ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.22998086
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.08830202
3	ATP synthesis coupled proton transport (GO:0015986)	6.08830202
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.44307374
5	DNA deamination (GO:0045006)	4.39218375
6	respiratory electron transport chain (GO:0022904)	4.17692903
7	electron transport chain (GO:0022900)	4.17097821
8	platelet dense granule organization (GO:0060155)	3.86153363
9	protein neddylation (GO:0045116)	3.79642391
10	ribosomal small subunit assembly (GO:0000028)	3.76368027
11	GPI anchor biosynthetic process (GO:0006506)	3.76077418
12	GPI anchor metabolic process (GO:0006505)	3.75880985
13	preassembly of GPI anchor in ER membrane (GO:0016254)	3.70996433
14	viral transcription (GO:0019083)	3.69177491
15	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.61499628
16	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.61499628
17	translational termination (GO:0006415)	3.56696269
18	kynurenine metabolic process (GO:0070189)	3.54269758
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.50338994
20	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.47544659
21	respiratory chain complex IV assembly (GO:0008535)	3.45201204
22	cotranslational protein targeting to membrane (GO:0006613)	3.43488504
23	protein targeting to ER (GO:0045047)	3.42187269
24	behavioral response to nicotine (GO:0035095)	3.41498089
25	ATP biosynthetic process (GO:0006754)	3.40718690
26	indole-containing compound catabolic process (GO:0042436)	3.40391684
27	indolalkylamine catabolic process (GO:0046218)	3.40391684
28	tryptophan catabolic process (GO:0006569)	3.40391684
29	protein complex biogenesis (GO:0070271)	3.40221388
30	negative regulation of heart rate (GO:0010459)	3.36740092
31	mast cell activation (GO:0045576)	3.34114115
32	protein localization to endoplasmic reticulum (GO:0070972)	3.30253247
33	hydrogen ion transmembrane transport (GO:1902600)	3.29549211
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.28052675
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.28052675
36	NADH dehydrogenase complex assembly (GO:0010257)	3.28052675
37	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.26354230
38	positive regulation of prostaglandin secretion (GO:0032308)	3.24477802
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.23893873
40	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.20746974
41	regulation of hypersensitivity (GO:0002883)	3.20237662
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.19241458
43	proton transport (GO:0015992)	3.18160058
44	response to pheromone (GO:0019236)	3.15410298
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.13617299
46	hydrogen transport (GO:0006818)	3.12806755
47	chaperone-mediated protein transport (GO:0072321)	3.08914777
48	cellular response to interleukin-15 (GO:0071350)	3.06890480
49	regulation of regulatory T cell differentiation (GO:0045589)	3.05033123
50	translational elongation (GO:0006414)	3.01531266
51	mitochondrial respiratory chain complex assembly (GO:0033108)	2.96521993
52	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.94580447
53	cytochrome complex assembly (GO:0017004)	2.93604663
54	indolalkylamine metabolic process (GO:0006586)	2.93126710
55	positive regulation of fatty acid transport (GO:2000193)	2.87628078
56	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.82233125
57	detection of light stimulus involved in visual perception (GO:0050908)	2.81816822
58	detection of light stimulus involved in sensory perception (GO:0050962)	2.81816822
59	tryptophan metabolic process (GO:0006568)	2.80647959
60	mannosylation (GO:0097502)	2.74705651
61	mast cell activation involved in immune response (GO:0002279)	2.70985443
62	mast cell degranulation (GO:0043303)	2.70985443
63	ribosomal large subunit biogenesis (GO:0042273)	2.69589867
64	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.68737797
65	regulation of germinal center formation (GO:0002634)	2.68693445
66	regulation of interleukin-8 secretion (GO:2000482)	2.66360923
67	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.66336402
68	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.65746694
69	regulation of prostaglandin secretion (GO:0032306)	2.65197459
70	viral life cycle (GO:0019058)	2.61697614
71	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.60893255
72	negative regulation of mast cell activation (GO:0033004)	2.59639031
73	positive regulation of icosanoid secretion (GO:0032305)	2.58005141
74	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.57764703
75	GTP biosynthetic process (GO:0006183)	2.57503210
76	cytidine metabolic process (GO:0046087)	2.56880379
77	cytidine catabolic process (GO:0006216)	2.56880379
78	cytidine deamination (GO:0009972)	2.56880379
79	protein prenylation (GO:0018342)	2.56854889
80	prenylation (GO:0097354)	2.56854889
81	translation (GO:0006412)	2.56821595
82	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.54149432
83	maturation of SSU-rRNA (GO:0030490)	2.54139597
84	cellular protein complex disassembly (GO:0043624)	2.52488953
85	peptidyl-histidine modification (GO:0018202)	2.50591088
86	regulation of immunoglobulin secretion (GO:0051023)	2.50583418
87	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.50179557
88	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.49536770
89	regulation of T cell mediated cytotoxicity (GO:0001914)	2.48783961
90	C-terminal protein lipidation (GO:0006501)	2.48549624
91	interferon-gamma production (GO:0032609)	2.46629023
92	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.45864921
93	spliceosomal complex assembly (GO:0000245)	2.45700472
94	termination of RNA polymerase III transcription (GO:0006386)	2.45585614
95	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.45585614
96	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.45279279
97	regulation of memory T cell differentiation (GO:0043380)	2.44656311
98	adaptation of signaling pathway (GO:0023058)	2.43173195
99	regulation of T cell receptor signaling pathway (GO:0050856)	2.40246588
100	positive regulation of protein homodimerization activity (GO:0090073)	2.40033907

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.97246127
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.08337282
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.05766152
4	VDR_22108803_ChIP-Seq_LS180_Human	2.90813126
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.57144095
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.43482292
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.38979022
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.36543320
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.30671572
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.30440485
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.22483058
12	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.13957178
13	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.02824232
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.02023795
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.95182785
16	VDR_23849224_ChIP-Seq_CD4+_Human	1.91318882
17	FUS_26573619_Chip-Seq_HEK293_Human	1.87311403
18	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.81670201
19	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.80161035
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80036288
21	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.78615591
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78432488
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.66603648
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.66091005
25	GATA3_26560356_Chip-Seq_TH2_Human	1.65415521
26	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.64989142
27	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.64989142
28	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.62994861
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.61198565
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58722239
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58378670
32	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.58135903
33	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.56336205
34	EWS_26573619_Chip-Seq_HEK293_Human	1.55812980
35	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.55496952
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.52691130
37	P300_19829295_ChIP-Seq_ESCs_Human	1.52283759
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.50293456
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49603650
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.49467268
41	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.49193698
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.48309468
43	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.46009112
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.44631698
45	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.44292190
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44161031
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44161031
48	AR_20517297_ChIP-Seq_VCAP_Human	1.41840314
49	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.40493041
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36230160
51	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.35912152
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35811088
53	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.35441869
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34260129
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.32835773
56	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.30933124
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30115393
58	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.30028323
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.29555918
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28423405
61	GBX2_23144817_ChIP-Seq_PC3_Human	1.27033799
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26826147
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26338642
64	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.23214546
65	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.22135384
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.21670355
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21670355
68	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21626319
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.20259044
70	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.18340194
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17548919
72	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16462222
73	RUNX_20019798_ChIP-Seq_JUKART_Human	1.16277146
74	NCOR_22424771_ChIP-Seq_293T_Human	1.14603435
75	NANOG_20526341_ChIP-Seq_ESCs_Human	1.13571506
76	MYB_26560356_Chip-Seq_TH2_Human	1.12548960
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10333124
78	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.09472951
79	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09318164
80	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.08969427
81	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.07932005
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.07896286
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.07541903
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07069154
85	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.06497177
86	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.06438892
87	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.06280030
88	GATA3_27048872_Chip-Seq_THYMUS_Human	1.04151743
89	ERG_20517297_ChIP-Seq_VCAP_Human	1.03394648
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98644220
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96832154
92	GATA3_26560356_Chip-Seq_TH1_Human	0.96806811
93	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95709844
94	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.93597504
95	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.91513208
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.91385362
97	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.91164434
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90992967
99	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.90766952
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.89834553

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	3.82493840
2	MP0005671_abnormal_response_to	3.73105821
3	MP0006072_abnormal_retinal_apoptosis	3.05977317
4	MP0009379_abnormal_foot_pigmentation	2.45603303
5	MP0008877_abnormal_DNA_methylation	2.27301583
6	MP0006292_abnormal_olfactory_placode	2.18877230
7	MP0002163_abnormal_gland_morphology	2.17742101
8	MP0003724_increased_susceptibility_to	2.12071899
9	MP0005075_abnormal_melanosome_morpholog	2.08671516
10	MP0008872_abnormal_physiological_respon	2.06847691
11	MP0001800_abnormal_humoral_immune	1.95584648
12	MP0002166_altered_tumor_susceptibility	1.91483828
13	MP0002148_abnormal_hypersensitivity_rea	1.89657512
14	MP0005253_abnormal_eye_physiology	1.87229857
15	MP0005000_abnormal_immune_tolerance	1.84490192
16	MP0004142_abnormal_muscle_tone	1.83547970
17	MP0003880_abnormal_central_pattern	1.82809012
18	MP0003646_muscle_fatigue	1.75584476
19	MP0005379_endocrine/exocrine_gland_phen	1.72901867
20	MP0000372_irregular_coat_pigmentation	1.72889226
21	MP0000685_abnormal_immune_system	1.72137760
22	MP0005551_abnormal_eye_electrophysiolog	1.68244839
23	MP0002102_abnormal_ear_morphology	1.67387962
24	MP0003195_calcinosis	1.67306021
25	MP0009764_decreased_sensitivity_to	1.66927697
26	MP0002876_abnormal_thyroid_physiology	1.63946057
27	MP0009785_altered_susceptibility_to	1.63733680
28	MP0002723_abnormal_immune_serum	1.58287265
29	MP0009333_abnormal_splenocyte_physiolog	1.54697203
30	MP0002006_tumorigenesis	1.51172183
31	MP0004145_abnormal_muscle_electrophysio	1.49947746
32	MP0001790_abnormal_immune_system	1.44931362
33	MP0005387_immune_system_phenotype	1.44931362
34	MP0003787_abnormal_imprinting	1.42533972
35	MP0002837_dystrophic_cardiac_calcinosis	1.41954702
36	MP0002452_abnormal_antigen_presenting	1.41771596
37	MP0001986_abnormal_taste_sensitivity	1.39852411
38	MP0004147_increased_porphyrin_level	1.39355318
39	MP0008875_abnormal_xenobiotic_pharmacok	1.37642714
40	MP0005646_abnormal_pituitary_gland	1.34950701
41	MP0001529_abnormal_vocalization	1.34290962
42	MP0001919_abnormal_reproductive_system	1.34069186
43	MP0008995_early_reproductive_senescence	1.33643497
44	MP0001819_abnormal_immune_cell	1.31208695
45	MP0002420_abnormal_adaptive_immunity	1.30477414
46	MP0002138_abnormal_hepatobiliary_system	1.28716251
47	MP0002234_abnormal_pharynx_morphology	1.26806608
48	MP0005084_abnormal_gallbladder_morpholo	1.26589354
49	MP0001968_abnormal_touch/_nociception	1.23017943
50	MP0004885_abnormal_endolymph	1.21278122
51	MP0005645_abnormal_hypothalamus_physiol	1.19306474
52	MP0006082_CNS_inflammation	1.19069681
53	MP0005367_renal/urinary_system_phenotyp	1.17475359
54	MP0000516_abnormal_urinary_system	1.17475359
55	MP0001984_abnormal_olfaction	1.17235243
56	MP0003866_abnormal_defecation	1.16252908
57	MP0005025_abnormal_response_to	1.15457714
58	MP0001501_abnormal_sleep_pattern	1.12737037
59	MP0003806_abnormal_nucleotide_metabolis	1.11434711
60	MP0005377_hearing/vestibular/ear_phenot	1.10494234
61	MP0003878_abnormal_ear_physiology	1.10494234
62	MP0002272_abnormal_nervous_system	1.10352908
63	MP0002736_abnormal_nociception_after	1.07694700
64	MP0006276_abnormal_autonomic_nervous	1.03433945
65	MP0003011_delayed_dark_adaptation	1.01199550
66	MP0001845_abnormal_inflammatory_respons	0.99707036
67	MP0009745_abnormal_behavioral_response	0.98418036
68	MP0002277_abnormal_respiratory_mucosa	0.98028291
69	MP0003436_decreased_susceptibility_to	0.97398151
70	MP0010155_abnormal_intestine_physiology	0.97005589
71	MP0005389_reproductive_system_phenotype	0.96200503
72	MP0001905_abnormal_dopamine_level	0.94600044
73	MP0000427_abnormal_hair_cycle	0.94422715
74	MP0006036_abnormal_mitochondrial_physio	0.93832887
75	MP0003763_abnormal_thymus_physiology	0.92402424
76	MP0002419_abnormal_innate_immunity	0.91924362
77	MP0001486_abnormal_startle_reflex	0.91904854
78	MP0000716_abnormal_immune_system	0.91397821
79	MP0001970_abnormal_pain_threshold	0.90764223
80	MP0002095_abnormal_skin_pigmentation	0.88817465
81	MP0001765_abnormal_ion_homeostasis	0.88679521
82	MP0008789_abnormal_olfactory_epithelium	0.88579515
83	MP0009046_muscle_twitch	0.87436686
84	MP0000465_gastrointestinal_hemorrhage	0.87004926
85	MP0000569_abnormal_digit_pigmentation	0.85930731
86	MP0005636_abnormal_mineral_homeostasis	0.85769608
87	MP0003638_abnormal_response/metabolism_	0.85524442
88	MP0002933_joint_inflammation	0.85385865
89	MP0002009_preneoplasia	0.84486383
90	MP0001348_abnormal_lacrimal_gland	0.84423687
91	MP0003252_abnormal_bile_duct	0.84100366
92	MP0002398_abnormal_bone_marrow	0.83840352
93	MP0003786_premature_aging	0.83631148
94	MP0000383_abnormal_hair_follicle	0.83255590
95	MP0005410_abnormal_fertilization	0.82307241
96	MP0002938_white_spotting	0.81312596
97	MP0001440_abnormal_grooming_behavior	0.79714267
98	MP0001873_stomach_inflammation	0.77901880
99	MP0003122_maternal_imprinting	0.76452227
100	MP0010386_abnormal_urinary_bladder	0.74640301

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.55605991
2	3-Methylglutaconic aciduria (HP:0003535)	4.23721852
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.15002009
4	Stomatitis (HP:0010280)	4.07420481
5	Mitochondrial inheritance (HP:0001427)	4.05189650
6	Congenital, generalized hypertrichosis (HP:0004540)	3.98429427
7	IgG deficiency (HP:0004315)	3.88706413
8	Acute encephalopathy (HP:0006846)	3.85904183
9	Progressive macrocephaly (HP:0004481)	3.82506541
10	Hepatocellular necrosis (HP:0001404)	3.80639476
11	Increased CSF lactate (HP:0002490)	3.58888772
12	Elevated erythrocyte sedimentation rate (HP:0003565)	3.11792089
13	Hepatic necrosis (HP:0002605)	3.09906004
14	Abnormality of midbrain morphology (HP:0002418)	3.09265897
15	Molar tooth sign on MRI (HP:0002419)	3.09265897
16	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.06735911
17	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.06735911
18	Pancreatic cysts (HP:0001737)	2.96869150
19	Congenital stationary night blindness (HP:0007642)	2.93585165
20	Optic disc pallor (HP:0000543)	2.86948887
21	True hermaphroditism (HP:0010459)	2.85399216
22	Hypoproteinemia (HP:0003075)	2.75680630
23	Nephronophthisis (HP:0000090)	2.70338718
24	Abnormality of the renal cortex (HP:0011035)	2.69681684
25	Severe combined immunodeficiency (HP:0004430)	2.69044478
26	Cerebral edema (HP:0002181)	2.68250218
27	Abolished electroretinogram (ERG) (HP:0000550)	2.62289787
28	Pancreatic fibrosis (HP:0100732)	2.60140762
29	Abnormality of the renal medulla (HP:0100957)	2.42323769
30	Increased hepatocellular lipid droplets (HP:0006565)	2.40568235
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.40079577
32	Leukodystrophy (HP:0002415)	2.39285725
33	Increased intramyocellular lipid droplets (HP:0012240)	2.39188916
34	Hypothermia (HP:0002045)	2.36008215
35	Lipid accumulation in hepatocytes (HP:0006561)	2.35082606
36	Abnormality of cells of the erythroid lineage (HP:0012130)	2.32441679
37	Increased serum lactate (HP:0002151)	2.31785134
38	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.29075389
39	Abnormality of alanine metabolism (HP:0010916)	2.29075389
40	Hyperalaninemia (HP:0003348)	2.29075389
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.29015942
42	Polydipsia (HP:0001959)	2.26046702
43	Abnormal drinking behavior (HP:0030082)	2.26046702
44	Increased IgM level (HP:0003496)	2.21354793
45	Lactic acidosis (HP:0003128)	2.19881048
46	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.17378994
47	Absent/shortened dynein arms (HP:0200106)	2.17378994
48	Abnormality of T cells (HP:0002843)	2.14271995
49	Medial flaring of the eyebrow (HP:0010747)	2.12089006
50	Hypoplasia of the uterus (HP:0000013)	2.11811029
51	Alveolar cell carcinoma (HP:0006519)	2.10622996
52	Reticulocytopenia (HP:0001896)	2.10556690
53	Aplasia/hypoplasia of the uterus (HP:0008684)	2.08353551
54	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.08106574
55	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.07557515
56	Exertional dyspnea (HP:0002875)	2.06921056
57	Type II lissencephaly (HP:0007260)	2.06673667
58	Respiratory failure (HP:0002878)	2.06528708
59	Attenuation of retinal blood vessels (HP:0007843)	2.05986112
60	Polyuria (HP:0000103)	2.05144842
61	Thyroiditis (HP:0100646)	2.04305962
62	Abnormality of T cell number (HP:0011839)	2.01807041
63	Abnormality of the prostate (HP:0008775)	2.01312756
64	T lymphocytopenia (HP:0005403)	2.00574208
65	Male pseudohermaphroditism (HP:0000037)	2.00135902
66	Increased muscle lipid content (HP:0009058)	1.99990664
67	Abnormal number of erythroid precursors (HP:0012131)	1.98208264
68	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.98156454
69	Methylmalonic acidemia (HP:0002912)	1.96192939
70	Renal cortical cysts (HP:0000803)	1.95071279
71	Sclerocornea (HP:0000647)	1.92001657
72	Abnormal respiratory motile cilium physiology (HP:0012261)	1.91915887
73	Combined immunodeficiency (HP:0005387)	1.91359207
74	Abnormal albumin level (HP:0012116)	1.91176458
75	Hypoalbuminemia (HP:0003073)	1.91176458
76	Pendular nystagmus (HP:0012043)	1.90900491
77	Decreased central vision (HP:0007663)	1.88072288
78	Macrocytic anemia (HP:0001972)	1.87129535
79	Pustule (HP:0200039)	1.87047398
80	Lethargy (HP:0001254)	1.86724551
81	Aplastic anemia (HP:0001915)	1.86654998
82	Abnormality of eosinophils (HP:0001879)	1.86300579
83	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.86175967
84	Abnormal ciliary motility (HP:0012262)	1.85703730
85	Bile duct proliferation (HP:0001408)	1.85406187
86	Abnormal biliary tract physiology (HP:0012439)	1.85406187
87	Type I transferrin isoform profile (HP:0003642)	1.84084323
88	Hypoplasia of the ulna (HP:0003022)	1.84077217
89	Short tibia (HP:0005736)	1.82564374
90	Tubular atrophy (HP:0000092)	1.82526184
91	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.80456987
92	B lymphocytopenia (HP:0010976)	1.80132062
93	Type 2 muscle fiber atrophy (HP:0003554)	1.78314282
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.77610586
95	Abnormality of T cell physiology (HP:0011840)	1.76405120
96	Hypomagnesemia (HP:0002917)	1.75023881
97	Constricted visual fields (HP:0001133)	1.73643683
98	Woolly hair (HP:0002224)	1.73033908
99	Conical tooth (HP:0000698)	1.71723451
100	Pallor (HP:0000980)	1.70893277

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.41724205
2	TXK	4.37642055
3	MAP3K12	3.21701253
4	NUAK1	3.04197668
5	MAP4K2	3.01356267
6	CDK19	2.45379196
7	BMPR2	2.36783157
8	TLK1	2.25841373
9	ADRBK2	2.19076351
10	ZAK	2.09366905
11	FRK	2.00191175
12	STK16	1.99194500
13	GRK1	1.98026421
14	MYLK	1.93341230
15	WNK3	1.80259213
16	PINK1	1.67605287
17	WNK4	1.66871130
18	FES	1.56254034
19	IKBKB	1.51120085
20	GRK6	1.50363827
21	GRK7	1.49544054
22	ERBB3	1.45031400
23	MAP4K1	1.34317516
24	OXSR1	1.29666479
25	KIT	1.24006016
26	KDR	1.21375173
27	GRK5	1.20701736
28	BCKDK	1.15609445
29	ILK	1.10819872
30	MAP2K2	1.09744564
31	TEC	1.09234094
32	DAPK1	1.07970531
33	MST4	1.07289405
34	CSF1R	1.06069735
35	PIK3CG	1.05231880
36	IKBKE	1.05126111
37	BMPR1B	1.02515370
38	SYK	1.01586539
39	EPHA4	1.01527651
40	INSRR	0.95903176
41	ITK	0.94695462
42	SCYL2	0.87081249
43	TIE1	0.86825805
44	LYN	0.85892684
45	DYRK2	0.80287798
46	DAPK3	0.78589871
47	MAPK13	0.78183806
48	DAPK2	0.77076678
49	PRKCE	0.74859847
50	ADRBK1	0.74558810
51	TRPM7	0.74303558
52	VRK1	0.74194533
53	LIMK1	0.73849842
54	FLT3	0.71861773
55	MUSK	0.70440435
56	OBSCN	0.70233136
57	ZAP70	0.69048099
58	LCK	0.68995531
59	TRIM28	0.68765093
60	PIK3CA	0.68301654
61	BTK	0.67187205
62	CAMKK2	0.66417146
63	MAP3K14	0.64208204
64	PHKG1	0.61783937
65	PHKG2	0.61783937
66	JAK1	0.61368830
67	VRK2	0.61130999
68	RPS6KA5	0.60547096
69	MARK3	0.57619140
70	PRKCQ	0.56898522
71	IGF1R	0.56878486
72	EIF2AK2	0.56337214
73	PIM1	0.55366763
74	TBK1	0.53706993
75	PRKACA	0.46708330
76	ABL1	0.46644986
77	STK39	0.44849821
78	ROCK1	0.43760112
79	PRKG1	0.43091478
80	RPS6KA4	0.41483759
81	JAK3	0.40731049
82	MAP2K7	0.40317904
83	PRKCA	0.40105649
84	STK38L	0.37485684
85	CAMK2A	0.36500682
86	ACVR1B	0.34102799
87	HCK	0.33908556
88	PRKCD	0.33205142
89	CHUK	0.33104728
90	PRKCG	0.32556204
91	CAMK2D	0.32172992
92	MAP2K6	0.31683988
93	PRKACG	0.31367600
94	PTK2B	0.30999335
95	AURKB	0.30562624
96	EGFR	0.30383003
97	CAMK1	0.29321068
98	ATR	0.28712928
99	EPHA3	0.28355886
100	CSNK1A1	0.27758879

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.20088629
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.65170400
3	Allograft rejection_Homo sapiens_hsa05330	3.52288001
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.43700560
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.38691989
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.36197152
7	Ribosome_Homo sapiens_hsa03010	3.11051456
8	Parkinsons disease_Homo sapiens_hsa05012	2.88353610
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.82851254
10	Protein export_Homo sapiens_hsa03060	2.50758155
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.47082768
12	Proteasome_Homo sapiens_hsa03050	2.42984351
13	Alzheimers disease_Homo sapiens_hsa05010	2.07135800
14	Primary immunodeficiency_Homo sapiens_hsa05340	2.06120696
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.00176658
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.96142409
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.83502437
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.81875209
19	Huntingtons disease_Homo sapiens_hsa05016	1.80139456
20	RNA polymerase_Homo sapiens_hsa03020	1.73441520
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.66261519
22	Phototransduction_Homo sapiens_hsa04744	1.51556754
23	Viral myocarditis_Homo sapiens_hsa05416	1.45118900
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.37040385
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29628661
26	RNA degradation_Homo sapiens_hsa03018	1.26856800
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.26787834
28	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.22288901
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.07050132
30	Homologous recombination_Homo sapiens_hsa03440	1.03111929
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98422791
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.98332457
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94290689
34	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.89114178
35	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88442001
36	Leishmaniasis_Homo sapiens_hsa05140	0.87772526
37	Tryptophan metabolism_Homo sapiens_hsa00380	0.87494558
38	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.87354094
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86026245
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.82106801
41	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.81586020
42	Olfactory transduction_Homo sapiens_hsa04740	0.80844482
43	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.78811992
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.77659402
45	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.76433134
46	One carbon pool by folate_Homo sapiens_hsa00670	0.75828098
47	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74981654
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73692634
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72900516
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72387686
51	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.71779122
52	Peroxisome_Homo sapiens_hsa04146	0.71166759
53	Nicotine addiction_Homo sapiens_hsa05033	0.69391545
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66149026
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65811042
56	Caffeine metabolism_Homo sapiens_hsa00232	0.64727833
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.64529485
58	Retinol metabolism_Homo sapiens_hsa00830	0.62214579
59	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.61097840
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.60894626
61	Butanoate metabolism_Homo sapiens_hsa00650	0.59911340
62	Sulfur metabolism_Homo sapiens_hsa00920	0.59728870
63	Propanoate metabolism_Homo sapiens_hsa00640	0.59449045
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59350387
65	Basal transcription factors_Homo sapiens_hsa03022	0.57924119
66	Purine metabolism_Homo sapiens_hsa00230	0.54137283
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.52046337
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51438416
69	Regulation of autophagy_Homo sapiens_hsa04140	0.51198919
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.50459090
71	Morphine addiction_Homo sapiens_hsa05032	0.49226436
72	Salivary secretion_Homo sapiens_hsa04970	0.48877125
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.47955171
74	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.47430823
75	Herpes simplex infection_Homo sapiens_hsa05168	0.46582959
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45766260
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45140724
78	Taste transduction_Homo sapiens_hsa04742	0.43310741
79	Spliceosome_Homo sapiens_hsa03040	0.42841572
80	Metabolic pathways_Homo sapiens_hsa01100	0.40573527
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37788544
82	GABAergic synapse_Homo sapiens_hsa04727	0.35806139
83	Mismatch repair_Homo sapiens_hsa03430	0.35805827
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32869972
85	Toxoplasmosis_Homo sapiens_hsa05145	0.30032796
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28516138
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.27092047
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.26979781
89	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.26489490
90	Tuberculosis_Homo sapiens_hsa05152	0.24279970
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.22229005
92	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.22207797
93	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.20985204
94	RNA transport_Homo sapiens_hsa03013	0.20453720
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.19783574
96	African trypanosomiasis_Homo sapiens_hsa05143	0.18394051
97	Glutathione metabolism_Homo sapiens_hsa00480	0.18321655
98	Measles_Homo sapiens_hsa05162	0.18216388
99	Nucleotide excision repair_Homo sapiens_hsa03420	0.17962001
100	Folate biosynthesis_Homo sapiens_hsa00790	0.17350520

RPL21P71

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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