ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.07953453
2	translational termination (GO:0006415)	7.75499858
3	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.53118151
4	ribosomal small subunit biogenesis (GO:0042274)	6.50320371
5	cotranslational protein targeting to membrane (GO:0006613)	6.41912369
6	protein targeting to ER (GO:0045047)	6.40994777
7	translational elongation (GO:0006414)	6.40467033
8	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.20422969
9	behavioral response to nicotine (GO:0035095)	6.15402634
10	protein localization to endoplasmic reticulum (GO:0070972)	5.96523717
11	cellular protein complex disassembly (GO:0043624)	5.94854608
12	ribosomal small subunit assembly (GO:0000028)	5.89013714
13	maturation of SSU-rRNA (GO:0030490)	5.72165730
14	viral life cycle (GO:0019058)	5.51731621
15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.46946773
16	protein complex disassembly (GO:0043241)	5.14516749
17	macromolecular complex disassembly (GO:0032984)	4.89303250
18	nonmotile primary cilium assembly (GO:0035058)	4.86157435
19	translational initiation (GO:0006413)	4.62885464
20	ncRNA catabolic process (GO:0034661)	4.52116254
21	glyoxylate metabolic process (GO:0046487)	4.33621911
22	protein targeting to membrane (GO:0006612)	4.33537033
23	left/right axis specification (GO:0070986)	4.23723249
24	chaperone-mediated protein transport (GO:0072321)	4.11109228
25	protein neddylation (GO:0045116)	3.98473548
26	cell proliferation in forebrain (GO:0021846)	3.97884552
27	rRNA catabolic process (GO:0016075)	3.97532411
28	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.94293261
29	aldehyde catabolic process (GO:0046185)	3.88309369
30	retina layer formation (GO:0010842)	3.79597437
31	central nervous system myelination (GO:0022010)	3.78873829
32	axon ensheathment in central nervous system (GO:0032291)	3.78873829
33	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.76827574
34	nucleoside diphosphate catabolic process (GO:0009134)	3.72836763
35	behavioral response to ethanol (GO:0048149)	3.70171561
36	mRNA catabolic process (GO:0006402)	3.68457370
37	opioid receptor signaling pathway (GO:0038003)	3.66379728
38	positive regulation of guanylate cyclase activity (GO:0031284)	3.64037584
39	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.46403476
40	substrate-independent telencephalic tangential migration (GO:0021826)	3.46403476
41	pyrimidine nucleobase catabolic process (GO:0006208)	3.43800221
42	lens fiber cell development (GO:0070307)	3.41948742
43	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.40395285
44	negative regulation of mast cell activation (GO:0033004)	3.37167478
45	RNA catabolic process (GO:0006401)	3.36075695
46	primitive streak formation (GO:0090009)	3.35682724
47	somite development (GO:0061053)	3.35009708
48	neuron fate determination (GO:0048664)	3.33740367
49	regulation of guanylate cyclase activity (GO:0031282)	3.29012851
50	translation (GO:0006412)	3.25914505
51	lateral sprouting from an epithelium (GO:0060601)	3.20056001
52	water-soluble vitamin biosynthetic process (GO:0042364)	3.17749959
53	positive regulation of gastrulation (GO:2000543)	3.14606307
54	synaptic transmission, cholinergic (GO:0007271)	3.14345286
55	positive regulation of cAMP-mediated signaling (GO:0043950)	3.04161840
56	regulation of collateral sprouting (GO:0048670)	2.94137202
57	negative regulation of cAMP-mediated signaling (GO:0043951)	2.93882245
58	limb development (GO:0060173)	2.92791559
59	appendage development (GO:0048736)	2.92791559
60	establishment of protein localization to membrane (GO:0090150)	2.90245829
61	histone-serine phosphorylation (GO:0035404)	2.88640524
62	axonemal dynein complex assembly (GO:0070286)	2.87237402
63	heart looping (GO:0001947)	2.86323855
64	ribosomal large subunit biogenesis (GO:0042273)	2.86211124
65	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.85537720
66	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.84000074
67	genetic imprinting (GO:0071514)	2.82159270
68	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.81508435
69	negative regulation of astrocyte differentiation (GO:0048712)	2.81039131
70	nucleobase catabolic process (GO:0046113)	2.80877523
71	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.79731371
72	NADH dehydrogenase complex assembly (GO:0010257)	2.79731371
