RPL21P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.04102604
2viral transcription (GO:0019083)4.90539134
3ATP synthesis coupled proton transport (GO:0015986)4.89327571
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.89327571
5DNA deamination (GO:0045006)4.85566924
6translational termination (GO:0006415)4.68387605
7ribosomal small subunit biogenesis (GO:0042274)4.54143682
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.49421031
9protein complex biogenesis (GO:0070271)4.47313465
10maturation of SSU-rRNA (GO:0030490)4.45179869
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.45174374
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.45159589
13cotranslational protein targeting to membrane (GO:0006613)4.41738904
14behavioral response to nicotine (GO:0035095)4.39716816
15protein targeting to ER (GO:0045047)4.38739169
16chaperone-mediated protein transport (GO:0072321)4.32576116
17protein neddylation (GO:0045116)4.30564414
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.23567811
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.23543929
20water-soluble vitamin biosynthetic process (GO:0042364)4.19581541
21GTP biosynthetic process (GO:0006183)4.15893357
22protein localization to endoplasmic reticulum (GO:0070972)4.13057193
23mitochondrial respiratory chain complex I assembly (GO:0032981)4.11191211
24NADH dehydrogenase complex assembly (GO:0010257)4.11191211
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.11191211
26translational elongation (GO:0006414)4.06838598
27mitochondrial respiratory chain complex assembly (GO:0033108)3.94418209
28ribosomal large subunit biogenesis (GO:0042273)3.75338804
29respiratory electron transport chain (GO:0022904)3.74301560
30electron transport chain (GO:0022900)3.74147458
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.74112208
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.69745464
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.69745464
34termination of RNA polymerase III transcription (GO:0006386)3.67972299
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.67972299
36viral life cycle (GO:0019058)3.61305717
37positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.58808142
38regulation of isotype switching to IgG isotypes (GO:0048302)3.51850244
39UTP biosynthetic process (GO:0006228)3.43784984
40cellular protein complex disassembly (GO:0043624)3.41744645
41translation (GO:0006412)3.38760668
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.35922575
43translational initiation (GO:0006413)3.32076545
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.28656079
45mannosylation (GO:0097502)3.26537711
46axoneme assembly (GO:0035082)3.25207263
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24851651
48respiratory chain complex IV assembly (GO:0008535)3.23532045
49purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.18109973
50purine nucleoside triphosphate biosynthetic process (GO:0009145)3.17036703
51peptidyl-histidine modification (GO:0018202)3.16514669
52regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.13560833
53kynurenine metabolic process (GO:0070189)3.11157921
54UTP metabolic process (GO:0046051)3.10962721
55cytochrome complex assembly (GO:0017004)3.09846803
56interferon-gamma production (GO:0032609)3.08756832
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.08093281
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00975947
59cellular component biogenesis (GO:0044085)2.98920720
60tryptophan catabolic process (GO:0006569)2.98320986
61indole-containing compound catabolic process (GO:0042436)2.98320986
62indolalkylamine catabolic process (GO:0046218)2.98320986
63hydrogen ion transmembrane transport (GO:1902600)2.97535054
64epithelial cilium movement (GO:0003351)2.90526871
65CTP metabolic process (GO:0046036)2.89943684
66CTP biosynthetic process (GO:0006241)2.89943684
67ATP biosynthetic process (GO:0006754)2.87231010
68protein targeting to membrane (GO:0006612)2.84838313
69proton transport (GO:0015992)2.83125104
70intracellular protein transmembrane import (GO:0044743)2.79527220
71regulation of immunoglobulin secretion (GO:0051023)2.79357380
72cytidine metabolic process (GO:0046087)2.78823110
73cytidine catabolic process (GO:0006216)2.78823110
74cytidine deamination (GO:0009972)2.78823110
75preassembly of GPI anchor in ER membrane (GO:0016254)2.77773212
76hydrogen transport (GO:0006818)2.75823840
77ribonucleoside triphosphate biosynthetic process (GO:0009201)2.73612598
78tRNA processing (GO:0008033)2.73072878
79indolalkylamine metabolic process (GO:0006586)2.72527032
80positive regulation of interleukin-17 production (GO:0032740)2.71254879
81platelet dense granule organization (GO:0060155)2.71119678
82proteasome assembly (GO:0043248)2.71001972
83rRNA processing (GO:0006364)2.70399056
84protein complex disassembly (GO:0043241)2.69343724
85rRNA metabolic process (GO:0016072)2.67337341
86piRNA metabolic process (GO:0034587)2.65294269
87macromolecular complex disassembly (GO:0032984)2.62680962
88ribonucleoprotein complex biogenesis (GO:0022613)2.60828256
89protein-cofactor linkage (GO:0018065)2.59741859
90nuclear-transcribed mRNA catabolic process (GO:0000956)2.59705012
91nucleoside diphosphate phosphorylation (GO:0006165)2.58807634
92rRNA modification (GO:0000154)2.58506616
93amine catabolic process (GO:0009310)2.57713418
94cellular biogenic amine catabolic process (GO:0042402)2.57713418
95fucose catabolic process (GO:0019317)2.57523194
96L-fucose metabolic process (GO:0042354)2.57523194
97L-fucose catabolic process (GO:0042355)2.57523194
98base-excision repair, AP site formation (GO:0006285)2.55640388
99cellular ketone body metabolic process (GO:0046950)2.55290658
100guanosine-containing compound biosynthetic process (GO:1901070)2.55073070

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.78241847
2VDR_22108803_ChIP-Seq_LS180_Human3.27665044
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19180388
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14929761
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06800495
6EZH2_22144423_ChIP-Seq_EOC_Human2.90620277
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.87556349
8ZNF274_21170338_ChIP-Seq_K562_Hela2.72329138
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.44078949
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42761387
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23320196
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21450335
13VDR_23849224_ChIP-Seq_CD4+_Human1.98473790
14MYC_18940864_ChIP-ChIP_HL60_Human1.92253305
15EWS_26573619_Chip-Seq_HEK293_Human1.91910860
16ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85996426
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85501413
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.85414774
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81102912
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72611649
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71485519
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.69991189
23TP53_22573176_ChIP-Seq_HFKS_Human1.69599744
24FOXP3_21729870_ChIP-Seq_TREG_Human1.66981589
25ELK1_19687146_ChIP-ChIP_HELA_Human1.66587890
26IRF1_19129219_ChIP-ChIP_H3396_Human1.58948311
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57231331
28MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53800009
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51346948
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50593924
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50553597
32FUS_26573619_Chip-Seq_HEK293_Human1.48691968
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.48367029
34IGF1R_20145208_ChIP-Seq_DFB_Human1.47634462
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46506487
36P300_19829295_ChIP-Seq_ESCs_Human1.46231161
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.42982004
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42982004
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42633002
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.42062031
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.41868040
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41554189
43ER_23166858_ChIP-Seq_MCF-7_Human1.36310418
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35125734
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34168061
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33731820
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31691515
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31328566
49NCOR_22424771_ChIP-Seq_293T_Human1.30340692
50CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.29325515
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.25930743
52REST_21632747_ChIP-Seq_MESCs_Mouse1.22293038
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21391245
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21153496
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.21131274
56SOX2_19829295_ChIP-Seq_ESCs_Human1.20023798
57NANOG_19829295_ChIP-Seq_ESCs_Human1.20023798
58TTF2_22483619_ChIP-Seq_HELA_Human1.19333976
59TAF2_19829295_ChIP-Seq_ESCs_Human1.17942272
60NANOG_20526341_ChIP-Seq_ESCs_Human1.16357433
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14589878
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13089165
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12758246
64CBP_20019798_ChIP-Seq_JUKART_Human1.12758246
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12614234
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11222817
67TAF15_26573619_Chip-Seq_HEK293_Human1.11153285
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09929976
69MYC_19829295_ChIP-Seq_ESCs_Human1.09215007
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08929146
71HOXB7_26014856_ChIP-Seq_BT474_Human1.08657418
72AR_20517297_ChIP-Seq_VCAP_Human1.08359604
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.07527055
74BCAT_22108803_ChIP-Seq_LS180_Human1.07287829
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06998624
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06577877
77RNF2_27304074_Chip-Seq_NSC_Mouse1.06422454
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.04105840
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03870714
80ERA_21632823_ChIP-Seq_H3396_Human1.03640180
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.02709593
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02641555
83GABP_19822575_ChIP-Seq_HepG2_Human1.01485843
84TCF4_22108803_ChIP-Seq_LS180_Human1.00681421
85JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00236107
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00178287
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.00003985
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99072850
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99021671
90P53_21459846_ChIP-Seq_SAOS-2_Human0.98778305
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.98211853
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97006788
93CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96166426
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95833368
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95381339
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93642618
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93642618
98GATA3_26560356_Chip-Seq_TH2_Human0.92938521
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92359868
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91189823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.54279165
2MP0003787_abnormal_imprinting3.49880745
3MP0009379_abnormal_foot_pigmentation2.83128514
4MP0008877_abnormal_DNA_methylation2.74859275
5MP0002163_abnormal_gland_morphology2.66972913
6MP0002102_abnormal_ear_morphology2.53207830
7MP0005671_abnormal_response_to2.25636326
8MP0002837_dystrophic_cardiac_calcinosis2.25071644
9MP0008875_abnormal_xenobiotic_pharmacok2.21280910
10MP0005379_endocrine/exocrine_gland_phen2.18922452
11MP0008872_abnormal_physiological_respon2.06959285
12MP0005645_abnormal_hypothalamus_physiol2.06927387
13MP0005084_abnormal_gallbladder_morpholo2.04908917
14MP0004142_abnormal_muscle_tone2.03988154
15MP0001348_abnormal_lacrimal_gland2.03578032
16MP0004145_abnormal_muscle_electrophysio1.95997026
17MP0004147_increased_porphyrin_level1.91906127
18MP0004885_abnormal_endolymph1.84163041
19MP0006072_abnormal_retinal_apoptosis1.81964532
20MP0005551_abnormal_eye_electrophysiolog1.81346624
21MP0005377_hearing/vestibular/ear_phenot1.78917471
22MP0003878_abnormal_ear_physiology1.78917471
23MP0001835_abnormal_antigen_presentation1.77532863
24MP0003646_muscle_fatigue1.76922575
25MP0002138_abnormal_hepatobiliary_system1.75423574
26MP0001968_abnormal_touch/_nociception1.73072083
27MP0002653_abnormal_ependyma_morphology1.68754106
28MP0006276_abnormal_autonomic_nervous1.66083193
29MP0002876_abnormal_thyroid_physiology1.65191192
30MP0005646_abnormal_pituitary_gland1.63300794
31MP0002272_abnormal_nervous_system1.58413974
32MP0002736_abnormal_nociception_after1.55546400
33MP0001984_abnormal_olfaction1.54002058
34MP0001986_abnormal_taste_sensitivity1.50539546
35MP0004742_abnormal_vestibular_system1.49607300
36MP0003880_abnormal_central_pattern1.47403594
37MP0002160_abnormal_reproductive_system1.45285235
38MP0009745_abnormal_behavioral_response1.36621482
39MP0001485_abnormal_pinna_reflex1.34243767
40MP0008789_abnormal_olfactory_epithelium1.29713309
41MP0002928_abnormal_bile_duct1.29654947
42MP0005253_abnormal_eye_physiology1.28203363
43MP0005389_reproductive_system_phenotype1.27427778
44MP0003195_calcinosis1.23961663
45MP0003121_genomic_imprinting1.21307255
46MP0003122_maternal_imprinting1.21162361
47MP0003011_delayed_dark_adaptation1.19721285
48MP0001905_abnormal_dopamine_level1.19317964
49MP0000631_abnormal_neuroendocrine_gland1.18179661
50MP0002184_abnormal_innervation1.17525321
51MP0001970_abnormal_pain_threshold1.14688510
52MP0002733_abnormal_thermal_nociception1.13694003
53MP0002638_abnormal_pupillary_reflex1.12979704
54MP0002557_abnormal_social/conspecific_i1.12558824
55MP0001440_abnormal_grooming_behavior1.12143312
56MP0002572_abnormal_emotion/affect_behav1.11146358
57MP0003123_paternal_imprinting1.10550295
58MP0001188_hyperpigmentation1.10240143
59MP0005423_abnormal_somatic_nervous1.07490139
60MP0001501_abnormal_sleep_pattern1.06934811
61MP0002735_abnormal_chemical_nociception1.06451487
62MP0000427_abnormal_hair_cycle1.04259573
63MP0001293_anophthalmia1.03569088
64MP0002938_white_spotting1.00672813
65MP0003890_abnormal_embryonic-extraembry0.99705918
66MP0004133_heterotaxia0.99586357
67MP0000569_abnormal_digit_pigmentation0.99281581
68MP0001529_abnormal_vocalization0.99264079
69MP0002234_abnormal_pharynx_morphology0.98472737
70MP0000049_abnormal_middle_ear0.97718620
71MP0001873_stomach_inflammation0.96162311
72MP0009046_muscle_twitch0.95509789
73MP0003635_abnormal_synaptic_transmissio0.92247762
74MP0010386_abnormal_urinary_bladder0.92088813
75MP0003567_abnormal_fetal_cardiomyocyte0.91966313
76MP0003186_abnormal_redox_activity0.89319216
77MP0001790_abnormal_immune_system0.88413920
78MP0005387_immune_system_phenotype0.88413920
79MP0002693_abnormal_pancreas_physiology0.87273923
80MP0002822_catalepsy0.87140747
81MP0002752_abnormal_somatic_nervous0.86193783
82MP0005499_abnormal_olfactory_system0.84202499
83MP0005394_taste/olfaction_phenotype0.84202499
84MP0008058_abnormal_DNA_repair0.83288615
85MP0000685_abnormal_immune_system0.82931843
86MP0000778_abnormal_nervous_system0.81822208
87MP0005195_abnormal_posterior_eye0.81734176
88MP0002095_abnormal_skin_pigmentation0.81471072
89MP0001486_abnormal_startle_reflex0.80717195
90MP0001800_abnormal_humoral_immune0.80659239
91MP0005075_abnormal_melanosome_morpholog0.79908183
92MP0002734_abnormal_mechanical_nocicepti0.79693345
93MP0002277_abnormal_respiratory_mucosa0.79687095
94MP0005636_abnormal_mineral_homeostasis0.78898186
95MP0001919_abnormal_reproductive_system0.77704326
96MP0002067_abnormal_sensory_capabilities0.76625702
97MP0002063_abnormal_learning/memory/cond0.76496395
98MP0001502_abnormal_circadian_rhythm0.75975703
99MP0006036_abnormal_mitochondrial_physio0.74034501
100MP0005410_abnormal_fertilization0.71603799

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.95755120
2Abnormal mitochondria in muscle tissue (HP:0008316)4.35419524
3Progressive macrocephaly (HP:0004481)4.21386351
4Acute encephalopathy (HP:0006846)4.18569126
5Mitochondrial inheritance (HP:0001427)4.08077592
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.89864970
7Increased CSF lactate (HP:0002490)3.75621226
8Pancreatic cysts (HP:0001737)3.70130815
9Hepatocellular necrosis (HP:0001404)3.57113834
10Pancreatic fibrosis (HP:0100732)3.56103277
11Increased hepatocellular lipid droplets (HP:0006565)3.52152607
12Molar tooth sign on MRI (HP:0002419)3.49920106
13Abnormality of midbrain morphology (HP:0002418)3.49920106
14Abnormal rod and cone electroretinograms (HP:0008323)3.46214176
15Lipid accumulation in hepatocytes (HP:0006561)3.33503612
16Hepatic necrosis (HP:0002605)3.29140572
17Reticulocytopenia (HP:0001896)3.22049574
18Cerebral edema (HP:0002181)3.08549839
193-Methylglutaconic aciduria (HP:0003535)3.04171097
20Congenital stationary night blindness (HP:0007642)3.03554692
21Methylmalonic acidemia (HP:0002912)3.02633056
22Nephronophthisis (HP:0000090)3.01680464
23Abnormality of cells of the erythroid lineage (HP:0012130)2.98200490
24Optic disc pallor (HP:0000543)2.98048905
25Renal Fanconi syndrome (HP:0001994)2.91936998
26Type II lissencephaly (HP:0007260)2.77237622
27Pendular nystagmus (HP:0012043)2.74465135
28Macrocytic anemia (HP:0001972)2.70729073
29True hermaphroditism (HP:0010459)2.69584294
30Stomatitis (HP:0010280)2.64711653
31Abnormality of the renal cortex (HP:0011035)2.60020813
32Constricted visual fields (HP:0001133)2.59937440
33Abnormality of the renal medulla (HP:0100957)2.55894950
34Methylmalonic aciduria (HP:0012120)2.53533744
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51691987
36Aplastic anemia (HP:0001915)2.51369683
37Leukodystrophy (HP:0002415)2.49432512
38Renal cortical cysts (HP:0000803)2.48681829
39Increased serum lactate (HP:0002151)2.47056423
40Medial flaring of the eyebrow (HP:0010747)2.39310351
41Increased intramyocellular lipid droplets (HP:0012240)2.39160767
42Abnormal number of erythroid precursors (HP:0012131)2.38515318
43Congenital, generalized hypertrichosis (HP:0004540)2.38270003
44Abolished electroretinogram (ERG) (HP:0000550)2.38077618
45Exertional dyspnea (HP:0002875)2.36748313
46Cystic liver disease (HP:0006706)2.32367596
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.28908981
48Absent/shortened dynein arms (HP:0200106)2.28908981
49Lethargy (HP:0001254)2.22078208
50IgG deficiency (HP:0004315)2.20674528
51Aplasia/Hypoplasia of the spleen (HP:0010451)2.20304238
52Abnormal ciliary motility (HP:0012262)2.18916575
53Hyperglycinemia (HP:0002154)2.15989622
54Asplenia (HP:0001746)2.11089438
55Colon cancer (HP:0003003)2.10634217
56Abnormality of renal resorption (HP:0011038)2.10603640
57Lactic acidosis (HP:0003128)2.09965167
58Abnormal drinking behavior (HP:0030082)2.09087388
59Polydipsia (HP:0001959)2.09087388
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08460437
61Respiratory failure (HP:0002878)2.07948627
62Abnormal respiratory epithelium morphology (HP:0012253)2.07031750
63Abnormal respiratory motile cilium morphology (HP:0005938)2.07031750
64Glycosuria (HP:0003076)2.04579699
65Abnormality of urine glucose concentration (HP:0011016)2.04579699
66Increased muscle lipid content (HP:0009058)1.98258464
67Attenuation of retinal blood vessels (HP:0007843)1.97625537
68Exercise intolerance (HP:0003546)1.96774777
69Abnormal respiratory motile cilium physiology (HP:0012261)1.94416056
70Myokymia (HP:0002411)1.90776836
71Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87551382
72Polyuria (HP:0000103)1.87118551
73Increased IgM level (HP:0003496)1.86844507
74Sclerocornea (HP:0000647)1.86632400
75Abnormal biliary tract physiology (HP:0012439)1.83801387
76Bile duct proliferation (HP:0001408)1.83801387
77Septo-optic dysplasia (HP:0100842)1.82767782
78Pallor (HP:0000980)1.81974157
79Congenital hepatic fibrosis (HP:0002612)1.80167851
80Pancytopenia (HP:0001876)1.79848109
81Progressive cerebellar ataxia (HP:0002073)1.78971557
82Thyroiditis (HP:0100646)1.78438413
83Stenosis of the external auditory canal (HP:0000402)1.76749602
84Decreased central vision (HP:0007663)1.76666179
85Gait imbalance (HP:0002141)1.76087073
86Median cleft lip (HP:0000161)1.75961041
87Tubular atrophy (HP:0000092)1.74950466
88Adrenal hypoplasia (HP:0000835)1.72751674
89Respiratory difficulties (HP:0002880)1.72317590
90Cerebral palsy (HP:0100021)1.72040317
91Supernumerary spleens (HP:0009799)1.70985333
92Congenital primary aphakia (HP:0007707)1.69747212
93Elevated erythrocyte sedimentation rate (HP:0003565)1.69746623
94CNS demyelination (HP:0007305)1.69338454
95Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.68892215
96Abnormality of vitamin B metabolism (HP:0004340)1.68837048
97X-linked dominant inheritance (HP:0001423)1.68640396
98Hypoplasia of the ulna (HP:0003022)1.67990598
99Bony spicule pigmentary retinopathy (HP:0007737)1.67065940
100Hyperphosphaturia (HP:0003109)1.66954261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.13410946
2WNK43.02677404
3STK162.83228964
4CDK192.77890911
5NUAK12.65591193
6ADRBK22.63817574
7GRK12.51700323
8MAP4K22.46486921
9VRK22.38468037
10TXK2.36886764
11BCKDK2.14600832
12PINK12.13258468
13ZAK2.05774753
14DYRK21.91117259
15OXSR11.73327104
16TAOK31.69300895
17NME11.62539355
18CAMKK21.52650869
19TIE11.52363886
20TLK11.52256156
21MAP3K121.50947455
22MST41.49872851
23MAP3K41.41873140
24WNK31.40708282
25PASK1.40542407
26MAP4K11.39006082
27PAK31.37914558
28TAF11.35541902
29TNK21.31947309
30STK391.31559739
31MAP2K61.31282105
32PRKCG1.24611164
33MAP2K71.23648077
34BMPR1B1.23278932
35VRK11.21452587
36TEC1.19205876
37ITK1.18807458
38NEK11.11872507
39INSRR1.06899177
40PRKCQ1.06321221
41PIK3CA1.03038409
42TRPM71.01170292
43SCYL20.92707619
44TRIM280.85790992
45FES0.85328518
46MKNK20.80997443
47IKBKB0.79771663
48PHKG10.75777431
49PHKG20.75777431
50BTK0.74558781
51KIT0.70702764
52ADRBK10.69390791
53EIF2AK10.68734779
54CAMK10.66869633
55RPS6KA50.66793799
56MAPK130.62928598
57PRKCE0.61912132
58CSNK1G10.59712969
59CSNK1G30.59539123
60PIK3CG0.58899063
61PLK30.58848424
62ACVR1B0.58729049
63TSSK60.57539827
64PRKACA0.57156103
65CSNK1G20.55672272
66CSNK2A20.54544896
67CAMK2A0.54172600
68MAP3K110.54107182
69WNK10.51782781
70PDK20.51388652
71NTRK20.50779224
72OBSCN0.47097004
73PRKCH0.46602979
74NME20.45706802
75CSNK1A1L0.45463204
76MINK10.45343440
77MKNK10.45264846
78STK110.44948266
79LCK0.44317421
80PRKG10.44212332
81CSNK1E0.42676022
82TNIK0.42479525
83PRKCA0.42150016
84PLK10.40467849
85PRKCD0.40041594
86PBK0.39151598
87FGFR20.37605638
88SYK0.37434465
89LRRK20.36058887
90DAPK10.35262294
91CAMKK10.34822654
92CSNK1A10.34766510
93SGK4940.34497462
94SGK2230.34497462
95PLK20.33997080
96TYRO30.33939024
97PRKCI0.33868639
98PRKCZ0.33653581
99CSNK2A10.33541374
100IGF1R0.32385227

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.33565535
2Oxidative phosphorylation_Homo sapiens_hsa001904.03202055
3Protein export_Homo sapiens_hsa030603.17664996
4Parkinsons disease_Homo sapiens_hsa050123.15755689
5Asthma_Homo sapiens_hsa053102.74470044
6RNA polymerase_Homo sapiens_hsa030202.58989911
7Allograft rejection_Homo sapiens_hsa053302.54012228
8Proteasome_Homo sapiens_hsa030502.34581641
9Autoimmune thyroid disease_Homo sapiens_hsa053202.21256650
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.11589049
11Cardiac muscle contraction_Homo sapiens_hsa042602.11275924
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10618229
13Alzheimers disease_Homo sapiens_hsa050102.08655729
14Type I diabetes mellitus_Homo sapiens_hsa049402.04248057
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01800411
16Huntingtons disease_Homo sapiens_hsa050162.01331080
17Phototransduction_Homo sapiens_hsa047442.01082570
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95878366
19Graft-versus-host disease_Homo sapiens_hsa053321.79490192
20Primary immunodeficiency_Homo sapiens_hsa053401.76041930
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60517785
22Linoleic acid metabolism_Homo sapiens_hsa005911.56027133
23Homologous recombination_Homo sapiens_hsa034401.45015785
24RNA degradation_Homo sapiens_hsa030181.43659201
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.43599667
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36648128
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34740183
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32658628
29One carbon pool by folate_Homo sapiens_hsa006701.32255174
30Basal transcription factors_Homo sapiens_hsa030221.24986155
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22597647
32Caffeine metabolism_Homo sapiens_hsa002321.18753821
33Propanoate metabolism_Homo sapiens_hsa006401.18707792
34Collecting duct acid secretion_Homo sapiens_hsa049661.16670557
35Butanoate metabolism_Homo sapiens_hsa006501.13284114
36Tryptophan metabolism_Homo sapiens_hsa003801.12737814
37Nitrogen metabolism_Homo sapiens_hsa009101.09669288
38Nicotine addiction_Homo sapiens_hsa050331.09553515
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09115077
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08832879
41Peroxisome_Homo sapiens_hsa041460.98369352
42Pyrimidine metabolism_Homo sapiens_hsa002400.96785378
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.94822021
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91620183
45Rheumatoid arthritis_Homo sapiens_hsa053230.88728387
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87493187
47Fanconi anemia pathway_Homo sapiens_hsa034600.86626183
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86222650
49Antigen processing and presentation_Homo sapiens_hsa046120.86219268
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79351532
51Taste transduction_Homo sapiens_hsa047420.78692055
52Retinol metabolism_Homo sapiens_hsa008300.78345692
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77886116
54Chemical carcinogenesis_Homo sapiens_hsa052040.77559221
55Hematopoietic cell lineage_Homo sapiens_hsa046400.77146643
56Olfactory transduction_Homo sapiens_hsa047400.76449970
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76323957
58Arachidonic acid metabolism_Homo sapiens_hsa005900.73152545
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72588303
60Purine metabolism_Homo sapiens_hsa002300.68577641
61Sulfur relay system_Homo sapiens_hsa041220.66410147
62Mismatch repair_Homo sapiens_hsa034300.66073552
63Nucleotide excision repair_Homo sapiens_hsa034200.65250264
64RNA transport_Homo sapiens_hsa030130.65103565
65Fat digestion and absorption_Homo sapiens_hsa049750.64440960
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62282668
67Metabolic pathways_Homo sapiens_hsa011000.61863621
68Steroid biosynthesis_Homo sapiens_hsa001000.61832175
69T cell receptor signaling pathway_Homo sapiens_hsa046600.60980857
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60827838
71Ether lipid metabolism_Homo sapiens_hsa005650.59670043
72Non-homologous end-joining_Homo sapiens_hsa034500.59477053
73Morphine addiction_Homo sapiens_hsa050320.56081773
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55538842
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.55152136
76Spliceosome_Homo sapiens_hsa030400.51542928
77Serotonergic synapse_Homo sapiens_hsa047260.48630948
78Regulation of autophagy_Homo sapiens_hsa041400.46469350
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45565356
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44016582
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42503003
82Insulin secretion_Homo sapiens_hsa049110.36609147
83GABAergic synapse_Homo sapiens_hsa047270.36337122
84Ovarian steroidogenesis_Homo sapiens_hsa049130.35316170
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35287864
86Folate biosynthesis_Homo sapiens_hsa007900.35189701
87Fatty acid degradation_Homo sapiens_hsa000710.34961479
88Glutamatergic synapse_Homo sapiens_hsa047240.33851587
89Pyruvate metabolism_Homo sapiens_hsa006200.32266174
90beta-Alanine metabolism_Homo sapiens_hsa004100.32259953
91Vitamin digestion and absorption_Homo sapiens_hsa049770.31080942
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30865919
93Mineral absorption_Homo sapiens_hsa049780.30813223
94Glutathione metabolism_Homo sapiens_hsa004800.29660922
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29491141
96Salivary secretion_Homo sapiens_hsa049700.25358834
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24033858
98Systemic lupus erythematosus_Homo sapiens_hsa053220.22250637
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.21338952
100Circadian entrainment_Homo sapiens_hsa047130.19847205

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »