RPL21P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.68873747
2DNA deamination (GO:0045006)5.44253988
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.44088140
4ATP synthesis coupled proton transport (GO:0015986)5.36716702
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.36716702
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.16503420
7cytidine deamination (GO:0009972)5.16282091
8cytidine metabolic process (GO:0046087)5.16282091
9cytidine catabolic process (GO:0006216)5.16282091
10viral transcription (GO:0019083)4.79685652
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.72235224
12translational termination (GO:0006415)4.60896035
13respiratory electron transport chain (GO:0022904)4.49310493
14pyrimidine ribonucleoside catabolic process (GO:0046133)4.45478095
15electron transport chain (GO:0022900)4.45169567
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.35528119
17cotranslational protein targeting to membrane (GO:0006613)4.30771456
18protein targeting to ER (GO:0045047)4.27885222
19maturation of SSU-rRNA (GO:0030490)4.24433831
20translational elongation (GO:0006414)4.13130032
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.09837502
22protein localization to endoplasmic reticulum (GO:0070972)4.08342251
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.05622089
24protein neddylation (GO:0045116)3.99188565
25protein complex biogenesis (GO:0070271)3.85148204
26behavioral response to nicotine (GO:0035095)3.80854680
27sequestering of actin monomers (GO:0042989)3.77687698
28ribosomal large subunit biogenesis (GO:0042273)3.71129913
29ribosomal small subunit biogenesis (GO:0042274)3.68123637
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65868894
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.65868894
32NADH dehydrogenase complex assembly (GO:0010257)3.65868894
33mitochondrial respiratory chain complex assembly (GO:0033108)3.49091317
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.45161058
35chaperone-mediated protein transport (GO:0072321)3.43659333
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.43035344
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.43035344
38cellular protein complex disassembly (GO:0043624)3.40851002
39viral life cycle (GO:0019058)3.39973463
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26590983
41hydrogen ion transmembrane transport (GO:1902600)3.26301510
42translation (GO:0006412)3.23424009
43translational initiation (GO:0006413)3.20897478
44water-soluble vitamin biosynthetic process (GO:0042364)3.18739038
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14770185
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.11771277
47termination of RNA polymerase III transcription (GO:0006386)3.11771277
48proton transport (GO:0015992)3.10359998
49positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.06469433
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04326213
51regulation of regulatory T cell differentiation (GO:0045589)3.04029641
52hydrogen transport (GO:0006818)3.03946826
53response to pheromone (GO:0019236)3.02723626
54ATP biosynthetic process (GO:0006754)2.91316935
55actin nucleation (GO:0045010)2.90377902
56regulation of isotype switching to IgG isotypes (GO:0048302)2.90188485
57platelet dense granule organization (GO:0060155)2.82502493
58regulation of cellular amino acid metabolic process (GO:0006521)2.79516919
59regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.75946387
60purine nucleoside triphosphate biosynthetic process (GO:0009145)2.75301335
61protein targeting to membrane (GO:0006612)2.74011249
62response to interferon-beta (GO:0035456)2.73961351
63respiratory chain complex IV assembly (GO:0008535)2.73003698
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.72857906
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.68571352
66positive regulation of defense response to virus by host (GO:0002230)2.67706395
67positive T cell selection (GO:0043368)2.67272946
68cytochrome complex assembly (GO:0017004)2.66990848
69protein complex disassembly (GO:0043241)2.66443570
70cellular component biogenesis (GO:0044085)2.66027727
71positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.64905452
72pseudouridine synthesis (GO:0001522)2.61150161
73positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.61032382
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.58017607
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.57525018
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.57525018
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.57525018
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.57231521
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.57231521
80regulation of activation of Janus kinase activity (GO:0010533)2.56379503
81cellular response to interferon-beta (GO:0035458)2.56286107
82positive regulation of interleukin-8 secretion (GO:2000484)2.55414429
83macromolecular complex disassembly (GO:0032984)2.55408025
84rRNA catabolic process (GO:0016075)2.54734323
85positive regulation of natural killer cell mediated immunity (GO:0002717)2.52195617
86negative regulation of mast cell activation (GO:0033004)2.49618683
87nuclear-transcribed mRNA catabolic process (GO:0000956)2.47424230
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.46963069
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.46726271
90regulation of interleukin-8 secretion (GO:2000482)2.44882831
91indole-containing compound catabolic process (GO:0042436)2.44453214
92indolalkylamine catabolic process (GO:0046218)2.44453214
93tryptophan catabolic process (GO:0006569)2.44453214
94GPI anchor metabolic process (GO:0006505)2.42873026
95deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.42736261
96ribonucleoprotein complex biogenesis (GO:0022613)2.42534390
97protein-cofactor linkage (GO:0018065)2.42403893
98positive regulation of cell killing (GO:0031343)2.41855785
99spliceosomal complex assembly (GO:0000245)2.40754561
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.39932360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.03863637
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.84560733
3EZH2_22144423_ChIP-Seq_EOC_Human3.48311893
4VDR_22108803_ChIP-Seq_LS180_Human3.28375261
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99153344
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.96099470
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67058024
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.60650989
9ZNF274_21170338_ChIP-Seq_K562_Hela2.56391928
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54839602
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52426599
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.24668966
13VDR_23849224_ChIP-Seq_CD4+_Human2.13649899
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08453267
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.05953876
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95620545
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95277112
18IGF1R_20145208_ChIP-Seq_DFB_Human1.91756301
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88725717
20EWS_26573619_Chip-Seq_HEK293_Human1.87914659
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84971491
22ELK1_19687146_ChIP-ChIP_HELA_Human1.83024909
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77699561
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72286783
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72109323
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69759168
27FOXP3_21729870_ChIP-Seq_TREG_Human1.68859199
28TP53_22573176_ChIP-Seq_HFKS_Human1.62900556
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62104271
30FUS_26573619_Chip-Seq_HEK293_Human1.60644087
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59868493
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.56691162
33MYC_18940864_ChIP-ChIP_HL60_Human1.56647635
34TAF15_26573619_Chip-Seq_HEK293_Human1.52291450
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52169712
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49981920
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48535701
38ER_23166858_ChIP-Seq_MCF-7_Human1.44990331
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40038484
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39022597
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.39022597
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37778127
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36813892
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36038271
45P300_19829295_ChIP-Seq_ESCs_Human1.35876258
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.35697672
47AR_20517297_ChIP-Seq_VCAP_Human1.33586878
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32927376
49SOX2_19829295_ChIP-Seq_ESCs_Human1.32298484
50NANOG_19829295_ChIP-Seq_ESCs_Human1.32298484
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31089120
52IRF1_19129219_ChIP-ChIP_H3396_Human1.29833284
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29262417
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.28017125
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.24331637
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.21910376
57BCAT_22108803_ChIP-Seq_LS180_Human1.21130867
58CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.21119836
59GATA3_26560356_Chip-Seq_TH2_Human1.19851747
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18832648
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18784778
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17593070
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.14880785
64NCOR_22424771_ChIP-Seq_293T_Human1.14638575
65TAF2_19829295_ChIP-Seq_ESCs_Human1.13748332
66NANOG_20526341_ChIP-Seq_ESCs_Human1.12103552
67FOXH1_21741376_ChIP-Seq_EPCs_Human1.11963270
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11128894
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09667915
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09376411
71PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09350189
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09190044
73RNF2_27304074_Chip-Seq_NSC_Mouse1.07890375
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07711000
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.06083533
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05845207
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05684417
78CBP_20019798_ChIP-Seq_JUKART_Human1.05684417
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.04069748
80GBX2_23144817_ChIP-Seq_PC3_Human1.03320011
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02523574
82MYC_19829295_ChIP-Seq_ESCs_Human1.00393145
83CBX2_27304074_Chip-Seq_ESCs_Mouse0.99783306
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.99764709
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99484003
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99428102
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98480952
88TTF2_22483619_ChIP-Seq_HELA_Human0.96461126
89MYB_26560356_Chip-Seq_TH2_Human0.95978148
90TCF4_22108803_ChIP-Seq_LS180_Human0.95795385
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95521429
92HOXB7_26014856_ChIP-Seq_BT474_Human0.94208098
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94180015
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90737538
95RBPJ_21746931_ChIP-Seq_IB4_Human0.88625561
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.88498552
97ERG_20517297_ChIP-Seq_VCAP_Human0.87336120
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.87107741
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85722022
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85509091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.40976412
2MP0005671_abnormal_response_to3.89014152
3MP0006292_abnormal_olfactory_placode3.02555871
4MP0001835_abnormal_antigen_presentation2.91368728
5MP0006072_abnormal_retinal_apoptosis2.30706927
6MP0004142_abnormal_muscle_tone2.27178139
7MP0008877_abnormal_DNA_methylation2.15061486
8MP0002102_abnormal_ear_morphology2.14757212
9MP0008872_abnormal_physiological_respon1.87214629
10MP0003806_abnormal_nucleotide_metabolis1.85461196
11MP0003646_muscle_fatigue1.85398678
12MP0002837_dystrophic_cardiac_calcinosis1.84181420
13MP0003878_abnormal_ear_physiology1.78999931
14MP0005377_hearing/vestibular/ear_phenot1.78999931
15MP0005551_abnormal_eye_electrophysiolog1.78870544
16MP0001873_stomach_inflammation1.75983711
17MP0009785_altered_susceptibility_to1.73630616
18MP0002163_abnormal_gland_morphology1.72228156
19MP0005645_abnormal_hypothalamus_physiol1.70897803
20MP0001968_abnormal_touch/_nociception1.66316259
21MP0001919_abnormal_reproductive_system1.64315324
22MP0009333_abnormal_splenocyte_physiolog1.60144348
23MP0005075_abnormal_melanosome_morpholog1.58088810
24MP0008875_abnormal_xenobiotic_pharmacok1.58000646
25MP0003880_abnormal_central_pattern1.56756367
26MP0001800_abnormal_humoral_immune1.56450969
27MP0004145_abnormal_muscle_electrophysio1.55094590
28MP0002736_abnormal_nociception_after1.52396109
29MP0005084_abnormal_gallbladder_morpholo1.52273349
30MP0004885_abnormal_endolymph1.51591540
31MP0005389_reproductive_system_phenotype1.51393879
32MP0003787_abnormal_imprinting1.46608909
33MP0001485_abnormal_pinna_reflex1.45773967
34MP0005646_abnormal_pituitary_gland1.45424710
35MP0001905_abnormal_dopamine_level1.42207864
36MP0004147_increased_porphyrin_level1.42121267
37MP0002148_abnormal_hypersensitivity_rea1.38817457
38MP0002138_abnormal_hepatobiliary_system1.37653069
39MP0000372_irregular_coat_pigmentation1.37652893
40MP0001790_abnormal_immune_system1.37229190
41MP0005387_immune_system_phenotype1.37229190
42MP0005379_endocrine/exocrine_gland_phen1.34653314
43MP0001984_abnormal_olfaction1.33855328
44MP0004742_abnormal_vestibular_system1.33279881
45MP0002272_abnormal_nervous_system1.32898267
46MP0002166_altered_tumor_susceptibility1.32815794
47MP0003763_abnormal_thymus_physiology1.31390765
48MP0005253_abnormal_eye_physiology1.31153234
49MP0001529_abnormal_vocalization1.30820918
50MP0003011_delayed_dark_adaptation1.27474470
51MP0005000_abnormal_immune_tolerance1.26755984
52MP0002653_abnormal_ependyma_morphology1.23815103
53MP0002723_abnormal_immune_serum1.22769965
54MP0008789_abnormal_olfactory_epithelium1.18518166
55MP0006276_abnormal_autonomic_nervous1.17432662
56MP0003195_calcinosis1.17086100
57MP0009745_abnormal_behavioral_response1.16119142
58MP0001986_abnormal_taste_sensitivity1.13038688
59MP0002420_abnormal_adaptive_immunity1.12420047
60MP0000631_abnormal_neuroendocrine_gland1.11631373
61MP0001819_abnormal_immune_cell1.10192265
62MP0002277_abnormal_respiratory_mucosa1.09993962
63MP0008995_early_reproductive_senescence1.09910317
64MP0000685_abnormal_immune_system1.09841957
65MP0003786_premature_aging1.08310754
66MP0002006_tumorigenesis1.07243259
67MP0002876_abnormal_thyroid_physiology1.06715153
68MP0002160_abnormal_reproductive_system1.05910828
69MP0001188_hyperpigmentation1.04457270
70MP0009764_decreased_sensitivity_to1.02782811
71MP0002452_abnormal_antigen_presenting1.01635681
72MP0003567_abnormal_fetal_cardiomyocyte1.00323530
73MP0001970_abnormal_pain_threshold1.00304305
74MP0003866_abnormal_defecation0.99158302
75MP0002095_abnormal_skin_pigmentation0.97087024
76MP0005025_abnormal_response_to0.95923708
77MP0001440_abnormal_grooming_behavior0.94209184
78MP0001293_anophthalmia0.92753768
79MP0010386_abnormal_urinary_bladder0.90379031
80MP0002733_abnormal_thermal_nociception0.90322675
81MP0001486_abnormal_startle_reflex0.88852733
82MP0005410_abnormal_fertilization0.88410983
83MP0005636_abnormal_mineral_homeostasis0.88297183
84MP0003122_maternal_imprinting0.85940699
85MP0002405_respiratory_system_inflammati0.84420131
86MP0009046_muscle_twitch0.84350748
87MP0002234_abnormal_pharynx_morphology0.83837838
88MP0002638_abnormal_pupillary_reflex0.83506049
89MP0006036_abnormal_mitochondrial_physio0.81851392
90MP0005195_abnormal_posterior_eye0.81383898
91MP0000716_abnormal_immune_system0.79469987
92MP0005174_abnormal_tail_pigmentation0.76780703
93MP0004133_heterotaxia0.76480490
94MP0000026_abnormal_inner_ear0.75504181
95MP0002184_abnormal_innervation0.75114960
96MP0003137_abnormal_impulse_conducting0.74287118
97MP0001963_abnormal_hearing_physiology0.73476830
98MP0000049_abnormal_middle_ear0.72776162
99MP0001853_heart_inflammation0.71609214
100MP0010155_abnormal_intestine_physiology0.69586577

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.27254207
2Mitochondrial inheritance (HP:0001427)4.61338793
3Abnormal mitochondria in muscle tissue (HP:0008316)4.59816571
4Progressive macrocephaly (HP:0004481)4.44116566
5Acute encephalopathy (HP:0006846)4.28369198
6Hepatocellular necrosis (HP:0001404)3.97248317
73-Methylglutaconic aciduria (HP:0003535)3.93540852
8Increased CSF lactate (HP:0002490)3.92910851
9IgG deficiency (HP:0004315)3.71128150
10Congenital stationary night blindness (HP:0007642)3.70181992
11Aplastic anemia (HP:0001915)3.53623237
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.46580946
13Reticulocytopenia (HP:0001896)3.42971051
14Hepatic necrosis (HP:0002605)3.42651314
15Elevated erythrocyte sedimentation rate (HP:0003565)3.30460137
16Increased hepatocellular lipid droplets (HP:0006565)3.27728793
17Cerebral edema (HP:0002181)3.23985079
18Hypoproteinemia (HP:0003075)3.23194359
19Abnormal rod and cone electroretinograms (HP:0008323)3.18651665
20Congenital, generalized hypertrichosis (HP:0004540)3.13197529
21Lipid accumulation in hepatocytes (HP:0006561)3.03279225
22Optic disc pallor (HP:0000543)2.88728673
23Molar tooth sign on MRI (HP:0002419)2.80745936
24Abnormality of midbrain morphology (HP:0002418)2.80745936
25Abnormality of cells of the erythroid lineage (HP:0012130)2.74125845
26Renal Fanconi syndrome (HP:0001994)2.71401710
27Abnormality of B cell number (HP:0010975)2.71132757
28Macrocytic anemia (HP:0001972)2.70736657
29Increased IgM level (HP:0003496)2.64185738
30Increased intramyocellular lipid droplets (HP:0012240)2.63234407
31Pancreatic cysts (HP:0001737)2.60677158
32Leukodystrophy (HP:0002415)2.52737970
33Colon cancer (HP:0003003)2.52202484
34Methylmalonic acidemia (HP:0002912)2.49756819
35Stomatitis (HP:0010280)2.46778528
36B lymphocytopenia (HP:0010976)2.46108318
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44867960
38Increased serum lactate (HP:0002151)2.44315139
39Severe combined immunodeficiency (HP:0004430)2.43865929
40Septo-optic dysplasia (HP:0100842)2.42902446
41Abolished electroretinogram (ERG) (HP:0000550)2.38715324
42Medial flaring of the eyebrow (HP:0010747)2.37199629
43Respiratory failure (HP:0002878)2.37124923
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.35294247
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.35294247
46Stenosis of the external auditory canal (HP:0000402)2.34276025
47Abnormal number of erythroid precursors (HP:0012131)2.32228186
48Lactic acidosis (HP:0003128)2.31546622
49Exertional dyspnea (HP:0002875)2.28896607
50Abnormality of T cell number (HP:0011839)2.27540309
51Decreased central vision (HP:0007663)2.25843171
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23506901
53T lymphocytopenia (HP:0005403)2.21410901
54Pancreatic fibrosis (HP:0100732)2.20529469
55Thyroiditis (HP:0100646)2.19662043
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18320492
57True hermaphroditism (HP:0010459)2.15793696
58Nephronophthisis (HP:0000090)2.15788596
59Increased muscle lipid content (HP:0009058)2.14583736
60Methylmalonic aciduria (HP:0012120)2.13413938
61Pendular nystagmus (HP:0012043)2.13299036
62Lethargy (HP:0001254)2.10875291
63Type 2 muscle fiber atrophy (HP:0003554)2.07670158
64Attenuation of retinal blood vessels (HP:0007843)2.06169308
65Abnormality of the renal cortex (HP:0011035)2.05600571
66Renal cortical cysts (HP:0000803)2.01044260
67Constricted visual fields (HP:0001133)1.99639559
68Exercise intolerance (HP:0003546)1.97853251
69Abnormality of the prostate (HP:0008775)1.96389812
70Pallor (HP:0000980)1.95978519
71Absent thumb (HP:0009777)1.94181217
72Pancytopenia (HP:0001876)1.93772109
73Abnormality of T cells (HP:0002843)1.93570457
74Abnormal ciliary motility (HP:0012262)1.88755078
75Hypoalbuminemia (HP:0003073)1.87647846
76Abnormal albumin level (HP:0012116)1.87647846
77Abnormal drinking behavior (HP:0030082)1.83545404
78Polydipsia (HP:0001959)1.83545404
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.83540011
80Abnormality of DNA repair (HP:0003254)1.82811191
81Glycosuria (HP:0003076)1.82188228
82Abnormality of urine glucose concentration (HP:0011016)1.82188228
83Abnormality of renal resorption (HP:0011038)1.82114359
84Abnormal respiratory motile cilium physiology (HP:0012261)1.81294830
85Abnormality of the renal medulla (HP:0100957)1.80698990
86Increased corneal curvature (HP:0100692)1.80332475
87Keratoconus (HP:0000563)1.80332475
88Autoimmune hemolytic anemia (HP:0001890)1.77060086
89Abnormality of eosinophils (HP:0001879)1.75394585
90Type II lissencephaly (HP:0007260)1.73199233
91Muscle fiber atrophy (HP:0100295)1.72325792
92Asplenia (HP:0001746)1.71102718
93Combined immunodeficiency (HP:0005387)1.70986760
94Sclerocornea (HP:0000647)1.69322434
95Gait imbalance (HP:0002141)1.69322265
96Congenital primary aphakia (HP:0007707)1.68939498
97IgM deficiency (HP:0002850)1.68752702
98X-linked dominant inheritance (HP:0001423)1.64301001
99Polyuria (HP:0000103)1.63894205
100Hyperalaninemia (HP:0003348)1.62652830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.14805447
2KDR2.91063072
3MAP4K22.68118609
4ADRBK22.53440092
5GRK12.52572885
6BCKDK2.41197153
7ZAK2.30651011
8WNK42.30105368
9STK162.25881788
10CDK192.22236923
11TLK12.14784133
12VRK22.13945532
13FRK2.04061923
14NUAK12.00289514
15MAP4K11.97274366
16PINK11.94226380
17MST41.85295026
18ITK1.84859961
19TEC1.83646790
20TESK21.82888670
21PASK1.80365442
22MAP3K121.76797516
23VRK11.59608955
24TAOK31.57351397
25TIE11.49829065
26WNK31.48796855
27DYRK21.43052264
28NME11.33559443
29SYK1.13819746
30OXSR11.10101021
31STK391.07443089
32CAMKK21.07025101
33INSRR1.03723779
34PRKCQ1.00917836
35MYLK1.00101800
36FES0.99153920
37BTK0.95944661
38RPS6KA50.94006788
39TRIM280.93929430
40GRK60.93260179
41TYRO30.89423472
42EIF2AK30.89153366
43MAPK130.88532926
44MAP2K70.87826495
45TNK20.87781362
46BMPR1B0.84826046
47CSNK1G30.81414550
48LCK0.80948309
49KIT0.80838027
50IKBKB0.79872990
51MAP3K110.79170758
52CSNK1G20.78860756
53BMPR20.76591840
54CAMKK10.76477948
55CSNK1G10.75170880
56LYN0.75021906
57LIMK10.72048237
58OBSCN0.71782099
59MUSK0.67783005
60RPS6KA40.65164025
61PRKCE0.59845670
62PRKACA0.59838365
63PIK3CA0.59360596
64CAMK10.59199615
65EPHA40.59030655
66CSNK1A1L0.58865744
67PRKCG0.57109090
68SCYL20.55854390
69CSK0.54242353
70PAK30.53860006
71PIK3CG0.53703363
72ERBB30.52839362
73AURKB0.51875521
74DAPK30.51639289
75MAP2K60.51172601
76NTRK20.49634422
77PIM10.49581627
78CAMK2A0.48523060
79MAP3K40.48475287
80PRKCA0.46882558
81CSNK2A20.46500898
82PHKG20.46412313
83PHKG10.46412313
84IGF1R0.46129387
85MAPK150.45898977
86TAF10.45280813
87NLK0.43791556
88CSF1R0.43615658
89CSNK2A10.43029197
90BCR0.41398657
91CSNK1A10.40551770
92SRPK10.40083418
93ADRBK10.39549226
94EIF2AK10.38771300
95TESK10.38265214
96MKNK10.37604162
97BUB10.35819949
98MKNK20.35762422
99GRK70.35506000
100MAPKAPK50.33515912

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.10534991
2Ribosome_Homo sapiens_hsa030104.06516242
3Proteasome_Homo sapiens_hsa030503.49616639
4Parkinsons disease_Homo sapiens_hsa050123.28074969
5Primary immunodeficiency_Homo sapiens_hsa053402.99622217
6Asthma_Homo sapiens_hsa053102.98695580
7Allograft rejection_Homo sapiens_hsa053302.97973858
8Autoimmune thyroid disease_Homo sapiens_hsa053202.90196951
9Protein export_Homo sapiens_hsa030602.84444604
10Graft-versus-host disease_Homo sapiens_hsa053322.71761070
11Type I diabetes mellitus_Homo sapiens_hsa049402.40019189
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.34051497
13RNA polymerase_Homo sapiens_hsa030202.28910295
14Alzheimers disease_Homo sapiens_hsa050102.25319960
15Huntingtons disease_Homo sapiens_hsa050162.13447875
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.09858547
17Cardiac muscle contraction_Homo sapiens_hsa042602.04848848
18Antigen processing and presentation_Homo sapiens_hsa046121.88598423
19Phototransduction_Homo sapiens_hsa047441.85032617
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66601461
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64844927
22Homologous recombination_Homo sapiens_hsa034401.49085454
23Hematopoietic cell lineage_Homo sapiens_hsa046401.44129343
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39312914
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34423919
26RNA degradation_Homo sapiens_hsa030181.34405591
27Rheumatoid arthritis_Homo sapiens_hsa053231.33914353
28Linoleic acid metabolism_Homo sapiens_hsa005911.33702083
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33036856
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27326128
31Nitrogen metabolism_Homo sapiens_hsa009101.04986173
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04882579
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04044085
34Basal transcription factors_Homo sapiens_hsa030220.97728718
35T cell receptor signaling pathway_Homo sapiens_hsa046600.95455687
36Pyrimidine metabolism_Homo sapiens_hsa002400.94695299
37Nucleotide excision repair_Homo sapiens_hsa034200.92443931
38Caffeine metabolism_Homo sapiens_hsa002320.91255515
39Fanconi anemia pathway_Homo sapiens_hsa034600.91039261
40Viral myocarditis_Homo sapiens_hsa054160.88290989
41Nicotine addiction_Homo sapiens_hsa050330.86283456
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85594657
43Spliceosome_Homo sapiens_hsa030400.84831502
44Chemical carcinogenesis_Homo sapiens_hsa052040.84443335
45Propanoate metabolism_Homo sapiens_hsa006400.82068796
46One carbon pool by folate_Homo sapiens_hsa006700.81648358
47Collecting duct acid secretion_Homo sapiens_hsa049660.80762230
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.80648646
49Mismatch repair_Homo sapiens_hsa034300.80014596
50Purine metabolism_Homo sapiens_hsa002300.78994644
51Olfactory transduction_Homo sapiens_hsa047400.78343498
52Systemic lupus erythematosus_Homo sapiens_hsa053220.76437907
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75752028
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73658270
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71469609
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68102282
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.67491339
58Retinol metabolism_Homo sapiens_hsa008300.64196747
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63196059
60Butanoate metabolism_Homo sapiens_hsa006500.61913629
61Ether lipid metabolism_Homo sapiens_hsa005650.61542260
62Staphylococcus aureus infection_Homo sapiens_hsa051500.61332329
63RNA transport_Homo sapiens_hsa030130.59584102
64Regulation of autophagy_Homo sapiens_hsa041400.59546959
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59461544
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54557622
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52300712
68Peroxisome_Homo sapiens_hsa041460.51645243
69Steroid biosynthesis_Homo sapiens_hsa001000.51182496
70Tryptophan metabolism_Homo sapiens_hsa003800.50917270
71Taste transduction_Homo sapiens_hsa047420.50650884
72Metabolic pathways_Homo sapiens_hsa011000.47730971
73Arachidonic acid metabolism_Homo sapiens_hsa005900.46818390
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.46804789
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45993048
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.45730970
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45079560
78Fat digestion and absorption_Homo sapiens_hsa049750.41826312
79Morphine addiction_Homo sapiens_hsa050320.41821077
80Selenocompound metabolism_Homo sapiens_hsa004500.38141686
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37870312
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36113853
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35373588
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33014695
85DNA replication_Homo sapiens_hsa030300.32254651
86GABAergic synapse_Homo sapiens_hsa047270.28525370
87Vitamin digestion and absorption_Homo sapiens_hsa049770.26170712
88Serotonergic synapse_Homo sapiens_hsa047260.25758007
89Measles_Homo sapiens_hsa051620.23322465
90Epstein-Barr virus infection_Homo sapiens_hsa051690.19929195
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19742930
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18221969
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.18200909
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18150291
95Salivary secretion_Homo sapiens_hsa049700.17957559
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.15231099
97Leishmaniasis_Homo sapiens_hsa051400.14305563
98Pyruvate metabolism_Homo sapiens_hsa006200.13236790
99Folate biosynthesis_Homo sapiens_hsa007900.12361645
100Glutamatergic synapse_Homo sapiens_hsa047240.10889681

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