73	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.79731371
74	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.76019427
75	ATP synthesis coupled proton transport (GO:0015986)	2.76019427
76	chromatin remodeling at centromere (GO:0031055)	2.75589258
77	regulation of cGMP metabolic process (GO:0030823)	2.67392681
78	auditory receptor cell differentiation (GO:0042491)	2.66970669
79	replication fork processing (GO:0031297)	2.66359141
80	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.60945440
81	negative regulation of multicellular organism growth (GO:0040015)	2.60620044
82	positive regulation of meiosis (GO:0045836)	2.60245501
83	tongue development (GO:0043586)	2.56095773
84	purine deoxyribonucleotide catabolic process (GO:0009155)	2.55607020
85	positive regulation of cGMP metabolic process (GO:0030825)	2.55139944
86	protein targeting (GO:0006605)	2.55121781
87	chromatin assembly (GO:0031497)	2.54894054
88	indolalkylamine metabolic process (GO:0006586)	2.54845422
89	protein complex biogenesis (GO:0070271)	2.53572021
90	establishment of protein localization to organelle (GO:0072594)	2.52984609
91	piRNA metabolic process (GO:0034587)	2.52657559
92	mechanosensory behavior (GO:0007638)	2.51585233
93	rhodopsin mediated signaling pathway (GO:0016056)	2.51245698
94	forebrain neuron differentiation (GO:0021879)	2.48551817
95	smoothened signaling pathway (GO:0007224)	2.48042883
96	regulation of gene expression by genetic imprinting (GO:0006349)	2.46777278
97	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.44419068
98	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.44333732
99	regulation of microtubule-based movement (GO:0060632)	2.43245685
100	response to redox state (GO:0051775)	2.41681791

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.37905772
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.79579175
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.89450699
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.73279086
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.72177986
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.36505246
7	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.34582305
8	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.24021165
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.13872798
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.13644105
11	VDR_22108803_ChIP-Seq_LS180_Human	2.08530745
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.05885384
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.95746601
14	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.90891837
15	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.87784567
16	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.74736709
17	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.74736709
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.74527351
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74431553
20	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.73405936
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.71771485
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71538172
23	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.66468114
24	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.63867214
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.63586122
26	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.63108071
27	FUS_26573619_Chip-Seq_HEK293_Human	1.58081719
28	DROSHA_22980978_ChIP-Seq_HELA_Human	1.58072593
29	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.56505202
30	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.56505202
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.56056144
32	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.53229429
33	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.52019391
34	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.51278259
35	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.50276131
36	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.49641754
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48007599
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41024286
39	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.40066674
40	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.39489362
41	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.39157381
42	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.37738354
