ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.29654225
2	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	5.28000494
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.23527275
4	GTP biosynthetic process (GO:0006183)	4.10964926
5	T-helper cell differentiation (GO:0042093)	4.03523602
6	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	4.03523602
7	response to pheromone (GO:0019236)	3.98015468
8	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.93410436
9	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.93410436
10	isotype switching (GO:0045190)	3.93410436
11	regulation of hypersensitivity (GO:0002883)	3.91375533
12	positive regulation of interleukin-12 production (GO:0032735)	3.81717452
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.81615670
14	ATP synthesis coupled proton transport (GO:0015986)	3.81615670
15	T cell differentiation involved in immune response (GO:0002292)	3.81336573
16	alpha-beta T cell differentiation involved in immune response (GO:0002293)	3.81336573
17	alpha-beta T cell activation involved in immune response (GO:0002287)	3.81336573
18	UTP biosynthetic process (GO:0006228)	3.68565485
19	tryptophan metabolic process (GO:0006568)	3.55975204
20	indolalkylamine metabolic process (GO:0006586)	3.47757713
21	maturation of 5.8S rRNA (GO:0000460)	3.43861712
22	rRNA modification (GO:0000154)	3.37799440
23	regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)	3.36495792
24	UTP metabolic process (GO:0046051)	3.31814246
25	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.31681583
26	regulation of immunoglobulin secretion (GO:0051023)	3.31000721
27	proteasome assembly (GO:0043248)	3.29412896
28	regulation of chronic inflammatory response (GO:0002676)	3.28347084
29	histamine secretion (GO:0001821)	3.26742474
30	positive regulation of immunoglobulin mediated immune response (GO:0002891)	3.25922897
31	positive regulation of B cell mediated immunity (GO:0002714)	3.25922897
32	regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)	3.22647444
33	rRNA methylation (GO:0031167)	3.19647004
34	positive regulation of cell fate commitment (GO:0010455)	3.18114384
35	cellular response to exogenous dsRNA (GO:0071360)	3.11896932
36	regulation of inflammatory response to antigenic stimulus (GO:0002861)	3.11842452
37	regulation of germinal center formation (GO:0002634)	3.11550043
38	ribosomal large subunit biogenesis (GO:0042273)	3.09475018
39	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.09199867
40	positive regulation of defense response to virus by host (GO:0002230)	3.04840424
41	regulation of interleukin-12 production (GO:0032655)	3.03883537
42	cytidine deamination (GO:0009972)	3.02935291
43	cytidine metabolic process (GO:0046087)	3.02935291
44	cytidine catabolic process (GO:0006216)	3.02935291
45	ribosomal small subunit assembly (GO:0000028)	3.02563035
46	embryonic hemopoiesis (GO:0035162)	2.99435056
47	regulation of thymocyte apoptotic process (GO:0070243)	2.98189460
48	acrosome reaction (GO:0007340)	2.97503449
49	protein polyglutamylation (GO:0018095)	2.96156844
50	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.96148603
51	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.95559902
52	microtubule severing (GO:0051013)	2.95139901
53	nucleotide transmembrane transport (GO:1901679)	2.91919806
54	protein neddylation (GO:0045116)	2.91126433
55	positive regulation of interleukin-10 production (GO:0032733)	2.88855357
56	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.87584486
57	positive regulation of T cell migration (GO:2000406)	2.86772673
58	viral transcription (GO:0019083)	2.83646683
59	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.83327608
60	positive regulation of T-helper 1 type immune response (GO:0002827)	2.82504037
61	DNA damage response, detection of DNA damage (GO:0042769)	2.82328380
62	B cell activation involved in immune response (GO:0002312)	2.82175256
63	piRNA metabolic process (GO:0034587)	2.81592708
64	somatic diversification of immunoglobulins (GO:0016445)	2.80997492
65	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.79960386
66	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.79382151
67	negative regulation of T-helper cell differentiation (GO:0045623)	2.79382151
68	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.76742524
69	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.74795797
70	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.74308296
71	fucose catabolic process (GO:0019317)	2.73688048
72	L-fucose metabolic process (GO:0042354)	2.73688048
73	L-fucose catabolic process (GO:0042355)	2.73688048
74	positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)	2.70902202
75	establishment of protein localization to Golgi (GO:0072600)	2.70477503
76	protein targeting to Golgi (GO:0000042)	2.70196707
77	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.69865241
78	positive regulation of DNA recombination (GO:0045911)	2.69709130
79	norepinephrine metabolic process (GO:0042415)	2.69510038
80	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.67917235
81	translational termination (GO:0006415)	2.66956604
82	negative regulation of T cell differentiation in thymus (GO:0033085)	2.65768016
83	positive regulation of lymphocyte migration (GO:2000403)	2.65420721
84	axoneme assembly (GO:0035082)	2.65127387
85	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.62971165
86	positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)	2.62471271
87	CD4-positive, alpha-beta T cell differentiation (GO:0043367)	2.62414823
88	lymphocyte activation involved in immune response (GO:0002285)	2.61405989
89	rRNA metabolic process (GO:0016072)	2.60942367
90	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.60699019
91	nucleoside diphosphate phosphorylation (GO:0006165)	2.60436540
92	alpha-beta T cell differentiation (GO:0046632)	2.60244274
93	regulation of alpha-beta T cell differentiation (GO:0046637)	2.59800442
94	cotranslational protein targeting to membrane (GO:0006613)	2.58980898
95	rRNA processing (GO:0006364)	2.58814011
96	protein targeting to ER (GO:0045047)	2.57395784
97	regulation of memory T cell differentiation (GO:0043380)	2.55296708
98	regulation of interleukin-4 production (GO:0032673)	2.55233093
99	protein complex biogenesis (GO:0070271)	2.54132725
100	regulation of T-helper cell differentiation (GO:0045622)	2.53473109

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.77585571
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.19157041
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.15025148
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.02526082
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.87946025
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.73402256
7	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.67691461
8	VDR_22108803_ChIP-Seq_LS180_Human	2.48583732
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.47350550
10	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.41447072
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.38284125
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.37087096
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.29437277
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.25162214
15	EWS_26573619_Chip-Seq_HEK293_Human	2.16511124
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.14353608
17	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.13465662
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.12164661
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.98221117
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.96124665
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.95988273
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.94814623
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.86973149
24	RUNX_20019798_ChIP-Seq_JUKART_Human	1.79719647
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.76288922
26	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.75811172
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.61079748
28	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.61048404
29	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.61048404
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.57431364
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.57388521
32	GATA3_26560356_Chip-Seq_TH2_Human	1.56486317
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53026664
34	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.51735964
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.51377482
36	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.51229974
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51229974
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.49649371
39	P300_19829295_ChIP-Seq_ESCs_Human	1.47255018
40	FUS_26573619_Chip-Seq_HEK293_Human	1.43681979
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43304111
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43304111
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42855650
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42305023
45	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.40933588
46	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.39876501
47	MYB_26560356_Chip-Seq_TH2_Human	1.39293179
48	SMRT_27268052_Chip-Seq_Bcells_Human	1.38229897
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.36588780
50	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.31580494
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30151825
52	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.24326598
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24076818
54	RBPJ_21746931_ChIP-Seq_IB4_Human	1.23280991
55	TTF2_22483619_ChIP-Seq_HELA_Human	1.21532707
56	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.21494059
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20844225
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.20699586
59	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.19650968
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19052855
61	PHF8_20622853_ChIP-Seq_HELA_Human	1.18229439
62	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.18221365
63	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.17692423
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.17293595
65	GBX2_23144817_ChIP-Seq_PC3_Human	1.17061847
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.16289970
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15775885
68	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.15528216
69	GATA3_26560356_Chip-Seq_TH1_Human	1.15140898
70	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.14906512
71	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10875064
72	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10517423
73	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10165725
74	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.09279922
75	NCOR_22424771_ChIP-Seq_293T_Human	1.09082523
76	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.08846931
77	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.07804485
78	ERG_20517297_ChIP-Seq_VCAP_Human	1.06952362
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06824396
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06309165
81	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.05362733
82	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.04391505
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03230206
84	ERA_21632823_ChIP-Seq_H3396_Human	1.03117661
85	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02553639
86	ETV1_20927104_ChIP-Seq_GIST48_Human	1.02308087
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01430713
88	GATA3_27048872_Chip-Seq_THYMUS_Human	1.01314566
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.99372413
90	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.99302178
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.98646105
92	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.96311895
93	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.95702152
94	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.95568346
95	CBP_20019798_ChIP-Seq_JUKART_Human	0.95568346
96	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94130505
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.93058172
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92449869
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.90169302
100	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.89504562

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.63411126
2	MP0000685_abnormal_immune_system	3.38680593
3	MP0002148_abnormal_hypersensitivity_rea	3.01608362
4	MP0005671_abnormal_response_to	2.98308177
5	MP0003195_calcinosis	2.93422355
6	MP0001790_abnormal_immune_system	2.80812759
7	MP0005387_immune_system_phenotype	2.80812759
8	MP0004742_abnormal_vestibular_system	2.72374142
9	MP0009697_abnormal_copulation	2.68619109
10	MP0008875_abnormal_xenobiotic_pharmacok	2.63890834
11	MP0002102_abnormal_ear_morphology	2.61611182
12	MP0009785_altered_susceptibility_to	2.58899413
13	MP0005171_absent_coat_pigmentation	2.58187257
14	MP0000372_irregular_coat_pigmentation	2.46533614
15	MP0001800_abnormal_humoral_immune	2.37755912
16	MP0009764_decreased_sensitivity_to	2.32816450
17	MP0008877_abnormal_DNA_methylation	2.23748990
18	MP0003646_muscle_fatigue	2.13730619
19	MP0006082_CNS_inflammation	2.03160404
20	MP0005000_abnormal_immune_tolerance	1.96264208
21	MP0005377_hearing/vestibular/ear_phenot	1.93484131
22	MP0003878_abnormal_ear_physiology	1.93484131
23	MP0002166_altered_tumor_susceptibility	1.92375025
24	MP0002723_abnormal_immune_serum	1.91633869
25	MP0001873_stomach_inflammation	1.91275139
26	MP0008872_abnormal_physiological_respon	1.88995905
27	MP0000427_abnormal_hair_cycle	1.88634089
28	MP0004381_abnormal_hair_follicle	1.83736788
29	MP0001501_abnormal_sleep_pattern	1.74157268
30	MP0002006_tumorigenesis	1.68747651
31	MP0002452_abnormal_antigen_presenting	1.67242850
32	MP0004885_abnormal_endolymph	1.67021101
33	MP0005410_abnormal_fertilization	1.64284775
34	MP0005167_abnormal_blood-brain_barrier	1.57414579
35	MP0005025_abnormal_response_to	1.57207388
36	MP0002138_abnormal_hepatobiliary_system	1.49506483
37	MP0001348_abnormal_lacrimal_gland	1.49135254
38	MP0002420_abnormal_adaptive_immunity	1.47428886
39	MP0001819_abnormal_immune_cell	1.46994914
40	MP0003011_delayed_dark_adaptation	1.39169201
41	MP0009333_abnormal_splenocyte_physiolog	1.38228812
42	MP0002163_abnormal_gland_morphology	1.38013708
43	MP0003436_decreased_susceptibility_to	1.37132243
44	MP0003718_maternal_effect	1.37088797
45	MP0003329_amyloid_beta_deposits	1.25805248
46	MP0003806_abnormal_nucleotide_metabolis	1.21936983
47	MP0004484_altered_response_of	1.18644173
48	MP0005645_abnormal_hypothalamus_physiol	1.13669883
49	MP0001968_abnormal_touch/_nociception	1.13123728
50	MP0003763_abnormal_thymus_physiology	1.10432209
51	MP0008007_abnormal_cellular_replicative	1.10417696
52	MP0002398_abnormal_bone_marrow	1.07896156
53	MP0000716_abnormal_immune_system	1.07875531
54	MP0005310_abnormal_salivary_gland	1.07333677
55	MP0005636_abnormal_mineral_homeostasis	1.03808139
56	MP0002653_abnormal_ependyma_morphology	1.03676476
57	MP0005551_abnormal_eye_electrophysiolog	1.01500597
58	MP0009745_abnormal_behavioral_response	0.99619663
59	MP0002277_abnormal_respiratory_mucosa	0.99143531
60	MP0005379_endocrine/exocrine_gland_phen	0.98887392
61	MP0000569_abnormal_digit_pigmentation	0.96332625
62	MP0002419_abnormal_innate_immunity	0.95101712
63	MP0002876_abnormal_thyroid_physiology	0.95006563
64	MP0003724_increased_susceptibility_to	0.91899347
65	MP0005075_abnormal_melanosome_morpholog	0.89013724
66	MP0001845_abnormal_inflammatory_respons	0.88500724
67	MP0000604_amyloidosis	0.86949010
68	MP0010155_abnormal_intestine_physiology	0.84928841
69	MP0006276_abnormal_autonomic_nervous	0.84117099
70	MP0004142_abnormal_muscle_tone	0.83437385
71	MP0000383_abnormal_hair_follicle	0.82912023
72	MP0005083_abnormal_biliary_tract	0.82606968
73	MP0001765_abnormal_ion_homeostasis	0.82436437
74	MP0005332_abnormal_amino_acid	0.80138196
75	MP0001486_abnormal_startle_reflex	0.78917734
76	MP0002429_abnormal_blood_cell	0.78343374
77	MP0001533_abnormal_skeleton_physiology	0.77412664
78	MP0000689_abnormal_spleen_morphology	0.76748549
79	MP0001986_abnormal_taste_sensitivity	0.76572043
80	MP0003638_abnormal_response/metabolism_	0.76045605
81	MP0008057_abnormal_DNA_replication	0.75764973
82	MP0008469_abnormal_protein_level	0.75291294
83	MP0004133_heterotaxia	0.74136284
84	MP0000371_diluted_coat_color	0.73722555
85	MP0002405_respiratory_system_inflammati	0.73327489
86	MP0005164_abnormal_response_to	0.71849001
87	MP0003567_abnormal_fetal_cardiomyocyte	0.71384754
88	MP0003186_abnormal_redox_activity	0.68989796
89	MP0005165_increased_susceptibility_to	0.67914598
90	MP0005166_decreased_susceptibility_to	0.67357824
91	MP0002722_abnormal_immune_system	0.64301306
92	MP0004019_abnormal_vitamin_homeostasis	0.62786700
93	MP0001663_abnormal_digestive_system	0.61114529
94	MP0001485_abnormal_pinna_reflex	0.61015142
95	MP0002736_abnormal_nociception_after	0.60549745
96	MP0000703_abnormal_thymus_morphology	0.60427039
97	MP0003786_premature_aging	0.60172416
98	MP0004145_abnormal_muscle_electrophysio	0.57410927
99	MP0003866_abnormal_defecation	0.57186745
100	MP0002837_dystrophic_cardiac_calcinosis	0.56702321

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	8.44482198
2	Increased IgM level (HP:0003496)	5.14977857
3	Elevated erythrocyte sedimentation rate (HP:0003565)	4.07177822
4	Acute necrotizing encephalopathy (HP:0006965)	3.66690710
5	Myositis (HP:0100614)	3.50643730
6	IgG deficiency (HP:0004315)	3.45673647
7	Abnormality of the renal cortex (HP:0011035)	3.37462576
8	Gastrointestinal infarctions (HP:0005244)	3.32428071
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.20984440
10	Hypothermia (HP:0002045)	3.16345168
11	Acute encephalopathy (HP:0006846)	3.09993850
12	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.05838264
13	Progressive macrocephaly (HP:0004481)	3.02479052
14	Optic neuritis (HP:0100653)	2.99785812
15	Retrobulbar optic neuritis (HP:0100654)	2.99785812
16	Methylmalonic acidemia (HP:0002912)	2.95467129
17	Orchitis (HP:0100796)	2.90219701
18	Increased CSF lactate (HP:0002490)	2.90076565
19	Pancreatic cysts (HP:0001737)	2.89136701
20	Mitochondrial inheritance (HP:0001427)	2.85425439
21	Congenital stationary night blindness (HP:0007642)	2.76045113
22	Renal cortical cysts (HP:0000803)	2.70642813
23	Abnormality of T cell physiology (HP:0011840)	2.66416931
24	Lipid accumulation in hepatocytes (HP:0006561)	2.65916552
25	Abolished electroretinogram (ERG) (HP:0000550)	2.65584409
26	Stenosis of the external auditory canal (HP:0000402)	2.65421570
27	IgA deficiency (HP:0002720)	2.65384979
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.64881340
29	B lymphocytopenia (HP:0010976)	2.64553063
30	Pendular nystagmus (HP:0012043)	2.63618829
31	Methylmalonic aciduria (HP:0012120)	2.62036468
32	Congenital, generalized hypertrichosis (HP:0004540)	2.58704389
33	Abnormality of B cell number (HP:0010975)	2.55062232
34	Cleft eyelid (HP:0000625)	2.52323331
35	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.50177964
36	Abnormality of alanine metabolism (HP:0010916)	2.50177964
37	Hyperalaninemia (HP:0003348)	2.50177964
38	Metabolic alkalosis (HP:0200114)	2.46561294
39	Hypoproteinemia (HP:0003075)	2.44973899
40	Increased hepatocellular lipid droplets (HP:0006565)	2.44185542
41	Exertional dyspnea (HP:0002875)	2.42650136
42	Increased serum lactate (HP:0002151)	2.42069749
43	Optic disc pallor (HP:0000543)	2.38374576
44	Polyuria (HP:0000103)	2.38101636
45	Abnormality of T cells (HP:0002843)	2.36792676
46	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.35309109
47	Hypokalemic alkalosis (HP:0001949)	2.33648936
48	Abnormal number of erythroid precursors (HP:0012131)	2.32547761
49	Hepatocellular necrosis (HP:0001404)	2.31639173
50	Abnormality of cells of the erythroid lineage (HP:0012130)	2.31112093
51	Chronic diarrhea (HP:0002028)	2.28701754
52	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.27663579
53	Molar tooth sign on MRI (HP:0002419)	2.27383221
54	Abnormality of midbrain morphology (HP:0002418)	2.27383221
55	Abnormality of the prostate (HP:0008775)	2.25653913
56	Abnormal drinking behavior (HP:0030082)	2.20967517
57	Polydipsia (HP:0001959)	2.20967517
58	Cerebral edema (HP:0002181)	2.20070263
59	3-Methylglutaconic aciduria (HP:0003535)	2.19797842
60	Woolly hair (HP:0002224)	2.17751789
61	Neutropenia (HP:0001875)	2.15654821
62	Leukodystrophy (HP:0002415)	2.11619407
63	Spontaneous hematomas (HP:0007420)	2.10835374
64	Abnormality of vitamin B metabolism (HP:0004340)	2.08922729
65	Attenuation of retinal blood vessels (HP:0007843)	2.08430716
66	Nephronophthisis (HP:0000090)	2.06274716
67	Reticulocytopenia (HP:0001896)	2.03920932
68	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.02271717
69	Absent/shortened dynein arms (HP:0200106)	2.02271717
70	Amaurosis fugax (HP:0100576)	2.01349716
71	Renal Fanconi syndrome (HP:0001994)	2.00527753
72	Abnormality of the renal medulla (HP:0100957)	2.00310890
73	Tubular atrophy (HP:0000092)	2.00296793
74	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00184951
75	Supernumerary bones of the axial skeleton (HP:0009144)	1.98828564
76	Increased intramyocellular lipid droplets (HP:0012240)	1.98374951
77	Anorexia (HP:0002039)	1.97642994
78	Hemoptysis (HP:0002105)	1.97454649
79	Abnormal urine output (HP:0012590)	1.96941644
80	Scotoma (HP:0000575)	1.95900937
81	Hepatic necrosis (HP:0002605)	1.93740918
82	Encephalitis (HP:0002383)	1.93073074
83	Hypoplasia of the radius (HP:0002984)	1.90901048
84	Pancreatic fibrosis (HP:0100732)	1.89434308
85	Abnormality of T cell number (HP:0011839)	1.88418423
86	Conical tooth (HP:0000698)	1.87381301
87	Inability to walk (HP:0002540)	1.87208235
88	Central scotoma (HP:0000603)	1.87023858
89	Gangrene (HP:0100758)	1.86003497
90	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.85894499
91	Decreased central vision (HP:0007663)	1.84531966
92	Increased muscle lipid content (HP:0009058)	1.83735456
93	Decreased circulating renin level (HP:0003351)	1.83293897
94	Progressive inability to walk (HP:0002505)	1.81527854
95	Colon cancer (HP:0003003)	1.81446884
96	Abnormality of renal excretion (HP:0011036)	1.81305994
97	Keratoconjunctivitis (HP:0001096)	1.80499689
98	Keratoconjunctivitis sicca (HP:0001097)	1.80335238
99	Spinal muscular atrophy (HP:0007269)	1.79795525
100	Abnormality of methionine metabolism (HP:0010901)	1.78263162

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.62118837
2	MAP4K1	4.62170257
3	MAP4K2	2.71103501
4	MST4	2.60007151
5	TSSK6	2.41600589
6	MUSK	2.38457453
7	MAP2K6	2.37556341
8	ADRBK2	2.36346368
9	NME1	2.21009842
10	IKBKB	2.16806213
11	GRK1	2.06176863
12	TAOK3	1.94659106
13	MAPKAPK3	1.92852263
14	OXSR1	1.88944114
15	TAF1	1.79578743
16	NUAK1	1.78677120
17	CAMK1D	1.71993159
18	ITK	1.66467309
19	PASK	1.65968445
20	TEC	1.64359118
21	FRK	1.58391177
22	CDK19	1.56073103
23	CAMK1G	1.47558130
24	ZAK	1.36364697
25	BTK	1.31194431
26	TLK1	1.30029426
27	IRAK1	1.24274605
28	NLK	1.20812902
29	MAP3K14	1.20772827
30	BMPR2	1.15795933
31	JAK3	1.15189014
32	DYRK2	1.14575350
33	TIE1	1.13147511
34	MAPKAPK5	1.08505252
35	MAP3K12	1.07999092
36	CAMK1	1.06937975
37	TRIM28	1.04149349
38	INSRR	1.02186568
39	CHUK	1.01717083
40	BMPR1B	0.99002589
41	PINK1	0.98445874
42	WNK3	0.98046676
43	IKBKE	0.96186330
44	PLK4	0.90730458
45	DMPK	0.87312015
46	VRK2	0.86179193
47	DAPK1	0.86059833
48	RPS6KA5	0.81396600
49	MKNK1	0.80739550
50	SYK	0.80224845
51	DAPK2	0.79557841
52	OBSCN	0.76441476
53	WNK4	0.75244320
54	EIF2AK2	0.74714559
55	SIK3	0.74414736
56	TGFBR1	0.73542070
57	LYN	0.73518618
58	EIF2AK3	0.73437050
59	CAMK4	0.70708253
60	LCK	0.70119162
61	STK16	0.69111114
62	CDK8	0.67652470
63	PAK3	0.60887687
64	BCKDK	0.60717584
65	NME2	0.60630730
66	IGF1R	0.58692326
67	NEK1	0.57132646
68	PRKAA2	0.56684104
69	PRKCG	0.56525447
70	VRK1	0.56312197
71	RPS6KB2	0.54228048
72	SRPK1	0.53112085
73	PRKG1	0.53091808
74	PRKCE	0.53066084
75	CSNK1G1	0.53008796
76	ADRBK1	0.52588665
77	PNCK	0.52112541
78	BLK	0.50991571
79	TGFBR2	0.50567835
80	DAPK3	0.50308424
81	PRKCQ	0.50284044
82	MYLK	0.50275250
83	FGFR1	0.50085695
84	ZAP70	0.46506015
85	PIK3CA	0.45762099
86	PRKG2	0.38281041
87	CCNB1	0.37993369
88	CSNK1G3	0.36700141
89	RPS6KA1	0.36483572
90	MAP3K4	0.35704905
91	PAK2	0.35520745
92	PRKCA	0.35476830
93	RPS6KA6	0.34171397
94	CSNK2A2	0.33612724
95	PLK3	0.33506105
96	CSNK1G2	0.33358461
97	CAMK2A	0.32889746
98	GRK7	0.31910883
99	JAK2	0.31836523
100	CSF1R	0.31811584

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.87275612
2	Ribosome_Homo sapiens_hsa03010	3.28205088
3	Allograft rejection_Homo sapiens_hsa05330	3.20918462
4	Proteasome_Homo sapiens_hsa03050	2.96711432
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.90555215
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.90035588
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.73119962
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.43496779
9	Protein export_Homo sapiens_hsa03060	2.35640860
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.25065201
11	RNA degradation_Homo sapiens_hsa03018	2.23290358
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.16807329
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.12255582
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.99402023
15	RNA polymerase_Homo sapiens_hsa03020	1.87780218
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.84851937
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.81734337
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.77525030
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.73084294
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.72297952
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68188456
22	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.67842714
23	Parkinsons disease_Homo sapiens_hsa05012	1.66756052
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62139994
25	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.60147052
26	One carbon pool by folate_Homo sapiens_hsa00670	1.58576623
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.55960397
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.52407459
29	Antigen processing and presentation_Homo sapiens_hsa04612	1.40284085
30	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.33972760
31	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.32304570
32	Rheumatoid arthritis_Homo sapiens_hsa05323	1.29357829
33	Basal transcription factors_Homo sapiens_hsa03022	1.26619348
34	Homologous recombination_Homo sapiens_hsa03440	1.25387858
35	Huntingtons disease_Homo sapiens_hsa05016	1.20804849
36	Caffeine metabolism_Homo sapiens_hsa00232	1.20171955
37	Alzheimers disease_Homo sapiens_hsa05010	1.18332378
38	Viral myocarditis_Homo sapiens_hsa05416	1.16333303
39	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.12242823
40	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.09290690
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.05344862
42	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.02237222
43	Propanoate metabolism_Homo sapiens_hsa00640	0.98386234
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97708286
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92913320
46	RNA transport_Homo sapiens_hsa03013	0.92617133
47	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.87885553
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.84789417
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84516973
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83454969
51	Sulfur metabolism_Homo sapiens_hsa00920	0.82000858
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.80385570
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80326398
54	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79330438
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75066830
56	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.74715388
57	Phototransduction_Homo sapiens_hsa04744	0.70052438
58	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.69514353
59	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.68969022
60	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.67474765
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.67355376
62	Purine metabolism_Homo sapiens_hsa00230	0.63539919
63	Retinol metabolism_Homo sapiens_hsa00830	0.63176072
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60450505
65	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59622213
66	Malaria_Homo sapiens_hsa05144	0.58288559
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56150715
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54758750
69	Legionellosis_Homo sapiens_hsa05134	0.54578463
70	Olfactory transduction_Homo sapiens_hsa04740	0.54329169
71	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.54098749
72	Peroxisome_Homo sapiens_hsa04146	0.51854123
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.50733108
74	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.46350732
75	Butanoate metabolism_Homo sapiens_hsa00650	0.44179863
76	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.43873992
77	Taste transduction_Homo sapiens_hsa04742	0.41786484
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41377541
79	Leishmaniasis_Homo sapiens_hsa05140	0.41361486
80	Measles_Homo sapiens_hsa05162	0.41026898
81	Mismatch repair_Homo sapiens_hsa03430	0.40220988
82	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.40139620
83	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39905359
84	Circadian rhythm_Homo sapiens_hsa04710	0.39642014
85	Regulation of autophagy_Homo sapiens_hsa04140	0.38733127
86	Nicotine addiction_Homo sapiens_hsa05033	0.37642040
87	Metabolic pathways_Homo sapiens_hsa01100	0.36737709
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36320065
89	Spliceosome_Homo sapiens_hsa03040	0.35342794
90	Mineral absorption_Homo sapiens_hsa04978	0.34931651
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34264625
92	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.33731575
93	Morphine addiction_Homo sapiens_hsa05032	0.32305176
94	African trypanosomiasis_Homo sapiens_hsa05143	0.31306559
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31038297
96	TNF signaling pathway_Homo sapiens_hsa04668	0.28575995
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27107778
98	Serotonergic synapse_Homo sapiens_hsa04726	0.25608218
99	Fanconi anemia pathway_Homo sapiens_hsa03460	0.23609343
100	Arginine biosynthesis_Homo sapiens_hsa00220	0.23565839

RPL21P50

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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