RPL21P38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.93461393
2ribosomal small subunit biogenesis (GO:0042274)7.11317492
3viral transcription (GO:0019083)6.60795295
4translational termination (GO:0006415)6.48094504
5maturation of SSU-rRNA (GO:0030490)6.01439378
6protein neddylation (GO:0045116)5.50156116
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.38027330
8cotranslational protein targeting to membrane (GO:0006613)5.34483657
9protein targeting to ER (GO:0045047)5.25730440
10translational elongation (GO:0006414)5.23426290
11chaperone-mediated protein transport (GO:0072321)5.22998835
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.21150825
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.08649086
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.89853886
15protein localization to endoplasmic reticulum (GO:0070972)4.89565636
16cellular protein complex disassembly (GO:0043624)4.87831659
17pseudouridine synthesis (GO:0001522)4.72861055
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.62230326
19ATP synthesis coupled proton transport (GO:0015986)4.62230326
20viral life cycle (GO:0019058)4.61997394
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.44673548
22ribosomal large subunit biogenesis (GO:0042273)4.24783367
23translational initiation (GO:0006413)4.22260432
24somite development (GO:0061053)4.18352689
25electron transport chain (GO:0022900)4.13349476
26respiratory electron transport chain (GO:0022904)4.10248785
27protein complex disassembly (GO:0043241)4.05742781
28behavioral response to nicotine (GO:0035095)4.04437135
29nonmotile primary cilium assembly (GO:0035058)3.93796211
30macromolecular complex disassembly (GO:0032984)3.83933757
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.83582843
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.81652640
33protein complex biogenesis (GO:0070271)3.76182674
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.74374648
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.69506287
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.69506287
37NADH dehydrogenase complex assembly (GO:0010257)3.69506287
38tongue development (GO:0043586)3.59497899
39nuclear-transcribed mRNA catabolic process (GO:0000956)3.58598957
40translation (GO:0006412)3.57308837
41mitochondrial respiratory chain complex assembly (GO:0033108)3.46288269
42mRNA catabolic process (GO:0006402)3.44890143
43left/right axis specification (GO:0070986)3.43980853
44chemosensory behavior (GO:0007635)3.43367334
45proteasome assembly (GO:0043248)3.42203153
46negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.41662620
47protein targeting to membrane (GO:0006612)3.39250164
48ribonucleoprotein complex biogenesis (GO:0022613)3.31984026
49cellular component biogenesis (GO:0044085)3.22332811
50RNA catabolic process (GO:0006401)3.12423476
51DNA deamination (GO:0045006)3.11221430
52detection of light stimulus involved in sensory perception (GO:0050962)3.04721833
53detection of light stimulus involved in visual perception (GO:0050908)3.04721833
54regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.00866440
55detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.98116042
56SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.96875560
57response to nitrosative stress (GO:0051409)2.94860760
58cell proliferation in forebrain (GO:0021846)2.94602505
59negative regulation of DNA-templated transcription, elongation (GO:0032785)2.90891537
60regulation of nuclear cell cycle DNA replication (GO:0033262)2.90138891
61termination of RNA polymerase III transcription (GO:0006386)2.89479403
62transcription elongation from RNA polymerase III promoter (GO:0006385)2.89479403
63chromatin remodeling at centromere (GO:0031055)2.88417662
64rRNA processing (GO:0006364)2.88089126
65vocalization behavior (GO:0071625)2.83973132
66mitochondrion morphogenesis (GO:0070584)2.78333946
67rRNA metabolic process (GO:0016072)2.77792823
68retinal ganglion cell axon guidance (GO:0031290)2.75569612
69positive regulation of protein deacetylation (GO:0090312)2.73984501
70negative regulation of telomerase activity (GO:0051974)2.72987545
71aldehyde catabolic process (GO:0046185)2.71048707
72substrate-independent telencephalic tangential migration (GO:0021826)2.69311672
73substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.69311672
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69253855
75spliceosomal complex assembly (GO:0000245)2.68797954
76short-term memory (GO:0007614)2.67486339
77negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.66634373
78detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.65897013
79myoblast migration (GO:0051451)2.65782924
80regulation of mitotic spindle checkpoint (GO:1903504)2.65248624
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65248624
82hydrogen ion transmembrane transport (GO:1902600)2.64936353
83respiratory chain complex IV assembly (GO:0008535)2.64036809
84regulation of non-canonical Wnt signaling pathway (GO:2000050)2.63329116
85regulation of mitochondrial translation (GO:0070129)2.62115661
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61799157
87outer ear morphogenesis (GO:0042473)2.58923148
88cellular ketone body metabolic process (GO:0046950)2.58846128
89regulation of mesoderm development (GO:2000380)2.58321222
90spliceosomal snRNP assembly (GO:0000387)2.55774753
91positive regulation of protein homodimerization activity (GO:0090073)2.55458042
92positive regulation of respiratory burst (GO:0060267)2.53330690
93negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.48751333
94ATP biosynthetic process (GO:0006754)2.47969680
95termination of RNA polymerase II transcription (GO:0006369)2.47652837
96cytochrome complex assembly (GO:0017004)2.47554296
97regulation of cellular respiration (GO:0043457)2.47358063
98telomere maintenance via semi-conservative replication (GO:0032201)2.46146423
99CENP-A containing nucleosome assembly (GO:0034080)2.45497539
100tRNA processing (GO:0008033)2.44062748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05388893
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.32974603
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.06061132
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.83161192
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.72975578
6IGF1R_20145208_ChIP-Seq_DFB_Human2.65543820
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65278966
8FUS_26573619_Chip-Seq_HEK293_Human2.57675237
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48064218
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45439031
11ZNF274_21170338_ChIP-Seq_K562_Hela2.37363199
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.22540388
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17322009
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16991876
15EWS_26573619_Chip-Seq_HEK293_Human2.15342348
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12597871
17IRF1_19129219_ChIP-ChIP_H3396_Human2.10112476
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98294164
19VDR_22108803_ChIP-Seq_LS180_Human1.92968252
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.85510007
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.84332373
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.81601693
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.76443985
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74433398
25ELK1_19687146_ChIP-ChIP_HELA_Human1.72040505
26AR_21572438_ChIP-Seq_LNCaP_Human1.71610683
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68072227
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66519271
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66077129
30MYC_18940864_ChIP-ChIP_HL60_Human1.65772753
31TTF2_22483619_ChIP-Seq_HELA_Human1.55638193
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54732925
33P300_19829295_ChIP-Seq_ESCs_Human1.54194889
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47226322
35GBX2_23144817_ChIP-Seq_PC3_Human1.46640637
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.41981157
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39063777
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38499272
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36438630
40VDR_23849224_ChIP-Seq_CD4+_Human1.35235351
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32174737
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.31679477
43RNF2_27304074_Chip-Seq_NSC_Mouse1.31163177
44HTT_18923047_ChIP-ChIP_STHdh_Human1.30526872
45TP53_22573176_ChIP-Seq_HFKS_Human1.29703706
46FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27092673
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22696734
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22696734
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21713380
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.21274343
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19102523
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18864274
53REST_21632747_ChIP-Seq_MESCs_Mouse1.17527676
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17459521
55CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15155462
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14461877
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14445133
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13212767
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.13177167
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.11877725
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10805866
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10724964
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10708411
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10084983
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09107936
66CBP_20019798_ChIP-Seq_JUKART_Human1.09107936
67FOXP3_21729870_ChIP-Seq_TREG_Human1.05792134
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05419428
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05411994
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.04967587
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03815267
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03431527
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02730686
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01828195
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00979895
76RUNX2_22187159_ChIP-Seq_PCA_Human1.00959693
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00098262
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98946338
79ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97637142
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96986394
81MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96584325
82TCF4_22108803_ChIP-Seq_LS180_Human0.95862470
83ER_23166858_ChIP-Seq_MCF-7_Human0.95334414
84NCOR_22424771_ChIP-Seq_293T_Human0.94381546
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.94357684
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.94308844
87ERG_20517297_ChIP-Seq_VCAP_Human0.94128658
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.94104031
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94104031
90SOX2_19829295_ChIP-Seq_ESCs_Human0.93550604
91NANOG_19829295_ChIP-Seq_ESCs_Human0.93550604
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93206640
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92953472
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92484778
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92368918
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.92306806
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.90587045
98GATA1_26923725_Chip-Seq_HPCs_Mouse0.90369347
99MYC_19829295_ChIP-Seq_ESCs_Human0.90161431
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.89576221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.63502653
2MP0006292_abnormal_olfactory_placode5.43181798
3MP0001293_anophthalmia3.11588520
4MP0010030_abnormal_orbit_morphology2.56062713
5MP0000049_abnormal_middle_ear2.50949189
6MP0000566_synostosis2.37208843
7MP0008877_abnormal_DNA_methylation2.26428827
8MP0003787_abnormal_imprinting2.21822074
9MP0008789_abnormal_olfactory_epithelium2.13483955
10MP0001485_abnormal_pinna_reflex2.12707387
11MP0003122_maternal_imprinting2.09860031
12MP0003567_abnormal_fetal_cardiomyocyte1.99798817
13MP0002234_abnormal_pharynx_morphology1.98688584
14MP0009046_muscle_twitch1.98272251
15MP0005377_hearing/vestibular/ear_phenot1.85242048
16MP0003878_abnormal_ear_physiology1.85242048
17MP0004142_abnormal_muscle_tone1.83788754
18MP0006072_abnormal_retinal_apoptosis1.80534597
19MP0003938_abnormal_ear_development1.80056058
20MP0005174_abnormal_tail_pigmentation1.67652329
21MP0000569_abnormal_digit_pigmentation1.65929284
22MP0003136_yellow_coat_color1.65603428
23MP0002938_white_spotting1.65064190
24MP0000516_abnormal_urinary_system1.61553875
25MP0005367_renal/urinary_system_phenotyp1.61553875
26MP0002102_abnormal_ear_morphology1.59315626
27MP0002254_reproductive_system_inflammat1.59177543
28MP0003693_abnormal_embryo_hatching1.57736686
29MP0005499_abnormal_olfactory_system1.52383552
30MP0005394_taste/olfaction_phenotype1.52383552
31MP0001968_abnormal_touch/_nociception1.51848222
32MP0006276_abnormal_autonomic_nervous1.51079608
33MP0003121_genomic_imprinting1.50439026
34MP0002233_abnormal_nose_morphology1.49070256
35MP0003880_abnormal_central_pattern1.40533267
36MP0002736_abnormal_nociception_after1.39790694
37MP0000631_abnormal_neuroendocrine_gland1.39538595
38MP0001348_abnormal_lacrimal_gland1.38703127
39MP0002138_abnormal_hepatobiliary_system1.36950233
40MP0001501_abnormal_sleep_pattern1.35965913
41MP0002272_abnormal_nervous_system1.34420897
42MP0001486_abnormal_startle_reflex1.30335966
43MP0002735_abnormal_chemical_nociception1.29067692
44MP0003183_abnormal_peptide_metabolism1.25736093
45MP0005253_abnormal_eye_physiology1.25158053
46MP0005670_abnormal_white_adipose1.23483123
47MP0008872_abnormal_physiological_respon1.23308911
48MP0005551_abnormal_eye_electrophysiolog1.23234943
49MP0002572_abnormal_emotion/affect_behav1.22006117
50MP0003123_paternal_imprinting1.21729306
51MP0000026_abnormal_inner_ear1.13866214
52MP0003941_abnormal_skin_development1.13798123
53MP0005391_vision/eye_phenotype1.13664343
54MP0002277_abnormal_respiratory_mucosa1.12874627
55MP0000778_abnormal_nervous_system1.12864345
56MP0005084_abnormal_gallbladder_morpholo1.11667791
57MP0002249_abnormal_larynx_morphology1.09900208
58MP0001905_abnormal_dopamine_level1.08700289
59MP0008569_lethality_at_weaning1.06103752
60MP0001286_abnormal_eye_development1.06056148
61MP0004742_abnormal_vestibular_system1.04694984
62MP0001970_abnormal_pain_threshold1.03662699
63MP0002638_abnormal_pupillary_reflex1.03326712
64MP0001984_abnormal_olfaction1.03025730
65MP0009745_abnormal_behavioral_response1.02806201
66MP0002752_abnormal_somatic_nervous1.01960287
67MP0002557_abnormal_social/conspecific_i1.00757539
68MP0009250_abnormal_appendicular_skeleto0.99740077
69MP0003718_maternal_effect0.99634955
70MP0003937_abnormal_limbs/digits/tail_de0.99427759
71MP0003646_muscle_fatigue0.99386588
72MP0003195_calcinosis0.99261641
73MP0000762_abnormal_tongue_morphology0.98270677
74MP0000678_abnormal_parathyroid_gland0.98179306
75MP0002095_abnormal_skin_pigmentation0.97762636
76MP0005195_abnormal_posterior_eye0.95940173
77MP0004133_heterotaxia0.95115682
78MP0002733_abnormal_thermal_nociception0.95111803
79MP0000955_abnormal_spinal_cord0.92814822
80MP0002184_abnormal_innervation0.89533945
81MP0002932_abnormal_joint_morphology0.88253173
82MP0002111_abnormal_tail_morphology0.87667238
83MP0003635_abnormal_synaptic_transmissio0.87157590
84MP0003890_abnormal_embryonic-extraembry0.86841767
85MP0002067_abnormal_sensory_capabilities0.86631475
86MP0003119_abnormal_digestive_system0.85845260
87MP0003755_abnormal_palate_morphology0.85747840
88MP0001963_abnormal_hearing_physiology0.84491917
89MP0001440_abnormal_grooming_behavior0.82546064
90MP0002092_abnormal_eye_morphology0.82440757
91MP0001529_abnormal_vocalization0.81196934
92MP0004859_abnormal_synaptic_plasticity0.80610027
93MP0002063_abnormal_learning/memory/cond0.77020360
94MP0003936_abnormal_reproductive_system0.75794714
95MP0008058_abnormal_DNA_repair0.74595485
96MP0002697_abnormal_eye_size0.74098984
97MP0001270_distended_abdomen0.73997774
98MP0001502_abnormal_circadian_rhythm0.73680105
99MP0002064_seizures0.72038360
100MP0002152_abnormal_brain_morphology0.71174142

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)7.21817694
2Abnormality of midbrain morphology (HP:0002418)4.65932481
3Molar tooth sign on MRI (HP:0002419)4.65932481
4Pancreatic fibrosis (HP:0100732)4.54928666
5Rib fusion (HP:0000902)4.32624707
6Acute necrotizing encephalopathy (HP:0006965)4.07719301
7Bile duct proliferation (HP:0001408)3.94556005
8Abnormal biliary tract physiology (HP:0012439)3.94556005
9Failure to thrive in infancy (HP:0001531)3.69954651
10True hermaphroditism (HP:0010459)3.57616318
11Abnormal mitochondria in muscle tissue (HP:0008316)3.49251950
12Macrocytic anemia (HP:0001972)3.48137583
13Pancreatic cysts (HP:0001737)3.43826237
14Abnormality of cells of the erythroid lineage (HP:0012130)3.42161622
15Acute encephalopathy (HP:0006846)3.38662313
16Septo-optic dysplasia (HP:0100842)3.34353567
17Progressive macrocephaly (HP:0004481)3.34314930
18Pallor (HP:0000980)3.34016776
19Febrile seizures (HP:0002373)3.26447135
20Aplasia/Hypoplasia of the sacrum (HP:0008517)3.17015222
21Sclerocornea (HP:0000647)3.13533982
22Bifid tongue (HP:0010297)3.07622653
23Nephronophthisis (HP:0000090)2.95140181
24Mitochondrial inheritance (HP:0001427)2.86391374
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80556247
26Chromsome breakage (HP:0040012)2.78707234
27Absent thumb (HP:0009777)2.73896916
28Abnormal number of erythroid precursors (HP:0012131)2.71219822
29Congenital stationary night blindness (HP:0007642)2.70628553
30Aplasia/Hypoplasia of the spleen (HP:0010451)2.69690889
31Confusion (HP:0001289)2.67922025
32Increased hepatocellular lipid droplets (HP:0006565)2.65103867
33Asplenia (HP:0001746)2.64625791
34Abnormality of DNA repair (HP:0003254)2.63912555
35Congenital, generalized hypertrichosis (HP:0004540)2.61487723
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.57843965
37Cystic liver disease (HP:0006706)2.55659846
38Anophthalmia (HP:0000528)2.52833671
39Cerebral edema (HP:0002181)2.51308941
40Lipid accumulation in hepatocytes (HP:0006561)2.46986825
41Increased CSF lactate (HP:0002490)2.44353756
42Medial flaring of the eyebrow (HP:0010747)2.42093961
43Colon cancer (HP:0003003)2.41549701
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40306502
45Abnormality of the renal collecting system (HP:0004742)2.38513360
46Pendular nystagmus (HP:0012043)2.35237349
47Anencephaly (HP:0002323)2.35184774
48Supernumerary spleens (HP:0009799)2.33785326
49Agitation (HP:0000713)2.31900833
50Abnormality of the renal medulla (HP:0100957)2.30769110
51Stenosis of the external auditory canal (HP:0000402)2.29179953
52Depressed nasal ridge (HP:0000457)2.22171940
53Missing ribs (HP:0000921)2.20176934
54Tachypnea (HP:0002789)2.19885356
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.19769746
56Narrow forehead (HP:0000341)2.17806377
57Ectopic kidney (HP:0000086)2.15043616
58Abnormality of the phalanges of the 5th finger (HP:0004213)2.14843136
59Triphalangeal thumb (HP:0001199)2.11716765
60Focal motor seizures (HP:0011153)2.08858708
61Postaxial foot polydactyly (HP:0001830)2.07889006
62Synostosis of carpal bones (HP:0005048)2.07124247
63Growth hormone deficiency (HP:0000824)2.06719453
64Bilateral microphthalmos (HP:0007633)2.06399528
65Meckel diverticulum (HP:0002245)2.06272733
66Parakeratosis (HP:0001036)2.05894946
67Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.04025652
68Abnormal ciliary motility (HP:0012262)1.99308089
69Duplicated collecting system (HP:0000081)1.98980730
70Abnormality of reticulocytes (HP:0004312)1.98792119
71Gait imbalance (HP:0002141)1.96972162
72Myokymia (HP:0002411)1.92516348
73Abnormality of the ileum (HP:0001549)1.92505821
74Male pseudohermaphroditism (HP:0000037)1.92100368
75Increased intramyocellular lipid droplets (HP:0012240)1.91385123
76Abolished electroretinogram (ERG) (HP:0000550)1.91092068
77Maternal diabetes (HP:0009800)1.90595110
78Optic nerve hypoplasia (HP:0000609)1.86126050
79Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.85907113
80Congenital primary aphakia (HP:0007707)1.85865184
81Esophageal atresia (HP:0002032)1.85288044
82Optic disc pallor (HP:0000543)1.84802767
83Restlessness (HP:0000711)1.84781163
84Cutaneous finger syndactyly (HP:0010554)1.82393006
85Small hand (HP:0200055)1.82129735
86Abnormal rod and cone electroretinograms (HP:0008323)1.81110180
87Absent septum pellucidum (HP:0001331)1.80416306
88Holoprosencephaly (HP:0001360)1.80123087
89Oligodactyly (HP:0012165)1.79137604
90Renal Fanconi syndrome (HP:0001994)1.78512827
91Postaxial hand polydactyly (HP:0001162)1.78143934
92Median cleft lip (HP:0000161)1.77348954
93High anterior hairline (HP:0009890)1.76466808
94Abnormal respiratory motile cilium physiology (HP:0012261)1.76311611
95Genital tract atresia (HP:0001827)1.74845755
96Vaginal atresia (HP:0000148)1.73960869
97Symphalangism affecting the phalanges of the hand (HP:0009773)1.73957100
98Hemivertebrae (HP:0002937)1.72117254
99Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.70492266
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69519176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.66543077
2GRK14.30101934
3ADRBK23.91624332
4WNK43.41231890
5MAP3K42.97778096
6TAF12.83942014
7TNIK2.81123279
8FGFR32.59818986
9CDC72.49666634
10TRIM282.45369177
11MAP2K72.35272264
12VRK22.25110406
13WNK32.20843854
14PINK12.07482983
15DYRK1A2.02264881
16NUAK11.91770611
17DYRK21.91057749
18STK391.88637012
19NME11.84821042
20EPHB21.77001606
21BUB11.72313731
22OXSR11.61933962
23FRK1.44641841
24PNCK1.34240869
25MAP3K61.29066804
26MAP2K41.19474843
27STK161.17612935
28VRK11.17099005
29PLK21.16478669
30NTRK21.13717866
31ADRBK11.05304110
32PLK10.97146946
33PRKCG0.97093250
34PDK20.97004510
35MAP4K20.96555397
36PRKG20.86973213
37PIK3CA0.85706141
38MAPK130.83995442
39LRRK20.83202768
40MAP3K110.81819430
41SRPK10.79942132
42CHEK20.79799620
43BMPR1B0.77693441
44TLK10.75120733
45MAP3K50.73075326
46PLK40.71553857
47STK240.71316042
48PLK30.71177117
49CSNK1G10.69500497
50STK38L0.68711946
51MINK10.68666628
52CSNK1E0.67961206
53PRKCE0.65634873
54ATR0.64256289
55EPHA30.61833937
56SGK10.61405393
57MAPK120.61278389
58TIE10.59931906
59PRKACA0.59876266
60TEC0.59480657
61NLK0.58761250
62CSNK2A20.57731157
63INSRR0.56722293
64CDK30.56704561
65MARK10.56338944
66CSNK1G20.55644192
67WEE10.55537473
68CSNK1A10.55224796
69OBSCN0.54607339
70ATM0.51083589
71NME20.50610085
72CAMK2A0.50560752
73MAPK150.49969399
74AURKB0.48155122
75PRKDC0.48069227
76MAPK70.47235274
77CASK0.46705550
78CAMK10.46336458
79CSNK1G30.46035252
80PASK0.44269254
81PRKACB0.43893597
82PRKCI0.43213111
83BCR0.42636763
84ZAK0.39353905
85CSNK2A10.39306260
86CSNK1D0.38916188
87BCKDK0.38570096
88INSR0.37640981
89LATS10.36735839
90AURKA0.36423929
91CAMKK10.36168695
92PRKCQ0.36110378
93CDK20.32926806
94PRKCA0.32829213
95CAMK2D0.32709332
96NTRK10.31772427
97PBK0.29274092
98ITK0.28683414
99AKT20.26883128
100TXK0.26385874

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.70263951
2Oxidative phosphorylation_Homo sapiens_hsa001903.78275419
3Parkinsons disease_Homo sapiens_hsa050123.26623631
4Cardiac muscle contraction_Homo sapiens_hsa042602.73663221
5RNA polymerase_Homo sapiens_hsa030202.54354820
6Huntingtons disease_Homo sapiens_hsa050162.36502116
7Alzheimers disease_Homo sapiens_hsa050102.19961495
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16707324
9RNA degradation_Homo sapiens_hsa030182.12192489
10DNA replication_Homo sapiens_hsa030302.05008186
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95387639
12Taste transduction_Homo sapiens_hsa047421.95034485
13Mismatch repair_Homo sapiens_hsa034301.93447531
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92790800
15Homologous recombination_Homo sapiens_hsa034401.91336748
16Propanoate metabolism_Homo sapiens_hsa006401.85172404
17Phototransduction_Homo sapiens_hsa047441.83058461
18Pyruvate metabolism_Homo sapiens_hsa006201.76757493
19Spliceosome_Homo sapiens_hsa030401.63542794
20Protein export_Homo sapiens_hsa030601.57789631
21Linoleic acid metabolism_Homo sapiens_hsa005911.56464771
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56279520
23Nucleotide excision repair_Homo sapiens_hsa034201.43776358
24Fanconi anemia pathway_Homo sapiens_hsa034601.43263186
25Basal transcription factors_Homo sapiens_hsa030221.41192032
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41032717
27Base excision repair_Homo sapiens_hsa034101.38885358
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.38625660
29Hedgehog signaling pathway_Homo sapiens_hsa043401.38406174
30Proteasome_Homo sapiens_hsa030501.36727202
31Olfactory transduction_Homo sapiens_hsa047401.27956130
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23840519
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22657183
34Basal cell carcinoma_Homo sapiens_hsa052171.22048445
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22033096
36Pyrimidine metabolism_Homo sapiens_hsa002401.21362295
37Nicotine addiction_Homo sapiens_hsa050331.20504731
38Caffeine metabolism_Homo sapiens_hsa002321.18318387
39One carbon pool by folate_Homo sapiens_hsa006701.17625493
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16167376
41Vitamin B6 metabolism_Homo sapiens_hsa007501.15632520
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14871121
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13967703
44Butanoate metabolism_Homo sapiens_hsa006501.11505915
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06892407
46Chemical carcinogenesis_Homo sapiens_hsa052041.05188780
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00420846
48Purine metabolism_Homo sapiens_hsa002300.97943053
49Peroxisome_Homo sapiens_hsa041460.93471031
50Ether lipid metabolism_Homo sapiens_hsa005650.93178307
51Vitamin digestion and absorption_Homo sapiens_hsa049770.92654576
52Nitrogen metabolism_Homo sapiens_hsa009100.90871128
53Retinol metabolism_Homo sapiens_hsa008300.85699598
54RNA transport_Homo sapiens_hsa030130.83095102
55Tryptophan metabolism_Homo sapiens_hsa003800.79392846
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78127950
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77233590
58beta-Alanine metabolism_Homo sapiens_hsa004100.75978843
59Morphine addiction_Homo sapiens_hsa050320.73916668
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72171170
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71919133
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.71842584
63Serotonergic synapse_Homo sapiens_hsa047260.69973293
64Metabolic pathways_Homo sapiens_hsa011000.66591301
65Glutamatergic synapse_Homo sapiens_hsa047240.66576214
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62604808
67Steroid biosynthesis_Homo sapiens_hsa001000.62565785
68Arachidonic acid metabolism_Homo sapiens_hsa005900.62440949
69Folate biosynthesis_Homo sapiens_hsa007900.61412922
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61001458
71Glycerolipid metabolism_Homo sapiens_hsa005610.60433518
72Salivary secretion_Homo sapiens_hsa049700.59032383
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58816270
74Fat digestion and absorption_Homo sapiens_hsa049750.57957648
75Ovarian steroidogenesis_Homo sapiens_hsa049130.51429796
76GABAergic synapse_Homo sapiens_hsa047270.50836037
77Circadian entrainment_Homo sapiens_hsa047130.48357874
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42461889
79Long-term depression_Homo sapiens_hsa047300.41999004
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41745367
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.39872958
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38937309
83Primary immunodeficiency_Homo sapiens_hsa053400.36517363
84Arginine and proline metabolism_Homo sapiens_hsa003300.34999638
85Collecting duct acid secretion_Homo sapiens_hsa049660.33881489
86mRNA surveillance pathway_Homo sapiens_hsa030150.32170372
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31914618
88Insulin secretion_Homo sapiens_hsa049110.31275863
89Histidine metabolism_Homo sapiens_hsa003400.30929876
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30899406
91Selenocompound metabolism_Homo sapiens_hsa004500.30304024
92Fatty acid degradation_Homo sapiens_hsa000710.28528337
93Wnt signaling pathway_Homo sapiens_hsa043100.24667197
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.22483250
95Cholinergic synapse_Homo sapiens_hsa047250.21268400
96Hippo signaling pathway_Homo sapiens_hsa043900.18972566
97Glutathione metabolism_Homo sapiens_hsa004800.17279758
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.15600007
99Non-homologous end-joining_Homo sapiens_hsa034500.14008527
100Dopaminergic synapse_Homo sapiens_hsa047280.13462357

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