

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 7.57264044 |
| 2 | chaperone-mediated protein transport (GO:0072321) | 7.38808393 |
| 3 | preassembly of GPI anchor in ER membrane (GO:0016254) | 6.75819069 |
| 4 | viral transcription (GO:0019083) | 6.38852900 |
| 5 | translational termination (GO:0006415) | 6.12256444 |
| 6 | ribosomal small subunit assembly (GO:0000028) | 5.45102808 |
| 7 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.41852160 |
| 8 | cotranslational protein targeting to membrane (GO:0006613) | 5.29699251 |
| 9 | protein targeting to ER (GO:0045047) | 5.25953795 |
| 10 | ribosomal small subunit biogenesis (GO:0042274) | 5.25391773 |
| 11 | translational elongation (GO:0006414) | 5.11661432 |
| 12 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 5.02248375 |
| 13 | protein localization to endoplasmic reticulum (GO:0070972) | 4.92220029 |
| 14 | GPI anchor biosynthetic process (GO:0006506) | 4.90020626 |
| 15 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.71969690 |
| 16 | viral life cycle (GO:0019058) | 4.69230364 |
| 17 | GPI anchor metabolic process (GO:0006505) | 4.56027469 |
| 18 | cellular protein complex disassembly (GO:0043624) | 4.49971956 |
| 19 | translational initiation (GO:0006413) | 4.45790665 |
| 20 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 4.45187953 |
| 21 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.42160737 |
| 22 | regulation of immunoglobulin secretion (GO:0051023) | 4.40679651 |
| 23 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.38514180 |
| 24 | DNA deamination (GO:0045006) | 4.25977977 |
| 25 | maturation of SSU-rRNA (GO:0030490) | 4.22004228 |
| 26 | peptidyl-histidine modification (GO:0018202) | 4.07898912 |
| 27 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.98357361 |
| 28 | ATP synthesis coupled proton transport (GO:0015986) | 3.98046184 |
| 29 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.98046184 |
| 30 | intracellular protein transmembrane import (GO:0044743) | 3.95601100 |
| 31 | receptor guanylyl cyclase signaling pathway (GO:0007168) | 3.93052606 |
| 32 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.87342709 |
| 33 | C-terminal protein lipidation (GO:0006501) | 3.86365001 |
| 34 | ribosomal large subunit biogenesis (GO:0042273) | 3.76316257 |
| 35 | translation (GO:0006412) | 3.72630388 |
| 36 | protein complex disassembly (GO:0043241) | 3.72371988 |
| 37 | behavioral response to ethanol (GO:0048149) | 3.64258521 |
| 38 | positive regulation of isotype switching (GO:0045830) | 3.62772630 |
| 39 | behavioral response to nicotine (GO:0035095) | 3.61286074 |
| 40 | C-terminal protein amino acid modification (GO:0018410) | 3.60905504 |
| 41 | protein targeting to mitochondrion (GO:0006626) | 3.58273250 |
| 42 | protein complex biogenesis (GO:0070271) | 3.57808410 |
| 43 | regulation of regulatory T cell differentiation (GO:0045589) | 3.57242034 |
| 44 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.54807364 |
| 45 | positive regulation of DNA recombination (GO:0045911) | 3.49234535 |
| 46 | meiotic chromosome segregation (GO:0045132) | 3.46657828 |
| 47 | macromolecular complex disassembly (GO:0032984) | 3.43100794 |
| 48 | inner mitochondrial membrane organization (GO:0007007) | 3.41695504 |
| 49 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.40292233 |
| 50 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.34960220 |
| 51 | establishment of protein localization to mitochondrion (GO:0072655) | 3.32464936 |
| 52 | protein targeting to membrane (GO:0006612) | 3.29505861 |
| 53 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.26060619 |
| 54 | regulation of RIG-I signaling pathway (GO:0039535) | 3.25353426 |
| 55 | regulation of memory T cell differentiation (GO:0043380) | 3.24631375 |
| 56 | protein localization to mitochondrion (GO:0070585) | 3.23096268 |
| 57 | behavioral defense response (GO:0002209) | 3.22199183 |
| 58 | behavioral fear response (GO:0001662) | 3.22199183 |
| 59 | male meiosis I (GO:0007141) | 3.20880163 |
| 60 | intracellular protein transmembrane transport (GO:0065002) | 3.19912790 |
| 61 | mitochondrial calcium ion transport (GO:0006851) | 3.19696209 |
| 62 | rRNA processing (GO:0006364) | 3.18790807 |
| 63 | rRNA metabolic process (GO:0016072) | 3.13142421 |
| 64 | piRNA metabolic process (GO:0034587) | 3.08216559 |
| 65 | regulation of chronic inflammatory response (GO:0002676) | 3.07142913 |
| 66 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.05403342 |
| 67 | protein transmembrane transport (GO:0071806) | 2.99028328 |
| 68 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.96999468 |
| 69 | kynurenine metabolic process (GO:0070189) | 2.96536046 |
| 70 | glycolipid biosynthetic process (GO:0009247) | 2.94961827 |
| 71 | DNA methylation involved in gamete generation (GO:0043046) | 2.94410973 |
| 72 | positive regulation of prostaglandin secretion (GO:0032308) | 2.91940389 |
| 73 | cell wall macromolecule catabolic process (GO:0016998) | 2.89804100 |
| 74 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.89790707 |
| 75 | NADH dehydrogenase complex assembly (GO:0010257) | 2.89790707 |
| 76 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.89790707 |
| 77 | positive regulation of B cell mediated immunity (GO:0002714) | 2.89130633 |
| 78 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 2.89130633 |
| 79 | positive regulation of cell fate commitment (GO:0010455) | 2.87199343 |
| 80 | mRNA catabolic process (GO:0006402) | 2.86158630 |
| 81 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.84746129 |
| 82 | mannosylation (GO:0097502) | 2.83380031 |
| 83 | proteasome assembly (GO:0043248) | 2.82721958 |
| 84 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.81178679 |
| 85 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.81178679 |
| 86 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.78632039 |
| 87 | fear response (GO:0042596) | 2.78412882 |
| 88 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531) | 2.78004201 |
| 89 | cellular component biogenesis (GO:0044085) | 2.74316292 |
| 90 | positive regulation of sodium ion transmembrane transport (GO:1902307) | 2.73592823 |
| 91 | positive regulation of activated T cell proliferation (GO:0042104) | 2.72354727 |
| 92 | indole-containing compound catabolic process (GO:0042436) | 2.68442144 |
| 93 | indolalkylamine catabolic process (GO:0046218) | 2.68442144 |
| 94 | tryptophan catabolic process (GO:0006569) | 2.68442144 |
| 95 | positive regulation of fatty acid transport (GO:2000193) | 2.68356791 |
| 96 | protein neddylation (GO:0045116) | 2.67193974 |
| 97 | opioid receptor signaling pathway (GO:0038003) | 2.65133533 |
| 98 | positive regulation of immunoglobulin production (GO:0002639) | 2.65107711 |
| 99 | mitochondrial transport (GO:0006839) | 2.63231709 |
| 100 | cornea development in camera-type eye (GO:0061303) | 2.60931143 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.95321065 |
| 2 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.11244587 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.97724533 |
| 4 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.83228126 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.78206616 |
| 6 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.61978656 |
| 7 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.56355350 |
| 8 | IRF1_19129219_ChIP-ChIP_H3396_Human | 2.46312859 |
| 9 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.43508161 |
| 10 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.41535557 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.38045949 |
| 12 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.36741084 |
| 13 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.33495612 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.32383799 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.28160904 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.17819802 |
| 17 | TP53_22573176_ChIP-Seq_HFKS_Human | 2.04425427 |
| 18 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 2.04306651 |
| 19 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.03830545 |
| 20 | VDR_22108803_ChIP-Seq_LS180_Human | 1.99816242 |
| 21 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.97758278 |
| 22 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.93938455 |
| 23 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.89284063 |
| 24 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.86409403 |
| 25 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.79943461 |
| 26 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.72565046 |
| 27 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.70387490 |
| 28 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.70387490 |
| 29 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.63107660 |
| 30 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.57414871 |
| 31 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.56294996 |
| 32 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.53948421 |
| 33 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.52277181 |
| 34 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.49398771 |
| 35 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.47601226 |
| 36 | EWS_26573619_Chip-Seq_HEK293_Human | 1.46474090 |
| 37 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.43017071 |
| 38 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.42162714 |
| 39 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.39435856 |
| 40 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.39042983 |
| 41 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.37701322 |
| 42 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.37596483 |
| 43 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.35010665 |
| 44 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.33289332 |
| 45 | GATA3_26560356_Chip-Seq_TH2_Human | 1.33245763 |
| 46 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.32574483 |
| 47 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.30439685 |
| 48 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.30186361 |
| 49 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.28431242 |
| 50 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.26609150 |
| 51 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.25949382 |
| 52 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.25454157 |
| 53 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.25025565 |
| 54 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.24581425 |
| 55 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.24474270 |
| 56 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.24412523 |
| 57 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.23933301 |
| 58 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.23849670 |
| 59 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.23244631 |
| 60 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.22926748 |
| 61 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.18991038 |
| 62 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.17927579 |
| 63 | P300_19829295_ChIP-Seq_ESCs_Human | 1.17702033 |
| 64 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.17003252 |
| 65 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.15398424 |
| 66 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.15398424 |
| 67 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.13204126 |
| 68 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.11277720 |
| 69 | RAC3_21632823_ChIP-Seq_H3396_Human | 1.10821207 |
| 70 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.10614753 |
| 71 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.10144947 |
| 72 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.10116017 |
| 73 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.10116017 |
| 74 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.10035998 |
| 75 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.09739366 |
| 76 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.08835723 |
| 77 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.07566097 |
| 78 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.07242155 |
| 79 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.07141321 |
| 80 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.05817764 |
| 81 | P300_27268052_Chip-Seq_Bcells_Human | 1.03323550 |
| 82 | AR_20517297_ChIP-Seq_VCAP_Human | 1.02546843 |
| 83 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.01632853 |
| 84 | FUS_26573619_Chip-Seq_HEK293_Human | 1.00860109 |
| 85 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.99567902 |
| 86 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.99267998 |
| 87 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.98382222 |
| 88 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.98163676 |
| 89 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.97263625 |
| 90 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.96116687 |
| 91 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.94940628 |
| 92 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 0.94498163 |
| 93 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.93522180 |
| 94 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.92751539 |
| 95 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 0.92750759 |
| 96 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.91544494 |
| 97 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.91204564 |
| 98 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.89815788 |
| 99 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.88796546 |
| 100 | ERA_21632823_ChIP-Seq_H3396_Human | 0.88765040 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 4.98827776 |
| 2 | MP0003646_muscle_fatigue | 4.82595980 |
| 3 | MP0003011_delayed_dark_adaptation | 3.44481096 |
| 4 | MP0006292_abnormal_olfactory_placode | 3.43612897 |
| 5 | MP0001835_abnormal_antigen_presentation | 2.86860802 |
| 6 | MP0008877_abnormal_DNA_methylation | 2.79185160 |
| 7 | MP0005670_abnormal_white_adipose | 2.51043100 |
| 8 | MP0008789_abnormal_olfactory_epithelium | 2.46639201 |
| 9 | MP0003786_premature_aging | 2.32349879 |
| 10 | MP0002163_abnormal_gland_morphology | 2.31247394 |
| 11 | MP0004145_abnormal_muscle_electrophysio | 2.30941033 |
| 12 | MP0002837_dystrophic_cardiac_calcinosis | 2.21893197 |
| 13 | MP0001986_abnormal_taste_sensitivity | 2.19728642 |
| 14 | MP0003806_abnormal_nucleotide_metabolis | 2.04879110 |
| 15 | MP0003195_calcinosis | 2.02541447 |
| 16 | MP0002909_abnormal_adrenal_gland | 2.01753890 |
| 17 | MP0005671_abnormal_response_to | 2.01502401 |
| 18 | MP0006072_abnormal_retinal_apoptosis | 1.93845827 |
| 19 | MP0000372_irregular_coat_pigmentation | 1.86232669 |
| 20 | MP0005387_immune_system_phenotype | 1.80560073 |
| 21 | MP0001790_abnormal_immune_system | 1.80560073 |
| 22 | MP0004142_abnormal_muscle_tone | 1.79889245 |
| 23 | MP0008872_abnormal_physiological_respon | 1.77873069 |
| 24 | MP0005499_abnormal_olfactory_system | 1.73150116 |
| 25 | MP0005394_taste/olfaction_phenotype | 1.73150116 |
| 26 | MP0002102_abnormal_ear_morphology | 1.73062414 |
| 27 | MP0005174_abnormal_tail_pigmentation | 1.71930931 |
| 28 | MP0005551_abnormal_eye_electrophysiolog | 1.60488060 |
| 29 | MP0006276_abnormal_autonomic_nervous | 1.51790343 |
| 30 | MP0004036_abnormal_muscle_relaxation | 1.51511691 |
| 31 | MP0008875_abnormal_xenobiotic_pharmacok | 1.48032932 |
| 32 | MP0000631_abnormal_neuroendocrine_gland | 1.47888410 |
| 33 | MP0003879_abnormal_hair_cell | 1.47834937 |
| 34 | MP0002148_abnormal_hypersensitivity_rea | 1.47270120 |
| 35 | MP0008057_abnormal_DNA_replication | 1.42804116 |
| 36 | MP0002234_abnormal_pharynx_morphology | 1.33839329 |
| 37 | MP0003763_abnormal_thymus_physiology | 1.33324252 |
| 38 | MP0005389_reproductive_system_phenotype | 1.33019256 |
| 39 | MP0002876_abnormal_thyroid_physiology | 1.32221918 |
| 40 | MP0004885_abnormal_endolymph | 1.31455212 |
| 41 | MP0002160_abnormal_reproductive_system | 1.25775511 |
| 42 | MP0005379_endocrine/exocrine_gland_phen | 1.20698194 |
| 43 | MP0001348_abnormal_lacrimal_gland | 1.18114887 |
| 44 | MP0003880_abnormal_central_pattern | 1.17693938 |
| 45 | MP0002138_abnormal_hepatobiliary_system | 1.16555275 |
| 46 | MP0005645_abnormal_hypothalamus_physiol | 1.16541988 |
| 47 | MP0001968_abnormal_touch/_nociception | 1.16050752 |
| 48 | MP0005253_abnormal_eye_physiology | 1.13142177 |
| 49 | MP0001919_abnormal_reproductive_system | 1.10340492 |
| 50 | MP0001800_abnormal_humoral_immune | 1.09875334 |
| 51 | MP0002272_abnormal_nervous_system | 1.07605348 |
| 52 | MP0000685_abnormal_immune_system | 1.07434888 |
| 53 | MP0006036_abnormal_mitochondrial_physio | 1.06752420 |
| 54 | MP0001663_abnormal_digestive_system | 1.05814952 |
| 55 | MP0003119_abnormal_digestive_system | 1.03848403 |
| 56 | MP0002723_abnormal_immune_serum | 1.02287992 |
| 57 | MP0009745_abnormal_behavioral_response | 0.98357382 |
| 58 | MP0001873_stomach_inflammation | 0.97857845 |
| 59 | MP0009780_abnormal_chondrocyte_physiolo | 0.96652304 |
| 60 | MP0003137_abnormal_impulse_conducting | 0.95686033 |
| 61 | MP0002095_abnormal_skin_pigmentation | 0.91106088 |
| 62 | MP0010386_abnormal_urinary_bladder | 0.90559050 |
| 63 | MP0002277_abnormal_respiratory_mucosa | 0.90167209 |
| 64 | MP0000467_abnormal_esophagus_morphology | 0.90013838 |
| 65 | MP0002006_tumorigenesis | 0.89862541 |
| 66 | MP0009764_decreased_sensitivity_to | 0.89107974 |
| 67 | MP0005646_abnormal_pituitary_gland | 0.87992496 |
| 68 | MP0002166_altered_tumor_susceptibility | 0.87616647 |
| 69 | MP0005000_abnormal_immune_tolerance | 0.86508476 |
| 70 | MP0001853_heart_inflammation | 0.86450728 |
| 71 | MP0003787_abnormal_imprinting | 0.86416020 |
| 72 | MP0002938_white_spotting | 0.86398724 |
| 73 | MP0008775_abnormal_heart_ventricle | 0.85655152 |
| 74 | MP0001905_abnormal_dopamine_level | 0.85297353 |
| 75 | MP0008058_abnormal_DNA_repair | 0.85209988 |
| 76 | MP0004043_abnormal_pH_regulation | 0.84313552 |
| 77 | MP0001970_abnormal_pain_threshold | 0.82283703 |
| 78 | MP0001486_abnormal_startle_reflex | 0.81465791 |
| 79 | MP0002210_abnormal_sex_determination | 0.80649559 |
| 80 | MP0002736_abnormal_nociception_after | 0.76963029 |
| 81 | MP0000049_abnormal_middle_ear | 0.75173365 |
| 82 | MP0002184_abnormal_innervation | 0.75155980 |
| 83 | MP0002751_abnormal_autonomic_nervous | 0.74288183 |
| 84 | MP0009046_muscle_twitch | 0.73717417 |
| 85 | MP0003633_abnormal_nervous_system | 0.73037212 |
| 86 | MP0010329_abnormal_lipoprotein_level | 0.72842046 |
| 87 | MP0001485_abnormal_pinna_reflex | 0.71089894 |
| 88 | MP0002420_abnormal_adaptive_immunity | 0.69936195 |
| 89 | MP0003122_maternal_imprinting | 0.69447700 |
| 90 | MP0001293_anophthalmia | 0.69385231 |
| 91 | MP0004130_abnormal_muscle_cell | 0.69337900 |
| 92 | MP0001502_abnormal_circadian_rhythm | 0.68709988 |
| 93 | MP0001440_abnormal_grooming_behavior | 0.68339717 |
| 94 | MP0001501_abnormal_sleep_pattern | 0.68224550 |
| 95 | MP0001819_abnormal_immune_cell | 0.67188009 |
| 96 | MP0001119_abnormal_female_reproductive | 0.66952181 |
| 97 | MP0002733_abnormal_thermal_nociception | 0.66014120 |
| 98 | MP0005085_abnormal_gallbladder_physiolo | 0.63859629 |
| 99 | MP0000604_amyloidosis | 0.63389645 |
| 100 | MP0003718_maternal_effect | 0.63260766 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Lipid accumulation in hepatocytes (HP:0006561) | 5.13046333 |
| 2 | Reticulocytopenia (HP:0001896) | 4.60444214 |
| 3 | Colon cancer (HP:0003003) | 4.36247361 |
| 4 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.01178256 |
| 5 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.01178256 |
| 6 | Abnormality of midbrain morphology (HP:0002418) | 3.72880405 |
| 7 | Molar tooth sign on MRI (HP:0002419) | 3.72880405 |
| 8 | Increased muscle lipid content (HP:0009058) | 3.68951604 |
| 9 | Methylmalonic aciduria (HP:0012120) | 3.53231402 |
| 10 | Acute necrotizing encephalopathy (HP:0006965) | 3.49100343 |
| 11 | Stomatitis (HP:0010280) | 3.47138971 |
| 12 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.22532936 |
| 13 | IgG deficiency (HP:0004315) | 3.22274638 |
| 14 | Macrocytic anemia (HP:0001972) | 3.21918828 |
| 15 | Acute encephalopathy (HP:0006846) | 3.14291261 |
| 16 | Increased IgM level (HP:0003496) | 3.09421394 |
| 17 | Methylmalonic acidemia (HP:0002912) | 3.06176636 |
| 18 | Panhypogammaglobulinemia (HP:0003139) | 3.05479745 |
| 19 | Mitochondrial inheritance (HP:0001427) | 3.04648297 |
| 20 | Pallor (HP:0000980) | 3.01864839 |
| 21 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.01185005 |
| 22 | Progressive macrocephaly (HP:0004481) | 2.97282413 |
| 23 | Congenital, generalized hypertrichosis (HP:0004540) | 2.89866585 |
| 24 | Parakeratosis (HP:0001036) | 2.81778697 |
| 25 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.78146051 |
| 26 | Congenital stationary night blindness (HP:0007642) | 2.78141677 |
| 27 | Hip dysplasia (HP:0001385) | 2.73136490 |
| 28 | Increased hepatocellular lipid droplets (HP:0006565) | 2.71868017 |
| 29 | Increased CSF lactate (HP:0002490) | 2.68468730 |
| 30 | Progressive inability to walk (HP:0002505) | 2.62562496 |
| 31 | Polydipsia (HP:0001959) | 2.59538831 |
| 32 | Abnormal drinking behavior (HP:0030082) | 2.59538831 |
| 33 | Conjugated hyperbilirubinemia (HP:0002908) | 2.53607259 |
| 34 | Hepatocellular necrosis (HP:0001404) | 2.53352437 |
| 35 | Nephronophthisis (HP:0000090) | 2.53129751 |
| 36 | Nephrogenic diabetes insipidus (HP:0009806) | 2.52825049 |
| 37 | Abnormality of DNA repair (HP:0003254) | 2.48270270 |
| 38 | 3-Methylglutaconic aciduria (HP:0003535) | 2.46819877 |
| 39 | Pancreatic cysts (HP:0001737) | 2.45781454 |
| 40 | Dicarboxylic aciduria (HP:0003215) | 2.45271169 |
| 41 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.45271169 |
| 42 | Respiratory failure (HP:0002878) | 2.43219362 |
| 43 | Absent thumb (HP:0009777) | 2.42002419 |
| 44 | Spastic paraparesis (HP:0002313) | 2.41900048 |
| 45 | Mutism (HP:0002300) | 2.40422583 |
| 46 | Abnormal number of erythroid precursors (HP:0012131) | 2.40257461 |
| 47 | Type 2 muscle fiber atrophy (HP:0003554) | 2.37225337 |
| 48 | Type II lissencephaly (HP:0007260) | 2.37037346 |
| 49 | Abnormality of T cell physiology (HP:0011840) | 2.35808344 |
| 50 | Poor suck (HP:0002033) | 2.25014934 |
| 51 | Amniotic constriction ring (HP:0009775) | 2.19368336 |
| 52 | Abnormality of placental membranes (HP:0011409) | 2.19368336 |
| 53 | Polyuria (HP:0000103) | 2.18539805 |
| 54 | Ureteral duplication (HP:0000073) | 2.10277806 |
| 55 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.07462647 |
| 56 | Increased intramyocellular lipid droplets (HP:0012240) | 2.07234346 |
| 57 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.06733922 |
| 58 | Muscle fiber atrophy (HP:0100295) | 2.06730995 |
| 59 | Medial flaring of the eyebrow (HP:0010747) | 2.05613440 |
| 60 | Pancreatic fibrosis (HP:0100732) | 2.03663233 |
| 61 | Leukodystrophy (HP:0002415) | 2.03590874 |
| 62 | Renal Fanconi syndrome (HP:0001994) | 2.01135559 |
| 63 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.99774185 |
| 64 | Recurrent cutaneous fungal infections (HP:0011370) | 1.99774185 |
| 65 | Inability to walk (HP:0002540) | 1.99682316 |
| 66 | Agammaglobulinemia (HP:0004432) | 1.98485602 |
| 67 | Hyperglycinemia (HP:0002154) | 1.97589252 |
| 68 | Cerebral hemorrhage (HP:0001342) | 1.97207602 |
| 69 | Porencephaly (HP:0002132) | 1.95111993 |
| 70 | Cerebral edema (HP:0002181) | 1.95093388 |
| 71 | Enlarged kidneys (HP:0000105) | 1.92997787 |
| 72 | Hypomagnesemia (HP:0002917) | 1.90933380 |
| 73 | Facial diplegia (HP:0001349) | 1.90785633 |
| 74 | Hepatic necrosis (HP:0002605) | 1.90553196 |
| 75 | Optic disc pallor (HP:0000543) | 1.90288198 |
| 76 | Muscle hypertrophy of the lower extremities (HP:0008968) | 1.90207349 |
| 77 | Stenosis of the external auditory canal (HP:0000402) | 1.89875396 |
| 78 | Lethargy (HP:0001254) | 1.89843675 |
| 79 | Abolished electroretinogram (ERG) (HP:0000550) | 1.88633923 |
| 80 | Polyphagia (HP:0002591) | 1.88365641 |
| 81 | Hematochezia (HP:0002573) | 1.88198160 |
| 82 | Hypoplasia of the ulna (HP:0003022) | 1.87070494 |
| 83 | Congenital sensorineural hearing impairment (HP:0008527) | 1.85121036 |
| 84 | Lactic acidosis (HP:0003128) | 1.84043804 |
| 85 | Abnormality of the renal collecting system (HP:0004742) | 1.83344106 |
| 86 | Abnormality of the renal medulla (HP:0100957) | 1.83018255 |
| 87 | Tubulointerstitial nephritis (HP:0001970) | 1.82972998 |
| 88 | Neutropenia (HP:0001875) | 1.81805469 |
| 89 | Congenital primary aphakia (HP:0007707) | 1.80371928 |
| 90 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.80162145 |
| 91 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.79686546 |
| 92 | Abnormal urine output (HP:0012590) | 1.79284863 |
| 93 | Wide intermamillary distance (HP:0006610) | 1.78128814 |
| 94 | Abnormality of T cells (HP:0002843) | 1.77081245 |
| 95 | Exertional dyspnea (HP:0002875) | 1.76671253 |
| 96 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.75713412 |
| 97 | Gait imbalance (HP:0002141) | 1.75154821 |
| 98 | Pendular nystagmus (HP:0012043) | 1.75144231 |
| 99 | Median cleft lip (HP:0000161) | 1.74309196 |
| 100 | Chorioretinal atrophy (HP:0000533) | 1.72432168 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ERN1 | 4.51039382 |
| 2 | ADRBK2 | 4.23243270 |
| 3 | TRIM28 | 4.16119292 |
| 4 | WNK4 | 3.49850309 |
| 5 | TXK | 3.09781725 |
| 6 | MAP2K2 | 2.91318376 |
| 7 | CDK19 | 2.68074189 |
| 8 | STK39 | 2.32601484 |
| 9 | NEK1 | 2.31843892 |
| 10 | DYRK2 | 2.11926640 |
| 11 | FRK | 2.03344746 |
| 12 | STK16 | 1.93103849 |
| 13 | NLK | 1.89454654 |
| 14 | DAPK2 | 1.79866139 |
| 15 | IKBKE | 1.75269117 |
| 16 | LRRK2 | 1.74695442 |
| 17 | WNK3 | 1.66274143 |
| 18 | CSNK1G3 | 1.53112400 |
| 19 | MAP4K1 | 1.51384361 |
| 20 | GRK1 | 1.44743909 |
| 21 | SCYL2 | 1.42518568 |
| 22 | ADRBK1 | 1.42068982 |
| 23 | CSNK1A1L | 1.41776354 |
| 24 | NUAK1 | 1.30459849 |
| 25 | IRAK2 | 1.29496212 |
| 26 | MUSK | 1.28938322 |
| 27 | CSNK1G1 | 1.26377065 |
| 28 | CSNK1G2 | 1.25679788 |
| 29 | TEC | 1.24974465 |
| 30 | MAP4K2 | 1.15088885 |
| 31 | EIF2AK1 | 1.09930228 |
| 32 | TLK1 | 1.08983238 |
| 33 | OXSR1 | 1.04659952 |
| 34 | MAPK13 | 1.01361239 |
| 35 | MST4 | 1.00584456 |
| 36 | IKBKB | 0.98649283 |
| 37 | INSRR | 0.97481579 |
| 38 | PINK1 | 0.97416333 |
| 39 | SYK | 0.96963932 |
| 40 | MAP2K6 | 0.91057172 |
| 41 | STK11 | 0.86388437 |
| 42 | ZAK | 0.85808872 |
| 43 | FLT3 | 0.84810201 |
| 44 | KIT | 0.84754746 |
| 45 | PIK3CA | 0.83771320 |
| 46 | RPS6KA5 | 0.81235877 |
| 47 | GRK7 | 0.79038728 |
| 48 | MAP3K12 | 0.73736747 |
| 49 | CSNK2A2 | 0.71172464 |
| 50 | PASK | 0.70458992 |
| 51 | BCKDK | 0.69593830 |
| 52 | CSF1R | 0.67626173 |
| 53 | CDC7 | 0.66880207 |
| 54 | PRKCQ | 0.66619197 |
| 55 | MAP2K1 | 0.65132273 |
| 56 | MARK3 | 0.62774398 |
| 57 | ITK | 0.61301083 |
| 58 | OBSCN | 0.60199934 |
| 59 | PAK3 | 0.59537820 |
| 60 | NME1 | 0.58586085 |
| 61 | MAP3K4 | 0.56969362 |
| 62 | LYN | 0.54951220 |
| 63 | PIM1 | 0.51867941 |
| 64 | TBK1 | 0.50945146 |
| 65 | PRKCE | 0.49581843 |
| 66 | TIE1 | 0.48874063 |
| 67 | MYLK | 0.47850096 |
| 68 | YES1 | 0.47826557 |
| 69 | JAK3 | 0.47544009 |
| 70 | PRKACA | 0.46994829 |
| 71 | EIF2AK3 | 0.46915037 |
| 72 | TSSK6 | 0.46382837 |
| 73 | STK10 | 0.46146157 |
| 74 | CSNK1E | 0.45683193 |
| 75 | CSNK2A1 | 0.45409223 |
| 76 | CSNK1A1 | 0.45204896 |
| 77 | PHKG2 | 0.44698336 |
| 78 | PHKG1 | 0.44698336 |
| 79 | LCK | 0.44538718 |
| 80 | PNCK | 0.44403122 |
| 81 | STK24 | 0.44138663 |
| 82 | ABL1 | 0.43466524 |
| 83 | NEK2 | 0.42525378 |
| 84 | MINK1 | 0.41270706 |
| 85 | BTK | 0.40431666 |
| 86 | MAP2K4 | 0.40128823 |
| 87 | DAPK3 | 0.39110549 |
| 88 | CCNB1 | 0.38460589 |
| 89 | PRKCA | 0.38424666 |
| 90 | DYRK1A | 0.37537180 |
| 91 | TAOK3 | 0.37152052 |
| 92 | MKNK2 | 0.36116623 |
| 93 | ATR | 0.35908732 |
| 94 | FES | 0.34775764 |
| 95 | PLK4 | 0.34721572 |
| 96 | PRKCG | 0.33954136 |
| 97 | MAP3K8 | 0.33844186 |
| 98 | CSNK1D | 0.33434478 |
| 99 | MELK | 0.32920332 |
| 100 | MAPK3 | 0.32281408 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.65470355 |
| 2 | Asthma_Homo sapiens_hsa05310 | 4.56634120 |
| 3 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 4.29389463 |
| 4 | Allograft rejection_Homo sapiens_hsa05330 | 3.68560192 |
| 5 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.53175866 |
| 6 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 3.06071113 |
| 7 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.82921076 |
| 8 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.69510670 |
| 9 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.50191249 |
| 10 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.47787305 |
| 11 | Protein export_Homo sapiens_hsa03060 | 2.44930655 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.13836855 |
| 13 | Parkinsons disease_Homo sapiens_hsa05012 | 1.90866962 |
| 14 | Viral myocarditis_Homo sapiens_hsa05416 | 1.85848565 |
| 15 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.77187683 |
| 16 | Sulfur relay system_Homo sapiens_hsa04122 | 1.63334880 |
| 17 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.60985920 |
| 18 | Proteasome_Homo sapiens_hsa03050 | 1.45822126 |
| 19 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.42616649 |
| 20 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.39609926 |
| 21 | Alzheimers disease_Homo sapiens_hsa05010 | 1.38847792 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.35602436 |
| 23 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.29848374 |
| 24 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.25556049 |
| 25 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.25491501 |
| 26 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.23190573 |
| 27 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.21903847 |
| 28 | Olfactory transduction_Homo sapiens_hsa04740 | 1.20058794 |
| 29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.15633403 |
| 30 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.13944994 |
| 31 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.10122536 |
| 32 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.08991341 |
| 33 | RNA polymerase_Homo sapiens_hsa03020 | 1.04463940 |
| 34 | Phototransduction_Homo sapiens_hsa04744 | 1.04454285 |
| 35 | Nicotine addiction_Homo sapiens_hsa05033 | 0.99667986 |
| 36 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.98836858 |
| 37 | Homologous recombination_Homo sapiens_hsa03440 | 0.98359296 |
| 38 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.96652220 |
| 39 | Mismatch repair_Homo sapiens_hsa03430 | 0.96603128 |
| 40 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.94220304 |
| 41 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.93561657 |
| 42 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.92967553 |
| 43 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.92937398 |
| 44 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.87871518 |
| 45 | RNA degradation_Homo sapiens_hsa03018 | 0.83229823 |
| 46 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.82351561 |
| 47 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.80803539 |
| 48 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.80445662 |
| 49 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.74091264 |
| 50 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.71534149 |
| 51 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.66042989 |
| 52 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.65177890 |
| 53 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.64761782 |
| 54 | DNA replication_Homo sapiens_hsa03030 | 0.64472384 |
| 55 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.63572388 |
| 56 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.62782270 |
| 57 | RNA transport_Homo sapiens_hsa03013 | 0.61377641 |
| 58 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.61309267 |
| 59 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.60259875 |
| 60 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.59307999 |
| 61 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.55504593 |
| 62 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.55361912 |
| 63 | GABAergic synapse_Homo sapiens_hsa04727 | 0.53548112 |
| 64 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.53534560 |
| 65 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.53417007 |
| 66 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.53389813 |
| 67 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.52415195 |
| 68 | Morphine addiction_Homo sapiens_hsa05032 | 0.51751661 |
| 69 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.47230512 |
| 70 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.45530430 |
| 71 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.43923307 |
| 72 | Base excision repair_Homo sapiens_hsa03410 | 0.42869033 |
| 73 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.41939339 |
| 74 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.40843371 |
| 75 | Circadian entrainment_Homo sapiens_hsa04713 | 0.40817352 |
| 76 | Retinol metabolism_Homo sapiens_hsa00830 | 0.40690825 |
| 77 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.39128967 |
| 78 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.39080712 |
| 79 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.38729068 |
| 80 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.37911890 |
| 81 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.35656140 |
| 82 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.35585333 |
| 83 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.35512437 |
| 84 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.35133062 |
| 85 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.34646662 |
| 86 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.33555112 |
| 87 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.33043425 |
| 88 | Metabolic pathways_Homo sapiens_hsa01100 | 0.31804941 |
| 89 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.31580208 |
| 90 | Taste transduction_Homo sapiens_hsa04742 | 0.30898760 |
| 91 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.30448967 |
| 92 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.30380922 |
| 93 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.30265038 |
| 94 | Leishmaniasis_Homo sapiens_hsa05140 | 0.28770927 |
| 95 | Purine metabolism_Homo sapiens_hsa00230 | 0.28309296 |
| 96 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.27469528 |
| 97 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.25922119 |
| 98 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.25068218 |
| 99 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.24616495 |
| 100 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.24531907 |

