RPL21P47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal large subunit biogenesis (GO:0042273)5.70706949
2termination of RNA polymerase III transcription (GO:0006386)5.55403227
3transcription elongation from RNA polymerase III promoter (GO:0006385)5.55403227
4positive regulation of interleukin-17 production (GO:0032740)5.03158454
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.92905915
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.70190578
7ATP synthesis coupled proton transport (GO:0015986)4.70190578
8protein complex biogenesis (GO:0070271)4.69160814
9tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.57289260
10RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.57289260
11protein localization to cilium (GO:0061512)4.53633123
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.49316246
13NADH dehydrogenase complex assembly (GO:0010257)4.49316246
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.49316246
15positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.40137305
16regulation of regulatory T cell differentiation (GO:0045589)4.38341135
17transcription elongation from RNA polymerase I promoter (GO:0006362)4.26917985
18mitochondrial respiratory chain complex assembly (GO:0033108)4.26788994
19regulation of T cell tolerance induction (GO:0002664)4.23209625
20regulation of cellular respiration (GO:0043457)4.10531108
21regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.06076625
22positive regulation of activated T cell proliferation (GO:0042104)4.01293218
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.01100971
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.93908353
25cotranslational protein targeting to membrane (GO:0006613)3.83531777
26termination of RNA polymerase I transcription (GO:0006363)3.81493694
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.76892702
28protein targeting to ER (GO:0045047)3.76817413
29proteasome assembly (GO:0043248)3.71807312
30myeloid dendritic cell activation (GO:0001773)3.70667171
31protein localization to endoplasmic reticulum (GO:0070972)3.69091749
32myeloid dendritic cell differentiation (GO:0043011)3.68062139
33aldehyde catabolic process (GO:0046185)3.67334847
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.66549823
35positive regulation of type 2 immune response (GO:0002830)3.65785685
36establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64554578
37platelet dense granule organization (GO:0060155)3.59392462
38positive regulation of isotype switching (GO:0045830)3.58009404
39DNA deamination (GO:0045006)3.56630651
40respiratory electron transport chain (GO:0022904)3.53638740
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53115630
42regulation of tolerance induction (GO:0002643)3.51315257
43RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.50975501
44electron transport chain (GO:0022900)3.48486743
45positive regulation of DNA recombination (GO:0045911)3.47555010
46purine-containing compound salvage (GO:0043101)3.45968645
47regulation of isotype switching to IgG isotypes (GO:0048302)3.39453689
48viral transcription (GO:0019083)3.39054608
49translational termination (GO:0006415)3.38057604
50transcription initiation from RNA polymerase I promoter (GO:0006361)3.35885454
51mismatch repair (GO:0006298)3.31054879
52viral protein processing (GO:0019082)3.27300972
53regulation of activated T cell proliferation (GO:0046006)3.16718876
54centriole replication (GO:0007099)3.14806708
55rRNA modification (GO:0000154)3.10625142
56respiratory chain complex IV assembly (GO:0008535)3.08742546
57translation (GO:0006412)3.07201680
58regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.06816019
59translational elongation (GO:0006414)3.06722112
60regulation of interleukin-17 production (GO:0032660)3.05675921
61positive regulation of T-helper cell differentiation (GO:0045624)3.04060883
62membrane budding (GO:0006900)3.02412406
63signal peptide processing (GO:0006465)3.01957933
64regulation of T-helper 2 cell differentiation (GO:0045628)3.01873248
65mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.01668598
66DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98598739
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95965698
68positive regulation of T cell proliferation (GO:0042102)2.95027017
69antigen processing and presentation via MHC class Ib (GO:0002475)2.94219413
70regulation of cellular amino acid metabolic process (GO:0006521)2.93637703
71negative regulation of mast cell activation (GO:0033004)2.92371644
72cytochrome complex assembly (GO:0017004)2.91011147
73transcription from RNA polymerase I promoter (GO:0006360)2.89836245
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88454880
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88454880
76regulation of immunoglobulin secretion (GO:0051023)2.87451728
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86356184
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86356184
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86356184
80antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86287730
81anterograde synaptic vesicle transport (GO:0048490)2.86113233
82negative regulation of B cell apoptotic process (GO:0002903)2.86088372
83tryptophan catabolic process (GO:0006569)2.85002791
84indole-containing compound catabolic process (GO:0042436)2.85002791
85indolalkylamine catabolic process (GO:0046218)2.85002791
86regulation of interleukin-2 biosynthetic process (GO:0045076)2.84109990
87T cell costimulation (GO:0031295)2.83752986
88rRNA methylation (GO:0031167)2.83604213
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83493506
90lymphocyte costimulation (GO:0031294)2.80775601
91interferon-gamma-mediated signaling pathway (GO:0060333)2.80152353
92cytokine biosynthetic process (GO:0042089)2.79335553
93positive regulation of B cell mediated immunity (GO:0002714)2.78006392
94positive regulation of immunoglobulin mediated immune response (GO:0002891)2.78006392
95nucleobase biosynthetic process (GO:0046112)2.77721165
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75153613
97signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73681743
98signal transduction involved in DNA damage checkpoint (GO:0072422)2.73681743
99signal transduction involved in cell cycle checkpoint (GO:0072395)2.68516235
100G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.67896398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.81533378
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.67378619
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.26236405
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03214313
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.02599553
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.91937499
7TAF15_26573619_Chip-Seq_HEK293_Human2.83174637
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.80559195
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57586043
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55148705
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50305720
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.48505472
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.36285302
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.32889111
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.30133640
16VDR_23849224_ChIP-Seq_CD4+_Human2.28417359
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.24238433
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24054582
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.20981267
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09988295
21ELK1_19687146_ChIP-ChIP_HELA_Human2.02370894
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98602431
23FOXP3_21729870_ChIP-Seq_TREG_Human1.97752497
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91766089
25ER_23166858_ChIP-Seq_MCF-7_Human1.84820880
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.79789216
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.70935637
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.70247773
29IGF1R_20145208_ChIP-Seq_DFB_Human1.67973171
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62466814
31AUTS2_25519132_ChIP-Seq_293T-REX_Human1.61447118
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59238613
33SOX2_19829295_ChIP-Seq_ESCs_Human1.58399338
34NANOG_19829295_ChIP-Seq_ESCs_Human1.58399338
35GATA3_26560356_Chip-Seq_TH2_Human1.53170119
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50898578
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50831962
38HTT_18923047_ChIP-ChIP_STHdh_Human1.48861935
39EWS_26573619_Chip-Seq_HEK293_Human1.48185401
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.47031373
41TP53_22573176_ChIP-Seq_HFKS_Human1.44201245
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42561091
43P300_19829295_ChIP-Seq_ESCs_Human1.42096440
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39163793
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36841075
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.36841075
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35108577
48EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34559100
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34153337
50EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33470621
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32911393
52ZNF274_21170338_ChIP-Seq_K562_Hela1.32713689
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30120635
54TTF2_22483619_ChIP-Seq_HELA_Human1.29981375
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29705200
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28911927
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.27706538
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.26797705
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26766569
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24080656
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23863072
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23337756
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.22911915
64MYC_18940864_ChIP-ChIP_HL60_Human1.20071298
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18839111
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18411123
67SPI1_23547873_ChIP-Seq_NB4_Human1.17496727
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16795167
69CDX2_22108803_ChIP-Seq_LS180_Human1.16376715
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15782521
71SMRT_27268052_Chip-Seq_Bcells_Human1.12019040
72SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11924168
73P300_18555785_Chip-Seq_ESCs_Mouse1.11520637
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.11170488
75GBX2_23144817_ChIP-Seq_PC3_Human1.10070599
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09849568
77CBP_20019798_ChIP-Seq_JUKART_Human1.09849568
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.09641727
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.09132134
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08567592
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.08165150
82OCT4_18555785_Chip-Seq_ESCs_Mouse1.07973205
83FUS_26573619_Chip-Seq_HEK293_Human1.07740145
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07606486
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07017864
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06583572
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06218937
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04744867
89P53_22387025_ChIP-Seq_ESCs_Mouse1.04315695
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.04179506
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03599417
92PU1_27457419_Chip-Seq_LIVER_Mouse1.02602902
93CTCF_18555785_Chip-Seq_ESCs_Mouse1.01703842
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01185539
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00855706
96NANOG_18555785_Chip-Seq_ESCs_Mouse0.98801461
97ERG_20517297_ChIP-Seq_VCAP_Human0.98388187
98SALL4_22934838_ChIP-ChIP_CD34+_Human0.97574376
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97007065
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96986604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation7.22161403
2MP0003806_abnormal_nucleotide_metabolis3.60316566
3MP0004142_abnormal_muscle_tone3.08162002
4MP0005671_abnormal_response_to2.98764704
5MP0004147_increased_porphyrin_level2.85930986
6MP0001529_abnormal_vocalization2.81293682
7MP0004145_abnormal_muscle_electrophysio2.60121681
8MP0002837_dystrophic_cardiac_calcinosis2.57980152
9MP0003186_abnormal_redox_activity2.28722726
10MP0005387_immune_system_phenotype2.12636842
11MP0001790_abnormal_immune_system2.12636842
12MP0001800_abnormal_humoral_immune2.12581045
13MP0003172_abnormal_lysosome_physiology2.10916624
14MP0001853_heart_inflammation2.06351532
15MP0008875_abnormal_xenobiotic_pharmacok2.04104392
16MP0009785_altered_susceptibility_to1.98612049
17MP0002138_abnormal_hepatobiliary_system1.96437011
18MP0005670_abnormal_white_adipose1.94115210
19MP0002163_abnormal_gland_morphology1.93695715
20MP0008872_abnormal_physiological_respon1.91551533
21MP0002148_abnormal_hypersensitivity_rea1.87531681
22MP0001440_abnormal_grooming_behavior1.85477721
23MP0000465_gastrointestinal_hemorrhage1.80014248
24MP0006036_abnormal_mitochondrial_physio1.79652858
25MP0002166_altered_tumor_susceptibility1.77056970
26MP0001905_abnormal_dopamine_level1.74983053
27MP0001873_stomach_inflammation1.69514292
28MP0003567_abnormal_fetal_cardiomyocyte1.64102918
29MP0003300_gastrointestinal_ulcer1.53538831
30MP0002452_abnormal_antigen_presenting1.48730346
31MP0005000_abnormal_immune_tolerance1.47787118
32MP0005645_abnormal_hypothalamus_physiol1.41446977
33MP0005379_endocrine/exocrine_gland_phen1.38296995
34MP0006082_CNS_inflammation1.37492785
35MP0004215_abnormal_myocardial_fiber1.36924707
36MP0003183_abnormal_peptide_metabolism1.35305818
37MP0003195_calcinosis1.34606991
38MP0003866_abnormal_defecation1.32862610
39MP0003724_increased_susceptibility_to1.31958322
40MP0001984_abnormal_olfaction1.31755449
41MP0002723_abnormal_immune_serum1.30966776
42MP0003763_abnormal_thymus_physiology1.29126091
43MP0010155_abnormal_intestine_physiology1.28772020
44MP0002090_abnormal_vision1.28414214
45MP0004782_abnormal_surfactant_physiolog1.26695090
46MP0005084_abnormal_gallbladder_morpholo1.22625442
47MP0002006_tumorigenesis1.22207962
48MP0006292_abnormal_olfactory_placode1.22026971
49MP0003137_abnormal_impulse_conducting1.19809095
50MP0010386_abnormal_urinary_bladder1.19396091
51MP0006072_abnormal_retinal_apoptosis1.18821215
52MP0005408_hypopigmentation1.13971946
53MP0005367_renal/urinary_system_phenotyp1.12196162
54MP0000516_abnormal_urinary_system1.12196162
55MP0001819_abnormal_immune_cell1.11034445
56MP0005075_abnormal_melanosome_morpholog1.07186051
57MP0001485_abnormal_pinna_reflex1.05760870
58MP0000685_abnormal_immune_system1.05621782
59MP0005636_abnormal_mineral_homeostasis1.05567031
60MP0000013_abnormal_adipose_tissue1.03179520
61MP0005332_abnormal_amino_acid1.02752229
62MP0002420_abnormal_adaptive_immunity1.00310928
63MP0002693_abnormal_pancreas_physiology0.97633886
64MP0005025_abnormal_response_to0.96863624
65MP0006035_abnormal_mitochondrial_morpho0.94309065
66MP0001968_abnormal_touch/_nociception0.94152286
67MP0001845_abnormal_inflammatory_respons0.92699425
68MP0009333_abnormal_splenocyte_physiolog0.91084007
69MP0002102_abnormal_ear_morphology0.90348384
70MP0002751_abnormal_autonomic_nervous0.89513664
71MP0002736_abnormal_nociception_after0.89362563
72MP0000538_abnormal_urinary_bladder0.89278262
73MP0002254_reproductive_system_inflammat0.88858669
74MP0005551_abnormal_eye_electrophysiolog0.88023569
75MP0002234_abnormal_pharynx_morphology0.85536753
76MP0008469_abnormal_protein_level0.82934245
77MP0001486_abnormal_startle_reflex0.82372057
78MP0005389_reproductive_system_phenotype0.80561992
79MP0009697_abnormal_copulation0.80408873
80MP0000716_abnormal_immune_system0.78588539
81MP0005253_abnormal_eye_physiology0.78095566
82MP0003718_maternal_effect0.77341454
83MP0000639_abnormal_adrenal_gland0.77248858
84MP0005377_hearing/vestibular/ear_phenot0.76836818
85MP0003878_abnormal_ear_physiology0.76836818
86MP0002398_abnormal_bone_marrow0.76650490
87MP0009643_abnormal_urine_homeostasis0.72881663
88MP0005535_abnormal_body_temperature0.71672433
89MP0005646_abnormal_pituitary_gland0.71536681
90MP0003638_abnormal_response/metabolism_0.70724698
91MP0001756_abnormal_urination0.67591719
92MP0001970_abnormal_pain_threshold0.66528390
93MP0009745_abnormal_behavioral_response0.64669226
94MP0003283_abnormal_digestive_organ0.63295721
95MP0009764_decreased_sensitivity_to0.62516290
96MP0003011_delayed_dark_adaptation0.61101167
97MP0004085_abnormal_heartbeat0.60821736
98MP0002429_abnormal_blood_cell0.60425950
99MP0002272_abnormal_nervous_system0.60257935
100MP0000371_diluted_coat_color0.59723677

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)6.51051570
2Multiple enchondromatosis (HP:0005701)5.76382824
3Acute necrotizing encephalopathy (HP:0006965)5.67727131
4Hepatic necrosis (HP:0002605)5.61045405
5Abnormal mitochondria in muscle tissue (HP:0008316)5.36346116
6Progressive macrocephaly (HP:0004481)5.19774376
7Mitochondrial inheritance (HP:0001427)4.76040318
8Acute encephalopathy (HP:0006846)4.52744918
9Increased CSF lactate (HP:0002490)4.17944474
10Cleft eyelid (HP:0000625)3.93688504
11Methylmalonic acidemia (HP:0002912)3.55189411
12Leukodystrophy (HP:0002415)3.50736931
133-Methylglutaconic aciduria (HP:0003535)3.46642487
14Hypoproteinemia (HP:0003075)3.33527199
15Aplastic anemia (HP:0001915)3.26112259
16Cerebral edema (HP:0002181)3.18687344
17Cerebral palsy (HP:0100021)3.18525585
18Respiratory failure (HP:0002878)3.08668206
19IgG deficiency (HP:0004315)3.07794810
20Elevated erythrocyte sedimentation rate (HP:0003565)3.03976453
21Decreased activity of mitochondrial respiratory chain (HP:0008972)2.94405259
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.94405259
23Split foot (HP:0001839)2.93538696
24Congenital, generalized hypertrichosis (HP:0004540)2.81377304
25Chronic diarrhea (HP:0002028)2.77449831
26Increased IgM level (HP:0003496)2.75848784
27Obstructive lung disease (HP:0006536)2.72131779
28Chronic obstructive pulmonary disease (HP:0006510)2.72131779
29Trismus (HP:0000211)2.71401560
30Methylmalonic aciduria (HP:0012120)2.69563072
31Type II lissencephaly (HP:0007260)2.62898971
32Hemoptysis (HP:0002105)2.61587497
33Median cleft lip (HP:0000161)2.59951587
34Optic disc pallor (HP:0000543)2.56314036
35Spastic paraparesis (HP:0002313)2.55402180
36Glossoptosis (HP:0000162)2.55091916
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.44994325
38Aplasia/hypoplasia of the uterus (HP:0008684)2.44387570
39Hypoplasia of the pons (HP:0012110)2.42921560
40CNS demyelination (HP:0007305)2.37138053
41Abolished electroretinogram (ERG) (HP:0000550)2.36571032
42B lymphocytopenia (HP:0010976)2.36239962
43Abnormality of the prostate (HP:0008775)2.33588227
44Macrocytic anemia (HP:0001972)2.33143959
45Increased serum lactate (HP:0002151)2.31274407
46Flat occiput (HP:0005469)2.31011249
47Abnormality of the vitamin B12 metabolism (HP:0004341)2.27763344
48Vasculitis (HP:0002633)2.27471670
49Hypoplasia of the uterus (HP:0000013)2.26211474
50Abnormality of the pleura (HP:0002103)2.24257494
51Abnormality of the pons (HP:0007361)2.19708771
52Abnormality of vitamin B metabolism (HP:0004340)2.19588032
53Global brain atrophy (HP:0002283)2.19225534
54Stomatitis (HP:0010280)2.18815973
55Hypoglycemic seizures (HP:0002173)2.17613430
56Exercise intolerance (HP:0003546)2.16365670
57Thyroiditis (HP:0100646)2.12610414
58Cerebellar dysplasia (HP:0007033)2.11772137
59Abnormality of methionine metabolism (HP:0010901)2.10384187
60Tetany (HP:0001281)2.07485080
61Lactic acidosis (HP:0003128)2.06017007
62Severe combined immunodeficiency (HP:0004430)2.04435047
63Hypoalbuminemia (HP:0003073)2.03306640
64Abnormal albumin level (HP:0012116)2.03306640
65Porencephaly (HP:0002132)2.02576173
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00329978
67Hypomagnesemia (HP:0002917)1.98218615
68Increased hepatocellular lipid droplets (HP:0006565)1.94008938
69Stenosis of the external auditory canal (HP:0000402)1.93510441
70Emotional lability (HP:0000712)1.93336178
71Abnormality of B cell number (HP:0010975)1.93229353
72Facial cleft (HP:0002006)1.92099991
73Homocystinuria (HP:0002156)1.89637454
74Abnormality of homocysteine metabolism (HP:0010919)1.89637454
75Female pseudohermaphroditism (HP:0010458)1.89200342
76X-linked dominant inheritance (HP:0001423)1.89192020
77Sensory axonal neuropathy (HP:0003390)1.88125506
78Acute hepatic failure (HP:0006554)1.87654259
79Abnormal cartilage morphology (HP:0002763)1.86720478
80Hypothermia (HP:0002045)1.86625713
81Abnormality of lateral ventricle (HP:0030047)1.85912817
82Lipid accumulation in hepatocytes (HP:0006561)1.85819445
83Pancytopenia (HP:0001876)1.85544118
84Recurrent cutaneous fungal infections (HP:0011370)1.85233063
85Chronic mucocutaneous candidiasis (HP:0002728)1.85233063
86Choanal stenosis (HP:0000452)1.84238173
87Pulmonary infiltrates (HP:0002113)1.81604358
88Pulmonary fibrosis (HP:0002206)1.79940172
89Genetic anticipation (HP:0003743)1.79748318
90Gliosis (HP:0002171)1.78411539
91Lethargy (HP:0001254)1.78186072
92Molar tooth sign on MRI (HP:0002419)1.77295898
93Abnormality of midbrain morphology (HP:0002418)1.77295898
94Increased intramyocellular lipid droplets (HP:0012240)1.76682116
95Aplasia/Hypoplasia of the thymus (HP:0010515)1.75834343
96Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75351757
97Dicarboxylic aciduria (HP:0003215)1.75351757
98Abnormal hemoglobin (HP:0011902)1.75165758
99Polyneuropathy (HP:0001271)1.74489093
100Blindness (HP:0000618)1.74129942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K135.09382439
2SCYL24.99391315
3TXK4.30135988
4MST43.97796809
5MAP4K13.11421019
6MAP3K122.94040856
7FRK2.75829065
8EIF2AK12.65101352
9MAP3K142.48220970
10BMPR22.33734754
11NEK12.09396307
12EIF2AK32.03234866
13FES1.88015361
14TSSK61.85718277
15TRIM281.78498742
16PRKG21.71234166
17MYLK1.67753463
18TLK11.61084351
19NEK91.57281057
20NME21.53649062
21IKBKB1.51991611
22ADRBK21.47121268
23GRK11.37953637
24FLT31.22156690
25NUAK11.19044220
26PIK3CA1.17253890
27ILK1.14272975
28TEC1.09557676
29INSRR0.99447828
30RPS6KA40.97983541
31KIT0.97422498
32WNK30.97153154
33RIPK40.95233732
34CSNK1G10.93809919
35TYK20.93163852
36ITK0.93009516
37CSNK1A1L0.91760949
38CDK30.91683124
39OXSR10.90464751
40CSF1R0.89892882
41CSNK1G30.89414049
42LYN0.87939898
43ZAK0.87615073
44PASK0.86416366
45PIK3CG0.84371966
46PAK40.83072054
47ZAP700.82679665
48IKBKE0.81355973
49MAP2K60.81343766
50CSNK1G20.74762674
51SYK0.74437883
52CSK0.72934841
53PRKCE0.72690108
54PRKCQ0.70852533
55OBSCN0.69924572
56PNCK0.66556890
57CDK190.66253650
58MAP4K20.66196941
59MAP3K40.64902254
60RPS6KA50.63785034
61DAPK10.63115037
62DYRK20.62363183
63FGFR10.62136535
64JAK30.59567983
65MKNK20.58090965
66CSNK2A20.55264115
67PHKG20.53238289
68PHKG10.53238289
69AKT30.52606800
70CAMK2D0.52046253
71EGFR0.52016687
72LCK0.50160806
73CHUK0.46156622
74TIE10.44710995
75FGFR20.42065454
76BTK0.40825114
77CSNK2A10.40496916
78PLK10.37613373
79MINK10.37545427
80KDR0.36465252
81HCK0.35873713
82ADRBK10.35769814
83DMPK0.34183823
84JAK10.34103735
85MUSK0.33710398
86ERBB30.33598688
87IGF1R0.33416837
88MAP3K70.33257334
89ATR0.32364637
90MKNK10.31529651
91MAPKAPK30.31100057
92NME10.30652073
93EIF2AK20.30470419
94PLK30.29731318
95TBK10.28736668
96SGK10.27928150
97CAMK2A0.27754976
98TAF10.26677272
99PRKG10.26284111
100ATM0.26224392

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.90301549
2Allograft rejection_Homo sapiens_hsa053304.67081506
3Autoimmune thyroid disease_Homo sapiens_hsa053204.46372589
4Graft-versus-host disease_Homo sapiens_hsa053324.30445728
5Type I diabetes mellitus_Homo sapiens_hsa049404.11621871
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.85912211
7Protein export_Homo sapiens_hsa030603.54530840
8Oxidative phosphorylation_Homo sapiens_hsa001902.88127081
9Proteasome_Homo sapiens_hsa030502.82220911
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60057672
11RNA polymerase_Homo sapiens_hsa030202.48988449
12Viral myocarditis_Homo sapiens_hsa054162.29166924
13Ribosome_Homo sapiens_hsa030102.29048920
14Parkinsons disease_Homo sapiens_hsa050122.23450024
15Rheumatoid arthritis_Homo sapiens_hsa053232.12334272
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.11345711
17Antigen processing and presentation_Homo sapiens_hsa046121.99028883
18Staphylococcus aureus infection_Homo sapiens_hsa051501.84211129
19Regulation of autophagy_Homo sapiens_hsa041401.46025861
20Alzheimers disease_Homo sapiens_hsa050101.45316979
21Leishmaniasis_Homo sapiens_hsa051401.39140992
22Huntingtons disease_Homo sapiens_hsa050161.37653483
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30212542
24Mismatch repair_Homo sapiens_hsa034301.27818522
25RNA degradation_Homo sapiens_hsa030181.16380004
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.15654818
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15548908
28Homologous recombination_Homo sapiens_hsa034401.13081378
29Systemic lupus erythematosus_Homo sapiens_hsa053220.96911702
30Cardiac muscle contraction_Homo sapiens_hsa042600.90861463
31Nucleotide excision repair_Homo sapiens_hsa034200.89786027
32Fatty acid elongation_Homo sapiens_hsa000620.82495488
33RNA transport_Homo sapiens_hsa030130.80405511
34Hematopoietic cell lineage_Homo sapiens_hsa046400.78348981
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76548027
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76021661
37Collecting duct acid secretion_Homo sapiens_hsa049660.75352608
38Pyrimidine metabolism_Homo sapiens_hsa002400.74231211
39Toxoplasmosis_Homo sapiens_hsa051450.73644481
40DNA replication_Homo sapiens_hsa030300.69605195
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67110239
42Epstein-Barr virus infection_Homo sapiens_hsa051690.66293720
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59916717
44Phagosome_Homo sapiens_hsa041450.57660317
45Basal transcription factors_Homo sapiens_hsa030220.54097481
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51637547
47Chemical carcinogenesis_Homo sapiens_hsa052040.51280188
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.50514851
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50423971
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50164602
51Phototransduction_Homo sapiens_hsa047440.50006535
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49373383
53Influenza A_Homo sapiens_hsa051640.47653474
54African trypanosomiasis_Homo sapiens_hsa051430.46735986
55Tryptophan metabolism_Homo sapiens_hsa003800.45989717
56Herpes simplex infection_Homo sapiens_hsa051680.45813033
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.44956884
58Folate biosynthesis_Homo sapiens_hsa007900.44951692
59Purine metabolism_Homo sapiens_hsa002300.44005746
60Tuberculosis_Homo sapiens_hsa051520.42867915
61Fanconi anemia pathway_Homo sapiens_hsa034600.42051611
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41557726
63Primary immunodeficiency_Homo sapiens_hsa053400.41375833
64Base excision repair_Homo sapiens_hsa034100.39715281
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38573721
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34273004
67Measles_Homo sapiens_hsa051620.33036167
68Olfactory transduction_Homo sapiens_hsa047400.32340314
69Spliceosome_Homo sapiens_hsa030400.31545630
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31065888
71Caffeine metabolism_Homo sapiens_hsa002320.30624038
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27428670
73Shigellosis_Homo sapiens_hsa051310.27329604
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26193721
75Peroxisome_Homo sapiens_hsa041460.24947497
76N-Glycan biosynthesis_Homo sapiens_hsa005100.24347207
77Retinol metabolism_Homo sapiens_hsa008300.23025807
78Propanoate metabolism_Homo sapiens_hsa006400.22308173
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.22298279
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22238624
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19038483
82Pertussis_Homo sapiens_hsa051330.18944021
83Salivary secretion_Homo sapiens_hsa049700.18446145
84Butanoate metabolism_Homo sapiens_hsa006500.17350990
85T cell receptor signaling pathway_Homo sapiens_hsa046600.16381404
86Glutathione metabolism_Homo sapiens_hsa004800.16299824
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15921123
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.15291096
89Linoleic acid metabolism_Homo sapiens_hsa005910.15042756
90Metabolic pathways_Homo sapiens_hsa011000.14684161
91HTLV-I infection_Homo sapiens_hsa051660.12518828
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.12030473
93Nicotine addiction_Homo sapiens_hsa050330.11714405
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.11064892
95mRNA surveillance pathway_Homo sapiens_hsa030150.09735663
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08921316
97Legionellosis_Homo sapiens_hsa051340.08574709
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.08369043
99Circadian entrainment_Homo sapiens_hsa047130.07811480
100Non-homologous end-joining_Homo sapiens_hsa034500.06952751

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