ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.76174128
2	cilium or flagellum-dependent cell motility (GO:0001539)	7.71819776
3	positive regulation of male gonad development (GO:2000020)	7.61826312
4	cilium movement (GO:0003341)	6.55966128
5	regulation of male gonad development (GO:2000018)	6.27212334
6	epithelial cilium movement (GO:0003351)	5.87117238
7	substrate-independent telencephalic tangential migration (GO:0021826)	5.67605830
8	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	5.67605830
9	DNA integration (GO:0015074)	5.64776197
10	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	5.52102803
11	axonemal dynein complex assembly (GO:0070286)	5.50129550
12	retinal rod cell development (GO:0046548)	5.49613361
13	peristalsis (GO:0030432)	5.27519652
14	axoneme assembly (GO:0035082)	5.15815795
15	retinal ganglion cell axon guidance (GO:0031290)	4.99595826
16	dopamine transport (GO:0015872)	4.92123725
17	phasic smooth muscle contraction (GO:0014821)	4.88497093
18	axon extension involved in axon guidance (GO:0048846)	4.71512190
19	neuron projection extension involved in neuron projection guidance (GO:1902284)	4.71512190
20	lens fiber cell development (GO:0070307)	4.68676999
21	cell proliferation in forebrain (GO:0021846)	4.64262709
22	male sex determination (GO:0030238)	4.63989715
23	transmission of nerve impulse (GO:0019226)	4.58309600
24	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	4.57978573
25	response to pheromone (GO:0019236)	4.42988855
26	negative regulation of axon guidance (GO:1902668)	4.26225021
27	retinal cone cell development (GO:0046549)	4.22825859
28	motile cilium assembly (GO:0044458)	4.21819892
29	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	4.08062119
30	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	4.08062119
31	cerebellar granule cell differentiation (GO:0021707)	4.05709424
32	positive regulation of synapse assembly (GO:0051965)	4.04569576
33	adult walking behavior (GO:0007628)	4.03952581
34	establishment of planar polarity (GO:0001736)	3.89992352
35	establishment of tissue polarity (GO:0007164)	3.89992352
36	regulation of neurotransmitter uptake (GO:0051580)	3.83652552
37	dendritic spine morphogenesis (GO:0060997)	3.82698777
38	prepulse inhibition (GO:0060134)	3.82690074
39	behavioral response to cocaine (GO:0048148)	3.80344265
40	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	3.78668488
41	regulation of cilium movement (GO:0003352)	3.69909954
42	striatum development (GO:0021756)	3.68441940
43	ventricular system development (GO:0021591)	3.66125065
44	regulation of fever generation (GO:0031620)	3.65764888
45	mating behavior (GO:0007617)	3.60657012
46	neural precursor cell proliferation (GO:0061351)	3.60626273
47	long term synaptic depression (GO:0060292)	3.59792339
48	astrocyte development (GO:0014002)	3.59131044
49	radial glial cell differentiation (GO:0060019)	3.54686263
50	neuron recognition (GO:0008038)	3.51922184
51	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.50183457
52	ephrin receptor signaling pathway (GO:0048013)	3.49446744
53	cilium organization (GO:0044782)	3.47374228
54	regulation of heat generation (GO:0031650)	3.43861364
55	establishment of protein localization to Golgi (GO:0072600)	3.42598851
56	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.42313558
57	neuron fate determination (GO:0048664)	3.37815179
58	asymmetric protein localization (GO:0008105)	3.34770228
59	maternal behavior (GO:0042711)	3.34286157
60	regulation of penile erection (GO:0060405)	3.30000183
61	nonmotile primary cilium assembly (GO:0035058)	3.25789916
62	cilium assembly (GO:0042384)	3.25249467
63	behavioral fear response (GO:0001662)	3.24146738
64	behavioral defense response (GO:0002209)	3.24146738
65	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.22225131
66	protein polyglutamylation (GO:0018095)	3.21663517
67	catecholamine transport (GO:0051937)	3.20552142
68	regulation of synapse assembly (GO:0051963)	3.20327076
69	synapse assembly (GO:0007416)	3.17189519
70	protein targeting to Golgi (GO:0000042)	3.15730893
71	protein localization to cilium (GO:0061512)	3.13910906
72	tongue development (GO:0043586)	3.11523038
73	establishment of nucleus localization (GO:0040023)	3.11244540
74	presynaptic membrane organization (GO:0097090)	3.08841023
75	stem cell development (GO:0048864)	3.07762610
76	negative regulation of cAMP-mediated signaling (GO:0043951)	3.04959686
77	maturation of 5.8S rRNA (GO:0000460)	3.01348937
78	neuronal stem cell maintenance (GO:0097150)	3.01242237
79	limb bud formation (GO:0060174)	2.97356111
80	nephron epithelium morphogenesis (GO:0072088)	2.95613434
81	nephron tubule morphogenesis (GO:0072078)	2.95613434
82	microtubule bundle formation (GO:0001578)	2.95612905
83	regulation of growth hormone secretion (GO:0060123)	2.95363520
84	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	2.92098444
85	intraciliary transport (GO:0042073)	2.89480854
86	somite development (GO:0061053)	2.88280540
87	protein localization to Golgi apparatus (GO:0034067)	2.86872592
88	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.86542236
89	regulation of timing of cell differentiation (GO:0048505)	2.85570445
90	left/right pattern formation (GO:0060972)	2.84774300
91	parental behavior (GO:0060746)	2.84666767
92	neuronal action potential (GO:0019228)	2.83044833
93	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.82793293
94	cilium morphogenesis (GO:0060271)	2.82347145
95	smoothened signaling pathway (GO:0007224)	2.80265907
96	positive regulation of reproductive process (GO:2000243)	2.80259687
97	regulation of development, heterochronic (GO:0040034)	2.78571512
98	synaptic transmission, dopaminergic (GO:0001963)	2.74934991
99	positive regulation of potassium ion transport (GO:0043268)	2.74833178
100	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.73903987

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.47121222
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.53363701
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.51726481
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.26002869
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.15333619
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.97910318
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.93985072
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.91331347
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.82019524
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.66016396
11	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.64701395
12	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.54156428
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.43247197
14	FUS_26573619_Chip-Seq_HEK293_Human	2.36817461
15	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.20609707
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.05696748
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04865988
18	AR_21572438_ChIP-Seq_LNCaP_Human	2.04453177
19	EWS_26573619_Chip-Seq_HEK293_Human	1.88247751
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86861875
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.86264004
22	P300_19829295_ChIP-Seq_ESCs_Human	1.83252251
23	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.79772637
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.78296051
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.75426212
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.73675257
27	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.67627995
28	STAT3_23295773_ChIP-Seq_U87_Human	1.67578424
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63444639
30	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62652444
31	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62055999
32	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.60116312
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.60115210
34	AR_25329375_ChIP-Seq_VCAP_Human	1.59812221
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57607482
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.51273693
37	TCF4_23295773_ChIP-Seq_U87_Human	1.50245129
38	VDR_22108803_ChIP-Seq_LS180_Human	1.50200574
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.44295166
40	TP53_16413492_ChIP-PET_HCT116_Human	1.42091423
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41981288
42	RUNX2_22187159_ChIP-Seq_PCA_Human	1.39668124
43	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.29794640
44	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.28395634
45	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.27457941
46	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.26657475
