RPL21P41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.02595745
2viral transcription (GO:0019083)6.40508650
3translational termination (GO:0006415)6.22901633
4gonadal mesoderm development (GO:0007506)6.12886418
5positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)6.09041007
6regulation of hypersensitivity (GO:0002883)5.65461901
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.65456277
8ATP synthesis coupled proton transport (GO:0015986)5.62317144
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.62317144
10cotranslational protein targeting to membrane (GO:0006613)5.53406903
11regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.52924459
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.47191604
13protein targeting to ER (GO:0045047)5.46627848
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.31985124
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.26314128
16positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.18650380
17protein localization to endoplasmic reticulum (GO:0070972)5.11719911
18translational elongation (GO:0006414)5.00104365
19respiratory electron transport chain (GO:0022904)4.76730423
20positive regulation of mast cell degranulation (GO:0043306)4.76722044
21positive regulation of mast cell activation involved in immune response (GO:0033008)4.76722044
22electron transport chain (GO:0022900)4.70410854
23cellular protein complex disassembly (GO:0043624)4.65021097
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.63992663
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.62075381
26chaperone-mediated protein transport (GO:0072321)4.60139872
27viral life cycle (GO:0019058)4.45176232
28maturation of SSU-rRNA (GO:0030490)4.41793328
29protein neddylation (GO:0045116)4.39053789
30protein complex biogenesis (GO:0070271)4.34644686
31pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.20967518
32DNA deamination (GO:0045006)4.19134269
33one-carbon compound transport (GO:0019755)4.16729947
34regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.15249488
35base-excision repair, AP site formation (GO:0006285)3.98112995
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.97557402
37translational initiation (GO:0006413)3.97099935
38negative regulation of execution phase of apoptosis (GO:1900118)3.95695096
39GTP biosynthetic process (GO:0006183)3.95451120
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.94717181
41positive regulation of mast cell activation (GO:0033005)3.93974477
42mitochondrial respiratory chain complex assembly (GO:0033108)3.90392552
43ribosomal small subunit biogenesis (GO:0042274)3.88264214
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.86929277
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.86929277
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.83023786
47protein complex disassembly (GO:0043241)3.78900923
48macromolecular complex disassembly (GO:0032984)3.71269660
49spliceosomal complex assembly (GO:0000245)3.69930249
50translation (GO:0006412)3.60947128
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.58695755
52NADH dehydrogenase complex assembly (GO:0010257)3.58695755
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.58695755
54nuclear-transcribed mRNA catabolic process (GO:0000956)3.55773314
55water-soluble vitamin biosynthetic process (GO:0042364)3.52636641
56protein targeting to membrane (GO:0006612)3.48958779
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.47873887
58positive regulation of T-helper 1 type immune response (GO:0002827)3.43934360
59mRNA catabolic process (GO:0006402)3.36535014
60protein-cofactor linkage (GO:0018065)3.36486870
61purine nucleoside triphosphate biosynthetic process (GO:0009145)3.35366688
62pyrimidine nucleotide catabolic process (GO:0006244)3.33265761
63ATP biosynthetic process (GO:0006754)3.32849497
64hydrogen ion transmembrane transport (GO:1902600)3.32553663
65proton transport (GO:0015992)3.25904203
66UTP biosynthetic process (GO:0006228)3.22915181
67mannosylation (GO:0097502)3.19163418
68RNA catabolic process (GO:0006401)3.19133778
69hydrogen transport (GO:0006818)3.17667329
70preassembly of GPI anchor in ER membrane (GO:0016254)3.15284449
71positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.14017068
72neural tube formation (GO:0001841)3.02702661
73pattern specification involved in kidney development (GO:0061004)3.01176395
74photoreceptor cell maintenance (GO:0045494)2.99675976
75histone mRNA metabolic process (GO:0008334)2.99460949
76positive regulation of calcium-mediated signaling (GO:0050850)2.96681529
77respiratory chain complex IV assembly (GO:0008535)2.96576022
78termination of RNA polymerase III transcription (GO:0006386)2.96161624
79transcription elongation from RNA polymerase III promoter (GO:0006385)2.96161624
80cytochrome complex assembly (GO:0017004)2.94469137
81positive regulation of alpha-beta T cell proliferation (GO:0046641)2.93746987
82ribonucleoside triphosphate biosynthetic process (GO:0009201)2.89533028
83UTP metabolic process (GO:0046051)2.83912818
84epithelial cilium movement (GO:0003351)2.82853636
85rRNA catabolic process (GO:0016075)2.82263963
86centriole replication (GO:0007099)2.80912894
87RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77728939
88nonmotile primary cilium assembly (GO:0035058)2.73261911
89ribonucleoprotein complex disassembly (GO:0032988)2.71300106
90RNA phosphodiester bond hydrolysis (GO:0090501)2.70565140
91short-term memory (GO:0007614)2.69950223
92positive regulation of T cell mediated cytotoxicity (GO:0001916)2.69914025
93maturation of 5.8S rRNA (GO:0000460)2.68962740
94mast cell activation (GO:0045576)2.68569802
95ribosomal large subunit biogenesis (GO:0042273)2.62220989
96auditory receptor cell differentiation (GO:0042491)2.62133223
97regulation of mitochondrial translation (GO:0070129)2.61805710
98intracellular protein transmembrane import (GO:0044743)2.60263664
99cell proliferation in forebrain (GO:0021846)2.59956399
100cellular component biogenesis (GO:0044085)2.59578590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.50411420
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.20134242
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43649154
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99504689
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.98198056
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86894402
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66836352
8ZNF274_21170338_ChIP-Seq_K562_Hela2.40647404
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.30151943
10EZH2_22144423_ChIP-Seq_EOC_Human2.25907736
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.24004278
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.21537257
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20620671
14ELK1_19687146_ChIP-ChIP_HELA_Human2.20433946
15VDR_23849224_ChIP-Seq_CD4+_Human2.17110465
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15001274
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.96243960
18MYC_18940864_ChIP-ChIP_HL60_Human1.90972612
19VDR_22108803_ChIP-Seq_LS180_Human1.90278688
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.88229869
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87570118
22EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.80808474
23FOXP3_21729870_ChIP-Seq_TREG_Human1.80380061
24TP53_22573176_ChIP-Seq_HFKS_Human1.75124926
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73470667
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.73463411
27EWS_26573619_Chip-Seq_HEK293_Human1.71087513
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71005357
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.68802875
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.63293152
31AR_20517297_ChIP-Seq_VCAP_Human1.59559756
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57370841
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55500124
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51760133
35GATA3_21878914_ChIP-Seq_MCF-7_Human1.48480946
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48109207
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46510180
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.46240043
39TAF2_19829295_ChIP-Seq_ESCs_Human1.43402881
40RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41683632
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.41194669
42PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.40608684
43TAF15_26573619_Chip-Seq_HEK293_Human1.35905586
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.35298470
45ERG_20517297_ChIP-Seq_VCAP_Human1.33650395
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33312580
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31565865
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30716392
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.30716392
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30079507
51P300_19829295_ChIP-Seq_ESCs_Human1.25379986
52NANOG_20526341_ChIP-Seq_ESCs_Human1.23781918
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.20878339
54FUS_26573619_Chip-Seq_HEK293_Human1.20163704
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19405151
56GATA3_26560356_Chip-Seq_TH2_Human1.17652691
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.15299745
58GATA6_21074721_ChIP-Seq_CACO-2_Human1.13589305
59MYC_19829295_ChIP-Seq_ESCs_Human1.13253601
60SOX2_19829295_ChIP-Seq_ESCs_Human1.09945030
61NANOG_19829295_ChIP-Seq_ESCs_Human1.09945030
62GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09910775
63TCF4_22108803_ChIP-Seq_LS180_Human1.09599641
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.09580981
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09429071
66GBX2_23144817_ChIP-Seq_PC3_Human1.09124199
67RBPJ_21746931_ChIP-Seq_IB4_Human1.08163850
68RNF2_27304074_Chip-Seq_NSC_Mouse1.07495971
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05867297
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04584117
71ETV1_20927104_ChIP-Seq_GIST48_Human1.04296119
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03179784
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02184412
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01973688
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.01759844
76TTF2_22483619_ChIP-Seq_HELA_Human1.01632991
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99753100
78FOXH1_21741376_ChIP-Seq_EPCs_Human0.99258302
79ER_23166858_ChIP-Seq_MCF-7_Human0.98522698
80EZH2_27304074_Chip-Seq_ESCs_Mouse0.97327263
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97162552
82CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96665284
83POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96535621
84HOXB7_26014856_ChIP-Seq_BT474_Human0.96510143
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96351651
86STAT1_20625510_ChIP-Seq_HELA_Human0.96250064
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96017713
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.95483503
89PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95337038
90PHF8_20622853_ChIP-Seq_HELA_Human0.94000215
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.93657698
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93262877
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93050642
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.92643151
95EGR1_19032775_ChIP-ChIP_M12_Human0.92163368
96ERA_21632823_ChIP-Seq_H3396_Human0.91971024
97P53_22387025_ChIP-Seq_ESCs_Mouse0.90731030
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90612412
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89638452
100GABP_19822575_ChIP-Seq_HepG2_Human0.89306524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.39757273
2MP0009379_abnormal_foot_pigmentation3.90411883
3MP0002102_abnormal_ear_morphology3.81123447
4MP0002653_abnormal_ependyma_morphology3.52682008
5MP0003787_abnormal_imprinting2.96221656
6MP0000516_abnormal_urinary_system2.79670083
7MP0005367_renal/urinary_system_phenotyp2.79670083
8MP0002837_dystrophic_cardiac_calcinosis2.72863725
9MP0000372_irregular_coat_pigmentation2.64547515
10MP0006292_abnormal_olfactory_placode2.62767159
11MP0005671_abnormal_response_to2.50289360
12MP0001835_abnormal_antigen_presentation2.47648089
13MP0005377_hearing/vestibular/ear_phenot2.13902536
14MP0003878_abnormal_ear_physiology2.13902536
15MP0008789_abnormal_olfactory_epithelium2.08322028
16MP0003786_premature_aging2.07240047
17MP0003646_muscle_fatigue1.99574540
18MP0003011_delayed_dark_adaptation1.94192760
19MP0001984_abnormal_olfaction1.92677569
20MP0008995_early_reproductive_senescence1.89146681
21MP0006072_abnormal_retinal_apoptosis1.81286549
22MP0001485_abnormal_pinna_reflex1.74889935
23MP0005253_abnormal_eye_physiology1.68944694
24MP0005551_abnormal_eye_electrophysiolog1.67457172
25MP0002876_abnormal_thyroid_physiology1.65823558
26MP0005360_urolithiasis1.54119266
27MP0005075_abnormal_melanosome_morpholog1.54036833
28MP0005394_taste/olfaction_phenotype1.51526448
29MP0005499_abnormal_olfactory_system1.51526448
30MP0001986_abnormal_taste_sensitivity1.51434097
31MP0003136_yellow_coat_color1.45294562
32MP0008875_abnormal_xenobiotic_pharmacok1.38970642
33MP0008872_abnormal_physiological_respon1.37284021
34MP0002234_abnormal_pharynx_morphology1.34141764
35MP0001905_abnormal_dopamine_level1.30170408
36MP0003121_genomic_imprinting1.29220907
37MP0001529_abnormal_vocalization1.25445177
38MP0000427_abnormal_hair_cycle1.23933362
39MP0005408_hypopigmentation1.22461383
40MP0002938_white_spotting1.19991594
41MP0002736_abnormal_nociception_after1.18837058
42MP0003252_abnormal_bile_duct1.18193027
43MP0002277_abnormal_respiratory_mucosa1.17985541
44MP0004142_abnormal_muscle_tone1.14522825
45MP0004742_abnormal_vestibular_system1.14037056
46MP0006036_abnormal_mitochondrial_physio1.13459720
47MP0003283_abnormal_digestive_organ1.09318987
48MP0005387_immune_system_phenotype1.07745148
49MP0001790_abnormal_immune_system1.07745148
50MP0001486_abnormal_startle_reflex1.05867375
51MP0008775_abnormal_heart_ventricle1.05550858
52MP0005645_abnormal_hypothalamus_physiol1.05236038
53MP0001968_abnormal_touch/_nociception1.04372532
54MP0003806_abnormal_nucleotide_metabolis1.03819160
55MP0000383_abnormal_hair_follicle1.02558051
56MP0001293_anophthalmia1.01002092
57MP0001756_abnormal_urination1.00629585
58MP0003195_calcinosis0.98868988
59MP0000569_abnormal_digit_pigmentation0.98599308
60MP0005195_abnormal_posterior_eye0.97840852
61MP0002095_abnormal_skin_pigmentation0.97008247
62MP0009785_altered_susceptibility_to0.96808542
63MP0000049_abnormal_middle_ear0.96272562
64MP0001800_abnormal_humoral_immune0.95394365
65MP0000631_abnormal_neuroendocrine_gland0.93918492
66MP0009764_decreased_sensitivity_to0.92896724
67MP0003866_abnormal_defecation0.91348366
68MP0005332_abnormal_amino_acid0.90916878
69MP0006276_abnormal_autonomic_nervous0.89878677
70MP0009745_abnormal_behavioral_response0.85503296
71MP0002751_abnormal_autonomic_nervous0.83608067
72MP0000026_abnormal_inner_ear0.82756227
73MP0004133_heterotaxia0.82657477
74MP0009046_muscle_twitch0.80427874
75MP0001873_stomach_inflammation0.79178979
76MP0002233_abnormal_nose_morphology0.78415888
77MP0002272_abnormal_nervous_system0.77684481
78MP0002723_abnormal_immune_serum0.75946444
79MP0000534_abnormal_ureter_morphology0.75109970
80MP0002006_tumorigenesis0.74409085
81MP0003938_abnormal_ear_development0.73463233
82MP0001970_abnormal_pain_threshold0.71605416
83MP0005646_abnormal_pituitary_gland0.71558510
84MP0001501_abnormal_sleep_pattern0.71268182
85MP0002452_abnormal_antigen_presenting0.71044822
86MP0002148_abnormal_hypersensitivity_rea0.70942119
87MP0000685_abnormal_immune_system0.69971063
88MP0005636_abnormal_mineral_homeostasis0.69002367
89MP0001963_abnormal_hearing_physiology0.68436288
90MP0001764_abnormal_homeostasis0.67761646
91MP0008058_abnormal_DNA_repair0.67128425
92MP0005174_abnormal_tail_pigmentation0.65753073
93MP0005389_reproductive_system_phenotype0.65725436
94MP0005166_decreased_susceptibility_to0.65206978
95MP0002160_abnormal_reproductive_system0.63167800
96MP0002928_abnormal_bile_duct0.62505238
97MP0004019_abnormal_vitamin_homeostasis0.62026480
98MP0005410_abnormal_fertilization0.61873668
99MP0003718_maternal_effect0.61755229
100MP0002282_abnormal_trachea_morphology0.60706862

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.89572373
2Abnormal mitochondria in muscle tissue (HP:0008316)4.55452583
3Mitochondrial inheritance (HP:0001427)4.54950007
4Congenital, generalized hypertrichosis (HP:0004540)4.47696666
5Hepatocellular necrosis (HP:0001404)4.25135919
6Progressive macrocephaly (HP:0004481)4.11257129
7Acute encephalopathy (HP:0006846)4.10234645
8Increased CSF lactate (HP:0002490)4.10093738
93-Methylglutaconic aciduria (HP:0003535)3.69000933
10Hepatic necrosis (HP:0002605)3.57699123
11Pancreatic fibrosis (HP:0100732)3.44066223
12Abnormal drinking behavior (HP:0030082)3.27469370
13Polydipsia (HP:0001959)3.27469370
14Hyperglycinemia (HP:0002154)3.24218511
15Stomatitis (HP:0010280)3.22834290
16Abnormality of midbrain morphology (HP:0002418)3.18142199
17Molar tooth sign on MRI (HP:0002419)3.18142199
18Medial flaring of the eyebrow (HP:0010747)3.16847125
19Renal Fanconi syndrome (HP:0001994)3.15489395
20Leukodystrophy (HP:0002415)3.14373459
21Pancreatic cysts (HP:0001737)3.08593530
22Tubular atrophy (HP:0000092)3.05406201
23Reticulocytopenia (HP:0001896)3.03090513
24Type II lissencephaly (HP:0007260)3.01065721
25Supernumerary spleens (HP:0009799)2.95081160
26Optic disc pallor (HP:0000543)2.92505406
27Nephronophthisis (HP:0000090)2.90134621
28Cerebral edema (HP:0002181)2.86526753
29Septo-optic dysplasia (HP:0100842)2.85887713
30Abnormality of the renal cortex (HP:0011035)2.82622807
31Aplastic anemia (HP:0001915)2.74248442
32Renal cortical cysts (HP:0000803)2.69307912
33Congenital stationary night blindness (HP:0007642)2.67315977
34IgG deficiency (HP:0004315)2.66218695
35Abnormality of cells of the erythroid lineage (HP:0012130)2.55449114
36True hermaphroditism (HP:0010459)2.52386841
37Retinal dysplasia (HP:0007973)2.49704044
38Asplenia (HP:0001746)2.49026625
39Hypoplastic pelvis (HP:0008839)2.48044295
40Macrocytic anemia (HP:0001972)2.47457498
41Abnormality of alanine metabolism (HP:0010916)2.39331300
42Hyperalaninemia (HP:0003348)2.39331300
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39331300
44Congenital primary aphakia (HP:0007707)2.38500307
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.35753437
46Increased IgM level (HP:0003496)2.35420883
47Abnormal respiratory motile cilium morphology (HP:0005938)2.34559731
48Abnormal respiratory epithelium morphology (HP:0012253)2.34559731
49Gait imbalance (HP:0002141)2.33209780
50Increased serum lactate (HP:0002151)2.32327774
51Lactic acidosis (HP:0003128)2.31544435
52Abnormality of the renal medulla (HP:0100957)2.30267703
53Increased intramyocellular lipid droplets (HP:0012240)2.19618501
54Elevated erythrocyte sedimentation rate (HP:0003565)2.19610188
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18098736
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18098736
57Abnormal auditory evoked potentials (HP:0006958)2.17107363
58Abolished electroretinogram (ERG) (HP:0000550)2.15428730
59Polyuria (HP:0000103)2.14711024
60Nephrogenic diabetes insipidus (HP:0009806)2.14462678
61Chronic sinusitis (HP:0011109)2.13155726
62Stenosis of the external auditory canal (HP:0000402)2.12152092
63Spontaneous abortion (HP:0005268)2.07844178
64Generalized aminoaciduria (HP:0002909)2.07763507
65Spastic paraparesis (HP:0002313)2.07444623
66Increased hepatocellular lipid droplets (HP:0006565)2.06574419
67Colon cancer (HP:0003003)2.06371157
68CNS demyelination (HP:0007305)2.05423358
69Abnormality of renal resorption (HP:0011038)2.04819040
70Abnormal ciliary motility (HP:0012262)2.03652464
71Hypoplasia of the ulna (HP:0003022)2.03364956
72Abnormal respiratory motile cilium physiology (HP:0012261)2.03051271
73Respiratory failure (HP:0002878)2.02556880
74Entropion (HP:0000621)1.94843243
75Hypoproteinemia (HP:0003075)1.93466989
76Sclerocornea (HP:0000647)1.93343331
77Lipid accumulation in hepatocytes (HP:0006561)1.90685142
78Rib fusion (HP:0000902)1.89526454
79Postaxial foot polydactyly (HP:0001830)1.88593751
80Abnormality of glycine metabolism (HP:0010895)1.86976506
81Abnormality of serine family amino acid metabolism (HP:0010894)1.86976506
82Pancytopenia (HP:0001876)1.86917136
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86339673
84Male pseudohermaphroditism (HP:0000037)1.84249090
85Absent thumb (HP:0009777)1.83832961
86Cystic liver disease (HP:0006706)1.82053689
87Papilledema (HP:0001085)1.81786271
88Postaxial hand polydactyly (HP:0001162)1.80879792
89X-linked dominant inheritance (HP:0001423)1.79414329
90Abnormal rod and cone electroretinograms (HP:0008323)1.78488308
91Anhidrosis (HP:0000970)1.77915279
92Dynein arm defect of respiratory motile cilia (HP:0012255)1.77347770
93Absent/shortened dynein arms (HP:0200106)1.77347770
94Abnormal number of erythroid precursors (HP:0012131)1.77259584
95Increased muscle lipid content (HP:0009058)1.76478614
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73673297
97Abnormal urine output (HP:0012590)1.73663365
98Exercise intolerance (HP:0003546)1.73391309
99Forearm undergrowth (HP:0009821)1.72137552
100Hyperglycinuria (HP:0003108)1.72102002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.58012431
2MAP4K14.10499964
3WNK43.40644659
4ADRBK22.62415322
5FRK2.62142655
6STK392.55700281
7TXK2.41684718
8PIK3CA1.99914483
9OXSR11.89649734
10VRK21.78576050
11CSNK1G21.67825088
12TEC1.64101437
13GRK11.61274207
14PLK41.56895668
15NME11.50540367
16WNK31.39565090
17KDR1.37587047
18TAOK31.37392341
19BTK1.30906488
20CSNK1G31.29529898
21PIM21.25951217
22NUAK11.21991512
23SCYL21.16847993
24TNK21.15878161
25TYK21.14998644
26PLK21.14393046
27NEK91.13490328
28BCKDK1.13303356
29ARAF1.12466532
30EIF2AK11.12051923
31PAK31.11067378
32CSNK1G11.08972679
33MAP4K21.08631031
34PRKCQ1.08590131
35TLK11.04380238
36VRK11.00808501
37LYN1.00459644
38IKBKB0.98638182
39PASK0.91799061
40DYRK20.91653088
41MAPK150.90981468
42LRRK20.84615780
43INSRR0.83842658
44ITK0.83813772
45ABL20.83477274
46CSNK1A1L0.83312794
47PTK2B0.81095423
48PINK10.79732950
49CSNK2A20.78339354
50CAMKK20.78014064
51TIE10.76864022
52RPS6KA50.75423410
53STK160.74319462
54IKBKE0.73893797
55NTRK20.73263956
56NME20.72193330
57SYK0.72134538
58GRK60.71078716
59ADRBK10.70973973
60LCK0.70962831
61DYRK1A0.70424703
62BMPR1B0.67345887
63MATK0.66943476
64OBSCN0.66914708
65PRKG10.66662992
66CSNK2A10.66294765
67MAP3K130.66123760
68MAP3K120.62412924
69GRK50.61935289
70IGF1R0.60016284
71SRPK10.59857931
72PRKCG0.58468776
73CAMK2A0.58466114
74STK38L0.57443417
75CDC70.56393890
76PIK3CG0.56165452
77BRAF0.56058329
78PHKG10.54942962
79PHKG20.54942962
80MYLK0.54299218
81PRKACA0.53149106
82CHEK20.51200114
83CSNK1A10.50053708
84DYRK30.49449183
85AURKB0.48727736
86MAP2K60.46540691
87KIT0.44797747
88MAP3K70.44392664
89CAMKK10.43817457
90PRKCE0.42103326
91CSF1R0.42061832
92PLK10.41723380
93ZAK0.41288526
94DAPK30.40627285
95BRSK20.40299015
96CHUK0.39706065
97CSNK1E0.38911581
98PRKCD0.38808424
99NEK10.38661111
100BRSK10.38505243

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.29909877
2Oxidative phosphorylation_Homo sapiens_hsa001904.62411009
3Asthma_Homo sapiens_hsa053103.90195815
4Parkinsons disease_Homo sapiens_hsa050123.76458924
5Protein export_Homo sapiens_hsa030602.78196874
6Alzheimers disease_Homo sapiens_hsa050102.75448329
7Proteasome_Homo sapiens_hsa030502.72115736
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.61293480
9Huntingtons disease_Homo sapiens_hsa050162.54570568
10Primary immunodeficiency_Homo sapiens_hsa053402.44513312
11Cardiac muscle contraction_Homo sapiens_hsa042602.42937914
12Homologous recombination_Homo sapiens_hsa034402.21432619
13RNA polymerase_Homo sapiens_hsa030202.14607586
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09504271
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.01229627
16Autoimmune thyroid disease_Homo sapiens_hsa053201.98808399
17Allograft rejection_Homo sapiens_hsa053301.97593612
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81035025
19RNA degradation_Homo sapiens_hsa030181.72013322
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60291887
21Linoleic acid metabolism_Homo sapiens_hsa005911.58013265
22Graft-versus-host disease_Homo sapiens_hsa053321.41280717
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26646959
24Antigen processing and presentation_Homo sapiens_hsa046121.22872837
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19050886
26Basal transcription factors_Homo sapiens_hsa030221.14249607
27Type I diabetes mellitus_Homo sapiens_hsa049401.10073859
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09194817
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09186098
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08490553
31Hematopoietic cell lineage_Homo sapiens_hsa046401.07034324
32Rheumatoid arthritis_Homo sapiens_hsa053231.03189204
33Nucleotide excision repair_Homo sapiens_hsa034201.03056032
34Fanconi anemia pathway_Homo sapiens_hsa034601.02149087
35Arachidonic acid metabolism_Homo sapiens_hsa005900.98149027
36Ether lipid metabolism_Homo sapiens_hsa005650.95355123
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91544960
38Pyrimidine metabolism_Homo sapiens_hsa002400.88936924
39Viral myocarditis_Homo sapiens_hsa054160.88670493
40Steroid hormone biosynthesis_Homo sapiens_hsa001400.86265017
41Nicotine addiction_Homo sapiens_hsa050330.85891147
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84058876
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83626381
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83511023
45Spliceosome_Homo sapiens_hsa030400.79347017
46Systemic lupus erythematosus_Homo sapiens_hsa053220.76293726
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76262750
48Fat digestion and absorption_Homo sapiens_hsa049750.72626049
49T cell receptor signaling pathway_Homo sapiens_hsa046600.71861323
50Phototransduction_Homo sapiens_hsa047440.69732264
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68670568
52Caffeine metabolism_Homo sapiens_hsa002320.66636679
53Chemical carcinogenesis_Homo sapiens_hsa052040.64264105
54Olfactory transduction_Homo sapiens_hsa047400.61173371
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61097849
56Malaria_Homo sapiens_hsa051440.60755764
57Metabolic pathways_Homo sapiens_hsa011000.59673321
58Retinol metabolism_Homo sapiens_hsa008300.57584096
59Nitrogen metabolism_Homo sapiens_hsa009100.57446687
60Collecting duct acid secretion_Homo sapiens_hsa049660.56864938
61Selenocompound metabolism_Homo sapiens_hsa004500.56008068
62Mismatch repair_Homo sapiens_hsa034300.55698981
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54361740
64Ovarian steroidogenesis_Homo sapiens_hsa049130.54280988
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53763474
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53004385
67Sulfur metabolism_Homo sapiens_hsa009200.52471445
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51363530
69Tryptophan metabolism_Homo sapiens_hsa003800.50354326
70Non-homologous end-joining_Homo sapiens_hsa034500.47217248
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47177708
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46820269
73One carbon pool by folate_Homo sapiens_hsa006700.45776248
74Morphine addiction_Homo sapiens_hsa050320.45029994
75Peroxisome_Homo sapiens_hsa041460.44973672
76Purine metabolism_Homo sapiens_hsa002300.42961571
77RNA transport_Homo sapiens_hsa030130.42912632
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.42183611
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.41455592
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40992341
81Staphylococcus aureus infection_Homo sapiens_hsa051500.38809068
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.38123301
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.37848475
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36184616
85Taste transduction_Homo sapiens_hsa047420.34463954
86African trypanosomiasis_Homo sapiens_hsa051430.34357366
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34240707
88Steroid biosynthesis_Homo sapiens_hsa001000.33018810
89Tyrosine metabolism_Homo sapiens_hsa003500.29693179
90GABAergic synapse_Homo sapiens_hsa047270.24462768
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23436222
92Vitamin B6 metabolism_Homo sapiens_hsa007500.22903942
93Sulfur relay system_Homo sapiens_hsa041220.22738634
94DNA replication_Homo sapiens_hsa030300.19225014
95Histidine metabolism_Homo sapiens_hsa003400.17563346
96Notch signaling pathway_Homo sapiens_hsa043300.16577177
97Basal cell carcinoma_Homo sapiens_hsa052170.15679382
98Circadian rhythm_Homo sapiens_hsa047100.14879823
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13978769
100Epstein-Barr virus infection_Homo sapiens_hsa051690.13895267

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