418)	3.98217730
8	Hepatocellular necrosis (HP:0001404)	3.77638594
9	3-Methylglutaconic aciduria (HP:0003535)	3.77184300
10	Increased CSF lactate (HP:0002490)	3.69839407
11	Pancreatic cysts (HP:0001737)	3.55692643
12	Congenital, generalized hypertrichosis (HP:0004540)	3.40883884
13	Congenital stationary night blindness (HP:0007642)	3.35808223
14	Hepatic necrosis (HP:0002605)	3.27772341
15	Reticulocytopenia (HP:0001896)	3.25116879
16	Pancreatic fibrosis (HP:0100732)	3.14679870
17	Abnormality of cells of the erythroid lineage (HP:0012130)	3.05765782
18	Increased hepatocellular lipid droplets (HP:0006565)	3.05207305
19	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.94583034
20	Nephronophthisis (HP:0000090)	2.94039033
21	Lipid accumulation in hepatocytes (HP:0006561)	2.93593224
22	Medial flaring of the eyebrow (HP:0010747)	2.90225228
23	Cerebral edema (HP:0002181)	2.85207011
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.80397222
25	Optic disc pallor (HP:0000543)	2.78782296
26	Type II lissencephaly (HP:0007260)	2.74745424
27	Abolished electroretinogram (ERG) (HP:0000550)	2.67016845
28	IgG deficiency (HP:0004315)	2.60853069
29	True hermaphroditism (HP:0010459)	2.55408819
30	Renal Fanconi syndrome (HP:0001994)	2.54760632
31	Stomatitis (HP:0010280)	2.50665470
32	Macrocytic anemia (HP:0001972)	2.44311205
33	Increased serum lactate (HP:0002151)	2.41650185
34	Abnormality of the renal medulla (HP:0100957)	2.40868010
35	Methylmalonic acidemia (HP:0002912)	2.38338899
36	Abnormality of the renal cortex (HP:0011035)	2.37835711
37	Increased intramyocellular lipid droplets (HP:0012240)	2.36703435
38	Leukodystrophy (HP:0002415)	2.29626887
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.29186935
40	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.28108517
41	Lactic acidosis (HP:0003128)	2.26974825
42	Abnormal number of erythroid precursors (HP:0012131)	2.25518262
43	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.25425377
44	Absent/shortened dynein arms (HP:0200106)	2.25425377
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.24360670
46	Hypoproteinemia (HP:0003075)	2.22496906
47	Gait imbalance (HP:0002141)	2.19900785
48	Congenital primary aphakia (HP:0007707)	2.17696752
49	Asplenia (HP:0001746)	2.16947823
50	Abnormal ciliary motility (HP:0012262)	2.16378296
51	Abnormal drinking behavior (HP:0030082)	2.15838593
52	Polydipsia (HP:0001959)	2.15838593
53	Elevated erythrocyte sedimentation rate (HP:0003565)	2.11388234
54	Exertional dyspnea (HP:0002875)	2.10280953
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.09398463
56	Abnormality of alanine metabolism (HP:0010916)	2.09398463
57	Hyperalaninemia (HP:0003348)	2.09398463
58	Nephrogenic diabetes insipidus (HP:0009806)	2.08451949
59	Sclerocornea (HP:0000647)	2.07749270
60	Cystic liver disease (HP:0006706)	2.07451115
61	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.03301106
62	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.03301106
63	Respiratory failure (HP:0002878)	2.02505066
64	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.00651035
65	Increased muscle lipid content (HP:0009058)	1.99722393
66	Abnormality of DNA repair (HP:0003254)	1.99695035
67	Stenosis of the external auditory canal (HP:0000402)	1.99114708
68	Cerebellar dysplasia (HP:0007033)	1.98793602
69	Methylmalonic aciduria (HP:0012120)	1.98694727
70	Absent thumb (HP:0009777)	1.98643794
71	Attenuation of retinal blood vessels (HP:0007843)	1.95783832
72	Pendular nystagmus (HP:0012043)	1.94475503
73	Abnormal respiratory motile cilium physiology (HP:0012261)	1.93351052
74	Renal cortical cysts (HP:0000803)	1.92694736
75	Abnormal respiratory epithelium morphology (HP:0012253)	1.91828549
76	Abnormal respiratory motile cilium morphology (HP:0005938)	1.91828549
77	Hypoplasia of the pons (HP:0012110)	1.91749703
78	Tubular atrophy (HP:0000092)	1.90509499
79	Abnormality of the prostate (HP:0008775)	1.89300398
80	Aplasia/hypoplasia of the uterus (HP:0008684)	1.89130726
81	Lethargy (HP:0001254)	1.88928785
82	Adrenal hypoplasia (HP:0000835)	1.87658308
83	Pallor (HP:0000980)	1.87343759
84	Abnormality of renal resorption (HP:0011038)	1.86786635
85	Hypoplasia of the ulna (HP:0003022)	1.84400029
86	Abnormality of the pons (HP:0007361)	1.84025399
87	Agitation (HP:0000713)	1.82363818
88	Hyperglycinemia (HP:0002154)	1.81842579
89	Type 2 muscle fiber atrophy (HP:0003554)	1.81139169
90	Increased IgM level (HP:0003496)	1.80585157
91	Exercise intolerance (HP:0003546)	1.80285028
92	Chronic hepatic failure (HP:0100626)	1.80281573
93	Polyuria (HP:0000103)	1.79219394
94	Constricted visual fields (HP:0001133)	1.78737821
95	Delayed CNS myelination (HP:0002188)	1.77824184
96	Glycosuria (HP:0003076)	1.70802029
97	Abnormality of urine glucose concentration (HP:0011016)	1.70802029
98	Decreased central vision (HP:0007663)	1.70675121
99	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.69156722
100	Postaxial foot polydactyly (HP:0001830)	1.68759681

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.34196798
2	WNK4	2.95787096
3	MAP4K2	2.88832020
4	CDK19	2.83662680
5	ADRBK2	2.83660837
6	TLK1	2.76112288
7	ZAK	2.65302365
8	NUAK1	2.54984388
9	GRK1	2.46981455
10	FRK	2.45134138
11	TAOK3	2.43973785
12	STK16	2.42002905
13	PINK1	2.11697402
14	TIE1	1.84378292
15	DYRK2	1.69913271
16	MAP3K12	1.69508888
17	MAP4K1	1.56738038
18	WNK3	1.53907465
19	BCKDK	1.50986351
20	PIK3CA	1.50853016
21	OXSR1	1.42492371
22	BMPR2	1.39402684
23	PASK	1.38090032
24	ITK	1.37697463
25	TEC	1.36517965
26	CAMKK2	1.28900910
27	STK39	1.27331940
28	KIT	1.23856535
29	BMPR1B	1.21964800
30	MAP3K4	1.13769872
31	MST4	1.05270709
32	IKBKB	1.02008765
33	TRIM28	1.00027805
34	PHKG1	0.99993759
35	PHKG2	0.99993759
36	MAP2K7	0.98119416
37	FES	0.97885646
38	INSRR	0.97330288
39	MAP2K6	0.97113823
40	PAK3	0.95800111
41	CSNK1G2	0.86918450
42	MYLK	0.85449517
43	PRKCQ	0.84424221
44	CSNK1G3	0.83694330
45	BTK	0.80833257
46	MUSK	0.80108002
47	NME1	0.79451295
48	DAPK2	0.79111365
49	CAMK1	0.78356492
50	VRK2	0.78083643
51	CAMKK1	0.77909098
52	KDR	0.77689501
53	MAPK13	0.77571041
54	ADRBK1	0.72820115
55	CASK	0.72480100
56	CSF1R	0.71742672
57	PRKCG	0.71095740
58	LYN	0.69188188
59	RPS6KA5	0.69120025
60	VRK1	0.68527361
61	SYK	0.68263069
62	TNK2	0.68132418
63	CSNK1A1L	0.67166905
64	EIF2AK1	0.66712994
65	CSNK1G1	0.63308270
66	MAPKAPK3	0.59768961
67	LCK	0.59118130
68	EPHA4	0.57811428
69	FLT3	0.57593345
70	OBSCN	0.57458141
71	PRKCE	0.56982291
72	PRKACA	0.56754553
73	DAPK1	0.55663949
74	BCR	0.55052026
75	MAP3K11	0.54554495
76	NEK1	0.52944464
77	LIMK1	0.51860516
78	DAPK3	0.51540139
79	CSNK1A1	0.51341325
80	CAMK2A	0.48405555
81	EIF2AK3	0.46689134
82	MINK1	0.46448983
83	NTRK2	0.44194732
84	CSNK2A2	0.44083805
85	GRK7	0.42985479
86	ERBB3	0.42728522
87	CDK8	0.41833408
88	IGF1R	0.41611714
89	PRKCA	0.40574496
90	TYRO3	0.40161924
91	LRRK2	0.40022477
92	PIK3CG	0.38979660
93	MAPKAPK5	0.37280337
94	WNK1	0.35744600
95	TAF1	0.35625037
96	IKBKE	0.34612138
97	SRPK1	0.34559705
98	CSNK2A1	0.34151466
99	ATR	0.33596624
100	SCYL2	0.32535989

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.20785118
2	Ribosome_Homo sapiens_hsa03010	3.91553734
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.77698722
4	Allograft rejection_Homo sapiens_hsa05330	3.28518826
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.15883653
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.10748687
7	Protein export_Homo sapiens_hsa03060	3.03083171
8	Parkinsons disease_Homo sapiens_hsa05012	2.99977735
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.70634155
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.67299478
11	Proteasome_Homo sapiens_hsa03050	2.19134401
12	RNA polymerase_Homo sapiens_hsa03020	2.00999239
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.00755979
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.98343534
15	Alzheimers disease_Homo sapiens_hsa05010	1.96518499
16	Huntingtons disease_Homo sapiens_hsa05016	1.89456771
17	Phototransduction_Homo sapiens_hsa04744	1.85840263
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.83994476
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.72987611
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68658502
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.56279408
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.53388365
23	Primary immunodeficiency_Homo sapiens_hsa05340	1.52938004
24	RNA degradation_Homo sapiens_hsa03018	1.41971558
25	Antigen processing and presentation_Homo sapiens_hsa04612	1.39118327
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.36654370
27	Basal transcription factors_Homo sapiens_hsa03022	1.24347551
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.17896337
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13969139
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.11616542
31	Homologous recombination_Homo sapiens_hsa03440	1.11236041
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01868974
33	Viral myocarditis_Homo sapiens_hsa05416	1.01808923
34	One carbon pool by folate_Homo sapiens_hsa00670	0.97988418
35	Butanoate metabolism_Homo sapiens_hsa00650	0.92114893
36	Nucleotide excision repair_Homo sapiens_hsa03420	0.91782382
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.91638720
38	Peroxisome_Homo sapiens_hsa04146	0.89341757
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88978541
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.88944532
41	Regulation of autophagy_Homo sapiens_hsa04140	0.88410001
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.88295070
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.86178304
44	Nicotine addiction_Homo sapiens_hsa05033	0.86014529
45	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.84619524
46	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.83418398
47	Olfactory transduction_Homo sapiens_hsa04740	0.82983871
48	Propanoate metabolism_Homo sapiens_hsa00640	0.82916577
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81480932
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.80334702
51	Caffeine metabolism_Homo sapiens_hsa00232	0.77044013
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75864169
53	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.75774368
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.72788563
55	Morphine addiction_Homo sapiens_hsa05032	0.68334708
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.66227054
57	Purine metabolism_Homo sapiens_hsa00230	0.66025654
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65715999
59	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.65707957
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.64359927
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64333995
62	Fanconi anemia pathway_Homo sapiens_hsa03460	0.62400041
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58126920
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.58112490
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56136627
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55494212
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52224036
68	Retinol metabolism_Homo sapiens_hsa00830	0.52156246
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51780076
70	Metabolic pathways_Homo sapiens_hsa01100	0.51068797
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.50762788
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.50647740
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.46579281
74	RNA transport_Homo sapiens_hsa03013	0.46094485
75	GABAergic synapse_Homo sapiens_hsa04727	0.44868390
76	Insulin secretion_Homo sapiens_hsa04911	0.43234665
77	Mismatch repair_Homo sapiens_hsa03430	0.41161731
78	Leishmaniasis_Homo sapiens_hsa05140	0.40225293
79	Taste transduction_Homo sapiens_hsa04742	0.39880993
80	Spliceosome_Homo sapiens_hsa03040	0.38468101
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38124044
82	Serotonergic synapse_Homo sapiens_hsa04726	0.35661781
83	Steroid biosynthesis_Homo sapiens_hsa00100	0.33192645
84	Sulfur metabolism_Homo sapiens_hsa00920	0.32403525
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31523883
86	Salivary secretion_Homo sapiens_hsa04970	0.30626937
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30488092
88	Circadian entrainment_Homo sapiens_hsa04713	0.29221102
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.28852882
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.28523882
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28291888
92	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.26621638
93	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24956562
94	Sulfur relay system_Homo sapiens_hsa04122	0.23672614
95	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.22593514
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.22412443
97	Mineral absorption_Homo sapiens_hsa04978	0.22121890
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.21329375
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.21281828
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.18179542

RPL21P18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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