

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 9.06354572 |
| 2 | viral transcription (GO:0019083) | 8.98010896 |
| 3 | translational termination (GO:0006415) | 8.68743168 |
| 4 | ribosomal small subunit biogenesis (GO:0042274) | 8.30073021 |
| 5 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 7.91119242 |
| 6 | cotranslational protein targeting to membrane (GO:0006613) | 7.83770534 |
| 7 | protein targeting to ER (GO:0045047) | 7.77850772 |
| 8 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 7.42248131 |
| 9 | translational elongation (GO:0006414) | 7.40304049 |
| 10 | protein localization to endoplasmic reticulum (GO:0070972) | 7.36469217 |
| 11 | maturation of SSU-rRNA (GO:0030490) | 6.81886937 |
| 12 | viral life cycle (GO:0019058) | 6.80426853 |
| 13 | cellular protein complex disassembly (GO:0043624) | 6.77034747 |
| 14 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 6.65552620 |
| 15 | translational initiation (GO:0006413) | 6.35471826 |
| 16 | ribosomal large subunit biogenesis (GO:0042273) | 5.90630977 |
| 17 | protein complex disassembly (GO:0043241) | 5.81285433 |
| 18 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.53467066 |
| 19 | macromolecular complex disassembly (GO:0032984) | 5.49910266 |
| 20 | ATP synthesis coupled proton transport (GO:0015986) | 5.24648421 |
| 21 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.24648421 |
| 22 | * translation (GO:0006412) | 5.20049618 |
| 23 | protein targeting to membrane (GO:0006612) | 5.17568060 |
| 24 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 4.90664691 |
| 25 | mRNA catabolic process (GO:0006402) | 4.64583748 |
| 26 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.59991110 |
| 27 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.41599689 |
| 28 | DNA deamination (GO:0045006) | 4.39267765 |
| 29 | RNA catabolic process (GO:0006401) | 4.28311613 |
| 30 | rRNA modification (GO:0000154) | 4.28238641 |
| 31 | establishment of integrated proviral latency (GO:0075713) | 4.11069358 |
| 32 | formation of translation preinitiation complex (GO:0001731) | 4.06998872 |
| 33 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.01697375 |
| 34 | rRNA methylation (GO:0031167) | 3.94336995 |
| 35 | ribosome assembly (GO:0042255) | 3.91219958 |
| 36 | cellular component biogenesis (GO:0044085) | 3.88923418 |
| 37 | DNA replication checkpoint (GO:0000076) | 3.84328219 |
| 38 | rRNA processing (GO:0006364) | 3.83402016 |
| 39 | ribosome biogenesis (GO:0042254) | 3.82718553 |
| 40 | respiratory electron transport chain (GO:0022904) | 3.75885620 |
| 41 | proteasome assembly (GO:0043248) | 3.74555118 |
| 42 | GTP biosynthetic process (GO:0006183) | 3.70677731 |
| 43 | mitotic metaphase plate congression (GO:0007080) | 3.70105732 |
| 44 | electron transport chain (GO:0022900) | 3.68744745 |
| 45 | rRNA metabolic process (GO:0016072) | 3.67871563 |
| 46 | establishment of protein localization to membrane (GO:0090150) | 3.65042734 |
| 47 | pseudouridine synthesis (GO:0001522) | 3.58015882 |
| 48 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.56818779 |
| 49 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.49964868 |
| 50 | histone exchange (GO:0043486) | 3.49659877 |
| 51 | protein targeting (GO:0006605) | 3.48935287 |
| 52 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.47950194 |
| 53 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.46260173 |
| 54 | UTP biosynthetic process (GO:0006228) | 3.45623373 |
| 55 | termination of RNA polymerase III transcription (GO:0006386) | 3.45538020 |
| 56 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.45538020 |
| 57 | regulation of translational fidelity (GO:0006450) | 3.43374248 |
| 58 | establishment of viral latency (GO:0019043) | 3.40826639 |
| 59 | establishment of protein localization to organelle (GO:0072594) | 3.35473488 |
| 60 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.34739216 |
| 61 | DNA replication-independent nucleosome organization (GO:0034724) | 3.34556266 |
| 62 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.34556266 |
| 63 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.32977373 |
| 64 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.30094810 |
| 65 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.29453941 |
| 66 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.27787914 |
| 67 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.25885101 |
| 68 | negative regulation of ligase activity (GO:0051352) | 3.25885101 |
| 69 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.23664160 |
| 70 | transcription from mitochondrial promoter (GO:0006390) | 3.23220652 |
| 71 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.22372313 |
| 72 | purine nucleobase biosynthetic process (GO:0009113) | 3.21989802 |
| 73 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.19983239 |
| 74 | spliceosomal snRNP assembly (GO:0000387) | 3.19979600 |
| 75 | nucleobase biosynthetic process (GO:0046112) | 3.19942011 |
| 76 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.17798075 |
| 77 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.17755206 |
| 78 | protein complex biogenesis (GO:0070271) | 3.17086256 |
| 79 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.16546731 |
| 80 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.16546731 |
| 81 | IMP biosynthetic process (GO:0006188) | 3.16544015 |
| 82 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.16457627 |
| 83 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.16457627 |
| 84 | protein localization to kinetochore (GO:0034501) | 3.15822168 |
| 85 | DNA strand elongation (GO:0022616) | 3.15728517 |
| 86 | maturation of 5.8S rRNA (GO:0000460) | 3.15234525 |
| 87 | transcription from RNA polymerase I promoter (GO:0006360) | 3.13481777 |
| 88 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.11247219 |
| 89 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.11247219 |
| 90 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.11247219 |
| 91 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.07539348 |
| 92 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.07440457 |
| 93 | NADH dehydrogenase complex assembly (GO:0010257) | 3.07440457 |
| 94 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.07440457 |
| 95 | regulation of mitochondrial translation (GO:0070129) | 3.07396368 |
| 96 | CTP metabolic process (GO:0046036) | 3.07099638 |
| 97 | CTP biosynthetic process (GO:0006241) | 3.07099638 |
| 98 | spliceosomal complex assembly (GO:0000245) | 3.07051801 |
| 99 | DNA-templated transcription, termination (GO:0006353) | 3.06571464 |
| 100 | chaperone-mediated protein transport (GO:0072321) | 3.05114627 |
| 101 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.04752728 |
| 102 | metaphase plate congression (GO:0051310) | 3.04628271 |
| 103 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.04419722 |
| 104 | ncRNA processing (GO:0034470) | 3.04016557 |
| 105 | 7-methylguanosine mRNA capping (GO:0006370) | 3.03546940 |
| 106 | telomere maintenance via recombination (GO:0000722) | 3.03368684 |
| 107 | UTP metabolic process (GO:0046051) | 3.03324046 |
| 108 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.02410684 |
| 109 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.02410684 |
| 110 | respiratory chain complex IV assembly (GO:0008535) | 3.02272390 |
| 111 | protein localization to mitochondrion (GO:0070585) | 3.01893029 |
| 112 | RNA capping (GO:0036260) | 3.00504336 |
| 113 | 7-methylguanosine RNA capping (GO:0009452) | 3.00504336 |
| 114 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.99965660 |
| 115 | DNA replication initiation (GO:0006270) | 2.99302088 |
| 116 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.99070206 |
| 117 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.98239758 |
| 118 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.98239758 |
| 119 | protein localization to chromosome, centromeric region (GO:0071459) | 2.98141961 |
| 120 | ncRNA metabolic process (GO:0034660) | 2.98035812 |
| 121 | establishment of protein localization to mitochondrion (GO:0072655) | 2.97939943 |
| 122 | CENP-A containing nucleosome assembly (GO:0034080) | 2.97927584 |
| 123 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.97101114 |
| 124 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.96758229 |
| 125 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.96621849 |
| 126 | kinetochore organization (GO:0051383) | 2.96012249 |
| 127 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.95816192 |
| 128 | protein targeting to mitochondrion (GO:0006626) | 2.95192209 |
| 129 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.92964982 |
| 130 | amino acid activation (GO:0043038) | 2.92603603 |
| 131 | tRNA aminoacylation (GO:0043039) | 2.92603603 |
| 132 | mitotic recombination (GO:0006312) | 2.90810781 |
| 133 | chromatin remodeling at centromere (GO:0031055) | 2.89874472 |
| 134 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.88593376 |
| 135 | oxidative phosphorylation (GO:0006119) | 2.88215053 |
| 136 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.87804103 |
| 137 | termination of RNA polymerase I transcription (GO:0006363) | 2.87504716 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 5.12202461 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.01108658 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.38408676 |
| 4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.30388385 |
| 5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.26245103 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.19052682 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.16853450 |
| 8 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.62200464 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.57952723 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.39828953 |
| 11 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.39328628 |
| 12 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.13899978 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.13307234 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.04918911 |
| 15 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.99958496 |
| 16 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.99503171 |
| 17 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.98432716 |
| 18 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.82732257 |
| 19 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.82289848 |
| 20 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.78209713 |
| 21 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.76520320 |
| 22 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.69955595 |
| 23 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.68055985 |
| 24 | * TTF2_22483619_ChIP-Seq_HELA_Human | 2.49945368 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.45329259 |
| 26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.38961581 |
| 27 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.30563879 |
| 28 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.22576309 |
| 29 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.18794291 |
| 30 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.16603946 |
| 31 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.12226669 |
| 32 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.02323420 |
| 33 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.97448071 |
| 34 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.97113161 |
| 35 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.93094895 |
| 36 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.92927611 |
| 37 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.92659221 |
| 38 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.91420227 |
| 39 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.80084316 |
| 40 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.77519629 |
| 41 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.75409642 |
| 42 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.74644706 |
| 43 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.72895645 |
| 44 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.72169255 |
| 45 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.72071720 |
| 46 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.65876798 |
| 47 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.65667700 |
| 48 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.60945576 |
| 49 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.56051888 |
| 50 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.52557966 |
| 51 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.51382411 |
| 52 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.48101556 |
| 53 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.47799171 |
| 54 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.45142065 |
| 55 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.43867524 |
| 56 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.41413667 |
| 57 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38218124 |
| 58 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.34255843 |
| 59 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.33702259 |
| 60 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.30984029 |
| 61 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.29664009 |
| 62 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.27563441 |
| 63 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.25118975 |
| 64 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.21636999 |
| 65 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.17395856 |
| 66 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.16428878 |
| 67 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.16388111 |
| 68 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.15271445 |
| 69 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.14269093 |
| 70 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.14063913 |
| 71 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.13627329 |
| 72 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.11207708 |
| 73 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.09857988 |
| 74 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.07894377 |
| 75 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.07578713 |
| 76 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.06800962 |
| 77 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.06582694 |
| 78 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.05892843 |
| 79 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.04531007 |
| 80 | EWS_26573619_Chip-Seq_HEK293_Human | 1.03823819 |
| 81 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.03740432 |
| 82 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.03419217 |
| 83 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.03414316 |
| 84 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.02911282 |
| 85 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.02767212 |
| 86 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.01286857 |
| 87 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.98975280 |
| 88 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.97469275 |
| 89 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.96047365 |
| 90 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.95681945 |
| 91 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.92700034 |
| 92 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.91490409 |
| 93 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.90175759 |
| 94 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.89062160 |
| 95 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.86897674 |
| 96 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.86305102 |
| 97 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.84923600 |
| 98 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.84877411 |
| 99 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.82431606 |
| 100 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.82061525 |
| 101 | * SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.81633991 |
| 102 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.77522959 |
| 103 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.77055412 |
| 104 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.75496873 |
| 105 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.75041216 |
| 106 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.74848113 |
| 107 | * TFEB_21752829_ChIP-Seq_HELA_Human | 0.74683148 |
| 108 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.74652534 |
| 109 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.74317318 |
| 110 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.73565010 |
| 111 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.72051691 |
| 112 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.69777995 |
| 113 | FUS_26573619_Chip-Seq_HEK293_Human | 0.68241450 |
| 114 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.67841165 |
| 115 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.66384785 |
| 116 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.66084725 |
| 117 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.65390766 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 6.65422817 |
| 2 | MP0003693_abnormal_embryo_hatching | 4.24140365 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 3.76139986 |
| 4 | MP0003123_paternal_imprinting | 2.93376810 |
| 5 | MP0008057_abnormal_DNA_replication | 2.91110140 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 2.82467595 |
| 7 | MP0010094_abnormal_chromosome_stability | 2.71912685 |
| 8 | MP0003077_abnormal_cell_cycle | 2.55402237 |
| 9 | MP0006054_spinal_hemorrhage | 2.30471168 |
| 10 | MP0008058_abnormal_DNA_repair | 2.23062660 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.05164056 |
| 12 | MP0001529_abnormal_vocalization | 1.96477518 |
| 13 | MP0003111_abnormal_nucleus_morphology | 1.96112379 |
| 14 | MP0002396_abnormal_hematopoietic_system | 1.89300586 |
| 15 | MP0003786_premature_aging | 1.88229073 |
| 16 | MP0008007_abnormal_cellular_replicative | 1.88088721 |
| 17 | MP0002163_abnormal_gland_morphology | 1.84730919 |
| 18 | MP0009697_abnormal_copulation | 1.82677259 |
| 19 | MP0003122_maternal_imprinting | 1.82185041 |
| 20 | MP0003763_abnormal_thymus_physiology | 1.70617530 |
| 21 | MP0000490_abnormal_crypts_of | 1.67503704 |
| 22 | MP0002938_white_spotting | 1.64227715 |
| 23 | MP0009333_abnormal_splenocyte_physiolog | 1.60766304 |
| 24 | MP0001293_anophthalmia | 1.59054364 |
| 25 | MP0002796_impaired_skin_barrier | 1.58240463 |
| 26 | MP0005174_abnormal_tail_pigmentation | 1.55708078 |
| 27 | MP0003121_genomic_imprinting | 1.54966383 |
| 28 | MP0005379_endocrine/exocrine_gland_phen | 1.54206691 |
| 29 | MP0003890_abnormal_embryonic-extraembry | 1.52036078 |
| 30 | MP0002638_abnormal_pupillary_reflex | 1.50212961 |
| 31 | MP0002095_abnormal_skin_pigmentation | 1.45599981 |
| 32 | MP0006292_abnormal_olfactory_placode | 1.44700925 |
| 33 | MP0001853_heart_inflammation | 1.43106695 |
| 34 | MP0006036_abnormal_mitochondrial_physio | 1.41671193 |
| 35 | MP0006276_abnormal_autonomic_nervous | 1.39226421 |
| 36 | MP0005380_embryogenesis_phenotype | 1.36946750 |
| 37 | MP0001672_abnormal_embryogenesis/_devel | 1.36946750 |
| 38 | MP0004808_abnormal_hematopoietic_stem | 1.36625730 |
| 39 | MP0003315_abnormal_perineum_morphology | 1.36395464 |
| 40 | MP0002254_reproductive_system_inflammat | 1.33492189 |
| 41 | MP0006072_abnormal_retinal_apoptosis | 1.30677416 |
| 42 | MP0002132_abnormal_respiratory_system | 1.30512570 |
| 43 | MP0003941_abnormal_skin_development | 1.29724335 |
| 44 | MP0001188_hyperpigmentation | 1.27754893 |
| 45 | MP0001986_abnormal_taste_sensitivity | 1.27614242 |
| 46 | MP0010234_abnormal_vibrissa_follicle | 1.26746860 |
| 47 | MP0001881_abnormal_mammary_gland | 1.25882558 |
| 48 | MP0006035_abnormal_mitochondrial_morpho | 1.24568690 |
| 49 | MP0002085_abnormal_embryonic_tissue | 1.24021766 |
| 50 | MP0003984_embryonic_growth_retardation | 1.22121530 |
| 51 | MP0005408_hypopigmentation | 1.18997853 |
| 52 | MP0002088_abnormal_embryonic_growth/wei | 1.17450087 |
| 53 | MP0005671_abnormal_response_to | 1.17100742 |
| 54 | MP0005075_abnormal_melanosome_morpholog | 1.16408746 |
| 55 | MP0000703_abnormal_thymus_morphology | 1.14213216 |
| 56 | MP0002398_abnormal_bone_marrow | 1.13984764 |
| 57 | MP0002084_abnormal_developmental_patter | 1.13814764 |
| 58 | MP0002697_abnormal_eye_size | 1.13162332 |
| 59 | MP0000372_irregular_coat_pigmentation | 1.12792920 |
| 60 | MP0009785_altered_susceptibility_to | 1.12071387 |
| 61 | MP0003186_abnormal_redox_activity | 1.11973930 |
| 62 | MP0002722_abnormal_immune_system | 1.11969200 |
| 63 | MP0001835_abnormal_antigen_presentation | 1.11476072 |
| 64 | MP0010030_abnormal_orbit_morphology | 1.10612567 |
| 65 | MP0004185_abnormal_adipocyte_glucose | 1.09767037 |
| 66 | MP0002009_preneoplasia | 1.07260574 |
| 67 | MP0000350_abnormal_cell_proliferation | 1.06640773 |
| 68 | MP0002210_abnormal_sex_determination | 1.06165538 |
| 69 | MP0003136_yellow_coat_color | 1.04534961 |
| 70 | MP0005084_abnormal_gallbladder_morpholo | 1.03983732 |
| 71 | MP0000689_abnormal_spleen_morphology | 1.03637902 |
| 72 | MP0004197_abnormal_fetal_growth/weight/ | 1.03025229 |
| 73 | MP0003724_increased_susceptibility_to | 1.02989980 |
| 74 | MP0000762_abnormal_tongue_morphology | 1.01259447 |
| 75 | MP0002111_abnormal_tail_morphology | 1.01146136 |
| 76 | MP0004381_abnormal_hair_follicle | 1.00147347 |
| 77 | MP0002282_abnormal_trachea_morphology | 0.99920115 |
| 78 | MP0000358_abnormal_cell_content/ | 0.98534796 |
| 79 | MP0002166_altered_tumor_susceptibility | 0.98359260 |
| 80 | MP0003937_abnormal_limbs/digits/tail_de | 0.97952708 |
| 81 | MP0002148_abnormal_hypersensitivity_rea | 0.97121236 |
| 82 | MP0001545_abnormal_hematopoietic_system | 0.96819495 |
| 83 | MP0005397_hematopoietic_system_phenotyp | 0.96819495 |
| 84 | MP0001905_abnormal_dopamine_level | 0.95997718 |
| 85 | MP0002277_abnormal_respiratory_mucosa | 0.95943310 |
| 86 | MP0000313_abnormal_cell_death | 0.95283396 |
| 87 | MP0001286_abnormal_eye_development | 0.94795559 |
| 88 | MP0000685_abnormal_immune_system | 0.94681019 |
| 89 | MP0002019_abnormal_tumor_incidence | 0.94207107 |
| 90 | MP0005220_abnormal_exocrine_pancreas | 0.92662664 |
| 91 | MP0002086_abnormal_extraembryonic_tissu | 0.92569932 |
| 92 | MP0002006_tumorigenesis | 0.92198744 |
| 93 | MP0002877_abnormal_melanocyte_morpholog | 0.90835005 |
| 94 | MP0010352_gastrointestinal_tract_polyps | 0.89817662 |
| 95 | MP0002429_abnormal_blood_cell | 0.88929331 |
| 96 | MP0004133_heterotaxia | 0.88312894 |
| 97 | MP0004147_increased_porphyrin_level | 0.87206916 |
| 98 | MP0002420_abnormal_adaptive_immunity | 0.86355785 |
| 99 | MP0001730_embryonic_growth_arrest | 0.85727223 |
| 100 | MP0002751_abnormal_autonomic_nervous | 0.85303318 |
| 101 | MP0001819_abnormal_immune_cell | 0.82722709 |
| 102 | MP0005389_reproductive_system_phenotype | 0.82275544 |
| 103 | MP0000716_abnormal_immune_system | 0.81461331 |
| 104 | MP0001145_abnormal_male_reproductive | 0.81436707 |
| 105 | MP0001800_abnormal_humoral_immune | 0.81147197 |
| 106 | MP0008877_abnormal_DNA_methylation | 0.80531106 |
| 107 | MP0002405_respiratory_system_inflammati | 0.80070854 |
| 108 | MP0003567_abnormal_fetal_cardiomyocyte | 0.79838924 |
| 109 | MP0000049_abnormal_middle_ear | 0.79828111 |
| 110 | MP0010386_abnormal_urinary_bladder | 0.79669912 |
| 111 | MP0009672_abnormal_birth_weight | 0.79650639 |
| 112 | MP0001919_abnormal_reproductive_system | 0.78959030 |
| 113 | MP0002160_abnormal_reproductive_system | 0.78947314 |
| 114 | MP0000627_abnormal_mammary_gland | 0.77306861 |
| 115 | MP0005000_abnormal_immune_tolerance | 0.77266208 |
| 116 | MP0000858_altered_metastatic_potential | 0.76483101 |
| 117 | MP0001873_stomach_inflammation | 0.75710882 |
| 118 | MP0005503_abnormal_tendon_morphology | 0.74746937 |
| 119 | MP0009250_abnormal_appendicular_skeleto | 0.74170562 |
| 120 | MP0003718_maternal_effect | 0.73872653 |
| 121 | MP0005645_abnormal_hypothalamus_physiol | 0.73274560 |
| 122 | MP0010307_abnormal_tumor_latency | 0.73233955 |
| 123 | MP0001727_abnormal_embryo_implantation | 0.72689265 |
| 124 | MP0005409_darkened_coat_color | 0.72620648 |
| 125 | MP0001697_abnormal_embryo_size | 0.72397951 |
| 126 | MP0008789_abnormal_olfactory_epithelium | 0.71641409 |
| 127 | MP0002723_abnormal_immune_serum | 0.71544966 |
| 128 | MP0001929_abnormal_gametogenesis | 0.71078414 |
| 129 | MP0003866_abnormal_defecation | 0.70885545 |
| 130 | MP0002102_abnormal_ear_morphology | 0.70106282 |
| 131 | MP0002452_abnormal_antigen_presenting | 0.69934810 |
| 132 | MP0005501_abnormal_skin_physiology | 0.69700107 |
| 133 | MP0000653_abnormal_sex_gland | 0.69344907 |
| 134 | MP0002693_abnormal_pancreas_physiology | 0.69077178 |
| 135 | MP0002080_prenatal_lethality | 0.69004760 |
| 136 | MP0003755_abnormal_palate_morphology | 0.68914032 |
| 137 | MP0000579_abnormal_nail_morphology | 0.68492535 |
| 138 | MP0002177_abnormal_outer_ear | 0.68429219 |
| 139 | MP0002060_abnormal_skin_morphology | 0.67804907 |
| 140 | MP0005171_absent_coat_pigmentation | 0.67667333 |
| 141 | MP0009053_abnormal_anal_canal | 0.63729324 |
| 142 | MP0003936_abnormal_reproductive_system | 0.63374888 |
| 143 | MP0001764_abnormal_homeostasis | 0.61954342 |
| 144 | MP0001186_pigmentation_phenotype | 0.60964302 |
| 145 | MP0001119_abnormal_female_reproductive | 0.60962515 |
| 146 | MP0002233_abnormal_nose_morphology | 0.60925912 |
| 147 | MP0005395_other_phenotype | 0.59726956 |
| 148 | MP0001340_abnormal_eyelid_morphology | 0.58486684 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 8.74930595 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 7.91311472 |
| 3 | Reticulocytopenia (HP:0001896) | 6.59843800 |
| 4 | Macrocytic anemia (HP:0001972) | 5.33643531 |
| 5 | Pallor (HP:0000980) | 5.24796273 |
| 6 | Acute necrotizing encephalopathy (HP:0006965) | 4.93483608 |
| 7 | Mitochondrial inheritance (HP:0001427) | 4.58513530 |
| 8 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.50759079 |
| 9 | Aplastic anemia (HP:0001915) | 4.38215465 |
| 10 | Increased hepatocellular lipid droplets (HP:0006565) | 4.18841210 |
| 11 | Progressive macrocephaly (HP:0004481) | 4.00677172 |
| 12 | Increased CSF lactate (HP:0002490) | 3.89311720 |
| 13 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.73703694 |
| 14 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.73703694 |
| 15 | Acute encephalopathy (HP:0006846) | 3.70460455 |
| 16 | Hepatocellular necrosis (HP:0001404) | 3.68911148 |
| 17 | Lipid accumulation in hepatocytes (HP:0006561) | 3.60068282 |
| 18 | 11 pairs of ribs (HP:0000878) | 3.54990033 |
| 19 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.50150029 |
| 20 | Renal Fanconi syndrome (HP:0001994) | 3.30651881 |
| 21 | Chromsome breakage (HP:0040012) | 3.24069099 |
| 22 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.23808864 |
| 23 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.18321511 |
| 24 | Exertional dyspnea (HP:0002875) | 3.17468538 |
| 25 | Colon cancer (HP:0003003) | 3.16717707 |
| 26 | Oral leukoplakia (HP:0002745) | 3.16058229 |
| 27 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.11676057 |
| 28 | Increased intramyocellular lipid droplets (HP:0012240) | 3.07473264 |
| 29 | Hepatic necrosis (HP:0002605) | 3.01132049 |
| 30 | 3-Methylglutaconic aciduria (HP:0003535) | 2.99060715 |
| 31 | Exercise intolerance (HP:0003546) | 2.98212269 |
| 32 | Respiratory difficulties (HP:0002880) | 2.96814553 |
| 33 | Meckel diverticulum (HP:0002245) | 2.93597481 |
| 34 | Abnormality of methionine metabolism (HP:0010901) | 2.90188410 |
| 35 | Type I transferrin isoform profile (HP:0003642) | 2.89874178 |
| 36 | Thrombocytosis (HP:0001894) | 2.89563810 |
| 37 | Hypoplasia of the pons (HP:0012110) | 2.88647712 |
| 38 | Amniotic constriction ring (HP:0009775) | 2.83330810 |
| 39 | Abnormality of placental membranes (HP:0011409) | 2.83330810 |
| 40 | Abnormality of the pons (HP:0007361) | 2.81140793 |
| 41 | Abnormality of the ileum (HP:0001549) | 2.78655297 |
| 42 | Increased serum lactate (HP:0002151) | 2.75344983 |
| 43 | Abnormality of chromosome stability (HP:0003220) | 2.73405282 |
| 44 | Irregular epiphyses (HP:0010582) | 2.64504054 |
| 45 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.59991594 |
| 46 | Abnormal hemoglobin (HP:0011902) | 2.57347538 |
| 47 | Megaloblastic anemia (HP:0001889) | 2.55811889 |
| 48 | Birth length less than 3rd percentile (HP:0003561) | 2.54937361 |
| 49 | Homocystinuria (HP:0002156) | 2.51110823 |
| 50 | Abnormality of homocysteine metabolism (HP:0010919) | 2.51110823 |
| 51 | Lactic acidosis (HP:0003128) | 2.46513593 |
| 52 | Glossoptosis (HP:0000162) | 2.45082195 |
| 53 | Increased muscle lipid content (HP:0009058) | 2.40136778 |
| 54 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.38456815 |
| 55 | Congenital, generalized hypertrichosis (HP:0004540) | 2.37197523 |
| 56 | Depressed nasal ridge (HP:0000457) | 2.37158238 |
| 57 | Abnormality of serum amino acid levels (HP:0003112) | 2.36572716 |
| 58 | Progressive muscle weakness (HP:0003323) | 2.35355420 |
| 59 | Respiratory failure (HP:0002878) | 2.33527818 |
| 60 | Microvesicular hepatic steatosis (HP:0001414) | 2.30892917 |
| 61 | Methylmalonic acidemia (HP:0002912) | 2.30565647 |
| 62 | Rough bone trabeculation (HP:0100670) | 2.28302110 |
| 63 | Cerebral edema (HP:0002181) | 2.25300530 |
| 64 | Squamous cell carcinoma (HP:0002860) | 2.22225105 |
| 65 | Stenosis of the external auditory canal (HP:0000402) | 2.20996420 |
| 66 | Abnormal protein glycosylation (HP:0012346) | 2.16689333 |
| 67 | Abnormal glycosylation (HP:0012345) | 2.16689333 |
| 68 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.16689333 |
| 69 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.16689333 |
| 70 | Microretrognathia (HP:0000308) | 2.16644527 |
| 71 | Septo-optic dysplasia (HP:0100842) | 2.16007515 |
| 72 | Optic disc pallor (HP:0000543) | 2.15310888 |
| 73 | IgM deficiency (HP:0002850) | 2.13141036 |
| 74 | Hypothermia (HP:0002045) | 2.12477309 |
| 75 | Absent thumb (HP:0009777) | 2.12018076 |
| 76 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.11006649 |
| 77 | Carpal bone hypoplasia (HP:0001498) | 2.10759439 |
| 78 | Abnormality of alanine metabolism (HP:0010916) | 2.08886618 |
| 79 | Hyperalaninemia (HP:0003348) | 2.08886618 |
| 80 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.08886618 |
| 81 | Methylmalonic aciduria (HP:0012120) | 2.08518912 |
| 82 | Small intestinal stenosis (HP:0012848) | 2.07054211 |
| 83 | Duodenal stenosis (HP:0100867) | 2.07054211 |
| 84 | Abnormality of reticulocytes (HP:0004312) | 2.06761678 |
| 85 | Abnormal lung lobation (HP:0002101) | 2.06077923 |
| 86 | Asplenia (HP:0001746) | 2.04724684 |
| 87 | Trismus (HP:0000211) | 1.99230120 |
| 88 | Sparse eyelashes (HP:0000653) | 1.97860840 |
| 89 | Abnormality of renal resorption (HP:0011038) | 1.97451498 |
| 90 | Pancytopenia (HP:0001876) | 1.97435153 |
| 91 | Horseshoe kidney (HP:0000085) | 1.96846791 |
| 92 | Testicular atrophy (HP:0000029) | 1.96675760 |
| 93 | Missing ribs (HP:0000921) | 1.95418752 |
| 94 | Premature graying of hair (HP:0002216) | 1.94004807 |
| 95 | Progressive external ophthalmoplegia (HP:0000590) | 1.92407126 |
| 96 | Leukodystrophy (HP:0002415) | 1.92244915 |
| 97 | Abnormality of the axillary hair (HP:0100134) | 1.91187521 |
| 98 | Abnormality of secondary sexual hair (HP:0009888) | 1.91187521 |
| 99 | IgA deficiency (HP:0002720) | 1.89794319 |
| 100 | Selective tooth agenesis (HP:0001592) | 1.87755839 |
| 101 | Sensory axonal neuropathy (HP:0003390) | 1.87611278 |
| 102 | Reduced antithrombin III activity (HP:0001976) | 1.85044277 |
| 103 | Abnormal number of incisors (HP:0011064) | 1.84628666 |
| 104 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.84579496 |
| 105 | Lethargy (HP:0001254) | 1.82406397 |
| 106 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.81462426 |
| 107 | Muscle fiber atrophy (HP:0100295) | 1.75707394 |
| 108 | Abnormality of the carotid arteries (HP:0005344) | 1.75460148 |
| 109 | Neoplasm of the colon (HP:0100273) | 1.74973839 |
| 110 | Migraine (HP:0002076) | 1.74628907 |
| 111 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.74321021 |
| 112 | Myelodysplasia (HP:0002863) | 1.73280668 |
| 113 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.72760303 |
| 114 | Tracheoesophageal fistula (HP:0002575) | 1.72164155 |
| 115 | Hyperphosphaturia (HP:0003109) | 1.71421569 |
| 116 | Increased serum pyruvate (HP:0003542) | 1.69626584 |
| 117 | Hypoplasia of the radius (HP:0002984) | 1.69151671 |
| 118 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.68192233 |
| 119 | Cellular immunodeficiency (HP:0005374) | 1.67933671 |
| 120 | Thick lower lip vermilion (HP:0000179) | 1.66403343 |
| 121 | Severe visual impairment (HP:0001141) | 1.64494593 |
| 122 | Triphalangeal thumb (HP:0001199) | 1.64010166 |
| 123 | Genu varum (HP:0002970) | 1.63252631 |
| 124 | Partial duplication of thumb phalanx (HP:0009944) | 1.61791570 |
| 125 | Woolly hair (HP:0002224) | 1.59548654 |
| 126 | Abnormality of the preputium (HP:0100587) | 1.57464505 |
| 127 | Type 2 muscle fiber atrophy (HP:0003554) | 1.56490666 |
| 128 | Breast hypoplasia (HP:0003187) | 1.55873576 |
| 129 | Metaphyseal dysplasia (HP:0100255) | 1.55535090 |
| 130 | Emotional lability (HP:0000712) | 1.54828055 |
| 131 | Abnormal trabecular bone morphology (HP:0100671) | 1.53903814 |
| 132 | Multiple enchondromatosis (HP:0005701) | 1.52973631 |
| 133 | Partial duplication of the phalanx of hand (HP:0009999) | 1.52381011 |
| 134 | Facial cleft (HP:0002006) | 1.52285661 |
| 135 | True hermaphroditism (HP:0010459) | 1.51360592 |
| 136 | Cleft eyelid (HP:0000625) | 1.50306177 |
| 137 | Neoplasm of the pancreas (HP:0002894) | 1.46889602 |
| 138 | Lymphoma (HP:0002665) | 1.46072816 |
| 139 | Parakeratosis (HP:0001036) | 1.44429770 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 4.74325570 |
| 2 | VRK2 | 3.94156833 |
| 3 | STK16 | 3.75401549 |
| 4 | WEE1 | 3.44727166 |
| 5 | BUB1 | 3.41256946 |
| 6 | ZAK | 3.17512661 |
| 7 | VRK1 | 3.13913535 |
| 8 | EIF2AK1 | 2.75503549 |
| 9 | TAF1 | 2.54486401 |
| 10 | EIF2AK3 | 2.53266748 |
| 11 | TTK | 2.51076074 |
| 12 | NEK1 | 2.46658995 |
| 13 | NME1 | 2.45019289 |
| 14 | MAP3K12 | 2.41226913 |
| 15 | MST4 | 2.28990254 |
| 16 | RPS6KB2 | 2.26503944 |
| 17 | PASK | 2.24685050 |
| 18 | SRPK1 | 2.14983518 |
| 19 | PIM2 | 2.08890820 |
| 20 | CDC7 | 2.04101023 |
| 21 | ACVR1B | 1.85505484 |
| 22 | BRSK2 | 1.76520488 |
| 23 | TGFBR1 | 1.75782086 |
| 24 | MKNK1 | 1.73651353 |
| 25 | TNIK | 1.55100505 |
| 26 | CDK19 | 1.51684001 |
| 27 | TSSK6 | 1.51192600 |
| 28 | DYRK3 | 1.47334289 |
| 29 | LRRK2 | 1.45847562 |
| 30 | TLK1 | 1.41492539 |
| 31 | TEC | 1.35291309 |
| 32 | CDK8 | 1.32625379 |
| 33 | NUAK1 | 1.27406922 |
| 34 | MAPKAPK3 | 1.27181454 |
| 35 | FLT3 | 1.24377673 |
| 36 | WNK4 | 1.20744449 |
| 37 | STK39 | 1.20744030 |
| 38 | AURKB | 1.14160093 |
| 39 | GRK7 | 1.09089737 |
| 40 | PLK4 | 1.04819404 |
| 41 | ADRBK2 | 1.03621807 |
| 42 | MAPKAPK5 | 1.00880954 |
| 43 | MUSK | 1.00208442 |
| 44 | SCYL2 | 0.98812598 |
| 45 | TESK2 | 0.98789552 |
| 46 | CDK7 | 0.97100634 |
| 47 | MAPK15 | 0.94799517 |
| 48 | PIK3CG | 0.94490497 |
| 49 | STK24 | 0.94303873 |
| 50 | PLK1 | 0.94216839 |
| 51 | SMG1 | 0.93289141 |
| 52 | MKNK2 | 0.90978332 |
| 53 | ARAF | 0.90719352 |
| 54 | STK3 | 0.90649065 |
| 55 | MAP4K1 | 0.89239594 |
| 56 | MYLK | 0.89153905 |
| 57 | AURKA | 0.88683079 |
| 58 | KDR | 0.87965694 |
| 59 | BTK | 0.87324518 |
| 60 | STK4 | 0.84832561 |
| 61 | CSNK2A2 | 0.84582309 |
| 62 | PDK2 | 0.84346255 |
| 63 | ALK | 0.83123771 |
| 64 | ILK | 0.81206668 |
| 65 | PBK | 0.81119325 |
| 66 | PLK3 | 0.81046030 |
| 67 | BMPR1B | 0.79969375 |
| 68 | IRAK3 | 0.79288627 |
| 69 | MAP3K9 | 0.76985618 |
| 70 | CSNK2A1 | 0.76922466 |
| 71 | MAP3K11 | 0.76713578 |
| 72 | RPS6KA4 | 0.76584963 |
| 73 | TESK1 | 0.75678958 |
| 74 | MAP3K3 | 0.73978142 |
| 75 | CCNB1 | 0.72673080 |
| 76 | STK38L | 0.71496428 |
| 77 | ATR | 0.71293226 |
| 78 | MAP3K10 | 0.69963662 |
| 79 | IRAK4 | 0.69797208 |
| 80 | DAPK3 | 0.69783309 |
| 81 | NLK | 0.68743393 |
| 82 | MST1R | 0.68646610 |
| 83 | KIT | 0.68192782 |
| 84 | EIF2AK2 | 0.67721605 |
| 85 | TXK | 0.67249969 |
| 86 | BRSK1 | 0.63618044 |
| 87 | LATS2 | 0.63347054 |
| 88 | PAK4 | 0.61934912 |
| 89 | RPS6KA5 | 0.61810274 |
| 90 | ERBB4 | 0.60450577 |
| 91 | ATM | 0.59989724 |
| 92 | SYK | 0.57640266 |
| 93 | MAP2K6 | 0.56929569 |
| 94 | PNCK | 0.55534390 |
| 95 | BRAF | 0.54580628 |
| 96 | MAP2K3 | 0.53967423 |
| 97 | GRK6 | 0.53071101 |
| 98 | LYN | 0.52565298 |
| 99 | CAMKK2 | 0.52408230 |
| 100 | LIMK1 | 0.49072332 |
| 101 | CDK4 | 0.48662314 |
| 102 | OXSR1 | 0.48518836 |
| 103 | CDK3 | 0.48223238 |
| 104 | DYRK2 | 0.46866670 |
| 105 | NEK2 | 0.46633554 |
| 106 | PIM1 | 0.46175225 |
| 107 | DAPK1 | 0.44306012 |
| 108 | ZAP70 | 0.43878771 |
| 109 | YES1 | 0.43777112 |
| 110 | ADRBK1 | 0.43622859 |
| 111 | CSNK1E | 0.43059205 |
| 112 | BCKDK | 0.42571645 |
| 113 | PRKCI | 0.42415174 |
| 114 | IKBKB | 0.41588652 |
| 115 | EEF2K | 0.40235025 |
| 116 | FGFR1 | 0.39997458 |
| 117 | CDK1 | 0.39775611 |
| 118 | TNK2 | 0.39592140 |
| 119 | MAP3K8 | 0.39453013 |
| 120 | ABL2 | 0.38341916 |
| 121 | CDK2 | 0.37692853 |
| 122 | STK10 | 0.36778471 |
| 123 | MAP2K2 | 0.36669453 |
| 124 | CHEK2 | 0.35854058 |
| 125 | RAF1 | 0.35215493 |
| 126 | PAK2 | 0.35018309 |
| 127 | MELK | 0.34492938 |
| 128 | ERBB3 | 0.32883080 |
| 129 | GRK1 | 0.32878650 |
| 130 | CDK6 | 0.30976364 |
| 131 | LCK | 0.30975898 |
| 132 | PAK1 | 0.30966599 |
| 133 | IRAK1 | 0.30583062 |
| 134 | AKT2 | 0.29989747 |
| 135 | CHEK1 | 0.28566203 |
| 136 | CSNK1G1 | 0.26465408 |
| 137 | PRKDC | 0.23266239 |
| 138 | CLK1 | 0.20315269 |
| 139 | NEK9 | 0.18483756 |
| 140 | LATS1 | 0.18372632 |
| 141 | CDK9 | 0.17573455 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * Ribosome_Homo sapiens_hsa03010 | 7.16100481 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.02692743 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.68750951 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.43915299 |
| 5 | Protein export_Homo sapiens_hsa03060 | 3.33584059 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 3.33275359 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 3.33006978 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.95368931 |
| 9 | Spliceosome_Homo sapiens_hsa03040 | 2.81161979 |
| 10 | Huntingtons disease_Homo sapiens_hsa05016 | 2.52317810 |
| 11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.44541935 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.37723012 |
| 13 | Alzheimers disease_Homo sapiens_hsa05010 | 2.30559234 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.30217614 |
| 15 | Homologous recombination_Homo sapiens_hsa03440 | 2.11042432 |
| 16 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.01164249 |
| 17 | RNA transport_Homo sapiens_hsa03013 | 1.87338225 |
| 18 | Base excision repair_Homo sapiens_hsa03410 | 1.86781955 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.67350539 |
| 20 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.48647728 |
| 21 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.42624844 |
| 22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.37789987 |
| 23 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.35733715 |
| 24 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.33250229 |
| 25 | Cell cycle_Homo sapiens_hsa04110 | 1.29869508 |
| 26 | Purine metabolism_Homo sapiens_hsa00230 | 1.27653609 |
| 27 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.27214508 |
| 28 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.25861918 |
| 29 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.09187010 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.06681417 |
| 31 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.02374609 |
| 32 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.02324894 |
| 33 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.98404446 |
| 34 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.94680630 |
| 35 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.93070144 |
| 36 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.87338230 |
| 37 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.87269241 |
| 38 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.86859837 |
| 39 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.83918790 |
| 40 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.80856278 |
| 41 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.78417618 |
| 42 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.77541195 |
| 43 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.77264601 |
| 44 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.76679251 |
| 45 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.75903234 |
| 46 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.74669293 |
| 47 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.74006063 |
| 48 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.72891766 |
| 49 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.72760605 |
| 50 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.68673149 |
| 51 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.64887703 |
| 52 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.63065974 |
| 53 | Sulfur relay system_Homo sapiens_hsa04122 | 0.62604104 |
| 54 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.62283845 |
| 55 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.61666005 |
| 56 | Carbon metabolism_Homo sapiens_hsa01200 | 0.57420555 |
| 57 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.54369028 |
| 58 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.54043121 |
| 59 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.53111185 |
| 60 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.52840755 |
| 61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.51860950 |
| 62 | Alcoholism_Homo sapiens_hsa05034 | 0.51582399 |
| 63 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.49217392 |
| 64 | Metabolic pathways_Homo sapiens_hsa01100 | 0.46860224 |
| 65 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.44671700 |
| 66 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.43608017 |
| 67 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.43318191 |
| 68 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.42566869 |
| 69 | Legionellosis_Homo sapiens_hsa05134 | 0.42518712 |
| 70 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.41411699 |
| 71 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.34930970 |
| 72 | Allograft rejection_Homo sapiens_hsa05330 | 0.34716443 |
| 73 | Thyroid cancer_Homo sapiens_hsa05216 | 0.34249002 |
| 74 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.34239156 |
| 75 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.33220483 |
| 76 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.33209291 |
| 77 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.33104075 |
| 78 | Asthma_Homo sapiens_hsa05310 | 0.32458658 |
| 79 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.30192012 |
| 80 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.29863610 |
| 81 | HTLV-I infection_Homo sapiens_hsa05166 | 0.26679297 |
| 82 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.24339103 |
| 83 | Shigellosis_Homo sapiens_hsa05131 | 0.22525119 |
| 84 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.22216946 |
| 85 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.21468185 |
| 86 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.20996459 |
| 87 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.20849013 |
| 88 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.20815336 |
| 89 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.20435621 |
| 90 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.20232991 |
| 91 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.19780909 |
| 92 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.19325811 |
| 93 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.19148660 |
| 94 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.18517948 |
| 95 | Measles_Homo sapiens_hsa05162 | 0.18419869 |
| 96 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.17236849 |
| 97 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.16884742 |
| 98 | Hepatitis B_Homo sapiens_hsa05161 | 0.16788266 |
| 99 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.16166926 |
| 100 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.15889876 |
| 101 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.15755871 |
| 102 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.15268427 |
| 103 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.15263155 |
| 104 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.14191253 |
| 105 | Galactose metabolism_Homo sapiens_hsa00052 | 0.14180119 |
| 106 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.14096239 |
| 107 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.13791233 |
| 108 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.13546614 |
| 109 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.13266614 |
| 110 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.12954599 |
| 111 | Other glycan degradation_Homo sapiens_hsa00511 | 0.12916519 |
| 112 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.12881314 |
| 113 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.12454939 |
| 114 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.11845173 |
| 115 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.11324247 |
| 116 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.11109708 |
| 117 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.10765715 |
| 118 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.10342121 |
| 119 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.10289675 |
| 120 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.10128223 |
| 121 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.09588667 |
| 122 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.08305418 |
| 123 | Melanoma_Homo sapiens_hsa05218 | 0.07671963 |
| 124 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.07496858 |
| 125 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.07285350 |
| 126 | Apoptosis_Homo sapiens_hsa04210 | 0.06933324 |
| 127 | Peroxisome_Homo sapiens_hsa04146 | 0.06799548 |
| 128 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.06773088 |
| 129 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.06505880 |
| 130 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.06359773 |
| 131 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.05167828 |
| 132 | Pertussis_Homo sapiens_hsa05133 | 0.04977041 |
| 133 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.04454693 |
| 134 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.04069172 |
| 135 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.03250688 |
| 136 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.03235198 |
| 137 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.01009282 |
| 138 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | -0.0162009 |
| 139 | beta-Alanine metabolism_Homo sapiens_hsa00410 | -0.0019885 |

