RPL21P33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.22237647
2cytidine deamination (GO:0009972)5.59703114
3cytidine metabolic process (GO:0046087)5.59703114
4cytidine catabolic process (GO:0006216)5.59703114
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.11675579
6pyrimidine ribonucleoside catabolic process (GO:0046133)4.86547402
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.79723488
8ATP synthesis coupled proton transport (GO:0015986)4.55530503
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.55530503
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.29585335
11Arp2/3 complex-mediated actin nucleation (GO:0034314)3.96097419
12respiratory electron transport chain (GO:0022904)3.91477525
13electron transport chain (GO:0022900)3.87484392
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.82698434
15actin nucleation (GO:0045010)3.77990283
16platelet dense granule organization (GO:0060155)3.70111816
17ribosomal small subunit assembly (GO:0000028)3.66453954
18positive thymic T cell selection (GO:0045059)3.57450007
19regulation of B cell receptor signaling pathway (GO:0050855)3.57430333
20positive T cell selection (GO:0043368)3.51369302
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.50984295
22positive regulation of interleukin-8 secretion (GO:2000484)3.38404958
23regulation of interleukin-8 secretion (GO:2000482)3.37607977
24positive regulation of T cell mediated cytotoxicity (GO:0001916)3.36457654
25negative T cell selection (GO:0043383)3.34077294
26regulation of T cell receptor signaling pathway (GO:0050856)3.33391802
27negative regulation of T cell apoptotic process (GO:0070233)3.31462704
28positive regulation of calcium-mediated signaling (GO:0050850)3.30821941
29protein neddylation (GO:0045116)3.29640555
30regulation of regulatory T cell differentiation (GO:0045589)3.28446810
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.26334079
32cellular response to interleukin-15 (GO:0071350)3.23768632
33sequestering of actin monomers (GO:0042989)3.23293801
34positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.22363240
35tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19958290
36RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19958290
37regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.12131208
38mast cell activation (GO:0045576)3.09689834
39T cell receptor signaling pathway (GO:0050852)3.08281908
40regulation of T cell mediated cytotoxicity (GO:0001914)3.08038592
41regulation of activation of Janus kinase activity (GO:0010533)3.08026076
42T cell migration (GO:0072678)3.06250435
43positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.03382165
44positive regulation of natural killer cell mediated immunity (GO:0002717)3.01025602
45GPI anchor metabolic process (GO:0006505)3.01016099
46GPI anchor biosynthetic process (GO:0006506)3.00451394
47protein complex biogenesis (GO:0070271)3.00087332
48response to pheromone (GO:0019236)2.99812826
49T cell costimulation (GO:0031295)2.97734011
50negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.97491282
51regulation of leukocyte mediated cytotoxicity (GO:0001910)2.95203281
52lymphocyte costimulation (GO:0031294)2.94518983
53positive regulation of alpha-beta T cell proliferation (GO:0046641)2.91414550
54hydrogen ion transmembrane transport (GO:1902600)2.89572217
55immunoglobulin mediated immune response (GO:0016064)2.87847135
56negative regulation of mast cell activation (GO:0033004)2.82901579
57mannosylation (GO:0097502)2.82174297
58proton transport (GO:0015992)2.78177724
59positive regulation of cell killing (GO:0031343)2.77428933
60regulation of alpha-beta T cell proliferation (GO:0046640)2.76068838
61hydrogen transport (GO:0006818)2.73730097
62regulation of T cell tolerance induction (GO:0002664)2.73435952
63pyrimidine nucleoside catabolic process (GO:0046135)2.70807409
64negative thymic T cell selection (GO:0045060)2.70772802
65regulation of cellular amino acid metabolic process (GO:0006521)2.68801708
66antigen receptor-mediated signaling pathway (GO:0050851)2.68686853
67proteasome assembly (GO:0043248)2.68546389
68positive regulation of defense response to virus by host (GO:0002230)2.66080823
69response to interferon-beta (GO:0035456)2.65954630
70regulation of natural killer cell mediated immunity (GO:0002715)2.64532897
71regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.64532897
72ATP biosynthetic process (GO:0006754)2.62817620
73positive regulation of tolerance induction (GO:0002645)2.61795784
74cytolysis (GO:0019835)2.61527243
75regulation of cell killing (GO:0031341)2.61353777
76regulation of calcium-mediated signaling (GO:0050848)2.60055710
77respiratory chain complex IV assembly (GO:0008535)2.58081821
78cytochrome complex assembly (GO:0017004)2.56767369
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.56535530
80mitochondrial respiratory chain complex assembly (GO:0033108)2.55085216
81positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.54925156
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.52734430
83positive regulation of gamma-delta T cell activation (GO:0046645)2.51935211
84NADH dehydrogenase complex assembly (GO:0010257)2.50144377
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50144377
86mitochondrial respiratory chain complex I assembly (GO:0032981)2.50144377
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.49388206
88negative regulation of T cell receptor signaling pathway (GO:0050860)2.49180410
89negative regulation by host of viral transcription (GO:0043922)2.48848870
90thymic T cell selection (GO:0045061)2.48045368
91negative regulation of heart rate (GO:0010459)2.47843015
92negative regulation of lymphocyte apoptotic process (GO:0070229)2.46693745
93antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.46566100
94antigen processing and presentation via MHC class Ib (GO:0002475)2.46307747
95water-soluble vitamin biosynthetic process (GO:0042364)2.46086911
96purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.45578117
97negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.45318116
98positive regulation of B cell differentiation (GO:0045579)2.44699295
99purine nucleoside triphosphate biosynthetic process (GO:0009145)2.44505534
100protein targeting to ER (GO:0045047)2.44064770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.94217003
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.33727318
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.29072640
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.07324919
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92424980
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.75327905
7VDR_22108803_ChIP-Seq_LS180_Human2.73509131
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.72104382
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47678163
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.46874877
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.40560019
12IGF1R_20145208_ChIP-Seq_DFB_Human2.39088036
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.36436253
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21904007
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.15940171
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15628691
17ZNF274_21170338_ChIP-Seq_K562_Hela2.15473200
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09203417
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06468348
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02520804
21VDR_23849224_ChIP-Seq_CD4+_Human1.99403644
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89075906
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88546279
24MYB_26560356_Chip-Seq_TH2_Human1.84589041
25GATA3_26560356_Chip-Seq_TH2_Human1.73810368
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65047344
27EZH2_22144423_ChIP-Seq_EOC_Human1.63247150
28TP53_22573176_ChIP-Seq_HFKS_Human1.56265786
29RUNX_20019798_ChIP-Seq_JUKART_Human1.55857300
30AR_20517297_ChIP-Seq_VCAP_Human1.54929182
31GATA3_27048872_Chip-Seq_THYMUS_Human1.52035268
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51415930
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50416649
34FOXA1_27270436_Chip-Seq_PROSTATE_Human1.50277769
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.50277769
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48742066
37TAF15_26573619_Chip-Seq_HEK293_Human1.46479097
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44859500
39ELK1_19687146_ChIP-ChIP_HELA_Human1.42225866
40ER_23166858_ChIP-Seq_MCF-7_Human1.39926539
41FOXP3_21729870_ChIP-Seq_TREG_Human1.37890598
42NANOG_19829295_ChIP-Seq_ESCs_Human1.37055333
43SOX2_19829295_ChIP-Seq_ESCs_Human1.37055333
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.36450047
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36432414
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35352918
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.35287672
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34739389
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.34031492
50MYC_18940864_ChIP-ChIP_HL60_Human1.33730506
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32623288
52EWS_26573619_Chip-Seq_HEK293_Human1.31435507
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30101401
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29857615
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.29748795
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29221095
57P300_19829295_ChIP-Seq_ESCs_Human1.29068252
58FUS_26573619_Chip-Seq_HEK293_Human1.27556709
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.22479056
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21576757
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21429077
62BCAT_22108803_ChIP-Seq_LS180_Human1.19821257
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.19678253
64PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.19372640
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18944658
66CBP_20019798_ChIP-Seq_JUKART_Human1.18944658
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17914362
68NCOR_22424771_ChIP-Seq_293T_Human1.16760279
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.16532430
70NANOG_20526341_ChIP-Seq_ESCs_Human1.16164326
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16041103
72ERG_20517297_ChIP-Seq_VCAP_Human1.15968965
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15673139
74TAF2_19829295_ChIP-Seq_ESCs_Human1.15409270
75HTT_18923047_ChIP-ChIP_STHdh_Human1.14548160
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13205559
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13194673
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13001325
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12489975
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10362288
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09849136
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.09150173
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07888713
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07268150
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06645375
86MYC_19829295_ChIP-Seq_ESCs_Human1.05691828
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05538751
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.05475796
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02623686
90GBX2_23144817_ChIP-Seq_PC3_Human1.02312782
91STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99940033
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98402673
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.98361839
94RBPJ_21746931_ChIP-Seq_IB4_Human0.98268923
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97884699
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96844197
97MYB_26560356_Chip-Seq_TH1_Human0.95520130
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93449615
99TCF4_22108803_ChIP-Seq_LS180_Human0.91479094
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91454027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.12903615
2MP0001835_abnormal_antigen_presentation3.54144484
3MP0009785_altered_susceptibility_to2.82088818
4MP0009379_abnormal_foot_pigmentation2.59301530
5MP0006072_abnormal_retinal_apoptosis2.55993348
6MP0005000_abnormal_immune_tolerance2.26757894
7MP0002166_altered_tumor_susceptibility2.24515024
8MP0005645_abnormal_hypothalamus_physiol2.18305948
9MP0001800_abnormal_humoral_immune2.15109417
10MP0003763_abnormal_thymus_physiology2.12171390
11MP0002148_abnormal_hypersensitivity_rea2.06174230
12MP0005075_abnormal_melanosome_morpholog1.99152187
13MP0005646_abnormal_pituitary_gland1.94749081
14MP0009333_abnormal_splenocyte_physiolog1.91019610
15MP0002723_abnormal_immune_serum1.88820932
16MP0002837_dystrophic_cardiac_calcinosis1.88697908
17MP0003195_calcinosis1.85770601
18MP0002102_abnormal_ear_morphology1.85576972
19MP0000372_irregular_coat_pigmentation1.83885664
20MP0000685_abnormal_immune_system1.77429223
21MP0003866_abnormal_defecation1.77036842
22MP0002420_abnormal_adaptive_immunity1.75792566
23MP0005025_abnormal_response_to1.75600343
24MP0002876_abnormal_thyroid_physiology1.74473059
25MP0001819_abnormal_immune_cell1.73478033
26MP0008877_abnormal_DNA_methylation1.72600069
27MP0008872_abnormal_physiological_respon1.71911709
28MP0002006_tumorigenesis1.67669521
29MP0002452_abnormal_antigen_presenting1.65138869
30MP0003011_delayed_dark_adaptation1.64770878
31MP0002163_abnormal_gland_morphology1.64400461
32MP0003724_increased_susceptibility_to1.62575359
33MP0003646_muscle_fatigue1.60217590
34MP0005387_immune_system_phenotype1.59556747
35MP0001790_abnormal_immune_system1.59556747
36MP0006082_CNS_inflammation1.58237350
37MP0005551_abnormal_eye_electrophysiolog1.57148975
38MP0005253_abnormal_eye_physiology1.54768431
39MP0004147_increased_porphyrin_level1.46342280
40MP0001919_abnormal_reproductive_system1.36701289
41MP0005379_endocrine/exocrine_gland_phen1.34969521
42MP0001905_abnormal_dopamine_level1.30501986
43MP0000716_abnormal_immune_system1.30471117
44MP0009764_decreased_sensitivity_to1.29697271
45MP0010155_abnormal_intestine_physiology1.29659664
46MP0004145_abnormal_muscle_electrophysio1.29581537
47MP0008875_abnormal_xenobiotic_pharmacok1.26675270
48MP0001845_abnormal_inflammatory_respons1.25891958
49MP0005389_reproductive_system_phenotype1.25034488
50MP0003787_abnormal_imprinting1.22389167
51MP0001986_abnormal_taste_sensitivity1.22205690
52MP0002398_abnormal_bone_marrow1.21082461
53MP0002138_abnormal_hepatobiliary_system1.17456763
54MP0008995_early_reproductive_senescence1.16952674
55MP0001968_abnormal_touch/_nociception1.15170966
56MP0001873_stomach_inflammation1.14881984
57MP0005084_abnormal_gallbladder_morpholo1.14631149
58MP0006292_abnormal_olfactory_placode1.14448519
59MP0002638_abnormal_pupillary_reflex1.12418700
60MP0003880_abnormal_central_pattern1.11574043
61MP0002693_abnormal_pancreas_physiology1.10028765
62MP0002405_respiratory_system_inflammati1.08763991
63MP0002419_abnormal_innate_immunity1.07956236
64MP0004885_abnormal_endolymph1.07870289
65MP0000689_abnormal_spleen_morphology1.07480418
66MP0003806_abnormal_nucleotide_metabolis1.07460753
67MP0002933_joint_inflammation1.06112583
68MP0001765_abnormal_ion_homeostasis1.05817956
69MP0003878_abnormal_ear_physiology1.04339652
70MP0005377_hearing/vestibular/ear_phenot1.04339652
71MP0010386_abnormal_urinary_bladder1.03046180
72MP0008469_abnormal_protein_level1.02062177
73MP0005636_abnormal_mineral_homeostasis1.01516973
74MP0004142_abnormal_muscle_tone1.01001069
75MP0001501_abnormal_sleep_pattern0.98503606
76MP0003786_premature_aging0.95999273
77MP0005410_abnormal_fertilization0.94577127
78MP0002736_abnormal_nociception_after0.94412755
79MP0001764_abnormal_homeostasis0.94343308
80MP0006036_abnormal_mitochondrial_physio0.93663784
81MP0002722_abnormal_immune_system0.92874634
82MP0006276_abnormal_autonomic_nervous0.92415044
83MP0002095_abnormal_skin_pigmentation0.91606335
84MP0002429_abnormal_blood_cell0.91194488
85MP0005174_abnormal_tail_pigmentation0.90572013
86MP0003252_abnormal_bile_duct0.90267489
87MP0003436_decreased_susceptibility_to0.87939289
88MP0002272_abnormal_nervous_system0.85760598
89MP0002277_abnormal_respiratory_mucosa0.85574116
90MP0000703_abnormal_thymus_morphology0.85132767
91MP0009745_abnormal_behavioral_response0.82210507
92MP0005464_abnormal_platelet_physiology0.78538221
93MP0003045_fibrosis0.75980108
94MP0009643_abnormal_urine_homeostasis0.75106178
95MP0001970_abnormal_pain_threshold0.74716901
96MP0009046_muscle_twitch0.73167713
97MP0005085_abnormal_gallbladder_physiolo0.73052280
98MP0000465_gastrointestinal_hemorrhage0.72838372
99MP0002160_abnormal_reproductive_system0.71991660
100MP0001485_abnormal_pinna_reflex0.71155555

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.23688988
2Severe combined immunodeficiency (HP:0004430)4.07891671
33-Methylglutaconic aciduria (HP:0003535)3.99735525
4Mitochondrial inheritance (HP:0001427)3.99035648
5Hypoproteinemia (HP:0003075)3.92786064
6Acute necrotizing encephalopathy (HP:0006965)3.92027694
7Aplastic anemia (HP:0001915)3.82090202
8Congenital stationary night blindness (HP:0007642)3.71025874
9Thyroiditis (HP:0100646)3.65236382
10T lymphocytopenia (HP:0005403)3.64842150
11Abnormal mitochondria in muscle tissue (HP:0008316)3.53370562
12Abnormality of T cell number (HP:0011839)3.53296230
13Hepatocellular necrosis (HP:0001404)3.52623618
14Abnormality of B cell number (HP:0010975)3.52310598
15Progressive macrocephaly (HP:0004481)3.47586707
16Elevated erythrocyte sedimentation rate (HP:0003565)3.44213656
17Increased CSF lactate (HP:0002490)3.37337280
18B lymphocytopenia (HP:0010976)3.25316798
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.24815180
20Hepatic necrosis (HP:0002605)3.16831860
21Acute encephalopathy (HP:0006846)3.08471562
22Combined immunodeficiency (HP:0005387)3.06201542
23Increased hepatocellular lipid droplets (HP:0006565)2.96380936
24Abnormal rod and cone electroretinograms (HP:0008323)2.92184029
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87522476
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87522476
27Pancreatic cysts (HP:0001737)2.85867713
28Stomatitis (HP:0010280)2.84253595
29Increased intramyocellular lipid droplets (HP:0012240)2.81364372
30Abnormality of eosinophils (HP:0001879)2.77040158
31Abnormality of T cells (HP:0002843)2.74771964
32Lipid accumulation in hepatocytes (HP:0006561)2.70020951
33Abolished electroretinogram (ERG) (HP:0000550)2.65559598
34Congenital, generalized hypertrichosis (HP:0004540)2.61863447
35Attenuation of retinal blood vessels (HP:0007843)2.59346923
36Abnormality of the prostate (HP:0008775)2.57171810
37Autoimmune hemolytic anemia (HP:0001890)2.54637680
38Cerebral edema (HP:0002181)2.53879450
39Methylmalonic acidemia (HP:0002912)2.52001057
40Increased IgM level (HP:0003496)2.48237529
41Renal Fanconi syndrome (HP:0001994)2.47804288
42Hypothermia (HP:0002045)2.45179862
43Optic disc pallor (HP:0000543)2.43987130
44Chronic diarrhea (HP:0002028)2.40908379
45Abnormality of midbrain morphology (HP:0002418)2.40709323
46Molar tooth sign on MRI (HP:0002419)2.40709323
47Decreased central vision (HP:0007663)2.38143650
48Increased muscle lipid content (HP:0009058)2.31844339
49Exertional dyspnea (HP:0002875)2.27815237
50Pancreatic fibrosis (HP:0100732)2.27248707
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.26753551
52True hermaphroditism (HP:0010459)2.26615188
53Constricted visual fields (HP:0001133)2.25405311
54Eosinophilia (HP:0001880)2.24161319
55Abnormal albumin level (HP:0012116)2.22693190
56Hypoalbuminemia (HP:0003073)2.22693190
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20236903
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19697297
59Ketoacidosis (HP:0001993)2.13592165
60Lactic acidosis (HP:0003128)2.12981467
61Recurrent bronchitis (HP:0002837)2.09464719
62Ketosis (HP:0001946)2.07146417
63Panhypogammaglobulinemia (HP:0003139)2.06925663
64Renal cortical cysts (HP:0000803)2.05502778
65Increased serum lactate (HP:0002151)2.04416312
66Abnormality of the renal cortex (HP:0011035)2.01289120
67Respiratory failure (HP:0002878)1.98084581
68Type I transferrin isoform profile (HP:0003642)1.95752568
69Medial flaring of the eyebrow (HP:0010747)1.94331934
70Methylmalonic aciduria (HP:0012120)1.94102663
71Leukocytosis (HP:0001974)1.94065643
72Lethargy (HP:0001254)1.87378678
73Cerebral palsy (HP:0100021)1.83741106
74Nephronophthisis (HP:0000090)1.82343085
75Pancytopenia (HP:0001876)1.81720454
76Type 2 muscle fiber atrophy (HP:0003554)1.81586254
77Meningitis (HP:0001287)1.80851044
78Encephalitis (HP:0002383)1.80621965
79Abnormality of T cell physiology (HP:0011840)1.80587263
80Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80084121
81Dicarboxylic aciduria (HP:0003215)1.80084121
82Bronchitis (HP:0012387)1.77437995
83Abnormal glycosylation (HP:0012345)1.76862414
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76862414
85Abnormal protein N-linked glycosylation (HP:0012347)1.76862414
86Abnormal protein glycosylation (HP:0012346)1.76862414
87Abnormality of urine glucose concentration (HP:0011016)1.74834687
88Glycosuria (HP:0003076)1.74834687
89Aplasia/hypoplasia of the uterus (HP:0008684)1.73259208
90Abnormal drinking behavior (HP:0030082)1.73253268
91Polydipsia (HP:0001959)1.73253268
92Vasculitis (HP:0002633)1.71840759
93Agammaglobulinemia (HP:0004432)1.71701955
94Leukodystrophy (HP:0002415)1.70125241
95Stomach cancer (HP:0012126)1.69907151
96Pulmonary infiltrates (HP:0002113)1.67940451
97Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.67616688
98IgM deficiency (HP:0002850)1.67307934
99Chronic obstructive pulmonary disease (HP:0006510)1.67072577
100Obstructive lung disease (HP:0006536)1.67072577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.44148873
2KDR3.86958525
3TESK23.47533240
4MAP4K23.00377413
5TAOK32.90612017
6MAP3K122.76558837
7FRK2.62217283
8GRK12.51681134
9BCKDK2.36559963
10ADRBK22.27802378
11CDK192.25690047
12ZAK2.19110089
13TLK12.19075214
14SCYL22.03664069
15MAP4K11.97462778
16BMPR21.96865186
17ITK1.93374405
18FES1.70268456
19PINK11.66157417
20GRK61.60313581
21NUAK11.57438209
22TEC1.54489776
23MYLK1.53472978
24TRPM71.47292330
25VRK21.42356922
26PASK1.41491563
27SYK1.40950903
28LIMK11.38705784
29WNK41.31781230
30ERBB31.23057764
31MUSK1.19893011
32VRK11.16065672
33KIT1.12852554
34IKBKB1.11302032
35INSRR1.09278967
36DAPK11.04872587
37BTK1.03521629
38LCK1.01914184
39CSF1R1.01423733
40DAPK21.01150982
41LYN1.00540331
42TNK20.97571368
43TESK10.96012568
44IKBKE0.94939780
45OXSR10.93581993
46STK160.91095764
47MST40.89481883
48GRK70.89413226
49WNK30.89374149
50PRKCQ0.87436447
51TIE10.82775909
52ZAP700.81295419
53EIF2AK30.77954056
54OBSCN0.77045046
55PIK3CG0.76666753
56RPS6KA50.74692981
57MAP2K60.73191171
58ILK0.66260328
59JAK30.65932972
60CAMKK20.65406427
61CSK0.65093821
62CSNK1G30.62543082
63DAPK30.61471561
64IGF1R0.60379570
65TRIM280.57811737
66BMPR1B0.57805664
67PHKG10.57526946
68PHKG20.57526946
69STK390.55816717
70ROCK10.55525308
71NME10.53405016
72ADRBK10.50151272
73MATK0.50092864
74TBK10.49721026
75MAPKAPK30.49460894
76CSNK1G10.49280517
77PIM10.49231943
78RPS6KA40.48257338
79PRKCE0.47750847
80HCK0.46451972
81PRKACA0.44838279
82PRKCA0.43560706
83ABL10.42994841
84CSNK1G20.42947822
85MAPK130.40404553
86FLT30.39984392
87PIK3CA0.36615958
88MAP2K70.35521957
89FYN0.35110593
90CAMK2A0.33157090
91RIPK40.32967822
92CAMKK10.32692857
93GRK50.31547951
94MAP3K110.30067322
95CSNK2A10.29817505
96CSNK1A1L0.29414395
97EGFR0.28185497
98INSR0.26897473
99CSNK1A10.26612432
100PRKG10.26568418

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.81500152
2Oxidative phosphorylation_Homo sapiens_hsa001903.61252673
3Allograft rejection_Homo sapiens_hsa053303.42923555
4Graft-versus-host disease_Homo sapiens_hsa053323.38763223
5Asthma_Homo sapiens_hsa053103.37759450
6Autoimmune thyroid disease_Homo sapiens_hsa053203.36124151
7Proteasome_Homo sapiens_hsa030503.16769914
8Type I diabetes mellitus_Homo sapiens_hsa049403.16624543
9Parkinsons disease_Homo sapiens_hsa050122.83354068
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.78913877
11Ribosome_Homo sapiens_hsa030102.45071253
12Antigen processing and presentation_Homo sapiens_hsa046122.43307146
13Protein export_Homo sapiens_hsa030602.38779046
14Alzheimers disease_Homo sapiens_hsa050101.95689257
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86046605
16Rheumatoid arthritis_Homo sapiens_hsa053231.82389858
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79821469
18Hematopoietic cell lineage_Homo sapiens_hsa046401.78439528
19Phototransduction_Homo sapiens_hsa047441.76110286
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74969466
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69804210
22Cardiac muscle contraction_Homo sapiens_hsa042601.64883663
23Huntingtons disease_Homo sapiens_hsa050161.63528027
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.55898099
25RNA polymerase_Homo sapiens_hsa030201.48024290
26Viral myocarditis_Homo sapiens_hsa054161.40324304
27Linoleic acid metabolism_Homo sapiens_hsa005911.22593395
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22181470
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21790622
30T cell receptor signaling pathway_Homo sapiens_hsa046601.17671696
31Staphylococcus aureus infection_Homo sapiens_hsa051501.15500736
32Nitrogen metabolism_Homo sapiens_hsa009101.10835047
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03378430
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00949177
35Homologous recombination_Homo sapiens_hsa034400.97774614
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93587583
37RNA degradation_Homo sapiens_hsa030180.92957997
38Butanoate metabolism_Homo sapiens_hsa006500.89236155
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86488694
40Olfactory transduction_Homo sapiens_hsa047400.85701895
41Systemic lupus erythematosus_Homo sapiens_hsa053220.83555371
42Caffeine metabolism_Homo sapiens_hsa002320.82521474
43Collecting duct acid secretion_Homo sapiens_hsa049660.80948187
44Chemical carcinogenesis_Homo sapiens_hsa052040.79998221
45Peroxisome_Homo sapiens_hsa041460.79183009
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74789680
47Leishmaniasis_Homo sapiens_hsa051400.74633798
48Retinol metabolism_Homo sapiens_hsa008300.74158266
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72958562
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70932061
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.69356877
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.67262896
53Arachidonic acid metabolism_Homo sapiens_hsa005900.65949727
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63936195
55Tryptophan metabolism_Homo sapiens_hsa003800.63716852
56Propanoate metabolism_Homo sapiens_hsa006400.63335246
57Regulation of autophagy_Homo sapiens_hsa041400.62942487
58Sulfur metabolism_Homo sapiens_hsa009200.60928168
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57732934
60Ether lipid metabolism_Homo sapiens_hsa005650.55509879
61Pyrimidine metabolism_Homo sapiens_hsa002400.54826970
62Purine metabolism_Homo sapiens_hsa002300.54607927
63Taste transduction_Homo sapiens_hsa047420.54579860
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.54186943
65One carbon pool by folate_Homo sapiens_hsa006700.52732094
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50116098
67Salivary secretion_Homo sapiens_hsa049700.48332018
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47547071
69Measles_Homo sapiens_hsa051620.47394966
70Malaria_Homo sapiens_hsa051440.47389663
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47380685
72Salmonella infection_Homo sapiens_hsa051320.40968733
73Herpes simplex infection_Homo sapiens_hsa051680.40488992
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40268061
75Nicotine addiction_Homo sapiens_hsa050330.40106812
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.39277460
77Metabolic pathways_Homo sapiens_hsa011000.38674572
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35087984
79Fanconi anemia pathway_Homo sapiens_hsa034600.33248411
80African trypanosomiasis_Homo sapiens_hsa051430.32851738
81Basal transcription factors_Homo sapiens_hsa030220.32714449
82Morphine addiction_Homo sapiens_hsa050320.32505769
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29280824
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28764843
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27594856
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27370891
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25228307
88Fat digestion and absorption_Homo sapiens_hsa049750.23693079
89Legionellosis_Homo sapiens_hsa051340.23332920
90GABAergic synapse_Homo sapiens_hsa047270.21668863
91Nucleotide excision repair_Homo sapiens_hsa034200.21473336
92Spliceosome_Homo sapiens_hsa030400.20566295
93Renin secretion_Homo sapiens_hsa049240.20257384
94Shigellosis_Homo sapiens_hsa051310.19574526
95Tuberculosis_Homo sapiens_hsa051520.19099034
96Ovarian steroidogenesis_Homo sapiens_hsa049130.18742760
97Serotonergic synapse_Homo sapiens_hsa047260.18626815
98Mineral absorption_Homo sapiens_hsa049780.18279383
99ABC transporters_Homo sapiens_hsa020100.18120660
100Pertussis_Homo sapiens_hsa051330.16657327

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »