RPL21P42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.40525365
2ribosomal small subunit assembly (GO:0000028)6.36576597
3translational termination (GO:0006415)6.22363224
4ribosomal small subunit biogenesis (GO:0042274)5.45239163
5behavioral response to nicotine (GO:0035095)5.31896214
6ATP synthesis coupled proton transport (GO:0015986)5.31751233
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.31751233
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.18330692
9cotranslational protein targeting to membrane (GO:0006613)5.11744498
10protein targeting to ER (GO:0045047)5.08967768
11translational elongation (GO:0006414)4.99769150
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.97390845
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.91297607
14protein localization to endoplasmic reticulum (GO:0070972)4.78247561
15chaperone-mediated protein transport (GO:0072321)4.71512642
16cellular protein complex disassembly (GO:0043624)4.66878545
17maturation of SSU-rRNA (GO:0030490)4.64610957
18viral life cycle (GO:0019058)4.57496007
19positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.39931250
20GTP biosynthetic process (GO:0006183)4.38260726
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.30464424
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.18098223
23protein neddylation (GO:0045116)4.18092391
24protein complex disassembly (GO:0043241)3.93112682
25regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.89131797
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.81401569
27platelet dense granule organization (GO:0060155)3.81065065
28nonmotile primary cilium assembly (GO:0035058)3.73177317
29protein complex biogenesis (GO:0070271)3.72675996
30translational initiation (GO:0006413)3.71374672
31ribosomal large subunit biogenesis (GO:0042273)3.71365056
32macromolecular complex disassembly (GO:0032984)3.71063113
33UTP biosynthetic process (GO:0006228)3.66456397
34electron transport chain (GO:0022900)3.61411252
35respiratory electron transport chain (GO:0022904)3.60370717
36parturition (GO:0007567)3.53943345
37water-soluble vitamin biosynthetic process (GO:0042364)3.51694321
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.50506042
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.50506042
40purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.49983839
41substrate-independent telencephalic tangential migration (GO:0021826)3.48150772
42substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.48150772
43negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.47594732
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.40480382
45protein targeting to membrane (GO:0006612)3.37914146
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35825393
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.35825393
48NADH dehydrogenase complex assembly (GO:0010257)3.35825393
49positive regulation of cell fate commitment (GO:0010455)3.34367469
50DNA deamination (GO:0045006)3.34279567
51UTP metabolic process (GO:0046051)3.26826133
52mitochondrial respiratory chain complex assembly (GO:0033108)3.22163877
53ATP biosynthetic process (GO:0006754)3.22106927
54cell proliferation in forebrain (GO:0021846)3.21524355
55neuron fate determination (GO:0048664)3.16766373
56translation (GO:0006412)3.16656107
57kidney morphogenesis (GO:0060993)3.10989039
58nuclear-transcribed mRNA catabolic process (GO:0000956)3.06898428
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.01690976
60hydrogen ion transmembrane transport (GO:1902600)3.00005153
61regulation of cilium movement (GO:0003352)2.99738582
62sequestering of actin monomers (GO:0042989)2.98509379
63cellular component biogenesis (GO:0044085)2.95064065
64ribonucleoside triphosphate biosynthetic process (GO:0009201)2.91554999
65mRNA catabolic process (GO:0006402)2.90540595
66somite development (GO:0061053)2.87772440
67ribonucleoprotein complex biogenesis (GO:0022613)2.83676587
68proton transport (GO:0015992)2.82562543
69nucleoside diphosphate phosphorylation (GO:0006165)2.82153617
70negative regulation of DNA-templated transcription, elongation (GO:0032785)2.81707033
71cellular response to nicotine (GO:0071316)2.78708260
72protein-cofactor linkage (GO:0018065)2.77557003
73positive regulation of interleukin-17 production (GO:0032740)2.76904210
74hydrogen transport (GO:0006818)2.75445301
75CTP biosynthetic process (GO:0006241)2.69541899
76CTP metabolic process (GO:0046036)2.69541899
77respiratory chain complex IV assembly (GO:0008535)2.69527079
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68762370
79epithelial cilium movement (GO:0003351)2.68738482
80positive regulation of respiratory burst (GO:0060267)2.67821543
81positive regulation of defense response to virus by host (GO:0002230)2.64736400
82transmission of nerve impulse (GO:0019226)2.64605529
83RNA catabolic process (GO:0006401)2.62217487
84regulation of mesoderm development (GO:2000380)2.61668273
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.61470627
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60603406
87regulation of immunoglobulin secretion (GO:0051023)2.60204643
88kynurenine metabolic process (GO:0070189)2.58771200
89hypothalamus development (GO:0021854)2.52181777
90cytochrome complex assembly (GO:0017004)2.51645614
91glycerophospholipid catabolic process (GO:0046475)2.50275313
92regulation of isotype switching to IgG isotypes (GO:0048302)2.48511520
93epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45393003
94synaptic transmission, cholinergic (GO:0007271)2.45066175
95pyrimidine nucleobase catabolic process (GO:0006208)2.43904627
96positive regulation of activated T cell proliferation (GO:0042104)2.42216879
97negative regulation of response to food (GO:0032096)2.40619396
98negative regulation of appetite (GO:0032099)2.40619396
99ubiquinone metabolic process (GO:0006743)2.40013083
100negative regulation of mast cell activation (GO:0033004)2.39623114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.86285711
2VDR_22108803_ChIP-Seq_LS180_Human3.43926698
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.23848879
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.11569420
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.93443328
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62067353
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55454275
8ZNF274_21170338_ChIP-Seq_K562_Hela2.42695326
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.36250648
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.20904773
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07840635
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.06406404
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06104811
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01945435
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.96192716
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85540044
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.85273224
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83890435
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.81076001
20IRF1_19129219_ChIP-ChIP_H3396_Human1.79453888
21IGF1R_20145208_ChIP-Seq_DFB_Human1.77851303
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.69658395
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67979668
24TP53_22573176_ChIP-Seq_HFKS_Human1.65929922
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64645004
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64322454
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.62985557
28RNF2_27304074_Chip-Seq_NSC_Mouse1.56597882
29TAF15_26573619_Chip-Seq_HEK293_Human1.56271085
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55585525
31EWS_26573619_Chip-Seq_HEK293_Human1.55184789
32REST_21632747_ChIP-Seq_MESCs_Mouse1.54726940
33MYC_18940864_ChIP-ChIP_HL60_Human1.50614948
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48252208
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47086218
36GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.47061645
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44284316
38VDR_23849224_ChIP-Seq_CD4+_Human1.41139389
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38848495
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.38208873
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.35654581
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34419181
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31794316
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29663190
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28804127
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25736277
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.25589125
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.25057447
49FOXP3_21729870_ChIP-Seq_TREG_Human1.23178954
50FUS_26573619_Chip-Seq_HEK293_Human1.23038307
51NCOR_22424771_ChIP-Seq_293T_Human1.21545408
52CBP_20019798_ChIP-Seq_JUKART_Human1.21201690
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21201690
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.21084745
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21084745
56NANOG_20526341_ChIP-Seq_ESCs_Human1.20763914
57P300_19829295_ChIP-Seq_ESCs_Human1.18774872
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.18658328
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18374432
60CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.17685774
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17611627
62TAF2_19829295_ChIP-Seq_ESCs_Human1.16474759
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16259598
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16259598
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13952581
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13692653
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13053363
68NANOG_19829295_ChIP-Seq_ESCs_Human1.12406112
69SOX2_19829295_ChIP-Seq_ESCs_Human1.12406112
70TTF2_22483619_ChIP-Seq_HELA_Human1.12375649
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12219536
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10344145
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10344145
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09007103
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08854109
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08810931
77ELK1_19687146_ChIP-ChIP_HELA_Human1.08229402
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08224221
79MYC_19829295_ChIP-Seq_ESCs_Human1.08060451
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07589395
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05518714
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05518485
83MYC_18555785_ChIP-Seq_MESCs_Mouse1.00686847
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00685421
85SRF_21415370_ChIP-Seq_HL-1_Mouse0.99995129
86ERA_21632823_ChIP-Seq_H3396_Human0.99910941
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98456166
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97335366
89BCAT_22108803_ChIP-Seq_LS180_Human0.96854316
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96153550
91CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96035165
92TP53_20018659_ChIP-ChIP_R1E_Mouse0.94550867
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94189494
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93478438
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.93201242
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92667935
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92542850
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92480362
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92097594
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91572500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.88848381
2MP0006292_abnormal_olfactory_placode4.11224531
3MP0003787_abnormal_imprinting2.89496015
4MP0008789_abnormal_olfactory_epithelium2.48868983
5MP0005646_abnormal_pituitary_gland2.42592522
6MP0001188_hyperpigmentation2.34895578
7MP0002102_abnormal_ear_morphology2.32504036
8MP0008877_abnormal_DNA_methylation2.29511781
9MP0006072_abnormal_retinal_apoptosis2.27558324
10MP0002163_abnormal_gland_morphology2.25215299
11MP0004885_abnormal_endolymph2.23382058
12MP0005499_abnormal_olfactory_system1.98956699
13MP0005394_taste/olfaction_phenotype1.98956699
14MP0002638_abnormal_pupillary_reflex1.97409199
15MP0005377_hearing/vestibular/ear_phenot1.81928369
16MP0003878_abnormal_ear_physiology1.81928369
17MP0004142_abnormal_muscle_tone1.81416940
18MP0008875_abnormal_xenobiotic_pharmacok1.80280165
19MP0002272_abnormal_nervous_system1.79706227
20MP0001348_abnormal_lacrimal_gland1.73512058
21MP0005551_abnormal_eye_electrophysiolog1.64610563
22MP0002653_abnormal_ependyma_morphology1.62505370
23MP0001529_abnormal_vocalization1.62295768
24MP0002938_white_spotting1.59372944
25MP0001986_abnormal_taste_sensitivity1.58625625
26MP0001293_anophthalmia1.54793636
27MP0003011_delayed_dark_adaptation1.53523809
28MP0010030_abnormal_orbit_morphology1.52015215
29MP0003123_paternal_imprinting1.49827979
30MP0004742_abnormal_vestibular_system1.46014949
31MP0002234_abnormal_pharynx_morphology1.43279567
32MP0008872_abnormal_physiological_respon1.43096731
33MP0006276_abnormal_autonomic_nervous1.39219498
34MP0003136_yellow_coat_color1.36949231
35MP0005174_abnormal_tail_pigmentation1.35375835
36MP0001968_abnormal_touch/_nociception1.35117123
37MP0005671_abnormal_response_to1.35042272
38MP0003880_abnormal_central_pattern1.34072731
39MP0001919_abnormal_reproductive_system1.33470529
40MP0002876_abnormal_thyroid_physiology1.32207715
41MP0005645_abnormal_hypothalamus_physiol1.31857357
42MP0001905_abnormal_dopamine_level1.29738404
43MP0002736_abnormal_nociception_after1.29615535
44MP0009745_abnormal_behavioral_response1.28323093
45MP0002160_abnormal_reproductive_system1.27078665
46MP0003195_calcinosis1.26842403
47MP0002557_abnormal_social/conspecific_i1.25784794
48MP0000778_abnormal_nervous_system1.24746224
49MP0000049_abnormal_middle_ear1.23656357
50MP0005389_reproductive_system_phenotype1.22704143
51MP0000631_abnormal_neuroendocrine_gland1.19737024
52MP0000026_abnormal_inner_ear1.19556171
53MP0005195_abnormal_posterior_eye1.14802968
54MP0003646_muscle_fatigue1.14310022
55MP0001485_abnormal_pinna_reflex1.13516079
56MP0005253_abnormal_eye_physiology1.13028794
57MP0002822_catalepsy1.12349150
58MP0002184_abnormal_innervation1.11570454
59MP0005379_endocrine/exocrine_gland_phen1.11318823
60MP0002138_abnormal_hepatobiliary_system1.10277918
61MP0009046_muscle_twitch1.09879889
62MP0003121_genomic_imprinting1.09039425
63MP0003122_maternal_imprinting1.08773837
64MP0001486_abnormal_startle_reflex1.08522233
65MP0001984_abnormal_olfaction1.08228237
66MP0005187_abnormal_penis_morphology1.05662866
67MP0002752_abnormal_somatic_nervous1.04913842
68MP0004133_heterotaxia1.03706524
69MP0005084_abnormal_gallbladder_morpholo1.03462286
70MP0003315_abnormal_perineum_morphology1.00258045
71MP0002837_dystrophic_cardiac_calcinosis0.99484902
72MP0002095_abnormal_skin_pigmentation0.99222329
73MP0004145_abnormal_muscle_electrophysio0.97275159
74MP0003879_abnormal_hair_cell0.96903728
75MP0001970_abnormal_pain_threshold0.96113269
76MP0001963_abnormal_hearing_physiology0.94206587
77MP0001440_abnormal_grooming_behavior0.93904158
78MP0003937_abnormal_limbs/digits/tail_de0.92711463
79MP0001346_abnormal_lacrimal_gland0.91504198
80MP0002572_abnormal_emotion/affect_behav0.89523429
81MP0002733_abnormal_thermal_nociception0.88547320
82MP0003938_abnormal_ear_development0.85079767
83MP0003635_abnormal_synaptic_transmissio0.83971917
84MP0002063_abnormal_learning/memory/cond0.83900957
85MP0000372_irregular_coat_pigmentation0.81608261
86MP0005248_abnormal_Harderian_gland0.81250193
87MP0003866_abnormal_defecation0.78889241
88MP0009764_decreased_sensitivity_to0.78676263
89MP0002210_abnormal_sex_determination0.78385108
90MP0001542_abnormal_bone_strength0.77544849
91MP0000955_abnormal_spinal_cord0.75229458
92MP0005085_abnormal_gallbladder_physiolo0.73195768
93MP0001663_abnormal_digestive_system0.72917352
94MP0002734_abnormal_mechanical_nocicepti0.72223884
95MP0001286_abnormal_eye_development0.72083969
96MP0002064_seizures0.71744291
97MP0001835_abnormal_antigen_presentation0.71503678
98MP0005391_vision/eye_phenotype0.70981066
99MP0000569_abnormal_digit_pigmentation0.68816925
100MP0000566_synostosis0.67978152

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.49202036
2Molar tooth sign on MRI (HP:0002419)3.88870385
3Abnormality of midbrain morphology (HP:0002418)3.88870385
4Pancreatic cysts (HP:0001737)3.79306513
5Abnormality of cells of the erythroid lineage (HP:0012130)3.64547496
6Septo-optic dysplasia (HP:0100842)3.61475127
7Acute necrotizing encephalopathy (HP:0006965)3.59202600
8Pancreatic fibrosis (HP:0100732)3.58703074
9Nephronophthisis (HP:0000090)3.47007339
10Congenital stationary night blindness (HP:0007642)3.36391897
11True hermaphroditism (HP:0010459)3.31136749
12Abnormal mitochondria in muscle tissue (HP:0008316)3.19059243
13Acute encephalopathy (HP:0006846)3.14407910
14Medial flaring of the eyebrow (HP:0010747)3.12663471
15Mitochondrial inheritance (HP:0001427)3.11996556
16Rib fusion (HP:0000902)3.06075314
17Macrocytic anemia (HP:0001972)3.03168296
18Progressive macrocephaly (HP:0004481)2.96064892
193-Methylglutaconic aciduria (HP:0003535)2.88852895
20Sclerocornea (HP:0000647)2.88450876
21Abnormality of the renal medulla (HP:0100957)2.82547705
22Increased CSF lactate (HP:0002490)2.81674002
23Abnormal number of erythroid precursors (HP:0012131)2.75467066
24Abnormal rod and cone electroretinograms (HP:0008323)2.69284519
25Hyperglycinemia (HP:0002154)2.69015072
26Pendular nystagmus (HP:0012043)2.68118185
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.67284330
28Asplenia (HP:0001746)2.54947570
29Congenital, generalized hypertrichosis (HP:0004540)2.54589939
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.53936999
31Abolished electroretinogram (ERG) (HP:0000550)2.51251364
32Bile duct proliferation (HP:0001408)2.50928906
33Abnormal biliary tract physiology (HP:0012439)2.50928906
34Cystic liver disease (HP:0006706)2.49167095
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.48805572
36Pallor (HP:0000980)2.47675311
37Lipid accumulation in hepatocytes (HP:0006561)2.44754713
38Absent thumb (HP:0009777)2.40801553
39Hepatocellular necrosis (HP:0001404)2.39960333
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.38672286
41Gait imbalance (HP:0002141)2.37217112
42Increased hepatocellular lipid droplets (HP:0006565)2.35766339
43Optic disc pallor (HP:0000543)2.34852732
44Hypoplasia of the pons (HP:0012110)2.34624231
45Type II lissencephaly (HP:0007260)2.30177394
46Congenital primary aphakia (HP:0007707)2.29002560
47Anencephaly (HP:0002323)2.26187584
48Optic nerve hypoplasia (HP:0000609)2.25334873
49Adrenal hypoplasia (HP:0000835)2.25209471
50Absent septum pellucidum (HP:0001331)2.23335666
51Nephrogenic diabetes insipidus (HP:0009806)2.23064461
52IgG deficiency (HP:0004315)2.21610010
53Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21220709
54Stenosis of the external auditory canal (HP:0000402)2.18899271
55Abnormality of the pons (HP:0007361)2.12224462
56Agitation (HP:0000713)2.11572327
57Decreased central vision (HP:0007663)2.10607162
58Renal Fanconi syndrome (HP:0001994)2.06996815
59Chronic hepatic failure (HP:0100626)2.06844593
60Concave nail (HP:0001598)2.06653531
61Male pseudohermaphroditism (HP:0000037)2.03763366
62Maternal diabetes (HP:0009800)2.02679641
63Hypoplasia of the ulna (HP:0003022)2.00367329
64Stomatitis (HP:0010280)1.99841944
65Abnormal respiratory motile cilium physiology (HP:0012261)1.99417024
66Cerebral edema (HP:0002181)1.98902033
67Postaxial foot polydactyly (HP:0001830)1.97276346
68Congenital hepatic fibrosis (HP:0002612)1.95186919
69Growth hormone deficiency (HP:0000824)1.94879008
70Hypoplasia of the radius (HP:0002984)1.94416171
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.93994760
72Hepatic necrosis (HP:0002605)1.93055915
73Vaginal atresia (HP:0000148)1.91287257
74Limb dystonia (HP:0002451)1.89795349
75Keratoconus (HP:0000563)1.87018492
76Increased corneal curvature (HP:0100692)1.87018492
77Myokymia (HP:0002411)1.86227000
78Abnormality of the renal cortex (HP:0011035)1.86096088
79Absent/shortened dynein arms (HP:0200106)1.86047848
80Dynein arm defect of respiratory motile cilia (HP:0012255)1.86047848
81Enlarged kidneys (HP:0000105)1.84928427
82Genital tract atresia (HP:0001827)1.84685195
83Facial hemangioma (HP:0000329)1.84269711
84Tubular atrophy (HP:0000092)1.83108117
85Abnormality of the proximal phalanges of the hand (HP:0009834)1.81570792
86Postaxial hand polydactyly (HP:0001162)1.81546412
87Hypogonadotrophic hypogonadism (HP:0000044)1.79293935
88Abdominal situs inversus (HP:0003363)1.79163264
89Abnormality of abdominal situs (HP:0011620)1.79163264
90Anophthalmia (HP:0000528)1.78461876
91Increased intramyocellular lipid droplets (HP:0012240)1.78267618
92Abnormality of the septum pellucidum (HP:0007375)1.77785694
93Forearm undergrowth (HP:0009821)1.77465067
94Aplasia/Hypoplasia of the ulna (HP:0006495)1.77315157
95Thyroid-stimulating hormone excess (HP:0002925)1.76182758
96Abnormality of the middle phalanges of the toes (HP:0010183)1.75483551
97Abnormality of the phalanges of the 5th finger (HP:0004213)1.73237881
98Brittle hair (HP:0002299)1.73021543
99Abnormal ciliary motility (HP:0012262)1.72688291
100Abnormality of the labia minora (HP:0012880)1.71659214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.60702962
2WNK43.34094294
3TXK3.17812140
4ZAK2.81442722
5CDK192.74185770
6ADRBK22.73021403
7TLK12.68775314
8GRK12.64862002
9WNK32.31489954
10NUAK12.24607895
11TESK22.24396655
12DYRK22.05727128
13PINK11.90833555
14PIK3CA1.82018477
15NME11.76731976
16OXSR11.74685782
17MUSK1.62762416
18STK391.55626827
19TAOK31.55568649
20BMPR1B1.49070988
21FRK1.48614101
22CASK1.42549613
23EPHA41.27060503
24CDC71.22300251
25MAP2K21.20340339
26ARAF1.15133574
27BCKDK1.13874047
28VRK21.11250504
29LRRK21.09990149
30VRK11.07207710
31INSRR1.06087988
32NTRK31.05381484
33TIE11.02614978
34MAP2K71.01456975
35WNK10.98649592
36PIM20.98288231
37MAP3K40.96293473
38IKBKB0.96249158
39MARK30.96086727
40PRKCG0.94436781
41NTRK20.91795415
42PLK40.86331286
43TYRO30.85820079
44RPS6KA50.77830253
45STK110.77577026
46RPS6KA60.74762996
47MAPK150.74513276
48ITK0.73927271
49MAP4K20.71368501
50BRAF0.69459637
51PAK30.69390343
52PRKCQ0.69250505
53PASK0.68843302
54MINK10.68289159
55ADRBK10.66667825
56CSNK1G20.65773521
57PRKACA0.65430769
58MAPK130.63104508
59SIK20.62050949
60MAP3K110.61840428
61PRKCI0.60906590
62PLK20.60537740
63MAP3K90.60291593
64IKBKE0.60234317
65CAMK10.59742607
66PHKG10.56412745
67PHKG20.56412745
68TNIK0.54806840
69RPS6KC10.54473781
70RPS6KL10.54473781
71TRIM280.52728856
72DAPK30.51988142
73NEK10.51715407
74CSNK2A20.50767734
75BCR0.49878974
76PRKCE0.49861777
77TEC0.49072776
78AURKB0.48034273
79BMPR20.47284813
80OBSCN0.47204124
81MARK10.45207268
82CSNK1E0.44510414
83PRKCZ0.42270740
84KDR0.42131781
85CSNK1G30.41132123
86CSNK1A10.40593861
87LCK0.40048263
88PRKCH0.39557755
89CHUK0.38698189
90CDK50.37400382
91PRKCD0.37130783
92CSNK1A1L0.36931995
93PLK10.36735287
94PIM10.36476656
95LYN0.35053210
96DYRK1A0.34864921
97GRK50.34776081
98CAMK1D0.34736096
99PRKCA0.34703840
100CHEK20.34282297

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.53574568
2Oxidative phosphorylation_Homo sapiens_hsa001904.22828333
3Parkinsons disease_Homo sapiens_hsa050123.50919424
4Asthma_Homo sapiens_hsa053103.00244092
5Cardiac muscle contraction_Homo sapiens_hsa042602.57190117
6Alzheimers disease_Homo sapiens_hsa050102.41772748
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.40444086
8Huntingtons disease_Homo sapiens_hsa050162.33312825
9Protein export_Homo sapiens_hsa030602.21312240
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.18506193
11Phototransduction_Homo sapiens_hsa047442.05247573
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99915530
13Allograft rejection_Homo sapiens_hsa053301.99154062
14Autoimmune thyroid disease_Homo sapiens_hsa053201.92390188
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89437272
16Linoleic acid metabolism_Homo sapiens_hsa005911.78428526
17RNA polymerase_Homo sapiens_hsa030201.77674460
18Homologous recombination_Homo sapiens_hsa034401.66117384
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65541665
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61993800
21Proteasome_Homo sapiens_hsa030501.60110065
22Basal transcription factors_Homo sapiens_hsa030221.57286644
23Nicotine addiction_Homo sapiens_hsa050331.55357049
24Graft-versus-host disease_Homo sapiens_hsa053321.48515833
25Type I diabetes mellitus_Homo sapiens_hsa049401.45014124
26RNA degradation_Homo sapiens_hsa030181.38259571
27Nitrogen metabolism_Homo sapiens_hsa009101.36573411
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35315763
29One carbon pool by folate_Homo sapiens_hsa006701.27684247
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27570406
31Primary immunodeficiency_Homo sapiens_hsa053401.18855959
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13851786
33Butanoate metabolism_Homo sapiens_hsa006501.04651774
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.00767444
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98635322
36Chemical carcinogenesis_Homo sapiens_hsa052040.98545389
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97867071
38Maturity onset diabetes of the young_Homo sapiens_hsa049500.95476654
39Propanoate metabolism_Homo sapiens_hsa006400.92576715
40Morphine addiction_Homo sapiens_hsa050320.92068393
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85961713
42Caffeine metabolism_Homo sapiens_hsa002320.85604626
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84437640
44Hedgehog signaling pathway_Homo sapiens_hsa043400.83903913
45Mismatch repair_Homo sapiens_hsa034300.81006272
46Arachidonic acid metabolism_Homo sapiens_hsa005900.80873115
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80266933
48Peroxisome_Homo sapiens_hsa041460.78709143
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78154990
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76539078
51Rheumatoid arthritis_Homo sapiens_hsa053230.75645810
52Sulfur relay system_Homo sapiens_hsa041220.75600377
53Tryptophan metabolism_Homo sapiens_hsa003800.75553228
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74560404
55Olfactory transduction_Homo sapiens_hsa047400.73107326
56Pyrimidine metabolism_Homo sapiens_hsa002400.72837784
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72087485
58Fanconi anemia pathway_Homo sapiens_hsa034600.71498073
59Regulation of autophagy_Homo sapiens_hsa041400.70054659
60Systemic lupus erythematosus_Homo sapiens_hsa053220.68903226
61Nucleotide excision repair_Homo sapiens_hsa034200.67882357
62Retinol metabolism_Homo sapiens_hsa008300.66574129
63Serotonergic synapse_Homo sapiens_hsa047260.65003058
64Fat digestion and absorption_Homo sapiens_hsa049750.64141133
65Glutamatergic synapse_Homo sapiens_hsa047240.63829249
66Fatty acid degradation_Homo sapiens_hsa000710.60227719
67Basal cell carcinoma_Homo sapiens_hsa052170.59880581
68Purine metabolism_Homo sapiens_hsa002300.57243600
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.57233468
70Insulin secretion_Homo sapiens_hsa049110.55181216
71Metabolic pathways_Homo sapiens_hsa011000.54888144
72GABAergic synapse_Homo sapiens_hsa047270.54332748
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52481113
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49163491
75Hematopoietic cell lineage_Homo sapiens_hsa046400.49041775
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47534964
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47032797
78Ether lipid metabolism_Homo sapiens_hsa005650.46891935
79Fatty acid biosynthesis_Homo sapiens_hsa000610.44491501
80Folate biosynthesis_Homo sapiens_hsa007900.42261053
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42234414
82Collecting duct acid secretion_Homo sapiens_hsa049660.42051604
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39397934
84Vitamin digestion and absorption_Homo sapiens_hsa049770.38826363
85Fatty acid metabolism_Homo sapiens_hsa012120.37950442
86Cholinergic synapse_Homo sapiens_hsa047250.36556966
87Circadian entrainment_Homo sapiens_hsa047130.34688057
88Ovarian steroidogenesis_Homo sapiens_hsa049130.32804357
89Cocaine addiction_Homo sapiens_hsa050300.32183684
90Mineral absorption_Homo sapiens_hsa049780.30624261
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.29958522
92Taste transduction_Homo sapiens_hsa047420.29391691
93RNA transport_Homo sapiens_hsa030130.26593650
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26164702
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23503117
96T cell receptor signaling pathway_Homo sapiens_hsa046600.22376421
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22182622
98African trypanosomiasis_Homo sapiens_hsa051430.21481482
99Salivary secretion_Homo sapiens_hsa049700.20767626
100Alcoholism_Homo sapiens_hsa050340.20623702

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