ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.78489133
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.43072331
3	ATP synthesis coupled proton transport (GO:0015986)	4.43072331
4	nonmotile primary cilium assembly (GO:0035058)	4.04039602
5	viral transcription (GO:0019083)	3.94139253
6	serotonin metabolic process (GO:0042428)	3.89552114
7	translational termination (GO:0006415)	3.86799930
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.84657767
9	indolalkylamine metabolic process (GO:0006586)	3.83479729
10	primary amino compound metabolic process (GO:1901160)	3.76877820
11	ribosomal small subunit assembly (GO:0000028)	3.73392523
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.70563526
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.68957061
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.68957061
15	NADH dehydrogenase complex assembly (GO:0010257)	3.68957061
16	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.64643347
17	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.62665258
18	protein complex biogenesis (GO:0070271)	3.60683681
19	cotranslational protein targeting to membrane (GO:0006613)	3.59178656
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.58389855
21	ribosomal large subunit biogenesis (GO:0042273)	3.56359858
22	protein targeting to ER (GO:0045047)	3.54421563
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.48116911
24	activated T cell proliferation (GO:0050798)	3.44764019
25	lactate metabolic process (GO:0006089)	3.44362237
26	indole-containing compound metabolic process (GO:0042430)	3.41228222
27	platelet dense granule organization (GO:0060155)	3.39189734
28	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.38240625
29	protein localization to endoplasmic reticulum (GO:0070972)	3.37912954
30	tryptophan catabolic process (GO:0006569)	3.35953257
31	indole-containing compound catabolic process (GO:0042436)	3.35953257
32	indolalkylamine catabolic process (GO:0046218)	3.35953257
33	negative regulation of T cell differentiation in thymus (GO:0033085)	3.35492962
34	positive regulation of T cell apoptotic process (GO:0070234)	3.30354514
35	negative regulation of mast cell activation (GO:0033004)	3.29597154
36	DNA deamination (GO:0045006)	3.29125093
37	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.24900106
38	substrate-independent telencephalic tangential migration (GO:0021826)	3.24900106
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.22088865
40	protein neddylation (GO:0045116)	3.22068732
41	negative regulation of leukocyte chemotaxis (GO:0002689)	3.21099815
42	translational elongation (GO:0006414)	3.16361897
43	ribonucleoprotein complex disassembly (GO:0032988)	3.10702312
44	electron transport chain (GO:0022900)	3.09622957
45	respiratory electron transport chain (GO:0022904)	3.05752405
46	tryptophan metabolic process (GO:0006568)	3.02960676
47	somite development (GO:0061053)	3.01686741
48	kynurenine metabolic process (GO:0070189)	3.00303220
49	regulation of cilium movement (GO:0003352)	2.99633684
50	ATP biosynthetic process (GO:0006754)	2.99204287
51	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.98985679
52	GTP biosynthetic process (GO:0006183)	2.98293417
53	organelle disassembly (GO:1903008)	2.96082820
54	response to pheromone (GO:0019236)	2.92145112
55	protein-cofactor linkage (GO:0018065)	2.91566946
56	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.91169592
57	anterograde synaptic vesicle transport (GO:0048490)	2.91131566
58	fucose catabolic process (GO:0019317)	2.89932375
59	L-fucose metabolic process (GO:0042354)	2.89932375
60	L-fucose catabolic process (GO:0042355)	2.89932375
61	cell proliferation in forebrain (GO:0021846)	2.87853406
62	chaperone-mediated protein transport (GO:0072321)	2.86051026
63	protein localization to cilium (GO:0061512)	2.82352558
64	regulation of action potential (GO:0098900)	2.80767526
65	cellular protein complex disassembly (GO:0043624)	2.77193006
66	intraciliary transport (GO:0042073)	2.75488759
67	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.75384715
68	estrogen biosynthetic process (GO:0006703)	2.73766414
69	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.69004535
70	head development (GO:0060322)	2.68807117
71	detection of light stimulus involved in sensory perception (GO:0050962)	2.67462576
72	detection of light stimulus involved in visual perception (GO:0050908)	2.67462576
73	cAMP catabolic process (GO:0006198)	2.65721313
74	viral life cycle (GO:0019058)	2.65392873
75	hydrogen ion transmembrane transport (GO:1902600)	2.63019397
76	protein polyglutamylation (GO:0018095)	2.62415293
77	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.62100275
78	water-soluble vitamin biosynthetic process (GO:0042364)	2.61414080
79	proton transport (GO:0015992)	2.58733448
80	translational initiation (GO:0006413)	2.58203725
81	cellular biogenic amine catabolic process (GO:0042402)	2.58094824
82	amine catabolic process (GO:0009310)	2.58094824
83	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.51757356
84	hydrogen transport (GO:0006818)	2.51703674
85	axoneme assembly (GO:0035082)	2.51424205
86	photoreceptor cell maintenance (GO:0045494)	2.50310635
87	epithelial cilium movement (GO:0003351)	2.48734022
88	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.47532404
89	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.47532404
90	maturation of SSU-rRNA (GO:0030490)	2.46935072
91	translation (GO:0006412)	2.46624377
92	prenylation (GO:0097354)	2.44176487
93	protein prenylation (GO:0018342)	2.44176487
94	replication fork processing (GO:0031297)	2.43540198
95	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.42593382
96	DNA demethylation (GO:0080111)	2.42570424
97	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.41243245
98	response to nitrosative stress (GO:0051409)	2.40484956
99	sulfation (GO:0051923)	2.40181577
100	DNA double-strand break processing (GO:0000729)	2.39297152

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.11009073
2	VDR_22108803_ChIP-Seq_LS180_Human	3.06035557
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.83607646
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.59637456
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.48045044
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.34715767
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.27663331
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.25824607
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.21221937
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.20535000
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.14905163
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.11990156
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.04092242
14	FUS_26573619_Chip-Seq_HEK293_Human	1.99961414
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96505859
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.92455157
17	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.89060667
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.86674476
19	EWS_26573619_Chip-Seq_HEK293_Human	1.85703335
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.77787539
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.77772804
22	P300_19829295_ChIP-Seq_ESCs_Human	1.76768931
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.75299210
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.75127439
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72981893
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.68485138
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66716311
28	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.65959000
29	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.62040218
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.61070424
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.59871124
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54487751
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.54277145
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50043708
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50043708
36	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.48652381
37	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47947073
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43678526
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.43514355
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.40380371
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40286211
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40286211
43	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.39247341
44	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39085261
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.39031491
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38929061
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.35080332
48	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.35078147
49	SMAD4_21799915_ChIP-Seq_A2780_Human	1.30578505
50	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30509295
51	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.29920097
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28512784
53	* NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28511609
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28182394
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28182394
56	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.27935097
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27614054
58	AR_25329375_ChIP-Seq_VCAP_Human	1.26829779
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.26739814
60	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.26337372
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.26087699
62	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.26015537
63	TAF15_26573619_Chip-Seq_HEK293_Human	1.25884329
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.24636059
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24520401
66	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23908531
67	CBP_20019798_ChIP-Seq_JUKART_Human	1.23908531
68	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.21694503
69	TCF4_23295773_ChIP-Seq_U87_Human	1.21689445
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18804324
71	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.16963423
72	AR_20517297_ChIP-Seq_VCAP_Human	1.15672508
73	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.15160498
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14492653
75	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13803213
76	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.13525541
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13353219
78	NCOR_22424771_ChIP-Seq_293T_Human	1.09725449
79	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.09515221
80	MYC_19829295_ChIP-Seq_ESCs_Human	1.09311248
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09195869
82	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08548272
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08348651
84	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08001859
85	STAT3_23295773_ChIP-Seq_U87_Human	1.07711672
86	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05695908
87	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05490076
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03895587
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.03371056
90	* HOXB7_26014856_ChIP-Seq_BT474_Human	1.02890768
91	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.02817735
92	TP53_16413492_ChIP-PET_HCT116_Human	1.02580863
93	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.01962788
94	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01558404
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00718001
96	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.00606335
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00566081
98	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00229988
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.99886209
100	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.99781425

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.82929583
2	MP0006292_abnormal_olfactory_placode	3.72961641
3	MP0003787_abnormal_imprinting	3.51008613
4	MP0008789_abnormal_olfactory_epithelium	2.81230569
5	MP0004742_abnormal_vestibular_system	2.55019445
6	MP0002102_abnormal_ear_morphology	2.39498123
7	MP0004885_abnormal_endolymph	2.29712749
8	MP0004142_abnormal_muscle_tone	2.18943066
9	MP0002736_abnormal_nociception_after	2.14916292
10	MP0008875_abnormal_xenobiotic_pharmacok	2.13472063
11	MP0001968_abnormal_touch/_nociception	2.11751457
12	MP0008877_abnormal_DNA_methylation	2.10971202
13	MP0003121_genomic_imprinting	2.10925573
14	MP0002837_dystrophic_cardiac_calcinosis	2.09419268
15	MP0005551_abnormal_eye_electrophysiolog	2.03052367
16	MP0005499_abnormal_olfactory_system	2.02919353
17	MP0005394_taste/olfaction_phenotype	2.02919353
18	MP0006072_abnormal_retinal_apoptosis	1.90169500
19	MP0008872_abnormal_physiological_respon	1.90142645
20	MP0000372_irregular_coat_pigmentation	1.87976847
21	MP0001835_abnormal_antigen_presentation	1.86615023
22	MP0001485_abnormal_pinna_reflex	1.85395789
23	MP0006276_abnormal_autonomic_nervous	1.79706745
24	MP0003646_muscle_fatigue	1.76148980
25	MP0003122_maternal_imprinting	1.56098500
26	MP0002272_abnormal_nervous_system	1.55137666
27	MP0000427_abnormal_hair_cycle	1.55009106
28	MP0003195_calcinosis	1.52332943
29	MP0001501_abnormal_sleep_pattern	1.49002666
30	MP0003011_delayed_dark_adaptation	1.46004368
31	MP0005379_endocrine/exocrine_gland_phen	1.43642503
32	MP0004147_increased_porphyrin_level	1.40823669
33	MP0001919_abnormal_reproductive_system	1.38646154
34	MP0005377_hearing/vestibular/ear_phenot	1.37488238
35	MP0003878_abnormal_ear_physiology	1.37488238
36	MP0001440_abnormal_grooming_behavior	1.35108201
37	MP0002638_abnormal_pupillary_reflex	1.34177342
38	MP0005253_abnormal_eye_physiology	1.33368784
39	MP0000383_abnormal_hair_follicle	1.28968254
40	MP0001986_abnormal_taste_sensitivity	1.28939792
41	MP0004145_abnormal_muscle_electrophysio	1.28937245
42	MP0005389_reproductive_system_phenotype	1.25477027
43	MP0005645_abnormal_hypothalamus_physiol	1.23008326
44	MP0002163_abnormal_gland_morphology	1.22711579
45	MP0000516_abnormal_urinary_system	1.21954089
46	MP0005367_renal/urinary_system_phenotyp	1.21954089
47	MP0002938_white_spotting	1.21793106
48	MP0001529_abnormal_vocalization	1.20994666
49	MP0001486_abnormal_startle_reflex	1.20879755
50	MP0009745_abnormal_behavioral_response	1.17164652
51	MP0002653_abnormal_ependyma_morphology	1.16050729
52	MP0001905_abnormal_dopamine_level	1.15507448
53	MP0005646_abnormal_pituitary_gland	1.13876845
54	MP0005195_abnormal_posterior_eye	1.12226070
55	MP0001293_anophthalmia	1.11837289
56	MP0000049_abnormal_middle_ear	1.09859112
57	MP0002557_abnormal_social/conspecific_i	1.08809604
58	MP0005174_abnormal_tail_pigmentation	1.08660839
59	MP0005671_abnormal_response_to	1.08655726
60	MP0009046_muscle_twitch	1.05870428
61	MP0002572_abnormal_emotion/affect_behav	1.02429293
62	MP0003123_paternal_imprinting	1.01179836
63	MP0001873_stomach_inflammation	1.01046115
64	MP0001764_abnormal_homeostasis	1.00300956
65	MP0000569_abnormal_digit_pigmentation	0.99090153
66	MP0001970_abnormal_pain_threshold	0.98748151
67	MP0000026_abnormal_inner_ear	0.98263811
68	MP0003880_abnormal_central_pattern	0.98016425
69	MP0002095_abnormal_skin_pigmentation	0.97567132
70	MP0000631_abnormal_neuroendocrine_gland	0.97326282
71	MP0002876_abnormal_thyroid_physiology	0.96332374
72	MP0001963_abnormal_hearing_physiology	0.95672782
73	MP0000778_abnormal_nervous_system	0.94768724
74	MP0002735_abnormal_chemical_nociception	0.91909936
75	MP0003186_abnormal_redox_activity	0.88868545
76	MP0005423_abnormal_somatic_nervous	0.88836535
77	MP0005410_abnormal_fertilization	0.88655915
78	MP0000647_abnormal_sebaceous_gland	0.88518973
79	MP0002752_abnormal_somatic_nervous	0.86809076
80	MP0008058_abnormal_DNA_repair	0.86134536
81	MP0009053_abnormal_anal_canal	0.85986812
82	MP0009785_altered_susceptibility_to	0.84754333
83	MP0009764_decreased_sensitivity_to	0.83973044
84	MP0001790_abnormal_immune_system	0.82143606
85	MP0005387_immune_system_phenotype	0.82143606
86	MP0000230_abnormal_systemic_arterial	0.81439769
87	MP0001984_abnormal_olfaction	0.80956246
88	MP0006054_spinal_hemorrhage	0.80797513
89	MP0002160_abnormal_reproductive_system	0.80328673
90	MP0002734_abnormal_mechanical_nocicepti	0.77404892
91	MP0008775_abnormal_heart_ventricle	0.76904423
92	MP0002184_abnormal_innervation	0.76543969
93	MP0001800_abnormal_humoral_immune	0.74184550
94	MP0004924_abnormal_behavior	0.73519261
95	MP0005386_behavior/neurological_phenoty	0.73519261
96	MP0002067_abnormal_sensory_capabilities	0.72904453
97	MP0002064_seizures	0.72812285
98	MP0002210_abnormal_sex_determination	0.72516297
99	MP0003633_abnormal_nervous_system	0.70904936
100	MP0002148_abnormal_hypersensitivity_rea	0.69661931

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.16697263
2	Abnormality of midbrain morphology (HP:0002418)	4.15942319
3	Molar tooth sign on MRI (HP:0002419)	4.15942319
4	Progressive macrocephaly (HP:0004481)	3.71426065
5	Mitochondrial inheritance (HP:0001427)	3.60960774
6	Pancreatic fibrosis (HP:0100732)	3.58234786
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.42272255
8	Acute encephalopathy (HP:0006846)	3.39569120
9	Pancreatic cysts (HP:0001737)	3.37350145
10	Increased hepatocellular lipid droplets (HP:0006565)	3.34308461
11	Type II lissencephaly (HP:0007260)	3.27472268
12	Medial flaring of the eyebrow (HP:0010747)	3.17674984
13	Increased CSF lactate (HP:0002490)	3.11951639
14	True hermaphroditism (HP:0010459)	3.08806413
15	Lipid accumulation in hepatocytes (HP:0006561)	3.03616893
16	Absent/shortened dynein arms (HP:0200106)	2.97005165
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.97005165
18	Congenital stationary night blindness (HP:0007642)	2.86950206
19	Nephronophthisis (HP:0000090)	2.86246899
20	Exertional dyspnea (HP:0002875)	2.76643365
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.74977648
22	3-Methylglutaconic aciduria (HP:0003535)	2.68928587
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.65981883
24	Cerebral edema (HP:0002181)	2.65411350
25	Cerebellar dysplasia (HP:0007033)	2.65290191
26	Renal Fanconi syndrome (HP:0001994)	2.62069600
27	Hepatocellular necrosis (HP:0001404)	2.60482084
28	Reticulocytopenia (HP:0001896)	2.57906167
29	Congenital, generalized hypertrichosis (HP:0004540)	2.57888117
30	Abolished electroretinogram (ERG) (HP:0000550)	2.57215579
31	Colon cancer (HP:0003003)	2.53790274
32	Gait imbalance (HP:0002141)	2.53636851
33	Optic disc pallor (HP:0000543)	2.52215191
34	Congenital primary aphakia (HP:0007707)	2.51830327
35	Abnormality of the renal medulla (HP:0100957)	2.44870105
36	Type 2 muscle fiber atrophy (HP:0003554)	2.38084669
37	Abnormality of the renal cortex (HP:0011035)	2.37624028
38	Chronic hepatic failure (HP:0100626)	2.26271680
39	Nephrogenic diabetes insipidus (HP:0009806)	2.25240351
40	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.24612813
41	Hyperventilation (HP:0002883)	2.23896495
42	Decreased central vision (HP:0007663)	2.20969494
43	Stomatitis (HP:0010280)	2.20308856
44	Hepatic necrosis (HP:0002605)	2.15405326
45	Abnormality of DNA repair (HP:0003254)	2.12861615
46	Keratoconus (HP:0000563)	2.12737935
47	Increased corneal curvature (HP:0100692)	2.12737935
48	Optic nerve hypoplasia (HP:0000609)	2.11756704
49	Neoplasm of the adrenal cortex (HP:0100641)	2.05606158
50	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.03909867
51	Abnormal respiratory epithelium morphology (HP:0012253)	2.03138403
52	Abnormal respiratory motile cilium morphology (HP:0005938)	2.03138403
53	Abnormal drinking behavior (HP:0030082)	2.03011799
54	Polydipsia (HP:0001959)	2.03011799
55	Cystic liver disease (HP:0006706)	2.02412414
56	Abnormal ciliary motility (HP:0012262)	2.01745476
57	Severe muscular hypotonia (HP:0006829)	1.98782570
58	Pendular nystagmus (HP:0012043)	1.96374407
59	Attenuation of retinal blood vessels (HP:0007843)	1.96205242
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.93981561
61	Sclerocornea (HP:0000647)	1.93580792
62	Abnormality of renal resorption (HP:0011038)	1.92995547
63	Leukodystrophy (HP:0002415)	1.92061597
64	Renal cortical cysts (HP:0000803)	1.90948150
65	Febrile seizures (HP:0002373)	1.90498411
66	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.89543146
67	Metaphyseal dysplasia (HP:0100255)	1.89141616
68	Male pseudohermaphroditism (HP:0000037)	1.87253224
69	Increased serum lactate (HP:0002151)	1.86700497
70	Lactic acidosis (HP:0003128)	1.86141650
71	IgG deficiency (HP:0004315)	1.85942645
72	Postaxial foot polydactyly (HP:0001830)	1.85033549
73	Increased intramyocellular lipid droplets (HP:0012240)	1.83508300
74	Vaginal atresia (HP:0000148)	1.83108783
75	Postaxial hand polydactyly (HP:0001162)	1.81909470
76	Genital tract atresia (HP:0001827)	1.81517609
77	Macrocytic anemia (HP:0001972)	1.80747831
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.80629415
79	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.79995340
80	Constricted visual fields (HP:0001133)	1.79739526
81	Stenosis of the external auditory canal (HP:0000402)	1.79295475
82	Abnormality of cells of the erythroid lineage (HP:0012130)	1.79020717
83	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.77131261
84	Hypoplasia of the fovea (HP:0007750)	1.77131261
85	Anencephaly (HP:0002323)	1.76787145
86	Growth hormone deficiency (HP:0000824)	1.75782830
87	Inability to walk (HP:0002540)	1.74618550
88	Poor coordination (HP:0002370)	1.74468340
89	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.73035462
90	Abnormal hemoglobin (HP:0011902)	1.72078523
91	Amblyopia (HP:0000646)	1.70986742
92	Thyroiditis (HP:0100646)	1.70647611
93	Anophthalmia (HP:0000528)	1.70414863
94	Focal seizures (HP:0007359)	1.70332948
95	Tubular atrophy (HP:0000092)	1.69740477
96	Septo-optic dysplasia (HP:0100842)	1.68713894
97	Enlarged kidneys (HP:0000105)	1.68358508
98	Retinal dysplasia (HP:0007973)	1.68322345
99	Hypoplasia of the ulna (HP:0003022)	1.68134506
100	Absent thumb (HP:0009777)	1.68002686

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BRSK2	3.60253716
2	FRK	3.29764944
3	WEE1	2.93819202
4	NUAK1	2.74238214
5	ACVR1B	2.68640251
6	BMPR1B	2.66076654
7	MAP4K2	2.36667410
8	MST4	2.30732713
9	TAOK3	2.28343602
10	TNIK	2.25473927
11	VRK2	2.22283366
12	ZAK	2.18656094
13	ADRBK2	2.14807328
14	GRK1	2.00263765
15	WNK3	1.99113596
16	VRK1	1.91804631
17	WNK4	1.88952239
18	CDK8	1.86886099
19	TXK	1.86060805
20	DYRK2	1.85098813
21	MAP3K12	1.80713637
22	TLK1	1.74273084
23	CASK	1.60656373
24	PINK1	1.53678424
25	STK16	1.47787044
26	TIE1	1.37176120
27	TAF1	1.32420342
28	INSRR	1.25128773
29	BRSK1	1.19999663
30	PIK3CA	1.18578938
31	BMPR2	1.17807276
32	PNCK	1.17477802
33	MKNK2	1.15533081
34	TEC	1.14255161
35	EPHB2	1.12422902
36	HIPK2	1.11171756
37	OXSR1	1.10040282
38	CDK19	1.03722538
39	KIT	1.02271524
40	MAPK13	0.95732852
41	PRKCE	0.91028216
42	MAPKAPK5	0.87131091
43	PAK3	0.82713474
44	STK39	0.80832085
45	PLK3	0.76719418
46	ITK	0.76279274
47	PHKG2	0.75998168
48	PHKG1	0.75998168
49	TYRO3	0.74341093
50	CSNK1G3	0.73777418
51	NTRK2	0.72662564
52	ADRBK1	0.71477903
53	FLT3	0.70985258
54	CSNK1G2	0.70569655
55	CSNK1G1	0.70234711
56	TGFBR1	0.69894704
57	EPHA4	0.67417414
58	MUSK	0.66965912
59	MKNK1	0.65658475
60	MAP2K6	0.64263163
61	PRKCG	0.63981329
62	OBSCN	0.61376493
63	MARK3	0.60515560
64	CAMKK2	0.59390995
65	NLK	0.57668708
66	AKT3	0.57277623
67	GRK5	0.56906049
68	IKBKB	0.55368974
69	CSNK1A1L	0.53866756
70	IKBKE	0.51907466
71	MYLK	0.51054628
72	WNK1	0.50026516
73	EIF2AK2	0.49569972
74	PRKACA	0.49528548
75	STK11	0.49311266
76	PLK2	0.48391083
77	CDK4	0.47897646
78	CAMK2A	0.46518429
79	PRKCZ	0.45774026
80	EIF2AK3	0.45607514
81	PRKG1	0.44484411
82	ERBB3	0.44105742
83	TRIM28	0.43583872
84	BCR	0.41483658
85	RPS6KA5	0.41149007
86	FGFR2	0.40959338
87	PRKCI	0.40880734
88	PRKCA	0.40854526
89	MARK1	0.39453692
90	PBK	0.39441392
91	CDK9	0.38738996
92	DYRK1A	0.38580099
93	AURKB	0.37551705
94	BTK	0.36598418
95	JAK3	0.36533178
96	FES	0.35943026
97	CSNK2A1	0.35579856
98	CAMK1	0.34857269
99	DAPK3	0.34755722
100	CAMK2D	0.34273354

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.69383976
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.34724245
3	Asthma_Homo sapiens_hsa05310	3.18523426
4	Protein export_Homo sapiens_hsa03060	3.12342854
5	Parkinsons disease_Homo sapiens_hsa05012	2.69118615
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.49287651
7	Allograft rejection_Homo sapiens_hsa05330	2.26249337
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.17354314
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.14702939
10	Homologous recombination_Homo sapiens_hsa03440	2.03751867
11	Caffeine metabolism_Homo sapiens_hsa00232	2.02179249
12	Proteasome_Homo sapiens_hsa03050	1.99768741
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96796811
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.92363601
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.90727028
16	RNA polymerase_Homo sapiens_hsa03020	1.85929731
17	Alzheimers disease_Homo sapiens_hsa05010	1.82923694
18	Huntingtons disease_Homo sapiens_hsa05016	1.80095102
19	Basal transcription factors_Homo sapiens_hsa03022	1.71696714
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.70072306
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.65239780
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.63601780
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.62640797
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.58849002
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.57888688
26	Phototransduction_Homo sapiens_hsa04744	1.47035828
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44685854
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.41959342
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.41503956
30	RNA degradation_Homo sapiens_hsa03018	1.33140112
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.33032717
32	Mismatch repair_Homo sapiens_hsa03430	1.32115633
33	One carbon pool by folate_Homo sapiens_hsa00670	1.29267794
34	Butanoate metabolism_Homo sapiens_hsa00650	1.25947263
35	Propanoate metabolism_Homo sapiens_hsa00640	1.24372002
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22341520
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.20777217
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19839697
39	Olfactory transduction_Homo sapiens_hsa04740	1.17715846
40	Primary immunodeficiency_Homo sapiens_hsa05340	1.17078381
41	Rheumatoid arthritis_Homo sapiens_hsa05323	1.11280177
42	Antigen processing and presentation_Homo sapiens_hsa04612	1.10879263
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.10808434
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06571939
45	Regulation of autophagy_Homo sapiens_hsa04140	1.03953013
46	Nicotine addiction_Homo sapiens_hsa05033	0.99310508
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94138849
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.93457109
49	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.92111138
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.81998483
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79038907
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.78674732
53	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78659291
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75914012
55	Morphine addiction_Homo sapiens_hsa05032	0.74042260
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73791836
57	Insulin secretion_Homo sapiens_hsa04911	0.70386712
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.67326771
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66992736
60	Retinol metabolism_Homo sapiens_hsa00830	0.66188038
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65742044
62	Viral myocarditis_Homo sapiens_hsa05416	0.64091595
63	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.64019647
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62764139
65	Peroxisome_Homo sapiens_hsa04146	0.60535099
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.58192817
67	Purine metabolism_Homo sapiens_hsa00230	0.57213877
68	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.53930162
69	Non-homologous end-joining_Homo sapiens_hsa03450	0.52860721
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52143546
71	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.49618754
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48988640
73	Serotonergic synapse_Homo sapiens_hsa04726	0.47829039
74	ABC transporters_Homo sapiens_hsa02010	0.47704488
75	Metabolic pathways_Homo sapiens_hsa01100	0.46920633
76	Fatty acid elongation_Homo sapiens_hsa00062	0.46660516
77	RNA transport_Homo sapiens_hsa03013	0.46287451
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44896228
79	Salivary secretion_Homo sapiens_hsa04970	0.44556037
80	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.43940334
81	Circadian entrainment_Homo sapiens_hsa04713	0.42494907
82	Glutamatergic synapse_Homo sapiens_hsa04724	0.41813988
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41234332
84	Taste transduction_Homo sapiens_hsa04742	0.40765423
85	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40736474
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.40614605
87	Mineral absorption_Homo sapiens_hsa04978	0.39182587
88	Pyrimidine metabolism_Homo sapiens_hsa00240	0.39155019
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.39118339
90	Basal cell carcinoma_Homo sapiens_hsa05217	0.38727775
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.34593914
92	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.33604369
93	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.32574316
94	Glutathione metabolism_Homo sapiens_hsa00480	0.32099945
95	GABAergic synapse_Homo sapiens_hsa04727	0.31248432
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27896621
97	African trypanosomiasis_Homo sapiens_hsa05143	0.25870483
98	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.25082985
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.23681805
100	Amphetamine addiction_Homo sapiens_hsa05031	0.23661704

RPL21P44

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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