RPL21P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.01689459
2ribosomal small subunit assembly (GO:0000028)6.85484450
3translational termination (GO:0006415)6.75995279
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.09879365
5cotranslational protein targeting to membrane (GO:0006613)6.01147006
6protein targeting to ER (GO:0045047)5.95366513
7ribosomal small subunit biogenesis (GO:0042274)5.90468724
8ATP synthesis coupled proton transport (GO:0015986)5.74068556
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.74068556
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.69340936
11translational elongation (GO:0006414)5.68929829
12protein localization to endoplasmic reticulum (GO:0070972)5.67173094
13maturation of SSU-rRNA (GO:0030490)5.62902032
14cellular protein complex disassembly (GO:0043624)5.04872695
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.00762040
16viral life cycle (GO:0019058)4.98001304
17ribosomal large subunit biogenesis (GO:0042273)4.95296343
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.84401423
19translational initiation (GO:0006413)4.54529223
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.51126002
21protein complex biogenesis (GO:0070271)4.14426914
22protein complex disassembly (GO:0043241)4.13137208
23mitochondrial respiratory chain complex I assembly (GO:0032981)4.12408994
24NADH dehydrogenase complex assembly (GO:0010257)4.12408994
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.12408994
26translation (GO:0006412)4.11135040
27DNA deamination (GO:0045006)4.10038474
28protein targeting to membrane (GO:0006612)4.09230447
29macromolecular complex disassembly (GO:0032984)3.93558162
30protein neddylation (GO:0045116)3.91817508
31behavioral response to nicotine (GO:0035095)3.87958236
32respiratory electron transport chain (GO:0022904)3.85415286
33electron transport chain (GO:0022900)3.83508454
34mitochondrial respiratory chain complex assembly (GO:0033108)3.79302091
35chaperone-mediated protein transport (GO:0072321)3.78521627
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.77906226
37positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.50862668
38water-soluble vitamin biosynthetic process (GO:0042364)3.49322030
39nuclear-transcribed mRNA catabolic process (GO:0000956)3.48416730
40response to xenobiotic stimulus (GO:0009410)3.42593029
41cellular component biogenesis (GO:0044085)3.30228260
42platelet dense granule organization (GO:0060155)3.30227959
43ATP biosynthetic process (GO:0006754)3.27734293
44mRNA catabolic process (GO:0006402)3.27424598
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.27319996
46GTP biosynthetic process (GO:0006183)3.26008054
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.25903853
48regulation of isotype switching to IgG isotypes (GO:0048302)3.19205246
49ribonucleoprotein complex biogenesis (GO:0022613)3.18784518
50hydrogen ion transmembrane transport (GO:1902600)3.16381129
51regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.12294035
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12006148
53regulation of immunoglobulin secretion (GO:0051023)3.11888653
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06774446
55RNA catabolic process (GO:0006401)3.03567052
56termination of RNA polymerase III transcription (GO:0006386)2.99607195
57transcription elongation from RNA polymerase III promoter (GO:0006385)2.99607195
58proton transport (GO:0015992)2.92365779
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91353016
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91353016
61ribonucleoside triphosphate biosynthetic process (GO:0009201)2.87487480
62indolalkylamine metabolic process (GO:0006586)2.84544650
63hydrogen transport (GO:0006818)2.84328513
64kynurenine metabolic process (GO:0070189)2.83636075
65indole-containing compound catabolic process (GO:0042436)2.79381889
66indolalkylamine catabolic process (GO:0046218)2.79381889
67tryptophan catabolic process (GO:0006569)2.79381889
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79080335
69substrate-independent telencephalic tangential migration (GO:0021826)2.78159691
70substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.78159691
71regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.77700553
72respiratory chain complex IV assembly (GO:0008535)2.73093165
73establishment of protein localization to membrane (GO:0090150)2.72569549
74nonmotile primary cilium assembly (GO:0035058)2.72325865
75detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70447918
76pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68857794
77cell proliferation in forebrain (GO:0021846)2.68382297
78somite development (GO:0061053)2.67517638
79protein targeting (GO:0006605)2.64914022
80UTP biosynthetic process (GO:0006228)2.64031130
81axoneme assembly (GO:0035082)2.63798466
82tongue development (GO:0043586)2.63304560
83activated T cell proliferation (GO:0050798)2.62787041
84GPI anchor metabolic process (GO:0006505)2.62509264
85response to pheromone (GO:0019236)2.59600372
86negative regulation of T cell differentiation in thymus (GO:0033085)2.58102917
87parturition (GO:0007567)2.56466170
88negative regulation of mast cell activation (GO:0033004)2.54872978
89base-excision repair, AP site formation (GO:0006285)2.52142439
90regulation of regulatory T cell differentiation (GO:0045589)2.51820114
91rRNA metabolic process (GO:0016072)2.51143703
92L-fucose catabolic process (GO:0042355)2.50218887
93fucose catabolic process (GO:0019317)2.50218887
94L-fucose metabolic process (GO:0042354)2.50218887
95cytidine metabolic process (GO:0046087)2.48849348
96cytidine catabolic process (GO:0006216)2.48849348
97cytidine deamination (GO:0009972)2.48849348
98rRNA processing (GO:0006364)2.47064983
99preassembly of GPI anchor in ER membrane (GO:0016254)2.46937973
100UTP metabolic process (GO:0046051)2.46686812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01877842
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.81947763
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.81837486
4VDR_22108803_ChIP-Seq_LS180_Human3.05138970
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00059380
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.87427524
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.85821430
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28822446
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.26435704
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06743252
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.05501248
12VDR_23849224_ChIP-Seq_CD4+_Human1.95466436
13ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89272237
14TP53_22573176_ChIP-Seq_HFKS_Human1.88920385
15ZNF274_21170338_ChIP-Seq_K562_Hela1.86402600
16ELK1_19687146_ChIP-ChIP_HELA_Human1.85862891
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.81542888
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78886302
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76704982
20MYC_18940864_ChIP-ChIP_HL60_Human1.71173374
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67183885
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66184433
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.62774091
24FUS_26573619_Chip-Seq_HEK293_Human1.61986910
25IRF1_19129219_ChIP-ChIP_H3396_Human1.60773262
26FOXP3_21729870_ChIP-Seq_TREG_Human1.59752290
27EWS_26573619_Chip-Seq_HEK293_Human1.58949821
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50806600
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46023864
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42580328
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41515684
32P300_19829295_ChIP-Seq_ESCs_Human1.37973232
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36848714
34FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32825435
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.32825435
36TTF2_22483619_ChIP-Seq_HELA_Human1.32807317
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32653822
38SOX2_19829295_ChIP-Seq_ESCs_Human1.27369211
39NANOG_19829295_ChIP-Seq_ESCs_Human1.27369211
40TAF2_19829295_ChIP-Seq_ESCs_Human1.26849891
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25681963
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23639043
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.23567730
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22635183
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21473140
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19743226
47NCOR_22424771_ChIP-Seq_293T_Human1.19420588
48ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17835125
49NANOG_20526341_ChIP-Seq_ESCs_Human1.17259167
50RNF2_27304074_Chip-Seq_NSC_Mouse1.17199047
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15971952
52CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14696418
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14468960
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14255448
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.14171812
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.14020649
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.14014914
58AR_20517297_ChIP-Seq_VCAP_Human1.13351164
59TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11902734
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11549198
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.11497455
62ER_23166858_ChIP-Seq_MCF-7_Human1.11037978
63HOXB7_26014856_ChIP-Seq_BT474_Human1.10663416
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10391605
65ERA_21632823_ChIP-Seq_H3396_Human1.09249399
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07645677
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06171131
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06044920
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.06017278
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.06008256
71IGF1R_20145208_ChIP-Seq_DFB_Human1.05382188
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.05046628
73CBP_20019798_ChIP-Seq_JUKART_Human1.04254569
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04254569
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02715901
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02600966
77P53_21459846_ChIP-Seq_SAOS-2_Human1.02198478
78FOXH1_21741376_ChIP-Seq_EPCs_Human1.02134967
79GATA3_26560356_Chip-Seq_TH2_Human1.01946914
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01250638
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01100747
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00965829
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99681579
84MYC_19829295_ChIP-Seq_ESCs_Human0.99335665
85ERG_20517297_ChIP-Seq_VCAP_Human0.98790145
86REST_21632747_ChIP-Seq_MESCs_Mouse0.98486988
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96339005
88SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96285677
89GBX2_23144817_ChIP-Seq_PC3_Human0.95486675
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95404007
91EED_16625203_ChIP-ChIP_MESCs_Mouse0.93953274
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92625859
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90995756
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90593269
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88914135
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87280555
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87108144
98MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86784347
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86041480
100YY1_21170310_ChIP-Seq_MESCs_Mouse0.85940507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.84123033
2MP0006292_abnormal_olfactory_placode4.16067140
3MP0002163_abnormal_gland_morphology2.80436782
4MP0004147_increased_porphyrin_level2.36868818
5MP0001835_abnormal_antigen_presentation2.31427778
6MP0008877_abnormal_DNA_methylation2.28631678
7MP0004142_abnormal_muscle_tone2.19524846
8MP0005671_abnormal_response_to2.12093517
9MP0003646_muscle_fatigue1.92736763
10MP0002876_abnormal_thyroid_physiology1.92719958
11MP0003878_abnormal_ear_physiology1.88235998
12MP0005377_hearing/vestibular/ear_phenot1.88235998
13MP0000372_irregular_coat_pigmentation1.86531782
14MP0008875_abnormal_xenobiotic_pharmacok1.85254229
15MP0005379_endocrine/exocrine_gland_phen1.80326719
16MP0001348_abnormal_lacrimal_gland1.78806881
17MP0002837_dystrophic_cardiac_calcinosis1.78216079
18MP0001873_stomach_inflammation1.75455288
19MP0002102_abnormal_ear_morphology1.73376315
20MP0005551_abnormal_eye_electrophysiolog1.64387051
21MP0002653_abnormal_ependyma_morphology1.63494763
22MP0003787_abnormal_imprinting1.61991977
23MP0008872_abnormal_physiological_respon1.59340655
24MP0002095_abnormal_skin_pigmentation1.56606311
25MP0001905_abnormal_dopamine_level1.52281369
26MP0001293_anophthalmia1.51576111
27MP0001968_abnormal_touch/_nociception1.49661368
28MP0001485_abnormal_pinna_reflex1.49622302
29MP0002938_white_spotting1.48266221
30MP0003011_delayed_dark_adaptation1.48218008
31MP0003186_abnormal_redox_activity1.43899780
32MP0008789_abnormal_olfactory_epithelium1.42772261
33MP0006072_abnormal_retinal_apoptosis1.42714454
34MP0002736_abnormal_nociception_after1.41383011
35MP0005646_abnormal_pituitary_gland1.40831876
36MP0002272_abnormal_nervous_system1.39788948
37MP0004885_abnormal_endolymph1.37773424
38MP0004145_abnormal_muscle_electrophysio1.37660786
39MP0001986_abnormal_taste_sensitivity1.33338299
40MP0003880_abnormal_central_pattern1.33302674
41MP0003136_yellow_coat_color1.30006369
42MP0000049_abnormal_middle_ear1.28928333
43MP0002277_abnormal_respiratory_mucosa1.28866356
44MP0005408_hypopigmentation1.25105495
45MP0005174_abnormal_tail_pigmentation1.23898159
46MP0005389_reproductive_system_phenotype1.18586987
47MP0001529_abnormal_vocalization1.18480659
48MP0000631_abnormal_neuroendocrine_gland1.18037248
49MP0005645_abnormal_hypothalamus_physiol1.17914784
50MP0005075_abnormal_melanosome_morpholog1.16861971
51MP0000685_abnormal_immune_system1.14850355
52MP0003122_maternal_imprinting1.13911414
53MP0002234_abnormal_pharynx_morphology1.12398779
54MP0003806_abnormal_nucleotide_metabolis1.10641089
55MP0005084_abnormal_gallbladder_morpholo1.05958496
56MP0005387_immune_system_phenotype1.05715148
57MP0001790_abnormal_immune_system1.05715148
58MP0002148_abnormal_hypersensitivity_rea1.03444125
59MP0001919_abnormal_reproductive_system1.02301606
60MP0005394_taste/olfaction_phenotype1.01619055
61MP0005499_abnormal_olfactory_system1.01619055
62MP0001440_abnormal_grooming_behavior1.01321251
63MP0009745_abnormal_behavioral_response1.00810729
64MP0009764_decreased_sensitivity_to1.00593881
65MP0006276_abnormal_autonomic_nervous0.99972153
66MP0002638_abnormal_pupillary_reflex0.98251706
67MP0001800_abnormal_humoral_immune0.97638404
68MP0006036_abnormal_mitochondrial_physio0.97605552
69MP0001486_abnormal_startle_reflex0.96653779
70MP0005423_abnormal_somatic_nervous0.94953699
71MP0002160_abnormal_reproductive_system0.94527911
72MP0005253_abnormal_eye_physiology0.93395201
73MP0005195_abnormal_posterior_eye0.92039689
74MP0009785_altered_susceptibility_to0.90150693
75MP0003567_abnormal_fetal_cardiomyocyte0.89109168
76MP0001970_abnormal_pain_threshold0.88897128
77MP0002557_abnormal_social/conspecific_i0.87746475
78MP0001984_abnormal_olfaction0.85849870
79MP0005636_abnormal_mineral_homeostasis0.84674757
80MP0003938_abnormal_ear_development0.84457713
81MP0000026_abnormal_inner_ear0.84341773
82MP0002822_catalepsy0.81992888
83MP0001502_abnormal_circadian_rhythm0.80673278
84MP0006082_CNS_inflammation0.79995070
85MP0002090_abnormal_vision0.79628417
86MP0001663_abnormal_digestive_system0.78138972
87MP0002572_abnormal_emotion/affect_behav0.77299834
88MP0001963_abnormal_hearing_physiology0.77036783
89MP0002752_abnormal_somatic_nervous0.76797740
90MP0001765_abnormal_ion_homeostasis0.75841141
91MP0004742_abnormal_vestibular_system0.75046001
92MP0004133_heterotaxia0.72247281
93MP0002184_abnormal_innervation0.71866162
94MP0009046_muscle_twitch0.71856577
95MP0009333_abnormal_splenocyte_physiolog0.70652365
96MP0001188_hyperpigmentation0.67924837
97MP0003195_calcinosis0.66668952
98MP0004019_abnormal_vitamin_homeostasis0.66574235
99MP0005000_abnormal_immune_tolerance0.66501540
100MP0002734_abnormal_mechanical_nocicepti0.66444620

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.96233148
2Reticulocytopenia (HP:0001896)4.80256092
3Acute encephalopathy (HP:0006846)4.40746881
4Abnormal mitochondria in muscle tissue (HP:0008316)4.29458178
5Progressive macrocephaly (HP:0004481)4.08879969
6Mitochondrial inheritance (HP:0001427)4.04727837
7Hepatocellular necrosis (HP:0001404)3.77249803
8Abnormality of cells of the erythroid lineage (HP:0012130)3.70951290
9Molar tooth sign on MRI (HP:0002419)3.65542622
10Abnormality of midbrain morphology (HP:0002418)3.65542622
11Septo-optic dysplasia (HP:0100842)3.58543067
12Increased CSF lactate (HP:0002490)3.52988646
13Macrocytic anemia (HP:0001972)3.49133251
14Hepatic necrosis (HP:0002605)3.24973012
15Pancreatic cysts (HP:0001737)3.17210779
16Congenital stationary night blindness (HP:0007642)3.12296479
17Pancreatic fibrosis (HP:0100732)3.08074879
18Cerebral edema (HP:0002181)3.04768792
19Increased hepatocellular lipid droplets (HP:0006565)3.03600346
20Lipid accumulation in hepatocytes (HP:0006561)3.02171687
213-Methylglutaconic aciduria (HP:0003535)2.98661667
22Pendular nystagmus (HP:0012043)2.89243479
23Aplasia/Hypoplasia of the spleen (HP:0010451)2.79979559
24Stenosis of the external auditory canal (HP:0000402)2.79809472
25Nephronophthisis (HP:0000090)2.72163324
26Type II lissencephaly (HP:0007260)2.70551077
27Congenital, generalized hypertrichosis (HP:0004540)2.70182825
28Optic disc pallor (HP:0000543)2.69860426
29Asplenia (HP:0001746)2.67964561
30Abnormal number of erythroid precursors (HP:0012131)2.66485487
31Stomatitis (HP:0010280)2.64106722
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63704599
33IgG deficiency (HP:0004315)2.58249155
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.57760744
35Pallor (HP:0000980)2.57744507
36Hypoplasia of the ulna (HP:0003022)2.55295540
37Medial flaring of the eyebrow (HP:0010747)2.55281689
38Leukodystrophy (HP:0002415)2.53391992
39Abnormal rod and cone electroretinograms (HP:0008323)2.52157063
40True hermaphroditism (HP:0010459)2.49661457
41Renal Fanconi syndrome (HP:0001994)2.38804807
42Hyperglycinemia (HP:0002154)2.28453022
43Exertional dyspnea (HP:0002875)2.26534574
44Abolished electroretinogram (ERG) (HP:0000550)2.26082035
45Optic nerve hypoplasia (HP:0000609)2.26078207
46Lethargy (HP:0001254)2.24315456
47Increased intramyocellular lipid droplets (HP:0012240)2.23099106
48Increased IgM level (HP:0003496)2.22873300
49Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.22623436
50Abnormality of the renal medulla (HP:0100957)2.21334592
51Increased serum lactate (HP:0002151)2.19208724
52Rib fusion (HP:0000902)2.14924633
53Aplasia/Hypoplasia of the ulna (HP:0006495)2.14905641
54Sclerocornea (HP:0000647)2.13191789
55Absent thumb (HP:0009777)2.09571585
56Absent septum pellucidum (HP:0001331)2.09511980
57Abnormality of the renal cortex (HP:0011035)2.05769239
58Forearm undergrowth (HP:0009821)2.03107598
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.02799543
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01447698
61Cerebellar dysplasia (HP:0007033)2.01271845
62Abnormality of renal resorption (HP:0011038)1.99624527
63Hypoplasia of the radius (HP:0002984)1.98996338
64Methylmalonic acidemia (HP:0002912)1.96314442
65Increased muscle lipid content (HP:0009058)1.94139938
66Porencephaly (HP:0002132)1.92954973
67Abnormality of the prostate (HP:0008775)1.91339688
68Aplastic anemia (HP:0001915)1.91150747
69Lactic acidosis (HP:0003128)1.90733354
70Cystic liver disease (HP:0006706)1.88287574
71Respiratory failure (HP:0002878)1.87910997
72Abnormality of the phalanges of the 5th finger (HP:0004213)1.87258175
73Renal cortical cysts (HP:0000803)1.85431404
74Increased corneal curvature (HP:0100692)1.85283945
75Keratoconus (HP:0000563)1.85283945
76Abnormal ciliary motility (HP:0012262)1.81770415
77Abnormal respiratory motile cilium physiology (HP:0012261)1.79429003
78Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77570667
79Decreased central vision (HP:0007663)1.77403468
80Gait imbalance (HP:0002141)1.76707759
81Congenital primary aphakia (HP:0007707)1.76583268
82Abnormal drinking behavior (HP:0030082)1.75746422
83Polydipsia (HP:0001959)1.75746422
84Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.75038225
85Exercise intolerance (HP:0003546)1.73327356
86Anencephaly (HP:0002323)1.72216242
87Tachypnea (HP:0002789)1.71810763
88Abnormal respiratory motile cilium morphology (HP:0005938)1.71255099
89Abnormal respiratory epithelium morphology (HP:0012253)1.71255099
90Maternal diabetes (HP:0009800)1.70215015
91Hypoalbuminemia (HP:0003073)1.68861445
92Abnormal albumin level (HP:0012116)1.68861445
93Triphalangeal thumb (HP:0001199)1.68215281
94Abnormality of the pons (HP:0007361)1.67963724
95Attenuation of retinal blood vessels (HP:0007843)1.67741668
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66332206
97Cleft eyelid (HP:0000625)1.66187848
98Testicular atrophy (HP:0000029)1.65535829
99Growth hormone deficiency (HP:0000824)1.63563198
100Type 2 muscle fiber atrophy (HP:0003554)1.62913020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.46483108
2WNK42.72265924
3ADRBK22.60197074
4BCKDK2.53732718
5TIE12.46928397
6NUAK12.41445155
7CDK192.38284306
8ZAK2.30541832
9MAP3K122.22678001
10GRK12.21930380
11STK162.01693212
12TLK11.96077242
13MAP4K11.89741726
14DYRK21.80062750
15FRK1.68240529
16MAP4K21.66702633
17PINK11.57787856
18NME21.43620865
19MST41.37401519
20BMPR1B1.37024412
21TAOK31.35053833
22FES1.34690928
23MAP2K71.34037287
24OXSR11.31824651
25TEC1.31742949
26STK391.28486284
27MYLK1.26008102
28VRK21.23189113
29MAP3K41.22764757
30NME11.21430869
31NEK11.20621805
32TAF11.17290363
33BMPR21.16634968
34IKBKB1.15740790
35WNK11.12298449
36PNCK1.10406800
37LRRK21.09482716
38DAPK31.08006926
39EIF2AK11.07591430
40PIK3CA1.01047872
41INSRR0.98737484
42PRKCG0.97189007
43TYRO30.95773537
44PRKCQ0.91740925
45VRK10.89944368
46KIT0.88168043
47WNK30.87613447
48PAK30.86692665
49EPHA40.85345184
50ITK0.85118909
51TSSK60.83257917
52CAMK10.80530615
53ILK0.79589611
54ADRBK10.74612460
55RPS6KA60.72255797
56NTRK20.69586341
57DAPK20.68385193
58PASK0.68332450
59RPS6KA50.68164202
60CSNK2A20.64900514
61OBSCN0.64872541
62PRKACA0.61568920
63SIK20.61461805
64BTK0.61253094
65MAPK130.61163362
66MUSK0.60016714
67DAPK10.56903665
68ABL20.55998279
69JAK30.53819799
70MARK30.52752393
71PLK40.52327801
72RPS6KL10.52201381
73RPS6KC10.52201381
74CAMKK20.51447624
75PRKCE0.50927872
76PKN10.50804624
77PRKCA0.50072108
78LCK0.50010679
79LYN0.49922114
80IGF1R0.49581628
81PRKCD0.48741594
82CAMK2A0.47778971
83CSNK1A10.47328395
84CSNK2A10.45582005
85CASK0.44782500
86TNK20.43968327
87AURKB0.43824620
88MKNK10.43430501
89CSNK1G20.42957453
90MAP2K60.41022839
91AURKA0.40967839
92PIM10.40898988
93CAMK2D0.39426767
94SYK0.39324264
95CDC70.39156381
96ATR0.38661459
97TNIK0.38473628
98CSNK1E0.38377047
99PIK3CG0.38358063
100TRIM280.36558026

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.29658106
2Oxidative phosphorylation_Homo sapiens_hsa001903.88410534
3Asthma_Homo sapiens_hsa053103.80799283
4Allograft rejection_Homo sapiens_hsa053303.10136399
5Parkinsons disease_Homo sapiens_hsa050123.05276415
6Autoimmune thyroid disease_Homo sapiens_hsa053202.95146054
7Protein export_Homo sapiens_hsa030602.76727820
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.66538736
9Graft-versus-host disease_Homo sapiens_hsa053322.45602424
10Proteasome_Homo sapiens_hsa030502.41750115
11Type I diabetes mellitus_Homo sapiens_hsa049402.27125298
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26879525
13Alzheimers disease_Homo sapiens_hsa050102.16590091
14Huntingtons disease_Homo sapiens_hsa050162.04909295
15Cardiac muscle contraction_Homo sapiens_hsa042601.92976565
16RNA polymerase_Homo sapiens_hsa030201.89527087
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.89048918
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59841325
19Linoleic acid metabolism_Homo sapiens_hsa005911.54727326
20Phototransduction_Homo sapiens_hsa047441.43258195
21Homologous recombination_Homo sapiens_hsa034401.39342156
22Sulfur relay system_Homo sapiens_hsa041221.38673909
23Rheumatoid arthritis_Homo sapiens_hsa053231.32341250
24One carbon pool by folate_Homo sapiens_hsa006701.32321915
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31634769
26Basal transcription factors_Homo sapiens_hsa030221.31266658
27RNA degradation_Homo sapiens_hsa030181.23808877
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21336844
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17920451
30Primary immunodeficiency_Homo sapiens_hsa053401.17906945
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15665969
32Caffeine metabolism_Homo sapiens_hsa002321.13765232
33Antigen processing and presentation_Homo sapiens_hsa046121.11434997
34Tryptophan metabolism_Homo sapiens_hsa003801.08013820
35Collecting duct acid secretion_Homo sapiens_hsa049661.05443082
36Sulfur metabolism_Homo sapiens_hsa009201.02790717
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02193413
38Pyrimidine metabolism_Homo sapiens_hsa002400.94953515
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94674608
40Arachidonic acid metabolism_Homo sapiens_hsa005900.84943226
41Nucleotide excision repair_Homo sapiens_hsa034200.78135212
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77928498
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77078811
44Nitrogen metabolism_Homo sapiens_hsa009100.76806757
45Fanconi anemia pathway_Homo sapiens_hsa034600.76482576
46Chemical carcinogenesis_Homo sapiens_hsa052040.75679195
47Viral myocarditis_Homo sapiens_hsa054160.74462111
48Hematopoietic cell lineage_Homo sapiens_hsa046400.73497912
49Nicotine addiction_Homo sapiens_hsa050330.71636878
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71346982
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.69709778
52Butanoate metabolism_Homo sapiens_hsa006500.69049653
53Retinol metabolism_Homo sapiens_hsa008300.68726063
54Regulation of autophagy_Homo sapiens_hsa041400.65833546
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64819143
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63717316
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.62174963
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61939012
59Staphylococcus aureus infection_Homo sapiens_hsa051500.60742675
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.59681654
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58640706
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58230805
63RNA transport_Homo sapiens_hsa030130.58160278
64Purine metabolism_Homo sapiens_hsa002300.58117787
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57542798
66Olfactory transduction_Homo sapiens_hsa047400.56879900
67Propanoate metabolism_Homo sapiens_hsa006400.56431608
68Ether lipid metabolism_Homo sapiens_hsa005650.55839546
69Fat digestion and absorption_Homo sapiens_hsa049750.55488247
70Metabolic pathways_Homo sapiens_hsa011000.52419748
71Vitamin digestion and absorption_Homo sapiens_hsa049770.50194598
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49585541
73Peroxisome_Homo sapiens_hsa041460.49500992
74Mismatch repair_Homo sapiens_hsa034300.49034170
75Fatty acid biosynthesis_Homo sapiens_hsa000610.48933609
76Systemic lupus erythematosus_Homo sapiens_hsa053220.48698720
77Steroid biosynthesis_Homo sapiens_hsa001000.48634546
78Morphine addiction_Homo sapiens_hsa050320.46986632
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46771647
80Selenocompound metabolism_Homo sapiens_hsa004500.43872296
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42959468
82Taste transduction_Homo sapiens_hsa047420.42567655
83Fatty acid degradation_Homo sapiens_hsa000710.36662645
84Glutathione metabolism_Homo sapiens_hsa004800.35913526
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34951761
86Spliceosome_Homo sapiens_hsa030400.34353298
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.33866946
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33269178
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30749570
90T cell receptor signaling pathway_Homo sapiens_hsa046600.28065599
91Serotonergic synapse_Homo sapiens_hsa047260.25876255
92Folate biosynthesis_Homo sapiens_hsa007900.24794874
93DNA replication_Homo sapiens_hsa030300.24695247
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24686484
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24223757
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24114367
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23472258
98Mineral absorption_Homo sapiens_hsa049780.22964243
99Insulin secretion_Homo sapiens_hsa049110.22910198
100Salivary secretion_Homo sapiens_hsa049700.20334893

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