ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.94067557
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.75808484
3	ATP synthesis coupled proton transport (GO:0015986)	5.75808484
4	ribosomal small subunit assembly (GO:0000028)	5.47264940
5	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.06246926
6	viral transcription (GO:0019083)	4.82048860
7	DNA deamination (GO:0045006)	4.79958696
8	translational termination (GO:0006415)	4.70255863
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.65969958
10	respiratory electron transport chain (GO:0022904)	4.58104913
11	cotranslational protein targeting to membrane (GO:0006613)	4.56219801
12	electron transport chain (GO:0022900)	4.52887332
13	protein targeting to ER (GO:0045047)	4.50890052
14	protein localization to endoplasmic reticulum (GO:0070972)	4.32647457
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.29946302
16	proteasome assembly (GO:0043248)	4.25825401
17	protein complex biogenesis (GO:0070271)	4.17968850
18	ribosomal large subunit biogenesis (GO:0042273)	4.12561076
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.11801738
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.11801738
21	NADH dehydrogenase complex assembly (GO:0010257)	4.11801738
22	translational elongation (GO:0006414)	4.09450048
23	maturation of SSU-rRNA (GO:0030490)	4.01223863
24	protein neddylation (GO:0045116)	3.95569176
25	mitochondrial respiratory chain complex assembly (GO:0033108)	3.79183337
26	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.74819669
27	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.74819669
28	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.65597295
29	translation (GO:0006412)	3.52788249
30	platelet dense granule organization (GO:0060155)	3.52220111
31	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.50548663
32	translational initiation (GO:0006413)	3.46541150
33	cellular protein complex disassembly (GO:0043624)	3.46258755
34	viral life cycle (GO:0019058)	3.44905741
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.37422181
36	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.33919114
37	GPI anchor biosynthetic process (GO:0006506)	3.24320873
38	hydrogen ion transmembrane transport (GO:1902600)	3.23187365
39	kynurenine metabolic process (GO:0070189)	3.21309759
40	termination of RNA polymerase III transcription (GO:0006386)	3.18983659
41	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.18983659
42	respiratory chain complex IV assembly (GO:0008535)	3.16712049
43	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.16301709
44	GPI anchor metabolic process (GO:0006505)	3.13337940
45	tryptophan catabolic process (GO:0006569)	3.12893126
46	indole-containing compound catabolic process (GO:0042436)	3.12893126
47	indolalkylamine catabolic process (GO:0046218)	3.12893126
48	chaperone-mediated protein transport (GO:0072321)	3.11121169
49	proton transport (GO:0015992)	3.10817747
50	ATP biosynthetic process (GO:0006754)	3.09541714
51	hydrogen transport (GO:0006818)	3.07896350
52	indolalkylamine metabolic process (GO:0006586)	3.02911168
53	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.02458821
54	protein targeting to membrane (GO:0006612)	3.01111382
55	ribosomal small subunit biogenesis (GO:0042274)	2.98231953
56	regulation of cellular respiration (GO:0043457)	2.97685929
57	deoxyribose phosphate catabolic process (GO:0046386)	2.97001207
58	cytidine metabolic process (GO:0046087)	2.91801881
59	cytidine catabolic process (GO:0006216)	2.91801881
60	cytidine deamination (GO:0009972)	2.91801881
61	aldehyde catabolic process (GO:0046185)	2.90882319
62	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.90506177
63	cytochrome complex assembly (GO:0017004)	2.88774914
64	regulation of cellular amino acid metabolic process (GO:0006521)	2.88600856
65	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.87834101
66	deoxyribonucleotide catabolic process (GO:0009264)	2.87694472
67	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.86897509
68	oxidative phosphorylation (GO:0006119)	2.86288033
69	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.85520735
70	regulation of hypersensitivity (GO:0002883)	2.84919225
71	protein complex disassembly (GO:0043241)	2.80914610
72	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.80479301
73	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.80479301
74	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.80479301
75	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.79633933
76	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.78242316
77	base-excision repair, AP site formation (GO:0006285)	2.77677520
78	tryptophan metabolic process (GO:0006568)	2.77477544
79	mast cell activation (GO:0045576)	2.77370187
80	macromolecular complex disassembly (GO:0032984)	2.76903539
81	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.76473968
82	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.76473968
83	purine deoxyribonucleotide catabolic process (GO:0009155)	2.75996034
84	water-soluble vitamin biosynthetic process (GO:0042364)	2.75695543
85	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.74813333
86	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.74541927
87	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.72617949
88	protein-cofactor linkage (GO:0018065)	2.70714177
89	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.68767186
90	preassembly of GPI anchor in ER membrane (GO:0016254)	2.67861501
91	organelle disassembly (GO:1903008)	2.64873155
92	cellular component biogenesis (GO:0044085)	2.64755369
93	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.63574443
94	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.62978859
95	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.62978859
96	negative regulation of heart rate (GO:0010459)	2.58877435
97	actin nucleation (GO:0045010)	2.58855124
98	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.57135503
99	immunoglobulin mediated immune response (GO:0016064)	2.56912974
100	mRNA catabolic process (GO:0006402)	2.56619713

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.07088633
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.95557576
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.77208985
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.44215617
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86446724
6	VDR_22108803_ChIP-Seq_LS180_Human	2.85021563
7	VDR_23849224_ChIP-Seq_CD4+_Human	2.68168254
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.63373149
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58034651
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.49798849
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.43564483
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.40284310
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.39865977
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.35043023
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.34444595
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.22612117
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.18121789
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.15366818
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.09308144
20	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.02840856
21	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.99618814
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.87246508
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.84296321
24	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.82122390
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.81361433
26	EWS_26573619_Chip-Seq_HEK293_Human	1.81013938
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80371069
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.79993043
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.73563144
30	FUS_26573619_Chip-Seq_HEK293_Human	1.73053077
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.66508366
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.63730825
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58976024
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.57553708
35	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.55557662
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.52995854
37	EZH2_22144423_ChIP-Seq_EOC_Human	1.50540165
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49139239
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.43176986
40	AR_20517297_ChIP-Seq_VCAP_Human	1.42935164
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.35424203
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35309146
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35309146
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33022796
45	P300_19829295_ChIP-Seq_ESCs_Human	1.31659478
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31291723
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.31291723
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31088609
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31088609
50	TTF2_22483619_ChIP-Seq_HELA_Human	1.30638328
51	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.30165040
52	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.28468790
53	GATA3_26560356_Chip-Seq_TH2_Human	1.28326200
54	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.27490328
55	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.26025528
56	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.25673993
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.23384152
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22482369
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.21811640
60	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.21606997
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20211764
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16811620
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16681612
64	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.16486238
65	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.15691539
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15001806
67	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14922467
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14334105
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14125940
70	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13035308
71	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12787832
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12600635
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09877004
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09653325
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09607051
76	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09310454
77	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08082817
78	DCP1A_22483619_ChIP-Seq_HELA_Human	1.07712640
79	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.07682805
80	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06958653
81	NCOR_22424771_ChIP-Seq_293T_Human	1.06808868
82	ERG_20517297_ChIP-Seq_VCAP_Human	1.06580097
83	MYB_26560356_Chip-Seq_TH2_Human	1.03455879
84	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.02945943
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00925402
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00607762
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00506305
88	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.00429797
89	GABP_19822575_ChIP-Seq_HepG2_Human	0.99732806
90	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99094608
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98162363
92	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97845845
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97704597
94	GBX2_23144817_ChIP-Seq_PC3_Human	0.95805704
95	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.93918878
96	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93525445
97	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91841090
98	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91567523
99	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.89942879
100	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.89114682

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.43575205
2	MP0001835_abnormal_antigen_presentation	3.65145465
3	MP0003806_abnormal_nucleotide_metabolis	3.58809243
4	MP0005671_abnormal_response_to	3.05787913
5	MP0006072_abnormal_retinal_apoptosis	2.86198280
6	MP0006292_abnormal_olfactory_placode	2.51545398
7	MP0002163_abnormal_gland_morphology	2.14710180
8	MP0003646_muscle_fatigue	2.10181129
9	MP0005646_abnormal_pituitary_gland	2.00316078
10	MP0002837_dystrophic_cardiac_calcinosis	1.98680951
11	MP0008872_abnormal_physiological_respon	1.97008319
12	MP0004142_abnormal_muscle_tone	1.96835401
13	MP0008875_abnormal_xenobiotic_pharmacok	1.91980006
14	MP0004147_increased_porphyrin_level	1.91481984
15	MP0008877_abnormal_DNA_methylation	1.87870376
16	MP0002166_altered_tumor_susceptibility	1.87244485
17	MP0005075_abnormal_melanosome_morpholog	1.87240167
18	MP0000372_irregular_coat_pigmentation	1.78901407
19	MP0005645_abnormal_hypothalamus_physiol	1.77388582
20	MP0002102_abnormal_ear_morphology	1.73092482
21	MP0004145_abnormal_muscle_electrophysio	1.71430666
22	MP0005367_renal/urinary_system_phenotyp	1.69540290
23	MP0000516_abnormal_urinary_system	1.69540290
24	MP0003195_calcinosis	1.68045076
25	MP0001529_abnormal_vocalization	1.67967406
26	MP0009785_altered_susceptibility_to	1.63122929
27	MP0005253_abnormal_eye_physiology	1.61130833
28	MP0006036_abnormal_mitochondrial_physio	1.60640166
29	MP0009764_decreased_sensitivity_to	1.59455432
30	MP0002148_abnormal_hypersensitivity_rea	1.58421708
31	MP0005551_abnormal_eye_electrophysiolog	1.57353389
32	MP0002006_tumorigenesis	1.56583131
33	MP0002876_abnormal_thyroid_physiology	1.55792315
34	MP0001800_abnormal_humoral_immune	1.54177895
35	MP0008995_early_reproductive_senescence	1.51446856
36	MP0003880_abnormal_central_pattern	1.51185790
37	MP0001968_abnormal_touch/_nociception	1.47059317
38	MP0003186_abnormal_redox_activity	1.43301693
39	MP0001905_abnormal_dopamine_level	1.42839145
40	MP0005084_abnormal_gallbladder_morpholo	1.40351475
41	MP0005379_endocrine/exocrine_gland_phen	1.39693341
42	MP0003787_abnormal_imprinting	1.36187002
43	MP0008789_abnormal_olfactory_epithelium	1.32125072
44	MP0003011_delayed_dark_adaptation	1.30378165
45	MP0006276_abnormal_autonomic_nervous	1.29090897
46	MP0001919_abnormal_reproductive_system	1.28772344
47	MP0002234_abnormal_pharynx_morphology	1.27644296
48	MP0005389_reproductive_system_phenotype	1.25533718
49	MP0002736_abnormal_nociception_after	1.22698581
50	MP0003786_premature_aging	1.22688220
51	MP0008058_abnormal_DNA_repair	1.22662497
52	MP0005000_abnormal_immune_tolerance	1.22643752
53	MP0002095_abnormal_skin_pigmentation	1.21262472
54	MP0001984_abnormal_olfaction	1.18720367
55	MP0002723_abnormal_immune_serum	1.17955225
56	MP0002452_abnormal_antigen_presenting	1.17058543
57	MP0001986_abnormal_taste_sensitivity	1.15936586
58	MP0003252_abnormal_bile_duct	1.12796657
59	MP0001819_abnormal_immune_cell	1.03127793
60	MP0009046_muscle_twitch	1.02920308
61	MP0002272_abnormal_nervous_system	1.02509102
62	MP0005636_abnormal_mineral_homeostasis	1.02292998
63	MP0002420_abnormal_adaptive_immunity	1.02264090
64	MP0009333_abnormal_splenocyte_physiolog	1.00190581
65	MP0002090_abnormal_vision	0.98523417
66	MP0005410_abnormal_fertilization	0.97370765
67	MP0002160_abnormal_reproductive_system	0.93695590
68	MP0004885_abnormal_endolymph	0.93285831
69	MP0000685_abnormal_immune_system	0.92321447
70	MP0003866_abnormal_defecation	0.91402566
71	MP0003724_increased_susceptibility_to	0.91287990
72	MP0001764_abnormal_homeostasis	0.90681703
73	MP0005387_immune_system_phenotype	0.90250407
74	MP0001790_abnormal_immune_system	0.90250407
75	MP0010386_abnormal_urinary_bladder	0.89222398
76	MP0009745_abnormal_behavioral_response	0.88301391
77	MP0001970_abnormal_pain_threshold	0.87269930
78	MP0005025_abnormal_response_to	0.84668667
79	MP0005174_abnormal_tail_pigmentation	0.84295221
80	MP0001486_abnormal_startle_reflex	0.84276800
81	MP0006082_CNS_inflammation	0.83480893
82	MP0000631_abnormal_neuroendocrine_gland	0.82681106
83	MP0000569_abnormal_digit_pigmentation	0.81193778
84	MP0001765_abnormal_ion_homeostasis	0.80567491
85	MP0002638_abnormal_pupillary_reflex	0.78876688
86	MP0009697_abnormal_copulation	0.77837298
87	MP0000716_abnormal_immune_system	0.77577473
88	MP0001845_abnormal_inflammatory_respons	0.76456710
89	MP0005332_abnormal_amino_acid	0.76194582
90	MP0005085_abnormal_gallbladder_physiolo	0.75872869
91	MP0003718_maternal_effect	0.73970869
92	MP0002138_abnormal_hepatobiliary_system	0.73969873
93	MP0010155_abnormal_intestine_physiology	0.73950099
94	MP0005499_abnormal_olfactory_system	0.73055622
95	MP0005394_taste/olfaction_phenotype	0.73055622
96	MP0002398_abnormal_bone_marrow	0.72741857
97	MP0002751_abnormal_autonomic_nervous	0.71379473
98	MP0001485_abnormal_pinna_reflex	0.71011268
99	MP0003763_abnormal_thymus_physiology	0.70547858
100	MP0005195_abnormal_posterior_eye	0.69206522

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.28376044
2	Mitochondrial inheritance (HP:0001427)	4.80570269
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.69953029
4	Hepatocellular necrosis (HP:0001404)	4.66684158
5	Progressive macrocephaly (HP:0004481)	4.52788583
6	Acute encephalopathy (HP:0006846)	4.38579606
7	Increased CSF lactate (HP:0002490)	4.24710668
8	3-Methylglutaconic aciduria (HP:0003535)	4.11218364
9	Hepatic necrosis (HP:0002605)	4.02434692
10	Congenital, generalized hypertrichosis (HP:0004540)	3.46498779
11	Increased hepatocellular lipid droplets (HP:0006565)	3.42079717
12	Cerebral edema (HP:0002181)	3.32352091
13	Lipid accumulation in hepatocytes (HP:0006561)	3.30497010
14	Aplastic anemia (HP:0001915)	3.14035018
15	Hypoproteinemia (HP:0003075)	3.06417443
16	Pancreatic cysts (HP:0001737)	3.05427303
17	Abolished electroretinogram (ERG) (HP:0000550)	2.93001084
18	Abnormality of midbrain morphology (HP:0002418)	2.92104059
19	Molar tooth sign on MRI (HP:0002419)	2.92104059
20	Optic disc pallor (HP:0000543)	2.88205934
21	Renal Fanconi syndrome (HP:0001994)	2.85597792
22	Exertional dyspnea (HP:0002875)	2.81846558
23	IgG deficiency (HP:0004315)	2.80178460
24	Increased serum lactate (HP:0002151)	2.79038148
25	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.75119111
26	Increased intramyocellular lipid droplets (HP:0012240)	2.73456178
27	Leukodystrophy (HP:0002415)	2.68599098
28	Lactic acidosis (HP:0003128)	2.68315332
29	Congenital stationary night blindness (HP:0007642)	2.68123852
30	Reticulocytopenia (HP:0001896)	2.66044095
31	Respiratory failure (HP:0002878)	2.63719153
32	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.63578936
33	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.63578936
34	Severe combined immunodeficiency (HP:0004430)	2.58262335
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.46760169
36	Medial flaring of the eyebrow (HP:0010747)	2.45517211
37	Abnormality of cells of the erythroid lineage (HP:0012130)	2.45484558
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.43978247
39	Macrocytic anemia (HP:0001972)	2.43064597
40	Thyroiditis (HP:0100646)	2.38318383
41	Increased muscle lipid content (HP:0009058)	2.35311596
42	Abnormality of the prostate (HP:0008775)	2.34402764
43	Pancreatic fibrosis (HP:0100732)	2.34197057
44	True hermaphroditism (HP:0010459)	2.31682295
45	Abnormality of B cell number (HP:0010975)	2.31436944
46	Methylmalonic acidemia (HP:0002912)	2.30833984
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.30827732
48	Attenuation of retinal blood vessels (HP:0007843)	2.28897901
49	Nephronophthisis (HP:0000090)	2.22627052
50	Panhypogammaglobulinemia (HP:0003139)	2.15654980
51	Decreased central vision (HP:0007663)	2.15282104
52	B lymphocytopenia (HP:0010976)	2.15261947
53	Lethargy (HP:0001254)	2.13682759
54	Exercise intolerance (HP:0003546)	2.12873826
55	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.11932275
56	CNS demyelination (HP:0007305)	2.11438570
57	Abnormal number of erythroid precursors (HP:0012131)	2.11154768
58	Elevated erythrocyte sedimentation rate (HP:0003565)	2.08907829
59	Type 2 muscle fiber atrophy (HP:0003554)	2.05612882
60	Type II lissencephaly (HP:0007260)	2.03741483
61	Congenital primary aphakia (HP:0007707)	2.02938084
62	Methylmalonic aciduria (HP:0012120)	2.01477121
63	Abnormality of the renal medulla (HP:0100957)	1.97808416
64	Type I transferrin isoform profile (HP:0003642)	1.95668768
65	Abnormality of the renal cortex (HP:0011035)	1.94517297
66	Gait imbalance (HP:0002141)	1.93761979
67	Constricted visual fields (HP:0001133)	1.91793371
68	Increased IgM level (HP:0003496)	1.90500770
69	Abnormality of renal resorption (HP:0011038)	1.90476184
70	Pallor (HP:0000980)	1.88421145
71	Cleft eyelid (HP:0000625)	1.87949788
72	Abnormality of alanine metabolism (HP:0010916)	1.87207399
73	Hyperalaninemia (HP:0003348)	1.87207399
74	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.87207399
75	Hypothermia (HP:0002045)	1.86824008
76	Combined immunodeficiency (HP:0005387)	1.85669996
77	Nephrogenic diabetes insipidus (HP:0009806)	1.83949770
78	Absent thumb (HP:0009777)	1.80278974
79	Delayed CNS myelination (HP:0002188)	1.79919746
80	Reduced antithrombin III activity (HP:0001976)	1.76236124
81	Stomatitis (HP:0010280)	1.74867141
82	Aplasia/hypoplasia of the uterus (HP:0008684)	1.73546636
83	Pancytopenia (HP:0001876)	1.73492912
84	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.72526735
85	Colon cancer (HP:0003003)	1.72006261
86	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.71944492
87	Emotional lability (HP:0000712)	1.71718431
88	Abnormality of eosinophils (HP:0001879)	1.71491581
89	Stenosis of the external auditory canal (HP:0000402)	1.71490643
90	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.70355793
91	Renal cortical cysts (HP:0000803)	1.69447112
92	Porencephaly (HP:0002132)	1.69401262
93	Abnormal protein glycosylation (HP:0012346)	1.68823866
94	Abnormal glycosylation (HP:0012345)	1.68823866
95	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.68823866
96	Abnormal protein N-linked glycosylation (HP:0012347)	1.68823866
97	Abnormal drinking behavior (HP:0030082)	1.68055346
98	Polydipsia (HP:0001959)	1.68055346
99	X-linked dominant inheritance (HP:0001423)	1.67549341
100	Eosinophilia (HP:0001880)	1.66174093

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.01073497
2	CDK19	3.56798920
3	MAP3K12	3.54998822
4	ZAK	2.68493839
5	TXK	2.55331562
6	BMPR2	2.54361758
7	TLK1	2.50535192
8	NUAK1	2.45029816
9	FRK	2.38853445
10	STK16	2.32921655
11	TAOK3	2.09471301
12	MYLK	1.96318824
13	ADRBK2	1.89317025
14	KDR	1.87594655
15	BCKDK	1.83400870
16	SCYL2	1.79544653
17	VRK2	1.79433223
18	ERBB3	1.68219210
19	GRK1	1.61344266
20	PINK1	1.56179054
21	OXSR1	1.55556163
22	TEC	1.54106086
23	TRIM28	1.46029564
24	EIF2AK3	1.40792223
25	WNK3	1.32784812
26	ITK	1.23592804
27	TIE1	1.20146904
28	SRPK1	1.18344017
29	MST4	1.17769428
30	KIT	1.16905028
31	VRK1	1.14407711
32	CSNK1G3	1.14058099
33	CSF1R	1.13849187
34	WNK4	1.08113878
35	FLT3	1.07675458
36	RPS6KA4	1.07187252
37	DAPK1	1.05187320
38	MAP4K1	1.03926552
39	MAP2K7	1.03153238
40	INSRR	1.02401664
41	IKBKB	1.01850406
42	ILK	1.01696998
43	MAP3K4	0.99511295
44	CSNK1G2	0.99476946
45	NEK1	0.96906229
46	GRK6	0.96461551
47	PASK	0.92218928
48	DYRK2	0.90842408
49	DAPK3	0.88945168
50	CSNK1G1	0.88712445
51	LIMK1	0.87186126
52	CSNK1A1L	0.86826798
53	MUSK	0.86715167
54	BTK	0.86502153
55	LYN	0.86151273
56	TESK2	0.85455719
57	RPS6KA5	0.84387071
58	BMPR1B	0.83097713
59	PIK3CG	0.82325359
60	BCR	0.81855539
61	SYK	0.78209748
62	FES	0.68184771
63	MKNK1	0.67998252
64	OBSCN	0.67096038
65	MAPK13	0.65994519
66	TNK2	0.65816235
67	STK39	0.63911784
68	ATR	0.63412979
69	PLK4	0.62118242
70	CAMKK2	0.60505760
71	LCK	0.59305082
72	PRKCE	0.57928647
73	AURKB	0.56308180
74	PRKCQ	0.52373362
75	CSNK2A2	0.49869070
76	GRK7	0.46660579
77	PLK2	0.46365583
78	IKBKE	0.45439139
79	IGF1R	0.44810977
80	PRKACA	0.44225801
81	CSNK2A1	0.43958230
82	CCNB1	0.42926823
83	ADRBK1	0.42123760
84	CDK3	0.41390346
85	CDC7	0.40205112
86	PLK3	0.38280984
87	CSNK1A1	0.37631513
88	PRKCA	0.36269766
89	NME2	0.35617771
90	ABL1	0.34878074
91	GRK5	0.34242432
92	TRPM7	0.33676206
93	MATK	0.33270374
94	CAMK2A	0.32419530
95	RIPK4	0.31407673
96	PIM1	0.29855744
97	MAPKAPK5	0.29708846
98	MAP2K6	0.29353387
99	EIF2AK2	0.29246495
100	ROCK1	0.28986824

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.08828916
2	Ribosome_Homo sapiens_hsa03010	3.92584829
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.87584374
4	Protein export_Homo sapiens_hsa03060	3.36856296
5	Allograft rejection_Homo sapiens_hsa05330	3.22762034
6	Proteasome_Homo sapiens_hsa03050	3.19267796
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.11304773
8	Parkinsons disease_Homo sapiens_hsa05012	3.10837159
9	Graft-versus-host disease_Homo sapiens_hsa05332	3.01027389
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.95251008
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.69183140
12	Alzheimers disease_Homo sapiens_hsa05010	2.09550212
13	Huntingtons disease_Homo sapiens_hsa05016	2.07091613
14	RNA polymerase_Homo sapiens_hsa03020	2.05719653
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.89188257
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.84513323
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.70129013
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.68834220
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.64964199
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.63862499
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.58868248
22	Homologous recombination_Homo sapiens_hsa03440	1.49518680
23	Viral myocarditis_Homo sapiens_hsa05416	1.40944771
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.34726064
25	RNA degradation_Homo sapiens_hsa03018	1.32691730
26	Phototransduction_Homo sapiens_hsa04744	1.22449288
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.16066244
28	One carbon pool by folate_Homo sapiens_hsa00670	1.14751582
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12040058
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11720226
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02294345
32	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.97360019
33	Propanoate metabolism_Homo sapiens_hsa00640	0.95031526
34	DNA replication_Homo sapiens_hsa03030	0.94925842
35	Pyrimidine metabolism_Homo sapiens_hsa00240	0.94803581
36	Tryptophan metabolism_Homo sapiens_hsa00380	0.91430167
37	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.90719301
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.90563466
39	Spliceosome_Homo sapiens_hsa03040	0.90094674
40	Regulation of autophagy_Homo sapiens_hsa04140	0.88601207
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.85858063
42	Non-homologous end-joining_Homo sapiens_hsa03450	0.84800665
43	Mismatch repair_Homo sapiens_hsa03430	0.84318978
44	Collecting duct acid secretion_Homo sapiens_hsa04966	0.83962648
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.82033389
46	Basal transcription factors_Homo sapiens_hsa03022	0.80092325
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.75966092
48	Caffeine metabolism_Homo sapiens_hsa00232	0.75906549
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75770060
50	Leishmaniasis_Homo sapiens_hsa05140	0.75478312
51	RNA transport_Homo sapiens_hsa03013	0.73905745
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73368776
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.73186900
54	Purine metabolism_Homo sapiens_hsa00230	0.72553927
55	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.72284250
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71812920
57	Base excision repair_Homo sapiens_hsa03410	0.71706197
58	Olfactory transduction_Homo sapiens_hsa04740	0.68779792
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.68254282
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.67711539
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67378561
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.66068761
63	Peroxisome_Homo sapiens_hsa04146	0.63007132
64	Butanoate metabolism_Homo sapiens_hsa00650	0.62055318
65	Fatty acid elongation_Homo sapiens_hsa00062	0.61707325
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61609143
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.61574384
68	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.59229581
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.54615704
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54039276
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.50085850
72	Metabolic pathways_Homo sapiens_hsa01100	0.49529164
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.48313346
74	Nicotine addiction_Homo sapiens_hsa05033	0.43966701
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.43273125
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42000657
77	Retinol metabolism_Homo sapiens_hsa00830	0.41257185
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39453212
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.39035655
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38506382
81	Herpes simplex infection_Homo sapiens_hsa05168	0.38365337
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36800542
83	Glutathione metabolism_Homo sapiens_hsa00480	0.36341858
84	Taste transduction_Homo sapiens_hsa04742	0.35798313
85	Sulfur metabolism_Homo sapiens_hsa00920	0.34712672
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34451141
87	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.30853813
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30852847
89	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.28837697
90	Phagosome_Homo sapiens_hsa04145	0.28242964
91	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.26726356
92	Salivary secretion_Homo sapiens_hsa04970	0.24812897
93	Tuberculosis_Homo sapiens_hsa05152	0.24295875
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.22480764
95	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.21353528
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.20459606
97	Morphine addiction_Homo sapiens_hsa05032	0.19509898
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.18393314
99	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.18012834
100	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.17748958

RPL21P75

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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