ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.01279758
2	cytidine metabolic process (GO:0046087)	4.62998918
3	cytidine catabolic process (GO:0006216)	4.62998918
4	cytidine deamination (GO:0009972)	4.62998918
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.14160773
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.09731492
7	ATP synthesis coupled proton transport (GO:0015986)	4.09731492
8	protein neddylation (GO:0045116)	4.03677885
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.02101828
10	respiratory chain complex IV assembly (GO:0008535)	3.98324767
11	platelet dense granule organization (GO:0060155)	3.94766943
12	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.91735489
13	proteasome assembly (GO:0043248)	3.89815006
14	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.87914101
15	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.83309144
16	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.79891112
17	protein complex biogenesis (GO:0070271)	3.72498896
18	cytochrome complex assembly (GO:0017004)	3.70635074
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.70423559
20	ribosomal small subunit assembly (GO:0000028)	3.57417743
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.42705766
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.42705766
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.31956307
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.31007400
25	NADH dehydrogenase complex assembly (GO:0010257)	3.31007400
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.31007400
27	respiratory electron transport chain (GO:0022904)	3.26995955
28	chaperone-mediated protein transport (GO:0072321)	3.26680671
29	electron transport chain (GO:0022900)	3.26621021
30	response to pheromone (GO:0019236)	3.25468706
31	cell wall macromolecule metabolic process (GO:0044036)	3.23833255
32	water-soluble vitamin biosynthetic process (GO:0042364)	3.14286233
33	behavioral response to nicotine (GO:0035095)	3.13309577
34	DNA double-strand break processing (GO:0000729)	2.96757833
35	pseudouridine synthesis (GO:0001522)	2.94640877
36	replication fork processing (GO:0031297)	2.93089656
37	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.92649716
38	termination of RNA polymerase III transcription (GO:0006386)	2.92649716
39	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.90303053
40	response to interferon-beta (GO:0035456)	2.84554405
41	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.83664945
42	cell wall macromolecule catabolic process (GO:0016998)	2.82320409
43	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.80437053
44	tryptophan catabolic process (GO:0006569)	2.79217458
45	indole-containing compound catabolic process (GO:0042436)	2.79217458
46	indolalkylamine catabolic process (GO:0046218)	2.79217458
47	regulation of cellular amino acid metabolic process (GO:0006521)	2.78305065
48	DNA demethylation (GO:0080111)	2.75159920
49	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.71514783
50	cellular response to interferon-beta (GO:0035458)	2.69938452
51	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.67604674
52	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.65874052
53	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.65874052
54	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.65874052
55	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.64378760
56	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.61108081
57	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.61108081
58	mannosylation (GO:0097502)	2.61019529
59	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.59788091
60	kynurenine metabolic process (GO:0070189)	2.58855017
61	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.58147507
62	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.57417239
63	isotype switching (GO:0045190)	2.57417239
64	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.57417239
65	GTP biosynthetic process (GO:0006183)	2.57033911
66	positive regulation of respiratory burst (GO:0060267)	2.56705773
67	DNA catabolic process, exonucleolytic (GO:0000738)	2.56415941
68	indolalkylamine metabolic process (GO:0006586)	2.55865699
69	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.55775870
70	protein K6-linked ubiquitination (GO:0085020)	2.53032022
71	recombinational repair (GO:0000725)	2.50923450
72	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.50825684
73	double-strand break repair via homologous recombination (GO:0000724)	2.48816240
74	protein-cofactor linkage (GO:0018065)	2.48000829
75	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.47620727
76	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.46965988
77	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.46965988
78	piRNA metabolic process (GO:0034587)	2.46674287
79	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.45702855
80	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.45557427
81	peptidyl-histidine modification (GO:0018202)	2.44412736
82	tryptophan metabolic process (GO:0006568)	2.44339093
83	ribosomal large subunit biogenesis (GO:0042273)	2.43254750
84	hydrogen ion transmembrane transport (GO:1902600)	2.43143967
85	synapsis (GO:0007129)	2.43118598
86	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.42373983
87	chromatin remodeling at centromere (GO:0031055)	2.41433111
88	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.40777791
89	regulation of mitotic spindle checkpoint (GO:1903504)	2.39497087
90	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.39497087
91	adaptation of signaling pathway (GO:0023058)	2.39390012
92	regulation of hypersensitivity (GO:0002883)	2.39382800
93	preassembly of GPI anchor in ER membrane (GO:0016254)	2.38669759
94	ATP biosynthetic process (GO:0006754)	2.37744532
95	positive regulation of calcium-mediated signaling (GO:0050850)	2.37473540
96	DNA dealkylation (GO:0035510)	2.37220939
97	proton transport (GO:0015992)	2.36015256
98	mismatch repair (GO:0006298)	2.35716292
99	rhodopsin mediated signaling pathway (GO:0016056)	2.35466849
100	axoneme assembly (GO:0035082)	2.35038652

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.55304042
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.36208277
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.24687904
4	VDR_22108803_ChIP-Seq_LS180_Human	2.96974645
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.93377119
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.92347655
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.77398219
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.73098718
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.65835781
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.59296865
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54890097
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.29662551
13	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.08303361
14	* VDR_23849224_ChIP-Seq_CD4+_Human	2.08228403
15	EWS_26573619_Chip-Seq_HEK293_Human	1.98349391
16	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.95465472
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.93862117
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.89631909
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.87947998
20	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.81446293
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78652289
22	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.78608881
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.77737971
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.77267677
25	P300_19829295_ChIP-Seq_ESCs_Human	1.74619786
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71590596
27	FUS_26573619_Chip-Seq_HEK293_Human	1.70650514
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.68135698
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67045804
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.63744782
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.60251292
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.55416985
33	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.52343681
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.51739183
35	* TP53_22573176_ChIP-Seq_HFKS_Human	1.50740297
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.50644286
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.50644286
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.49598129
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.49023263
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.49023263
41	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.48707907
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.46690284
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46420087
44	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.45857083
45	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.45285284
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.44802969
47	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.42906031
48	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.37228012
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37219344
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.36310347
51	AR_20517297_ChIP-Seq_VCAP_Human	1.36163241
52	GBX2_23144817_ChIP-Seq_PC3_Human	1.34359314
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33044712
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.33044712
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.32976597
56	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.32160740
57	GATA3_26560356_Chip-Seq_TH2_Human	1.30963316
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29498512
59	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.28290124
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.27214390
61	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24652319
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.22668184
63	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22074186
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21294133
65	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21041946
66	NCOR_22424771_ChIP-Seq_293T_Human	1.16949966
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16632044
68	EZH2_22144423_ChIP-Seq_EOC_Human	1.16248895
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16113549
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14108719
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12699686
72	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12652074
73	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10841440
74	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10229719
75	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09668701
76	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.09332102
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06872535
78	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06692540
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05885317
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04986108
81	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.04648675
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.03794942
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.02534700
84	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02510789
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02113840
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01867755
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01689851
88	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01611697
89	RBPJ_21746931_ChIP-Seq_IB4_Human	0.99853186
90	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99028092
91	CDX2_22108803_ChIP-Seq_LS180_Human	0.98348751
92	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97514654
93	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97287595
94	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94955619
95	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.94916893
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.94175057
97	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.93699239
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.93262586
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.92530504
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.91932886

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.22492716
2	MP0005671_abnormal_response_to	2.94153167
3	MP0002102_abnormal_ear_morphology	2.60041225
4	MP0008877_abnormal_DNA_methylation	2.54137041
5	MP0000372_irregular_coat_pigmentation	2.51186517
6	MP0006072_abnormal_retinal_apoptosis	2.51164520
7	MP0001835_abnormal_antigen_presentation	2.43782067
8	MP0008872_abnormal_physiological_respon	2.32550797
9	MP0008875_abnormal_xenobiotic_pharmacok	2.23598446
10	MP0003806_abnormal_nucleotide_metabolis	2.19141849
11	MP0006292_abnormal_olfactory_placode	2.15571190
12	MP0005646_abnormal_pituitary_gland	2.14240347
13	MP0005075_abnormal_melanosome_morpholog	2.07091862
14	MP0003787_abnormal_imprinting	2.05440278
15	MP0005551_abnormal_eye_electrophysiolog	2.04810665
16	MP0005645_abnormal_hypothalamus_physiol	2.03563223
17	MP0003195_calcinosis	1.96749232
18	MP0002876_abnormal_thyroid_physiology	1.92557740
19	MP0002837_dystrophic_cardiac_calcinosis	1.84826412
20	MP0003646_muscle_fatigue	1.83956092
21	MP0009697_abnormal_copulation	1.79455992
22	MP0005174_abnormal_tail_pigmentation	1.71773806
23	MP0004147_increased_porphyrin_level	1.68602610
24	MP0003786_premature_aging	1.68515975
25	MP0001968_abnormal_touch/_nociception	1.62638720
26	MP0002736_abnormal_nociception_after	1.58448838
27	MP0009785_altered_susceptibility_to	1.58211494
28	MP0005253_abnormal_eye_physiology	1.51849164
29	MP0001873_stomach_inflammation	1.51169684
30	MP0002148_abnormal_hypersensitivity_rea	1.51019893
31	MP0008058_abnormal_DNA_repair	1.48861305
32	MP0000685_abnormal_immune_system	1.46403976
33	MP0005084_abnormal_gallbladder_morpholo	1.45390909
34	MP0002163_abnormal_gland_morphology	1.43603925
35	MP0001485_abnormal_pinna_reflex	1.40301785
36	MP0004142_abnormal_muscle_tone	1.39385750
37	MP0006036_abnormal_mitochondrial_physio	1.36595591
38	MP0004145_abnormal_muscle_electrophysio	1.36012900
39	MP0003011_delayed_dark_adaptation	1.30693270
40	MP0009046_muscle_twitch	1.28900636
41	MP0003186_abnormal_redox_activity	1.26529975
42	MP0004885_abnormal_endolymph	1.24961644
43	MP0002095_abnormal_skin_pigmentation	1.24689888
44	MP0009764_decreased_sensitivity_to	1.24602724
45	MP0001800_abnormal_humoral_immune	1.24092867
46	MP0005389_reproductive_system_phenotype	1.18269009
47	MP0001986_abnormal_taste_sensitivity	1.15318703
48	MP0001293_anophthalmia	1.13121195
49	MP0006082_CNS_inflammation	1.11889524
50	MP0003866_abnormal_defecation	1.11624898
51	MP0002938_white_spotting	1.11212361
52	MP0002138_abnormal_hepatobiliary_system	1.11165648
53	MP0001501_abnormal_sleep_pattern	1.10254957
54	MP0008789_abnormal_olfactory_epithelium	1.09654866
55	MP0001764_abnormal_homeostasis	1.09621623
56	MP0003718_maternal_effect	1.08709551
57	MP0010094_abnormal_chromosome_stability	1.08397106
58	MP0000516_abnormal_urinary_system	1.07044848
59	MP0005367_renal/urinary_system_phenotyp	1.07044848
60	MP0002234_abnormal_pharynx_morphology	1.06342818
61	MP0001905_abnormal_dopamine_level	1.06188872
62	MP0000631_abnormal_neuroendocrine_gland	1.06139446
63	MP0001853_heart_inflammation	1.05016458
64	MP0005000_abnormal_immune_tolerance	1.04909991
65	MP0008995_early_reproductive_senescence	1.04427732
66	MP0005410_abnormal_fertilization	1.03256699
67	MP0005636_abnormal_mineral_homeostasis	1.02758058
68	MP0002272_abnormal_nervous_system	1.02166281
69	MP0009333_abnormal_splenocyte_physiolog	1.00521485
70	MP0005360_urolithiasis	1.00152733
71	MP0001984_abnormal_olfaction	0.99964438
72	MP0009745_abnormal_behavioral_response	0.99863089
73	MP0000427_abnormal_hair_cycle	0.99746390
74	MP0002166_altered_tumor_susceptibility	0.97373944
75	MP0002638_abnormal_pupillary_reflex	0.96776280
76	MP0005387_immune_system_phenotype	0.96532849
77	MP0001790_abnormal_immune_system	0.96532849
78	MP0002723_abnormal_immune_serum	0.94522982
79	MP0002420_abnormal_adaptive_immunity	0.94225054
80	MP0001919_abnormal_reproductive_system	0.92731421
81	MP0000569_abnormal_digit_pigmentation	0.92550335
82	MP0001819_abnormal_immune_cell	0.91552627
83	MP0002160_abnormal_reproductive_system	0.89790737
84	MP0002006_tumorigenesis	0.89222102
85	MP0002452_abnormal_antigen_presenting	0.86125967
86	MP0005377_hearing/vestibular/ear_phenot	0.85710875
87	MP0003878_abnormal_ear_physiology	0.85710875
88	MP0004043_abnormal_pH_regulation	0.85646166
89	MP0002277_abnormal_respiratory_mucosa	0.85309665
90	MP0005379_endocrine/exocrine_gland_phen	0.83766039
91	MP0002693_abnormal_pancreas_physiology	0.83467625
92	MP0003880_abnormal_central_pattern	0.81857149
93	MP0001119_abnormal_female_reproductive	0.81107442
94	MP0003121_genomic_imprinting	0.80508291
95	MP0005025_abnormal_response_to	0.80071592
96	MP0002090_abnormal_vision	0.79945130
97	MP0002254_reproductive_system_inflammat	0.79318470
98	MP0003763_abnormal_thymus_physiology	0.79030035
99	MP0010155_abnormal_intestine_physiology	0.77661329
100	MP0005332_abnormal_amino_acid	0.77650209

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.89363134
2	Congenital stationary night blindness (HP:0007642)	3.83864480
3	Pancreatic cysts (HP:0001737)	3.80603285
4	Mitochondrial inheritance (HP:0001427)	3.58535693
5	Progressive macrocephaly (HP:0004481)	3.40029727
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.37680759
7	Acute encephalopathy (HP:0006846)	3.34014428
8	Pancreatic fibrosis (HP:0100732)	3.33581278
9	3-Methylglutaconic aciduria (HP:0003535)	3.30508142
10	True hermaphroditism (HP:0010459)	3.22788559
11	Hepatocellular necrosis (HP:0001404)	3.22616900
12	Hypoproteinemia (HP:0003075)	3.21983407
13	Increased CSF lactate (HP:0002490)	3.21581727
14	Molar tooth sign on MRI (HP:0002419)	3.08507580
15	Abnormality of midbrain morphology (HP:0002418)	3.08507580
16	IgG deficiency (HP:0004315)	2.91807512
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.90953416
18	Hepatic necrosis (HP:0002605)	2.89225282
19	Nephronophthisis (HP:0000090)	2.80836230
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.77232284
21	Aplastic anemia (HP:0001915)	2.72684610
22	Abolished electroretinogram (ERG) (HP:0000550)	2.66997534
23	Lipid accumulation in hepatocytes (HP:0006561)	2.64393913
24	Cerebral edema (HP:0002181)	2.62168256
25	Abnormality of B cell number (HP:0010975)	2.61237873
26	Increased hepatocellular lipid droplets (HP:0006565)	2.57376737
27	Stomatitis (HP:0010280)	2.51023892
28	Thyroiditis (HP:0100646)	2.47076154
29	Attenuation of retinal blood vessels (HP:0007843)	2.43655816
30	Optic disc pallor (HP:0000543)	2.38073878
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.36573618
32	Severe combined immunodeficiency (HP:0004430)	2.36511071
33	Reticulocytopenia (HP:0001896)	2.35520329
34	Sclerocornea (HP:0000647)	2.35064327
35	Abnormality of the renal cortex (HP:0011035)	2.34372850
36	Congenital, generalized hypertrichosis (HP:0004540)	2.33263495
37	Abnormality of the renal medulla (HP:0100957)	2.29052536
38	B lymphocytopenia (HP:0010976)	2.27238219
39	Constricted visual fields (HP:0001133)	2.25278841
40	Abnormal biliary tract physiology (HP:0012439)	2.23278673
41	Bile duct proliferation (HP:0001408)	2.23278673
42	Colon cancer (HP:0003003)	2.23140724
43	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.20666652
44	Asplenia (HP:0001746)	2.19750418
45	Cystic liver disease (HP:0006706)	2.17885129
46	Increased serum lactate (HP:0002151)	2.15959751
47	Male pseudohermaphroditism (HP:0000037)	2.10215474
48	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.09569194
49	Pendular nystagmus (HP:0012043)	2.07401148
50	Decreased central vision (HP:0007663)	2.06239148
51	Medial flaring of the eyebrow (HP:0010747)	2.05987366
52	Keratoconus (HP:0000563)	2.04174452
53	Increased corneal curvature (HP:0100692)	2.04174452
54	Lethargy (HP:0001254)	2.03704035
55	Abnormality of the prostate (HP:0008775)	2.02490437
56	Renal cortical cysts (HP:0000803)	2.01225111
57	Abnormality of the ileum (HP:0001549)	1.99925395
58	Lactic acidosis (HP:0003128)	1.98176869
59	Renal Fanconi syndrome (HP:0001994)	1.97948160
60	Absent thumb (HP:0009777)	1.94203106
61	Meckel diverticulum (HP:0002245)	1.93788534
62	Increased intramyocellular lipid droplets (HP:0012240)	1.93227529
63	Autoimmune hemolytic anemia (HP:0001890)	1.92502985
64	Hypoalbuminemia (HP:0003073)	1.91353574
65	Abnormal albumin level (HP:0012116)	1.91353574
66	Hypothermia (HP:0002045)	1.90771892
67	Aplasia/hypoplasia of the uterus (HP:0008684)	1.89864405
68	Exertional dyspnea (HP:0002875)	1.88813282
69	Methylmalonic acidemia (HP:0002912)	1.88508006
70	Type 2 muscle fiber atrophy (HP:0003554)	1.88225762
71	Elevated erythrocyte sedimentation rate (HP:0003565)	1.84843585
72	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.84573556
73	Respiratory failure (HP:0002878)	1.83739105
74	Combined immunodeficiency (HP:0005387)	1.81249677
75	Polydipsia (HP:0001959)	1.80513834
76	Abnormal drinking behavior (HP:0030082)	1.80513834
77	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79695923
78	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.78467479
79	Methylmalonic aciduria (HP:0012120)	1.78117365
80	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.77759948
81	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.76206853
82	Abnormality of T cells (HP:0002843)	1.75596036
83	Panhypogammaglobulinemia (HP:0003139)	1.74960118
84	Congenital hepatic fibrosis (HP:0002612)	1.73314629
85	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.72337075
86	Absent/shortened dynein arms (HP:0200106)	1.72337075
87	Triphalangeal thumb (HP:0001199)	1.71366278
88	Abnormality of urine glucose concentration (HP:0011016)	1.70579888
89	Glycosuria (HP:0003076)	1.70579888
90	Leukodystrophy (HP:0002415)	1.70456888
91	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.70007978
92	Increased muscle lipid content (HP:0009058)	1.69680968
93	Hypoplasia of the fovea (HP:0007750)	1.69158045
94	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.69158045
95	Clubbing of toes (HP:0100760)	1.68648351
96	Furrowed tongue (HP:0000221)	1.68237774
97	Abnormality of T cell number (HP:0011839)	1.67349391
98	Abnormality of macular pigmentation (HP:0008002)	1.67088906
99	Tubular atrophy (HP:0000092)	1.66158536
100	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.65991741

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.51047945
2	FRK	3.27974808
3	NUAK1	3.18407145
4	EIF2AK1	2.66853289
5	GRK1	2.60200112
6	ZAK	2.57523133
7	EIF2AK3	2.51267800
8	ADRBK2	2.30105347
9	TRIM28	2.28719278
10	MAP4K2	2.28399133
11	VRK2	2.24501242
12	MST4	2.10169690
13	CDK19	2.05096328
14	BCKDK	1.97201532
15	TAOK3	1.95386427
16	MAP3K12	1.83096873
17	OXSR1	1.74703337
18	WNK3	1.70435057
19	BMPR1B	1.61492776
20	KDR	1.60402368
21	PINK1	1.50162285
22	VRK1	1.44166876
23	WNK4	1.42331954
24	TEC	1.39977712
25	INSRR	1.37968859
26	ITK	1.37573910
27	TLK1	1.36355263
28	PLK4	1.36236511
29	STK39	1.25992406
30	ERBB3	1.19163551
31	PLK3	1.15050386
32	WEE1	1.13619209
33	BUB1	1.12407853
34	PASK	1.07514548
35	ACVR1B	1.06655272
36	PLK2	1.05566051
37	MUSK	1.00778384
38	TESK2	0.93683762
39	MYLK	0.90805852
40	TIE1	0.89520320
41	BMPR2	0.87679849
42	EIF2AK2	0.86049954
43	NEK1	0.85667355
44	MAP4K1	0.85063849
45	KIT	0.84490670
46	DYRK2	0.81643119
47	ADRBK1	0.81405541
48	SYK	0.79668991
49	CDC7	0.79098719
50	BRSK2	0.78113163
51	PIK3CA	0.76134544
52	MKNK2	0.75278691
53	DAPK1	0.72227334
54	PIM2	0.71761197
55	DAPK2	0.71333875
56	PRKCQ	0.70985542
57	MAP2K6	0.70781773
58	FES	0.70544703
59	TNK2	0.70453708
60	TAF1	0.69285899
61	IKBKB	0.67305821
62	MAPK13	0.66546775
63	GRK7	0.64653286
64	PRKCE	0.63903957
65	CSNK1G3	0.63773113
66	PIK3CG	0.61022205
67	NME1	0.60250199
68	GRK5	0.59741913
69	LYN	0.59602206
70	MKNK1	0.59456830
71	CSNK1G2	0.58170911
72	SRPK1	0.57152491
73	BTK	0.56776914
74	CSNK1G1	0.56479675
75	MAP3K4	0.55963479
76	PBK	0.55214841
77	CCNB1	0.52324506
78	SCYL2	0.52029375
79	PLK1	0.51566294
80	OBSCN	0.50284898
81	RPS6KA5	0.50246584
82	MAPKAPK5	0.50155550
83	TNIK	0.48509206
84	MARK3	0.47980740
85	PRKCG	0.47255313
86	IGF1R	0.44775173
87	FLT3	0.43353725
88	PAK3	0.40286616
89	ATR	0.39680801
90	LCK	0.39645588
91	CSF1R	0.38950713
92	PRKCA	0.38405919
93	PRKACA	0.38192265
94	PKN1	0.37604180
95	CSNK2A1	0.37440272
96	MINK1	0.36543755
97	AURKB	0.36316508
98	CSNK1A1L	0.36311983
99	CSNK1A1	0.35148640
100	STK38L	0.33766008

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.39542968
2	Proteasome_Homo sapiens_hsa03050	3.27957300
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.09200681
4	Protein export_Homo sapiens_hsa03060	2.58924143
5	Allograft rejection_Homo sapiens_hsa05330	2.58115960
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.53710146
7	Parkinsons disease_Homo sapiens_hsa05012	2.48457823
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.45587888
9	Ribosome_Homo sapiens_hsa03010	2.42967592
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.41325585
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.32036755
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.22465687
13	Homologous recombination_Homo sapiens_hsa03440	2.08814074
14	RNA polymerase_Homo sapiens_hsa03020	2.03103827
15	Caffeine metabolism_Homo sapiens_hsa00232	2.02003689
16	Phototransduction_Homo sapiens_hsa04744	1.96720729
17	Mismatch repair_Homo sapiens_hsa03430	1.65115878
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.64457929
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64181746
20	Alzheimers disease_Homo sapiens_hsa05010	1.60223519
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58021708
22	RNA degradation_Homo sapiens_hsa03018	1.54420205
23	Huntingtons disease_Homo sapiens_hsa05016	1.50441558
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.47687703
25	Propanoate metabolism_Homo sapiens_hsa00640	1.42979952
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.42180530
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41062552
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.39302297
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.35682950
30	One carbon pool by folate_Homo sapiens_hsa00670	1.27594431
31	Basal transcription factors_Homo sapiens_hsa03022	1.25213119
32	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.22955545
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.22602400
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.22475546
35	DNA replication_Homo sapiens_hsa03030	1.21977326
36	Butanoate metabolism_Homo sapiens_hsa00650	1.19937373
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.17684658
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.17562571
39	Non-homologous end-joining_Homo sapiens_hsa03450	1.17338030
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.16595943
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.14499239
42	Nitrogen metabolism_Homo sapiens_hsa00910	1.10437620
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.08855841
44	Nucleotide excision repair_Homo sapiens_hsa03420	1.07002418
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04743119
46	Tryptophan metabolism_Homo sapiens_hsa00380	1.02898367
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.02857846
48	Peroxisome_Homo sapiens_hsa04146	1.01677317
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01654851
50	Retinol metabolism_Homo sapiens_hsa00830	1.00011981
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99942252
52	Purine metabolism_Homo sapiens_hsa00230	0.97787560
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.96664920
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.96064652
55	Base excision repair_Homo sapiens_hsa03410	0.83965150
56	Olfactory transduction_Homo sapiens_hsa04740	0.82803329
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82578840
58	Sulfur metabolism_Homo sapiens_hsa00920	0.81723376
59	Regulation of autophagy_Homo sapiens_hsa04140	0.80947590
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80646517
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78134214
62	Fatty acid elongation_Homo sapiens_hsa00062	0.77998834
63	Viral myocarditis_Homo sapiens_hsa05416	0.74931753
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74539828
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.72531668
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71405887
67	RNA transport_Homo sapiens_hsa03013	0.66602515
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.65967691
69	Spliceosome_Homo sapiens_hsa03040	0.65226176
70	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.64972745
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.64706684
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.63878620
73	Metabolic pathways_Homo sapiens_hsa01100	0.58592407
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.58297742
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54614268
76	Fatty acid degradation_Homo sapiens_hsa00071	0.53810661
77	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.53389339
78	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53383980
79	Glutathione metabolism_Homo sapiens_hsa00480	0.52028181
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50279965
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.48608077
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.48155556
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46783828
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46602675
85	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.45997267
86	Salivary secretion_Homo sapiens_hsa04970	0.44005335
87	Taste transduction_Homo sapiens_hsa04742	0.41717018
88	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40677137
89	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.40439876
90	Mineral absorption_Homo sapiens_hsa04978	0.39747123
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.38996541
92	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.38311858
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36822578
94	Nicotine addiction_Homo sapiens_hsa05033	0.34171319
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.32460329
96	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.29676539
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.26340359
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.24123326
99	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.20864910
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20184376

RPL21P28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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