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.35935161
44	P300_19829295_ChIP-Seq_ESCs_Human	1.31942155
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30259793
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.29703946
47	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.28118049
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27637410
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26565027
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.26565027
51	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.25680268
52	IGF1R_20145208_ChIP-Seq_DFB_Human	1.24694933
53	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.23876168
54	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23066139
55	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.22180060
56	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.21505846
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.21253199
58	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.21230565
59	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.19941929
60	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17907807
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16615688
62	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.16470073
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15900393
64	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.15569318
65	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14924071
66	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.14712304
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14248951
68	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13576669
69	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11254010
70	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.10164702
71	EWS_26573619_Chip-Seq_HEK293_Human	1.09912113
72	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.09385309
73	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.09181196
74	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.08094833
75	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.07319389
76	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06724841
77	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06473534
78	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06450052
79	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.05634870
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05519354
81	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.04997202
82	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.04725334
83	TAF15_26573619_Chip-Seq_HEK293_Human	1.04026215
84	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03848948
85	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.03148111
86	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.02065212
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01327118
88	BCAT_22108803_ChIP-Seq_LS180_Human	1.00192110
89	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.99641602
90	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.99351574
91	RXR_22108803_ChIP-Seq_LS180_Human	0.97820619
92	CEBPB_22108803_ChIP-Seq_LS180_Human	0.97724518
93	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95397923
94	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95397923
95	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94022532
96	TCF4_23295773_ChIP-Seq_U87_Human	0.93582208
97	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.93324028
98	STAT3_23295773_ChIP-Seq_U87_Human	0.93218315
99	HTT_18923047_ChIP-ChIP_STHdh_Human	0.92996704
100	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.92510194

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.84381690
2	MP0003136_yellow_coat_color	4.81330097
3	MP0006292_abnormal_olfactory_placode	4.56600666
4	MP0000566_synostosis	3.14843672
5	MP0009780_abnormal_chondrocyte_physiolo	2.91543283
6	MP0005451_abnormal_body_composition	2.86162652
7	MP0002638_abnormal_pupillary_reflex	2.71015128
8	MP0003646_muscle_fatigue	2.54499429
9	MP0008877_abnormal_DNA_methylation	2.43371559
10	MP0006072_abnormal_retinal_apoptosis	2.42572251
11	MP0001968_abnormal_touch/_nociception	2.37405885
12	MP0003787_abnormal_imprinting	1.96356463
13	MP0000049_abnormal_middle_ear	1.90600107
14	MP0001293_anophthalmia	1.77831685
15	MP0003122_maternal_imprinting	1.76765318
16	MP0006276_abnormal_autonomic_nervous	1.70314431
17	MP0008789_abnormal_olfactory_epithelium	1.69999317
18	MP0003880_abnormal_central_pattern	1.67899978
19	MP0001485_abnormal_pinna_reflex	1.66157440
20	MP0010030_abnormal_orbit_morphology	1.60692103
21	MP0002736_abnormal_nociception_after	1.58684012
22	MP0009384_cardiac_valve_regurgitation	1.53932699
23	MP0004142_abnormal_muscle_tone	1.53169935
24	MP0005645_abnormal_hypothalamus_physiol	1.52353042
25	MP0005253_abnormal_eye_physiology	1.48311786
26	MP0005551_abnormal_eye_electrophysiolog	1.48060916
27	MP0002938_white_spotting	1.46934431
28	MP0003123_paternal_imprinting	1.43890997
29	MP0003878_abnormal_ear_physiology	1.43449387
30	MP0005377_hearing/vestibular/ear_phenot	1.43449387
31	MP0004885_abnormal_endolymph	1.42762839
32	MP0001299_abnormal_eye_distance/	1.42654037
33	MP0002557_abnormal_social/conspecific_i	1.41466363
34	MP0001486_abnormal_startle_reflex	1.38746032
35	MP0003011_delayed_dark_adaptation	1.37024317
36	MP0004742_abnormal_vestibular_system	1.32636524
37	MP0002272_abnormal_nervous_system	1.32415189
38	MP0003121_genomic_imprinting	1.31801735
39	MP0001984_abnormal_olfaction	1.29673911
40	MP0005499_abnormal_olfactory_system	1.29315480
41	MP0005394_taste/olfaction_phenotype	1.29315480
42	MP0000631_abnormal_neuroendocrine_gland	1.26859823
43	MP0008872_abnormal_physiological_respon	1.26297577
44	MP0005646_abnormal_pituitary_gland	1.26278564
45	MP0005195_abnormal_posterior_eye	1.25061573
46	MP0003890_abnormal_embryonic-extraembry	1.22072452
47	MP0002733_abnormal_thermal_nociception	1.20527423
48	MP0001970_abnormal_pain_threshold	1.18843165
49	MP0009745_abnormal_behavioral_response	1.17735241
50	MP0000778_abnormal_nervous_system	1.17713459
51	MP0002735_abnormal_chemical_nociception	1.16608368
52	MP0010386_abnormal_urinary_bladder	1.15790024
53	MP0005670_abnormal_white_adipose	1.15079934
54	MP0001440_abnormal_grooming_behavior	1.12043491
55	MP0003119_abnormal_digestive_system	1.11876917
56	MP0004130_abnormal_muscle_cell	1.08480084
57	MP0002837_dystrophic_cardiac_calcinosis	1.08117902
58	MP0002876_abnormal_thyroid_physiology	1.07598377
59	MP0001188_hyperpigmentation	1.06348780
60	MP0002064_seizures	1.04158185
61	MP0001501_abnormal_sleep_pattern	1.02247766
62	MP0003385_abnormal_body_wall	1.02055553
63	MP0002572_abnormal_emotion/affect_behav	1.00804075
64	MP0001286_abnormal_eye_development	1.00260775
65	MP0005084_abnormal_gallbladder_morpholo	0.98116246
66	MP0002234_abnormal_pharynx_morphology	0.97261509
67	MP0002063_abnormal_learning/memory/cond	0.97188177
68	MP0004381_abnormal_hair_follicle	0.97141323
69	MP0000026_abnormal_inner_ear	0.95985020
70	MP0002932_abnormal_joint_morphology	0.95289282
71	MP0002160_abnormal_reproductive_system	0.94947123
72	MP0002752_abnormal_somatic_nervous	0.94688695
73	MP0002249_abnormal_larynx_morphology	0.94426448
74	MP0003183_abnormal_peptide_metabolism	0.93979687
75	MP0002102_abnormal_ear_morphology	0.93842350
76	MP0002067_abnormal_sensory_capabilities	0.92352925
77	MP0005423_abnormal_somatic_nervous	0.92284462
78	MP0003938_abnormal_ear_development	0.90501619
79	MP0004133_heterotaxia	0.89057942
80	MP0005391_vision/eye_phenotype	0.88243633
81	MP0003937_abnormal_limbs/digits/tail_de	0.87875484
82	MP0001529_abnormal_vocalization	0.87401815
83	MP0000955_abnormal_spinal_cord	0.86617143
84	MP0005389_reproductive_system_phenotype	0.86268085
85	MP0008058_abnormal_DNA_repair	0.84239179
86	MP0009053_abnormal_anal_canal	0.83433094
87	MP0003635_abnormal_synaptic_transmissio	0.82918394
88	MP0002734_abnormal_mechanical_nocicepti	0.81576010
89	MP0003755_abnormal_palate_morphology	0.80364296
90	MP0001963_abnormal_hearing_physiology	0.79902430
91	MP0002210_abnormal_sex_determination	0.78657070
92	MP0003567_abnormal_fetal_cardiomyocyte	0.77481590
93	MP0002184_abnormal_innervation	0.77480179
94	MP0000647_abnormal_sebaceous_gland	0.74805873
95	MP0001919_abnormal_reproductive_system	0.73326716
96	MP0002697_abnormal_eye_size	0.71969076
97	MP0003861_abnormal_nervous_system	0.71785321
98	MP0000750_abnormal_muscle_regeneration	0.70290560
99	MP0003638_abnormal_response/metabolism_	0.68827057
100	MP0002882_abnormal_neuron_morphology	0.67710121

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	5.21727532
2	Cerebellar dysplasia (HP:0007033)	4.83332611
3	Reticulocytopenia (HP:0001896)	4.68365009
4	Hyperventilation (HP:0002883)	4.10528641
5	Concave nail (HP:0001598)	3.63974931
6	Methylmalonic acidemia (HP:0002912)	3.42208575
7	Methylmalonic aciduria (HP:0012120)	3.25559074
8	Lissencephaly (HP:0001339)	3.14288183
9	Congenital, generalized hypertrichosis (HP:0004540)	3.03867952
10	Macrocytic anemia (HP:0001972)	3.02713103
11	Severe muscular hypotonia (HP:0006829)	2.97675107
12	Abnormality of cells of the erythroid lineage (HP:0012130)	2.93990174
13	Abnormal rod and cone electroretinograms (HP:0008323)	2.92431756
14	Hyperglycinemia (HP:0002154)	2.86683482
15	Abnormality of the pons (HP:0007361)	2.86483332
16	Poor head control (HP:0002421)	2.84582918
17	Thyroid-stimulating hormone excess (HP:0002925)	2.81315456
18	Epileptic encephalopathy (HP:0200134)	2.72000473
19	Asplenia (HP:0001746)	2.68788030
20	Abnormality of midbrain morphology (HP:0002418)	2.64784825
21	Molar tooth sign on MRI (HP:0002419)	2.64784825
22	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.63207404
23	Pallor (HP:0000980)	2.62281559
24	Horseshoe kidney (HP:0000085)	2.60167877
25	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.58894121
26	Pachygyria (HP:0001302)	2.55041883
27	Hypoplasia of the radius (HP:0002984)	2.54793348
28	Septo-optic dysplasia (HP:0100842)	2.52736502
29	Anterior segment dysgenesis (HP:0007700)	2.47482337
30	Abnormal hemoglobin (HP:0011902)	2.37783579
31	Oligodactyly (hands) (HP:0001180)	2.33985148
32	Impulsivity (HP:0100710)	2.30194738
33	Stenosis of the external auditory canal (HP:0000402)	2.29896377
34	Conical tooth (HP:0000698)	2.28238184
35	Nephronophthisis (HP:0000090)	2.27529998
36	Congenital stationary night blindness (HP:0007642)	2.27156506
37	Ectopic kidney (HP:0000086)	2.26723688
38	Partial agenesis of the corpus callosum (HP:0001338)	2.26524041
39	Abnormality of the renal collecting system (HP:0004742)	2.25800878
40	Duplicated collecting system (HP:0000081)	2.25064694
41	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.23445327
42	Short 4th metacarpal (HP:0010044)	2.21172337
43	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.21172337
44	Absent septum pellucidum (HP:0001331)	2.20000422
45	Agitation (HP:0000713)	2.17096333
46	Small hand (HP:0200055)	2.17024230
47	Absent thumb (HP:0009777)	2.12638605
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.12404145
49	Absent/shortened dynein arms (HP:0200106)	2.12404145
50	Delayed CNS myelination (HP:0002188)	2.10171606
51	Hypoplastic female external genitalia (HP:0012815)	2.09866962
52	Abnormality of homocysteine metabolism (HP:0010919)	2.09657756
53	Homocystinuria (HP:0002156)	2.09657756
54	Partial duplication of thumb phalanx (HP:0009944)	2.06065022
55	Intellectual disability, profound (HP:0002187)	2.04574434
56	Chronic hepatic failure (HP:0100626)	2.02954354
57	Oligodactyly (HP:0012165)	2.02651955
58	Focal motor seizures (HP:0011153)	2.02238900
59	Labial hypoplasia (HP:0000066)	2.01896853
60	Bundle branch block (HP:0011710)	1.96388116
61	Acute necrotizing encephalopathy (HP:0006965)	1.95842844
62	Broad-based gait (HP:0002136)	1.94942149
63	Abnormality of incisor morphology (HP:0011063)	1.93996815
64	Hypoplasia of the pons (HP:0012110)	1.93594971
65	Optic nerve hypoplasia (HP:0000609)	1.93064241
66	Triphalangeal thumb (HP:0001199)	1.91095276
67	Medial flaring of the eyebrow (HP:0010747)	1.90628711
68	Supernumerary spleens (HP:0009799)	1.89912165
69	True hermaphroditism (HP:0010459)	1.89785938
70	Cutaneous finger syndactyly (HP:0010554)	1.89362808
71	Cutaneous syndactyly (HP:0012725)	1.88848037
72	Abnormal drinking behavior (HP:0030082)	1.88781205
73	Polydipsia (HP:0001959)	1.88781205
74	Large for gestational age (HP:0001520)	1.88632364
75	Forearm undergrowth (HP:0009821)	1.87183927
76	Coronal craniosynostosis (HP:0004440)	1.86140580
77	Abnormal respiratory motile cilium morphology (HP:0005938)	1.86055127
78	Abnormal respiratory epithelium morphology (HP:0012253)	1.86055127
79	Intestinal atresia (HP:0011100)	1.84723624
80	Gait imbalance (HP:0002141)	1.84661279
81	Double outlet right ventricle (HP:0001719)	1.83999832
82	Congenital malformation of the right heart (HP:0011723)	1.83999832
83	Abnormality of the septum pellucidum (HP:0007375)	1.82048777
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81562894
85	Macroglossia (HP:0000158)	1.81475928
86	Hypoplasia of the ulna (HP:0003022)	1.81397525
87	Abnormality of the labia minora (HP:0012880)	1.81255001
88	Abnormality of the 4th metacarpal (HP:0010012)	1.80862136
89	Abnormal number of erythroid precursors (HP:0012131)	1.80849383
90	Rib fusion (HP:0000902)	1.79717115
91	Hypomagnesemia (HP:0002917)	1.77064187
92	Anencephaly (HP:0002323)	1.75703860
93	Meningocele (HP:0002435)	1.74940339
94	Tented upper lip vermilion (HP:0010804)	1.74862508
95	Hypoplastic iliac wings (HP:0002866)	1.74712550
96	Disproportionate short-trunk short stature (HP:0003521)	1.74620211
97	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.74333131
98	Hypoplasia of the brainstem (HP:0002365)	1.74333131
99	Holoprosencephaly (HP:0001360)	1.73600727
100	Hypoplastic pelvis (HP:0008839)	1.72993264

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	3.61159731
2	MAP3K4	3.59344264
3	CASK	3.14254466
4	BCKDK	3.09844992
5	FRK	3.06616587
6	TNIK	2.99672566
7	ZAK	2.88902310
8	DYRK2	2.73437795
9	WNK3	2.52377212
10	GRK1	2.25630835
11	TXK	2.16238444
12	CDC7	2.02643009
13	PINK1	1.99980598
14	CAMKK2	1.96630480
15	WEE1	1.84212572
16	BRSK2	1.79729859
17	TYRO3	1.73960116
18	WNK4	1.72435227
19	PNCK	1.64878425
20	ADRBK1	1.56133192
21	MARK1	1.55099089
22	PRKCG	1.47683539
23	CAMK1	1.34893822
24	PIK3CA	1.29760846
25	CDK8	1.29326951
26	MAP3K7	1.25131220
27	STK11	1.20533570
28	STK16	1.20059790
29	PASK	1.18203810
30	BUB1	1.11955249
31	FGFR2	1.09989415
32	MAP2K6	1.06373137
33	CDK19	1.05706338
34	BRSK1	1.05516360
35	LRRK2	1.02546670
36	MAP4K2	1.01156112
37	CAMK4	1.00080455
38	CAMKK1	0.98181384
39	NTRK2	0.97046415
40	TRIM28	0.96378961
41	STK39	0.89276533
42	PKN1	0.88812339
43	TGFBR1	0.87991640
44	STK38L	0.87674748
45	IRAK4	0.84452268
46	SIK2	0.84335491
47	AURKB	0.84157972
48	INSRR	0.84040701
49	TIE1	0.83779191
50	MAPK13	0.81720372
51	MARK3	0.81690419
52	OXSR1	0.79970270
53	EPHA4	0.75598252
54	CCNB1	0.72147215
55	EPHB2	0.71661799
56	MAP3K11	0.71502406
57	MARK2	0.70728212
58	CSNK1E	0.69794660
59	CAMK2A	0.66642259
60	MAP2K4	0.66082479
61	MKNK2	0.66043548
62	RPS6KA6	0.65629711
63	TLK1	0.63444728
64	CSNK2A2	0.62525257
65	STK3	0.61246838
66	PRKAA1	0.60147193
67	PRKACA	0.59880926
68	PAK3	0.59731123
69	STK24	0.59594958
70	PRKCQ	0.58915726
71	ERBB2	0.58362190
72	PRKCA	0.58217826
73	PLK3	0.57186922
74	PRKCZ	0.56870589
75	MAPKAPK5	0.56140195
76	PLK1	0.55847725
77	IRAK1	0.55346257
78	DAPK3	0.55187887
79	PRKACG	0.53682370
80	BMPR1B	0.51788904
81	CSNK1G2	0.51577241
82	NTRK3	0.51377506
83	PDK2	0.49424099
84	PHKG2	0.48705207
85	PHKG1	0.48705207
86	MAP4K1	0.47624993
87	OBSCN	0.47589724
88	SGK1	0.47512788
89	NUAK1	0.47225118
90	FGFR3	0.45022993
91	CSNK2A1	0.44871072
92	MKNK1	0.44164500
93	SRPK1	0.42371710
94	GRK7	0.39499094
95	FGFR1	0.39461466
96	ATM	0.39359472
97	AKT1	0.37976272
98	RPS6KL1	0.37456919
99	RPS6KC1	0.37456919
100	PRKDC	0.37345328

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.85771676
2	Phototransduction_Homo sapiens_hsa04744	3.47119081
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.94986366
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.83927477
5	Protein export_Homo sapiens_hsa03060	2.44186276
6	Parkinsons disease_Homo sapiens_hsa05012	2.42949303
7	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.40983216
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.38940324
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.11914641
10	Basal cell carcinoma_Homo sapiens_hsa05217	2.07704280
11	Nicotine addiction_Homo sapiens_hsa05033	2.06498666
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.93147388
13	Homologous recombination_Homo sapiens_hsa03440	1.89000378
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.87214361
15	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.74814709
16	Alzheimers disease_Homo sapiens_hsa05010	1.68544644
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68146496
18	Huntingtons disease_Homo sapiens_hsa05016	1.65002672
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.64801277
20	Folate biosynthesis_Homo sapiens_hsa00790	1.51026494
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.49567668
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.42507397
23	Morphine addiction_Homo sapiens_hsa05032	1.40952146
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39280056
25	DNA replication_Homo sapiens_hsa03030	1.39258221
26	Taste transduction_Homo sapiens_hsa04742	1.39237471
27	Olfactory transduction_Homo sapiens_hsa04740	1.36973638
28	One carbon pool by folate_Homo sapiens_hsa00670	1.31558202
29	Peroxisome_Homo sapiens_hsa04146	1.28889064
30	Sulfur relay system_Homo sapiens_hsa04122	1.27791483
31	RNA degradation_Homo sapiens_hsa03018	1.26999827
32	Propanoate metabolism_Homo sapiens_hsa00640	1.25049893
33	RNA polymerase_Homo sapiens_hsa03020	1.19311632
34	Mismatch repair_Homo sapiens_hsa03430	1.17651255
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.02217151
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.01790403
37	Basal transcription factors_Homo sapiens_hsa03022	0.97243671
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.97203304
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95961924
40	Tryptophan metabolism_Homo sapiens_hsa00380	0.94046381
41	Arginine and proline metabolism_Homo sapiens_hsa00330	0.88606293
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.87109644
43	Pyrimidine metabolism_Homo sapiens_hsa00240	0.82203645
44	Circadian rhythm_Homo sapiens_hsa04710	0.80496465
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79683337
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.79519462
47	Insulin secretion_Homo sapiens_hsa04911	0.79498807
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.78455042
49	Base excision repair_Homo sapiens_hsa03410	0.74434235
50	Purine metabolism_Homo sapiens_hsa00230	0.72956714
51	GABAergic synapse_Homo sapiens_hsa04727	0.71581144
52	Circadian entrainment_Homo sapiens_hsa04713	0.71050476
53	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.70162313
54	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.69499077
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.69268902
56	Axon guidance_Homo sapiens_hsa04360	0.69139815
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.68290473
58	Retinol metabolism_Homo sapiens_hsa00830	0.67089868
59	Regulation of autophagy_Homo sapiens_hsa04140	0.65365026
60	Serotonergic synapse_Homo sapiens_hsa04726	0.63849368
61	Fatty acid degradation_Homo sapiens_hsa00071	0.63822688
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.63269948
63	Caffeine metabolism_Homo sapiens_hsa00232	0.61125821
64	Salivary secretion_Homo sapiens_hsa04970	0.61010570
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60881908
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60241201
67	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59791821
68	Hippo signaling pathway_Homo sapiens_hsa04390	0.59451506
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.58757660
70	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.58687143
71	Notch signaling pathway_Homo sapiens_hsa04330	0.57550343
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57348243
73	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.56903702
74	Metabolic pathways_Homo sapiens_hsa01100	0.56264793
75	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.56181066
76	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50700716
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49287348
78	Mineral absorption_Homo sapiens_hsa04978	0.47826034
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.47054629
80	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.45139089
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45044282
82	Butanoate metabolism_Homo sapiens_hsa00650	0.43978892
83	ABC transporters_Homo sapiens_hsa02010	0.43323869
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42165042
85	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.41502689
86	Wnt signaling pathway_Homo sapiens_hsa04310	0.40528513
87	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.40138325
88	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.40008681
89	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.37644505
90	Melanogenesis_Homo sapiens_hsa04916	0.36124124
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.32850474
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31458662
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.31155952
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30178328
95	Proteasome_Homo sapiens_hsa03050	0.28429518
96	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.27831182
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.24893988
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.24534430
99	Histidine metabolism_Homo sapiens_hsa00340	0.22926733
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.22094191

RPL21P24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »