ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.07836742
2	maturation of SSU-rRNA (GO:0030490)	6.01148352
3	translational termination (GO:0006415)	5.85549356
4	ribosomal small subunit assembly (GO:0000028)	5.26803604
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.22519749
6	cotranslational protein targeting to membrane (GO:0006613)	5.18657300
7	ribosomal small subunit biogenesis (GO:0042274)	5.18233384
8	protein targeting to ER (GO:0045047)	5.15996866
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.08155897
10	ATP synthesis coupled proton transport (GO:0015986)	5.08155897
11	translational elongation (GO:0006414)	4.99512759
12	DNA deamination (GO:0045006)	4.98242270
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.95297266
14	protein localization to endoplasmic reticulum (GO:0070972)	4.85613586
15	chaperone-mediated protein transport (GO:0072321)	4.46547417
16	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.45213760
17	viral life cycle (GO:0019058)	4.42747322
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.42151943
19	protein neddylation (GO:0045116)	4.42117770
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.39922419
21	cellular protein complex disassembly (GO:0043624)	4.33387555
22	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.29822970
23	translational initiation (GO:0006413)	4.02356605
24	translation (GO:0006412)	3.89762132
25	regulation of isotype switching to IgG isotypes (GO:0048302)	3.88531492
26	protein polyglutamylation (GO:0018095)	3.86091104
27	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.84467283
28	protein complex biogenesis (GO:0070271)	3.79217337
29	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.76839555
30	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.76113570
31	respiratory electron transport chain (GO:0022904)	3.75187818
32	electron transport chain (GO:0022900)	3.73757338
33	behavioral response to nicotine (GO:0035095)	3.73050513
34	regulation of immunoglobulin secretion (GO:0051023)	3.72420295
35	ribosomal large subunit biogenesis (GO:0042273)	3.69013946
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.66988339
37	NADH dehydrogenase complex assembly (GO:0010257)	3.66988339
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.66988339
39	regulation of regulatory T cell differentiation (GO:0045589)	3.66841603
40	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.63405994
41	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.63405994
42	protein complex disassembly (GO:0043241)	3.60001256
43	mitochondrial respiratory chain complex assembly (GO:0033108)	3.49965865
44	GTP biosynthetic process (GO:0006183)	3.48904191
45	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.47788627
46	macromolecular complex disassembly (GO:0032984)	3.41935594
47	protein-cofactor linkage (GO:0018065)	3.40657023
48	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.38825566
49	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.36291026
50	cellular component biogenesis (GO:0044085)	3.35262421
51	protein targeting to membrane (GO:0006612)	3.35125095
52	ribonucleoprotein complex biogenesis (GO:0022613)	3.33226248
53	cellular response to interferon-beta (GO:0035458)	3.28743807
54	mRNA catabolic process (GO:0006402)	3.17355484
55	indolalkylamine metabolic process (GO:0006586)	3.11734969
56	cellular ketone body metabolic process (GO:0046950)	3.07360575
57	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.05830602
58	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.05571297
59	gonadal mesoderm development (GO:0007506)	3.02536056
60	inner mitochondrial membrane organization (GO:0007007)	2.99279980
61	maturation of 5.8S rRNA (GO:0000460)	2.97806762
62	RNA catabolic process (GO:0006401)	2.93572508
63	ATP biosynthetic process (GO:0006754)	2.92228416
64	guanosine-containing compound biosynthetic process (GO:1901070)	2.90092094
65	UTP biosynthetic process (GO:0006228)	2.89271267
66	piRNA metabolic process (GO:0034587)	2.88387357
67	activated T cell proliferation (GO:0050798)	2.82285752
68	water-soluble vitamin biosynthetic process (GO:0042364)	2.81843781
69	rRNA processing (GO:0006364)	2.80688496
70	tryptophan metabolic process (GO:0006568)	2.80527344
71	rRNA metabolic process (GO:0016072)	2.78000780
72	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.76771089
73	termination of RNA polymerase III transcription (GO:0006386)	2.76771089
74	kidney morphogenesis (GO:0060993)	2.73827342
75	ketone body metabolic process (GO:1902224)	2.70466966
76	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.70001525
77	endoderm formation (GO:0001706)	2.68123833
78	UTP metabolic process (GO:0046051)	2.67769980
79	pseudouridine synthesis (GO:0001522)	2.66871432
80	hydrogen ion transmembrane transport (GO:1902600)	2.65801867
81	proteasome assembly (GO:0043248)	2.61406502
82	cytidine metabolic process (GO:0046087)	2.59888866
83	cytidine catabolic process (GO:0006216)	2.59888866
84	cytidine deamination (GO:0009972)	2.59888866
85	ribosome biogenesis (GO:0042254)	2.59825235
86	mannosylation (GO:0097502)	2.56938763
87	kynurenine metabolic process (GO:0070189)	2.53707682
88	proton transport (GO:0015992)	2.53441960
89	leukotriene biosynthetic process (GO:0019370)	2.52870437
90	male meiosis I (GO:0007141)	2.51681898
91	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.51617597
92	positive regulation of protein homooligomerization (GO:0032464)	2.51367710
93	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.50982834
94	hydrogen transport (GO:0006818)	2.49644513
95	response to interferon-beta (GO:0035456)	2.48431880
96	axoneme assembly (GO:0035082)	2.48129289
97	detection of light stimulus involved in sensory perception (GO:0050962)	2.47563631
98	detection of light stimulus involved in visual perception (GO:0050908)	2.47563631
99	indolalkylamine catabolic process (GO:0046218)	2.47355684
100	tryptophan catabolic process (GO:0006569)	2.47355684

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.16316382
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.65346800
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.64965101
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.42507564
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.27756172
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.24904445
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.23627664
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.99916323
9	VDR_22108803_ChIP-Seq_LS180_Human	2.59589248
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55504200
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.52188569
12	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.50704951
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.42515504
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.37581862
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37312057
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.30297880
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.16627481
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15049332
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.10952736
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.09416267
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.97658003
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.97543847
23	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.93524726
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.89980326
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.89334257
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.85768375
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.80459130
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.66243099
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65612105
30	EWS_26573619_Chip-Seq_HEK293_Human	1.64382074
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.62115400
32	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.56579879
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.55593111
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.54803311
35	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.49707765
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48191253
37	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.39889324
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.39528107
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38237206
40	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.33485913
41	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.32021300
42	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.30344015
43	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.29394262
44	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.26352130
45	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.26347515
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26180202
47	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.25875990
48	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.24794190
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22057699
50	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21808149
51	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.21322689
52	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.20444153
53	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.20254772
54	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.19494411
55	FUS_26573619_Chip-Seq_HEK293_Human	1.19372369
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18475531
57	GBX2_23144817_ChIP-Seq_PC3_Human	1.17500078
58	XRN2_22483619_ChIP-Seq_HELA_Human	1.12897589
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12813545
60	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.11741962
61	MYC_19829295_ChIP-Seq_ESCs_Human	1.10118216
62	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08620879
63	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08358628
64	P300_19829295_ChIP-Seq_ESCs_Human	1.07015790
65	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.05867556
66	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.05770603
67	AR_20517297_ChIP-Seq_VCAP_Human	1.04938215
68	ERA_21632823_ChIP-Seq_H3396_Human	1.04938140
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04598789
70	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04361812
71	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.03993244
72	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.03100561
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02404143
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02404143
75	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02257457
76	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01510038
77	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01444782
78	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.01135913
79	GABP_19822575_ChIP-Seq_HepG2_Human	0.99631168
80	NCOR_22424771_ChIP-Seq_293T_Human	0.99068800
81	GATA3_26560356_Chip-Seq_TH2_Human	0.95797309
82	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94513195
83	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94513195
84	HTT_18923047_ChIP-ChIP_STHdh_Human	0.93907613
85	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93639889
86	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.93137249
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93116519
88	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.92941835
89	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.92007032
90	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.91628722
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.91163007
92	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90942737
93	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.90604258
94	BCAT_22108803_ChIP-Seq_LS180_Human	0.89531899
95	ERG_20517297_ChIP-Seq_VCAP_Human	0.88771066
96	P53_21459846_ChIP-Seq_SAOS-2_Human	0.88148011
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.87692910
98	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.85958852
99	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.85785276
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.85785276

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.61363106
2	MP0008877_abnormal_DNA_methylation	3.54126674
3	MP0003787_abnormal_imprinting	3.45532568
4	MP0002163_abnormal_gland_morphology	3.27217635
5	MP0002102_abnormal_ear_morphology	3.03199371
6	MP0003123_paternal_imprinting	2.59877142
7	MP0006292_abnormal_olfactory_placode	2.41173259
8	MP0002277_abnormal_respiratory_mucosa	2.32460357
9	MP0008875_abnormal_xenobiotic_pharmacok	2.30430106
10	MP0008872_abnormal_physiological_respon	2.23544852
11	MP0002876_abnormal_thyroid_physiology	2.18499899
12	MP0005646_abnormal_pituitary_gland	2.16932132
13	MP0005377_hearing/vestibular/ear_phenot	2.04419804
14	MP0003878_abnormal_ear_physiology	2.04419804
15	MP0005379_endocrine/exocrine_gland_phen	2.03339124
16	MP0010030_abnormal_orbit_morphology	2.03127154
17	MP0004142_abnormal_muscle_tone	2.00649423
18	MP0008057_abnormal_DNA_replication	1.96669084
19	MP0003121_genomic_imprinting	1.93269229
20	MP0006072_abnormal_retinal_apoptosis	1.81107349
21	MP0003252_abnormal_bile_duct	1.78682264
22	MP0002138_abnormal_hepatobiliary_system	1.77934940
23	MP0002837_dystrophic_cardiac_calcinosis	1.77644340
24	MP0005551_abnormal_eye_electrophysiolog	1.77104839
25	MP0003646_muscle_fatigue	1.72513560
26	MP0003195_calcinosis	1.68336177
27	MP0002736_abnormal_nociception_after	1.58984175
28	MP0008058_abnormal_DNA_repair	1.58353959
29	MP0004147_increased_porphyrin_level	1.58104360
30	MP0005671_abnormal_response_to	1.48813733
31	MP0001346_abnormal_lacrimal_gland	1.46977217
32	MP0004145_abnormal_muscle_electrophysio	1.42260660
33	MP0009046_muscle_twitch	1.41330639
34	MP0005410_abnormal_fertilization	1.39686674
35	MP0002653_abnormal_ependyma_morphology	1.39011278
36	MP0005084_abnormal_gallbladder_morpholo	1.38162612
37	MP0000372_irregular_coat_pigmentation	1.35295926
38	MP0002928_abnormal_bile_duct	1.33890429
39	MP0001835_abnormal_antigen_presentation	1.33081304
40	MP0001968_abnormal_touch/_nociception	1.29528985
41	MP0002272_abnormal_nervous_system	1.20249465
42	MP0001485_abnormal_pinna_reflex	1.19472647
43	MP0000685_abnormal_immune_system	1.13851495
44	MP0005360_urolithiasis	1.11180586
45	MP0003567_abnormal_fetal_cardiomyocyte	1.11097572
46	MP0006276_abnormal_autonomic_nervous	1.10130709
47	MP0009764_decreased_sensitivity_to	1.09048564
48	MP0004019_abnormal_vitamin_homeostasis	1.08675289
49	MP0003693_abnormal_embryo_hatching	1.06362760
50	MP0004885_abnormal_endolymph	1.05049558
51	MP0002733_abnormal_thermal_nociception	1.04554278
52	MP0001873_stomach_inflammation	1.02750574
53	MP0004742_abnormal_vestibular_system	1.00259528
54	MP0001905_abnormal_dopamine_level	0.99103979
55	MP0003122_maternal_imprinting	0.97417676
56	MP0000631_abnormal_neuroendocrine_gland	0.97033936
57	MP0002938_white_spotting	0.96904204
58	MP0003866_abnormal_defecation	0.96641554
59	MP0002210_abnormal_sex_determination	0.95793725
60	MP0005195_abnormal_posterior_eye	0.94625420
61	MP0005253_abnormal_eye_physiology	0.93557175
62	MP0008775_abnormal_heart_ventricle	0.92333749
63	MP0003786_premature_aging	0.91923237
64	MP0001963_abnormal_hearing_physiology	0.91537282
65	MP0009745_abnormal_behavioral_response	0.91290638
66	MP0003880_abnormal_central_pattern	0.90707950
67	MP0006036_abnormal_mitochondrial_physio	0.89343862
68	MP0006035_abnormal_mitochondrial_morpho	0.88271282
69	MP0008995_early_reproductive_senescence	0.87568968
70	MP0000778_abnormal_nervous_system	0.86519759
71	MP0001119_abnormal_female_reproductive	0.85638926
72	MP0002148_abnormal_hypersensitivity_rea	0.84615567
73	MP0005389_reproductive_system_phenotype	0.84154611
74	MP0000049_abnormal_middle_ear	0.83673243
75	MP0003283_abnormal_digestive_organ	0.83041741
76	MP0005670_abnormal_white_adipose	0.82308611
77	MP0001929_abnormal_gametogenesis	0.82302729
78	MP0001970_abnormal_pain_threshold	0.81814332
79	MP0002160_abnormal_reproductive_system	0.81455168
80	MP0003959_abnormal_lean_body	0.81287922
81	MP0002693_abnormal_pancreas_physiology	0.80725370
82	MP0005367_renal/urinary_system_phenotyp	0.78712184
83	MP0000516_abnormal_urinary_system	0.78712184
84	MP0002735_abnormal_chemical_nociception	0.78511836
85	MP0010386_abnormal_urinary_bladder	0.78072383
86	MP0001293_anophthalmia	0.77677392
87	MP0001919_abnormal_reproductive_system	0.77332616
88	MP0005085_abnormal_gallbladder_physiolo	0.77054640
89	MP0004133_heterotaxia	0.75136465
90	MP0009333_abnormal_splenocyte_physiolog	0.74610447
91	MP0002095_abnormal_skin_pigmentation	0.73602601
92	MP0000427_abnormal_hair_cycle	0.73591662
93	MP0000653_abnormal_sex_gland	0.73470026
94	MP0000537_abnormal_urethra_morphology	0.73419783
95	MP0002752_abnormal_somatic_nervous	0.72198128
96	MP0003806_abnormal_nucleotide_metabolis	0.71269115
97	MP0008789_abnormal_olfactory_epithelium	0.70036658
98	MP0002067_abnormal_sensory_capabilities	0.68337474
99	MP0001663_abnormal_digestive_system	0.68330580
100	MP0003718_maternal_effect	0.67965264

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.92213469
2	Mitochondrial inheritance (HP:0001427)	4.57457908
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.28610754
4	Acute encephalopathy (HP:0006846)	4.26576782
5	3-Methylglutaconic aciduria (HP:0003535)	4.17784756
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.15843543
7	Reticulocytopenia (HP:0001896)	4.12801074
8	Increased CSF lactate (HP:0002490)	3.98400827
9	Progressive macrocephaly (HP:0004481)	3.98131357
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.88990978
11	Pancreatic cysts (HP:0001737)	3.79388484
12	Congenital stationary night blindness (HP:0007642)	3.55192733
13	Hepatocellular necrosis (HP:0001404)	3.53386482
14	Increased hepatocellular lipid droplets (HP:0006565)	3.51643912
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.46993494
16	Pancreatic fibrosis (HP:0100732)	3.34392455
17	Lipid accumulation in hepatocytes (HP:0006561)	3.32047496
18	True hermaphroditism (HP:0010459)	3.28261273
19	Macrocytic anemia (HP:0001972)	3.28021032
20	Hepatic necrosis (HP:0002605)	3.22707950
21	Abnormal number of erythroid precursors (HP:0012131)	3.06965310
22	Stomatitis (HP:0010280)	3.05716495
23	Congenital, generalized hypertrichosis (HP:0004540)	2.96290794
24	Colon cancer (HP:0003003)	2.83984450
25	Cerebral edema (HP:0002181)	2.80845399
26	Optic disc pallor (HP:0000543)	2.76453655
27	Decreased central vision (HP:0007663)	2.67957617
28	Abnormality of midbrain morphology (HP:0002418)	2.67212893
29	Molar tooth sign on MRI (HP:0002419)	2.67212893
30	Abnormality of the renal cortex (HP:0011035)	2.65559802
31	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.63123440
32	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.56997426
33	Type II lissencephaly (HP:0007260)	2.53929037
34	Renal Fanconi syndrome (HP:0001994)	2.49668680
35	Lactic acidosis (HP:0003128)	2.46244566
36	Cystic liver disease (HP:0006706)	2.45840051
37	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.42053638
38	Absent/shortened dynein arms (HP:0200106)	2.42053638
39	Asplenia (HP:0001746)	2.41588656
40	Sclerocornea (HP:0000647)	2.41460285
41	Abnormal respiratory epithelium morphology (HP:0012253)	2.40194287
42	Abnormal respiratory motile cilium morphology (HP:0005938)	2.40194287
43	Elevated erythrocyte sedimentation rate (HP:0003565)	2.33230252
44	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.31987164
45	Hyperglycinemia (HP:0002154)	2.30126474
46	Increased serum lactate (HP:0002151)	2.27925912
47	Respiratory failure (HP:0002878)	2.26098663
48	Supernumerary spleens (HP:0009799)	2.24190510
49	Nephronophthisis (HP:0000090)	2.18982360
50	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.17565955
51	Abnormality of the renal medulla (HP:0100957)	2.16760326
52	Exertional dyspnea (HP:0002875)	2.16028769
53	Leukodystrophy (HP:0002415)	2.15998567
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15108003
55	Abnormality of the labia minora (HP:0012880)	2.14962848
56	Abnormality of T cell physiology (HP:0011840)	2.14390821
57	Pendular nystagmus (HP:0012043)	2.14096150
58	Increased intramyocellular lipid droplets (HP:0012240)	2.13361982
59	Carpal bone hypoplasia (HP:0001498)	2.10838318
60	Abnormal ciliary motility (HP:0012262)	2.04721810
61	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04264765
62	Abnormality of alanine metabolism (HP:0010916)	2.04264765
63	Hyperalaninemia (HP:0003348)	2.04264765
64	Attenuation of retinal blood vessels (HP:0007843)	2.04198974
65	Methylmalonic acidemia (HP:0002912)	2.02397761
66	Autoimmune thrombocytopenia (HP:0001973)	2.01087400
67	Cerebellar dysplasia (HP:0007033)	2.00275990
68	Abnormal drinking behavior (HP:0030082)	1.99171306
69	Polydipsia (HP:0001959)	1.99171306
70	Male pseudohermaphroditism (HP:0000037)	1.97379289
71	Exercise intolerance (HP:0003546)	1.95659708
72	Methylmalonic aciduria (HP:0012120)	1.94893866
73	Stenosis of the external auditory canal (HP:0000402)	1.94024396
74	Testicular atrophy (HP:0000029)	1.92952509
75	Genetic anticipation (HP:0003743)	1.92135909
76	Abnormal respiratory motile cilium physiology (HP:0012261)	1.91806888
77	Septo-optic dysplasia (HP:0100842)	1.91457740
78	Bile duct proliferation (HP:0001408)	1.90673052
79	Abnormal biliary tract physiology (HP:0012439)	1.90673052
80	Dyschromatopsia (HP:0007641)	1.88700922
81	Rib fusion (HP:0000902)	1.88458705
82	IgG deficiency (HP:0004315)	1.88169544
83	Visual hallucinations (HP:0002367)	1.87532462
84	Anencephaly (HP:0002323)	1.86826122
85	Agitation (HP:0000713)	1.85093957
86	Microretrognathia (HP:0000308)	1.84734315
87	Confusion (HP:0001289)	1.84601295
88	Polyuria (HP:0000103)	1.84340108
89	Myokymia (HP:0002411)	1.83388233
90	Absent thumb (HP:0009777)	1.82931814
91	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.81251468
92	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.81251468
93	Tubulointerstitial fibrosis (HP:0005576)	1.80732349
94	Lethargy (HP:0001254)	1.80688779
95	Increased muscle lipid content (HP:0009058)	1.76812828
96	Renal cortical cysts (HP:0000803)	1.76422142
97	Abolished electroretinogram (ERG) (HP:0000550)	1.74911818
98	Congenital hepatic fibrosis (HP:0002612)	1.74777806
99	Abnormality of urine glucose concentration (HP:0011016)	1.73940018
100	Glycosuria (HP:0003076)	1.73940018

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.65252974
2	ZAK	3.19614010
3	VRK2	2.58642983
4	TLK1	2.57760839
5	NEK1	2.42291783
6	STK16	2.39252151
7	NUAK1	2.38410472
8	ADRBK2	2.26357731
9	WNK4	2.22278197
10	MAP4K2	2.16577396
11	INSRR	1.93092284
12	CAMKK2	1.91413123
13	TAF1	1.89990558
14	NME2	1.88905617
15	FRK	1.87631673
16	GRK1	1.73539169
17	CDK19	1.67895941
18	MST4	1.57532298
19	VRK1	1.55980512
20	TAOK3	1.55346705
21	PLK4	1.52595496
22	BCKDK	1.51974453
23	WNK3	1.50451509
24	TIE1	1.47964388
25	MAP3K12	1.45714919
26	BCR	1.41149883
27	DYRK2	1.40351739
28	EPHA4	1.36084205
29	MUSK	1.34249411
30	KDR	1.33970903
31	OXSR1	1.28418765
32	PHKG1	1.27958742
33	PHKG2	1.27958742
34	MAP4K1	1.24974605
35	MAP3K11	1.22797673
36	PASK	1.20375823
37	PINK1	1.20149542
38	SRPK1	1.18899584
39	BMPR1B	1.17449875
40	EPHB2	1.13817831
41	EIF2AK3	1.12536071
42	TEC	1.05414110
43	TSSK6	1.03813414
44	RPS6KA5	1.00463941
45	EIF2AK1	1.00039682
46	PIK3CG	0.98642704
47	AKT3	0.94415964
48	TRIM28	0.92640562
49	DAPK2	0.91897986
50	PLK3	0.89088949
51	ADRBK1	0.86266804
52	GRK5	0.85643499
53	IKBKB	0.84024714
54	TNK2	0.83926430
55	STK39	0.83794156
56	CSNK1A1L	0.83537340
57	CSNK1G2	0.83275657
58	CSNK1G3	0.82676260
59	MAP2K6	0.80039252
60	TNIK	0.77598328
61	LRRK2	0.74376630
62	TESK2	0.70517047
63	OBSCN	0.70150186
64	ITK	0.70128398
65	PIK3CA	0.68949514
66	PRKCQ	0.67570208
67	IKBKE	0.67169187
68	LMTK2	0.63889450
69	ATR	0.61735506
70	AURKB	0.61713005
71	CSNK1G1	0.61160862
72	CHEK2	0.60919568
73	NLK	0.60647933
74	CDC7	0.59572221
75	NME1	0.57834912
76	MKNK1	0.56704710
77	CSNK2A2	0.55034021
78	PRKCG	0.54540759
79	PLK1	0.50775226
80	MAP2K7	0.50677532
81	MAPK13	0.50553819
82	CSNK1A1	0.50304157
83	PTK2B	0.49829452
84	CSNK2A1	0.48981754
85	WNK1	0.48340027
86	IRAK1	0.47218692
87	MKNK2	0.46888539
88	PLK2	0.46337131
89	PRKACA	0.45548908
90	PIM1	0.45219498
91	TGFBR1	0.44729421
92	DAPK3	0.44712862
93	BUB1	0.44046476
94	PIM2	0.42085503
95	PRKCE	0.41671652
96	AURKA	0.41658904
97	CAMK1	0.41619366
98	CASK	0.41053870
99	PNCK	0.39734714
100	PBK	0.38766018

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.36961565
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.86333890
3	Parkinsons disease_Homo sapiens_hsa05012	3.27468932
4	Proteasome_Homo sapiens_hsa03050	3.15187960
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.01326642
6	Protein export_Homo sapiens_hsa03060	2.54779142
7	Huntingtons disease_Homo sapiens_hsa05016	2.28233921
8	RNA polymerase_Homo sapiens_hsa03020	2.23565820
9	Alzheimers disease_Homo sapiens_hsa05010	2.16984379
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.07961280
11	Homologous recombination_Homo sapiens_hsa03440	2.03326588
12	Cardiac muscle contraction_Homo sapiens_hsa04260	1.95172164
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.92937412
14	Basal transcription factors_Homo sapiens_hsa03022	1.84366584
15	RNA degradation_Homo sapiens_hsa03018	1.83314886
16	Sulfur metabolism_Homo sapiens_hsa00920	1.78255082
17	Mismatch repair_Homo sapiens_hsa03430	1.67956155
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57153831
19	Butanoate metabolism_Homo sapiens_hsa00650	1.57002961
20	Asthma_Homo sapiens_hsa05310	1.55082093
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.53695381
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.51922439
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.47859293
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.46782114
25	Caffeine metabolism_Homo sapiens_hsa00232	1.46748261
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.39014011
27	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.34226321
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.28150264
29	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.28129437
30	Phototransduction_Homo sapiens_hsa04744	1.27478054
31	Allograft rejection_Homo sapiens_hsa05330	1.25174074
32	Spliceosome_Homo sapiens_hsa03040	1.21545014
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17615373
34	One carbon pool by folate_Homo sapiens_hsa00670	1.16431246
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.14938007
36	DNA replication_Homo sapiens_hsa03030	1.08443870
37	RNA transport_Homo sapiens_hsa03013	1.07780264
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.06646072
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.05078447
40	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.01596167
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.99024316
42	Purine metabolism_Homo sapiens_hsa00230	0.92164824
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.92152033
44	Propanoate metabolism_Homo sapiens_hsa00640	0.91382496
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90446233
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.87271073
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.85911165
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.85185167
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85057442
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82910535
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82557421
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82427420
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82219545
54	Mineral absorption_Homo sapiens_hsa04978	0.79192708
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77703193
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77557789
57	Base excision repair_Homo sapiens_hsa03410	0.74701244
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.74305248
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72409536
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.71811487
61	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71259624
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.70655816
63	Selenocompound metabolism_Homo sapiens_hsa00450	0.63972838
64	Metabolic pathways_Homo sapiens_hsa01100	0.63605389
65	Graft-versus-host disease_Homo sapiens_hsa05332	0.63530288
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62140028
67	Retinol metabolism_Homo sapiens_hsa00830	0.61577550
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60159763
69	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57902501
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.57801054
71	Type I diabetes mellitus_Homo sapiens_hsa04940	0.57103153
72	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.56269699
73	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.55040121
74	Peroxisome_Homo sapiens_hsa04146	0.53940903
75	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53002196
76	Regulation of autophagy_Homo sapiens_hsa04140	0.51271625
77	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.49508236
78	Nicotine addiction_Homo sapiens_hsa05033	0.49468402
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45894600
80	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.45717467
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.45658097
82	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45294825
83	Antigen processing and presentation_Homo sapiens_hsa04612	0.42756487
84	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42217101
85	Olfactory transduction_Homo sapiens_hsa04740	0.42106167
86	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.40755621
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.39683735
88	Insulin secretion_Homo sapiens_hsa04911	0.39456594
89	Sulfur relay system_Homo sapiens_hsa04122	0.38732024
90	Glutathione metabolism_Homo sapiens_hsa00480	0.38273403
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37862975
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.35260799
93	Taste transduction_Homo sapiens_hsa04742	0.35168220
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.34829163
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.34253670
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33972138
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.33538660
98	Fatty acid degradation_Homo sapiens_hsa00071	0.24814386
99	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.24336732
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.24202313

RPL21P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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