ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	signal peptide processing (GO:0006465)	4.92203847
2	mannosylation (GO:0097502)	4.12387977
3	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.11397560
4	nonmotile primary cilium assembly (GO:0035058)	4.05913937
5	water-soluble vitamin biosynthetic process (GO:0042364)	3.98556154
6	ATP synthesis coupled proton transport (GO:0015986)	3.89665805
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.89665805
8	regulation of cilium movement (GO:0003352)	3.79603955
9	sphingoid metabolic process (GO:0046519)	3.77786807
10	ribosomal small subunit assembly (GO:0000028)	3.76381013
11	DNA deamination (GO:0045006)	3.76187310
12	cellular ketone body metabolic process (GO:0046950)	3.73535240
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.70854157
14	regulation of memory T cell differentiation (GO:0043380)	3.58014383
15	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.56803130
16	electron transport chain (GO:0022900)	3.55642743
17	respiratory electron transport chain (GO:0022904)	3.54948975
18	sphingosine metabolic process (GO:0006670)	3.47801206
19	response to pheromone (GO:0019236)	3.46780181
20	diol metabolic process (GO:0034311)	3.41585288
21	ketone body metabolic process (GO:1902224)	3.38008925
22	axoneme assembly (GO:0035082)	3.33485997
23	amine catabolic process (GO:0009310)	3.27137404
24	cellular biogenic amine catabolic process (GO:0042402)	3.27137404
25	behavioral response to nicotine (GO:0035095)	3.26505466
26	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.25966977
27	dopamine transport (GO:0015872)	3.22355229
28	regulation of immunoglobulin secretion (GO:0051023)	3.20727065
29	termination of RNA polymerase III transcription (GO:0006386)	3.19044966
30	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.19044966
31	protein complex biogenesis (GO:0070271)	3.15156705
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.13980980
33	NADH dehydrogenase complex assembly (GO:0010257)	3.13980980
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.13980980
35	indolalkylamine metabolic process (GO:0006586)	3.12872665
36	protein neddylation (GO:0045116)	3.11927346
37	artery smooth muscle contraction (GO:0014824)	3.10862060
38	indole-containing compound catabolic process (GO:0042436)	3.06736407
39	indolalkylamine catabolic process (GO:0046218)	3.06736407
40	tryptophan catabolic process (GO:0006569)	3.06736407
41	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.06484347
42	regulation of cellular respiration (GO:0043457)	3.06070731
43	hydrogen ion transmembrane transport (GO:1902600)	3.03743863
44	nitric oxide mediated signal transduction (GO:0007263)	3.01320387
45	proteasome assembly (GO:0043248)	3.00340357
46	regulation of protein glycosylation (GO:0060049)	2.98394758
47	proton transport (GO:0015992)	2.97814663
48	piRNA metabolic process (GO:0034587)	2.96500233
49	ovulation cycle (GO:0042698)	2.91728565
50	L-fucose catabolic process (GO:0042355)	2.91565278
51	fucose catabolic process (GO:0019317)	2.91565278
52	L-fucose metabolic process (GO:0042354)	2.91565278
53	hydrogen transport (GO:0006818)	2.91458050
54	kynurenine metabolic process (GO:0070189)	2.90791922
55	aldehyde catabolic process (GO:0046185)	2.89908352
56	DNA methylation involved in gamete generation (GO:0043046)	2.89495735
57	regulation of microtubule-based movement (GO:0060632)	2.88217023
58	mitochondrial respiratory chain complex assembly (GO:0033108)	2.84451284
59	rRNA catabolic process (GO:0016075)	2.82870517
60	photoreceptor cell maintenance (GO:0045494)	2.82449992
61	preassembly of GPI anchor in ER membrane (GO:0016254)	2.80968178
62	regulation of meiosis I (GO:0060631)	2.78203174
63	phagocytosis, recognition (GO:0006910)	2.73361718
64	xenobiotic catabolic process (GO:0042178)	2.72360559
65	platelet dense granule organization (GO:0060155)	2.71462264
66	negative regulation of appetite (GO:0032099)	2.69305297
67	negative regulation of response to food (GO:0032096)	2.69305297
68	lactate metabolic process (GO:0006089)	2.67351141
69	tryptophan metabolic process (GO:0006568)	2.66318831
70	tonic smooth muscle contraction (GO:0014820)	2.63128892
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.62385534
72	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.62385534
73	positive regulation of interleukin-17 production (GO:0032740)	2.61692173
74	positive regulation of T-helper 1 type immune response (GO:0002827)	2.61545809
75	protein prenylation (GO:0018342)	2.60274835
76	prenylation (GO:0097354)	2.60274835
77	respiratory chain complex IV assembly (GO:0008535)	2.54795723
78	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.54115908
79	GPI anchor metabolic process (GO:0006505)	2.53657659
80	multicellular organism reproduction (GO:0032504)	2.47219073
81	detection of light stimulus involved in sensory perception (GO:0050962)	2.45579650
82	detection of light stimulus involved in visual perception (GO:0050908)	2.45579650
83	positive regulation of meiosis (GO:0045836)	2.44022756
84	GPI anchor biosynthetic process (GO:0006506)	2.43646848
85	cellular response to leptin stimulus (GO:0044320)	2.42411747
86	GTP biosynthetic process (GO:0006183)	2.41005122
87	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.40276548
88	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.39557840
89	lipopolysaccharide biosynthetic process (GO:0009103)	2.39334696
90	ATP biosynthetic process (GO:0006754)	2.39100803
91	negative regulation of mast cell activation (GO:0033004)	2.38874250
92	positive regulation of T cell migration (GO:2000406)	2.38345878
93	regulation of appetite (GO:0032098)	2.38235275
94	protein localization to endoplasmic reticulum (GO:0070972)	2.36609149
95	protein targeting to ER (GO:0045047)	2.36337145
96	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.35498798
97	cotranslational protein targeting to membrane (GO:0006613)	2.35158784
98	reciprocal DNA recombination (GO:0035825)	2.35118274
99	reciprocal meiotic recombination (GO:0007131)	2.35118274
100	regulation of regulatory T cell differentiation (GO:0045589)	2.33372703

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.34520252
2	VDR_22108803_ChIP-Seq_LS180_Human	2.75687560
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.68535149
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.64013111
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.63906045
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.59652413
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.55649790
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.47068763
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25601771
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.09347873
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.09242611
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04510759
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.01354793
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00261855
15	P300_19829295_ChIP-Seq_ESCs_Human	1.97477565
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.94937206
17	EWS_26573619_Chip-Seq_HEK293_Human	1.93525066
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91709230
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.89795957
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.77520028
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.77344231
22	FUS_26573619_Chip-Seq_HEK293_Human	1.75453417
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.70000056
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.69462287
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67265543
26	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.64806031
27	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.63583136
28	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.63213376
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60998658
30	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.58637898
31	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.58637898
32	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.58249328
33	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.55380875
34	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.51309936
35	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.50963962
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49014980
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.48794656
38	TCF4_22108803_ChIP-Seq_LS180_Human	1.48595974
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47718121
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.47713595
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.47713595
42	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.42061267
43	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.41997203
44	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.41210580
45	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.40292067
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39977836
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.39977836
48	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.39969026
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.39211352
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36822200
51	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.36447154
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36312823
53	TCF4_23295773_ChIP-Seq_U87_Human	1.33510811
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32976161
55	VDR_23849224_ChIP-Seq_CD4+_Human	1.31940826
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31753628
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.31372483
58	STAT3_23295773_ChIP-Seq_U87_Human	1.29918887
59	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.29199683
60	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.29012548
61	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.28899741
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.26011252
63	CDX2_22108803_ChIP-Seq_LS180_Human	1.24963269
64	NCOR_22424771_ChIP-Seq_293T_Human	1.24182070
65	AR_25329375_ChIP-Seq_VCAP_Human	1.23619285
66	AR_21572438_ChIP-Seq_LNCaP_Human	1.21173919
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.16777453
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16693249
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16156628
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16028966
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15741864
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15707924
73	AR_20517297_ChIP-Seq_VCAP_Human	1.15183843
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.14644620
75	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.14557609
76	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13311518
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12219288
78	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.11269413
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10255825
80	FOXP3_21729870_ChIP-Seq_TREG_Human	1.10011117
81	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.09206138
82	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08930701
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08297950
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06130884
85	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.06097898
86	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05535990
87	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.05426284
88	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05002884
89	SMRT_27268052_Chip-Seq_Bcells_Human	1.04765736
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03729364
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03593666
92	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02898292
93	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02397865
94	TP53_16413492_ChIP-PET_HCT116_Human	1.00396173
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00203205
96	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00067201
97	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.99653681
98	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.99540400
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99217633
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.96934068

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.68229728
2	MP0000569_abnormal_digit_pigmentation	3.45750977
3	MP0005171_absent_coat_pigmentation	3.23095592
4	MP0009379_abnormal_foot_pigmentation	3.13429028
5	MP0001986_abnormal_taste_sensitivity	2.98193336
6	MP0003011_delayed_dark_adaptation	2.84556256
7	MP0003136_yellow_coat_color	2.77098716
8	MP0003646_muscle_fatigue	2.57378526
9	MP0008872_abnormal_physiological_respon	2.36952187
10	MP0000372_irregular_coat_pigmentation	2.34759478
11	MP0006072_abnormal_retinal_apoptosis	2.31128888
12	MP0001835_abnormal_antigen_presentation	2.30114306
13	MP0000427_abnormal_hair_cycle	2.16596980
14	MP0003195_calcinosis	2.16110407
15	MP0005551_abnormal_eye_electrophysiolog	2.13167337
16	MP0002653_abnormal_ependyma_morphology	2.11990268
17	MP0004147_increased_porphyrin_level	2.02785237
18	MP0002938_white_spotting	1.91832948
19	MP0001968_abnormal_touch/_nociception	1.79817311
20	MP0005075_abnormal_melanosome_morpholog	1.75754902
21	MP0001984_abnormal_olfaction	1.69776975
22	MP0005085_abnormal_gallbladder_physiolo	1.66716602
23	MP0002102_abnormal_ear_morphology	1.66365992
24	MP0005253_abnormal_eye_physiology	1.62529456
25	MP0008877_abnormal_DNA_methylation	1.61220550
26	MP0008875_abnormal_xenobiotic_pharmacok	1.58978513
27	MP0002736_abnormal_nociception_after	1.53965487
28	MP0005670_abnormal_white_adipose	1.53357909
29	MP0006292_abnormal_olfactory_placode	1.50532330
30	MP0004142_abnormal_muscle_tone	1.50200596
31	MP0003718_maternal_effect	1.47579669
32	MP0004019_abnormal_vitamin_homeostasis	1.46980799
33	MP0003186_abnormal_redox_activity	1.46785222
34	MP0001501_abnormal_sleep_pattern	1.42757897
35	MP0002095_abnormal_skin_pigmentation	1.40081331
36	MP0005174_abnormal_tail_pigmentation	1.40045624
37	MP0001485_abnormal_pinna_reflex	1.31761678
38	MP0005645_abnormal_hypothalamus_physiol	1.30678023
39	MP0008789_abnormal_olfactory_epithelium	1.30150186
40	MP0000383_abnormal_hair_follicle	1.28132245
41	MP0005389_reproductive_system_phenotype	1.24037432
42	MP0003806_abnormal_nucleotide_metabolis	1.23710141
43	MP0000013_abnormal_adipose_tissue	1.23689177
44	MP0009764_decreased_sensitivity_to	1.22974847
45	MP0009780_abnormal_chondrocyte_physiolo	1.20742962
46	MP0002272_abnormal_nervous_system	1.19988495
47	MP0002876_abnormal_thyroid_physiology	1.17351129
48	MP0004043_abnormal_pH_regulation	1.15301851
49	MP0002163_abnormal_gland_morphology	1.12980221
50	MP0005379_endocrine/exocrine_gland_phen	1.11774079
51	MP0008775_abnormal_heart_ventricle	1.11270457
52	MP0001440_abnormal_grooming_behavior	1.10117749
53	MP0002160_abnormal_reproductive_system	1.09685837
54	MP0000538_abnormal_urinary_bladder	1.07776535
55	MP0002638_abnormal_pupillary_reflex	1.07351335
56	MP0006036_abnormal_mitochondrial_physio	1.06791519
57	MP0001905_abnormal_dopamine_level	1.06771123
58	MP0001529_abnormal_vocalization	1.03922981
59	MP0004742_abnormal_vestibular_system	1.01679290
60	MP0000516_abnormal_urinary_system	1.01259643
61	MP0005367_renal/urinary_system_phenotyp	1.01259643
62	MP0005410_abnormal_fertilization	1.00441114
63	MP0001486_abnormal_startle_reflex	1.00000824
64	MP0009745_abnormal_behavioral_response	0.98383173
65	MP0003879_abnormal_hair_cell	0.98257044
66	MP0001790_abnormal_immune_system	0.96323526
67	MP0005387_immune_system_phenotype	0.96323526
68	MP0003183_abnormal_peptide_metabolism	0.96010703
69	MP0001970_abnormal_pain_threshold	0.93646261
70	MP0005365_abnormal_bile_salt	0.93216459
71	MP0002166_altered_tumor_susceptibility	0.91853958
72	MP0003880_abnormal_central_pattern	0.86991764
73	MP0004381_abnormal_hair_follicle	0.85054178
74	MP0010329_abnormal_lipoprotein_level	0.84918575
75	MP0005332_abnormal_amino_acid	0.83771742
76	MP0005423_abnormal_somatic_nervous	0.82766560
77	MP0002148_abnormal_hypersensitivity_rea	0.81843419
78	MP0005646_abnormal_pituitary_gland	0.78831389
79	MP0001756_abnormal_urination	0.78467467
80	MP0001853_heart_inflammation	0.78280983
81	MP0005408_hypopigmentation	0.76143904
82	MP0000230_abnormal_systemic_arterial	0.75855769
83	MP0002734_abnormal_mechanical_nocicepti	0.75450462
84	MP0005636_abnormal_mineral_homeostasis	0.74593546
85	MP0005671_abnormal_response_to	0.74145879
86	MP0000647_abnormal_sebaceous_gland	0.73282259
87	MP0002138_abnormal_hepatobiliary_system	0.72500744
88	MP0010386_abnormal_urinary_bladder	0.70951877
89	MP0002557_abnormal_social/conspecific_i	0.70020864
90	MP0003787_abnormal_imprinting	0.69726968
91	MP0002006_tumorigenesis	0.69512604
92	MP0004145_abnormal_muscle_electrophysio	0.68617637
93	MP0004885_abnormal_endolymph	0.68141006
94	MP0002229_neurodegeneration	0.65157796
95	MP0002572_abnormal_emotion/affect_behav	0.64296798
96	MP0001800_abnormal_humoral_immune	0.64188574
97	MP0001293_anophthalmia	0.63155338
98	MP0004215_abnormal_myocardial_fiber	0.63031953
99	MP0003252_abnormal_bile_duct	0.60982494
100	MP0002735_abnormal_chemical_nociception	0.60732216

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	4.68281104
2	Acute necrotizing encephalopathy (HP:0006965)	4.22552742
3	Type II lissencephaly (HP:0007260)	4.18332672
4	Cerebellar dysplasia (HP:0007033)	3.88959592
5	Hepatocellular necrosis (HP:0001404)	3.87749919
6	Acute encephalopathy (HP:0006846)	3.86157349
7	3-Methylglutaconic aciduria (HP:0003535)	3.79066285
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.78573378
9	Hepatic necrosis (HP:0002605)	3.78257422
10	Pancreatic cysts (HP:0001737)	3.63196291
11	Progressive macrocephaly (HP:0004481)	3.60550388
12	Mitochondrial inheritance (HP:0001427)	3.60162868
13	Increased CSF lactate (HP:0002490)	3.49241225
14	Abnormality of the renal cortex (HP:0011035)	3.24112228
15	Medial flaring of the eyebrow (HP:0010747)	2.99654074
16	Renal cortical cysts (HP:0000803)	2.98944800
17	Congenital stationary night blindness (HP:0007642)	2.91856228
18	Molar tooth sign on MRI (HP:0002419)	2.91289848
19	Abnormality of midbrain morphology (HP:0002418)	2.91289848
20	Methylmalonic aciduria (HP:0012120)	2.78021754
21	Aplasia/hypoplasia of the uterus (HP:0008684)	2.77180854
22	Hypoplasia of the uterus (HP:0000013)	2.70623454
23	Methylmalonic acidemia (HP:0002912)	2.63427594
24	Pancreatic fibrosis (HP:0100732)	2.60843540
25	Optic disc pallor (HP:0000543)	2.58863358
26	Pendular nystagmus (HP:0012043)	2.56167555
27	Stomatitis (HP:0010280)	2.50492550
28	Cerebral edema (HP:0002181)	2.48759587
29	Abolished electroretinogram (ERG) (HP:0000550)	2.48727771
30	True hermaphroditism (HP:0010459)	2.46015235
31	Hyperglycinemia (HP:0002154)	2.45336341
32	Nephronophthisis (HP:0000090)	2.44862560
33	IgG deficiency (HP:0004315)	2.41419725
34	Increased hepatocellular lipid droplets (HP:0006565)	2.40574600
35	Focal motor seizures (HP:0011153)	2.40058548
36	Increased IgM level (HP:0003496)	2.36752850
37	Disproportionate short-trunk short stature (HP:0003521)	2.35582605
38	Woolly hair (HP:0002224)	2.35398586
39	Hypothermia (HP:0002045)	2.33005222
40	Gait imbalance (HP:0002141)	2.32834127
41	Congenital primary aphakia (HP:0007707)	2.32512371
42	Parakeratosis (HP:0001036)	2.32216653
43	Lipid accumulation in hepatocytes (HP:0006561)	2.24066784
44	Abnormal rod and cone electroretinograms (HP:0008323)	2.21997625
45	Abnormality of the renal medulla (HP:0100957)	2.21001978
46	Amelogenesis imperfecta (HP:0000705)	2.19461383
47	Chronic diarrhea (HP:0002028)	2.18623649
48	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.16561979
49	Abnormality of alanine metabolism (HP:0010916)	2.16561979
50	Hyperalaninemia (HP:0003348)	2.16561979
51	Delayed CNS myelination (HP:0002188)	2.15045589
52	Renal Fanconi syndrome (HP:0001994)	2.12530358
53	Respiratory failure (HP:0002878)	2.12355090
54	Nephrogenic diabetes insipidus (HP:0009806)	2.11927291
55	Lethargy (HP:0001254)	2.11290716
56	Hypoplasia of the pons (HP:0012110)	2.07339752
57	Sclerocornea (HP:0000647)	2.07031323
58	Abnormality of vitamin B metabolism (HP:0004340)	2.06691056
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.06291181
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.06291181
61	Abnormality of urine glucose concentration (HP:0011016)	2.06263866
62	Glycosuria (HP:0003076)	2.06263866
63	Increased serum lactate (HP:0002151)	2.05759289
64	Dicarboxylic aciduria (HP:0003215)	2.05544988
65	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.05544988
66	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.04339582
67	Abnormality of serine family amino acid metabolism (HP:0010894)	2.03840168
68	Abnormality of glycine metabolism (HP:0010895)	2.03840168
69	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.03494842
70	Lactic acidosis (HP:0003128)	2.02522647
71	Leukodystrophy (HP:0002415)	2.01543075
72	Abnormality of the pons (HP:0007361)	2.00892556
73	Vaginal atresia (HP:0000148)	2.00534342
74	Abnormality of B cell number (HP:0010975)	1.99438431
75	Genital tract atresia (HP:0001827)	1.92419815
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.88681368
77	Abnormal drinking behavior (HP:0030082)	1.88638685
78	Polydipsia (HP:0001959)	1.88638685
79	Hyperventilation (HP:0002883)	1.88535322
80	Hyperglycinuria (HP:0003108)	1.88039107
81	Multiple enchondromatosis (HP:0005701)	1.87237600
82	Severe muscular hypotonia (HP:0006829)	1.87198943
83	Cystic liver disease (HP:0006706)	1.86588873
84	Keratoconus (HP:0000563)	1.85592705
85	Increased corneal curvature (HP:0100692)	1.85592705
86	Increased intramyocellular lipid droplets (HP:0012240)	1.85570828
87	Gaze-evoked nystagmus (HP:0000640)	1.84927617
88	Ketosis (HP:0001946)	1.84732764
89	Colon cancer (HP:0003003)	1.83614645
90	Elevated erythrocyte sedimentation rate (HP:0003565)	1.83429955
91	Abnormal biliary tract physiology (HP:0012439)	1.83112019
92	Bile duct proliferation (HP:0001408)	1.83112019
93	Optic nerve hypoplasia (HP:0000609)	1.80759303
94	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.78872156
95	CNS demyelination (HP:0007305)	1.78491569
96	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.76775650
97	Hemiparesis (HP:0001269)	1.76603143
98	Ketoacidosis (HP:0001993)	1.76357958
99	Synostosis of carpal bones (HP:0005048)	1.76071180
100	Anterior segment dysgenesis (HP:0007700)	1.76028734

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.74841210
2	PDK2	4.44458042
3	ZAK	2.88270087
4	BMPR1B	2.66812014
5	ADRBK2	2.62162996
6	LATS1	2.37221319
7	TXK	2.21889887
8	WNK4	2.12580892
9	NUAK1	2.10013962
10	STK38L	2.06412778
11	ACVR1B	1.88122634
12	STK16	1.87220677
13	GRK1	1.81611641
14	MST4	1.78439084
15	TAOK3	1.72413227
16	STK39	1.54013117
17	MKNK1	1.53604670
18	VRK2	1.47385263
19	WNK3	1.46296519
20	FLT3	1.37200757
21	CAMKK2	1.35552714
22	MKNK2	1.34177076
23	PINK1	1.34105070
24	MAP4K1	1.32101185
25	BMPR2	1.30426164
26	STK3	1.28260178
27	TLK1	1.23268525
28	PLK2	1.20027332
29	PAK3	1.14146858
30	NLK	1.13214007
31	ERBB4	1.12661092
32	PIK3CA	1.12196340
33	OXSR1	1.08152782
34	MAPKAPK5	1.07265929
35	MAP4K2	1.07001908
36	TEC	1.00698335
37	ADRBK1	0.99796079
38	TIE1	0.92975216
39	SCYL2	0.92570228
40	PRKCE	0.88427775
41	TNIK	0.87304351
42	MAP3K12	0.86768280
43	VRK1	0.84940654
44	INSRR	0.84811162
45	NEK6	0.83672493
46	PKN1	0.82079508
47	KIT	0.80758015
48	IKBKB	0.79044873
49	CSNK1G1	0.78672654
50	PRKAA2	0.78214850
51	CSNK1G2	0.78150889
52	MAP2K2	0.77777440
53	PHKG2	0.77359147
54	PHKG1	0.77359147
55	AKT3	0.75195731
56	RPS6KA5	0.74325196
57	PLK3	0.72740828
58	BRSK2	0.72402252
59	ITK	0.71271593
60	CSNK1G3	0.70198883
61	PTK2B	0.69015013
62	TGFBR1	0.67826424
63	MAP3K4	0.67728350
64	GRK7	0.66886089
65	MYLK	0.64958816
66	CSNK1A1L	0.64806599
67	MAPK13	0.63575652
68	ERBB3	0.62158234
69	TAF1	0.60068121
70	PRKCQ	0.57661233
71	DYRK2	0.56673885
72	PRKD3	0.56110796
73	TRPM7	0.55584742
74	NEK9	0.54636805
75	EIF2AK1	0.51493213
76	PRKCG	0.49897176
77	PBK	0.49697647
78	GRK5	0.49010451
79	EIF2AK3	0.48216179
80	PRKACA	0.47522050
81	PIK3CG	0.45770412
82	CAMK1	0.44573940
83	NEK1	0.44548744
84	TNK2	0.43783366
85	CSNK1D	0.42581648
86	CDK8	0.41200796
87	CSNK2A2	0.40320705
88	LYN	0.40173198
89	OBSCN	0.39609065
90	CAMK2A	0.39588834
91	MAPK11	0.39221104
92	CSNK1A1	0.38842034
93	SYK	0.37906932
94	CSF1R	0.34816070
95	CDK3	0.34609217
96	FES	0.34017093
97	PRKCA	0.33990290
98	CSNK2A1	0.33356686
99	BTK	0.31746579
100	MAPK7	0.31123642

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.37508913
2	Asthma_Homo sapiens_hsa05310	3.09549973
3	Protein export_Homo sapiens_hsa03060	2.66647101
4	Parkinsons disease_Homo sapiens_hsa05012	2.63756886
5	Proteasome_Homo sapiens_hsa03050	2.48244474
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.43730255
7	Allograft rejection_Homo sapiens_hsa05330	2.29468725
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.23197700
9	Ribosome_Homo sapiens_hsa03010	2.10144067
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.01981436
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.01283595
12	RNA polymerase_Homo sapiens_hsa03020	1.99350883
13	Homologous recombination_Homo sapiens_hsa03440	1.87752969
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.81053859
15	Alzheimers disease_Homo sapiens_hsa05010	1.75428675
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.74248424
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.73578673
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.72888010
19	Phototransduction_Homo sapiens_hsa04744	1.72417941
20	Propanoate metabolism_Homo sapiens_hsa00640	1.72175851
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.68136640
22	Huntingtons disease_Homo sapiens_hsa05016	1.65131413
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.63720071
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59934567
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.52501317
26	Caffeine metabolism_Homo sapiens_hsa00232	1.52187594
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.48423112
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.45669084
29	Butanoate metabolism_Homo sapiens_hsa00650	1.42482302
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.42137643
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.31302881
32	Sulfur metabolism_Homo sapiens_hsa00920	1.31186435
33	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.29736156
34	Basal transcription factors_Homo sapiens_hsa03022	1.28152666
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.27698904
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25324619
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.22482329
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20972215
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.20130251
40	Fat digestion and absorption_Homo sapiens_hsa04975	1.19261843
41	One carbon pool by folate_Homo sapiens_hsa00670	1.16859089
42	Rheumatoid arthritis_Homo sapiens_hsa05323	1.14514691
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13249863
44	Peroxisome_Homo sapiens_hsa04146	1.11591664
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10042405
46	RNA degradation_Homo sapiens_hsa03018	1.08314946
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.07405678
48	Nicotine addiction_Homo sapiens_hsa05033	1.02751244
49	Primary immunodeficiency_Homo sapiens_hsa05340	1.01712522
50	Ether lipid metabolism_Homo sapiens_hsa00565	1.01128417
51	Retinol metabolism_Homo sapiens_hsa00830	0.95868474
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.92604479
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90668698
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.86955234
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86399216
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83913837
57	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.80117976
58	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78545189
59	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.77879472
60	Fatty acid elongation_Homo sapiens_hsa00062	0.77023708
61	ABC transporters_Homo sapiens_hsa02010	0.76999161
62	Olfactory transduction_Homo sapiens_hsa04740	0.76376220
63	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75811645
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73512686
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71057398
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68867547
67	Metabolic pathways_Homo sapiens_hsa01100	0.68448390
68	Sphingolipid metabolism_Homo sapiens_hsa00600	0.68429710
69	Fatty acid degradation_Homo sapiens_hsa00071	0.68092826
70	Purine metabolism_Homo sapiens_hsa00230	0.67917877
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.67534560
72	Taste transduction_Homo sapiens_hsa04742	0.66276827
73	Mineral absorption_Homo sapiens_hsa04978	0.65615527
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64002273
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63672159
76	Antigen processing and presentation_Homo sapiens_hsa04612	0.63540940
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62166825
78	Nucleotide excision repair_Homo sapiens_hsa03420	0.60821282
79	Fanconi anemia pathway_Homo sapiens_hsa03460	0.57857059
80	Mismatch repair_Homo sapiens_hsa03430	0.57395056
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56899414
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55185285
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54174908
84	Histidine metabolism_Homo sapiens_hsa00340	0.54079254
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.53892523
86	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53542051
87	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.50092939
88	Viral myocarditis_Homo sapiens_hsa05416	0.48389262
89	Morphine addiction_Homo sapiens_hsa05032	0.48382219
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.46874410
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45112561
92	Salivary secretion_Homo sapiens_hsa04970	0.43200353
93	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.41024462
94	Regulation of autophagy_Homo sapiens_hsa04140	0.40365173
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39851278
96	Insulin secretion_Homo sapiens_hsa04911	0.39800066
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39370653
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.39111975
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35947058
100	PPAR signaling pathway_Homo sapiens_hsa03320	0.35294328

RPL21P23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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