ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.73274538
2	ATP synthesis coupled proton transport (GO:0015986)	5.66776552
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.66776552
4	DNA deamination (GO:0045006)	5.59969254
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.30699012
6	cytidine metabolic process (GO:0046087)	4.99726432
7	cytidine catabolic process (GO:0006216)	4.99726432
8	cytidine deamination (GO:0009972)	4.99726432
9	viral transcription (GO:0019083)	4.86105978
10	translational termination (GO:0006415)	4.66231442
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.54074755
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.41083144
13	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.38535529
14	cotranslational protein targeting to membrane (GO:0006613)	4.33776166
15	protein targeting to ER (GO:0045047)	4.31674500
16	maturation of SSU-rRNA (GO:0030490)	4.28164705
17	protein complex biogenesis (GO:0070271)	4.26919498
18	chaperone-mediated protein transport (GO:0072321)	4.20039647
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.17816051
20	respiratory electron transport chain (GO:0022904)	4.12769997
21	protein localization to endoplasmic reticulum (GO:0070972)	4.11689281
22	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.11417633
23	electron transport chain (GO:0022900)	4.10690806
24	ribosomal small subunit biogenesis (GO:0042274)	4.10120447
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.07090206
26	NADH dehydrogenase complex assembly (GO:0010257)	4.07090206
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.07090206
28	translational elongation (GO:0006414)	4.05475149
29	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.95695332
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.89569879
31	behavioral response to nicotine (GO:0035095)	3.82845570
32	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.48117450
33	rRNA catabolic process (GO:0016075)	3.45677517
34	cellular protein complex disassembly (GO:0043624)	3.42278838
35	regulation of regulatory T cell differentiation (GO:0045589)	3.37092909
36	viral life cycle (GO:0019058)	3.36347192
37	positive regulation of respiratory burst (GO:0060267)	3.36291579
38	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.30037051
39	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.30037051
40	translation (GO:0006412)	3.28170402
41	water-soluble vitamin biosynthetic process (GO:0042364)	3.27096190
42	hydrogen ion transmembrane transport (GO:1902600)	3.26893719
43	protein neddylation (GO:0045116)	3.25390677
44	cellular response to interleukin-15 (GO:0071350)	3.21469213
45	translational initiation (GO:0006413)	3.20624657
46	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.18904475
47	ATP biosynthetic process (GO:0006754)	3.15785823
48	ribosomal large subunit biogenesis (GO:0042273)	3.15430056
49	proton transport (GO:0015992)	3.13086778
50	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.11543754
51	proteasome assembly (GO:0043248)	3.11519903
52	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.10131798
53	regulation of isotype switching to IgG isotypes (GO:0048302)	3.09909155
54	hydrogen transport (GO:0006818)	3.08140125
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.05842529
56	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.05229259
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.04831500
58	regulation of cellular respiration (GO:0043457)	2.97027005
59	negative regulation of T cell differentiation in thymus (GO:0033085)	2.95533191
60	kynurenine metabolic process (GO:0070189)	2.95528465
61	positive regulation of defense response to virus by host (GO:0002230)	2.94581980
62	GTP biosynthetic process (GO:0006183)	2.92227384
63	endoderm formation (GO:0001706)	2.90592167
64	indole-containing compound catabolic process (GO:0042436)	2.88954633
65	indolalkylamine catabolic process (GO:0046218)	2.88954633
66	tryptophan catabolic process (GO:0006569)	2.88954633
67	respiratory chain complex IV assembly (GO:0008535)	2.79029228
68	protein targeting to membrane (GO:0006612)	2.75749487
69	positive regulation of T-helper 1 type immune response (GO:0002827)	2.73477052
70	cytochrome complex assembly (GO:0017004)	2.73147695
71	cellular response to interferon-beta (GO:0035458)	2.72855624
72	platelet dense granule organization (GO:0060155)	2.72615180
73	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.72410252
74	protein complex disassembly (GO:0043241)	2.70424361
75	L-fucose catabolic process (GO:0042355)	2.65460392
76	fucose catabolic process (GO:0019317)	2.65460392
77	L-fucose metabolic process (GO:0042354)	2.65460392
78	somite development (GO:0061053)	2.64500725
79	interferon-gamma production (GO:0032609)	2.63716470
80	macromolecular complex disassembly (GO:0032984)	2.63170157
81	cellular component biogenesis (GO:0044085)	2.62937293
82	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.60804410
83	response to xenobiotic stimulus (GO:0009410)	2.58796882
84	positive regulation of fatty acid transport (GO:2000193)	2.56052707
85	nonmotile primary cilium assembly (GO:0035058)	2.55964673
86	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.53749706
87	intracellular protein transmembrane import (GO:0044743)	2.51096303
88	positive regulation of T cell migration (GO:2000406)	2.48877225
89	indolalkylamine metabolic process (GO:0006586)	2.48694122
90	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.48313621
91	negative regulation of telomere maintenance (GO:0032205)	2.47004039
92	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.45650939
93	tryptophan metabolic process (GO:0006568)	2.44394455
94	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.43951621
95	organelle disassembly (GO:1903008)	2.41726352
96	adaptation of signaling pathway (GO:0023058)	2.40585417
97	detection of light stimulus involved in visual perception (GO:0050908)	2.39197364
98	detection of light stimulus involved in sensory perception (GO:0050962)	2.39197364
99	rRNA metabolic process (GO:0016072)	2.38519909
100	response to interferon-beta (GO:0035456)	2.36572160

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.52211701
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.04163089
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.82814077
4	VDR_22108803_ChIP-Seq_LS180_Human	3.21810827
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.18633978
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.08929177
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.79401233
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.55611844
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.53495260
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.42972537
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.32182100
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.28276533
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.23952552
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.23039324
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18731506
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.15798443
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11339021
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.96890931
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.85093404
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.83069426
21	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.80958658
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.70938706
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.67950240
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66357611
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.64952366
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.64876772
27	EWS_26573619_Chip-Seq_HEK293_Human	1.63991563
28	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.61489335
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60179769
30	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.59733952
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.59245517
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.53511743
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.53511743
34	IGF1R_20145208_ChIP-Seq_DFB_Human	1.49439373
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.43643508
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43119373
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.40403046
38	GATA3_26560356_Chip-Seq_TH2_Human	1.39572337
39	AR_20517297_ChIP-Seq_VCAP_Human	1.39134925
40	TAF2_19829295_ChIP-Seq_ESCs_Human	1.36323527
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35645995
42	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.34556202
43	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.34457425
44	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.34239968
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33967754
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.33461246
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30075462
48	NANOG_20526341_ChIP-Seq_ESCs_Human	1.29972177
49	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.29294235
50	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.28833898
51	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.27998599
52	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.27756379
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.27723439
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26874226
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24001907
56	TTF2_22483619_ChIP-Seq_HELA_Human	1.20110243
57	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.18770408
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.17357898
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.17095502
60	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16783828
61	TAF15_26573619_Chip-Seq_HEK293_Human	1.16609459
62	P300_19829295_ChIP-Seq_ESCs_Human	1.16407037
63	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.15145447
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14130323
65	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14091016
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.13737239
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12817101
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12817101
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12109033
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.11662933
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10986284
72	GBX2_23144817_ChIP-Seq_PC3_Human	1.10145025
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09389221
74	NCOR_22424771_ChIP-Seq_293T_Human	1.08500924
75	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.07199019
76	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.06851172
77	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06374270
78	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.05040357
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.03358432
80	CBP_20019798_ChIP-Seq_JUKART_Human	1.03358432
81	RUNX_20019798_ChIP-Seq_JUKART_Human	1.03022229
82	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02591742
83	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02085270
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01452015
85	ERA_21632823_ChIP-Seq_H3396_Human	1.01344443
86	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.01029092
87	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.00751981
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00567156
89	STAT1_20625510_ChIP-Seq_HELA_Human	0.98663595
90	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.98214481
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98041956
92	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.97310857
93	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.96071916
94	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.95745336
95	TCF4_22108803_ChIP-Seq_LS180_Human	0.93584899
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92758326
97	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.89214530
98	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.88781675
99	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.88484685
100	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.88476631

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.40919421
2	MP0005671_abnormal_response_to	3.37092583
3	MP0002163_abnormal_gland_morphology	3.33892874
4	MP0001835_abnormal_antigen_presentation	3.13105831
5	MP0003806_abnormal_nucleotide_metabolis	2.76949920
6	MP0001986_abnormal_taste_sensitivity	2.51173279
7	MP0001348_abnormal_lacrimal_gland	2.43821218
8	MP0008872_abnormal_physiological_respon	2.37798108
9	MP0008875_abnormal_xenobiotic_pharmacok	2.29560307
10	MP0002102_abnormal_ear_morphology	2.24609818
11	MP0006292_abnormal_olfactory_placode	2.23452627
12	MP0004142_abnormal_muscle_tone	2.16836916
13	MP0006072_abnormal_retinal_apoptosis	2.14938416
14	MP0002876_abnormal_thyroid_physiology	2.08630488
15	MP0005379_endocrine/exocrine_gland_phen	2.03757276
16	MP0001800_abnormal_humoral_immune	1.89275400
17	MP0001968_abnormal_touch/_nociception	1.86503530
18	MP0004145_abnormal_muscle_electrophysio	1.82785899
19	MP0002148_abnormal_hypersensitivity_rea	1.77327837
20	MP0002138_abnormal_hepatobiliary_system	1.75074772
21	MP0004147_increased_porphyrin_level	1.68716879
22	MP0008877_abnormal_DNA_methylation	1.67678847
23	MP0004742_abnormal_vestibular_system	1.67233723
24	MP0000685_abnormal_immune_system	1.67013537
25	MP0005387_immune_system_phenotype	1.65483060
26	MP0001790_abnormal_immune_system	1.65483060
27	MP0001873_stomach_inflammation	1.60863772
28	MP0005551_abnormal_eye_electrophysiolog	1.58652623
29	MP0003878_abnormal_ear_physiology	1.52924705
30	MP0005377_hearing/vestibular/ear_phenot	1.52924705
31	MP0009785_altered_susceptibility_to	1.45174544
32	MP0005000_abnormal_immune_tolerance	1.45065976
33	MP0002723_abnormal_immune_serum	1.42403055
34	MP0003866_abnormal_defecation	1.39688549
35	MP0004885_abnormal_endolymph	1.37972225
36	MP0002837_dystrophic_cardiac_calcinosis	1.35896982
37	MP0006082_CNS_inflammation	1.33449708
38	MP0000372_irregular_coat_pigmentation	1.33008888
39	MP0010155_abnormal_intestine_physiology	1.32932868
40	MP0001919_abnormal_reproductive_system	1.29780402
41	MP0005085_abnormal_gallbladder_physiolo	1.28260514
42	MP0002272_abnormal_nervous_system	1.27429820
43	MP0003011_delayed_dark_adaptation	1.27177306
44	MP0002452_abnormal_antigen_presenting	1.25224397
45	MP0005360_urolithiasis	1.25054962
46	MP0005389_reproductive_system_phenotype	1.22911038
47	MP0001905_abnormal_dopamine_level	1.22260659
48	MP0008789_abnormal_olfactory_epithelium	1.22157871
49	MP0002736_abnormal_nociception_after	1.21537753
50	MP0005084_abnormal_gallbladder_morpholo	1.20338723
51	MP0003195_calcinosis	1.17942836
52	MP0005645_abnormal_hypothalamus_physiol	1.17682977
53	MP0009745_abnormal_behavioral_response	1.16478283
54	MP0001853_heart_inflammation	1.16421203
55	MP0001819_abnormal_immune_cell	1.14322642
56	MP0002420_abnormal_adaptive_immunity	1.14254410
57	MP0009333_abnormal_splenocyte_physiolog	1.13550821
58	MP0002638_abnormal_pupillary_reflex	1.12889878
59	MP0001529_abnormal_vocalization	1.12827880
60	MP0001485_abnormal_pinna_reflex	1.09956311
61	MP0005025_abnormal_response_to	1.09445328
62	MP0002277_abnormal_respiratory_mucosa	1.08982568
63	MP0009764_decreased_sensitivity_to	1.08830171
64	MP0006036_abnormal_mitochondrial_physio	1.07057154
65	MP0003786_premature_aging	1.06501702
66	MP0001845_abnormal_inflammatory_respons	1.05169883
67	MP0002234_abnormal_pharynx_morphology	1.03796959
68	MP0003763_abnormal_thymus_physiology	1.01706013
69	MP0005408_hypopigmentation	1.01693060
70	MP0003186_abnormal_redox_activity	1.01640769
71	MP0003646_muscle_fatigue	1.01369845
72	MP0001293_anophthalmia	1.01233696
73	MP0005075_abnormal_melanosome_morpholog	1.00235803
74	MP0005253_abnormal_eye_physiology	0.97276385
75	MP0000569_abnormal_digit_pigmentation	0.97189809
76	MP0005367_renal/urinary_system_phenotyp	0.96469148
77	MP0000516_abnormal_urinary_system	0.96469148
78	MP0001440_abnormal_grooming_behavior	0.95307212
79	MP0004019_abnormal_vitamin_homeostasis	0.94916940
80	MP0001970_abnormal_pain_threshold	0.94086478
81	MP0001486_abnormal_startle_reflex	0.94061136
82	MP0003718_maternal_effect	0.93859872
83	MP0002006_tumorigenesis	0.91262802
84	MP0001984_abnormal_olfaction	0.84698821
85	MP0005332_abnormal_amino_acid	0.84510986
86	MP0002166_altered_tumor_susceptibility	0.83073302
87	MP0002160_abnormal_reproductive_system	0.80799660
88	MP0005174_abnormal_tail_pigmentation	0.80485986
89	MP0005636_abnormal_mineral_homeostasis	0.80238211
90	MP0005310_abnormal_salivary_gland	0.79215115
91	MP0000716_abnormal_immune_system	0.78688634
92	MP0000427_abnormal_hair_cycle	0.78100884
93	MP0005365_abnormal_bile_salt	0.77226966
94	MP0001501_abnormal_sleep_pattern	0.75871256
95	MP0005423_abnormal_somatic_nervous	0.74037073
96	MP0002733_abnormal_thermal_nociception	0.73871378
97	MP0003567_abnormal_fetal_cardiomyocyte	0.73268185
98	MP0002653_abnormal_ependyma_morphology	0.72699479
99	MP0001542_abnormal_bone_strength	0.72428337
100	MP0000465_gastrointestinal_hemorrhage	0.72416347

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.68507322
2	3-Methylglutaconic aciduria (HP:0003535)	4.31923722
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.19136184
4	Mitochondrial inheritance (HP:0001427)	4.12638229
5	Congenital, generalized hypertrichosis (HP:0004540)	4.05796460
6	IgG deficiency (HP:0004315)	4.03453050
7	Increased IgM level (HP:0003496)	4.02182472
8	Acute encephalopathy (HP:0006846)	4.01229921
9	Progressive macrocephaly (HP:0004481)	3.86059006
10	Hepatocellular necrosis (HP:0001404)	3.71564233
11	Increased CSF lactate (HP:0002490)	3.68515817
12	Reticulocytopenia (HP:0001896)	3.53674719
13	Congenital stationary night blindness (HP:0007642)	3.30197742
14	Pancreatic cysts (HP:0001737)	3.19494639
15	Hepatic necrosis (HP:0002605)	3.17880656
16	Abnormality of cells of the erythroid lineage (HP:0012130)	3.09148960
17	Abnormality of midbrain morphology (HP:0002418)	3.03918896
18	Molar tooth sign on MRI (HP:0002419)	3.03918896
19	Lipid accumulation in hepatocytes (HP:0006561)	3.00658251
20	Increased hepatocellular lipid droplets (HP:0006565)	2.97620857
21	Stomatitis (HP:0010280)	2.88231564
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.87647895
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.87647895
24	Colon cancer (HP:0003003)	2.79077125
25	Cerebral edema (HP:0002181)	2.77816094
26	Optic disc pallor (HP:0000543)	2.75675063
27	Abnormal biliary tract physiology (HP:0012439)	2.75572104
28	Bile duct proliferation (HP:0001408)	2.75572104
29	Abnormality of T cell number (HP:0011839)	2.70629283
30	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.67012521
31	Macrocytic anemia (HP:0001972)	2.66192379
32	Abnormality of the prostate (HP:0008775)	2.65634410
33	Abnormal number of erythroid precursors (HP:0012131)	2.58936153
34	Elevated erythrocyte sedimentation rate (HP:0003565)	2.56773906
35	Abnormality of eosinophils (HP:0001879)	2.53051141
36	Pancreatic fibrosis (HP:0100732)	2.51040467
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.46412925
38	Increased intramyocellular lipid droplets (HP:0012240)	2.44990566
39	Methylmalonic acidemia (HP:0002912)	2.43406521
40	Abnormality of B cell number (HP:0010975)	2.40384071
41	Eosinophilia (HP:0001880)	2.39442384
42	True hermaphroditism (HP:0010459)	2.36754933
43	Leukodystrophy (HP:0002415)	2.34874851
44	Lactic acidosis (HP:0003128)	2.33925628
45	Increased serum lactate (HP:0002151)	2.33530932
46	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.29729238
47	Abnormality of T cells (HP:0002843)	2.28513328
48	Autoimmune thrombocytopenia (HP:0001973)	2.27165019
49	Abnormality of the renal cortex (HP:0011035)	2.26266522
50	Methylmalonic aciduria (HP:0012120)	2.22657163
51	Respiratory failure (HP:0002878)	2.20859104
52	Abnormality of T cell physiology (HP:0011840)	2.20797216
53	Type 2 muscle fiber atrophy (HP:0003554)	2.19917506
54	Increased muscle lipid content (HP:0009058)	2.18062436
55	Renal Fanconi syndrome (HP:0001994)	2.15179087
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.13758477
57	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.13566376
58	Severe combined immunodeficiency (HP:0004430)	2.12408549
59	Stomach cancer (HP:0012126)	2.11543351
60	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.09833402
61	Conical tooth (HP:0000698)	2.09276323
62	Aplasia/hypoplasia of the uterus (HP:0008684)	2.07986249
63	Hyperglycinemia (HP:0002154)	2.05784734
64	Pendular nystagmus (HP:0012043)	2.04499959
65	Exertional dyspnea (HP:0002875)	2.03402556
66	Absent thumb (HP:0009777)	2.00802652
67	Lethargy (HP:0001254)	2.00230990
68	Abolished electroretinogram (ERG) (HP:0000550)	1.98491965
69	Abnormality of DNA repair (HP:0003254)	1.98276741
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.98072996
71	Thyroiditis (HP:0100646)	1.97895324
72	Sclerocornea (HP:0000647)	1.94823131
73	Nephronophthisis (HP:0000090)	1.94450473
74	T lymphocytopenia (HP:0005403)	1.94205934
75	Delayed CNS myelination (HP:0002188)	1.94074244
76	Increased corneal curvature (HP:0100692)	1.93513379
77	Keratoconus (HP:0000563)	1.93513379
78	Hypoproteinemia (HP:0003075)	1.92024333
79	Concave nail (HP:0001598)	1.89453002
80	Asplenia (HP:0001746)	1.88681553
81	Renal cortical cysts (HP:0000803)	1.88642755
82	IgA deficiency (HP:0002720)	1.88514402
83	Muscle fiber atrophy (HP:0100295)	1.88434557
84	Rib fusion (HP:0000902)	1.85037109
85	Hypoplasia of the radius (HP:0002984)	1.84833683
86	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84087236
87	Abnormality of alanine metabolism (HP:0010916)	1.84087236
88	Hyperalaninemia (HP:0003348)	1.84087236
89	Pallor (HP:0000980)	1.82219405
90	Chronic mucocutaneous candidiasis (HP:0002728)	1.81902000
91	Recurrent cutaneous fungal infections (HP:0011370)	1.81902000
92	Exercise intolerance (HP:0003546)	1.79605789
93	Chronic diarrhea (HP:0002028)	1.79455262
94	Granulocytopenia (HP:0001913)	1.79419938
95	Abnormality of the renal medulla (HP:0100957)	1.77718382
96	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.76486778
97	Prostate neoplasm (HP:0100787)	1.75748398
98	Neutropenia (HP:0001875)	1.75630231
99	Hemoptysis (HP:0002105)	1.72782028
100	Cleft eyelid (HP:0000625)	1.72242702

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	6.49913180
2	VRK2	3.02187236
3	ADRBK2	2.92035148
4	NUAK1	2.86727506
5	ZAK	2.36887145
6	WNK4	2.28643743
7	TLK1	2.25759868
8	MAP3K12	2.10433774
9	TAOK3	2.09992949
10	PINK1	2.06011681
11	GRK1	2.05969913
12	CDK19	1.79081749
13	FRK	1.71381553
14	MAP4K1	1.67705689
15	MST4	1.64569772
16	OXSR1	1.59457844
17	DYRK2	1.55286075
18	MAP4K2	1.51381785
19	ITK	1.50961883
20	BMPR1B	1.48684478
21	BMPR2	1.47471389
22	STK16	1.42701081
23	VRK1	1.42153951
24	GRK6	1.35205253
25	IKBKB	1.31994258
26	STK39	1.30201691
27	PIK3CA	1.29051107
28	INSRR	1.27013733
29	MUSK	1.25411074
30	SRPK1	1.25102706
31	TSSK6	1.24331749
32	BCR	1.22451742
33	TIE1	1.19543939
34	ACVR1B	1.18677598
35	MAP2K2	1.17951399
36	WNK3	1.14985573
37	NME1	1.10200952
38	PASK	1.03658791
39	MYLK	1.03613182
40	CAMKK2	1.02763847
41	TAF1	1.02716964
42	KDR	1.01796697
43	TEC	0.99499137
44	BCKDK	0.95639636
45	MAPKAPK5	0.91420851
46	SYK	0.88382488
47	TRIM28	0.87400392
48	GRK7	0.85607260
49	LYN	0.82699431
50	NME2	0.80149502
51	DAPK3	0.79576046
52	PLK4	0.73846641
53	KIT	0.72614714
54	BTK	0.71845402
55	FES	0.71742807
56	PDK2	0.71699995
57	PLK2	0.68524831
58	CSK	0.67456477
59	EIF2AK3	0.67226777
60	PRKCE	0.66995082
61	PRKCQ	0.64966613
62	MAPK13	0.63714928
63	RPS6KA5	0.61411883
64	IKBKE	0.61369438
65	LCK	0.61023827
66	PHKG2	0.60492491
67	PHKG1	0.60492491
68	EIF2AK2	0.58421768
69	MAPK15	0.57405917
70	DAPK2	0.56942845
71	ILK	0.54855147
72	PRKCI	0.53044248
73	EIF2AK1	0.52661182
74	CDK8	0.52657832
75	MAP2K6	0.51871370
76	CSNK2A2	0.50504747
77	PAK3	0.49937057
78	CSNK1G3	0.49899948
79	PRKACA	0.48054979
80	GRK5	0.47401408
81	PLK3	0.46759502
82	CSF1R	0.46657117
83	CAMK1	0.46355339
84	PIM1	0.46086991
85	ADRBK1	0.45830399
86	CAMKK1	0.45319316
87	MATK	0.45003364
88	LRRK2	0.44855041
89	CSNK1G1	0.44753338
90	PRKCD	0.44232998
91	TYK2	0.43862599
92	CSNK1A1	0.41733367
93	AURKB	0.41662832
94	PRKCG	0.40303741
95	DAPK1	0.40001552
96	IGF1R	0.39616969
97	CSNK1G2	0.39428476
98	OBSCN	0.38564173
99	CSNK1A1L	0.38502598
100	AKT3	0.37536780

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.93009072
2	Asthma_Homo sapiens_hsa05310	3.88390374
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.75801602
4	Allograft rejection_Homo sapiens_hsa05330	3.36666379
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.36535196
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.26999590
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.07888511
8	Parkinsons disease_Homo sapiens_hsa05012	2.99458532
9	Proteasome_Homo sapiens_hsa03050	2.80260587
10	Protein export_Homo sapiens_hsa03060	2.51490155
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.47244655
12	Primary immunodeficiency_Homo sapiens_hsa05340	2.37337057
13	Antigen processing and presentation_Homo sapiens_hsa04612	2.08348131
14	Alzheimers disease_Homo sapiens_hsa05010	2.05496994
15	Huntingtons disease_Homo sapiens_hsa05016	1.99316731
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.98947711
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.90511480
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.81823191
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.75844075
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.55086564
21	RNA polymerase_Homo sapiens_hsa03020	1.54366402
22	Homologous recombination_Homo sapiens_hsa03440	1.51459674
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.46943829
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.44811950
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32828003
26	RNA degradation_Homo sapiens_hsa03018	1.23397761
27	Caffeine metabolism_Homo sapiens_hsa00232	1.20012233
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.15939543
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.08884643
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.07019272
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.05210159
32	Basal transcription factors_Homo sapiens_hsa03022	1.05152671
33	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.03982698
34	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.97263033
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.96743236
36	Phototransduction_Homo sapiens_hsa04744	0.96440038
37	Viral myocarditis_Homo sapiens_hsa05416	0.95672519
38	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94912962
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91986242
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89831369
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87072930
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.84986249
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84189526
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82209406
45	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79809670
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77691929
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74264353
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.72802885
49	Sulfur metabolism_Homo sapiens_hsa00920	0.72273367
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.72244596
51	Propanoate metabolism_Homo sapiens_hsa00640	0.67992390
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.67887706
53	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.67652033
54	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.66480070
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66336540
56	Retinol metabolism_Homo sapiens_hsa00830	0.66255815
57	Nicotine addiction_Homo sapiens_hsa05033	0.65866689
58	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.64821979
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.63983946
60	Spliceosome_Homo sapiens_hsa03040	0.62564462
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.62252630
62	One carbon pool by folate_Homo sapiens_hsa00670	0.61005209
63	Purine metabolism_Homo sapiens_hsa00230	0.56274087
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55563794
65	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.54532312
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54275275
67	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.52602508
68	Non-homologous end-joining_Homo sapiens_hsa03450	0.50952527
69	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.50587984
70	Regulation of autophagy_Homo sapiens_hsa04140	0.50462281
71	Mismatch repair_Homo sapiens_hsa03430	0.50102101
72	Peroxisome_Homo sapiens_hsa04146	0.49586880
73	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.48506010
74	Metabolic pathways_Homo sapiens_hsa01100	0.46183577
75	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.45315855
76	Leishmaniasis_Homo sapiens_hsa05140	0.43202760
77	Morphine addiction_Homo sapiens_hsa05032	0.42581083
78	African trypanosomiasis_Homo sapiens_hsa05143	0.41979517
79	Glutathione metabolism_Homo sapiens_hsa00480	0.40872933
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39937128
81	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.38740022
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38347323
83	Mineral absorption_Homo sapiens_hsa04978	0.38239332
84	Base excision repair_Homo sapiens_hsa03410	0.37414996
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37394833
86	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.37086421
87	DNA replication_Homo sapiens_hsa03030	0.36101362
88	Olfactory transduction_Homo sapiens_hsa04740	0.35483128
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33856763
90	Butanoate metabolism_Homo sapiens_hsa00650	0.33181795
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.32460423
92	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.30389675
93	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.29959361
94	RNA transport_Homo sapiens_hsa03013	0.29314069
95	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.28206352
96	Salivary secretion_Homo sapiens_hsa04970	0.24674672
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.22929203
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.21958477
99	Fatty acid degradation_Homo sapiens_hsa00071	0.21913443
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.20855709

RPL21P67

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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