RPL21P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)7.57264044
2chaperone-mediated protein transport (GO:0072321)7.38808393
3preassembly of GPI anchor in ER membrane (GO:0016254)6.75819069
4viral transcription (GO:0019083)6.38852900
5translational termination (GO:0006415)6.12256444
6ribosomal small subunit assembly (GO:0000028)5.45102808
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.41852160
8cotranslational protein targeting to membrane (GO:0006613)5.29699251
9protein targeting to ER (GO:0045047)5.25953795
10ribosomal small subunit biogenesis (GO:0042274)5.25391773
11translational elongation (GO:0006414)5.11661432
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.02248375
13protein localization to endoplasmic reticulum (GO:0070972)4.92220029
14GPI anchor biosynthetic process (GO:0006506)4.90020626
15positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.71969690
16viral life cycle (GO:0019058)4.69230364
17GPI anchor metabolic process (GO:0006505)4.56027469
18cellular protein complex disassembly (GO:0043624)4.49971956
19translational initiation (GO:0006413)4.45790665
20regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.45187953
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.42160737
22regulation of immunoglobulin secretion (GO:0051023)4.40679651
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.38514180
24DNA deamination (GO:0045006)4.25977977
25maturation of SSU-rRNA (GO:0030490)4.22004228
26peptidyl-histidine modification (GO:0018202)4.07898912
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.98357361
28ATP synthesis coupled proton transport (GO:0015986)3.98046184
29energy coupled proton transport, down electrochemical gradient (GO:0015985)3.98046184
30intracellular protein transmembrane import (GO:0044743)3.95601100
31receptor guanylyl cyclase signaling pathway (GO:0007168)3.93052606
32water-soluble vitamin biosynthetic process (GO:0042364)3.87342709
33C-terminal protein lipidation (GO:0006501)3.86365001
34ribosomal large subunit biogenesis (GO:0042273)3.76316257
35translation (GO:0006412)3.72630388
36protein complex disassembly (GO:0043241)3.72371988
37behavioral response to ethanol (GO:0048149)3.64258521
38positive regulation of isotype switching (GO:0045830)3.62772630
39behavioral response to nicotine (GO:0035095)3.61286074
40C-terminal protein amino acid modification (GO:0018410)3.60905504
41protein targeting to mitochondrion (GO:0006626)3.58273250
42protein complex biogenesis (GO:0070271)3.57808410
43regulation of regulatory T cell differentiation (GO:0045589)3.57242034
44pyrimidine nucleotide catabolic process (GO:0006244)3.54807364
45positive regulation of DNA recombination (GO:0045911)3.49234535
46meiotic chromosome segregation (GO:0045132)3.46657828
47macromolecular complex disassembly (GO:0032984)3.43100794
48inner mitochondrial membrane organization (GO:0007007)3.41695504
49mitochondrial respiratory chain complex assembly (GO:0033108)3.40292233
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.34960220
51establishment of protein localization to mitochondrion (GO:0072655)3.32464936
52protein targeting to membrane (GO:0006612)3.29505861
53regulation of isotype switching to IgG isotypes (GO:0048302)3.26060619
54regulation of RIG-I signaling pathway (GO:0039535)3.25353426
55regulation of memory T cell differentiation (GO:0043380)3.24631375
56protein localization to mitochondrion (GO:0070585)3.23096268
57behavioral defense response (GO:0002209)3.22199183
58behavioral fear response (GO:0001662)3.22199183
59male meiosis I (GO:0007141)3.20880163
60intracellular protein transmembrane transport (GO:0065002)3.19912790
61mitochondrial calcium ion transport (GO:0006851)3.19696209
62rRNA processing (GO:0006364)3.18790807
63rRNA metabolic process (GO:0016072)3.13142421
64piRNA metabolic process (GO:0034587)3.08216559
65regulation of chronic inflammatory response (GO:0002676)3.07142913
66nuclear-transcribed mRNA catabolic process (GO:0000956)3.05403342
67protein transmembrane transport (GO:0071806)2.99028328
68pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96999468
69kynurenine metabolic process (GO:0070189)2.96536046
70glycolipid biosynthetic process (GO:0009247)2.94961827
71DNA methylation involved in gamete generation (GO:0043046)2.94410973
72positive regulation of prostaglandin secretion (GO:0032308)2.91940389
73cell wall macromolecule catabolic process (GO:0016998)2.89804100
74mitochondrial respiratory chain complex I assembly (GO:0032981)2.89790707
75NADH dehydrogenase complex assembly (GO:0010257)2.89790707
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89790707
77positive regulation of B cell mediated immunity (GO:0002714)2.89130633
78positive regulation of immunoglobulin mediated immune response (GO:0002891)2.89130633
79positive regulation of cell fate commitment (GO:0010455)2.87199343
80mRNA catabolic process (GO:0006402)2.86158630
81mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84746129
82mannosylation (GO:0097502)2.83380031
83proteasome assembly (GO:0043248)2.82721958
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81178679
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81178679
86ribonucleoprotein complex biogenesis (GO:0022613)2.78632039
87fear response (GO:0042596)2.78412882
88regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.78004201
89cellular component biogenesis (GO:0044085)2.74316292
90positive regulation of sodium ion transmembrane transport (GO:1902307)2.73592823
91positive regulation of activated T cell proliferation (GO:0042104)2.72354727
92indole-containing compound catabolic process (GO:0042436)2.68442144
93indolalkylamine catabolic process (GO:0046218)2.68442144
94tryptophan catabolic process (GO:0006569)2.68442144
95positive regulation of fatty acid transport (GO:2000193)2.68356791
96protein neddylation (GO:0045116)2.67193974
97opioid receptor signaling pathway (GO:0038003)2.65133533
98positive regulation of immunoglobulin production (GO:0002639)2.65107711
99mitochondrial transport (GO:0006839)2.63231709
100cornea development in camera-type eye (GO:0061303)2.60931143

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.95321065
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.11244587
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97724533
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83228126
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.78206616
6EZH2_22144423_ChIP-Seq_EOC_Human2.61978656
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.56355350
8IRF1_19129219_ChIP-ChIP_H3396_Human2.46312859
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.43508161
10YY1_21170310_ChIP-Seq_MESCs_Mouse2.41535557
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.38045949
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.36741084
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.33495612
14ELK1_19687146_ChIP-ChIP_HELA_Human2.32383799
15VDR_23849224_ChIP-Seq_CD4+_Human2.28160904
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17819802
17TP53_22573176_ChIP-Seq_HFKS_Human2.04425427
18MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human2.04306651
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03830545
20VDR_22108803_ChIP-Seq_LS180_Human1.99816242
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97758278
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.93938455
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.89284063
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86409403
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79943461
26MYC_18940864_ChIP-ChIP_HL60_Human1.72565046
27NANOG_19829295_ChIP-Seq_ESCs_Human1.70387490
28SOX2_19829295_ChIP-Seq_ESCs_Human1.70387490
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63107660
30RNF2_27304074_Chip-Seq_NSC_Mouse1.57414871
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56294996
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53948421
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52277181
34GATA3_21878914_ChIP-Seq_MCF-7_Human1.49398771
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47601226
36EWS_26573619_Chip-Seq_HEK293_Human1.46474090
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43017071
38GBX2_23144817_ChIP-Seq_PC3_Human1.42162714
39FOXP3_21729870_ChIP-Seq_TREG_Human1.39435856
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39042983
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37701322
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37596483
43HTT_18923047_ChIP-ChIP_STHdh_Human1.35010665
44NANOG_20526341_ChIP-Seq_ESCs_Human1.33289332
45GATA3_26560356_Chip-Seq_TH2_Human1.33245763
46EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.32574483
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.30439685
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30186361
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.28431242
50MYC_19829295_ChIP-Seq_ESCs_Human1.26609150
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25949382
52STAT1_20625510_ChIP-Seq_HELA_Human1.25454157
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.25025565
54CIITA_25753668_ChIP-Seq_RAJI_Human1.24581425
55CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24474270
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.24412523
57FOXH1_21741376_ChIP-Seq_EPCs_Human1.23933301
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23849670
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23244631
60ER_23166858_ChIP-Seq_MCF-7_Human1.22926748
61TTF2_22483619_ChIP-Seq_HELA_Human1.18991038
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17927579
63P300_19829295_ChIP-Seq_ESCs_Human1.17702033
64GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.17003252
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.15398424
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15398424
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13204126
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11277720
69RAC3_21632823_ChIP-Seq_H3396_Human1.10821207
70TAF15_26573619_Chip-Seq_HEK293_Human1.10614753
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10144947
72CBP_20019798_ChIP-Seq_JUKART_Human1.10116017
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10116017
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10035998
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.09739366
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08835723
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.07566097
78E2F1_20622854_ChIP-Seq_HELA_Human1.07242155
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07141321
80GATA3_27048872_Chip-Seq_THYMUS_Human1.05817764
81P300_27268052_Chip-Seq_Bcells_Human1.03323550
82AR_20517297_ChIP-Seq_VCAP_Human1.02546843
83OCT4_20526341_ChIP-Seq_ESCs_Human1.01632853
84FUS_26573619_Chip-Seq_HEK293_Human1.00860109
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99567902
86IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99267998
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98382222
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98163676
89EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97263625
90HOXB7_26014856_ChIP-Seq_BT474_Human0.96116687
91CTCF_20526341_ChIP-Seq_ESCs_Human0.94940628
92JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94498163
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93522180
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92751539
95EZH2_27294783_Chip-Seq_ESCs_Mouse0.92750759
96TAF2_19829295_ChIP-Seq_ESCs_Human0.91544494
97CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91204564
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89815788
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88796546
100ERA_21632823_ChIP-Seq_H3396_Human0.88765040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.98827776
2MP0003646_muscle_fatigue4.82595980
3MP0003011_delayed_dark_adaptation3.44481096
4MP0006292_abnormal_olfactory_placode3.43612897
5MP0001835_abnormal_antigen_presentation2.86860802
6MP0008877_abnormal_DNA_methylation2.79185160
7MP0005670_abnormal_white_adipose2.51043100
8MP0008789_abnormal_olfactory_epithelium2.46639201
9MP0003786_premature_aging2.32349879
10MP0002163_abnormal_gland_morphology2.31247394
11MP0004145_abnormal_muscle_electrophysio2.30941033
12MP0002837_dystrophic_cardiac_calcinosis2.21893197
13MP0001986_abnormal_taste_sensitivity2.19728642
14MP0003806_abnormal_nucleotide_metabolis2.04879110
15MP0003195_calcinosis2.02541447
16MP0002909_abnormal_adrenal_gland2.01753890
17MP0005671_abnormal_response_to2.01502401
18MP0006072_abnormal_retinal_apoptosis1.93845827
19MP0000372_irregular_coat_pigmentation1.86232669
20MP0005387_immune_system_phenotype1.80560073
21MP0001790_abnormal_immune_system1.80560073
22MP0004142_abnormal_muscle_tone1.79889245
23MP0008872_abnormal_physiological_respon1.77873069
24MP0005499_abnormal_olfactory_system1.73150116
25MP0005394_taste/olfaction_phenotype1.73150116
26MP0002102_abnormal_ear_morphology1.73062414
27MP0005174_abnormal_tail_pigmentation1.71930931
28MP0005551_abnormal_eye_electrophysiolog1.60488060
29MP0006276_abnormal_autonomic_nervous1.51790343
30MP0004036_abnormal_muscle_relaxation1.51511691
31MP0008875_abnormal_xenobiotic_pharmacok1.48032932
32MP0000631_abnormal_neuroendocrine_gland1.47888410
33MP0003879_abnormal_hair_cell1.47834937
34MP0002148_abnormal_hypersensitivity_rea1.47270120
35MP0008057_abnormal_DNA_replication1.42804116
36MP0002234_abnormal_pharynx_morphology1.33839329
37MP0003763_abnormal_thymus_physiology1.33324252
38MP0005389_reproductive_system_phenotype1.33019256
39MP0002876_abnormal_thyroid_physiology1.32221918
40MP0004885_abnormal_endolymph1.31455212
41MP0002160_abnormal_reproductive_system1.25775511
42MP0005379_endocrine/exocrine_gland_phen1.20698194
43MP0001348_abnormal_lacrimal_gland1.18114887
44MP0003880_abnormal_central_pattern1.17693938
45MP0002138_abnormal_hepatobiliary_system1.16555275
46MP0005645_abnormal_hypothalamus_physiol1.16541988
47MP0001968_abnormal_touch/_nociception1.16050752
48MP0005253_abnormal_eye_physiology1.13142177
49MP0001919_abnormal_reproductive_system1.10340492
50MP0001800_abnormal_humoral_immune1.09875334
51MP0002272_abnormal_nervous_system1.07605348
52MP0000685_abnormal_immune_system1.07434888
53MP0006036_abnormal_mitochondrial_physio1.06752420
54MP0001663_abnormal_digestive_system1.05814952
55MP0003119_abnormal_digestive_system1.03848403
56MP0002723_abnormal_immune_serum1.02287992
57MP0009745_abnormal_behavioral_response0.98357382
58MP0001873_stomach_inflammation0.97857845
59MP0009780_abnormal_chondrocyte_physiolo0.96652304
60MP0003137_abnormal_impulse_conducting0.95686033
61MP0002095_abnormal_skin_pigmentation0.91106088
62MP0010386_abnormal_urinary_bladder0.90559050
63MP0002277_abnormal_respiratory_mucosa0.90167209
64MP0000467_abnormal_esophagus_morphology0.90013838
65MP0002006_tumorigenesis0.89862541
66MP0009764_decreased_sensitivity_to0.89107974
67MP0005646_abnormal_pituitary_gland0.87992496
68MP0002166_altered_tumor_susceptibility0.87616647
69MP0005000_abnormal_immune_tolerance0.86508476
70MP0001853_heart_inflammation0.86450728
71MP0003787_abnormal_imprinting0.86416020
72MP0002938_white_spotting0.86398724
73MP0008775_abnormal_heart_ventricle0.85655152
74MP0001905_abnormal_dopamine_level0.85297353
75MP0008058_abnormal_DNA_repair0.85209988
76MP0004043_abnormal_pH_regulation0.84313552
77MP0001970_abnormal_pain_threshold0.82283703
78MP0001486_abnormal_startle_reflex0.81465791
79MP0002210_abnormal_sex_determination0.80649559
80MP0002736_abnormal_nociception_after0.76963029
81MP0000049_abnormal_middle_ear0.75173365
82MP0002184_abnormal_innervation0.75155980
83MP0002751_abnormal_autonomic_nervous0.74288183
84MP0009046_muscle_twitch0.73717417
85MP0003633_abnormal_nervous_system0.73037212
86MP0010329_abnormal_lipoprotein_level0.72842046
87MP0001485_abnormal_pinna_reflex0.71089894
88MP0002420_abnormal_adaptive_immunity0.69936195
89MP0003122_maternal_imprinting0.69447700
90MP0001293_anophthalmia0.69385231
91MP0004130_abnormal_muscle_cell0.69337900
92MP0001502_abnormal_circadian_rhythm0.68709988
93MP0001440_abnormal_grooming_behavior0.68339717
94MP0001501_abnormal_sleep_pattern0.68224550
95MP0001819_abnormal_immune_cell0.67188009
96MP0001119_abnormal_female_reproductive0.66952181
97MP0002733_abnormal_thermal_nociception0.66014120
98MP0005085_abnormal_gallbladder_physiolo0.63859629
99MP0000604_amyloidosis0.63389645
100MP0003718_maternal_effect0.63260766

Predicted human phenotypes

RankGene SetZ-score
1Lipid accumulation in hepatocytes (HP:0006561)5.13046333
2Reticulocytopenia (HP:0001896)4.60444214
3Colon cancer (HP:0003003)4.36247361
4Decreased activity of mitochondrial respiratory chain (HP:0008972)4.01178256
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.01178256
6Abnormality of midbrain morphology (HP:0002418)3.72880405
7Molar tooth sign on MRI (HP:0002419)3.72880405
8Increased muscle lipid content (HP:0009058)3.68951604
9Methylmalonic aciduria (HP:0012120)3.53231402
10Acute necrotizing encephalopathy (HP:0006965)3.49100343
11Stomatitis (HP:0010280)3.47138971
12Abnormality of cells of the erythroid lineage (HP:0012130)3.22532936
13IgG deficiency (HP:0004315)3.22274638
14Macrocytic anemia (HP:0001972)3.21918828
15Acute encephalopathy (HP:0006846)3.14291261
16Increased IgM level (HP:0003496)3.09421394
17Methylmalonic acidemia (HP:0002912)3.06176636
18Panhypogammaglobulinemia (HP:0003139)3.05479745
19Mitochondrial inheritance (HP:0001427)3.04648297
20Pallor (HP:0000980)3.01864839
21Abnormal mitochondria in muscle tissue (HP:0008316)3.01185005
22Progressive macrocephaly (HP:0004481)2.97282413
23Congenital, generalized hypertrichosis (HP:0004540)2.89866585
24Parakeratosis (HP:0001036)2.81778697
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.78146051
26Congenital stationary night blindness (HP:0007642)2.78141677
27Hip dysplasia (HP:0001385)2.73136490
28Increased hepatocellular lipid droplets (HP:0006565)2.71868017
29Increased CSF lactate (HP:0002490)2.68468730
30Progressive inability to walk (HP:0002505)2.62562496
31Polydipsia (HP:0001959)2.59538831
32Abnormal drinking behavior (HP:0030082)2.59538831
33Conjugated hyperbilirubinemia (HP:0002908)2.53607259
34Hepatocellular necrosis (HP:0001404)2.53352437
35Nephronophthisis (HP:0000090)2.53129751
36Nephrogenic diabetes insipidus (HP:0009806)2.52825049
37Abnormality of DNA repair (HP:0003254)2.48270270
383-Methylglutaconic aciduria (HP:0003535)2.46819877
39Pancreatic cysts (HP:0001737)2.45781454
40Dicarboxylic aciduria (HP:0003215)2.45271169
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.45271169
42Respiratory failure (HP:0002878)2.43219362
43Absent thumb (HP:0009777)2.42002419
44Spastic paraparesis (HP:0002313)2.41900048
45Mutism (HP:0002300)2.40422583
46Abnormal number of erythroid precursors (HP:0012131)2.40257461
47Type 2 muscle fiber atrophy (HP:0003554)2.37225337
48Type II lissencephaly (HP:0007260)2.37037346
49Abnormality of T cell physiology (HP:0011840)2.35808344
50Poor suck (HP:0002033)2.25014934
51Amniotic constriction ring (HP:0009775)2.19368336
52Abnormality of placental membranes (HP:0011409)2.19368336
53Polyuria (HP:0000103)2.18539805
54Ureteral duplication (HP:0000073)2.10277806
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07462647
56Increased intramyocellular lipid droplets (HP:0012240)2.07234346
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06733922
58Muscle fiber atrophy (HP:0100295)2.06730995
59Medial flaring of the eyebrow (HP:0010747)2.05613440
60Pancreatic fibrosis (HP:0100732)2.03663233
61Leukodystrophy (HP:0002415)2.03590874
62Renal Fanconi syndrome (HP:0001994)2.01135559
63Chronic mucocutaneous candidiasis (HP:0002728)1.99774185
64Recurrent cutaneous fungal infections (HP:0011370)1.99774185
65Inability to walk (HP:0002540)1.99682316
66Agammaglobulinemia (HP:0004432)1.98485602
67Hyperglycinemia (HP:0002154)1.97589252
68Cerebral hemorrhage (HP:0001342)1.97207602
69Porencephaly (HP:0002132)1.95111993
70Cerebral edema (HP:0002181)1.95093388
71Enlarged kidneys (HP:0000105)1.92997787
72Hypomagnesemia (HP:0002917)1.90933380
73Facial diplegia (HP:0001349)1.90785633
74Hepatic necrosis (HP:0002605)1.90553196
75Optic disc pallor (HP:0000543)1.90288198
76Muscle hypertrophy of the lower extremities (HP:0008968)1.90207349
77Stenosis of the external auditory canal (HP:0000402)1.89875396
78Lethargy (HP:0001254)1.89843675
79Abolished electroretinogram (ERG) (HP:0000550)1.88633923
80Polyphagia (HP:0002591)1.88365641
81Hematochezia (HP:0002573)1.88198160
82Hypoplasia of the ulna (HP:0003022)1.87070494
83Congenital sensorineural hearing impairment (HP:0008527)1.85121036
84Lactic acidosis (HP:0003128)1.84043804
85Abnormality of the renal collecting system (HP:0004742)1.83344106
86Abnormality of the renal medulla (HP:0100957)1.83018255
87Tubulointerstitial nephritis (HP:0001970)1.82972998
88Neutropenia (HP:0001875)1.81805469
89Congenital primary aphakia (HP:0007707)1.80371928
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80162145
91Abnormal rod and cone electroretinograms (HP:0008323)1.79686546
92Abnormal urine output (HP:0012590)1.79284863
93Wide intermamillary distance (HP:0006610)1.78128814
94Abnormality of T cells (HP:0002843)1.77081245
95Exertional dyspnea (HP:0002875)1.76671253
96Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.75713412
97Gait imbalance (HP:0002141)1.75154821
98Pendular nystagmus (HP:0012043)1.75144231
99Median cleft lip (HP:0000161)1.74309196
100Chorioretinal atrophy (HP:0000533)1.72432168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.51039382
2ADRBK24.23243270
3TRIM284.16119292
4WNK43.49850309
5TXK3.09781725
6MAP2K22.91318376
7CDK192.68074189
8STK392.32601484
9NEK12.31843892
10DYRK22.11926640
11FRK2.03344746
12STK161.93103849
13NLK1.89454654
14DAPK21.79866139
15IKBKE1.75269117
16LRRK21.74695442
17WNK31.66274143
18CSNK1G31.53112400
19MAP4K11.51384361
20GRK11.44743909
21SCYL21.42518568
22ADRBK11.42068982
23CSNK1A1L1.41776354
24NUAK11.30459849
25IRAK21.29496212
26MUSK1.28938322
27CSNK1G11.26377065
28CSNK1G21.25679788
29TEC1.24974465
30MAP4K21.15088885
31EIF2AK11.09930228
32TLK11.08983238
33OXSR11.04659952
34MAPK131.01361239
35MST41.00584456
36IKBKB0.98649283
37INSRR0.97481579
38PINK10.97416333
39SYK0.96963932
40MAP2K60.91057172
41STK110.86388437
42ZAK0.85808872
43FLT30.84810201
44KIT0.84754746
45PIK3CA0.83771320
46RPS6KA50.81235877
47GRK70.79038728
48MAP3K120.73736747
49CSNK2A20.71172464
50PASK0.70458992
51BCKDK0.69593830
52CSF1R0.67626173
53CDC70.66880207
54PRKCQ0.66619197
55MAP2K10.65132273
56MARK30.62774398
57ITK0.61301083
58OBSCN0.60199934
59PAK30.59537820
60NME10.58586085
61MAP3K40.56969362
62LYN0.54951220
63PIM10.51867941
64TBK10.50945146
65PRKCE0.49581843
66TIE10.48874063
67MYLK0.47850096
68YES10.47826557
69JAK30.47544009
70PRKACA0.46994829
71EIF2AK30.46915037
72TSSK60.46382837
73STK100.46146157
74CSNK1E0.45683193
75CSNK2A10.45409223
76CSNK1A10.45204896
77PHKG20.44698336
78PHKG10.44698336
79LCK0.44538718
80PNCK0.44403122
81STK240.44138663
82ABL10.43466524
83NEK20.42525378
84MINK10.41270706
85BTK0.40431666
86MAP2K40.40128823
87DAPK30.39110549
88CCNB10.38460589
89PRKCA0.38424666
90DYRK1A0.37537180
91TAOK30.37152052
92MKNK20.36116623
93ATR0.35908732
94FES0.34775764
95PLK40.34721572
96PRKCG0.33954136
97MAP3K80.33844186
98CSNK1D0.33434478
99MELK0.32920332
100MAPK30.32281408

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.65470355
2Asthma_Homo sapiens_hsa053104.56634120
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005634.29389463
4Allograft rejection_Homo sapiens_hsa053303.68560192
5Autoimmune thyroid disease_Homo sapiens_hsa053203.53175866
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.06071113
7Graft-versus-host disease_Homo sapiens_hsa053322.82921076
8Type I diabetes mellitus_Homo sapiens_hsa049402.69510670
9Oxidative phosphorylation_Homo sapiens_hsa001902.50191249
10Primary immunodeficiency_Homo sapiens_hsa053402.47787305
11Protein export_Homo sapiens_hsa030602.44930655
12Basal transcription factors_Homo sapiens_hsa030222.13836855
13Parkinsons disease_Homo sapiens_hsa050121.90866962
14Viral myocarditis_Homo sapiens_hsa054161.85848565
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77187683
16Sulfur relay system_Homo sapiens_hsa041221.63334880
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60985920
18Proteasome_Homo sapiens_hsa030501.45822126
19Steroid biosynthesis_Homo sapiens_hsa001001.42616649
20Rheumatoid arthritis_Homo sapiens_hsa053231.39609926
21Alzheimers disease_Homo sapiens_hsa050101.38847792
22Huntingtons disease_Homo sapiens_hsa050161.35602436
23Antigen processing and presentation_Homo sapiens_hsa046121.29848374
24Hematopoietic cell lineage_Homo sapiens_hsa046401.25556049
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25491501
26Caffeine metabolism_Homo sapiens_hsa002321.23190573
27Vitamin B6 metabolism_Homo sapiens_hsa007501.21903847
28Olfactory transduction_Homo sapiens_hsa047401.20058794
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15633403
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13944994
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10122536
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08991341
33RNA polymerase_Homo sapiens_hsa030201.04463940
34Phototransduction_Homo sapiens_hsa047441.04454285
35Nicotine addiction_Homo sapiens_hsa050330.99667986
36Cardiac muscle contraction_Homo sapiens_hsa042600.98836858
37Homologous recombination_Homo sapiens_hsa034400.98359296
38Linoleic acid metabolism_Homo sapiens_hsa005910.96652220
39Mismatch repair_Homo sapiens_hsa034300.96603128
40Fanconi anemia pathway_Homo sapiens_hsa034600.94220304
41Sulfur metabolism_Homo sapiens_hsa009200.93561657
42Nucleotide excision repair_Homo sapiens_hsa034200.92967553
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92937398
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87871518
45RNA degradation_Homo sapiens_hsa030180.83229823
46Staphylococcus aureus infection_Homo sapiens_hsa051500.82351561
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80803539
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.80445662
49Pyrimidine metabolism_Homo sapiens_hsa002400.74091264
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71534149
51Collecting duct acid secretion_Homo sapiens_hsa049660.66042989
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.65177890
53Nitrogen metabolism_Homo sapiens_hsa009100.64761782
54DNA replication_Homo sapiens_hsa030300.64472384
55Systemic lupus erythematosus_Homo sapiens_hsa053220.63572388
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62782270
57RNA transport_Homo sapiens_hsa030130.61377641
58Fatty acid degradation_Homo sapiens_hsa000710.61309267
59Arachidonic acid metabolism_Homo sapiens_hsa005900.60259875
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59307999
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55504593
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.55361912
63GABAergic synapse_Homo sapiens_hsa047270.53548112
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53534560
65Regulation of autophagy_Homo sapiens_hsa041400.53417007
66Fatty acid biosynthesis_Homo sapiens_hsa000610.53389813
67Tryptophan metabolism_Homo sapiens_hsa003800.52415195
68Morphine addiction_Homo sapiens_hsa050320.51751661
69Propanoate metabolism_Homo sapiens_hsa006400.47230512
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45530430
71Serotonergic synapse_Homo sapiens_hsa047260.43923307
72Base excision repair_Homo sapiens_hsa034100.42869033
73Chemical carcinogenesis_Homo sapiens_hsa052040.41939339
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40843371
75Circadian entrainment_Homo sapiens_hsa047130.40817352
76Retinol metabolism_Homo sapiens_hsa008300.40690825
77Fat digestion and absorption_Homo sapiens_hsa049750.39128967
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39080712
79Ovarian steroidogenesis_Homo sapiens_hsa049130.38729068
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.37911890
81Herpes simplex infection_Homo sapiens_hsa051680.35656140
82Toxoplasmosis_Homo sapiens_hsa051450.35585333
83PPAR signaling pathway_Homo sapiens_hsa033200.35512437
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35133062
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34646662
86Fatty acid metabolism_Homo sapiens_hsa012120.33555112
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33043425
88Metabolic pathways_Homo sapiens_hsa011000.31804941
89T cell receptor signaling pathway_Homo sapiens_hsa046600.31580208
90Taste transduction_Homo sapiens_hsa047420.30898760
91Butanoate metabolism_Homo sapiens_hsa006500.30448967
92Starch and sucrose metabolism_Homo sapiens_hsa005000.30380922
93Glutamatergic synapse_Homo sapiens_hsa047240.30265038
94Leishmaniasis_Homo sapiens_hsa051400.28770927
95Purine metabolism_Homo sapiens_hsa002300.28309296
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.27469528
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25922119
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25068218
99Folate biosynthesis_Homo sapiens_hsa007900.24616495
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24531907

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