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25674933
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.25674933
49	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23883382
50	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23726809
51	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23213876
52	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.22406619
53	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.21760517
54	AHR_22903824_ChIP-Seq_MCF-7_Human	1.21164389
55	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.20899675
56	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.18448376
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18230765
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18230765
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.18009257
60	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.17199655
61	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.17157866
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.16544010
63	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16544010
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16240235
65	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.16233132
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15860795
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15639974
68	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.14344123
69	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.14264405
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13820219
71	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13576503
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.13543774
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.12944008
74	JUN_21703547_ChIP-Seq_K562_Human	1.12632130
75	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.10958785
76	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.10743871
77	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.10205904
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08923606
79	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.08780498
80	REST_21632747_ChIP-Seq_MESCs_Mouse	1.07559102
81	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07469849
82	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.07439769
83	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.07326440
84	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.06771706
85	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.06716654
86	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.06675862
87	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.06640918
88	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.05126317
89	TP53_18474530_ChIP-ChIP_U2OS_Human	1.02437061
90	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.02126951
91	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.99990370
92	KDM2B_26808549_Chip-Seq_REH_Human	0.99455859
93	DROSHA_22980978_ChIP-Seq_HELA_Human	0.99412456
94	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98448962
95	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98095565
96	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.96642434
97	AR_19668381_ChIP-Seq_PC3_Human	0.95586294
98	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.94938333
99	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.94251203
100	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92991134

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	8.98424824
2	MP0003136_yellow_coat_color	5.97427472
3	MP0001529_abnormal_vocalization	2.94011636
4	MP0005171_absent_coat_pigmentation	2.92782152
5	MP0002653_abnormal_ependyma_morphology	2.87249532
6	MP0000566_synostosis	2.35618280
7	MP0004133_heterotaxia	2.31690726
8	MP0000383_abnormal_hair_follicle	2.27166474
9	MP0003122_maternal_imprinting	2.12580907
10	MP0000778_abnormal_nervous_system	2.12310792
11	MP0006292_abnormal_olfactory_placode	2.09952062
12	MP0005253_abnormal_eye_physiology	1.98692108
13	MP0005248_abnormal_Harderian_gland	1.97794104
14	MP0000569_abnormal_digit_pigmentation	1.97202952
15	MP0005174_abnormal_tail_pigmentation	1.96740037
16	MP0001293_anophthalmia	1.96268011
17	MP0008789_abnormal_olfactory_epithelium	1.94263197
18	MP0002751_abnormal_autonomic_nervous	1.87182481
19	MP0002638_abnormal_pupillary_reflex	1.86941771
20	MP0010678_abnormal_skin_adnexa	1.77667285
21	MP0002102_abnormal_ear_morphology	1.77641641
22	MP0006276_abnormal_autonomic_nervous	1.73460299
23	MP0002938_white_spotting	1.72859600
24	MP0005394_taste/olfaction_phenotype	1.70936761
25	MP0005499_abnormal_olfactory_system	1.70936761
26	MP0002009_preneoplasia	1.63439930
27	MP0002234_abnormal_pharynx_morphology	1.60828128
28	MP0005551_abnormal_eye_electrophysiolog	1.55196890
29	MP0000026_abnormal_inner_ear	1.55175204
30	MP0000631_abnormal_neuroendocrine_gland	1.50657911
31	MP0006072_abnormal_retinal_apoptosis	1.45545646
32	MP0001324_abnormal_eye_pigmentation	1.43326820
33	MP0002184_abnormal_innervation	1.40770520
34	MP0009046_muscle_twitch	1.40073566
35	MP0000955_abnormal_spinal_cord	1.39241489
36	MP0004859_abnormal_synaptic_plasticity	1.35622726
37	MP0002233_abnormal_nose_morphology	1.29661932
38	MP0001984_abnormal_olfaction	1.24212010
39	MP0009384_cardiac_valve_regurgitation	1.23742632
40	MP0003937_abnormal_limbs/digits/tail_de	1.22433164
41	MP0005391_vision/eye_phenotype	1.20313915
42	MP0003938_abnormal_ear_development	1.17444881
43	MP0010030_abnormal_orbit_morphology	1.16313015
44	MP0002928_abnormal_bile_duct	1.15726707
45	MP0004145_abnormal_muscle_electrophysio	1.13696777
46	MP0002095_abnormal_skin_pigmentation	1.13586476
47	MP0004043_abnormal_pH_regulation	1.12787597
48	MP0003787_abnormal_imprinting	1.11365550
49	MP0009053_abnormal_anal_canal	1.08780380
50	MP0006054_spinal_hemorrhage	1.08544975
51	MP0002557_abnormal_social/conspecific_i	1.06333973
52	MP0001286_abnormal_eye_development	1.02018489
53	MP0000579_abnormal_nail_morphology	1.01453312
54	MP0001299_abnormal_eye_distance/	1.01171133
55	MP0001486_abnormal_startle_reflex	0.98582560
56	MP0000049_abnormal_middle_ear	0.97668137
57	MP0003635_abnormal_synaptic_transmissio	0.94659662
58	MP0005195_abnormal_posterior_eye	0.94111244
59	MP0002752_abnormal_somatic_nervous	0.89991389
60	MP0003755_abnormal_palate_morphology	0.89479576
61	MP0003861_abnormal_nervous_system	0.88742041
62	MP0003121_genomic_imprinting	0.88652747
63	MP0001346_abnormal_lacrimal_gland	0.86963904
64	MP0004142_abnormal_muscle_tone	0.86029133
65	MP0002116_abnormal_craniofacial_bone	0.80708255
66	MP0002882_abnormal_neuron_morphology	0.80266747
67	MP0002090_abnormal_vision	0.80218196
68	MP0002249_abnormal_larynx_morphology	0.78979477
69	MP0003119_abnormal_digestive_system	0.77072156
70	MP0001963_abnormal_hearing_physiology	0.76848215
71	MP0001340_abnormal_eyelid_morphology	0.76666989
72	MP0009250_abnormal_appendicular_skeleto	0.76026211
73	MP0002067_abnormal_sensory_capabilities	0.75761813
74	MP0002152_abnormal_brain_morphology	0.75027946
75	MP0002177_abnormal_outer_ear	0.73662709
76	MP0003137_abnormal_impulse_conducting	0.72918863
77	MP0001970_abnormal_pain_threshold	0.72911173
78	MP0002572_abnormal_emotion/affect_behav	0.72659313
79	MP0002282_abnormal_trachea_morphology	0.72363419
80	MP0002063_abnormal_learning/memory/cond	0.71876301
81	MP0000427_abnormal_hair_cycle	0.71551825
82	MP0002092_abnormal_eye_morphology	0.71139314
83	MP0001727_abnormal_embryo_implantation	0.70775558
84	MP0003936_abnormal_reproductive_system	0.69352683
85	MP0000428_abnormal_craniofacial_morphol	0.69107209
86	MP0005508_abnormal_skeleton_morphology	0.68647639
87	MP0003690_abnormal_glial_cell	0.68582437
88	MP0004924_abnormal_behavior	0.67672214
89	MP0005386_behavior/neurological_phenoty	0.67672214
90	MP0003935_abnormal_craniofacial_develop	0.66690222
91	MP0004858_abnormal_nervous_system	0.66377357
92	MP0002064_seizures	0.65444485
93	MP0005075_abnormal_melanosome_morpholog	0.63882306
94	MP0002111_abnormal_tail_morphology	0.62727554
95	MP0009745_abnormal_behavioral_response	0.62390535
96	MP0002272_abnormal_nervous_system	0.62247947
97	MP0002735_abnormal_chemical_nociception	0.62171663
98	MP0002822_catalepsy	0.62076569
99	MP0000432_abnormal_head_morphology	0.60803480
100	MP0003632_abnormal_nervous_system	0.59935408

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	6.20637841
2	Hypoplastic pelvis (HP:0008839)	5.88563312
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.22849478
4	Absent/shortened dynein arms (HP:0200106)	5.22849478
5	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.02433110
6	Abnormal ciliary motility (HP:0012262)	4.92543169
7	Abnormal respiratory epithelium morphology (HP:0012253)	4.76885951
8	Abnormal respiratory motile cilium morphology (HP:0005938)	4.76885951
9	Abnormal respiratory motile cilium physiology (HP:0012261)	4.62893709
10	Oligodactyly (hands) (HP:0001180)	4.51591466
11	Abnormal sex determination (HP:0012244)	4.44200090
12	Sex reversal (HP:0012245)	4.44200090
13	Fibular aplasia (HP:0002990)	3.94242613
14	Oligodactyly (HP:0012165)	3.68902456
15	Synostosis involving the elbow (HP:0003938)	3.67594630
16	Humeroradial synostosis (HP:0003041)	3.67594630
17	Pancreatic fibrosis (HP:0100732)	3.55758884
18	Aplasia/hypoplasia of the uterus (HP:0008684)	3.51673671
19	Chronic hepatic failure (HP:0100626)	3.46657946
20	Rhinitis (HP:0012384)	3.44536230
21	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.41993518
22	Chronic bronchitis (HP:0004469)	3.40898850
23	Molar tooth sign on MRI (HP:0002419)	3.31540498
24	Abnormality of midbrain morphology (HP:0002418)	3.31540498
25	Tubulointerstitial nephritis (HP:0001970)	3.19074693
26	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	3.16069625
27	Pancreatic cysts (HP:0001737)	3.13615087
28	Adactyly (HP:0009776)	3.04368425
29	Nephronophthisis (HP:0000090)	3.00739677
30	Medial flaring of the eyebrow (HP:0010747)	2.97513506
31	Cystic liver disease (HP:0006706)	2.83309709
32	Congenital primary aphakia (HP:0007707)	2.82272583
33	Scrotal hypoplasia (HP:0000046)	2.80345748
34	Split foot (HP:0001839)	2.79732966
35	Gait imbalance (HP:0002141)	2.78852141
36	Progressive cerebellar ataxia (HP:0002073)	2.76860567
37	Male pseudohermaphroditism (HP:0000037)	2.67946245
38	Supernumerary spleens (HP:0009799)	2.61780320
39	Polyphagia (HP:0002591)	2.60113728
40	Abnormality of the renal medulla (HP:0100957)	2.59290494
41	Nephrogenic diabetes insipidus (HP:0009806)	2.58058159
42	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.57403186
43	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.56512763
44	Postaxial hand polydactyly (HP:0001162)	2.55711822
45	Abdominal situs inversus (HP:0003363)	2.51105528
46	Abnormality of abdominal situs (HP:0011620)	2.51105528
47	Occipital encephalocele (HP:0002085)	2.50287878
48	Hyperglycinemia (HP:0002154)	2.47443961
49	Gonadal dysgenesis (HP:0000133)	2.44851431
50	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.43332083
51	Barrel-shaped chest (HP:0001552)	2.41158218
52	Genital tract atresia (HP:0001827)	2.39320648
53	Bronchiectasis (HP:0002110)	2.37801589
54	Postaxial foot polydactyly (HP:0001830)	2.36222542
55	Vaginal atresia (HP:0000148)	2.33725823
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.31176379
57	Bifid scrotum (HP:0000048)	2.29857151
58	Albinism (HP:0001022)	2.24309530
59	Abnormality of the pubic bones (HP:0003172)	2.21289394
60	Short foot (HP:0001773)	2.20502835
61	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.18890046
62	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.17001425
63	Abnormal rod and cone electroretinograms (HP:0008323)	2.14540273
64	Renal dysplasia (HP:0000110)	2.13900050
65	Preaxial hand polydactyly (HP:0001177)	2.12877299
66	Type II lissencephaly (HP:0007260)	2.11401299
67	Hemivertebrae (HP:0002937)	2.11311463
68	Sclerocornea (HP:0000647)	2.11245051
69	Anencephaly (HP:0002323)	2.10445421
70	Testicular neoplasm (HP:0010788)	2.08492625
71	Tubular atrophy (HP:0000092)	2.07608696
72	Median cleft lip (HP:0000161)	2.07464957
73	Specific learning disability (HP:0001328)	2.06638484
74	Tubulointerstitial abnormality (HP:0001969)	2.04099968
75	Large for gestational age (HP:0001520)	2.03724439
76	Anophthalmia (HP:0000528)	1.97818752
77	Broad foot (HP:0001769)	1.96173569
78	Neonatal respiratory distress (HP:0002643)	1.95705657
79	Hypoplastic nipples (HP:0002557)	1.93394778
80	Poor coordination (HP:0002370)	1.93181872
81	Bile duct proliferation (HP:0001408)	1.92343771
82	Abnormal biliary tract physiology (HP:0012439)	1.92343771
83	Broad alveolar ridges (HP:0000187)	1.91728240
84	Abnormal finger flexion creases (HP:0006143)	1.91067406
85	Decreased circulating renin level (HP:0003351)	1.90469309
86	Patellar aplasia (HP:0006443)	1.88293894
87	Absent forearm bone (HP:0003953)	1.84422315
88	Aplasia involving forearm bones (HP:0009822)	1.84422315
89	Bony spicule pigmentary retinopathy (HP:0007737)	1.83155209
90	Chronic sinusitis (HP:0011109)	1.82039508
91	Congenital hepatic fibrosis (HP:0002612)	1.81115717
92	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.79285872
93	Cerebellar dysplasia (HP:0007033)	1.79257241
94	Hyperglycinuria (HP:0003108)	1.78544856
95	Blue irides (HP:0000635)	1.76709418
96	Abnormal hair whorl (HP:0010721)	1.74230346
97	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.73497846
98	Congenital stationary night blindness (HP:0007642)	1.71981641
99	Asplenia (HP:0001746)	1.70590791
100	Retinal dysplasia (HP:0007973)	1.70517659

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	4.60008232
2	DYRK3	4.04005546
3	MKNK2	3.80440087
4	EPHB1	3.78867802
5	BMPR1B	3.50289079
6	MKNK1	3.04033362
7	MAPK15	3.00530079
8	EPHA4	2.98697751
9	CASK	2.94505239
10	CDK19	2.94171610
11	WNK3	2.81786542
12	ERBB3	2.52252354
13	MAP3K4	2.15916800
14	STK16	1.90164628
15	MAP2K7	1.81640035
16	FRK	1.70565594
17	EPHA3	1.67376095
18	NUAK1	1.65136791
19	LATS1	1.56943024
20	MARK1	1.50536456
21	NTRK2	1.46172020
22	TGFBR1	1.38842082
23	CAMKK2	1.33641406
24	BRD4	1.32620979
25	TRIM28	1.30897595
26	ERBB2	1.29721951
27	BCR	1.22789766
28	AKT3	1.20879649
29	MST4	1.20355700
30	DYRK2	1.09276329
31	RPS6KA4	0.99696821
32	IRAK1	0.93002270
33	MARK2	0.91552411
34	EPHB2	0.89995234
35	FER	0.88788813
36	DYRK1A	0.88450348
37	LIMK1	0.83957391
38	MAPK13	0.83604522
39	CSNK1G2	0.81970188
40	CSNK1A1L	0.79934303
41	WNK4	0.76537370
42	ZAK	0.76085824
43	BCKDK	0.74953708
44	GRK1	0.73309597
45	MAPK7	0.71494182
46	MAP3K10	0.71190640
47	TAOK3	0.70156327
48	STK38L	0.69044733
49	PRKCE	0.68866616
50	DAPK2	0.64346310
51	DYRK1B	0.63374247
52	CSNK1G3	0.62505519
53	TAOK1	0.60696872
54	PINK1	0.59391529
55	EPHA2	0.56723806
56	PKN1	0.56219147
57	STK11	0.55671384
58	SGK2	0.55186036
59	PNCK	0.53751492
60	MAP3K7	0.51106040
61	CAMK4	0.50358816
62	MAP4K2	0.49409504
63	PAK3	0.49073463
64	PLK1	0.48035286
65	CAMK1	0.46765249
66	PRKCG	0.46542359
67	ADRBK1	0.45645320
68	OXSR1	0.45059737
69	SGK223	0.44371889
70	SGK494	0.44371889
71	BRSK2	0.42033049
72	ADRBK2	0.41297919
73	YES1	0.41128131
74	NEK9	0.40893139
75	CSNK1G1	0.39940342
76	CAMK1G	0.38006269
77	CAMK2A	0.37815958
78	ACVR1B	0.36970412
79	PRKCZ	0.36320995
80	FLT3	0.36233500
81	PRKACA	0.36063787
82	INSRR	0.35454976
83	CHUK	0.34039843
84	CSNK1A1	0.33960025
85	LMTK2	0.33500061
86	FGFR1	0.33163437
87	UHMK1	0.31776491
88	PTK2B	0.31561900
89	PRKAA2	0.31264113
90	BMPR2	0.31158571
91	STK39	0.30828802
92	PRKACB	0.30475665
93	PRKAA1	0.30313719
94	PHKG2	0.30307793
95	PHKG1	0.30307793
96	AKT2	0.30066774
97	CDK5	0.30027446
98	STK3	0.30003897
99	ABL2	0.29964585
100	RPS6KA6	0.29040133

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal cell carcinoma_Homo sapiens_hsa05217	3.44023561
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.81891648
3	Axon guidance_Homo sapiens_hsa04360	2.49835857
4	Regulation of autophagy_Homo sapiens_hsa04140	2.38415597
5	Protein export_Homo sapiens_hsa03060	2.33431352
6	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.29921058
7	Steroid biosynthesis_Homo sapiens_hsa00100	2.29753617
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.25328348
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.22942875
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.12047792
11	Ether lipid metabolism_Homo sapiens_hsa00565	2.04032077
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.01663170
13	Nicotine addiction_Homo sapiens_hsa05033	1.97367424
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.91217663
15	Cocaine addiction_Homo sapiens_hsa05030	1.86199349
16	Propanoate metabolism_Homo sapiens_hsa00640	1.85940947
17	Phototransduction_Homo sapiens_hsa04744	1.82715227
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.82686280
19	Morphine addiction_Homo sapiens_hsa05032	1.81826686
20	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.80977963
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.75563553
22	Basal transcription factors_Homo sapiens_hsa03022	1.71091231
23	Melanogenesis_Homo sapiens_hsa04916	1.63347488
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56325762
25	Hippo signaling pathway_Homo sapiens_hsa04390	1.54441805
26	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.54191530
27	Huntingtons disease_Homo sapiens_hsa05016	1.50832934
28	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.45613048
29	Olfactory transduction_Homo sapiens_hsa04740	1.43888441
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43203401
31	Taste transduction_Homo sapiens_hsa04742	1.32399453
32	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.30795171
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30705479
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25781693
35	Dopaminergic synapse_Homo sapiens_hsa04728	1.25202580
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.24236659
37	Wnt signaling pathway_Homo sapiens_hsa04310	1.23184749
38	Amphetamine addiction_Homo sapiens_hsa05031	1.13051191
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.11492160
40	Insulin secretion_Homo sapiens_hsa04911	1.07561506
41	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.07324225
42	Circadian rhythm_Homo sapiens_hsa04710	1.07279657
43	GABAergic synapse_Homo sapiens_hsa04727	1.05605894
44	Butanoate metabolism_Homo sapiens_hsa00650	1.05601239
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.01790330
46	beta-Alanine metabolism_Homo sapiens_hsa00410	1.01597891
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00243416
48	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99923987
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.97496241
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.95722629
51	Parkinsons disease_Homo sapiens_hsa05012	0.94280453
52	Notch signaling pathway_Homo sapiens_hsa04330	0.90038817
53	Peroxisome_Homo sapiens_hsa04146	0.88953657
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87706394
55	cAMP signaling pathway_Homo sapiens_hsa04024	0.86352186
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.84323354
57	Calcium signaling pathway_Homo sapiens_hsa04020	0.83562293
58	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.83002868
59	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.82771459
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81876100
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.81483333
62	Retinol metabolism_Homo sapiens_hsa00830	0.81462904
63	Tight junction_Homo sapiens_hsa04530	0.80611627
64	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.76555297
65	Circadian entrainment_Homo sapiens_hsa04713	0.75970739
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72502723
67	Renin-angiotensin system_Homo sapiens_hsa04614	0.71875526
68	Caffeine metabolism_Homo sapiens_hsa00232	0.71102224
69	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.69247710
70	ABC transporters_Homo sapiens_hsa02010	0.68175979
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.65208761
72	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.64814955
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62913933
74	Gap junction_Homo sapiens_hsa04540	0.61560519
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.61430917
76	Serotonergic synapse_Homo sapiens_hsa04726	0.55832300
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.52238844
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50606653
79	Alcoholism_Homo sapiens_hsa05034	0.50573152
80	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.48471675
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47231976
82	Ras signaling pathway_Homo sapiens_hsa04014	0.46683559
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46342438
84	Metabolic pathways_Homo sapiens_hsa01100	0.46067314
85	Oxidative phosphorylation_Homo sapiens_hsa00190	0.45551154
86	Pancreatic secretion_Homo sapiens_hsa04972	0.44594009
87	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.40999826
88	Cardiac muscle contraction_Homo sapiens_hsa04260	0.36992748
89	Pathways in cancer_Homo sapiens_hsa05200	0.36169424
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.34206361
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33847142
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33664993
93	Adherens junction_Homo sapiens_hsa04520	0.33306021
94	Rap1 signaling pathway_Homo sapiens_hsa04015	0.31056562
95	RNA degradation_Homo sapiens_hsa03018	0.30965010
96	Sphingolipid metabolism_Homo sapiens_hsa00600	0.29834364
97	MAPK signaling pathway_Homo sapiens_hsa04010	0.29823763
98	Cholinergic synapse_Homo sapiens_hsa04725	0.29118275
99	Renin secretion_Homo sapiens_hsa04924	0.28754267
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28496716

RPL21P54

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »