ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cilium movement (GO:0003352)	4.99053858
2	gonadal mesoderm development (GO:0007506)	4.93299798
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.81124909
4	nonmotile primary cilium assembly (GO:0035058)	4.64063753
5	axoneme assembly (GO:0035082)	4.41825732
6	epithelial cilium movement (GO:0003351)	4.08592663
7	regulation of microtubule-based movement (GO:0060632)	3.98571533
8	cilium movement (GO:0003341)	3.92424116
9	photoreceptor cell maintenance (GO:0045494)	3.74903350
10	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.73344892
11	cellular ketone body metabolic process (GO:0046950)	3.71909014
12	ovulation cycle (GO:0042698)	3.61137568
13	neural tube formation (GO:0001841)	3.59343903
14	preassembly of GPI anchor in ER membrane (GO:0016254)	3.49821814
15	cilium or flagellum-dependent cell motility (GO:0001539)	3.49751971
16	axonemal dynein complex assembly (GO:0070286)	3.47337296
17	response to pheromone (GO:0019236)	3.46884422
18	somite development (GO:0061053)	3.45176159
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.43002228
20	ATP synthesis coupled proton transport (GO:0015986)	3.43002228
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.42454921
22	behavioral response to nicotine (GO:0035095)	3.39800900
23	ketone body metabolic process (GO:1902224)	3.30257602
24	DNA deamination (GO:0045006)	3.25874325
25	retinal cone cell development (GO:0046549)	3.24793219
26	positive regulation of neurological system process (GO:0031646)	3.20975890
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.20597923
28	retinal rod cell development (GO:0046548)	3.18753490
29	regulation of transmission of nerve impulse (GO:0051969)	3.18201769
30	photoreceptor cell development (GO:0042461)	3.15486337
31	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.15484012
32	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.15484012
33	signal peptide processing (GO:0006465)	3.14582071
34	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.14341131
35	retinal ganglion cell axon guidance (GO:0031290)	3.13184457
36	translational termination (GO:0006415)	3.11134945
37	ribosomal small subunit assembly (GO:0000028)	3.07484785
38	GTP biosynthetic process (GO:0006183)	3.07418822
39	cilium organization (GO:0044782)	3.04740890
40	viral transcription (GO:0019083)	3.02824550
41	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.99173167
42	cilium assembly (GO:0042384)	2.97312642
43	protein complex biogenesis (GO:0070271)	2.94552866
44	base-excision repair, AP site formation (GO:0006285)	2.93920604
45	electron transport chain (GO:0022900)	2.93123803
46	respiratory electron transport chain (GO:0022904)	2.92460632
47	exogenous drug catabolic process (GO:0042738)	2.91883969
48	motile cilium assembly (GO:0044458)	2.90876585
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.86355396
50	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.86355396
51	NADH dehydrogenase complex assembly (GO:0010257)	2.86355396
52	axonal fasciculation (GO:0007413)	2.86089822
53	mannosylation (GO:0097502)	2.85069932
54	chaperone-mediated protein transport (GO:0072321)	2.82886985
55	cotranslational protein targeting to membrane (GO:0006613)	2.80112892
56	protein polyglutamylation (GO:0018095)	2.79260493
57	dendritic spine morphogenesis (GO:0060997)	2.77493512
58	cilium morphogenesis (GO:0060271)	2.77438677
59	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.77330015
60	DNA demethylation (GO:0080111)	2.75722079
61	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.74683492
62	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.74542031
63	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.72868745
64	C-terminal protein amino acid modification (GO:0018410)	2.71779249
65	mechanosensory behavior (GO:0007638)	2.68567173
66	tryptophan catabolic process (GO:0006569)	2.68556906
67	indole-containing compound catabolic process (GO:0042436)	2.68556906
68	indolalkylamine catabolic process (GO:0046218)	2.68556906
69	C-terminal protein lipidation (GO:0006501)	2.68041455
70	protein targeting to ER (GO:0045047)	2.67820309
71	kynurenine metabolic process (GO:0070189)	2.65875442
72	eye photoreceptor cell development (GO:0042462)	2.65766168
73	UTP biosynthetic process (GO:0006228)	2.65285616
74	cytochrome complex assembly (GO:0017004)	2.64605464
75	respiratory chain complex IV assembly (GO:0008535)	2.63990420
76	oxidative demethylation (GO:0070989)	2.63117826
77	short-term memory (GO:0007614)	2.62092765
78	cardiovascular system development (GO:0072358)	2.59788685
79	hydrogen ion transmembrane transport (GO:1902600)	2.59431495
80	hydrogen transport (GO:0006818)	2.58451245
81	negative regulation of multicellular organism growth (GO:0040015)	2.57953205
82	proton transport (GO:0015992)	2.57794465
83	lysine catabolic process (GO:0006554)	2.56711366
84	lysine metabolic process (GO:0006553)	2.56711366
85	synaptic transmission, glutamatergic (GO:0035249)	2.55896542
86	aldehyde catabolic process (GO:0046185)	2.55620422
87	protein prenylation (GO:0018342)	2.55218228
88	prenylation (GO:0097354)	2.55218228
89	L-fucose catabolic process (GO:0042355)	2.54710571
90	fucose catabolic process (GO:0019317)	2.54710571
91	L-fucose metabolic process (GO:0042354)	2.54710571
92	one-carbon compound transport (GO:0019755)	2.53987976
93	protein localization to endoplasmic reticulum (GO:0070972)	2.52973871
94	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.52093442
95	mitochondrial respiratory chain complex assembly (GO:0033108)	2.51286884
96	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.51044852
97	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.50675961
98	intraciliary transport (GO:0042073)	2.50461796
99	negative regulation of appetite (GO:0032099)	2.50200086
100	negative regulation of response to food (GO:0032096)	2.50200086

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.89386491
2	VDR_22108803_ChIP-Seq_LS180_Human	3.74264414
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.50126643
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93989950
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.77907794
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.67466326
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.59768222
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.55179698
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.51445578
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.50062901
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.49755551
12	FUS_26573619_Chip-Seq_HEK293_Human	2.19177553
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.08394651
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.06548532
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05493896
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.04632280
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.01374599
18	EWS_26573619_Chip-Seq_HEK293_Human	1.98355599
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.96712730
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.95969834
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.94377257
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.80054279
23	P300_19829295_ChIP-Seq_ESCs_Human	1.78243867
24	AR_21572438_ChIP-Seq_LNCaP_Human	1.65531937
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.64616565
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64351101
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.62603503
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.61197661
29	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.60392376
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.54853120
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51378835
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.46576706
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45563528
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.45563528
35	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.42284105
36	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.39521323
37	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.39106397
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38799890
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.38679561
40	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.35532350
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35340231
42	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.35224266
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.34331967
44	TCF4_22108803_ChIP-Seq_LS180_Human	1.32425050
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32134216
46	STAT3_23295773_ChIP-Seq_U87_Human	1.30356981
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29818873
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29818873
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28108206
50	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.27189688
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23982510
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23422549
53	REST_21632747_ChIP-Seq_MESCs_Mouse	1.23293017
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.22893284
55	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.22538925
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22325215
57	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.22066844
58	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.21538594
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21171178
60	TCF4_23295773_ChIP-Seq_U87_Human	1.20522230
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20479454
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.19112733
63	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.15711456
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14541739
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13294683
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13141101
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.13141101
68	AR_25329375_ChIP-Seq_VCAP_Human	1.10929012
69	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.09539050
70	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.09240366
71	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09175416
72	NCOR_22424771_ChIP-Seq_293T_Human	1.08781086
73	AR_20517297_ChIP-Seq_VCAP_Human	1.07304088
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06723721
75	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.04206070
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04108811
77	VDR_23849224_ChIP-Seq_CD4+_Human	1.04036766
78	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03943673
79	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03901081
80	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02713447
81	MYC_18940864_ChIP-ChIP_HL60_Human	1.02288553
82	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.00608029
83	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99400202
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99032283
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.99025944
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.99025944
87	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.98861789
88	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.98071625
89	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.98045802
90	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.97630532
91	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96663660
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95868964
93	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95581858
94	CDX2_22108803_ChIP-Seq_LS180_Human	0.95568688
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93715795
96	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.92805205
97	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.91883680
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91789055
99	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.91171535
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.89800336

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	4.50180481
2	MP0002102_abnormal_ear_morphology	3.60096224
3	MP0008877_abnormal_DNA_methylation	3.44585124
4	MP0002653_abnormal_ependyma_morphology	3.25319318
5	MP0002736_abnormal_nociception_after	3.08356900
6	MP0005551_abnormal_eye_electrophysiolog	2.51429979
7	MP0001968_abnormal_touch/_nociception	2.49678101
8	MP0000569_abnormal_digit_pigmentation	2.39246654
9	MP0006072_abnormal_retinal_apoptosis	2.34203461
10	MP0004145_abnormal_muscle_electrophysio	2.31220932
11	MP0001984_abnormal_olfaction	2.25335449
12	MP0003283_abnormal_digestive_organ	2.23636394
13	MP0003315_abnormal_perineum_morphology	2.20165075
14	MP0005253_abnormal_eye_physiology	2.12760961
15	MP0003646_muscle_fatigue	2.12534817
16	MP0004142_abnormal_muscle_tone	1.96494715
17	MP0006276_abnormal_autonomic_nervous	1.94510563
18	MP0005423_abnormal_somatic_nervous	1.92856298
19	MP0005075_abnormal_melanosome_morpholog	1.92753486
20	MP0002272_abnormal_nervous_system	1.82151909
21	MP0005408_hypopigmentation	1.71820043
22	MP0009046_muscle_twitch	1.71464957
23	MP0003880_abnormal_central_pattern	1.63818886
24	MP0005187_abnormal_penis_morphology	1.59694523
25	MP0003136_yellow_coat_color	1.52392447
26	MP0001970_abnormal_pain_threshold	1.52290866
27	MP0002837_dystrophic_cardiac_calcinosis	1.52203125
28	MP0001486_abnormal_startle_reflex	1.52160010
29	MP0009053_abnormal_anal_canal	1.51076723
30	MP0004742_abnormal_vestibular_system	1.48905849
31	MP0000516_abnormal_urinary_system	1.48645913
32	MP0005367_renal/urinary_system_phenotyp	1.48645913
33	MP0000778_abnormal_nervous_system	1.46410882
34	MP0002733_abnormal_thermal_nociception	1.44994921
35	MP0009745_abnormal_behavioral_response	1.44781270
36	MP0008872_abnormal_physiological_respon	1.44618226
37	MP0008875_abnormal_xenobiotic_pharmacok	1.41134150
38	MP0005167_abnormal_blood-brain_barrier	1.38984699
39	MP0001293_anophthalmia	1.34024485
40	MP0009379_abnormal_foot_pigmentation	1.32443191
41	MP0002234_abnormal_pharynx_morphology	1.28823269
42	MP0006292_abnormal_olfactory_placode	1.28618725
43	MP0004133_heterotaxia	1.26936111
44	MP0004043_abnormal_pH_regulation	1.26617240
45	MP0002184_abnormal_innervation	1.26455114
46	MP0002751_abnormal_autonomic_nervous	1.25894750
47	MP0000427_abnormal_hair_cycle	1.24084152
48	MP0002557_abnormal_social/conspecific_i	1.23449412
49	MP0002734_abnormal_mechanical_nocicepti	1.22584253
50	MP0005195_abnormal_posterior_eye	1.21491398
51	MP0002909_abnormal_adrenal_gland	1.21428049
52	MP0002938_white_spotting	1.20723858
53	MP0003195_calcinosis	1.19804878
54	MP0003252_abnormal_bile_duct	1.19532116
55	MP0008058_abnormal_DNA_repair	1.18878687
56	MP0005083_abnormal_biliary_tract	1.18791003
57	MP0004019_abnormal_vitamin_homeostasis	1.13833767
58	MP0003119_abnormal_digestive_system	1.13443467
59	MP0002095_abnormal_skin_pigmentation	1.13323647
60	MP0005084_abnormal_gallbladder_morpholo	1.11714672
61	MP0003122_maternal_imprinting	1.11547426
62	MP0002064_seizures	1.11256373
63	MP0003121_genomic_imprinting	1.09703100
64	MP0000955_abnormal_spinal_cord	1.06867222
65	MP0005085_abnormal_gallbladder_physiolo	1.06754919
66	MP0005645_abnormal_hypothalamus_physiol	1.06539903
67	MP0005389_reproductive_system_phenotype	1.06414359
68	MP0008995_early_reproductive_senescence	1.06011192
69	MP0002572_abnormal_emotion/affect_behav	1.02515957
70	MP0001963_abnormal_hearing_physiology	1.02059880
71	MP0006035_abnormal_mitochondrial_morpho	1.01755677
72	MP0003787_abnormal_imprinting	0.98948259
73	MP0001440_abnormal_grooming_behavior	0.98370958
74	MP0005646_abnormal_pituitary_gland	0.98326960
75	MP0005391_vision/eye_phenotype	0.97495879
76	MP0002735_abnormal_chemical_nociception	0.95991896
77	MP0002277_abnormal_respiratory_mucosa	0.95693013
78	MP0001485_abnormal_pinna_reflex	0.93914646
79	MP0004215_abnormal_myocardial_fiber	0.93226564
80	MP0000538_abnormal_urinary_bladder	0.91885472
81	MP0002752_abnormal_somatic_nervous	0.91135749
82	MP0002160_abnormal_reproductive_system	0.91057015
83	MP0002067_abnormal_sensory_capabilities	0.90435625
84	MP0008775_abnormal_heart_ventricle	0.89313655
85	MP0005410_abnormal_fertilization	0.88638630
86	MP0001905_abnormal_dopamine_level	0.88346557
87	MP0002229_neurodegeneration	0.86290526
88	MP0002928_abnormal_bile_duct	0.84468099
89	MP0002254_reproductive_system_inflammat	0.84378202
90	MP0006036_abnormal_mitochondrial_physio	0.82024433
91	MP0003937_abnormal_limbs/digits/tail_de	0.81184836
92	MP0004885_abnormal_endolymph	0.80327189
93	MP0003635_abnormal_synaptic_transmissio	0.80166402
94	MP0002063_abnormal_learning/memory/cond	0.78310255
95	MP0009250_abnormal_appendicular_skeleto	0.77995183
96	MP0001919_abnormal_reproductive_system	0.76796445
97	MP0000049_abnormal_middle_ear	0.73573451
98	MP0003698_abnormal_male_reproductive	0.72510128
99	MP0002638_abnormal_pupillary_reflex	0.72478292
100	MP0000383_abnormal_hair_follicle	0.70318780

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	4.37920482
2	Gait imbalance (HP:0002141)	4.27392700
3	Pancreatic fibrosis (HP:0100732)	4.24565483
4	Congenital primary aphakia (HP:0007707)	4.19478324
5	Pancreatic cysts (HP:0001737)	3.83165275
6	Pendular nystagmus (HP:0012043)	3.79865449
7	Abnormality of midbrain morphology (HP:0002418)	3.70650669
8	Molar tooth sign on MRI (HP:0002419)	3.70650669
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.63577401
10	Absent/shortened dynein arms (HP:0200106)	3.63577401
11	Nephrogenic diabetes insipidus (HP:0009806)	3.62974428
12	True hermaphroditism (HP:0010459)	3.56691435
13	Type II lissencephaly (HP:0007260)	3.50298552
14	Acute necrotizing encephalopathy (HP:0006965)	3.49310563
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.35825103
16	Abnormal respiratory motile cilium morphology (HP:0005938)	3.34206148
17	Abnormal respiratory epithelium morphology (HP:0012253)	3.34206148
18	Poor coordination (HP:0002370)	3.25951514
19	Abnormal ciliary motility (HP:0012262)	3.22045061
20	Abnormal rod and cone electroretinograms (HP:0008323)	3.20386204
21	Chronic hepatic failure (HP:0100626)	3.16258206
22	Genital tract atresia (HP:0001827)	3.14698234
23	Vaginal atresia (HP:0000148)	3.13807115
24	Abnormal mitochondria in muscle tissue (HP:0008316)	3.13531435
25	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.13364270
26	Abnormal respiratory motile cilium physiology (HP:0012261)	3.09699179
27	Acute encephalopathy (HP:0006846)	2.98414420
28	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.93156447
29	3-Methylglutaconic aciduria (HP:0003535)	2.92356474
30	Mitochondrial inheritance (HP:0001427)	2.91045328
31	Supernumerary spleens (HP:0009799)	2.90152528
32	Increased CSF lactate (HP:0002490)	2.86636906
33	Progressive macrocephaly (HP:0004481)	2.84865534
34	Asplenia (HP:0001746)	2.79172987
35	Hepatocellular necrosis (HP:0001404)	2.75693101
36	Optic disc pallor (HP:0000543)	2.68055376
37	Reticulocytopenia (HP:0001896)	2.59979308
38	Congenital stationary night blindness (HP:0007642)	2.58498687
39	Cystic liver disease (HP:0006706)	2.51458658
40	Bilateral microphthalmos (HP:0007633)	2.48495071
41	Nephronophthisis (HP:0000090)	2.47487623
42	Large for gestational age (HP:0001520)	2.45650688
43	Oligodactyly (hands) (HP:0001180)	2.45464367
44	Keratoconus (HP:0000563)	2.44733081
45	Increased corneal curvature (HP:0100692)	2.44733081
46	Sclerocornea (HP:0000647)	2.41451735
47	Hypomagnesemia (HP:0002917)	2.40808838
48	Cerebellar dysplasia (HP:0007033)	2.39239883
49	Bony spicule pigmentary retinopathy (HP:0007737)	2.37152774
50	Occipital encephalocele (HP:0002085)	2.33217379
51	Postaxial hand polydactyly (HP:0001162)	2.32454424
52	Abnormality of the renal cortex (HP:0011035)	2.29942068
53	Male pseudohermaphroditism (HP:0000037)	2.24752222
54	Abnormality of the renal medulla (HP:0100957)	2.24567643
55	Hepatic necrosis (HP:0002605)	2.23538481
56	Rhinitis (HP:0012384)	2.22942465
57	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16936838
58	Attenuation of retinal blood vessels (HP:0007843)	2.16591564
59	Polydipsia (HP:0001959)	2.16344124
60	Abnormal drinking behavior (HP:0030082)	2.16344124
61	Left ventricular hypertrophy (HP:0001712)	2.13877427
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.13160564
63	Decreased central vision (HP:0007663)	2.12052929
64	Chronic bronchitis (HP:0004469)	2.11410998
65	Aplasia/Hypoplasia of the lens (HP:0008063)	2.08966604
66	Abnormal biliary tract physiology (HP:0012439)	2.07937278
67	Bile duct proliferation (HP:0001408)	2.07937278
68	Postaxial foot polydactyly (HP:0001830)	2.06655751
69	Broad foot (HP:0001769)	2.02519097
70	Cerebral edema (HP:0002181)	2.01165925
71	Lissencephaly (HP:0001339)	2.00654462
72	Stomatitis (HP:0010280)	1.99839720
73	Anophthalmia (HP:0000528)	1.99089112
74	Abnormality of cells of the erythroid lineage (HP:0012130)	1.95673305
75	Astigmatism (HP:0000483)	1.95057762
76	Myokymia (HP:0002411)	1.94617770
77	Anencephaly (HP:0002323)	1.93748067
78	Polyuria (HP:0000103)	1.92381058
79	Abnormality of T cell physiology (HP:0011840)	1.87976165
80	Preaxial hand polydactyly (HP:0001177)	1.87686101
81	Bronchiectasis (HP:0002110)	1.87654109
82	Abolished electroretinogram (ERG) (HP:0000550)	1.87199784
83	Ketoacidosis (HP:0001993)	1.85912235
84	Respiratory failure (HP:0002878)	1.85738249
85	Stenosis of the external auditory canal (HP:0000402)	1.85161594
86	Decreased testicular size (HP:0008734)	1.84831827
87	Congenital hepatic fibrosis (HP:0002612)	1.84413119
88	Type 2 muscle fiber atrophy (HP:0003554)	1.84390548
89	Congenital, generalized hypertrichosis (HP:0004540)	1.84111707
90	Retinal dysplasia (HP:0007973)	1.83353463
91	Optic nerve coloboma (HP:0000588)	1.82029448
92	Specific learning disability (HP:0001328)	1.81955979
93	Chorioretinal atrophy (HP:0000533)	1.79290806
94	Constricted visual fields (HP:0001133)	1.78910316
95	CNS demyelination (HP:0007305)	1.78402988
96	Abnormality of the labia minora (HP:0012880)	1.77200007
97	Pachygyria (HP:0001302)	1.76860411
98	Anterior segment dysgenesis (HP:0007700)	1.75472132
99	Renal cortical cysts (HP:0000803)	1.74023524
100	Esotropia (HP:0000565)	1.69958492

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.97074224
2	MAP4K2	4.05917553
3	WNK4	3.15914354
4	PDK2	2.80518438
5	STK38L	2.42627460
6	ADRBK2	2.09411942
7	STK39	2.09153706
8	MKNK2	2.05269862
9	GRK1	1.69738317
10	STK16	1.69273296
11	DYRK2	1.66522138
12	OXSR1	1.66232440
13	CAMKK2	1.65470946
14	BCKDK	1.60093925
15	CSNK1G2	1.58197593
16	CSNK1G1	1.55306823
17	CSNK1G3	1.53082053
18	DAPK2	1.52754779
19	MAP3K12	1.48713842
20	CASK	1.42585061
21	CSNK1A1L	1.36597607
22	TXK	1.35025808
23	MAP3K4	1.34865094
24	WNK3	1.32956325
25	PAK3	1.31139691
26	NUAK1	1.25766613
27	NTRK2	1.20572996
28	MAPK13	1.17770465
29	MAP3K9	1.13271250
30	ZAK	1.12935786
31	TNK2	1.10001073
32	MKNK1	1.08309957
33	PRKCG	1.05440894
34	TLK1	1.02846709
35	MAP2K6	1.01179956
36	PASK	1.00777933
37	PRKCQ	0.98372049
38	EPHB2	0.95876391
39	PLK2	0.93822969
40	GRK7	0.93037403
41	OBSCN	0.92107158
42	PINK1	0.91897950
43	MAP3K11	0.90848611
44	EPHA4	0.88885669
45	TYRO3	0.88469471
46	ADRBK1	0.88239359
47	PHKG1	0.85956371
48	PHKG2	0.85956371
49	PRKCI	0.84964398
50	CAMKK1	0.83526285
51	NME1	0.83323449
52	VRK2	0.79202488
53	BRSK2	0.76439632
54	ERBB2	0.75077871
55	TIE1	0.73926917
56	INSRR	0.73299015
57	KSR1	0.72108856
58	IKBKB	0.70730664
59	TNIK	0.69374363
60	PRKCE	0.69174555
61	NEK6	0.68052208
62	PRKACA	0.66415427
63	RPS6KA5	0.66043507
64	NLK	0.65097851
65	FGFR2	0.63973285
66	MARK1	0.63163375
67	VRK1	0.61326859
68	CAMK1	0.59828883
69	PNCK	0.58814751
70	CAMK4	0.58248934
71	MAP2K7	0.57773263
72	PRKCH	0.57456894
73	SRPK1	0.55780127
74	CAMK2A	0.54590821
75	EIF2AK1	0.52042553
76	RPS6KA6	0.51528085
77	BMPR1B	0.50235541
78	CSNK1A1	0.47519365
79	PIK3CA	0.46402114
80	SGK223	0.43873644
81	SGK494	0.43873644
82	CHUK	0.43206462
83	PRKCA	0.42438776
84	PTK2B	0.42356942
85	LYN	0.41754605
86	PRKCZ	0.41409692
87	STK11	0.39622149
88	BRSK1	0.39554862
89	CDK19	0.39041290
90	ROCK1	0.38789284
91	GSK3A	0.36794293
92	FER	0.36694819
93	IRAK1	0.35514634
94	CAMK2D	0.35000387
95	SGK2	0.33713036
96	SGK1	0.33476710
97	DAPK3	0.33305825
98	CSNK1E	0.32862660
99	ATR	0.32342915
100	TAOK1	0.32317086

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.38294208
2	Ribosome_Homo sapiens_hsa03010	3.09207132
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.95736570
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.94019703
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.89573526
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.64326569
7	Parkinsons disease_Homo sapiens_hsa05012	2.54003570
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.47266038
9	Caffeine metabolism_Homo sapiens_hsa00232	2.22273129
10	Basal transcription factors_Homo sapiens_hsa03022	2.15758103
11	Protein export_Homo sapiens_hsa03060	2.09002640
12	Proteasome_Homo sapiens_hsa03050	2.07300820
13	Huntingtons disease_Homo sapiens_hsa05016	2.01548292
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.98911988
15	Nicotine addiction_Homo sapiens_hsa05033	1.86870761
16	Alzheimers disease_Homo sapiens_hsa05010	1.85336453
17	RNA polymerase_Homo sapiens_hsa03020	1.84307768
18	Homologous recombination_Homo sapiens_hsa03440	1.79424299
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.77208251
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.74428303
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.74416473
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.68962586
23	Butanoate metabolism_Homo sapiens_hsa00650	1.66271140
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.51700342
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.48544722
26	Propanoate metabolism_Homo sapiens_hsa00640	1.45743923
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.39247008
28	Phototransduction_Homo sapiens_hsa04744	1.34013438
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.33028503
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.32816763
31	Peroxisome_Homo sapiens_hsa04146	1.31857624
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.20773975
33	Asthma_Homo sapiens_hsa05310	1.17467407
34	Insulin secretion_Homo sapiens_hsa04911	1.16914195
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.14219655
36	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.11807619
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.10773174
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.09370244
39	Olfactory transduction_Homo sapiens_hsa04740	1.03560390
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03358215
41	Selenocompound metabolism_Homo sapiens_hsa00450	1.03079562
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02738709
43	RNA degradation_Homo sapiens_hsa03018	1.02032979
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.00700159
45	Fat digestion and absorption_Homo sapiens_hsa04975	0.99139282
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.95555812
47	Mineral absorption_Homo sapiens_hsa04978	0.94946575
48	Primary immunodeficiency_Homo sapiens_hsa05340	0.93674473
49	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.90987317
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90255657
51	Taste transduction_Homo sapiens_hsa04742	0.89179733
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87121895
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84979892
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.82295131
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81051273
56	Morphine addiction_Homo sapiens_hsa05032	0.78461412
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.78404581
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75770389
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75576636
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73876438
61	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.72585722
62	Glutamatergic synapse_Homo sapiens_hsa04724	0.72400254
63	Fatty acid degradation_Homo sapiens_hsa00071	0.70899287
64	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68248556
65	Sulfur metabolism_Homo sapiens_hsa00920	0.68203556
66	Histidine metabolism_Homo sapiens_hsa00340	0.67919442
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65090205
68	GABAergic synapse_Homo sapiens_hsa04727	0.64904117
69	Fanconi anemia pathway_Homo sapiens_hsa03460	0.63927232
70	Base excision repair_Homo sapiens_hsa03410	0.61061681
71	ABC transporters_Homo sapiens_hsa02010	0.60827414
72	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.60116817
73	Circadian entrainment_Homo sapiens_hsa04713	0.59881927
74	Metabolic pathways_Homo sapiens_hsa01100	0.59079809
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57062088
76	Basal cell carcinoma_Homo sapiens_hsa05217	0.56885028
77	Nucleotide excision repair_Homo sapiens_hsa03420	0.55354334
78	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.55079405
79	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.54868301
80	Sphingolipid metabolism_Homo sapiens_hsa00600	0.54720220
81	Salivary secretion_Homo sapiens_hsa04970	0.53907791
82	Regulation of autophagy_Homo sapiens_hsa04140	0.53029323
83	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53007643
84	Lysine degradation_Homo sapiens_hsa00310	0.52448277
85	Retinol metabolism_Homo sapiens_hsa00830	0.51760193
86	Purine metabolism_Homo sapiens_hsa00230	0.49520153
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46358066
88	Allograft rejection_Homo sapiens_hsa05330	0.46181107
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.45637836
90	Bile secretion_Homo sapiens_hsa04976	0.45592644
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.43921437
92	One carbon pool by folate_Homo sapiens_hsa00670	0.42920342
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41183116
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.39022178
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36768286
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36496782
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.35581631
98	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34602733
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.31238033
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.31207992

RPL21P43

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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