ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neuron cell-cell adhesion (GO:0007158)	6.77432795
2	negative regulation of cytosolic calcium ion concentration (GO:0051481)	5.35322961
3	response to pheromone (GO:0019236)	5.00341800
4	neural tube formation (GO:0001841)	4.91636696
5	atrial cardiac muscle cell action potential (GO:0086014)	4.63808280
6	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.48626141
7	synapsis (GO:0007129)	4.45519662
8	cellular ketone body metabolic process (GO:0046950)	4.42527379
9	presynaptic membrane assembly (GO:0097105)	4.16256530
10	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.09226792
11	presynaptic membrane organization (GO:0097090)	4.06829580
12	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.96147218
13	ketone body metabolic process (GO:1902224)	3.89417605
14	regulation of transmission of nerve impulse (GO:0051969)	3.83388956
15	negative regulation of cAMP-mediated signaling (GO:0043951)	3.80604517
16	L-methionine salvage (GO:0071267)	3.78195563
17	L-methionine biosynthetic process (GO:0071265)	3.78195563
18	amino acid salvage (GO:0043102)	3.78195563
19	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.74317615
20	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	3.71024728
21	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.63199236
22	behavioral response to ethanol (GO:0048149)	3.48533505
23	mitotic sister chromatid cohesion (GO:0007064)	3.46534714
24	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.43894814
25	axoneme assembly (GO:0035082)	3.39975748
26	cellular response to cholesterol (GO:0071397)	3.39164930
27	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.38426069
28	regulation of acrosome reaction (GO:0060046)	3.34858059
29	cellular response to sterol (GO:0036315)	3.34713170
30	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.31331873
31	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.30039116
32	postsynaptic membrane organization (GO:0001941)	3.29448189
33	positive regulation of cAMP-mediated signaling (GO:0043950)	3.23639123
34	photoreceptor cell maintenance (GO:0045494)	3.16779184
35	regulation of meiosis I (GO:0060631)	3.12840636
36	response to folic acid (GO:0051593)	3.08381602
37	somite development (GO:0061053)	2.98714747
38	brain morphogenesis (GO:0048854)	2.98242429
39	cellular response to ATP (GO:0071318)	2.97869158
40	meiotic chromosome segregation (GO:0045132)	2.97738280
41	cerebral cortex radially oriented cell migration (GO:0021799)	2.94269747
42	regulation of translation in response to stress (GO:0043555)	2.91263570
43	embryonic epithelial tube formation (GO:0001838)	2.90672846
44	microtubule nucleation (GO:0007020)	2.90240324
45	single strand break repair (GO:0000012)	2.90172083
46	regulation of neuron projection regeneration (GO:0070570)	2.88864480
47	regulation of axon regeneration (GO:0048679)	2.88864480
48	peptidyl-histidine modification (GO:0018202)	2.86679915
49	methionine biosynthetic process (GO:0009086)	2.86547875
50	regulation of cilium movement (GO:0003352)	2.85068917
51	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.84529448
52	resolution of meiotic recombination intermediates (GO:0000712)	2.80936800
53	nitric oxide mediated signal transduction (GO:0007263)	2.80330198
54	locomotory exploration behavior (GO:0035641)	2.77899885
55	somite rostral/caudal axis specification (GO:0032525)	2.77410950
56	C4-dicarboxylate transport (GO:0015740)	2.76071703
57	cornea development in camera-type eye (GO:0061303)	2.75977274
58	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.75782808
59	prenylation (GO:0097354)	2.70729863
60	protein prenylation (GO:0018342)	2.70729863
61	axonal fasciculation (GO:0007413)	2.70622698
62	epithelial tube formation (GO:0072175)	2.69054844
63	inositol phosphate catabolic process (GO:0071545)	2.67590812
64	kinetochore assembly (GO:0051382)	2.66429804
65	otic vesicle formation (GO:0030916)	2.64099564
66	forebrain neuron differentiation (GO:0021879)	2.62713042
67	positive regulation of macrophage activation (GO:0043032)	2.62561141
68	limb bud formation (GO:0060174)	2.61993387
69	neuroblast proliferation (GO:0007405)	2.60093633
70	ER overload response (GO:0006983)	2.59450869
71	amino-acid betaine metabolic process (GO:0006577)	2.56416395
72	centriole replication (GO:0007099)	2.55160368
73	polyol catabolic process (GO:0046174)	2.53686423
74	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	2.53389003
75	regulation of female receptivity (GO:0045924)	2.53220430
76	nonmotile primary cilium assembly (GO:0035058)	2.52346665
77	glomerulus development (GO:0032835)	2.51931431
78	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.51865220
79	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.51247662
80	primitive streak formation (GO:0090009)	2.50922506
81	head development (GO:0060322)	2.49350561
82	methionine metabolic process (GO:0006555)	2.49148857
83	microtubule anchoring (GO:0034453)	2.48999442
84	dendritic spine morphogenesis (GO:0060997)	2.48409092
85	negative regulation of appetite (GO:0032099)	2.47642401
86	negative regulation of response to food (GO:0032096)	2.47642401
87	neuronal action potential (GO:0019228)	2.46830621
88	oxidative demethylation (GO:0070989)	2.43104796
89	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.43008746
90	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.42844537
91	toxin transport (GO:1901998)	2.42381828
92	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	2.39430940
93	vascular smooth muscle contraction (GO:0014829)	2.38895370
94	regulation of glucokinase activity (GO:0033131)	2.36281091
95	regulation of hexokinase activity (GO:1903299)	2.36281091
96	histone mRNA catabolic process (GO:0071044)	2.36136806
97	startle response (GO:0001964)	2.33469919
98	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.33403441
99	neuron recognition (GO:0008038)	2.33010743
100	reflex (GO:0060004)	2.32635751

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.13985666
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.55271027
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.54090140
4	VDR_22108803_ChIP-Seq_LS180_Human	3.16503915
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.97832466
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.81628191
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.67267730
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.41189276
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.36230020
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.28343343
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.08184027
12	FUS_26573619_Chip-Seq_HEK293_Human	1.99914277
13	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.94004031
14	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.92027212
15	P300_19829295_ChIP-Seq_ESCs_Human	1.89652605
16	SMAD4_21799915_ChIP-Seq_A2780_Human	1.88150479
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88006702
18	EWS_26573619_Chip-Seq_HEK293_Human	1.83255228
19	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.78605562
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78332621
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.77812265
22	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.76690504
23	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.73335494
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.69890288
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.68884385
26	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.66104660
27	STAT3_23295773_ChIP-Seq_U87_Human	1.64852250
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63139754
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.62701901
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.62442444
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.56861438
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.55709342
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55687793
34	AR_25329375_ChIP-Seq_VCAP_Human	1.53874061
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.52923021
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.50930212
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50758258
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.50758258
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.50006630
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48282567
41	TCF4_23295773_ChIP-Seq_U87_Human	1.48162135
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.47925616
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46396315
44	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.44342357
45	IGF1R_20145208_ChIP-Seq_DFB_Human	1.42232222
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41882318
47	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40468604
48	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.39981815
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38648797
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37857716
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.36741727
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35311337
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.34928534
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.34348360
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33068322
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.32931142
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29900330
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28832675
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27971298
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.27889606
61	AR_21572438_ChIP-Seq_LNCaP_Human	1.27868770
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26724916
63	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25716833
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25131804
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25131804
66	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23988510
67	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.22248559
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21339456
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21339456
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.21123969
71	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.20141218
72	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.19893510
73	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.18437823
74	CDX2_22108803_ChIP-Seq_LS180_Human	1.15979147
75	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.13228837
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12470304
77	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.11422316
78	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.11267627
79	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.10924596
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09503011
81	MYC_18940864_ChIP-ChIP_HL60_Human	1.08840386
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08687346
83	NCOR_22424771_ChIP-Seq_293T_Human	1.08310403
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08239766
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08204669
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06558797
87	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05976468
88	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05955212
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05157651
90	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.04823235
91	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.02608595
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01908887
93	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.00303971
94	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.99167474
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98332672
96	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.97962391
97	KDM2B_26808549_Chip-Seq_REH_Human	0.97543940
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97366239
99	SOX9_26525672_Chip-Seq_HEART_Mouse	0.96492515
100	P300_18555785_Chip-Seq_ESCs_Mouse	0.95938542

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.74535427
2	MP0003880_abnormal_central_pattern	3.62658139
3	MP0004885_abnormal_endolymph	3.26195490
4	MP0001984_abnormal_olfaction	3.06211739
5	MP0000569_abnormal_digit_pigmentation	2.81570316
6	MP0002736_abnormal_nociception_after	2.62334791
7	MP0003122_maternal_imprinting	2.59958285
8	MP0001968_abnormal_touch/_nociception	2.48846422
9	MP0005367_renal/urinary_system_phenotyp	2.45760884
10	MP0000516_abnormal_urinary_system	2.45760884
11	MP0005551_abnormal_eye_electrophysiolog	2.38011944
12	MP0003283_abnormal_digestive_organ	2.37794185
13	MP0008877_abnormal_DNA_methylation	2.19659085
14	MP0003787_abnormal_imprinting	2.08545412
15	MP0002163_abnormal_gland_morphology	1.92195286
16	MP0005645_abnormal_hypothalamus_physiol	1.90721142
17	MP0005187_abnormal_penis_morphology	1.90264611
18	MP0004742_abnormal_vestibular_system	1.86140370
19	MP0002938_white_spotting	1.84522348
20	MP0002638_abnormal_pupillary_reflex	1.82587222
21	MP0008872_abnormal_physiological_respon	1.77765727
22	MP0006072_abnormal_retinal_apoptosis	1.77536088
23	MP0000427_abnormal_hair_cycle	1.73079985
24	MP0000647_abnormal_sebaceous_gland	1.66592195
25	MP0004145_abnormal_muscle_electrophysio	1.66196349
26	MP0003890_abnormal_embryonic-extraembry	1.64564794
27	MP0005646_abnormal_pituitary_gland	1.62933986
28	MP0009780_abnormal_chondrocyte_physiolo	1.60160924
29	MP0006292_abnormal_olfactory_placode	1.56056277
30	MP0000631_abnormal_neuroendocrine_gland	1.55551597
31	MP0005253_abnormal_eye_physiology	1.55344557
32	MP0008058_abnormal_DNA_repair	1.54819920
33	MP0005379_endocrine/exocrine_gland_phen	1.52803707
34	MP0006276_abnormal_autonomic_nervous	1.47178959
35	MP0003718_maternal_effect	1.46536926
36	MP0008995_early_reproductive_senescence	1.45531513
37	MP0001986_abnormal_taste_sensitivity	1.45181213
38	MP0004859_abnormal_synaptic_plasticity	1.44975396
39	MP0000538_abnormal_urinary_bladder	1.42921029
40	MP0004133_heterotaxia	1.41088749
41	MP0002557_abnormal_social/conspecific_i	1.40093993
42	MP0005248_abnormal_Harderian_gland	1.39028629
43	MP0003195_calcinosis	1.37236207
44	MP0008875_abnormal_xenobiotic_pharmacok	1.36931645
45	MP0003136_yellow_coat_color	1.36504124
46	MP0003646_muscle_fatigue	1.34166680
47	MP0002254_reproductive_system_inflammat	1.32245039
48	MP0002735_abnormal_chemical_nociception	1.30581282
49	MP0002132_abnormal_respiratory_system	1.28886203
50	MP0000778_abnormal_nervous_system	1.28760809
51	MP0005195_abnormal_posterior_eye	1.27343534
52	MP0009745_abnormal_behavioral_response	1.25343974
53	MP0005075_abnormal_melanosome_morpholog	1.24726511
54	MP0002090_abnormal_vision	1.22229574
55	MP0001486_abnormal_startle_reflex	1.21599149
56	MP0002837_dystrophic_cardiac_calcinosis	1.18945797
57	MP0000383_abnormal_hair_follicle	1.15939579
58	MP0002572_abnormal_emotion/affect_behav	1.12943158
59	MP0003121_genomic_imprinting	1.10132730
60	MP0001970_abnormal_pain_threshold	1.09839752
61	MP0002139_abnormal_hepatobiliary_system	1.08778672
62	MP0001764_abnormal_homeostasis	1.08281482
63	MP0002063_abnormal_learning/memory/cond	1.07859770
64	MP0003635_abnormal_synaptic_transmissio	1.07527072
65	MP0006035_abnormal_mitochondrial_morpho	1.05205881
66	MP0005423_abnormal_somatic_nervous	1.04396929
67	MP0001485_abnormal_pinna_reflex	1.03664849
68	MP0004215_abnormal_myocardial_fiber	1.03093389
69	MP0004043_abnormal_pH_regulation	1.03082914
70	MP0002734_abnormal_mechanical_nocicepti	1.01592378
71	MP0002272_abnormal_nervous_system	0.99610797
72	MP0008057_abnormal_DNA_replication	0.99431960
73	MP0002733_abnormal_thermal_nociception	0.94377823
74	MP0000613_abnormal_salivary_gland	0.93541997
75	MP0001293_anophthalmia	0.93001909
76	MP0005391_vision/eye_phenotype	0.90670643
77	MP0002234_abnormal_pharynx_morphology	0.90324943
78	MP0001324_abnormal_eye_pigmentation	0.88711206
79	MP0002752_abnormal_somatic_nervous	0.88046661
80	MP0001440_abnormal_grooming_behavior	0.87807936
81	MP0005408_hypopigmentation	0.85672845
82	MP0009703_decreased_birth_body	0.85249825
83	MP0002882_abnormal_neuron_morphology	0.82626062
84	MP0002067_abnormal_sensory_capabilities	0.82441085
85	MP0001501_abnormal_sleep_pattern	0.81762927
86	MP0003698_abnormal_male_reproductive	0.80726870
87	MP0004147_increased_porphyrin_level	0.79727188
88	MP0008775_abnormal_heart_ventricle	0.79600090
89	MP0000026_abnormal_inner_ear	0.78243659
90	MP0002229_neurodegeneration	0.78184881
91	MP0000049_abnormal_middle_ear	0.77724151
92	MP0002138_abnormal_hepatobiliary_system	0.76917135
93	MP0004782_abnormal_surfactant_physiolog	0.76049601
94	MP0002095_abnormal_skin_pigmentation	0.75682279
95	MP0005386_behavior/neurological_phenoty	0.75252611
96	MP0004924_abnormal_behavior	0.75252611
97	MP0005084_abnormal_gallbladder_morpholo	0.73740150
98	MP0004142_abnormal_muscle_tone	0.72058329
99	MP0002184_abnormal_innervation	0.70927633
100	MP0001963_abnormal_hearing_physiology	0.70396437

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the renal cortex (HP:0011035)	3.98169649
2	True hermaphroditism (HP:0010459)	3.90589698
3	Renal cortical cysts (HP:0000803)	3.88982700
4	Nephrogenic diabetes insipidus (HP:0009806)	3.82574041
5	Conjugated hyperbilirubinemia (HP:0002908)	3.68471457
6	Pancreatic cysts (HP:0001737)	3.65181602
7	Focal motor seizures (HP:0011153)	3.57693468
8	Colon cancer (HP:0003003)	3.53203881
9	Pancreatic fibrosis (HP:0100732)	3.48008166
10	Optic nerve hypoplasia (HP:0000609)	3.41178549
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.39847749
12	Hip dysplasia (HP:0001385)	3.37266030
13	Septo-optic dysplasia (HP:0100842)	3.27221002
14	Decreased central vision (HP:0007663)	3.25816858
15	Congenital stationary night blindness (HP:0007642)	3.23846816
16	Diastasis recti (HP:0001540)	3.21944576
17	Medial flaring of the eyebrow (HP:0010747)	3.12900846
18	Thickened calvaria (HP:0002684)	3.02500110
19	Hyperventilation (HP:0002883)	2.97229976
20	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.92072473
21	Abnormality of the renal medulla (HP:0100957)	2.88669601
22	Attenuation of retinal blood vessels (HP:0007843)	2.82193701
23	Methylmalonic aciduria (HP:0012120)	2.78866546
24	Molar tooth sign on MRI (HP:0002419)	2.75906509
25	Abnormality of midbrain morphology (HP:0002418)	2.75906509
26	Oligodactyly (hands) (HP:0001180)	2.73971337
27	Abnormality of macular pigmentation (HP:0008002)	2.71496079
28	Gait imbalance (HP:0002141)	2.69630207
29	Nephronophthisis (HP:0000090)	2.68273380
30	Congenital primary aphakia (HP:0007707)	2.64864895
31	Methylmalonic acidemia (HP:0002912)	2.59787672
32	Lissencephaly (HP:0001339)	2.59194242
33	3-Methylglutaconic aciduria (HP:0003535)	2.55947726
34	Hypoglycemic coma (HP:0001325)	2.51200678
35	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.47931160
36	Hemiparesis (HP:0001269)	2.47491138
37	Pendular nystagmus (HP:0012043)	2.45733394
38	Hypoplastic iliac wings (HP:0002866)	2.38659632
39	Focal seizures (HP:0007359)	2.38314007
40	Cystic liver disease (HP:0006706)	2.37113944
41	Abnormality of methionine metabolism (HP:0010901)	2.34345178
42	Genital tract atresia (HP:0001827)	2.29894343
43	Occipital encephalocele (HP:0002085)	2.27071760
44	Anophthalmia (HP:0000528)	2.25609316
45	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.23114082
46	Small hand (HP:0200055)	2.21524794
47	Vaginal atresia (HP:0000148)	2.19530651
48	Polyphagia (HP:0002591)	2.18117274
49	Abnormality of alanine metabolism (HP:0010916)	2.18015646
50	Hyperalaninemia (HP:0003348)	2.18015646
51	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.18015646
52	Bony spicule pigmentary retinopathy (HP:0007737)	2.12083775
53	Chronic hepatic failure (HP:0100626)	2.12012373
54	Fibular hypoplasia (HP:0003038)	2.07209991
55	Furrowed tongue (HP:0000221)	2.06289715
56	Abnormality of vitamin B metabolism (HP:0004340)	2.03536613
57	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.99236160
58	Pachygyria (HP:0001302)	1.97593746
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.97464936
60	Tubulointerstitial abnormality (HP:0001969)	1.97150884
61	Rectal prolapse (HP:0002035)	1.97070881
62	Broad alveolar ridges (HP:0000187)	1.93446606
63	Type II lissencephaly (HP:0007260)	1.93020235
64	Absent eyebrow (HP:0002223)	1.91814134
65	Absent septum pellucidum (HP:0001331)	1.91184957
66	Broad foot (HP:0001769)	1.90062080
67	Absent speech (HP:0001344)	1.89445229
68	Arthropathy (HP:0003040)	1.87276403
69	Stenosis of the external auditory canal (HP:0000402)	1.87262598
70	Poor coordination (HP:0002370)	1.86388538
71	Widely spaced teeth (HP:0000687)	1.85095559
72	Tubulointerstitial nephritis (HP:0001970)	1.84957039
73	Megalencephaly (HP:0001355)	1.84665491
74	Gaze-evoked nystagmus (HP:0000640)	1.83910186
75	Abnormality of the septum pellucidum (HP:0007375)	1.82147104
76	Constricted visual fields (HP:0001133)	1.82020352
77	Tubulointerstitial fibrosis (HP:0005576)	1.79939409
78	11 pairs of ribs (HP:0000878)	1.79635976
79	Cerebellar dysplasia (HP:0007033)	1.79081166
80	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.78840193
81	Short foot (HP:0001773)	1.78634154
82	Volvulus (HP:0002580)	1.77419848
83	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.77124121
84	Vitreoretinal degeneration (HP:0000655)	1.77018951
85	Postaxial hand polydactyly (HP:0001162)	1.76445076
86	Hypokalemic alkalosis (HP:0001949)	1.76032327
87	Astigmatism (HP:0000483)	1.75347192
88	Abnormality of the wing of the ilium (HP:0011867)	1.74821466
89	Increased corneal curvature (HP:0100692)	1.73280054
90	Keratoconus (HP:0000563)	1.73280054
91	Chorioretinal atrophy (HP:0000533)	1.73064089
92	Abnormality of the lumbar spine (HP:0100712)	1.72554075
93	Congenital sensorineural hearing impairment (HP:0008527)	1.70197250
94	Male pseudohermaphroditism (HP:0000037)	1.70036528
95	Beaking of vertebral bodies (HP:0004568)	1.70008165
96	Metabolic alkalosis (HP:0200114)	1.69016862
97	Adenoma sebaceum (HP:0009720)	1.66859024
98	Angiofibromas (HP:0010615)	1.66859024
99	Febrile seizures (HP:0002373)	1.66406956
100	Growth hormone deficiency (HP:0000824)	1.66329493

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	5.69509707
2	LATS1	5.02293304
3	CASK	4.88376855
4	FRK	3.61533925
5	ADRBK2	2.97202863
6	EPHA4	2.93736604
7	PNCK	2.49599605
8	MARK1	2.40185375
9	MAP3K4	2.32384487
10	STK3	2.06966761
11	PINK1	2.04536415
12	TNIK	1.92608575
13	BMPR1B	1.85206029
14	BUB1	1.76161617
15	CAMKK2	1.69188136
16	MAP2K7	1.69096812
17	PDK2	1.66664489
18	STK4	1.55157274
19	WNK3	1.54459667
20	PAK3	1.53680173
21	GRK1	1.51268515
22	INSRR	1.46249191
23	CSNK1G1	1.43725891
24	MAP2K6	1.39760955
25	CAMK1G	1.38533806
26	NTRK3	1.33321421
27	YES1	1.33149617
28	BCKDK	1.32604700
29	NLK	1.25254434
30	FGFR3	1.20437883
31	AKT3	1.17773135
32	CDK3	1.12729021
33	MAP4K2	1.05985170
34	ACVR1B	0.95848236
35	CDK19	0.95323538
36	DMPK	0.94931110
37	ERBB3	0.93693481
38	WNK4	0.91293392
39	WEE1	0.89686826
40	MAPK13	0.88581446
41	NTRK2	0.86739332
42	DYRK2	0.85790204
43	BRSK2	0.82799416
44	MKNK2	0.78506583
45	FGFR2	0.75606090
46	CSNK1G3	0.73600005
47	MAP2K4	0.71036645
48	CAMK1D	0.70499005
49	PRKCG	0.65683820
50	PHKG1	0.65441796
51	PHKG2	0.65441796
52	DAPK2	0.64958525
53	PRKCE	0.64170863
54	CAMK1	0.62768738
55	CSNK1G2	0.58151647
56	BCR	0.57015754
57	PLK2	0.56223366
58	PIK3CG	0.54409258
59	PRKCH	0.51275014
60	SIK2	0.48683988
61	SGK2	0.48394632
62	CSNK1A1L	0.47611277
63	ROCK1	0.46934163
64	BMPR2	0.46552025
65	GSK3A	0.46412246
66	ADRBK1	0.46005450
67	TGFBR1	0.45580496
68	FGFR1	0.43943054
69	PRKD3	0.43492366
70	ATM	0.43372432
71	SIK3	0.42482827
72	FER	0.41099362
73	CAMK2A	0.39125358
74	CSNK1E	0.38427218
75	PLK4	0.38280158
76	CCNB1	0.35763742
77	MUSK	0.33603352
78	ERBB4	0.31643604
79	PRKG1	0.31078304
80	PKN1	0.30769294
81	ROCK2	0.30490449
82	PRKACB	0.30065680
83	SGK223	0.29390332
84	SGK494	0.29390332
85	STK39	0.28913469
86	PLK3	0.28151017
87	PRKAA1	0.26258945
88	VRK1	0.26213680
89	CSNK1A1	0.26078710
90	ILK	0.25567318
91	PRKD2	0.25417782
92	MKNK1	0.25084318
93	PTK2B	0.24383468
94	TAOK2	0.23776710
95	MET	0.23305510
96	KIT	0.23292634
97	PLK1	0.22676643
98	TLK1	0.22074006
99	OXSR1	0.21601884
100	PRKCQ	0.21306287

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.38464133
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.46701056
3	Butanoate metabolism_Homo sapiens_hsa00650	2.98916114
4	Phototransduction_Homo sapiens_hsa04744	2.74657130
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.65630746
6	Taste transduction_Homo sapiens_hsa04742	2.47093091
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.11563447
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.04819643
9	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.00035143
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.88853793
11	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.85152072
12	One carbon pool by folate_Homo sapiens_hsa00670	1.75167264
13	Protein export_Homo sapiens_hsa03060	1.71605766
14	Nicotine addiction_Homo sapiens_hsa05033	1.71034326
15	Steroid biosynthesis_Homo sapiens_hsa00100	1.66544204
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.64924481
17	ABC transporters_Homo sapiens_hsa02010	1.63087365
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.61208457
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.58153475
20	Caffeine metabolism_Homo sapiens_hsa00232	1.55279114
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48942595
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.47484823
23	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.45001915
24	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.36230665
25	Propanoate metabolism_Homo sapiens_hsa00640	1.26850763
26	Circadian entrainment_Homo sapiens_hsa04713	1.22734889
27	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.21494825
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.21306801
29	Olfactory transduction_Homo sapiens_hsa04740	1.18659922
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.18399810
31	Basal transcription factors_Homo sapiens_hsa03022	1.15404676
32	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.13773204
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12878908
34	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.12428681
35	Collecting duct acid secretion_Homo sapiens_hsa04966	1.10430139
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.07825087
37	Insulin secretion_Homo sapiens_hsa04911	1.07296588
38	Basal cell carcinoma_Homo sapiens_hsa05217	1.03381964
39	Circadian rhythm_Homo sapiens_hsa04710	1.02988108
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97973658
41	Retinol metabolism_Homo sapiens_hsa00830	0.95559161
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92669417
43	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.90167478
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89870522
45	Dopaminergic synapse_Homo sapiens_hsa04728	0.87738598
46	Cocaine addiction_Homo sapiens_hsa05030	0.86513666
47	Peroxisome_Homo sapiens_hsa04146	0.86466711
48	Salivary secretion_Homo sapiens_hsa04970	0.85106646
49	Homologous recombination_Homo sapiens_hsa03440	0.84441766
50	Morphine addiction_Homo sapiens_hsa05032	0.84044901
51	cAMP signaling pathway_Homo sapiens_hsa04024	0.80171233
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.78703822
53	Long-term depression_Homo sapiens_hsa04730	0.78581917
54	Regulation of autophagy_Homo sapiens_hsa04140	0.77605285
55	Sphingolipid metabolism_Homo sapiens_hsa00600	0.77278611
56	Oxidative phosphorylation_Homo sapiens_hsa00190	0.75433347
57	Amphetamine addiction_Homo sapiens_hsa05031	0.74710194
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72493981
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.71929003
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.68757642
61	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.68154306
62	Fatty acid elongation_Homo sapiens_hsa00062	0.67992070
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66792643
64	Folate biosynthesis_Homo sapiens_hsa00790	0.66090006
65	Hippo signaling pathway_Homo sapiens_hsa04390	0.66002400
66	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.60445226
67	Calcium signaling pathway_Homo sapiens_hsa04020	0.58872867
68	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.58544996
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.57228733
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56251209
71	RNA degradation_Homo sapiens_hsa03018	0.55129600
72	Axon guidance_Homo sapiens_hsa04360	0.54378612
73	Purine metabolism_Homo sapiens_hsa00230	0.53477748
74	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.51750308
75	GABAergic synapse_Homo sapiens_hsa04727	0.51713192
76	Serotonergic synapse_Homo sapiens_hsa04726	0.50399836
77	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.48913771
78	Fatty acid degradation_Homo sapiens_hsa00071	0.48306270
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48167949
80	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46687745
81	Wnt signaling pathway_Homo sapiens_hsa04310	0.45799230
82	RNA transport_Homo sapiens_hsa03013	0.45219503
83	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44988145
84	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.43287770
85	Oocyte meiosis_Homo sapiens_hsa04114	0.42328606
86	Metabolic pathways_Homo sapiens_hsa01100	0.41454363
87	Non-homologous end-joining_Homo sapiens_hsa03450	0.40762646
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40104120
89	FoxO signaling pathway_Homo sapiens_hsa04068	0.40015650
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39596769
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39549283
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38052023
93	Type II diabetes mellitus_Homo sapiens_hsa04930	0.37054933
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35607835
95	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.35586556
96	Base excision repair_Homo sapiens_hsa03410	0.33344646
97	Renin secretion_Homo sapiens_hsa04924	0.32579418
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.32187567
99	Cardiac muscle contraction_Homo sapiens_hsa04260	0.30565341
100	Lysine degradation_Homo sapiens_hsa00310	0.29745202

RPL21P32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »