RPL21P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.79456898
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.61537934
3ATP synthesis coupled proton transport (GO:0015986)5.61537934
4DNA deamination (GO:0045006)5.51048946
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.06985735
6respiratory electron transport chain (GO:0022904)4.56647202
7ribosomal small subunit assembly (GO:0000028)4.53374978
8electron transport chain (GO:0022900)4.53020062
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.21646568
10cytidine deamination (GO:0009972)4.18217023
11cytidine metabolic process (GO:0046087)4.18217023
12cytidine catabolic process (GO:0006216)4.18217023
13protein neddylation (GO:0045116)4.14793887
14protein complex biogenesis (GO:0070271)3.98277106
15viral transcription (GO:0019083)3.83853563
16translational termination (GO:0006415)3.71618790
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65602669
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.64989706
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.64989706
20pyrimidine ribonucleoside catabolic process (GO:0046133)3.63338573
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60317126
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.60317126
23NADH dehydrogenase complex assembly (GO:0010257)3.60317126
24cotranslational protein targeting to membrane (GO:0006613)3.59161677
25protein targeting to ER (GO:0045047)3.58359956
26hydrogen ion transmembrane transport (GO:1902600)3.53966493
27mitochondrial respiratory chain complex assembly (GO:0033108)3.53342064
28protein localization to endoplasmic reticulum (GO:0070972)3.42993984
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.41921352
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.41909072
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.34727444
32proton transport (GO:0015992)3.33958868
33translational elongation (GO:0006414)3.32927146
34behavioral response to nicotine (GO:0035095)3.30251183
35platelet dense granule organization (GO:0060155)3.29839351
36ATP biosynthetic process (GO:0006754)3.29608825
37hydrogen transport (GO:0006818)3.28281195
38chaperone-mediated protein transport (GO:0072321)3.17780198
39respiratory chain complex IV assembly (GO:0008535)3.17513122
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16227779
41water-soluble vitamin biosynthetic process (GO:0042364)3.14774604
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.10756484
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.09453609
44sequestering of actin monomers (GO:0042989)3.07946016
45cytochrome complex assembly (GO:0017004)3.07846590
46negative regulation of mast cell activation (GO:0033004)3.03632284
47proteasome assembly (GO:0043248)3.00183969
48indole-containing compound catabolic process (GO:0042436)2.97315943
49indolalkylamine catabolic process (GO:0046218)2.97315943
50tryptophan catabolic process (GO:0006569)2.97315943
51regulation of cellular amino acid metabolic process (GO:0006521)2.93139932
52kynurenine metabolic process (GO:0070189)2.91935710
53termination of RNA polymerase III transcription (GO:0006386)2.91392513
54transcription elongation from RNA polymerase III promoter (GO:0006385)2.91392513
55GPI anchor metabolic process (GO:0006505)2.85172237
56maturation of SSU-rRNA (GO:0030490)2.84946324
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.84145490
58regulation of regulatory T cell differentiation (GO:0045589)2.83179937
59translation (GO:0006412)2.80199122
60positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.78634435
61GPI anchor biosynthetic process (GO:0006506)2.76815251
62ribosomal large subunit biogenesis (GO:0042273)2.76304030
63mannosylation (GO:0097502)2.76251086
64preassembly of GPI anchor in ER membrane (GO:0016254)2.72125649
65response to pheromone (GO:0019236)2.70273140
66cellular response to interleukin-15 (GO:0071350)2.70188778
67indolalkylamine metabolic process (GO:0006586)2.69172293
68viral life cycle (GO:0019058)2.69118170
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.68780431
70cellular protein complex disassembly (GO:0043624)2.68717185
71positive regulation of T cell mediated cytotoxicity (GO:0001916)2.65718203
72regulation of chronic inflammatory response (GO:0002676)2.64391572
73protein-cofactor linkage (GO:0018065)2.63594474
74mast cell activation (GO:0045576)2.62527724
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.59626680
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.59626680
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.59626680
78regulation of isotype switching to IgG isotypes (GO:0048302)2.59428259
79peptidyl-histidine modification (GO:0018202)2.57930962
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.56134912
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.56134912
82positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.55982981
83interferon-gamma production (GO:0032609)2.55405043
84ribonucleoside triphosphate biosynthetic process (GO:0009201)2.55134687
85translational initiation (GO:0006413)2.54728442
86negative T cell selection (GO:0043383)2.54144610
87tryptophan metabolic process (GO:0006568)2.52816750
88regulation of T cell mediated cytotoxicity (GO:0001914)2.52811432
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.52697807
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51747510
91GTP biosynthetic process (GO:0006183)2.51057407
92regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.51053116
93cellular ketone body metabolic process (GO:0046950)2.50751394
94positive regulation of calcium-mediated signaling (GO:0050850)2.49373262
95regulation of interleukin-8 secretion (GO:2000482)2.48176496
96RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.47295514
97S-adenosylmethionine metabolic process (GO:0046500)2.47215822
98regulation of B cell receptor signaling pathway (GO:0050855)2.45553794
99antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.43675395
100sulfation (GO:0051923)2.43482564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.39073402
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.25499878
3VDR_22108803_ChIP-Seq_LS180_Human3.02603198
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99242828
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.86016202
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.79039859
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59643873
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.55132914
9ZNF274_21170338_ChIP-Seq_K562_Hela2.47543490
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46277720
11IGF1R_20145208_ChIP-Seq_DFB_Human2.37319850
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.27072694
13VDR_23849224_ChIP-Seq_CD4+_Human2.25937508
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.18019747
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16563096
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15236289
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05030770
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01469509
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99195737
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97350073
21EZH2_22144423_ChIP-Seq_EOC_Human1.89917279
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89343827
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.84088434
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82987425
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82178402
26ELK1_19687146_ChIP-ChIP_HELA_Human1.78165835
27TP53_22573176_ChIP-Seq_HFKS_Human1.71001347
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65555467
29FOXP3_21729870_ChIP-Seq_TREG_Human1.64848733
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.60589684
31MYC_18940864_ChIP-ChIP_HL60_Human1.57459619
32EWS_26573619_Chip-Seq_HEK293_Human1.53544429
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51949070
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51882640
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.50129737
36GATA3_26560356_Chip-Seq_TH2_Human1.48946227
37TAF15_26573619_Chip-Seq_HEK293_Human1.48923010
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.48711430
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.48711430
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48264484
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44318490
42ER_23166858_ChIP-Seq_MCF-7_Human1.43132504
43AR_20517297_ChIP-Seq_VCAP_Human1.42358597
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42107413
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.38723875
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.37862178
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34099989
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33265817
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32745712
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32534559
51P300_19829295_ChIP-Seq_ESCs_Human1.32104354
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29916000
53FUS_26573619_Chip-Seq_HEK293_Human1.28574368
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27222701
55NANOG_19829295_ChIP-Seq_ESCs_Human1.25650938
56SOX2_19829295_ChIP-Seq_ESCs_Human1.25650938
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.24591390
58GBX2_23144817_ChIP-Seq_PC3_Human1.24586227
59MYB_26560356_Chip-Seq_TH2_Human1.22334582
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21270674
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20315345
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18316957
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18134076
64CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.17058311
65NCOR_22424771_ChIP-Seq_293T_Human1.16965571
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16943957
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16796578
68CBP_20019798_ChIP-Seq_JUKART_Human1.16796578
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15925128
70NANOG_20526341_ChIP-Seq_ESCs_Human1.15782532
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15681218
72ERG_20517297_ChIP-Seq_VCAP_Human1.14035803
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.13987392
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.13443033
75TAF2_19829295_ChIP-Seq_ESCs_Human1.13247937
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11868801
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09882352
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09544530
79EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09118792
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08271882
81MYC_19829295_ChIP-Seq_ESCs_Human1.07668140
82RUNX_20019798_ChIP-Seq_JUKART_Human1.05501320
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.04634086
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.03814625
85GATA3_27048872_Chip-Seq_THYMUS_Human1.02235082
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01428289
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00988910
88HTT_18923047_ChIP-ChIP_STHdh_Human0.99952875
89BCAT_22108803_ChIP-Seq_LS180_Human0.99080804
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99078663
91IRF1_19129219_ChIP-ChIP_H3396_Human0.99041201
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98811507
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98179414
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98161906
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95941910
96ERA_21632823_ChIP-Seq_H3396_Human0.94373631
97GATA6_21074721_ChIP-Seq_CACO-2_Human0.94090947
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93979596
99TCF4_22108803_ChIP-Seq_LS180_Human0.93521340
100HOXB7_26014856_ChIP-Seq_BT474_Human0.93081260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.15598493
2MP0009379_abnormal_foot_pigmentation3.16398038
3MP0001835_abnormal_antigen_presentation3.14545134
4MP0006072_abnormal_retinal_apoptosis2.44558924
5MP0002837_dystrophic_cardiac_calcinosis2.37845353
6MP0008877_abnormal_DNA_methylation2.14609081
7MP0002102_abnormal_ear_morphology2.14550280
8MP0008875_abnormal_xenobiotic_pharmacok2.09691455
9MP0009785_altered_susceptibility_to2.08047990
10MP0008872_abnormal_physiological_respon2.01988070
11MP0002163_abnormal_gland_morphology2.00782231
12MP0002876_abnormal_thyroid_physiology1.99097039
13MP0006292_abnormal_olfactory_placode1.97302981
14MP0005645_abnormal_hypothalamus_physiol1.97229758
15MP0003195_calcinosis1.94704485
16MP0005551_abnormal_eye_electrophysiolog1.87385877
17MP0005646_abnormal_pituitary_gland1.79538692
18MP0004142_abnormal_muscle_tone1.75062352
19MP0000372_irregular_coat_pigmentation1.73976095
20MP0001800_abnormal_humoral_immune1.68737067
21MP0003011_delayed_dark_adaptation1.68359297
22MP0003646_muscle_fatigue1.66844893
23MP0003806_abnormal_nucleotide_metabolis1.65707422
24MP0005000_abnormal_immune_tolerance1.65456681
25MP0001986_abnormal_taste_sensitivity1.63081076
26MP0001968_abnormal_touch/_nociception1.62837574
27MP0005075_abnormal_melanosome_morpholog1.62813886
28MP0002166_altered_tumor_susceptibility1.60299178
29MP0005253_abnormal_eye_physiology1.56766857
30MP0002148_abnormal_hypersensitivity_rea1.54606425
31MP0004885_abnormal_endolymph1.53522024
32MP0000685_abnormal_immune_system1.52932297
33MP0001905_abnormal_dopamine_level1.50953712
34MP0001919_abnormal_reproductive_system1.48887763
35MP0005379_endocrine/exocrine_gland_phen1.45562153
36MP0001873_stomach_inflammation1.45116040
37MP0005387_immune_system_phenotype1.41485253
38MP0001790_abnormal_immune_system1.41485253
39MP0002006_tumorigenesis1.41343229
40MP0002723_abnormal_immune_serum1.41049514
41MP0009333_abnormal_splenocyte_physiolog1.40475447
42MP0002736_abnormal_nociception_after1.39695175
43MP0003878_abnormal_ear_physiology1.38306879
44MP0005377_hearing/vestibular/ear_phenot1.38306879
45MP0004145_abnormal_muscle_electrophysio1.35884442
46MP0003866_abnormal_defecation1.34228512
47MP0003763_abnormal_thymus_physiology1.32395821
48MP0002420_abnormal_adaptive_immunity1.30091605
49MP0005389_reproductive_system_phenotype1.29759795
50MP0001819_abnormal_immune_cell1.29492373
51MP0002452_abnormal_antigen_presenting1.27433071
52MP0002277_abnormal_respiratory_mucosa1.26844512
53MP0004147_increased_porphyrin_level1.26074546
54MP0003787_abnormal_imprinting1.25356353
55MP0003724_increased_susceptibility_to1.24998935
56MP0006082_CNS_inflammation1.23847153
57MP0003880_abnormal_central_pattern1.22190280
58MP0005084_abnormal_gallbladder_morpholo1.21902801
59MP0009764_decreased_sensitivity_to1.21614426
60MP0002638_abnormal_pupillary_reflex1.21373329
61MP0002138_abnormal_hepatobiliary_system1.19089366
62MP0005025_abnormal_response_to1.17802200
63MP0006276_abnormal_autonomic_nervous1.16595937
64MP0009745_abnormal_behavioral_response1.13768231
65MP0002272_abnormal_nervous_system1.11351839
66MP0001984_abnormal_olfaction1.06086648
67MP0006036_abnormal_mitochondrial_physio1.05951786
68MP0008995_early_reproductive_senescence1.05716033
69MP0001485_abnormal_pinna_reflex0.99963099
70MP0010386_abnormal_urinary_bladder0.98828260
71MP0005410_abnormal_fertilization0.95943284
72MP0001970_abnormal_pain_threshold0.94167025
73MP0002693_abnormal_pancreas_physiology0.92294438
74MP0002938_white_spotting0.92251757
75MP0005636_abnormal_mineral_homeostasis0.92093049
76MP0001529_abnormal_vocalization0.91720315
77MP0002095_abnormal_skin_pigmentation0.91182084
78MP0010155_abnormal_intestine_physiology0.91137399
79MP0001845_abnormal_inflammatory_respons0.90542283
80MP0001501_abnormal_sleep_pattern0.89471794
81MP0001765_abnormal_ion_homeostasis0.89304350
82MP0000716_abnormal_immune_system0.89293255
83MP0000631_abnormal_neuroendocrine_gland0.89112312
84MP0004043_abnormal_pH_regulation0.83086827
85MP0003252_abnormal_bile_duct0.82898802
86MP0003283_abnormal_digestive_organ0.82823667
87MP0001764_abnormal_homeostasis0.82722870
88MP0009046_muscle_twitch0.82416421
89MP0005085_abnormal_gallbladder_physiolo0.82216504
90MP0005332_abnormal_amino_acid0.81345914
91MP0001486_abnormal_startle_reflex0.79436895
92MP0002933_joint_inflammation0.79436704
93MP0002234_abnormal_pharynx_morphology0.78560701
94MP0004742_abnormal_vestibular_system0.76371222
95MP0003786_premature_aging0.76263199
96MP0002160_abnormal_reproductive_system0.74987562
97MP0003638_abnormal_response/metabolism_0.74413678
98MP0002398_abnormal_bone_marrow0.72314792
99MP0003436_decreased_susceptibility_to0.72091252
100MP0003186_abnormal_redox_activity0.70776468

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.84382063
2Mitochondrial inheritance (HP:0001427)4.54692902
3Abnormal mitochondria in muscle tissue (HP:0008316)4.29148091
4Progressive macrocephaly (HP:0004481)4.15669804
5Acute encephalopathy (HP:0006846)4.11306277
6Hepatocellular necrosis (HP:0001404)3.97125912
7Increased CSF lactate (HP:0002490)3.91341520
83-Methylglutaconic aciduria (HP:0003535)3.86302514
9IgG deficiency (HP:0004315)3.69844201
10Congenital stationary night blindness (HP:0007642)3.65631954
11Hepatic necrosis (HP:0002605)3.48990601
12Pancreatic cysts (HP:0001737)3.47520189
13Congenital, generalized hypertrichosis (HP:0004540)3.29315226
14Increased hepatocellular lipid droplets (HP:0006565)3.29203822
15Aplastic anemia (HP:0001915)3.27941398
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.17524112
17Lipid accumulation in hepatocytes (HP:0006561)3.15207143
18Cerebral edema (HP:0002181)3.09379529
19Stomatitis (HP:0010280)2.96384400
20Abnormality of midbrain morphology (HP:0002418)2.95867724
21Molar tooth sign on MRI (HP:0002419)2.95867724
22Elevated erythrocyte sedimentation rate (HP:0003565)2.94243229
23Optic disc pallor (HP:0000543)2.90379808
24Pancreatic fibrosis (HP:0100732)2.87369891
25Abnormal rod and cone electroretinograms (HP:0008323)2.87318472
26True hermaphroditism (HP:0010459)2.79016929
27Abolished electroretinogram (ERG) (HP:0000550)2.78680483
28Methylmalonic acidemia (HP:0002912)2.75306874
29Increased intramyocellular lipid droplets (HP:0012240)2.73893060
30Hypoproteinemia (HP:0003075)2.73517378
31Renal Fanconi syndrome (HP:0001994)2.72743535
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.72150661
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.72150661
34Attenuation of retinal blood vessels (HP:0007843)2.65830726
35Severe combined immunodeficiency (HP:0004430)2.48025044
36Lactic acidosis (HP:0003128)2.45624687
37Increased serum lactate (HP:0002151)2.44685585
38Exertional dyspnea (HP:0002875)2.44174173
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.40570268
40Increased muscle lipid content (HP:0009058)2.33400449
41Respiratory failure (HP:0002878)2.32895754
42Decreased central vision (HP:0007663)2.28294549
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.28160412
44Abnormality of cells of the erythroid lineage (HP:0012130)2.27666145
45T lymphocytopenia (HP:0005403)2.27564045
46Thyroiditis (HP:0100646)2.27477882
47Methylmalonic aciduria (HP:0012120)2.27459848
48Abnormality of T cell number (HP:0011839)2.25447479
49Nephronophthisis (HP:0000090)2.22325518
50Abnormal number of erythroid precursors (HP:0012131)2.19088838
51Abnormality of the prostate (HP:0008775)2.17313583
52Lethargy (HP:0001254)2.17306523
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15692588
54Hypothermia (HP:0002045)2.13525026
55Abnormality of the renal cortex (HP:0011035)2.12392065
56Macrocytic anemia (HP:0001972)2.11649607
57Abnormality of T cells (HP:0002843)2.10929914
58Leukodystrophy (HP:0002415)2.08940717
59Increased IgM level (HP:0003496)2.04349059
60Pendular nystagmus (HP:0012043)2.01471542
61Sclerocornea (HP:0000647)2.01394336
62Abnormality of B cell number (HP:0010975)2.00481159
63Constricted visual fields (HP:0001133)1.97298767
64Renal cortical cysts (HP:0000803)1.95247573
65Aplasia/hypoplasia of the uterus (HP:0008684)1.92901361
66Reticulocytopenia (HP:0001896)1.91842451
67Abnormal albumin level (HP:0012116)1.91829966
68Hypoalbuminemia (HP:0003073)1.91829966
69Exercise intolerance (HP:0003546)1.89702779
70Medial flaring of the eyebrow (HP:0010747)1.89009193
71Chronic diarrhea (HP:0002028)1.87402453
72Pancytopenia (HP:0001876)1.84881291
73Male pseudohermaphroditism (HP:0000037)1.84823739
74Cystic liver disease (HP:0006706)1.82514302
75Abnormal drinking behavior (HP:0030082)1.82223176
76Polydipsia (HP:0001959)1.82223176
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.80982220
78Abnormality of renal resorption (HP:0011038)1.80779112
79Hyperglycinemia (HP:0002154)1.80450837
80Abnormality of the renal medulla (HP:0100957)1.80226008
81B lymphocytopenia (HP:0010976)1.79895687
82Abnormality of urine glucose concentration (HP:0011016)1.78375572
83Glycosuria (HP:0003076)1.78375572
84Ketosis (HP:0001946)1.78319919
85Abnormality of eosinophils (HP:0001879)1.78253468
86Hypomagnesemia (HP:0002917)1.76701403
87Combined immunodeficiency (HP:0005387)1.76279293
88Increased corneal curvature (HP:0100692)1.75163565
89Keratoconus (HP:0000563)1.75163565
90Abnormality of vitamin B metabolism (HP:0004340)1.73879836
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72757224
92Abnormality of alanine metabolism (HP:0010916)1.72757224
93Hyperalaninemia (HP:0003348)1.72757224
94Absent thumb (HP:0009777)1.72552399
95Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.72342438
96Type II lissencephaly (HP:0007260)1.71054854
97Cerebral palsy (HP:0100021)1.68917018
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.68719272
99Abnormality of the vitamin B12 metabolism (HP:0004341)1.68304990
100Asplenia (HP:0001746)1.68034771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.34487511
2MAP4K23.10948166
3FRK3.07427318
4KDR2.99146316
5GRK12.57336024
6ADRBK22.56443110
7ZAK2.53554674
8TLK12.46889733
9CDK192.44031545
10MAP3K122.29875317
11TAOK32.20230137
12BCKDK2.11751125
13NUAK12.05406508
14TESK22.05179209
15MAP4K11.95293918
16VRK21.88554844
17WNK31.85393177
18WNK41.79270901
19PINK11.77518336
20BMPR21.69466605
21ITK1.61216938
22STK161.57471695
23TEC1.51701105
24NME11.37219549
25MYLK1.33848643
26MST41.31421441
27TIE11.27294193
28GRK61.25204314
29VRK11.21772128
30PASK1.21546968
31IKBKB1.20307542
32INSRR1.17319197
33MUSK1.14842441
34SCYL21.11882990
35OXSR11.11853820
36LIMK11.11633517
37FES1.09459176
38ERBB31.09370068
39SYK1.03612563
40DYRK21.00895827
41CSF1R0.93582687
42BTK0.87802184
43LYN0.87458258
44KIT0.87335005
45PHKG20.83859830
46PHKG10.83859830
47LCK0.83758939
48CAMKK20.81757272
49GRK70.76280602
50PRKCQ0.75540266
51BMPR1B0.74252435
52TRIM280.73946015
53CSNK1G30.73347556
54RPS6KA50.72624687
55ADRBK10.72000324
56PIK3CA0.69808685
57DAPK10.68661110
58TNK20.67944846
59OBSCN0.65524499
60IKBKE0.65120524
61TRPM70.62092737
62DAPK20.61846471
63STK390.60781507
64CSNK1G20.60667740
65ILK0.60575630
66EIF2AK30.59236699
67MAPK130.57388284
68IGF1R0.57036808
69CSNK1G10.54895761
70PRKCE0.50993020
71DAPK30.50326074
72PRKACA0.49662649
73MATK0.49366481
74MAP3K40.49123204
75PIM10.48383721
76MAP2K60.47717432
77CDK80.46578477
78ACVR1B0.46321416
79PLK40.45456223
80PRKCA0.45429591
81FLT30.44957634
82BUB10.44529140
83PAK30.43726346
84MAP2K70.42119626
85PRKCG0.39482230
86CSK0.38960150
87CAMK2A0.38527703
88MAP3K110.38232643
89CSNK1A10.38131986
90CSNK1A1L0.37781766
91MAPKAPK30.37745440
92CSNK2A10.37551371
93PIK3CG0.37245948
94CSNK2A20.36383837
95SRPK10.34558205
96NEK10.33786440
97CAMKK10.33595993
98ROCK10.33162252
99EIF2AK20.32236697
100ERBB20.32077423

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.18963245
2Ribosome_Homo sapiens_hsa030103.48942606
3Proteasome_Homo sapiens_hsa030503.46771066
4Parkinsons disease_Homo sapiens_hsa050123.29412005
5Asthma_Homo sapiens_hsa053103.02430268
6Allograft rejection_Homo sapiens_hsa053302.85417746
7Primary immunodeficiency_Homo sapiens_hsa053402.84066143
8Autoimmune thyroid disease_Homo sapiens_hsa053202.79271900
9Graft-versus-host disease_Homo sapiens_hsa053322.65102906
10Protein export_Homo sapiens_hsa030602.62652361
11Type I diabetes mellitus_Homo sapiens_hsa049402.49803529
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.45398362
13Alzheimers disease_Homo sapiens_hsa050102.25712641
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08432391
15Huntingtons disease_Homo sapiens_hsa050162.07596553
16RNA polymerase_Homo sapiens_hsa030201.99085685
17Cardiac muscle contraction_Homo sapiens_hsa042601.95685659
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82232335
19Antigen processing and presentation_Homo sapiens_hsa046121.80271060
20Phototransduction_Homo sapiens_hsa047441.76149784
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53797741
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53038407
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46710670
24Linoleic acid metabolism_Homo sapiens_hsa005911.43395862
25Rheumatoid arthritis_Homo sapiens_hsa053231.41655037
26Homologous recombination_Homo sapiens_hsa034401.40336022
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.27041769
28RNA degradation_Homo sapiens_hsa030181.25287283
29Hematopoietic cell lineage_Homo sapiens_hsa046401.24602898
30Nitrogen metabolism_Homo sapiens_hsa009101.21214732
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13520378
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10331731
33Caffeine metabolism_Homo sapiens_hsa002321.08334200
34One carbon pool by folate_Homo sapiens_hsa006701.02053520
35Basal transcription factors_Homo sapiens_hsa030221.01862043
36Collecting duct acid secretion_Homo sapiens_hsa049660.96690202
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92072439
38Tryptophan metabolism_Homo sapiens_hsa003800.91701120
39Viral myocarditis_Homo sapiens_hsa054160.87334841
40Chemical carcinogenesis_Homo sapiens_hsa052040.87105150
41Propanoate metabolism_Homo sapiens_hsa006400.86305173
42Butanoate metabolism_Homo sapiens_hsa006500.86061635
43Regulation of autophagy_Homo sapiens_hsa041400.84943829
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83207503
45Arachidonic acid metabolism_Homo sapiens_hsa005900.82138973
46Pyrimidine metabolism_Homo sapiens_hsa002400.81056233
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80306029
48Nucleotide excision repair_Homo sapiens_hsa034200.77851813
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77343342
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76400441
51Peroxisome_Homo sapiens_hsa041460.75468377
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74504408
53Nicotine addiction_Homo sapiens_hsa050330.73881124
54T cell receptor signaling pathway_Homo sapiens_hsa046600.72633645
55Olfactory transduction_Homo sapiens_hsa047400.71708030
56Purine metabolism_Homo sapiens_hsa002300.71456338
57Staphylococcus aureus infection_Homo sapiens_hsa051500.70137236
58Retinol metabolism_Homo sapiens_hsa008300.69958227
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68837805
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.68555357
61Mismatch repair_Homo sapiens_hsa034300.68517691
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67258637
63Systemic lupus erythematosus_Homo sapiens_hsa053220.65001813
64Ether lipid metabolism_Homo sapiens_hsa005650.64958161
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.64098204
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63736700
67Fanconi anemia pathway_Homo sapiens_hsa034600.59963201
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55940790
69Taste transduction_Homo sapiens_hsa047420.55562842
70Metabolic pathways_Homo sapiens_hsa011000.54815220
71Spliceosome_Homo sapiens_hsa030400.53234568
72Fat digestion and absorption_Homo sapiens_hsa049750.51995735
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50508256
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48518695
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46329935
76Sulfur metabolism_Homo sapiens_hsa009200.45646483
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44077889
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.43648037
79Morphine addiction_Homo sapiens_hsa050320.40545764
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.40130050
81RNA transport_Homo sapiens_hsa030130.38512964
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37632240
83Glutathione metabolism_Homo sapiens_hsa004800.37115157
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36170498
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35736332
86DNA replication_Homo sapiens_hsa030300.35588316
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.32576238
88Salivary secretion_Homo sapiens_hsa049700.32232848
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27247683
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25411096
91Leishmaniasis_Homo sapiens_hsa051400.25295904
92Selenocompound metabolism_Homo sapiens_hsa004500.24724432
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24165200
94Base excision repair_Homo sapiens_hsa034100.23223074
95Serotonergic synapse_Homo sapiens_hsa047260.23222113
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22839214
97GABAergic synapse_Homo sapiens_hsa047270.22226244
98Vitamin digestion and absorption_Homo sapiens_hsa049770.21719559
99Measles_Homo sapiens_hsa051620.19537215
100ABC transporters_Homo sapiens_hsa020100.19332873

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »