ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.98093566
2	DNA deamination (GO:0045006)	5.59988635
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.41036753
4	ATP synthesis coupled proton transport (GO:0015986)	5.41036753
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.17020403
6	viral transcription (GO:0019083)	4.87204575
7	cytidine metabolic process (GO:0046087)	4.73799459
8	cytidine catabolic process (GO:0006216)	4.73799459
9	cytidine deamination (GO:0009972)	4.73799459
10	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.73360201
11	translational termination (GO:0006415)	4.65992481
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.48875210
13	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.36845552
14	maturation of SSU-rRNA (GO:0030490)	4.36805666
15	cotranslational protein targeting to membrane (GO:0006613)	4.29783033
16	protein targeting to ER (GO:0045047)	4.25278156
17	translational elongation (GO:0006414)	4.13399007
18	protein localization to endoplasmic reticulum (GO:0070972)	4.11024689
19	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.07661720
20	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.07661720
21	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.05768740
22	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.00991104
23	respiratory electron transport chain (GO:0022904)	3.96210109
24	electron transport chain (GO:0022900)	3.96201900
25	protein neddylation (GO:0045116)	3.92106153
26	protein complex biogenesis (GO:0070271)	3.66302226
27	viral life cycle (GO:0019058)	3.43389423
28	cellular protein complex disassembly (GO:0043624)	3.41989235
29	ribosomal small subunit biogenesis (GO:0042274)	3.37950231
30	water-soluble vitamin biosynthetic process (GO:0042364)	3.25089374
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.22324023
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.20482199
33	NADH dehydrogenase complex assembly (GO:0010257)	3.20482199
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.20482199
35	ribosomal large subunit biogenesis (GO:0042273)	3.20052661
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.19948375
37	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.18363663
38	behavioral response to nicotine (GO:0035095)	3.17677194
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.16824153
40	cellular response to interleukin-15 (GO:0071350)	3.16243550
41	ATP biosynthetic process (GO:0006754)	3.13507699
42	hydrogen ion transmembrane transport (GO:1902600)	3.09517445
43	translational initiation (GO:0006413)	3.09443553
44	translation (GO:0006412)	3.07376165
45	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.04446096
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.01245181
47	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.98301524
48	interferon-gamma production (GO:0032609)	2.97632124
49	proton transport (GO:0015992)	2.97415036
50	chaperone-mediated protein transport (GO:0072321)	2.96228060
51	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.93437516
52	proteasome assembly (GO:0043248)	2.92867027
53	regulation of chronic inflammatory response (GO:0002676)	2.92069105
54	hydrogen transport (GO:0006818)	2.91576725
55	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.90577861
56	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.89730837
57	termination of RNA polymerase III transcription (GO:0006386)	2.89504052
58	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.89504052
59	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.88023175
60	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.86846341
61	actin nucleation (GO:0045010)	2.82347747
62	regulation of T cell mediated cytotoxicity (GO:0001914)	2.80268664
63	mannosylation (GO:0097502)	2.78804528
64	regulation of activation of Janus kinase activity (GO:0010533)	2.77432047
65	protein targeting to membrane (GO:0006612)	2.76177236
66	regulation of regulatory T cell differentiation (GO:0045589)	2.74984091
67	protein complex disassembly (GO:0043241)	2.74484786
68	indolalkylamine catabolic process (GO:0046218)	2.73699390
69	tryptophan catabolic process (GO:0006569)	2.73699390
70	indole-containing compound catabolic process (GO:0042436)	2.73699390
71	kynurenine metabolic process (GO:0070189)	2.73253938
72	S-adenosylmethionine metabolic process (GO:0046500)	2.72304917
73	positive regulation of defense response to virus by host (GO:0002230)	2.70841714
74	respiratory chain complex IV assembly (GO:0008535)	2.69858368
75	indolalkylamine metabolic process (GO:0006586)	2.68579379
76	mast cell activation (GO:0045576)	2.68162069
77	adaptation of signaling pathway (GO:0023058)	2.68118585
78	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.66518737
79	platelet dense granule organization (GO:0060155)	2.66351542
80	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.65803713
81	cytochrome complex assembly (GO:0017004)	2.63876951
82	protein-cofactor linkage (GO:0018065)	2.62904444
83	macromolecular complex disassembly (GO:0032984)	2.62661405
84	regulation of isotype switching to IgG isotypes (GO:0048302)	2.62328985
85	GPI anchor metabolic process (GO:0006505)	2.59790828
86	regulation of interleukin-8 secretion (GO:2000482)	2.58565315
87	pseudouridine synthesis (GO:0001522)	2.57499761
88	regulation of cellular amino acid metabolic process (GO:0006521)	2.56602943
89	rRNA catabolic process (GO:0016075)	2.54927066
90	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.53383851
91	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.51713929
92	negative regulation of T cell differentiation in thymus (GO:0033085)	2.51419176
93	axoneme assembly (GO:0035082)	2.50817711
94	negative regulation of mast cell activation (GO:0033004)	2.50363817
95	piRNA metabolic process (GO:0034587)	2.49739304
96	positive regulation of prostaglandin secretion (GO:0032308)	2.48903872
97	regulation of T cell receptor signaling pathway (GO:0050856)	2.47552612
98	somite development (GO:0061053)	2.46004386
99	negative regulation of heart rate (GO:0010459)	2.43768567
100	GPI anchor biosynthetic process (GO:0006506)	2.42795351

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.69405479
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.65659672
3	VDR_22108803_ChIP-Seq_LS180_Human	2.94417356
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.92839175
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.88779087
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.84039414
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.81287566
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.66987358
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.63207791
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.41634247
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.37483503
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.30013819
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.24168461
14	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.22967117
15	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.11540063
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.09707538
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.08540978
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.06294712
19	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.00139596
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.97633823
21	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.95741434
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.84365089
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81396137
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.74130365
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.72740093
26	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.69311189
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.65964360
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65435766
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.62453846
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61145572
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.58356394
32	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.56659407
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49534966
34	AR_20517297_ChIP-Seq_VCAP_Human	1.49458450
35	GATA3_26560356_Chip-Seq_TH2_Human	1.47866114
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.45462726
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.45462726
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.44584831
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41873921
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.40951531
41	EWS_26573619_Chip-Seq_HEK293_Human	1.40768521
42	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.39448706
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.39201647
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34222164
45	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.31684430
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27779622
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23658062
48	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22766986
49	NCOR_22424771_ChIP-Seq_293T_Human	1.22159066
50	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.21298804
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19256239
52	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18928588
53	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.18881506
54	RUNX_20019798_ChIP-Seq_JUKART_Human	1.18784556
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18591580
56	FUS_26573619_Chip-Seq_HEK293_Human	1.17413649
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.16569300
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16569300
59	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16483215
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16187441
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16106112
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16106112
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.15534241
64	MYB_26560356_Chip-Seq_TH2_Human	1.15146730
65	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.14302465
66	P300_19829295_ChIP-Seq_ESCs_Human	1.13902315
67	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13697664
68	ER_23166858_ChIP-Seq_MCF-7_Human	1.12196716
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.11479644
70	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.11445218
71	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11410158
72	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11208023
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10435031
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10177844
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10120655
76	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.08439354
77	ERG_20517297_ChIP-Seq_VCAP_Human	1.08279864
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07959145
79	MYC_19829295_ChIP-Seq_ESCs_Human	1.07876864
80	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05594610
81	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.05486619
82	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.05177676
83	GATA3_27048872_Chip-Seq_THYMUS_Human	1.03840356
84	TAF15_26573619_Chip-Seq_HEK293_Human	1.02538328
85	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02436315
86	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.00713118
87	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.00619506
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.98491801
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97336844
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97217352
91	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.96814773
92	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95875616
93	BCL6_27268052_Chip-Seq_Bcells_Human	0.95435059
94	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.95322252
95	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.95317718
96	ERA_21632823_ChIP-Seq_H3396_Human	0.94774239
97	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.94403064
98	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.94355004
99	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93049547
100	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92639410

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.25437387
2	MP0009379_abnormal_foot_pigmentation	3.69093833
3	MP0001835_abnormal_antigen_presentation	2.95419724
4	MP0008877_abnormal_DNA_methylation	2.90434261
5	MP0006292_abnormal_olfactory_placode	2.60025912
6	MP0006072_abnormal_retinal_apoptosis	2.40900112
7	MP0003787_abnormal_imprinting	2.33882930
8	MP0008872_abnormal_physiological_respon	2.26279673
9	MP0009785_altered_susceptibility_to	2.16497193
10	MP0004147_increased_porphyrin_level	2.10412840
11	MP0002102_abnormal_ear_morphology	2.04657888
12	MP0005377_hearing/vestibular/ear_phenot	1.99884429
13	MP0003878_abnormal_ear_physiology	1.99884429
14	MP0008875_abnormal_xenobiotic_pharmacok	1.97802115
15	MP0004142_abnormal_muscle_tone	1.92137685
16	MP0004885_abnormal_endolymph	1.84482624
17	MP0005645_abnormal_hypothalamus_physiol	1.81585977
18	MP0001800_abnormal_humoral_immune	1.77587360
19	MP0002876_abnormal_thyroid_physiology	1.73974307
20	MP0003646_muscle_fatigue	1.73009875
21	MP0000372_irregular_coat_pigmentation	1.72908728
22	MP0002148_abnormal_hypersensitivity_rea	1.70809885
23	MP0002163_abnormal_gland_morphology	1.70323437
24	MP0001968_abnormal_touch/_nociception	1.69226565
25	MP0000685_abnormal_immune_system	1.66549011
26	MP0003195_calcinosis	1.65611584
27	MP0005000_abnormal_immune_tolerance	1.64971388
28	MP0005646_abnormal_pituitary_gland	1.62252840
29	MP0005075_abnormal_melanosome_morpholog	1.62166015
30	MP0002837_dystrophic_cardiac_calcinosis	1.61405796
31	MP0002736_abnormal_nociception_after	1.61215666
32	MP0005551_abnormal_eye_electrophysiolog	1.59474490
33	MP0001986_abnormal_taste_sensitivity	1.55857077
34	MP0001919_abnormal_reproductive_system	1.54882611
35	MP0002138_abnormal_hepatobiliary_system	1.48763804
36	MP0001873_stomach_inflammation	1.48569963
37	MP0003011_delayed_dark_adaptation	1.48428993
38	MP0002723_abnormal_immune_serum	1.47369579
39	MP0003763_abnormal_thymus_physiology	1.45936210
40	MP0005387_immune_system_phenotype	1.43077875
41	MP0001790_abnormal_immune_system	1.43077875
42	MP0002234_abnormal_pharynx_morphology	1.36739745
43	MP0002166_altered_tumor_susceptibility	1.36323750
44	MP0002420_abnormal_adaptive_immunity	1.36140460
45	MP0003866_abnormal_defecation	1.34411327
46	MP0004145_abnormal_muscle_electrophysio	1.33652856
47	MP0001819_abnormal_immune_cell	1.33614142
48	MP0003806_abnormal_nucleotide_metabolis	1.33259053
49	MP0005253_abnormal_eye_physiology	1.33112891
50	MP0001905_abnormal_dopamine_level	1.32898696
51	MP0005389_reproductive_system_phenotype	1.32313719
52	MP0003786_premature_aging	1.28049598
53	MP0008789_abnormal_olfactory_epithelium	1.27118005
54	MP0002452_abnormal_antigen_presenting	1.26605089
55	MP0002006_tumorigenesis	1.20582259
56	MP0005025_abnormal_response_to	1.19638887
57	MP0006276_abnormal_autonomic_nervous	1.16549892
58	MP0009764_decreased_sensitivity_to	1.13393440
59	MP0002272_abnormal_nervous_system	1.10669505
60	MP0009333_abnormal_splenocyte_physiolog	1.09271335
61	MP0005379_endocrine/exocrine_gland_phen	1.08402382
62	MP0001348_abnormal_lacrimal_gland	1.07248634
63	MP0003880_abnormal_central_pattern	1.05070760
64	MP0002095_abnormal_skin_pigmentation	1.04484715
65	MP0004742_abnormal_vestibular_system	1.04148730
66	MP0002277_abnormal_respiratory_mucosa	1.02538071
67	MP0001485_abnormal_pinna_reflex	1.01681153
68	MP0009745_abnormal_behavioral_response	0.98639483
69	MP0006082_CNS_inflammation	0.98574859
70	MP0000716_abnormal_immune_system	0.96795316
71	MP0002638_abnormal_pupillary_reflex	0.96512047
72	MP0010386_abnormal_urinary_bladder	0.94829280
73	MP0005636_abnormal_mineral_homeostasis	0.92596405
74	MP0001529_abnormal_vocalization	0.92127473
75	MP0001845_abnormal_inflammatory_respons	0.91634442
76	MP0000631_abnormal_neuroendocrine_gland	0.91316583
77	MP0002405_respiratory_system_inflammati	0.89884610
78	MP0006036_abnormal_mitochondrial_physio	0.89139459
79	MP0002398_abnormal_bone_marrow	0.88572551
80	MP0002693_abnormal_pancreas_physiology	0.88089507
81	MP0005084_abnormal_gallbladder_morpholo	0.87887289
82	MP0001970_abnormal_pain_threshold	0.86003754
83	MP0002933_joint_inflammation	0.85697821
84	MP0003122_maternal_imprinting	0.85085713
85	MP0002160_abnormal_reproductive_system	0.84712804
86	MP0005410_abnormal_fertilization	0.84056838
87	MP0003724_increased_susceptibility_to	0.83746695
88	MP0010155_abnormal_intestine_physiology	0.81790136
89	MP0001984_abnormal_olfaction	0.81309674
90	MP0001440_abnormal_grooming_behavior	0.81278160
91	MP0000689_abnormal_spleen_morphology	0.80091286
92	MP0001963_abnormal_hearing_physiology	0.79858550
93	MP0003436_decreased_susceptibility_to	0.79827597
94	MP0002653_abnormal_ependyma_morphology	0.75304823
95	MP0001765_abnormal_ion_homeostasis	0.74376845
96	MP0003186_abnormal_redox_activity	0.73232083
97	MP0008995_early_reproductive_senescence	0.72772351
98	MP0003121_genomic_imprinting	0.72736827
99	MP0002733_abnormal_thermal_nociception	0.72391237
100	MP0005394_taste/olfaction_phenotype	0.72286841

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.72596215
2	Mitochondrial inheritance (HP:0001427)	4.34867346
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.18370804
4	Acute encephalopathy (HP:0006846)	3.98860800
5	IgG deficiency (HP:0004315)	3.95054383
6	Progressive macrocephaly (HP:0004481)	3.93573432
7	Hepatocellular necrosis (HP:0001404)	3.79892073
8	Increased CSF lactate (HP:0002490)	3.77827167
9	Increased hepatocellular lipid droplets (HP:0006565)	3.50274481
10	Congenital stationary night blindness (HP:0007642)	3.44078176
11	Lipid accumulation in hepatocytes (HP:0006561)	3.42445177
12	Reticulocytopenia (HP:0001896)	3.36363708
13	Hepatic necrosis (HP:0002605)	3.29058882
14	Hypoproteinemia (HP:0003075)	3.16938634
15	Severe combined immunodeficiency (HP:0004430)	3.16742895
16	Pancreatic cysts (HP:0001737)	3.15172248
17	Aplastic anemia (HP:0001915)	3.13440504
18	Abnormality of cells of the erythroid lineage (HP:0012130)	3.06863558
19	Renal Fanconi syndrome (HP:0001994)	3.01139554
20	3-Methylglutaconic aciduria (HP:0003535)	2.99517639
21	Elevated erythrocyte sedimentation rate (HP:0003565)	2.94695508
22	Cerebral edema (HP:0002181)	2.83922950
23	Molar tooth sign on MRI (HP:0002419)	2.81472506
24	Abnormality of midbrain morphology (HP:0002418)	2.81472506
25	Congenital, generalized hypertrichosis (HP:0004540)	2.80893000
26	Increased intramyocellular lipid droplets (HP:0012240)	2.79735359
27	Abnormal number of erythroid precursors (HP:0012131)	2.65560289
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.64873065
29	Thyroiditis (HP:0100646)	2.64354318
30	Optic disc pallor (HP:0000543)	2.64096729
31	Pancreatic fibrosis (HP:0100732)	2.59091498
32	Macrocytic anemia (HP:0001972)	2.56416919
33	Abnormality of B cell number (HP:0010975)	2.51751520
34	Abnormality of T cell number (HP:0011839)	2.51420279
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.46588241
36	T lymphocytopenia (HP:0005403)	2.46119897
37	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.44148420
38	Increased muscle lipid content (HP:0009058)	2.43814591
39	Abnormality of the renal cortex (HP:0011035)	2.43695687
40	Absent thumb (HP:0009777)	2.40732459
41	Nephronophthisis (HP:0000090)	2.39271868
42	True hermaphroditism (HP:0010459)	2.38450258
43	Exertional dyspnea (HP:0002875)	2.36379783
44	Increased IgM level (HP:0003496)	2.32425076
45	Stomatitis (HP:0010280)	2.32326829
46	Combined immunodeficiency (HP:0005387)	2.29495127
47	Abnormality of T cells (HP:0002843)	2.28964329
48	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.28953664
49	Abolished electroretinogram (ERG) (HP:0000550)	2.28826150
50	Asplenia (HP:0001746)	2.26877983
51	Increased serum lactate (HP:0002151)	2.26831400
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.25283801
53	Methylmalonic acidemia (HP:0002912)	2.23354578
54	Sclerocornea (HP:0000647)	2.22281050
55	Lactic acidosis (HP:0003128)	2.18282122
56	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.16951491
57	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.16951491
58	Abnormal drinking behavior (HP:0030082)	2.14487401
59	Polydipsia (HP:0001959)	2.14487401
60	Pallor (HP:0000980)	2.14428684
61	Abnormality of DNA repair (HP:0003254)	2.12979332
62	Leukodystrophy (HP:0002415)	2.12860311
63	Abnormality of the prostate (HP:0008775)	2.11174637
64	Abnormality of the renal medulla (HP:0100957)	2.08431053
65	Respiratory failure (HP:0002878)	2.07908158
66	Attenuation of retinal blood vessels (HP:0007843)	2.07170611
67	Abnormality of eosinophils (HP:0001879)	2.06365349
68	Abnormality of renal resorption (HP:0011038)	2.05206047
69	B lymphocytopenia (HP:0010976)	2.04978664
70	Aplasia/hypoplasia of the uterus (HP:0008684)	2.04755443
71	Medial flaring of the eyebrow (HP:0010747)	2.03508846
72	Lethargy (HP:0001254)	2.01861415
73	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.00189628
74	Chronic diarrhea (HP:0002028)	1.97079576
75	Pancytopenia (HP:0001876)	1.94845538
76	Stenosis of the external auditory canal (HP:0000402)	1.94303886
77	Renal cortical cysts (HP:0000803)	1.92049250
78	Abnormality of urine glucose concentration (HP:0011016)	1.90674882
79	Glycosuria (HP:0003076)	1.90674882
80	Autoimmune hemolytic anemia (HP:0001890)	1.90018490
81	Polyuria (HP:0000103)	1.88522066
82	Abnormal albumin level (HP:0012116)	1.88136501
83	Hypoalbuminemia (HP:0003073)	1.88136501
84	Panhypogammaglobulinemia (HP:0003139)	1.87619508
85	Cystic liver disease (HP:0006706)	1.86363950
86	Type II lissencephaly (HP:0007260)	1.80420044
87	Colon cancer (HP:0003003)	1.78106819
88	Abnormality of T cell physiology (HP:0011840)	1.77546660
89	Male pseudohermaphroditism (HP:0000037)	1.76835482
90	Methylmalonic aciduria (HP:0012120)	1.76348641
91	Exercise intolerance (HP:0003546)	1.76061345
92	Hypoplasia of the uterus (HP:0000013)	1.75847591
93	Erythroderma (HP:0001019)	1.72775790
94	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.71342563
95	Hypoplasia of the ulna (HP:0003022)	1.69646806
96	Type I transferrin isoform profile (HP:0003642)	1.69632904
97	Type 2 muscle fiber atrophy (HP:0003554)	1.69632364
98	Pendular nystagmus (HP:0012043)	1.67853859
99	Constricted visual fields (HP:0001133)	1.67519216
100	Parakeratosis (HP:0001036)	1.66610481

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.52918971
2	TLK1	2.92231741
3	KDR	2.89222949
4	MAP3K12	2.85717499
5	ADRBK2	2.51100343
6	MAP4K2	2.48643903
7	GRK1	2.44676503
8	ZAK	2.39091417
9	CDK19	2.35766998
10	FRK	2.20404276
11	TAOK3	2.16057364
12	WNK4	2.12641551
13	BCKDK	1.99249024
14	NUAK1	1.91845926
15	MAP4K1	1.87596489
16	ITK	1.66900444
17	MST4	1.63864119
18	GRK6	1.62325322
19	PASK	1.61435474
20	STK16	1.60521470
21	MYLK	1.50108360
22	SCYL2	1.48633076
23	TEC	1.45671492
24	FES	1.43245210
25	IKBKB	1.39704278
26	OXSR1	1.39028864
27	PINK1	1.36188145
28	VRK2	1.32437346
29	TIE1	1.30818554
30	WNK3	1.26531560
31	STK39	1.21016934
32	TESK2	1.19300442
33	BMPR2	1.19258259
34	SYK	1.17482450
35	BTK	1.17292110
36	INSRR	1.11770668
37	PIK3CA	1.04377203
38	PRKCQ	1.01666649
39	CSF1R	0.99180065
40	VRK1	0.99055557
41	GRK7	0.98481142
42	LIMK1	0.96830743
43	MUSK	0.95752758
44	DYRK2	0.92203985
45	KIT	0.91365659
46	LCK	0.85557491
47	BMPR1B	0.84943006
48	LYN	0.82652292
49	MAPK13	0.81237556
50	MAP2K2	0.79032789
51	RPS6KA5	0.75980328
52	CAMKK2	0.74701484
53	ADRBK1	0.73772244
54	OBSCN	0.72291703
55	IGF1R	0.71842884
56	NME1	0.68125086
57	TRIM28	0.62476849
58	DAPK3	0.62046939
59	PIK3CG	0.61318459
60	CSNK1G2	0.57660946
61	IKBKE	0.57397651
62	DAPK1	0.57108846
63	EIF2AK3	0.57007316
64	PRKACA	0.55706036
65	PIM1	0.55330127
66	PHKG1	0.55160878
67	PHKG2	0.55160878
68	EIF2AK1	0.53831976
69	GRK5	0.52433328
70	PRKCE	0.50171244
71	MAP2K6	0.49030238
72	PRKCA	0.48633126
73	FLT3	0.48213608
74	CSNK1G3	0.48192130
75	CAMKK1	0.48102699
76	MAP3K4	0.47910325
77	PRKCG	0.47119986
78	DAPK2	0.45941410
79	CSK	0.43366697
80	ERBB3	0.42913503
81	CSNK2A2	0.42293907
82	CAMK2A	0.40976716
83	CAMK1	0.39798693
84	PAK3	0.39544018
85	AURKB	0.39523881
86	CSNK2A1	0.37021484
87	ROCK1	0.36085842
88	PRKCD	0.35681329
89	JAK3	0.35619680
90	ILK	0.34503850
91	TRPM7	0.34352091
92	RPS6KA6	0.32349047
93	CSNK1G1	0.31467426
94	CSNK1A1	0.29436245
95	CAMK2D	0.28733707
96	MATK	0.28598051
97	ATR	0.27948643
98	ABL1	0.26490292
99	CHUK	0.25718762
100	FYN	0.25550415

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.21929479
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.97054965
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.21409255
4	Proteasome_Homo sapiens_hsa03050	3.15232104
5	Parkinsons disease_Homo sapiens_hsa05012	3.13155804
6	Asthma_Homo sapiens_hsa05310	2.72903191
7	Allograft rejection_Homo sapiens_hsa05330	2.70657356
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.65443826
9	Protein export_Homo sapiens_hsa03060	2.57203194
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.50165556
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.42422312
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.21026782
13	RNA polymerase_Homo sapiens_hsa03020	2.14228531
14	Alzheimers disease_Homo sapiens_hsa05010	2.12925853
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.01181182
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.98719531
17	Huntingtons disease_Homo sapiens_hsa05016	1.94826214
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.87866111
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.76979672
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.72729199
21	Homologous recombination_Homo sapiens_hsa03440	1.64880715
22	Phototransduction_Homo sapiens_hsa04744	1.61656638
23	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.54200328
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49309098
25	Caffeine metabolism_Homo sapiens_hsa00232	1.44058389
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.41638656
27	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.37393266
28	RNA degradation_Homo sapiens_hsa03018	1.30966954
29	Rheumatoid arthritis_Homo sapiens_hsa05323	1.30623484
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20184625
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.18430952
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08776561
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.01637749
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01313551
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.99147054
36	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.97745684
37	Tryptophan metabolism_Homo sapiens_hsa00380	0.95936084
38	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.95133437
39	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.94513910
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93457658
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90360777
42	Nucleotide excision repair_Homo sapiens_hsa03420	0.90016132
43	Peroxisome_Homo sapiens_hsa04146	0.89291795
44	One carbon pool by folate_Homo sapiens_hsa00670	0.87568634
45	Basal transcription factors_Homo sapiens_hsa03022	0.84787956
46	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.83878516
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83036751
48	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.83000400
49	Viral myocarditis_Homo sapiens_hsa05416	0.81091667
50	Purine metabolism_Homo sapiens_hsa00230	0.78029900
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77749636
52	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.77289442
53	Mismatch repair_Homo sapiens_hsa03430	0.77078379
54	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.76460643
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76267534
56	Olfactory transduction_Homo sapiens_hsa04740	0.75456778
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74805109
58	Retinol metabolism_Homo sapiens_hsa00830	0.73025952
59	Propanoate metabolism_Homo sapiens_hsa00640	0.70517258
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70196490
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66525696
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.65202531
63	Butanoate metabolism_Homo sapiens_hsa00650	0.63920844
64	Spliceosome_Homo sapiens_hsa03040	0.62862864
65	Nicotine addiction_Homo sapiens_hsa05033	0.62461548
66	DNA replication_Homo sapiens_hsa03030	0.59601770
67	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59390308
68	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.58959292
69	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.56980543
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.55563383
71	Metabolic pathways_Homo sapiens_hsa01100	0.54947031
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.54279416
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53226869
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52795431
75	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.52180822
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.51760681
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48757504
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.47778224
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.46721870
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44495555
81	Regulation of autophagy_Homo sapiens_hsa04140	0.41912007
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39872856
83	Morphine addiction_Homo sapiens_hsa05032	0.38974972
84	Base excision repair_Homo sapiens_hsa03410	0.36463799
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34859279
86	RNA transport_Homo sapiens_hsa03013	0.33724764
87	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32760431
88	Taste transduction_Homo sapiens_hsa04742	0.29064039
89	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.28894369
90	Sulfur metabolism_Homo sapiens_hsa00920	0.25895766
91	Tyrosine metabolism_Homo sapiens_hsa00350	0.22750548
92	Leishmaniasis_Homo sapiens_hsa05140	0.22631218
93	Salivary secretion_Homo sapiens_hsa04970	0.22465412
94	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.20312823
95	Measles_Homo sapiens_hsa05162	0.18882259
96	Glutathione metabolism_Homo sapiens_hsa00480	0.17930237
97	Herpes simplex infection_Homo sapiens_hsa05168	0.17211876
98	Malaria_Homo sapiens_hsa05144	0.17208748
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.16330682
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.15708880

RPL21P39

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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