ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.73326800
2	ATP synthesis coupled proton transport (GO:0015986)	4.73326800
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.65957753
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.04388778
5	electron transport chain (GO:0022900)	3.68231355
6	regulation of hypersensitivity (GO:0002883)	3.66987672
7	respiratory electron transport chain (GO:0022904)	3.66501533
8	platelet dense granule organization (GO:0060155)	3.64396800
9	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.60666287
10	immunoglobulin mediated immune response (GO:0016064)	3.47082394
11	DNA deamination (GO:0045006)	3.46030196
12	NADH dehydrogenase complex assembly (GO:0010257)	3.40583864
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.40583864
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.40583864
15	negative regulation of heart rate (GO:0010459)	3.36990019
16	protein complex biogenesis (GO:0070271)	3.34046996
17	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.33458728
18	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.31111998
19	cell wall macromolecule catabolic process (GO:0016998)	3.27661940
20	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.23190034
21	positive regulation of interleukin-1 beta secretion (GO:0050718)	3.19162117
22	B cell mediated immunity (GO:0019724)	3.17212476
23	mast cell activation (GO:0045576)	3.16747763
24	tryptophan metabolic process (GO:0006568)	3.15930821
25	cell wall macromolecule metabolic process (GO:0044036)	3.14080980
26	S-adenosylmethionine metabolic process (GO:0046500)	3.13380967
27	proteasome assembly (GO:0043248)	3.10024141
28	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.08692304
29	termination of RNA polymerase III transcription (GO:0006386)	3.08692304
30	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.07006824
31	regulation of interleukin-1 beta secretion (GO:0050706)	3.05357997
32	lymphocyte costimulation (GO:0031294)	3.02805561
33	T cell costimulation (GO:0031295)	3.01504073
34	positive regulation of interleukin-1 secretion (GO:0050716)	3.00138164
35	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.99770303
36	xenobiotic catabolic process (GO:0042178)	2.98738419
37	mitochondrial respiratory chain complex assembly (GO:0033108)	2.96746507
38	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.96334925
39	tryptophan catabolic process (GO:0006569)	2.93002877
40	indole-containing compound catabolic process (GO:0042436)	2.93002877
41	indolalkylamine catabolic process (GO:0046218)	2.93002877
42	negative regulation of mast cell activation (GO:0033004)	2.92072466
43	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.91959824
44	positive regulation of antigen processing and presentation (GO:0002579)	2.90099427
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.89124350
46	kynurenine metabolic process (GO:0070189)	2.89117332
47	interferon-gamma-mediated signaling pathway (GO:0060333)	2.87404320
48	water-soluble vitamin biosynthetic process (GO:0042364)	2.87028205
49	aldehyde catabolic process (GO:0046185)	2.86931557
50	hydrogen ion transmembrane transport (GO:1902600)	2.86546632
51	organelle disassembly (GO:1903008)	2.83070710
52	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.81246380
53	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.81246380
54	proton transport (GO:0015992)	2.80725857
55	mature B cell differentiation involved in immune response (GO:0002313)	2.79960114
56	protein neddylation (GO:0045116)	2.79949255
57	positive regulation of B cell mediated immunity (GO:0002714)	2.79790027
58	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.79790027
59	positive regulation of interleukin-1 beta production (GO:0032731)	2.78653103
60	hydrogen transport (GO:0006818)	2.75911116
61	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.75100246
62	regulation of cellular amino acid metabolic process (GO:0006521)	2.73587066
63	positive regulation of mast cell degranulation (GO:0043306)	2.73125975
64	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.73125975
65	regulation of antigen processing and presentation (GO:0002577)	2.71132511
66	indolalkylamine metabolic process (GO:0006586)	2.68005009
67	ATP biosynthetic process (GO:0006754)	2.67256821
68	fucose catabolic process (GO:0019317)	2.67091772
69	L-fucose metabolic process (GO:0042354)	2.67091772
70	L-fucose catabolic process (GO:0042355)	2.67091772
71	GPI anchor biosynthetic process (GO:0006506)	2.66439130
72	regulation of interleukin-1 secretion (GO:0050704)	2.65288021
73	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.64237517
74	positive regulation of mast cell activation (GO:0033005)	2.64221400
75	ribosomal large subunit biogenesis (GO:0042273)	2.62712926
76	regulation of inflammatory response to antigenic stimulus (GO:0002861)	2.62629760
77	regulation of isotype switching to IgG isotypes (GO:0048302)	2.61760016
78	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.61655685
79	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.60368846
80	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.59427038
81	T cell receptor signaling pathway (GO:0050852)	2.59336124
82	protein prenylation (GO:0018342)	2.59163582
83	prenylation (GO:0097354)	2.59163582
84	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.58692171
85	regulation of interleukin-8 secretion (GO:2000482)	2.58560783
86	positive regulation of activated T cell proliferation (GO:0042104)	2.58309017
87	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.56985931
88	one-carbon compound transport (GO:0019755)	2.56432658
89	cytidine metabolic process (GO:0046087)	2.56357230
90	cytidine catabolic process (GO:0006216)	2.56357230
91	cytidine deamination (GO:0009972)	2.56357230
92	GPI anchor metabolic process (GO:0006505)	2.56305553
93	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.56078888
94	ribosomal small subunit assembly (GO:0000028)	2.53211990
95	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.52419276
96	positive regulation of T cell migration (GO:2000406)	2.52019972
97	piRNA metabolic process (GO:0034587)	2.49764226
98	positive regulation of T-helper 1 type immune response (GO:0002827)	2.49450962
99	ribonucleoprotein complex disassembly (GO:0032988)	2.48905626
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.48729167

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.92144367
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.55072314
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.49009091
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.44191523
5	VDR_22108803_ChIP-Seq_LS180_Human	3.34318595
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.14205266
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.72190919
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.70189028
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.61679974
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.54896423
11	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.49029045
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.39781777
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.36646516
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.29689607
15	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.19193782
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.18212377
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.16826754
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.10051979
19	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.03946355
20	TAF15_26573619_Chip-Seq_HEK293_Human	2.02591321
21	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.99853572
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.94551070
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93812238
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.92218067
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.84730944
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.77601067
27	EWS_26573619_Chip-Seq_HEK293_Human	1.69381478
28	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.66663165
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.65678430
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.63330888
31	GATA3_26560356_Chip-Seq_TH2_Human	1.62990919
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.57326715
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54241977
34	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.54148040
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.50462719
36	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.48416980
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.48416980
38	FUS_26573619_Chip-Seq_HEK293_Human	1.42558737
39	AR_20517297_ChIP-Seq_VCAP_Human	1.41025671
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39732576
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.37932033
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37932033
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.36933242
44	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.35459355
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35399044
46	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.33739849
47	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.33732143
48	P300_19829295_ChIP-Seq_ESCs_Human	1.33579120
49	MYB_26560356_Chip-Seq_TH2_Human	1.33292521
50	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.33158958
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32148065
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31721226
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31721226
54	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.26783013
55	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23503843
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.21591602
57	ERG_20517297_ChIP-Seq_VCAP_Human	1.19282673
58	SPI1_23547873_ChIP-Seq_NB4_Human	1.17865616
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16783411
60	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16168996
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.15630815
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14791943
63	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.13775760
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.13549952
65	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.13548857
66	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.13017593
67	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.12541807
68	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.08754903
69	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.07652549
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07207889
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06967759
72	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05685101
73	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05531472
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04129011
75	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.04104255
76	GBX2_23144817_ChIP-Seq_PC3_Human	1.03262825
77	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.03119375
78	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.01958684
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.01269555
80	GATA3_27048872_Chip-Seq_THYMUS_Human	1.01058850
81	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00793704
82	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.00785984
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99857911
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99600970
85	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99405872
86	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.98027585
87	BCAT_22108803_ChIP-Seq_LS180_Human	0.96933361
88	NCOR_22424771_ChIP-Seq_293T_Human	0.96882815
89	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96814176
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96175565
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95087752
92	IRF1_19129219_ChIP-ChIP_H3396_Human	0.94952259
93	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.94331695
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94119948
95	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93220064
96	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92980791
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.92666602
98	GATA3_26560356_Chip-Seq_TH1_Human	0.92056552
99	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.91435880
100	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90948692

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	5.30726781
2	MP0005671_abnormal_response_to	3.62768694
3	MP0003806_abnormal_nucleotide_metabolis	3.44262524
4	MP0000569_abnormal_digit_pigmentation	2.62452383
5	MP0001986_abnormal_taste_sensitivity	2.56569118
6	MP0008875_abnormal_xenobiotic_pharmacok	2.56172203
7	MP0009785_altered_susceptibility_to	2.49432967
8	MP0002166_altered_tumor_susceptibility	2.43431563
9	MP0001800_abnormal_humoral_immune	2.31520010
10	MP0006072_abnormal_retinal_apoptosis	2.29700625
11	MP0002148_abnormal_hypersensitivity_rea	2.23385324
12	MP0001529_abnormal_vocalization	2.16504704
13	MP0005000_abnormal_immune_tolerance	2.11888298
14	MP0002006_tumorigenesis	2.06931560
15	MP0009764_decreased_sensitivity_to	1.98825034
16	MP0005646_abnormal_pituitary_gland	1.96330695
17	MP0006082_CNS_inflammation	1.95786283
18	MP0008872_abnormal_physiological_respon	1.95645197
19	MP0000685_abnormal_immune_system	1.93953059
20	MP0003724_increased_susceptibility_to	1.86374126
21	MP0002723_abnormal_immune_serum	1.83411434
22	MP0000372_irregular_coat_pigmentation	1.79233131
23	MP0002452_abnormal_antigen_presenting	1.78593215
24	MP0009379_abnormal_foot_pigmentation	1.75956174
25	MP0002837_dystrophic_cardiac_calcinosis	1.74767258
26	MP0004142_abnormal_muscle_tone	1.66791230
27	MP0001790_abnormal_immune_system	1.66446764
28	MP0005387_immune_system_phenotype	1.66446764
29	MP0004145_abnormal_muscle_electrophysio	1.66252020
30	MP0005075_abnormal_melanosome_morpholog	1.64394493
31	MP0002876_abnormal_thyroid_physiology	1.59050439
32	MP0005367_renal/urinary_system_phenotyp	1.56754570
33	MP0000516_abnormal_urinary_system	1.56754570
34	MP0009333_abnormal_splenocyte_physiolog	1.55418650
35	MP0002420_abnormal_adaptive_immunity	1.54861611
36	MP0001819_abnormal_immune_cell	1.54446055
37	MP0008877_abnormal_DNA_methylation	1.45748778
38	MP0001968_abnormal_touch/_nociception	1.44419752
39	MP0003787_abnormal_imprinting	1.41772393
40	MP0005025_abnormal_response_to	1.38267959
41	MP0010155_abnormal_intestine_physiology	1.32769193
42	MP0005551_abnormal_eye_electrophysiolog	1.32160541
43	MP0001905_abnormal_dopamine_level	1.32040158
44	MP0003436_decreased_susceptibility_to	1.31660359
45	MP0002419_abnormal_innate_immunity	1.31526821
46	MP0003646_muscle_fatigue	1.29795345
47	MP0002138_abnormal_hepatobiliary_system	1.28036933
48	MP0003011_delayed_dark_adaptation	1.23915612
49	MP0005253_abnormal_eye_physiology	1.23382122
50	MP0001873_stomach_inflammation	1.23223958
51	MP0006036_abnormal_mitochondrial_physio	1.23221714
52	MP0003186_abnormal_redox_activity	1.22048469
53	MP0003866_abnormal_defecation	1.17860396
54	MP0001845_abnormal_inflammatory_respons	1.15755313
55	MP0002736_abnormal_nociception_after	1.14211400
56	MP0003763_abnormal_thymus_physiology	1.05944744
57	MP0000716_abnormal_immune_system	1.05034947
58	MP0005645_abnormal_hypothalamus_physiol	1.04634395
59	MP0003880_abnormal_central_pattern	1.04333810
60	MP0008469_abnormal_protein_level	1.02890357
61	MP0004147_increased_porphyrin_level	1.01451133
62	MP0002090_abnormal_vision	1.00833563
63	MP0003195_calcinosis	0.98054102
64	MP0005636_abnormal_mineral_homeostasis	0.95730090
65	MP0005410_abnormal_fertilization	0.95235606
66	MP0002398_abnormal_bone_marrow	0.93855864
67	MP0003786_premature_aging	0.90317601
68	MP0001501_abnormal_sleep_pattern	0.89953788
69	MP0001764_abnormal_homeostasis	0.89341057
70	MP0002102_abnormal_ear_morphology	0.89204052
71	MP0003172_abnormal_lysosome_physiology	0.88177837
72	MP0005084_abnormal_gallbladder_morpholo	0.88158813
73	MP0000427_abnormal_hair_cycle	0.87363703
74	MP0001919_abnormal_reproductive_system	0.87094297
75	MP0001984_abnormal_olfaction	0.86207672
76	MP0002405_respiratory_system_inflammati	0.86037215
77	MP0002272_abnormal_nervous_system	0.82752532
78	MP0003075_altered_response_to	0.81939591
79	MP0001440_abnormal_grooming_behavior	0.81060743
80	MP0009697_abnormal_copulation	0.79985075
81	MP0005423_abnormal_somatic_nervous	0.79894431
82	MP0002163_abnormal_gland_morphology	0.79722001
83	MP0006276_abnormal_autonomic_nervous	0.79531067
84	MP0003045_fibrosis	0.79145264
85	MP0000689_abnormal_spleen_morphology	0.78141842
86	MP0005174_abnormal_tail_pigmentation	0.78104678
87	MP0005085_abnormal_gallbladder_physiolo	0.77193046
88	MP0005332_abnormal_amino_acid	0.76739605
89	MP0002429_abnormal_blood_cell	0.76580229
90	MP0009046_muscle_twitch	0.76322363
91	MP0009745_abnormal_behavioral_response	0.75222224
92	MP0004885_abnormal_endolymph	0.75048848
93	MP0001756_abnormal_urination	0.74233537
94	MP0000013_abnormal_adipose_tissue	0.73116858
95	MP0003137_abnormal_impulse_conducting	0.72305685
96	MP0001970_abnormal_pain_threshold	0.72042501
97	MP0001765_abnormal_ion_homeostasis	0.71369895
98	MP0003718_maternal_effect	0.70513673
99	MP0002009_preneoplasia	0.70340482
100	MP0005165_increased_susceptibility_to	0.69622810

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.91671254
2	Hepatocellular necrosis (HP:0001404)	4.43930177
3	Progressive macrocephaly (HP:0004481)	4.38690641
4	Mitochondrial inheritance (HP:0001427)	4.37804961
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.32364102
6	3-Methylglutaconic aciduria (HP:0003535)	4.16235395
7	Congenital, generalized hypertrichosis (HP:0004540)	4.11398005
8	Acute encephalopathy (HP:0006846)	4.09305242
9	Hepatic necrosis (HP:0002605)	4.05267095
10	Increased CSF lactate (HP:0002490)	3.92029988
11	Hypoproteinemia (HP:0003075)	3.43239228
12	IgG deficiency (HP:0004315)	3.34901651
13	Hypothermia (HP:0002045)	3.34039724
14	Aplastic anemia (HP:0001915)	3.30855923
15	Cerebral edema (HP:0002181)	3.01895424
16	Abnormality of the prostate (HP:0008775)	3.01606709
17	Increased hepatocellular lipid droplets (HP:0006565)	2.95077652
18	Pancreatic cysts (HP:0001737)	2.92930511
19	Elevated erythrocyte sedimentation rate (HP:0003565)	2.92272911
20	Stomatitis (HP:0010280)	2.87879786
21	Abolished electroretinogram (ERG) (HP:0000550)	2.87299603
22	Lipid accumulation in hepatocytes (HP:0006561)	2.78225931
23	Leukodystrophy (HP:0002415)	2.70586815
24	Optic disc pallor (HP:0000543)	2.67069584
25	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.66845673
26	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.66845673
27	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.65789932
28	Increased serum lactate (HP:0002151)	2.62646935
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.57822032
30	Exertional dyspnea (HP:0002875)	2.56113146
31	Type 2 muscle fiber atrophy (HP:0003554)	2.51885464
32	Methylmalonic acidemia (HP:0002912)	2.42019396
33	Chronic diarrhea (HP:0002028)	2.40846096
34	Lactic acidosis (HP:0003128)	2.39829902
35	Respiratory failure (HP:0002878)	2.37836703
36	Congenital stationary night blindness (HP:0007642)	2.37215832
37	Alveolar cell carcinoma (HP:0006519)	2.33241089
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.32387279
39	Attenuation of retinal blood vessels (HP:0007843)	2.26646145
40	Abnormality of T cell number (HP:0011839)	2.24492971
41	Abnormality of midbrain morphology (HP:0002418)	2.24379870
42	Molar tooth sign on MRI (HP:0002419)	2.24379870
43	Aplasia/hypoplasia of the uterus (HP:0008684)	2.23274127
44	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.22694957
45	Renal Fanconi syndrome (HP:0001994)	2.22120984
46	Increased intramyocellular lipid droplets (HP:0012240)	2.21561899
47	Abnormality of the renal cortex (HP:0011035)	2.21237137
48	Chronic mucocutaneous candidiasis (HP:0002728)	2.20772943
49	Recurrent cutaneous fungal infections (HP:0011370)	2.20772943
50	T lymphocytopenia (HP:0005403)	2.20487447
51	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.18624096
52	Renal cortical cysts (HP:0000803)	2.17777004
53	Generalized aminoaciduria (HP:0002909)	2.10874848
54	True hermaphroditism (HP:0010459)	2.10776262
55	Type I transferrin isoform profile (HP:0003642)	2.07495104
56	Abnormality of T cells (HP:0002843)	2.07022393
57	Hemoptysis (HP:0002105)	2.06603421
58	Abnormality of alanine metabolism (HP:0010916)	2.05661866
59	Hyperalaninemia (HP:0003348)	2.05661866
60	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.05661866
61	Severe combined immunodeficiency (HP:0004430)	2.05426023
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.03153883
63	Absent/shortened dynein arms (HP:0200106)	2.03153883
64	Panhypogammaglobulinemia (HP:0003139)	2.01845641
65	Abnormality of T cell physiology (HP:0011840)	1.95948585
66	Muscle fiber atrophy (HP:0100295)	1.95643632
67	Lethargy (HP:0001254)	1.95510576
68	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.94316832
69	Ureteral obstruction (HP:0006000)	1.93743430
70	Exercise intolerance (HP:0003546)	1.93260274
71	Increased IgM level (HP:0003496)	1.93151448
72	Constricted visual fields (HP:0001133)	1.92246648
73	Neoplasm of the tracheobronchial system (HP:0100552)	1.91564994
74	Thyroiditis (HP:0100646)	1.91538341
75	Nephronophthisis (HP:0000090)	1.89617828
76	Type II lissencephaly (HP:0007260)	1.89312752
77	Delayed CNS myelination (HP:0002188)	1.87009030
78	Myositis (HP:0100614)	1.86518573
79	Pancreatic fibrosis (HP:0100732)	1.85075512
80	Increased muscle lipid content (HP:0009058)	1.83670481
81	Woolly hair (HP:0002224)	1.80993306
82	Pulmonary infiltrates (HP:0002113)	1.80279632
83	Retrobulbar optic neuritis (HP:0100654)	1.80209164
84	Optic neuritis (HP:0100653)	1.80209164
85	Amyotrophic lateral sclerosis (HP:0007354)	1.79102211
86	Spastic paraparesis (HP:0002313)	1.78935828
87	CNS demyelination (HP:0007305)	1.78513899
88	Cleft eyelid (HP:0000625)	1.76898563
89	Abnormality of B cell number (HP:0010975)	1.73519439
90	Gangrene (HP:0100758)	1.73137911
91	Medial flaring of the eyebrow (HP:0010747)	1.72728254
92	Recurrent fungal infections (HP:0002841)	1.70932338
93	Abnormal albumin level (HP:0012116)	1.69573002
94	Hypoalbuminemia (HP:0003073)	1.69573002
95	Abnormality of urine glucose concentration (HP:0011016)	1.68737205
96	Glycosuria (HP:0003076)	1.68737205
97	Abnormality of the renal medulla (HP:0100957)	1.68624880
98	Pancytopenia (HP:0001876)	1.67243381
99	Ureteral stenosis (HP:0000071)	1.66551669
100	Hypoplasia of the uterus (HP:0000013)	1.66200839

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR2	4.34536067
2	TXK	3.40030527
3	TAOK3	3.35876304
4	MAP4K2	3.35711713
5	TLK1	2.86697850
6	CDK19	2.74847810
7	NUAK1	2.71347261
8	MAP3K12	2.56681704
9	FRK	2.45083878
10	EIF2AK3	2.18521790
11	MAP4K1	2.06892924
12	SCYL2	2.04541992
13	ADRBK2	1.98809499
14	ZAK	1.98085460
15	KIT	1.95267033
16	MST4	1.79167202
17	FLT3	1.71812543
18	CSF1R	1.71569205
19	MYLK	1.67646305
20	OXSR1	1.60138818
21	ERBB3	1.58591864
22	BCKDK	1.57148429
23	GRK1	1.51465602
24	SRPK1	1.49771664
25	STK16	1.40009317
26	IKBKB	1.37522305
27	FES	1.34164468
28	TIE1	1.33402606
29	ITK	1.29916760
30	TEC	1.28324121
31	PINK1	1.23756159
32	KDR	1.21915847
33	WNK3	1.16847044
34	EPHA3	1.14936927
35	MAP3K14	1.12766152
36	LYN	1.12260468
37	DAPK1	1.11944833
38	INSRR	1.10783458
39	CSNK1G3	1.08660502
40	BCR	1.06612037
41	SYK	1.04381051
42	VRK2	1.03424791
43	BTK	1.01280179
44	DYRK2	0.97507580
45	TNK2	0.97493316
46	CSNK1G2	0.91685908
47	PHKG1	0.88181184
48	PHKG2	0.88181184
49	MUSK	0.86853347
50	CSNK1A1L	0.86719589
51	WNK4	0.82085556
52	MAPKAPK3	0.76477050
53	RPS6KA5	0.75726798
54	CSNK1G1	0.75352992
55	JAK3	0.74834284
56	MKNK1	0.73879172
57	LCK	0.73648607
58	OBSCN	0.72741924
59	EIF2AK2	0.71057025
60	ILK	0.70017237
61	TRPM7	0.69453347
62	MAPK13	0.69438284
63	GRK6	0.65530063
64	GRK7	0.65470230
65	PRKCE	0.61214503
66	VRK1	0.59711786
67	ABL1	0.58386747
68	IGF1R	0.56714349
69	CDK8	0.55954095
70	DAPK3	0.55812124
71	BMPR1B	0.51459217
72	ADRBK1	0.49288179
73	RIPK4	0.47342820
74	DAPK2	0.46296294
75	CHUK	0.46127217
76	IKBKE	0.45422132
77	HCK	0.43155610
78	MAPKAPK5	0.42816193
79	CSNK1A1	0.42096399
80	EGFR	0.41887347
81	ZAP70	0.41340875
82	EIF2AK1	0.38014100
83	PIK3CA	0.37567161
84	MAP2K6	0.37530548
85	PRKCQ	0.37409008
86	RPS6KA4	0.36405289
87	TRIM28	0.35311417
88	BLK	0.35155308
89	PRKACA	0.33808046
90	MAP3K4	0.33607952
91	PRKG1	0.32730619
92	PRKCA	0.32407439
93	PIK3CG	0.32121269
94	NME1	0.30470290
95	CSNK2A2	0.29797990
96	MATK	0.29262431
97	CSNK2A1	0.28905746
98	PTK2B	0.28784653
99	CAMK2A	0.28750515
100	HIPK2	0.27921317

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.51715728
2	Allograft rejection_Homo sapiens_hsa05330	4.53511669
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.22427022
4	Graft-versus-host disease_Homo sapiens_hsa05332	4.10036334
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.74376681
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.68808474
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.86824827
8	Proteasome_Homo sapiens_hsa03050	2.84014258
9	Protein export_Homo sapiens_hsa03060	2.58280129
10	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.54175009
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.52138618
12	Parkinsons disease_Homo sapiens_hsa05012	2.22214408
13	Rheumatoid arthritis_Homo sapiens_hsa05323	2.14316007
14	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.01002678
15	Viral myocarditis_Homo sapiens_hsa05416	1.94864062
16	Ribosome_Homo sapiens_hsa03010	1.89971820
17	RNA polymerase_Homo sapiens_hsa03020	1.55804613
18	Leishmaniasis_Homo sapiens_hsa05140	1.48396675
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.47082439
20	Alzheimers disease_Homo sapiens_hsa05010	1.45865298
21	Huntingtons disease_Homo sapiens_hsa05016	1.33474837
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.26218325
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.24764362
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.22013068
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.19535038
26	Regulation of autophagy_Homo sapiens_hsa04140	1.17124734
27	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.11725649
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.10731462
29	Phototransduction_Homo sapiens_hsa04744	1.10675492
30	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.10188554
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.07280349
32	RNA degradation_Homo sapiens_hsa03018	0.96814944
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.94111059
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.91973184
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.89672617
36	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.87547690
37	One carbon pool by folate_Homo sapiens_hsa00670	0.87117749
38	Homologous recombination_Homo sapiens_hsa03440	0.87046856
39	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79832970
40	Caffeine metabolism_Homo sapiens_hsa00232	0.68171961
41	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.64750461
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.64028324
43	Toxoplasmosis_Homo sapiens_hsa05145	0.63841846
44	Propanoate metabolism_Homo sapiens_hsa00640	0.63107723
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.62535873
46	Spliceosome_Homo sapiens_hsa03040	0.61961044
47	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.60015051
48	Basal transcription factors_Homo sapiens_hsa03022	0.58614541
49	Tuberculosis_Homo sapiens_hsa05152	0.57944599
50	Herpes simplex infection_Homo sapiens_hsa05168	0.57158141
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56274706
52	Phagosome_Homo sapiens_hsa04145	0.55282580
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.55046485
54	Purine metabolism_Homo sapiens_hsa00230	0.53346378
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.53294196
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.53173139
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52658168
58	Olfactory transduction_Homo sapiens_hsa04740	0.51870349
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.50383939
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.49792838
61	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46512557
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46062679
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.43446467
64	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.42740105
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.42349967
66	Influenza A_Homo sapiens_hsa05164	0.42024955
67	Butanoate metabolism_Homo sapiens_hsa00650	0.41966854
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.41376743
69	Sulfur metabolism_Homo sapiens_hsa00920	0.40213912
70	RNA transport_Homo sapiens_hsa03013	0.39174769
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.38056221
72	Peroxisome_Homo sapiens_hsa04146	0.36730547
73	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36546925
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.34574767
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34130605
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.33617609
77	Legionellosis_Homo sapiens_hsa05134	0.32933159
78	Retinol metabolism_Homo sapiens_hsa00830	0.30164520
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.29542487
80	African trypanosomiasis_Homo sapiens_hsa05143	0.29413347
81	Fatty acid elongation_Homo sapiens_hsa00062	0.27544685
82	Metabolic pathways_Homo sapiens_hsa01100	0.26943734
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.26819235
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.26334365
85	Salivary secretion_Homo sapiens_hsa04970	0.25728392
86	Taste transduction_Homo sapiens_hsa04742	0.24541891
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.23481012
88	Glutathione metabolism_Homo sapiens_hsa00480	0.23419376
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.23278172
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.23106379
91	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.22039026
92	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.21523778
93	Morphine addiction_Homo sapiens_hsa05032	0.21316675
94	GABAergic synapse_Homo sapiens_hsa04727	0.21256022
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.20585228
96	Pertussis_Homo sapiens_hsa05133	0.20064320
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.19728665
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.18973770
99	beta-Alanine metabolism_Homo sapiens_hsa00410	0.18457522
100	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.14601460

RPL21P66

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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