RPL21P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)6.62351099
2ATP synthesis coupled proton transport (GO:0015986)6.62351099
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.28631918
4viral transcription (GO:0019083)5.62651145
5translational termination (GO:0006415)5.41140546
6ribosomal small subunit assembly (GO:0000028)5.40959853
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.94109605
8ribosomal large subunit biogenesis (GO:0042273)4.92841926
9cotranslational protein targeting to membrane (GO:0006613)4.88199334
10protein targeting to ER (GO:0045047)4.83704572
11establishment of protein localization to endoplasmic reticulum (GO:0072599)4.62518868
12protein localization to endoplasmic reticulum (GO:0070972)4.61699402
13translational elongation (GO:0006414)4.59819177
14ribosomal small subunit biogenesis (GO:0042274)4.52277657
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.50886942
16respiratory electron transport chain (GO:0022904)4.40427150
17electron transport chain (GO:0022900)4.39038210
18maturation of SSU-rRNA (GO:0030490)4.08728491
19chaperone-mediated protein transport (GO:0072321)4.07248519
20behavioral response to nicotine (GO:0035095)4.06458117
21viral life cycle (GO:0019058)4.04538320
22cellular protein complex disassembly (GO:0043624)3.98307007
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.86275715
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.85961305
25negative regulation of heart rate (GO:0010459)3.85008519
26protein neddylation (GO:0045116)3.82688740
27ATP biosynthetic process (GO:0006754)3.81637406
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.81351822
29NADH dehydrogenase complex assembly (GO:0010257)3.81351822
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.81351822
31translational initiation (GO:0006413)3.73855590
32protein complex biogenesis (GO:0070271)3.65639048
33purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.65068401
34purine nucleoside triphosphate biosynthetic process (GO:0009145)3.63925425
35translation (GO:0006412)3.58290604
36DNA deamination (GO:0045006)3.52210202
37hydrogen ion transmembrane transport (GO:1902600)3.49106473
38positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.39211089
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39208082
40mitochondrial respiratory chain complex assembly (GO:0033108)3.36092774
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.32434071
42protein targeting to membrane (GO:0006612)3.32057063
43proton transport (GO:0015992)3.31155485
44hydrogen transport (GO:0006818)3.26038056
45protein complex disassembly (GO:0043241)3.24259597
46L-fucose catabolic process (GO:0042355)3.16350898
47fucose catabolic process (GO:0019317)3.16350898
48L-fucose metabolic process (GO:0042354)3.16350898
49cellular component biogenesis (GO:0044085)3.14074308
50GTP biosynthetic process (GO:0006183)3.12599885
51macromolecular complex disassembly (GO:0032984)3.11480631
52negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.09195834
53regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.01520204
54ribonucleoside triphosphate biosynthetic process (GO:0009201)2.99923634
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96750385
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96750385
57ribonucleoprotein complex biogenesis (GO:0022613)2.95902066
58positive regulation of interleukin-17 production (GO:0032740)2.95162689
59nuclear-transcribed mRNA catabolic process (GO:0000956)2.93935247
60regulation of immunoglobulin secretion (GO:0051023)2.89746838
61platelet dense granule organization (GO:0060155)2.85149586
62replication fork processing (GO:0031297)2.83911586
63peptidyl-histidine modification (GO:0018202)2.83203039
64mRNA catabolic process (GO:0006402)2.77923438
65regulation of mitotic spindle checkpoint (GO:1903504)2.75444160
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.75444160
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.72535291
68mast cell activation (GO:0045576)2.71831971
69regulation of isotype switching to IgG isotypes (GO:0048302)2.71519072
70rRNA metabolic process (GO:0016072)2.70673391
71protein-cofactor linkage (GO:0018065)2.69168148
72rRNA processing (GO:0006364)2.67757237
73positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.66433994
74proteasome assembly (GO:0043248)2.66401247
75respiratory chain complex IV assembly (GO:0008535)2.65101726
76intracellular protein transmembrane import (GO:0044743)2.63152696
77positive regulation of protein homodimerization activity (GO:0090073)2.62962202
78response to pheromone (GO:0019236)2.61808145
79positive regulation of mast cell activation involved in immune response (GO:0033008)2.61366783
80positive regulation of mast cell degranulation (GO:0043306)2.61366783
81phosphorylated carbohydrate dephosphorylation (GO:0046838)2.60832222
82inositol phosphate dephosphorylation (GO:0046855)2.60832222
83S-adenosylmethionine metabolic process (GO:0046500)2.58723179
84RNA catabolic process (GO:0006401)2.58480823
85regulation of hypersensitivity (GO:0002883)2.58106099
86preassembly of GPI anchor in ER membrane (GO:0016254)2.55563131
87GPI anchor metabolic process (GO:0006505)2.54287041
88tyrosine phosphorylation of STAT protein (GO:0007260)2.53452410
89negative regulation of T cell differentiation in thymus (GO:0033085)2.52700030
90kynurenine metabolic process (GO:0070189)2.52103164
91negative regulation of mast cell activation (GO:0033004)2.51840487
92nucleoside triphosphate biosynthetic process (GO:0009142)2.50474771
93purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.49849663
94purine nucleoside monophosphate biosynthetic process (GO:0009127)2.49849663
95rRNA catabolic process (GO:0016075)2.49430279
96tRNA processing (GO:0008033)2.48954560
97negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.48071187
98positive regulation of mast cell activation (GO:0033005)2.46511566
99GPI anchor biosynthetic process (GO:0006506)2.44421485
100rRNA modification (GO:0000154)2.44299651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.69945846
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.90358854
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.30021802
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.22101290
5VDR_22108803_ChIP-Seq_LS180_Human2.91397675
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.77983681
7ZNF274_21170338_ChIP-Seq_K562_Hela2.49500512
8EZH2_22144423_ChIP-Seq_EOC_Human2.42099186
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.35785323
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.32408662
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28988596
12VDR_23849224_ChIP-Seq_CD4+_Human2.22404850
13ELK1_19687146_ChIP-ChIP_HELA_Human2.17383027
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16380198
15TAF15_26573619_Chip-Seq_HEK293_Human2.08014336
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98747990
17ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95665857
18TP53_22573176_ChIP-Seq_HFKS_Human1.92096405
19FOXP3_21729870_ChIP-Seq_TREG_Human1.85804280
20EWS_26573619_Chip-Seq_HEK293_Human1.81742727
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.79936911
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75037406
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66498095
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66249663
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65388345
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61241865
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59886730
28IGF1R_20145208_ChIP-Seq_DFB_Human1.56510584
29FUS_26573619_Chip-Seq_HEK293_Human1.54581843
30ER_23166858_ChIP-Seq_MCF-7_Human1.54155861
31MYC_18940864_ChIP-ChIP_HL60_Human1.50465567
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.47687051
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.47604528
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.46342624
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46334472
36FOXA1_25329375_ChIP-Seq_VCAP_Human1.46334472
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.43130778
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39912830
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39860914
40P300_19829295_ChIP-Seq_ESCs_Human1.39513133
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38852076
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38537282
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37840643
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37778624
45GATA3_26560356_Chip-Seq_TH2_Human1.37751487
46NANOG_19829295_ChIP-Seq_ESCs_Human1.34056124
47SOX2_19829295_ChIP-Seq_ESCs_Human1.34056124
48CBP_20019798_ChIP-Seq_JUKART_Human1.33160050
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33160050
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.32069601
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31777379
52TTF2_22483619_ChIP-Seq_HELA_Human1.30544080
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30347263
54GBX2_23144817_ChIP-Seq_PC3_Human1.29537490
55AR_20517297_ChIP-Seq_VCAP_Human1.26911806
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26744112
57IRF1_19129219_ChIP-ChIP_H3396_Human1.25793489
58CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24642134
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23430608
60FOXH1_21741376_ChIP-Seq_EPCs_Human1.22485315
61TAF2_19829295_ChIP-Seq_ESCs_Human1.22158632
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.20644281
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18294388
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17443759
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.14870166
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13506479
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13361620
68NCOR_22424771_ChIP-Seq_293T_Human1.12664464
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12233803
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09405474
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.08528353
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07292569
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05075391
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04584758
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04410681
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04089864
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03390060
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02851509
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02814042
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01524569
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00696422
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99643670
83KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99157658
84MYC_19829295_ChIP-Seq_ESCs_Human0.98992539
85TCF4_22108803_ChIP-Seq_LS180_Human0.98303771
86CBX2_27304074_Chip-Seq_ESCs_Mouse0.98019021
87NANOG_20526341_ChIP-Seq_ESCs_Human0.97982036
88ERG_20517297_ChIP-Seq_VCAP_Human0.95797421
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95429942
90CIITA_25753668_ChIP-Seq_RAJI_Human0.94377958
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93631416
92ERA_21632823_ChIP-Seq_H3396_Human0.93280745
93BCAT_22108803_ChIP-Seq_LS180_Human0.92835737
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92655964
95HOXB7_26014856_ChIP-Seq_BT474_Human0.92422179
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90005933
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.89915576
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89671703
99MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89502846
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89146541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.37016662
2MP0001835_abnormal_antigen_presentation4.08244121
3MP0005671_abnormal_response_to2.84630182
4MP0006292_abnormal_olfactory_placode2.63339353
5MP0008877_abnormal_DNA_methylation2.31141711
6MP0005646_abnormal_pituitary_gland2.16998962
7MP0004142_abnormal_muscle_tone2.16511744
8MP0006072_abnormal_retinal_apoptosis2.08507261
9MP0003806_abnormal_nucleotide_metabolis2.05823718
10MP0001968_abnormal_touch/_nociception2.05210492
11MP0008872_abnormal_physiological_respon1.98022528
12MP0002876_abnormal_thyroid_physiology1.95848139
13MP0008875_abnormal_xenobiotic_pharmacok1.95635293
14MP0003195_calcinosis1.89900896
15MP0002736_abnormal_nociception_after1.88704520
16MP0005075_abnormal_melanosome_morpholog1.85379941
17MP0004145_abnormal_muscle_electrophysio1.83225859
18MP0001986_abnormal_taste_sensitivity1.73743829
19MP0005645_abnormal_hypothalamus_physiol1.69754784
20MP0003880_abnormal_central_pattern1.69498495
21MP0005551_abnormal_eye_electrophysiolog1.66610956
22MP0001800_abnormal_humoral_immune1.65638455
23MP0003646_muscle_fatigue1.64384251
24MP0000685_abnormal_immune_system1.63224461
25MP0004147_increased_porphyrin_level1.62808972
26MP0000372_irregular_coat_pigmentation1.61893241
27MP0003787_abnormal_imprinting1.60162872
28MP0003724_increased_susceptibility_to1.58647013
29MP0002102_abnormal_ear_morphology1.57401536
30MP0005253_abnormal_eye_physiology1.48077292
31MP0001348_abnormal_lacrimal_gland1.47308315
32MP0002272_abnormal_nervous_system1.41677151
33MP0006036_abnormal_mitochondrial_physio1.36380993
34MP0005000_abnormal_immune_tolerance1.34680604
35MP0002148_abnormal_hypersensitivity_rea1.34421187
36MP0001873_stomach_inflammation1.32902179
37MP0002163_abnormal_gland_morphology1.32401147
38MP0002837_dystrophic_cardiac_calcinosis1.31209188
39MP0008995_early_reproductive_senescence1.29287751
40MP0006276_abnormal_autonomic_nervous1.29279945
41MP0005377_hearing/vestibular/ear_phenot1.24976054
42MP0003878_abnormal_ear_physiology1.24976054
43MP0003283_abnormal_digestive_organ1.24394360
44MP0004742_abnormal_vestibular_system1.22271927
45MP0001485_abnormal_pinna_reflex1.21751247
46MP0001919_abnormal_reproductive_system1.21443081
47MP0001905_abnormal_dopamine_level1.20860571
48MP0002735_abnormal_chemical_nociception1.20771274
49MP0002723_abnormal_immune_serum1.20596656
50MP0009785_altered_susceptibility_to1.19375475
51MP0005389_reproductive_system_phenotype1.19304193
52MP0006082_CNS_inflammation1.18487487
53MP0003011_delayed_dark_adaptation1.17702028
54MP0005084_abnormal_gallbladder_morpholo1.16654671
55MP0009745_abnormal_behavioral_response1.15040490
56MP0001790_abnormal_immune_system1.13061330
57MP0005387_immune_system_phenotype1.13061330
58MP0003186_abnormal_redox_activity1.13024631
59MP0005367_renal/urinary_system_phenotyp1.11890856
60MP0000516_abnormal_urinary_system1.11890856
61MP0002452_abnormal_antigen_presenting1.11787959
62MP0009764_decreased_sensitivity_to1.10908418
63MP0003786_premature_aging1.09093636
64MP0004885_abnormal_endolymph1.08886755
65MP0005332_abnormal_amino_acid1.07314289
66MP0001970_abnormal_pain_threshold1.05633257
67MP0001529_abnormal_vocalization1.05488767
68MP0005085_abnormal_gallbladder_physiolo1.02790125
69MP0002938_white_spotting1.01530326
70MP0004043_abnormal_pH_regulation1.00258053
71MP0001486_abnormal_startle_reflex0.99949607
72MP0009046_muscle_twitch0.99541295
73MP0002420_abnormal_adaptive_immunity0.99207260
74MP0001819_abnormal_immune_cell0.98282601
75MP0002166_altered_tumor_susceptibility0.97692920
76MP0005423_abnormal_somatic_nervous0.95480662
77MP0002138_abnormal_hepatobiliary_system0.94157608
78MP0005408_hypopigmentation0.94157489
79MP0005636_abnormal_mineral_homeostasis0.93560909
80MP0008775_abnormal_heart_ventricle0.92634130
81MP0008789_abnormal_olfactory_epithelium0.91463745
82MP0001853_heart_inflammation0.90671317
83MP0002006_tumorigenesis0.90194022
84MP0001440_abnormal_grooming_behavior0.85142836
85MP0002638_abnormal_pupillary_reflex0.83436774
86MP0000631_abnormal_neuroendocrine_gland0.82385411
87MP0002160_abnormal_reproductive_system0.82041554
88MP0005379_endocrine/exocrine_gland_phen0.81937006
89MP0005025_abnormal_response_to0.81248653
90MP0002254_reproductive_system_inflammat0.81171945
91MP0001845_abnormal_inflammatory_respons0.79327111
92MP0000230_abnormal_systemic_arterial0.78481254
93MP0000569_abnormal_digit_pigmentation0.78226572
94MP0002095_abnormal_skin_pigmentation0.78108866
95MP0001501_abnormal_sleep_pattern0.77952476
96MP0001293_anophthalmia0.77666474
97MP0001765_abnormal_ion_homeostasis0.77048471
98MP0002572_abnormal_emotion/affect_behav0.76509464
99MP0003183_abnormal_peptide_metabolism0.75269268
100MP0003252_abnormal_bile_duct0.74510912

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.67035412
2Mitochondrial inheritance (HP:0001427)4.44599153
33-Methylglutaconic aciduria (HP:0003535)4.36403225
4Abnormal mitochondria in muscle tissue (HP:0008316)4.09664676
5Increased CSF lactate (HP:0002490)4.06953817
6Hepatocellular necrosis (HP:0001404)3.99615663
7Progressive macrocephaly (HP:0004481)3.96826059
8Acute encephalopathy (HP:0006846)3.92096677
9Abnormality of midbrain morphology (HP:0002418)3.69975733
10Molar tooth sign on MRI (HP:0002419)3.69975733
11Increased hepatocellular lipid droplets (HP:0006565)3.65286835
12Lipid accumulation in hepatocytes (HP:0006561)3.61543548
13Hepatic necrosis (HP:0002605)3.53471434
14Congenital stationary night blindness (HP:0007642)3.50581833
15Reticulocytopenia (HP:0001896)3.43910897
16Abnormality of cells of the erythroid lineage (HP:0012130)3.34241337
17Stomatitis (HP:0010280)3.22496573
18IgG deficiency (HP:0004315)3.21679025
19Exertional dyspnea (HP:0002875)3.18352632
20Congenital, generalized hypertrichosis (HP:0004540)3.12908613
21Renal Fanconi syndrome (HP:0001994)2.96783276
22Macrocytic anemia (HP:0001972)2.96374557
23Cerebral edema (HP:0002181)2.85189889
24Testicular atrophy (HP:0000029)2.83349693
25Absent/shortened dynein arms (HP:0200106)2.82926122
26Dynein arm defect of respiratory motile cilia (HP:0012255)2.82926122
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.81518436
28Nephronophthisis (HP:0000090)2.81271261
29Abolished electroretinogram (ERG) (HP:0000550)2.77160703
30Increased intramyocellular lipid droplets (HP:0012240)2.76292143
31Elevated erythrocyte sedimentation rate (HP:0003565)2.72509737
32Increased serum lactate (HP:0002151)2.72254479
33Pancreatic cysts (HP:0001737)2.72228086
34Optic disc pallor (HP:0000543)2.67287069
35Abnormal number of erythroid precursors (HP:0012131)2.59002401
36Lactic acidosis (HP:0003128)2.56219824
37Abnormal rod and cone electroretinograms (HP:0008323)2.43892566
38Increased muscle lipid content (HP:0009058)2.42529362
39Pancreatic fibrosis (HP:0100732)2.39403292
40Methylmalonic acidemia (HP:0002912)2.36500249
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34844047
42Respiratory failure (HP:0002878)2.34112366
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33237103
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33237103
45Renal cortical cysts (HP:0000803)2.30744573
46Hypomagnesemia (HP:0002917)2.29040265
47Leukodystrophy (HP:0002415)2.27421434
48Abnormality of the renal medulla (HP:0100957)2.26892924
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.26808490
50Abnormality of the renal cortex (HP:0011035)2.23027210
51Pallor (HP:0000980)2.22715089
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22361594
53Abnormality of the prostate (HP:0008775)2.21755976
54Alveolar cell carcinoma (HP:0006519)2.16315648
55Increased IgM level (HP:0003496)2.15178568
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.14863555
57Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.14722363
58Abnormality of magnesium homeostasis (HP:0004921)2.08423527
59Severe combined immunodeficiency (HP:0004430)2.07532857
60Abnormality of the phalanges of the 5th finger (HP:0004213)2.04782750
61Medial flaring of the eyebrow (HP:0010747)2.03860641
62Glycosuria (HP:0003076)2.03062375
63Abnormality of urine glucose concentration (HP:0011016)2.03062375
64Lethargy (HP:0001254)2.01226399
65Parakeratosis (HP:0001036)2.01149885
66B lymphocytopenia (HP:0010976)2.00953869
67Chronic hepatic failure (HP:0100626)1.95322671
68Abnormal biliary tract physiology (HP:0012439)1.93310159
69Bile duct proliferation (HP:0001408)1.93310159
70True hermaphroditism (HP:0010459)1.91656115
71Abnormality of renal resorption (HP:0011038)1.90941821
72Abnormal respiratory motile cilium morphology (HP:0005938)1.90407854
73Abnormal respiratory epithelium morphology (HP:0012253)1.90407854
74Type II lissencephaly (HP:0007260)1.90025692
75Methylmalonic aciduria (HP:0012120)1.87520867
76Respiratory difficulties (HP:0002880)1.86629022
77Abnormality of B cell number (HP:0010975)1.85324854
78Hypoplasia of the fovea (HP:0007750)1.85304950
79Aplasia/Hypoplasia of the fovea (HP:0008060)1.85304950
80Thyroid-stimulating hormone excess (HP:0002925)1.84782922
81Absent thumb (HP:0009777)1.83913043
82Neoplasm of the tracheobronchial system (HP:0100552)1.80276993
83Stenosis of the external auditory canal (HP:0000402)1.79563495
84Exercise intolerance (HP:0003546)1.78945391
85Hypoproteinemia (HP:0003075)1.78192454
86Abnormal ciliary motility (HP:0012262)1.77754306
87Polydipsia (HP:0001959)1.77745206
88Abnormal drinking behavior (HP:0030082)1.77745206
89Thyroiditis (HP:0100646)1.76038243
90Tubular atrophy (HP:0000092)1.75545706
91Symphalangism affecting the phalanges of the hand (HP:0009773)1.74205283
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.73477910
93Cleft eyelid (HP:0000625)1.73261719
94Abnormality of T cells (HP:0002843)1.72506365
95Abnormality of T cell physiology (HP:0011840)1.72504845
96Abnormality of alanine metabolism (HP:0010916)1.72003921
97Hyperalaninemia (HP:0003348)1.72003921
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72003921
99Abnormal respiratory motile cilium physiology (HP:0012261)1.69397613
100Asplenia (HP:0001746)1.67383773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.57342294
2NUAK13.39817426
3BMPR23.13314710
4MAP3K123.11656408
5MAP4K22.89308121
6CDK192.82836578
7TLK12.73375363
8FRK2.47824623
9ADRBK22.22909281
10TAOK32.15770088
11ZAK2.10524166
12STK162.07092930
13GRK12.06102693
14MST42.00608875
15TEC1.99337071
16MAP4K11.98847170
17WNK41.95494970
18WNK31.73501899
19MYLK1.63789941
20DYRK21.58362611
21ITK1.56919100
22SCYL21.53130266
23OXSR11.47155150
24NME11.44084124
25KIT1.39177931
26EIF2AK31.38831939
27IKBKB1.32167054
28BTK1.30133717
29PINK11.29021760
30FES1.27182742
31BMPR1B1.07578822
32TIE11.05517483
33MUSK1.05236007
34PIK3CA1.05035793
35ERBB30.97875214
36LYN0.94110233
37GRK60.91973364
38PAK30.90836202
39SYK0.90007411
40CSF1R0.87773212
41FLT30.87442328
42INSRR0.80897268
43BCKDK0.80580473
44PHKG10.74303454
45PHKG20.74303454
46TRPM70.71398766
47PNCK0.70291578
48DAPK30.70231580
49ADRBK10.69896085
50WNK10.66587960
51VRK20.66328275
52ILK0.66062552
53DAPK10.65914517
54PLK40.65877573
55NME20.65807832
56EIF2AK20.65623995
57DAPK20.65384538
58MAP3K40.64745206
59OBSCN0.61650261
60PRKCE0.60343927
61LCK0.59534527
62VRK10.59367640
63CDC70.58406289
64STK390.57682065
65IKBKE0.57356078
66LRRK20.54616460
67NEK10.51511132
68RPS6KA50.49919748
69AURKB0.49725738
70EIF2AK10.49548749
71CSNK2A20.47753021
72IGF1R0.47280603
73MARK30.46638019
74IRAK40.46046060
75PRKACA0.45454570
76CSNK1G20.45102089
77PRKCG0.44307966
78MINK10.43395264
79CSNK1G30.42892728
80ZAP700.42371878
81ATR0.42116484
82HCK0.41559382
83PASK0.41016017
84PRKCQ0.39879609
85CSNK1A10.39814125
86CCNB10.39414631
87CSNK1G10.37511177
88STK38L0.36650802
89MATK0.36513942
90CSNK1A1L0.35083652
91ABL10.35019452
92MAP2K60.33914474
93PRKCA0.33740409
94CSNK2A10.33388875
95MAPKAPK50.32906657
96PRKG10.32636590
97MAPK130.32166855
98TNIK0.32108276
99PRKCI0.31219299
100PIM10.31081677

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.10406493
2Ribosome_Homo sapiens_hsa030104.10551421
3Allograft rejection_Homo sapiens_hsa053303.67315895
4Oxidative phosphorylation_Homo sapiens_hsa001903.61389658
5Autoimmune thyroid disease_Homo sapiens_hsa053203.47914128
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.44286866
7Graft-versus-host disease_Homo sapiens_hsa053323.06045523
8Parkinsons disease_Homo sapiens_hsa050122.95731528
9Type I diabetes mellitus_Homo sapiens_hsa049402.77902035
10Proteasome_Homo sapiens_hsa030502.45932721
11Protein export_Homo sapiens_hsa030602.45577987
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15572428
13Cardiac muscle contraction_Homo sapiens_hsa042602.06129599
14Alzheimers disease_Homo sapiens_hsa050101.96884560
15Huntingtons disease_Homo sapiens_hsa050161.87565759
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83778127
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70786323
18Homologous recombination_Homo sapiens_hsa034401.70033286
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56171123
20Antigen processing and presentation_Homo sapiens_hsa046121.52563800
21Rheumatoid arthritis_Homo sapiens_hsa053231.46635156
22Linoleic acid metabolism_Homo sapiens_hsa005911.36579128
23Primary immunodeficiency_Homo sapiens_hsa053401.33693056
24Viral myocarditis_Homo sapiens_hsa054161.32920515
25RNA polymerase_Homo sapiens_hsa030201.32154543
26RNA degradation_Homo sapiens_hsa030181.24296628
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18929210
28Staphylococcus aureus infection_Homo sapiens_hsa051501.18660918
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17610296
30One carbon pool by folate_Homo sapiens_hsa006701.09072417
31Fanconi anemia pathway_Homo sapiens_hsa034601.07534895
32Basal transcription factors_Homo sapiens_hsa030221.06401592
33Phototransduction_Homo sapiens_hsa047441.03876531
34Leishmaniasis_Homo sapiens_hsa051400.92735551
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92040569
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86647335
37Caffeine metabolism_Homo sapiens_hsa002320.84366131
38Nitrogen metabolism_Homo sapiens_hsa009100.82527476
39Propanoate metabolism_Homo sapiens_hsa006400.81272615
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81051100
41Nucleotide excision repair_Homo sapiens_hsa034200.79770854
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78751056
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78029886
44Systemic lupus erythematosus_Homo sapiens_hsa053220.77026902
45Hematopoietic cell lineage_Homo sapiens_hsa046400.73058176
46Regulation of autophagy_Homo sapiens_hsa041400.72272669
47Tryptophan metabolism_Homo sapiens_hsa003800.72013790
48Chemical carcinogenesis_Homo sapiens_hsa052040.71109336
49Collecting duct acid secretion_Homo sapiens_hsa049660.70166072
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67397478
51Spliceosome_Homo sapiens_hsa030400.66101466
52Arachidonic acid metabolism_Homo sapiens_hsa005900.64165389
53Peroxisome_Homo sapiens_hsa041460.63063415
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62785187
55Ether lipid metabolism_Homo sapiens_hsa005650.61519756
56Nicotine addiction_Homo sapiens_hsa050330.61469337
57RNA transport_Homo sapiens_hsa030130.59574506
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59515711
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58213681
60Mismatch repair_Homo sapiens_hsa034300.57696045
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57184179
62Purine metabolism_Homo sapiens_hsa002300.56653014
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.55527868
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.52607539
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50100271
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.47896284
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47577565
68Olfactory transduction_Homo sapiens_hsa047400.47440916
69Pyrimidine metabolism_Homo sapiens_hsa002400.47059812
70Metabolic pathways_Homo sapiens_hsa011000.45461186
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.44557355
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.43852347
73Butanoate metabolism_Homo sapiens_hsa006500.41812160
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40970904
75Retinol metabolism_Homo sapiens_hsa008300.38969332
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36207348
77Sulfur metabolism_Homo sapiens_hsa009200.35063174
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34820395
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34331124
80Taste transduction_Homo sapiens_hsa047420.32482597
81Fat digestion and absorption_Homo sapiens_hsa049750.31978015
82Morphine addiction_Homo sapiens_hsa050320.31927001
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30189506
84Herpes simplex infection_Homo sapiens_hsa051680.27229571
85beta-Alanine metabolism_Homo sapiens_hsa004100.26767542
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26714745
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25524470
88Toxoplasmosis_Homo sapiens_hsa051450.24854026
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.23982872
90Fatty acid degradation_Homo sapiens_hsa000710.23860190
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23261629
92Tuberculosis_Homo sapiens_hsa051520.23252715
93Salivary secretion_Homo sapiens_hsa049700.22968745
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22251827
95GABAergic synapse_Homo sapiens_hsa047270.20833344
96Phagosome_Homo sapiens_hsa041450.19176042
97Serotonergic synapse_Homo sapiens_hsa047260.18962839
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.17657233
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17592812
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15305332

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