ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of isotype switching to IgG isotypes (GO:0048302)	5.32988482
2	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	5.12961337
3	regulation of immunoglobulin secretion (GO:0051023)	5.02595572
4	ATP synthesis coupled proton transport (GO:0015986)	4.99151526
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.99151526
6	viral transcription (GO:0019083)	4.69722099
7	ribosomal large subunit biogenesis (GO:0042273)	4.55163130
8	translational termination (GO:0006415)	4.54408378
9	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.50573974
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.42869371
11	ribosomal small subunit assembly (GO:0000028)	4.35739174
12	cotranslational protein targeting to membrane (GO:0006613)	4.35043083
13	protein targeting to ER (GO:0045047)	4.32695226
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.26739049
15	protein localization to endoplasmic reticulum (GO:0070972)	4.15912439
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.12870508
17	maturation of SSU-rRNA (GO:0030490)	4.06817829
18	translational elongation (GO:0006414)	4.00459415
19	response to xenobiotic stimulus (GO:0009410)	3.99651031
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.98523718
21	NADH dehydrogenase complex assembly (GO:0010257)	3.98523718
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.98523718
23	protein neddylation (GO:0045116)	3.86525993
24	protein complex biogenesis (GO:0070271)	3.80484000
25	proteasome assembly (GO:0043248)	3.75695928
26	behavioral response to nicotine (GO:0035095)	3.75179993
27	ribosomal small subunit biogenesis (GO:0042274)	3.67260014
28	negative regulation of T cell differentiation in thymus (GO:0033085)	3.64301741
29	termination of RNA polymerase III transcription (GO:0006386)	3.57898719
30	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.57898719
31	positive regulation of respiratory burst (GO:0060267)	3.56331239
32	interferon-gamma production (GO:0032609)	3.52096835
33	translation (GO:0006412)	3.51253452
34	regulation of chronic inflammatory response (GO:0002676)	3.47979977
35	GTP biosynthetic process (GO:0006183)	3.43674468
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.43603593
37	respiratory electron transport chain (GO:0022904)	3.42549475
38	electron transport chain (GO:0022900)	3.41617876
39	cellular protein complex disassembly (GO:0043624)	3.40584020
40	regulation of regulatory T cell differentiation (GO:0045589)	3.38762644
41	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.38742290
42	viral life cycle (GO:0019058)	3.35628184
43	DNA deamination (GO:0045006)	3.32555693
44	positive regulation of isotype switching (GO:0045830)	3.31277026
45	translational initiation (GO:0006413)	3.22946611
46	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.20329741
47	positive regulation of fatty acid transport (GO:2000193)	3.14039784
48	cellular component biogenesis (GO:0044085)	3.08614442
49	water-soluble vitamin biosynthetic process (GO:0042364)	3.06659655
50	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.05836867
51	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.05340535
52	cellular response to interferon-beta (GO:0035458)	3.04919838
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.02923693
54	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.02923693
55	S-adenosylmethionine metabolic process (GO:0046500)	3.01287812
56	fucose catabolic process (GO:0019317)	3.00809997
57	L-fucose metabolic process (GO:0042354)	3.00809997
58	L-fucose catabolic process (GO:0042355)	3.00809997
59	positive regulation of DNA recombination (GO:0045911)	2.98981490
60	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.98351368
61	response to nitrosative stress (GO:0051409)	2.94280790
62	ATP biosynthetic process (GO:0006754)	2.93235083
63	ribonucleoprotein complex biogenesis (GO:0022613)	2.92832948
64	hydrogen ion transmembrane transport (GO:1902600)	2.92227661
65	rRNA modification (GO:0000154)	2.91519401
66	positive regulation of B cell mediated immunity (GO:0002714)	2.90933749
67	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.90933749
68	protein targeting to membrane (GO:0006612)	2.90385929
69	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.86788544
70	positive regulation of prostaglandin secretion (GO:0032308)	2.85630641
71	proton transport (GO:0015992)	2.83986245
72	L-ascorbic acid metabolic process (GO:0019852)	2.83622709
73	respiratory chain complex IV assembly (GO:0008535)	2.82552570
74	rRNA catabolic process (GO:0016075)	2.81490490
75	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.79562617
76	protein-cofactor linkage (GO:0018065)	2.79105972
77	hydrogen transport (GO:0006818)	2.77201873
78	UTP biosynthetic process (GO:0006228)	2.75849384
79	regulation of cellular amino acid metabolic process (GO:0006521)	2.74930519
80	negative regulation of mast cell activation (GO:0033004)	2.71563822
81	piRNA metabolic process (GO:0034587)	2.69092838
82	protein complex disassembly (GO:0043241)	2.68461308
83	mannosylation (GO:0097502)	2.68347436
84	rRNA methylation (GO:0031167)	2.67946300
85	aldehyde catabolic process (GO:0046185)	2.67582406
86	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.65371472
87	positive regulation of activated T cell proliferation (GO:0042104)	2.64649416
88	negative regulation of B cell apoptotic process (GO:0002903)	2.63562587
89	rRNA metabolic process (GO:0016072)	2.63430637
90	positive regulation of icosanoid secretion (GO:0032305)	2.63212426
91	rRNA processing (GO:0006364)	2.62480126
92	prenylation (GO:0097354)	2.61045078
93	protein prenylation (GO:0018342)	2.61045078
94	regulation of immunoglobulin production (GO:0002637)	2.60933053
95	positive regulation of immunoglobulin production (GO:0002639)	2.58144034
96	macromolecular complex disassembly (GO:0032984)	2.56607077
97	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.56418490
98	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.56418490
99	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.56418490
100	cellular ketone body metabolic process (GO:0046950)	2.55906120

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.10109314
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.11460358
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.59253482
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.33252108
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.94321489
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.71224219
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.64378094
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.62870231
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.60464833
10	VDR_22108803_ChIP-Seq_LS180_Human	2.60271452
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.59525951
12	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.53232202
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.33846155
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.33545831
15	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.14229516
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.14083390
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.10197919
18	FOXP3_21729870_ChIP-Seq_TREG_Human	1.98069327
19	TP53_22573176_ChIP-Seq_HFKS_Human	1.92163630
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.91405636
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.86780971
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.85538505
23	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.79441924
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.72265095
25	TTF2_22483619_ChIP-Seq_HELA_Human	1.70135852
26	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.69953753
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67509589
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66714799
29	EZH2_22144423_ChIP-Seq_EOC_Human	1.64925911
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.55306056
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.50840748
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.46506117
33	GATA3_26560356_Chip-Seq_TH2_Human	1.45447395
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.44573335
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44417819
36	EWS_26573619_Chip-Seq_HEK293_Human	1.43572315
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42109469
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42109469
39	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.41312995
40	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.40510010
41	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.36228518
42	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.36201078
43	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.36194716
44	NANOG_20526341_ChIP-Seq_ESCs_Human	1.32019796
45	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.31387204
46	AR_20517297_ChIP-Seq_VCAP_Human	1.25524040
47	TAF2_19829295_ChIP-Seq_ESCs_Human	1.25073074
48	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.23609388
49	ERG_20517297_ChIP-Seq_VCAP_Human	1.22668709
50	NCOR_22424771_ChIP-Seq_293T_Human	1.22162977
51	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.22016041
52	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.21735042
53	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.21262043
54	TAF15_26573619_Chip-Seq_HEK293_Human	1.20378148
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19379499
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19019530
57	XRN2_22483619_ChIP-Seq_HELA_Human	1.18753059
58	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.18594130
59	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.16653213
60	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.16463360
61	MYC_19829295_ChIP-Seq_ESCs_Human	1.15084918
62	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14923116
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14386815
64	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13945960
65	IGF1R_20145208_ChIP-Seq_DFB_Human	1.13253460
66	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.12053609
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11596566
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11334398
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11334398
70	ERA_21632823_ChIP-Seq_H3396_Human	1.10306505
71	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.09636500
72	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09061214
73	ER_23166858_ChIP-Seq_MCF-7_Human	1.08747812
74	GABP_19822575_ChIP-Seq_HepG2_Human	1.06920178
75	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.06438074
76	DCP1A_22483619_ChIP-Seq_HELA_Human	1.06361202
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06320585
78	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.05965836
79	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04421463
80	FUS_26573619_Chip-Seq_HEK293_Human	1.03847500
81	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.03233766
82	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00497514
83	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.99476665
84	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98557552
85	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.98302739
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97055735
87	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.96931326
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96693180
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96353562
90	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95776641
91	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95535788
92	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.94891824
93	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.94792434
94	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94302956
95	CBP_20019798_ChIP-Seq_JUKART_Human	0.94302956
96	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93248400
97	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.92068453
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91664431
99	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.91558015
100	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.91288031

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.40295404
2	MP0001986_abnormal_taste_sensitivity	3.06538530
3	MP0009379_abnormal_foot_pigmentation	2.66277135
4	MP0004142_abnormal_muscle_tone	2.60976290
5	MP0001873_stomach_inflammation	2.40339319
6	MP0003806_abnormal_nucleotide_metabolis	2.34851375
7	MP0001348_abnormal_lacrimal_gland	2.30922840
8	MP0003646_muscle_fatigue	2.28796139
9	MP0006292_abnormal_olfactory_placode	2.24832352
10	MP0005671_abnormal_response_to	2.22850339
11	MP0008875_abnormal_xenobiotic_pharmacok	2.21258838
12	MP0005423_abnormal_somatic_nervous	2.18112123
13	MP0000685_abnormal_immune_system	2.15771881
14	MP0008877_abnormal_DNA_methylation	2.11503793
15	MP0002138_abnormal_hepatobiliary_system	2.08958524
16	MP0003787_abnormal_imprinting	2.03245354
17	MP0008872_abnormal_physiological_respon	1.98012935
18	MP0003195_calcinosis	1.94949526
19	MP0002254_reproductive_system_inflammat	1.94921893
20	MP0000569_abnormal_digit_pigmentation	1.88668446
21	MP0006082_CNS_inflammation	1.86347041
22	MP0004147_increased_porphyrin_level	1.83638614
23	MP0005360_urolithiasis	1.78750962
24	MP0001790_abnormal_immune_system	1.72886876
25	MP0005387_immune_system_phenotype	1.72886876
26	MP0002837_dystrophic_cardiac_calcinosis	1.70983546
27	MP0006072_abnormal_retinal_apoptosis	1.68700949
28	MP0001800_abnormal_humoral_immune	1.68680860
29	MP0005645_abnormal_hypothalamus_physiol	1.64363761
30	MP0003186_abnormal_redox_activity	1.60451433
31	MP0001968_abnormal_touch/_nociception	1.51852634
32	MP0009785_altered_susceptibility_to	1.49518026
33	MP0002876_abnormal_thyroid_physiology	1.48928576
34	MP0001501_abnormal_sleep_pattern	1.45904830
35	MP0005084_abnormal_gallbladder_morpholo	1.36987190
36	MP0003878_abnormal_ear_physiology	1.36416310
37	MP0005377_hearing/vestibular/ear_phenot	1.36416310
38	MP0009764_decreased_sensitivity_to	1.35840170
39	MP0010155_abnormal_intestine_physiology	1.34718467
40	MP0003718_maternal_effect	1.34537893
41	MP0002148_abnormal_hypersensitivity_rea	1.33781636
42	MP0006276_abnormal_autonomic_nervous	1.33465516
43	MP0001853_heart_inflammation	1.30073921
44	MP0001440_abnormal_grooming_behavior	1.29871402
45	MP0002272_abnormal_nervous_system	1.29701251
46	MP0004019_abnormal_vitamin_homeostasis	1.29520204
47	MP0001485_abnormal_pinna_reflex	1.28611244
48	MP0002736_abnormal_nociception_after	1.27304628
49	MP0005551_abnormal_eye_electrophysiolog	1.25165427
50	MP0004145_abnormal_muscle_electrophysio	1.25078782
51	MP0005000_abnormal_immune_tolerance	1.20041623
52	MP0003123_paternal_imprinting	1.16908413
53	MP0003436_decreased_susceptibility_to	1.16847207
54	MP0002723_abnormal_immune_serum	1.15847912
55	MP0008058_abnormal_DNA_repair	1.14715416
56	MP0004742_abnormal_vestibular_system	1.14704082
57	MP0005085_abnormal_gallbladder_physiolo	1.12168040
58	MP0002163_abnormal_gland_morphology	1.08868638
59	MP0006036_abnormal_mitochondrial_physio	1.06277056
60	MP0000604_amyloidosis	1.02999343
61	MP0001529_abnormal_vocalization	1.02878421
62	MP0005332_abnormal_amino_acid	1.01082463
63	MP0005636_abnormal_mineral_homeostasis	1.00715179
64	MP0005025_abnormal_response_to	1.00166985
65	MP0004885_abnormal_endolymph	0.98403635
66	MP0003890_abnormal_embryonic-extraembry	0.95477199
67	MP0000427_abnormal_hair_cycle	0.93982132
68	MP0002452_abnormal_antigen_presenting	0.92415079
69	MP0003786_premature_aging	0.92033335
70	MP0001845_abnormal_inflammatory_respons	0.90180549
71	MP0001293_anophthalmia	0.89821993
72	MP0005410_abnormal_fertilization	0.88558046
73	MP0005075_abnormal_melanosome_morpholog	0.87968808
74	MP0001663_abnormal_digestive_system	0.86595897
75	MP0001819_abnormal_immune_cell	0.86043804
76	MP0002420_abnormal_adaptive_immunity	0.84968628
77	MP0002166_altered_tumor_susceptibility	0.84827094
78	MP0009745_abnormal_behavioral_response	0.84394928
79	MP0009333_abnormal_splenocyte_physiolog	0.83614086
80	MP0002102_abnormal_ear_morphology	0.81774929
81	MP0003866_abnormal_defecation	0.80668228
82	MP0003693_abnormal_embryo_hatching	0.79995909
83	MP0000230_abnormal_systemic_arterial	0.79580953
84	MP0001970_abnormal_pain_threshold	0.79045525
85	MP0001502_abnormal_circadian_rhythm	0.78770757
86	MP0001765_abnormal_ion_homeostasis	0.78528057
87	MP0005389_reproductive_system_phenotype	0.77906566
88	MP0002160_abnormal_reproductive_system	0.77663309
89	MP0009046_muscle_twitch	0.75288889
90	MP0005310_abnormal_salivary_gland	0.73836267
91	MP0002557_abnormal_social/conspecific_i	0.73665242
92	MP0008775_abnormal_heart_ventricle	0.73534673
93	MP0003763_abnormal_thymus_physiology	0.73510671
94	MP0003880_abnormal_central_pattern	0.73331565
95	MP0001905_abnormal_dopamine_level	0.73102957
96	MP0000631_abnormal_neuroendocrine_gland	0.72671883
97	MP0009643_abnormal_urine_homeostasis	0.71993012
98	MP0005367_renal/urinary_system_phenotyp	0.71606199
99	MP0000516_abnormal_urinary_system	0.71606199
100	MP0004858_abnormal_nervous_system	0.71467572

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.92286084
2	Stomatitis (HP:0010280)	4.92125564
3	Acute encephalopathy (HP:0006846)	4.40773505
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.31985526
5	Progressive macrocephaly (HP:0004481)	4.03116786
6	Mitochondrial inheritance (HP:0001427)	4.01712932
7	Molar tooth sign on MRI (HP:0002419)	4.00453747
8	Abnormality of midbrain morphology (HP:0002418)	4.00453747
9	Increased CSF lactate (HP:0002490)	3.80628921
10	3-Methylglutaconic aciduria (HP:0003535)	3.77134872
11	Reticulocytopenia (HP:0001896)	3.75461647
12	Hepatocellular necrosis (HP:0001404)	3.74393388
13	Increased hepatocellular lipid droplets (HP:0006565)	3.65172091
14	Lipid accumulation in hepatocytes (HP:0006561)	3.62650800
15	Hepatic necrosis (HP:0002605)	3.42313372
16	Pancreatic cysts (HP:0001737)	3.38096818
17	IgG deficiency (HP:0004315)	3.30866361
18	Elevated erythrocyte sedimentation rate (HP:0003565)	3.26036336
19	Cerebral edema (HP:0002181)	3.17667944
20	Abnormality of cells of the erythroid lineage (HP:0012130)	3.17198043
21	Type II lissencephaly (HP:0007260)	3.10806307
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.87144207
23	Nephronophthisis (HP:0000090)	2.85546570
24	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.76202478
25	Exertional dyspnea (HP:0002875)	2.76151026
26	Macrocytic anemia (HP:0001972)	2.76063137
27	Pancreatic fibrosis (HP:0100732)	2.69277876
28	Increased IgM level (HP:0003496)	2.66590714
29	Aplasia/hypoplasia of the uterus (HP:0008684)	2.65775952
30	Increased serum lactate (HP:0002151)	2.61209401
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.58130835
32	Abnormal number of erythroid precursors (HP:0012131)	2.58093939
33	Decreased central vision (HP:0007663)	2.56891354
34	Optic disc pallor (HP:0000543)	2.53160889
35	Pendular nystagmus (HP:0012043)	2.52992352
36	True hermaphroditism (HP:0010459)	2.47376639
37	Abnormality of urine glucose concentration (HP:0011016)	2.44979322
38	Glycosuria (HP:0003076)	2.44979322
39	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.42676239
40	Leukodystrophy (HP:0002415)	2.42212875
41	Renal Fanconi syndrome (HP:0001994)	2.40868790
42	Cleft eyelid (HP:0000625)	2.34918245
43	Increased intramyocellular lipid droplets (HP:0012240)	2.33418398
44	Methylmalonic aciduria (HP:0012120)	2.32759716
45	Cerebellar dysplasia (HP:0007033)	2.32094814
46	Congenital, generalized hypertrichosis (HP:0004540)	2.30022382
47	Lethargy (HP:0001254)	2.24198235
48	Lactic acidosis (HP:0003128)	2.23732788
49	Congenital stationary night blindness (HP:0007642)	2.23514502
50	Methylmalonic acidemia (HP:0002912)	2.19967824
51	Increased muscle lipid content (HP:0009058)	2.18861094
52	Abnormality of the renal cortex (HP:0011035)	2.18300256
53	Respiratory failure (HP:0002878)	2.17882784
54	Abnormality of the renal medulla (HP:0100957)	2.13539376
55	Hyperphosphaturia (HP:0003109)	2.11574582
56	Exercise intolerance (HP:0003546)	2.11143103
57	Hypoplasia of the uterus (HP:0000013)	2.06527673
58	Polydipsia (HP:0001959)	2.06051397
59	Abnormal drinking behavior (HP:0030082)	2.06051397
60	Abnormality of the pons (HP:0007361)	2.04683408
61	Renal cortical cysts (HP:0000803)	2.04577081
62	Septo-optic dysplasia (HP:0100842)	2.03955280
63	Cystic liver disease (HP:0006706)	1.97245307
64	Keratoconus (HP:0000563)	1.93432597
65	Increased corneal curvature (HP:0100692)	1.93432597
66	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.92537533
67	Dicarboxylic aciduria (HP:0003215)	1.92537533
68	Decreased circulating renin level (HP:0003351)	1.92400154
69	Abnormal albumin level (HP:0012116)	1.91901977
70	Hypoalbuminemia (HP:0003073)	1.91901977
71	CNS demyelination (HP:0007305)	1.89884526
72	Chronic diarrhea (HP:0002028)	1.89739104
73	Abnormality of renal resorption (HP:0011038)	1.88669668
74	Hypomagnesemia (HP:0002917)	1.87566476
75	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.85536808
76	Medial flaring of the eyebrow (HP:0010747)	1.85062052
77	Attenuation of retinal blood vessels (HP:0007843)	1.83352981
78	Confusion (HP:0001289)	1.81540786
79	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.80221750
80	Abnormality of T cell physiology (HP:0011840)	1.80053294
81	Abnormality of vitamin B metabolism (HP:0004340)	1.79593880
82	Abnormality of the labia minora (HP:0012880)	1.78501132
83	IgA deficiency (HP:0002720)	1.78054239
84	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.77492609
85	Abolished electroretinogram (ERG) (HP:0000550)	1.77008664
86	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.76885644
87	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.76885644
88	Abnormality of magnesium homeostasis (HP:0004921)	1.76066418
89	Severe muscular hypotonia (HP:0006829)	1.75725649
90	Cerebral palsy (HP:0100021)	1.74316522
91	Stenosis of the external auditory canal (HP:0000402)	1.73977772
92	Hypoplasia of the ulna (HP:0003022)	1.73131050
93	Pancytopenia (HP:0001876)	1.72512191
94	Aplastic anemia (HP:0001915)	1.71893326
95	Hypoplasia of the radius (HP:0002984)	1.70971279
96	Hypoplasia of the pons (HP:0012110)	1.69986520
97	CNS hypomyelination (HP:0003429)	1.69735226
98	Respiratory difficulties (HP:0002880)	1.69100895
99	Emotional lability (HP:0000712)	1.69093197
100	Concave nail (HP:0001598)	1.68236284

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.51260159
2	PINK1	3.16154733
3	TLK1	2.82292138
4	MAP4K1	2.78214399
5	ZAK	2.78212044
6	NUAK1	2.64437328
7	VRK2	2.58873458
8	ADRBK2	2.57861716
9	CDK19	2.47763941
10	GRK1	2.31285025
11	MST4	2.27827126
12	MAP3K12	2.09261781
13	TAOK3	2.05227034
14	FRK	1.87424255
15	NME1	1.84288590
16	MAP4K2	1.81414991
17	WNK4	1.77568173
18	DYRK2	1.76811223
19	TSSK6	1.70074104
20	OXSR1	1.69895037
21	EIF2AK1	1.64025955
22	NEK1	1.59509385
23	PBK	1.56542933
24	ITK	1.43435458
25	TEC	1.40086331
26	STK39	1.36304293
27	PAK3	1.35031407
28	IKBKB	1.29716987
29	VRK1	1.28936341
30	KIT	1.26922409
31	TRIM28	1.25059598
32	TNIK	1.18865765
33	MYLK	1.17806234
34	TIE1	1.15928983
35	PLK4	1.15073908
36	FLT3	1.14032279
37	SRPK1	1.11327951
38	EIF2AK3	1.07332477
39	LRRK2	1.05863249
40	AKT3	1.03894914
41	MAPKAPK3	1.01801560
42	EIF2AK2	0.97341430
43	CSNK1G3	0.93903695
44	INSRR	0.93538530
45	PRKCQ	0.92967121
46	PASK	0.92395557
47	DAPK1	0.91227781
48	DAPK3	0.91183092
49	CSNK1A1L	0.90951591
50	CSNK1G1	0.84008826
51	RPS6KA5	0.81142286
52	PHKG2	0.80941888
53	PHKG1	0.80941888
54	MAP2K6	0.78332094
55	TAF1	0.77923924
56	GRK7	0.75608562
57	CSF1R	0.75521646
58	PRKCG	0.75259989
59	TYK2	0.72844649
60	PIK3CA	0.71202584
61	CSNK1G2	0.70355762
62	DAPK2	0.68283105
63	PDK2	0.67424805
64	BTK	0.66282505
65	ADRBK1	0.62221436
66	WNK3	0.61608562
67	STK16	0.61085081
68	PLK3	0.58453896
69	RPS6KA6	0.58045678
70	HIPK2	0.57145303
71	NME2	0.57002801
72	BMPR2	0.56810565
73	LCK	0.56416725
74	CCNB1	0.56237600
75	CSNK2A2	0.55265436
76	FES	0.55170445
77	IKBKE	0.54562171
78	LYN	0.53640973
79	STK4	0.52300876
80	PRKCE	0.52198042
81	EPHA3	0.51601419
82	BCKDK	0.50258309
83	JAK3	0.50016577
84	GRK5	0.49604164
85	SYK	0.48462631
86	PIK3CG	0.46522036
87	CHUK	0.45574476
88	MAP3K14	0.45512763
89	ILK	0.44748904
90	CDC7	0.44446433
91	MKNK2	0.43991547
92	PRKACA	0.41368887
93	OBSCN	0.40447953
94	RPS6KC1	0.40110880
95	RPS6KL1	0.40110880
96	PRKCI	0.40080008
97	PRKCA	0.38443318
98	CSNK1E	0.38090523
99	CSNK1A1	0.37470221
100	CAMKK2	0.37361769

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.13063076
2	Allograft rejection_Homo sapiens_hsa05330	3.82095724
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.50480236
4	Ribosome_Homo sapiens_hsa03010	3.44217295
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.39663853
6	Oxidative phosphorylation_Homo sapiens_hsa00190	3.03850737
7	Proteasome_Homo sapiens_hsa03050	2.81189642
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.71842713
9	Protein export_Homo sapiens_hsa03060	2.68841912
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.67613132
11	Parkinsons disease_Homo sapiens_hsa05012	2.32857288
12	RNA polymerase_Homo sapiens_hsa03020	2.23673220
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.83189409
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82018303
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.72508108
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.61142797
17	Alzheimers disease_Homo sapiens_hsa05010	1.55522015
18	Huntingtons disease_Homo sapiens_hsa05016	1.54362188
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.53267714
20	Caffeine metabolism_Homo sapiens_hsa00232	1.49057384
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.42752574
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.40413841
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.40316018
24	Homologous recombination_Homo sapiens_hsa03440	1.33689334
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.28012454
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.22279148
27	Fat digestion and absorption_Homo sapiens_hsa04975	1.21675616
28	Viral myocarditis_Homo sapiens_hsa05416	1.13285846
29	Basal transcription factors_Homo sapiens_hsa03022	1.13040356
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.12956981
31	RNA degradation_Homo sapiens_hsa03018	1.12047699
32	Phototransduction_Homo sapiens_hsa04744	1.10985038
33	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.04508122
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03627504
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03615269
36	Regulation of autophagy_Homo sapiens_hsa04140	1.03510185
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03423718
38	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.01335522
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.00247809
40	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.98826851
41	Sulfur metabolism_Homo sapiens_hsa00920	0.95739347
42	Purine metabolism_Homo sapiens_hsa00230	0.94521719
43	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.89278132
44	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.84888081
45	Propanoate metabolism_Homo sapiens_hsa00640	0.83389392
46	One carbon pool by folate_Homo sapiens_hsa00670	0.83085009
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.82227868
48	Glutathione metabolism_Homo sapiens_hsa00480	0.81200891
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.79615798
50	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.77638728
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.75125417
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.74463699
53	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.73640140
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72662929
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.72121485
56	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71510274
57	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.71475803
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68644476
59	Peroxisome_Homo sapiens_hsa04146	0.66069903
60	RNA transport_Homo sapiens_hsa03013	0.65903972
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65605175
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.64498134
63	Mineral absorption_Homo sapiens_hsa04978	0.63062031
64	Butanoate metabolism_Homo sapiens_hsa00650	0.62336695
65	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61773115
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.61110391
67	DNA replication_Homo sapiens_hsa03030	0.60655698
68	Mismatch repair_Homo sapiens_hsa03430	0.60365357
69	Fanconi anemia pathway_Homo sapiens_hsa03460	0.55876402
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54643744
71	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.53728410
72	Metabolic pathways_Homo sapiens_hsa01100	0.52882650
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52419767
74	Retinol metabolism_Homo sapiens_hsa00830	0.52021067
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.51404988
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49585693
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49558892
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.49501778
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.48893202
80	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.47201619
81	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.43966715
82	Leishmaniasis_Homo sapiens_hsa05140	0.41974423
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41346927
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.38156826
85	Spliceosome_Homo sapiens_hsa03040	0.37082448
86	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.36096771
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.35775311
88	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.35272217
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.33190507
90	Salivary secretion_Homo sapiens_hsa04970	0.31946693
91	Nicotine addiction_Homo sapiens_hsa05033	0.30326177
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29849217
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.27117845
94	Base excision repair_Homo sapiens_hsa03410	0.27017327
95	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.25808361
96	Morphine addiction_Homo sapiens_hsa05032	0.24236351
97	Olfactory transduction_Homo sapiens_hsa04740	0.24082924
98	Fatty acid degradation_Homo sapiens_hsa00071	0.23018596
99	Arginine biosynthesis_Homo sapiens_hsa00220	0.19950814
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.19630395

RPL21P65

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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