ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.89685475
2	viral transcription (GO:0019083)	7.03291978
3	translational termination (GO:0006415)	6.78915795
4	ribosomal small subunit biogenesis (GO:0042274)	6.18295644
5	maturation of SSU-rRNA (GO:0030490)	6.02868051
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.80635742
7	cotranslational protein targeting to membrane (GO:0006613)	5.72685418
8	protein targeting to ER (GO:0045047)	5.67958557
9	translational elongation (GO:0006414)	5.61279624
10	behavioral response to nicotine (GO:0035095)	5.54885370
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.51067334
12	protein localization to endoplasmic reticulum (GO:0070972)	5.30390292
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.13387263
14	ATP synthesis coupled proton transport (GO:0015986)	5.13387263
15	viral life cycle (GO:0019058)	5.08139935
16	cellular protein complex disassembly (GO:0043624)	5.06937206
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.91432702
18	nonmotile primary cilium assembly (GO:0035058)	4.72490762
19	chaperone-mediated protein transport (GO:0072321)	4.53108146
20	translational initiation (GO:0006413)	4.41540255
21	protein complex disassembly (GO:0043241)	4.24496271
22	macromolecular complex disassembly (GO:0032984)	4.10279071
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.07204114
24	water-soluble vitamin biosynthetic process (GO:0042364)	4.05641457
25	GTP biosynthetic process (GO:0006183)	4.02127508
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.95857516
27	head development (GO:0060322)	3.81972220
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.77475550
29	protein targeting to membrane (GO:0006612)	3.72712317
30	protein complex biogenesis (GO:0070271)	3.60969087
31	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.58602523
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.55881627
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.55881627
34	NADH dehydrogenase complex assembly (GO:0010257)	3.55881627
35	tongue development (GO:0043586)	3.51212518
36	translation (GO:0006412)	3.50624968
37	mRNA catabolic process (GO:0006402)	3.41248036
38	cell proliferation in forebrain (GO:0021846)	3.41226608
39	UTP biosynthetic process (GO:0006228)	3.41063901
40	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.35384155
41	negative regulation of telomere maintenance (GO:0032205)	3.35148940
42	ribosomal large subunit biogenesis (GO:0042273)	3.31334156
43	regulation of cilium movement (GO:0003352)	3.27775792
44	protein neddylation (GO:0045116)	3.16458532
45	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.14957553
46	pyrimidine nucleobase catabolic process (GO:0006208)	3.12780855
47	mitochondrial respiratory chain complex assembly (GO:0033108)	3.11665239
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.10186298
49	endoderm formation (GO:0001706)	3.10000559
50	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.09140717
51	substrate-independent telencephalic tangential migration (GO:0021826)	3.09140717
52	UTP metabolic process (GO:0046051)	3.08576707
53	epithelial cilium movement (GO:0003351)	3.02735311
54	RNA catabolic process (GO:0006401)	3.02447873
55	dendritic spine morphogenesis (GO:0060997)	2.99526352
56	cellular component biogenesis (GO:0044085)	2.98498219
57	electron transport chain (GO:0022900)	2.97308954
58	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.96362784
59	protein K6-linked ubiquitination (GO:0085020)	2.96196771
60	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.95844095
61	respiratory electron transport chain (GO:0022904)	2.95620969
62	regulation of immunoglobulin secretion (GO:0051023)	2.94525657
63	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.92184663
64	peptidyl-histidine modification (GO:0018202)	2.90115955
65	ribonucleoprotein complex biogenesis (GO:0022613)	2.89673044
66	positive regulation of respiratory burst (GO:0060267)	2.89113745
67	rRNA catabolic process (GO:0016075)	2.89044129
68	somite development (GO:0061053)	2.88407125
69	kidney morphogenesis (GO:0060993)	2.88075910
70	CTP metabolic process (GO:0046036)	2.87751958
71	CTP biosynthetic process (GO:0006241)	2.87751958
72	ATP biosynthetic process (GO:0006754)	2.87430199
73	spinal cord association neuron differentiation (GO:0021527)	2.85965444
74	positive regulation of gastrulation (GO:2000543)	2.83445906
75	hydrogen ion transmembrane transport (GO:1902600)	2.81750564
76	ncRNA 3-end processing (GO:0043628)	2.80218872
77	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.78051234
78	dentate gyrus development (GO:0021542)	2.76828404
79	auditory receptor cell differentiation (GO:0042491)	2.75890589
80	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.75400562
81	proton transport (GO:0015992)	2.73990297
82	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.73116029
83	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.73116029
84	intracellular protein transmembrane import (GO:0044743)	2.69412314
85	hydrogen transport (GO:0006818)	2.66290397
86	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.64947350
87	thalamus development (GO:0021794)	2.62753441
88	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.62440196
89	DNA deamination (GO:0045006)	2.59755206
90	cardiovascular system development (GO:0072358)	2.57066032
91	urogenital system development (GO:0001655)	2.56723068
92	regulation of isotype switching to IgG isotypes (GO:0048302)	2.56600872
93	photoreceptor cell maintenance (GO:0045494)	2.54620432
94	nucleobase catabolic process (GO:0046113)	2.54310837
95	cilium movement (GO:0003341)	2.54150201
96	piRNA metabolic process (GO:0034587)	2.54109762
97	limb development (GO:0060173)	2.53543138
98	appendage development (GO:0048736)	2.53543138
99	negative regulation of appetite (GO:0032099)	2.53486921
100	negative regulation of response to food (GO:0032096)	2.53486921

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.13709633
2	VDR_22108803_ChIP-Seq_LS180_Human	3.13969518
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.91402420
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.76865555
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.54583182
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53769312
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.46757621
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.36498233
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.29723082
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.27721911
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.15739572
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.14512642
13	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.09254500
14	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.08787834
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.08487917
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.02350373
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.90503836
18	GBX2_23144817_ChIP-Seq_PC3_Human	1.89747989
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.88588932
20	EWS_26573619_Chip-Seq_HEK293_Human	1.86269786
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.81944928
22	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.74377430
23	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.68918478
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.62353178
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.62238346
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.62107231
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.61839243
28	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.57708704
29	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.57628757
30	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.56569600
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55479540
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.54989119
33	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.53756878
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.52781471
35	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46082091
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.45725558
37	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.43892542
38	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.43883342
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41941854
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.35704823
41	P300_19829295_ChIP-Seq_ESCs_Human	1.31963082
42	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.30609537
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.29838491
44	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.29436920
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.28996512
46	FUS_26573619_Chip-Seq_HEK293_Human	1.28667580
47	ERA_21632823_ChIP-Seq_H3396_Human	1.25524113
48	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.25316089
49	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.24801325
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.23034936
51	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.22158231
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.22082578
53	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.20229855
54	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.20229855
55	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.19354299
56	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.19089584
57	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17915034
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16925917
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16925917
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15697235
61	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.15646112
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14515542
63	NCOR_22424771_ChIP-Seq_293T_Human	1.14460863
64	FOXP3_21729870_ChIP-Seq_TREG_Human	1.12600273
65	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.11971506
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11757833
67	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11557445
68	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11303763
69	AR_20517297_ChIP-Seq_VCAP_Human	1.09132284
70	TAF2_19829295_ChIP-Seq_ESCs_Human	1.09060777
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08320743
72	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.08151646
73	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.07148139
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.03907087
75	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03220229
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03220229
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.01604249
78	ER_23166858_ChIP-Seq_MCF-7_Human	1.01196974
79	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.00685925
80	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.98841332
81	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.96645152
82	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96226268
83	ELK1_19687146_ChIP-ChIP_HELA_Human	0.95391877
84	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.94393606
85	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.94327546
86	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.93141849
87	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93141849
88	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.92492251
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92057998
90	P53_21459846_ChIP-Seq_SAOS-2_Human	0.91453182
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.91327081
92	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.91011719
93	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.90990867
94	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.90909700
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.90808341
96	TAF15_26573619_Chip-Seq_HEK293_Human	0.88647728
97	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88553678
98	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.88335200
99	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.88303675
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.88303675

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.34885728
2	MP0006292_abnormal_olfactory_placode	4.99232382
3	MP0008877_abnormal_DNA_methylation	2.83276101
4	MP0003787_abnormal_imprinting	2.72372739
5	MP0000566_synostosis	2.71861517
6	MP0008789_abnormal_olfactory_epithelium	2.54008037
7	MP0002653_abnormal_ependyma_morphology	2.41414367
8	MP0003283_abnormal_digestive_organ	2.41081797
9	MP0002102_abnormal_ear_morphology	2.25913357
10	MP0003136_yellow_coat_color	2.23214437
11	MP0006072_abnormal_retinal_apoptosis	2.09394878
12	MP0004142_abnormal_muscle_tone	2.09003568
13	MP0005394_taste/olfaction_phenotype	2.08469213
14	MP0005499_abnormal_olfactory_system	2.08469213
15	MP0004885_abnormal_endolymph	2.06154162
16	MP0002938_white_spotting	1.91195737
17	MP0003122_maternal_imprinting	1.89345812
18	MP0001485_abnormal_pinna_reflex	1.88424208
19	MP0006276_abnormal_autonomic_nervous	1.81110972
20	MP0003646_muscle_fatigue	1.80610767
21	MP0003880_abnormal_central_pattern	1.79515412
22	MP0001293_anophthalmia	1.75453880
23	MP0000778_abnormal_nervous_system	1.73679526
24	MP0004742_abnormal_vestibular_system	1.73320383
25	MP0002234_abnormal_pharynx_morphology	1.65870069
26	MP0002163_abnormal_gland_morphology	1.64494550
27	MP0005551_abnormal_eye_electrophysiolog	1.64051305
28	MP0000049_abnormal_middle_ear	1.63441604
29	MP0001984_abnormal_olfaction	1.63294279
30	MP0002277_abnormal_respiratory_mucosa	1.63208481
31	MP0002837_dystrophic_cardiac_calcinosis	1.54359440
32	MP0002272_abnormal_nervous_system	1.53206030
33	MP0004145_abnormal_muscle_electrophysio	1.52976027
34	MP0003121_genomic_imprinting	1.51740699
35	MP0003195_calcinosis	1.51315906
36	MP0001986_abnormal_taste_sensitivity	1.48564612
37	MP0005646_abnormal_pituitary_gland	1.47820614
38	MP0001348_abnormal_lacrimal_gland	1.47462688
39	MP0001968_abnormal_touch/_nociception	1.44558206
40	MP0002638_abnormal_pupillary_reflex	1.41157140
41	MP0000631_abnormal_neuroendocrine_gland	1.34080008
42	MP0008872_abnormal_physiological_respon	1.32644464
43	MP0008875_abnormal_xenobiotic_pharmacok	1.32334640
44	MP0002095_abnormal_skin_pigmentation	1.30914539
45	MP0002876_abnormal_thyroid_physiology	1.29681632
46	MP0001529_abnormal_vocalization	1.25486098
47	MP0002138_abnormal_hepatobiliary_system	1.22335592
48	MP0003938_abnormal_ear_development	1.22235912
49	MP0004133_heterotaxia	1.22024130
50	MP0005195_abnormal_posterior_eye	1.21990823
51	MP0009745_abnormal_behavioral_response	1.18779128
52	MP0000026_abnormal_inner_ear	1.17845090
53	MP0003890_abnormal_embryonic-extraembry	1.17405909
54	MP0002557_abnormal_social/conspecific_i	1.14598921
55	MP0002736_abnormal_nociception_after	1.14519419
56	MP0008775_abnormal_heart_ventricle	1.13253398
57	MP0005253_abnormal_eye_physiology	1.12629776
58	MP0010030_abnormal_orbit_morphology	1.11444630
59	MP0003123_paternal_imprinting	1.07236510
60	MP0001970_abnormal_pain_threshold	1.06912737
61	MP0002735_abnormal_chemical_nociception	1.04014956
62	MP0001963_abnormal_hearing_physiology	1.01676482
63	MP0003567_abnormal_fetal_cardiomyocyte	1.01528372
64	MP0003119_abnormal_digestive_system	1.00505393
65	MP0002733_abnormal_thermal_nociception	1.00291296
66	MP0005075_abnormal_melanosome_morpholog	0.98169539
67	MP0002752_abnormal_somatic_nervous	0.96330060
68	MP0000955_abnormal_spinal_cord	0.96076989
69	MP0000427_abnormal_hair_cycle	0.94291353
70	MP0005174_abnormal_tail_pigmentation	0.93529500
71	MP0002572_abnormal_emotion/affect_behav	0.90356022
72	MP0002184_abnormal_innervation	0.87881815
73	MP0003186_abnormal_redox_activity	0.87111947
74	MP0001286_abnormal_eye_development	0.85862758
75	MP0002063_abnormal_learning/memory/cond	0.85598668
76	MP0009053_abnormal_anal_canal	0.83448967
77	MP0002229_neurodegeneration	0.83137580
78	MP0002067_abnormal_sensory_capabilities	0.82049246
79	MP0002160_abnormal_reproductive_system	0.80804473
80	MP0009046_muscle_twitch	0.80758947
81	MP0002734_abnormal_mechanical_nocicepti	0.80368392
82	MP0002882_abnormal_neuron_morphology	0.79039935
83	MP0002064_seizures	0.78910804
84	MP0003011_delayed_dark_adaptation	0.78451375
85	MP0000613_abnormal_salivary_gland	0.76854174
86	MP0002233_abnormal_nose_morphology	0.76824716
87	MP0001486_abnormal_startle_reflex	0.76737460
88	MP0005391_vision/eye_phenotype	0.76060649
89	MP0003786_premature_aging	0.75677733
90	MP0003635_abnormal_synaptic_transmissio	0.75659437
91	MP0005377_hearing/vestibular/ear_phenot	0.75503966
92	MP0003878_abnormal_ear_physiology	0.75503966
93	MP0001502_abnormal_circadian_rhythm	0.75379859
94	MP0002210_abnormal_sex_determination	0.74728554
95	MP0005389_reproductive_system_phenotype	0.73966827
96	MP0001440_abnormal_grooming_behavior	0.73630683
97	MP0005084_abnormal_gallbladder_morpholo	0.72785836
98	MP0002751_abnormal_autonomic_nervous	0.72012370
99	MP0003937_abnormal_limbs/digits/tail_de	0.70544258
100	MP0001663_abnormal_digestive_system	0.68473507

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.99542383
2	Abnormality of cells of the erythroid lineage (HP:0012130)	3.77257581
3	Septo-optic dysplasia (HP:0100842)	3.77129459
4	Acute necrotizing encephalopathy (HP:0006965)	3.73064297
5	Molar tooth sign on MRI (HP:0002419)	3.68809182
6	Abnormality of midbrain morphology (HP:0002418)	3.68809182
7	Pancreatic fibrosis (HP:0100732)	3.67325098
8	Nephronophthisis (HP:0000090)	3.35209937
9	Pancreatic cysts (HP:0001737)	3.26718515
10	Macrocytic anemia (HP:0001972)	3.23436439
11	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.21727915
12	Acute encephalopathy (HP:0006846)	3.18367850
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.14137377
14	Medial flaring of the eyebrow (HP:0010747)	3.13913334
15	Abnormality of the renal medulla (HP:0100957)	3.01377814
16	True hermaphroditism (HP:0010459)	3.00518807
17	Mitochondrial inheritance (HP:0001427)	2.99958500
18	Progressive macrocephaly (HP:0004481)	2.96810127
19	Hyperglycinemia (HP:0002154)	2.94330633
20	Maternal diabetes (HP:0009800)	2.82056523
21	Increased CSF lactate (HP:0002490)	2.80659570
22	Type II lissencephaly (HP:0007260)	2.78649981
23	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.72791688
24	Absent thumb (HP:0009777)	2.71024477
25	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.70779134
26	Abnormal number of erythroid precursors (HP:0012131)	2.70720268
27	Stomatitis (HP:0010280)	2.70120726
28	Type 2 muscle fiber atrophy (HP:0003554)	2.68305821
29	Rib fusion (HP:0000902)	2.66987236
30	Optic nerve hypoplasia (HP:0000609)	2.64119372
31	Congenital stationary night blindness (HP:0007642)	2.57084871
32	Abnormality of the renal cortex (HP:0011035)	2.56893111
33	Supernumerary spleens (HP:0009799)	2.55237329
34	Pallor (HP:0000980)	2.53671077
35	Agitation (HP:0000713)	2.52576250
36	Gait imbalance (HP:0002141)	2.51712809
37	Colon cancer (HP:0003003)	2.49756699
38	Asplenia (HP:0001746)	2.49324965
39	Abnormal rod and cone electroretinograms (HP:0008323)	2.43481070
40	Pendular nystagmus (HP:0012043)	2.43127415
41	Congenital primary aphakia (HP:0007707)	2.42630485
42	3-Methylglutaconic aciduria (HP:0003535)	2.40118793
43	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.38356751
44	Abnormal pancreas size (HP:0012094)	2.35104864
45	Optic disc pallor (HP:0000543)	2.32636017
46	Nephrogenic diabetes insipidus (HP:0009806)	2.28660963
47	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.28453743
48	Absent/shortened dynein arms (HP:0200106)	2.28453743
49	Cystic liver disease (HP:0006706)	2.24957255
50	Muscle fiber atrophy (HP:0100295)	2.23070794
51	Tubular atrophy (HP:0000092)	2.22775847
52	Congenital hepatic fibrosis (HP:0002612)	2.21634077
53	Sclerocornea (HP:0000647)	2.21515177
54	Hepatocellular necrosis (HP:0001404)	2.21369205
55	Anophthalmia (HP:0000528)	2.19897862
56	Abnormal respiratory motile cilium morphology (HP:0005938)	2.15852610
57	Abnormal respiratory epithelium morphology (HP:0012253)	2.15852610
58	Polydipsia (HP:0001959)	2.15750229
59	Abnormal drinking behavior (HP:0030082)	2.15750229
60	Anencephaly (HP:0002323)	2.15588098
61	Polyuria (HP:0000103)	2.11171438
62	Cerebral edema (HP:0002181)	2.10534861
63	Hypoplasia of the radius (HP:0002984)	2.08926756
64	Abolished electroretinogram (ERG) (HP:0000550)	2.08802395
65	Constricted visual fields (HP:0001133)	2.07284210
66	Myokymia (HP:0002411)	2.06373714
67	Tubulointerstitial nephritis (HP:0001970)	2.03835286
68	Postaxial foot polydactyly (HP:0001830)	2.01816721
69	Growth hormone deficiency (HP:0000824)	2.00688947
70	Congenital, generalized hypertrichosis (HP:0004540)	1.95968827
71	Hypoplasia of the ulna (HP:0003022)	1.94801719
72	Increased hepatocellular lipid droplets (HP:0006565)	1.94388857
73	Bile duct proliferation (HP:0001408)	1.94024603
74	Abnormal biliary tract physiology (HP:0012439)	1.94024603
75	Hip dysplasia (HP:0001385)	1.92635747
76	Absent septum pellucidum (HP:0001331)	1.91349916
77	Abnormal ciliary motility (HP:0012262)	1.91114302
78	Hepatic necrosis (HP:0002605)	1.90557341
79	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.87632326
80	Abnormality of the labia minora (HP:0012880)	1.87072457
81	Forearm undergrowth (HP:0009821)	1.86927947
82	Male pseudohermaphroditism (HP:0000037)	1.86815349
83	Abnormal respiratory motile cilium physiology (HP:0012261)	1.85471636
84	Cerebellar dysplasia (HP:0007033)	1.84062865
85	Lipid accumulation in hepatocytes (HP:0006561)	1.83234949
86	Increased serum lactate (HP:0002151)	1.81535587
87	Chronic hepatic failure (HP:0100626)	1.80907804
88	Methylmalonic acidemia (HP:0002912)	1.78914713
89	Ectopic kidney (HP:0000086)	1.77434841
90	Vaginal atresia (HP:0000148)	1.76218383
91	Pancytopenia (HP:0001876)	1.76212647
92	Holoprosencephaly (HP:0001360)	1.76179727
93	Depressed nasal ridge (HP:0000457)	1.75190366
94	Abnormality of DNA repair (HP:0003254)	1.72347365
95	Tubulointerstitial abnormality (HP:0001969)	1.71094148
96	Abnormal urine output (HP:0012590)	1.71027373
97	Polyphagia (HP:0002591)	1.70909951
98	Abnormality of renal excretion (HP:0011036)	1.70697798
99	Adrenal hypoplasia (HP:0000835)	1.69973343
100	Hypomagnesemia (HP:0002917)	1.69734749

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.71929690
2	TAOK3	3.38373275
3	ADRBK2	3.08240718
4	BMPR1B	2.39972036
5	DYRK2	2.35705206
6	FRK	2.35662100
7	MAP4K2	2.34564812
8	STK39	2.31816972
9	GRK1	2.28721105
10	ZAK	2.20160357
11	PINK1	2.17246341
12	STK16	2.12733492
13	WNK3	2.03047182
14	TIE1	1.96118171
15	MAP3K9	1.96044286
16	EPHB2	1.89071898
17	LRRK2	1.88581511
18	PIK3CA	1.88238959
19	TXK	1.88187479
20	TEC	1.86090230
21	CAMKK2	1.75562113
22	PAK3	1.71236737
23	NTRK2	1.67938140
24	PASK	1.66359049
25	TYRO3	1.50743320
26	MAPK13	1.35315045
27	TNIK	1.31175099
28	VRK2	1.26905050
29	MAP3K13	1.25553314
30	NUAK1	1.22075943
31	EPHA4	1.21046916
32	WNK1	1.12915556
33	MAP3K11	1.12167179
34	ITK	1.11926401
35	OXSR1	1.09737358
36	ADRBK1	1.07240293
37	KIT	1.00101443
38	PRKCG	0.97955886
39	TLK1	0.94896771
40	KSR1	0.90733986
41	CASK	0.89163472
42	CAMKK1	0.89075816
43	CDK19	0.88712804
44	BTK	0.88034361
45	CAMK1	0.86351981
46	CDC7	0.84968622
47	PIK3CG	0.81622716
48	MAP3K12	0.81556568
49	PHKG2	0.81553802
50	PHKG1	0.81553802
51	IKBKB	0.77346596
52	INSRR	0.75667000
53	MAP4K1	0.74505227
54	PDK2	0.72127134
55	PLK2	0.70598238
56	VRK1	0.69902914
57	PLK4	0.69364055
58	PRKCE	0.69162188
59	MKNK2	0.68450467
60	ERBB2	0.68164502
61	PRKACA	0.65125493
62	PRKCQ	0.65043595
63	BCKDK	0.64509423
64	CSNK2A2	0.62952151
65	ACVR1B	0.62608556
66	PRKCH	0.60512063
67	NME1	0.58802611
68	TGFBR1	0.58413349
69	STK11	0.58187890
70	PRKCZ	0.57386269
71	MOS	0.56435276
72	NEK2	0.56159352
73	NTRK3	0.54835103
74	CSNK1E	0.54180036
75	MAPK15	0.52490286
76	AURKB	0.51212667
77	CSNK1G2	0.48792715
78	CHUK	0.48586745
79	SRPK1	0.47375183
80	OBSCN	0.47173037
81	RPS6KA5	0.46468572
82	CDK8	0.46219134
83	PRKD3	0.46117533
84	CCNB1	0.44228562
85	GRK7	0.42652664
86	PRKCA	0.40135797
87	DYRK1B	0.39544126
88	EIF2AK3	0.38708575
89	STK38L	0.38692475
90	PLK1	0.38133060
91	CSNK2A1	0.37458628
92	LIMK1	0.37237845
93	PAK6	0.37011319
94	SYK	0.36832045
95	MUSK	0.35783300
96	MAP3K4	0.35164018
97	CAMK2A	0.35091942
98	CSNK1A1	0.34058531
99	ATR	0.33203280
100	MKNK1	0.32947862

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.98198868
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.85875652
3	Parkinsons disease_Homo sapiens_hsa05012	3.01180579
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.72163356
5	Protein export_Homo sapiens_hsa03060	2.44028413
6	RNA polymerase_Homo sapiens_hsa03020	2.36764139
7	Huntingtons disease_Homo sapiens_hsa05016	2.15369726
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15030614
9	Alzheimers disease_Homo sapiens_hsa05010	2.05344870
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.03263613
11	Asthma_Homo sapiens_hsa05310	1.94618457
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.94391447
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.85862432
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78293351
15	RNA degradation_Homo sapiens_hsa03018	1.73824168
16	Basal transcription factors_Homo sapiens_hsa03022	1.68276154
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.66285200
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.61915705
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.60799771
20	Phototransduction_Homo sapiens_hsa04744	1.51616319
21	Sulfur metabolism_Homo sapiens_hsa00920	1.46591267
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41478628
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30228623
24	Nicotine addiction_Homo sapiens_hsa05033	1.29166597
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.28758265
26	Homologous recombination_Homo sapiens_hsa03440	1.28574839
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.28479929
28	Caffeine metabolism_Homo sapiens_hsa00232	1.27580374
29	Proteasome_Homo sapiens_hsa03050	1.25838466
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.24286458
31	Allograft rejection_Homo sapiens_hsa05330	1.17623146
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.14553368
33	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.13541764
34	Butanoate metabolism_Homo sapiens_hsa00650	1.12022595
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.11353142
36	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.09315810
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.08626735
38	Peroxisome_Homo sapiens_hsa04146	1.08282926
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04912219
40	One carbon pool by folate_Homo sapiens_hsa00670	1.04118176
41	Insulin secretion_Homo sapiens_hsa04911	1.03252701
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.01784944
43	Propanoate metabolism_Homo sapiens_hsa00640	0.88179027
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87928293
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.87657053
46	Sulfur relay system_Homo sapiens_hsa04122	0.87255246
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.85055445
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.83326135
49	Mismatch repair_Homo sapiens_hsa03430	0.82400353
50	Primary immunodeficiency_Homo sapiens_hsa05340	0.81740205
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77636852
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76943020
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.76281039
54	Purine metabolism_Homo sapiens_hsa00230	0.74109292
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.73221181
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71983471
57	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.71015605
58	Morphine addiction_Homo sapiens_hsa05032	0.69425220
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67909917
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.66830386
61	Metabolic pathways_Homo sapiens_hsa01100	0.65950774
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.62777611
63	Salivary secretion_Homo sapiens_hsa04970	0.62691855
64	Basal cell carcinoma_Homo sapiens_hsa05217	0.62129724
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60807264
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60409333
67	Retinol metabolism_Homo sapiens_hsa00830	0.60162323
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59582699
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58769714
70	Type I diabetes mellitus_Homo sapiens_hsa04940	0.57589004
71	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56471928
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.54068553
73	Base excision repair_Homo sapiens_hsa03410	0.52958243
74	Histidine metabolism_Homo sapiens_hsa00340	0.51845432
75	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.51023892
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50958810
77	Glutamatergic synapse_Homo sapiens_hsa04724	0.50520994
78	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.49167551
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.48986635
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48890103
81	GABAergic synapse_Homo sapiens_hsa04727	0.48566966
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48145872
83	Regulation of autophagy_Homo sapiens_hsa04140	0.48001874
84	Taste transduction_Homo sapiens_hsa04742	0.47836743
85	Spliceosome_Homo sapiens_hsa03040	0.47637639
86	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.47324429
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46361807
88	Serotonergic synapse_Homo sapiens_hsa04726	0.46000570
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45979322
90	RNA transport_Homo sapiens_hsa03013	0.45333007
91	Folate biosynthesis_Homo sapiens_hsa00790	0.45161947
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43212406
93	Olfactory transduction_Homo sapiens_hsa04740	0.41712228
94	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.40590856
95	Graft-versus-host disease_Homo sapiens_hsa05332	0.39372180
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.38966863
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.38818993
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.38484140
99	Circadian entrainment_Homo sapiens_hsa04713	0.37426364
100	Fatty acid degradation_Homo sapiens_hsa00071	0.36245217

RPL21P40

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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