ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.92843300
2	viral transcription (GO:0019083)	6.36657380
3	translational termination (GO:0006415)	6.01084383
4	ribosomal small subunit biogenesis (GO:0042274)	5.94579835
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.87320218
6	ATP synthesis coupled proton transport (GO:0015986)	5.87320218
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.66017540
8	translational elongation (GO:0006414)	5.30112849
9	maturation of SSU-rRNA (GO:0030490)	5.27058145
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.10640141
11	protein targeting to ER (GO:0045047)	5.05535028
12	cotranslational protein targeting to membrane (GO:0006613)	5.01895204
13	axon ensheathment in central nervous system (GO:0032291)	4.98350944
14	central nervous system myelination (GO:0022010)	4.98350944
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.88882548
16	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.76785584
17	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.76785584
18	protein localization to endoplasmic reticulum (GO:0070972)	4.74783912
19	viral life cycle (GO:0019058)	4.64844568
20	DNA deamination (GO:0045006)	4.63657634
21	water-soluble vitamin biosynthetic process (GO:0042364)	4.53685198
22	cellular protein complex disassembly (GO:0043624)	4.53319686
23	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.50281341
24	regulation of activation of Janus kinase activity (GO:0010533)	4.41180599
25	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.38958851
26	cell proliferation in forebrain (GO:0021846)	4.28971969
27	behavioral response to nicotine (GO:0035095)	4.26158958
28	ribosomal large subunit biogenesis (GO:0042273)	4.10816712
29	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.10642639
30	negative regulation of astrocyte differentiation (GO:0048712)	4.10557787
31	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.09224432
32	translational initiation (GO:0006413)	4.06370800
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.04588766
34	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.90675861
35	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.77412241
36	respiratory electron transport chain (GO:0022904)	3.76944576
37	protein complex disassembly (GO:0043241)	3.76121526
38	electron transport chain (GO:0022900)	3.74103786
39	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.61181555
40	macromolecular complex disassembly (GO:0032984)	3.59660541
41	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.59514405
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.59514405
43	NADH dehydrogenase complex assembly (GO:0010257)	3.59514405
44	activated T cell proliferation (GO:0050798)	3.58675118
45	pyrimidine nucleotide catabolic process (GO:0006244)	3.58374246
46	ribonucleoprotein complex biogenesis (GO:0022613)	3.53934844
47	translation (GO:0006412)	3.53882134
48	protein complex biogenesis (GO:0070271)	3.52330698
49	cellular component biogenesis (GO:0044085)	3.48745773
50	chaperone-mediated protein transport (GO:0072321)	3.43804600
51	protein neddylation (GO:0045116)	3.37325283
52	cytidine deamination (GO:0009972)	3.34692761
53	cytidine metabolic process (GO:0046087)	3.34692761
54	cytidine catabolic process (GO:0006216)	3.34692761
55	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.23884438
56	protein targeting to membrane (GO:0006612)	3.22768323
57	GTP biosynthetic process (GO:0006183)	3.21997142
58	sulfur amino acid catabolic process (GO:0000098)	3.20179806
59	hydrogen ion transmembrane transport (GO:1902600)	3.17588888
60	axonemal dynein complex assembly (GO:0070286)	3.12318678
61	auditory receptor cell differentiation (GO:0042491)	3.10233870
62	mitochondrial respiratory chain complex assembly (GO:0033108)	3.07753374
63	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.07346919
64	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.05464745
65	positive regulation of steroid hormone secretion (GO:2000833)	3.05047214
66	ATP biosynthetic process (GO:0006754)	3.02720533
67	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.01090916
68	proton transport (GO:0015992)	2.99382886
69	pseudouridine synthesis (GO:0001522)	2.97848321
70	regulation of mitochondrial translation (GO:0070129)	2.96039025
71	negative regulation of glial cell differentiation (GO:0045686)	2.95602500
72	hydrogen transport (GO:0006818)	2.94304260
73	protein-cofactor linkage (GO:0018065)	2.92213440
74	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.91451896
75	response to pheromone (GO:0019236)	2.86295226
76	folic acid-containing compound biosynthetic process (GO:0009396)	2.85395421
77	mRNA catabolic process (GO:0006402)	2.83839521
78	otic vesicle formation (GO:0030916)	2.82556860
79	negative regulation of adenylate cyclase activity (GO:0007194)	2.81025030
80	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.79829880
81	mannosylation (GO:0097502)	2.77449176
82	cysteine metabolic process (GO:0006534)	2.76572743
83	hypothalamus development (GO:0021854)	2.76003001
84	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.74462564
85	tRNA processing (GO:0008033)	2.73669910
86	neuron fate determination (GO:0048664)	2.73253868
87	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.72593225
88	negative regulation of lyase activity (GO:0051350)	2.72533503
89	DNA damage response, detection of DNA damage (GO:0042769)	2.72387815
90	dendritic spine morphogenesis (GO:0060997)	2.69003511
91	L-serine metabolic process (GO:0006563)	2.68243242
92	negative regulation of cyclase activity (GO:0031280)	2.67669916
93	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.65489020
94	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.61653272
95	regulation of regulatory T cell differentiation (GO:0045589)	2.61331281
96	indole-containing compound catabolic process (GO:0042436)	2.60883550
97	indolalkylamine catabolic process (GO:0046218)	2.60883550
98	tryptophan catabolic process (GO:0006569)	2.60883550
99	cilium or flagellum-dependent cell motility (GO:0001539)	2.60304339
100	UTP biosynthetic process (GO:0006228)	2.60141189

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.96062217
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.41212858
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.10168047
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.85320742
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.20470498
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.94666974
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.68800541
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.64041375
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.17876683
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.14582856
11	VDR_22108803_ChIP-Seq_LS180_Human	2.12209180
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.07380461
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.01548957
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.91171703
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.87765967
16	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.70891065
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.69146886
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.64273980
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60498609
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59738534
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.57159740
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.53058466
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.52933770
24	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.50003296
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.46275258
26	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.44504900
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.43052636
28	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.42501647
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.42460870
30	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.36226047
31	STAT1_20625510_ChIP-Seq_HELA_Human	1.35440896
32	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.32532645
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30682148
34	EWS_26573619_Chip-Seq_HEK293_Human	1.29069477
35	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.28793223
36	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.28194302
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27770019
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27770019
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.27502574
40	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.27095893
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26151593
42	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25512871
43	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25151745
44	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.24186632
45	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.24036539
46	AR_20517297_ChIP-Seq_VCAP_Human	1.23885347
47	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.23304734
48	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.21633610
49	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.20626299
50	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.20425399
51	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.19855267
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19552744
53	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.17253091
54	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16982407
55	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.15886060
56	NCOR_22424771_ChIP-Seq_293T_Human	1.15233302
57	ELK1_19687146_ChIP-ChIP_HELA_Human	1.15148586
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14980698
59	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.13000395
60	ERA_21632823_ChIP-Seq_H3396_Human	1.11111168
61	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.10464217
62	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.09959069
63	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.09283738
64	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.07684839
65	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.06640409
66	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06345404
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05925073
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05925073
69	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.05852167
70	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.05852167
71	MYC_19829295_ChIP-Seq_ESCs_Human	1.04896134
72	P53_21459846_ChIP-Seq_SAOS-2_Human	1.04166847
73	GABP_19822575_ChIP-Seq_HepG2_Human	1.03573042
74	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.03322293
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02401348
76	ERG_20517297_ChIP-Seq_VCAP_Human	1.01423178
77	XRN2_22483619_ChIP-Seq_HELA_Human	1.00222908
78	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.99847017
79	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.98847099
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97913814
81	P300_19829295_ChIP-Seq_ESCs_Human	0.97883666
82	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97647637
83	ER_23166858_ChIP-Seq_MCF-7_Human	0.97169467
84	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.96075256
85	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95587089
86	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.95243531
87	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93697734
88	PHF8_20622853_ChIP-Seq_HELA_Human	0.93640233
89	RNF2_27304074_Chip-Seq_NSC_Mouse	0.93385172
90	CTCF_27219007_Chip-Seq_Bcells_Human	0.92560107
91	FUS_26573619_Chip-Seq_HEK293_Human	0.91516936
92	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.91078299
93	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89744178
94	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89726051
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89453958
96	RBPJ_21746931_ChIP-Seq_IB4_Human	0.89110441
97	CTCF_20526341_ChIP-Seq_ESCs_Human	0.89085079
98	E2F1_20622854_ChIP-Seq_HELA_Human	0.88504460
99	BCAT_22108803_ChIP-Seq_LS180_Human	0.88461268
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88235995

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.33261686
2	MP0005360_urolithiasis	3.36067526
3	MP0004885_abnormal_endolymph	3.30961522
4	MP0006292_abnormal_olfactory_placode	3.16732288
5	MP0002277_abnormal_respiratory_mucosa	2.46803048
6	MP0003136_yellow_coat_color	2.40590070
7	MP0001485_abnormal_pinna_reflex	2.24296879
8	MP0003122_maternal_imprinting	2.19987639
9	MP0005377_hearing/vestibular/ear_phenot	2.19254409
10	MP0003878_abnormal_ear_physiology	2.19254409
11	MP0001968_abnormal_touch/_nociception	2.12654854
12	MP0000566_synostosis	2.11521585
13	MP0004147_increased_porphyrin_level	2.06525493
14	MP0006072_abnormal_retinal_apoptosis	2.04913406
15	MP0003283_abnormal_digestive_organ	2.00800126
16	MP0002736_abnormal_nociception_after	1.98071756
17	MP0005671_abnormal_response_to	1.97611548
18	MP0000049_abnormal_middle_ear	1.91029907
19	MP0002638_abnormal_pupillary_reflex	1.89800764
20	MP0000538_abnormal_urinary_bladder	1.86862977
21	MP0005646_abnormal_pituitary_gland	1.84544700
22	MP0005645_abnormal_hypothalamus_physiol	1.82221956
23	MP0001905_abnormal_dopamine_level	1.71255268
24	MP0003646_muscle_fatigue	1.67415834
25	MP0004142_abnormal_muscle_tone	1.66978599
26	MP0002163_abnormal_gland_morphology	1.65918186
27	MP0008995_early_reproductive_senescence	1.61948749
28	MP0000026_abnormal_inner_ear	1.58321649
29	MP0005379_endocrine/exocrine_gland_phen	1.55281468
30	MP0002095_abnormal_skin_pigmentation	1.53267870
31	MP0005551_abnormal_eye_electrophysiolog	1.52223136
32	MP0002876_abnormal_thyroid_physiology	1.44111172
33	MP0001919_abnormal_reproductive_system	1.42551226
34	MP0004858_abnormal_nervous_system	1.42410059
35	MP0002272_abnormal_nervous_system	1.38417392
36	MP0008872_abnormal_physiological_respon	1.36836580
37	MP0000631_abnormal_neuroendocrine_gland	1.36185085
38	MP0002653_abnormal_ependyma_morphology	1.35061126
39	MP0003880_abnormal_central_pattern	1.35031563
40	MP0002138_abnormal_hepatobiliary_system	1.34985957
41	MP0004133_heterotaxia	1.34543907
42	MP0004742_abnormal_vestibular_system	1.32558030
43	MP0002733_abnormal_thermal_nociception	1.31175684
44	MP0002249_abnormal_larynx_morphology	1.28418960
45	MP0002234_abnormal_pharynx_morphology	1.27661085
46	MP0003011_delayed_dark_adaptation	1.23245902
47	MP0002837_dystrophic_cardiac_calcinosis	1.23042120
48	MP0004145_abnormal_muscle_electrophysio	1.20910561
49	MP0002184_abnormal_innervation	1.17913767
50	MP0001970_abnormal_pain_threshold	1.17811070
51	MP0005084_abnormal_gallbladder_morpholo	1.16769119
52	MP0002938_white_spotting	1.16213461
53	MP0009046_muscle_twitch	1.11838902
54	MP0009745_abnormal_behavioral_response	1.11830951
55	MP0001963_abnormal_hearing_physiology	1.11405170
56	MP0002102_abnormal_ear_morphology	1.10940596
57	MP0004043_abnormal_pH_regulation	1.10391042
58	MP0005389_reproductive_system_phenotype	1.09665248
59	MP0003195_calcinosis	1.08897956
60	MP0003638_abnormal_response/metabolism_	1.05552708
61	MP0001486_abnormal_startle_reflex	1.04656321
62	MP0003121_genomic_imprinting	1.04276374
63	MP0001270_distended_abdomen	1.04096961
64	MP0001986_abnormal_taste_sensitivity	1.03094343
65	MP0003938_abnormal_ear_development	1.02103073
66	MP0002752_abnormal_somatic_nervous	1.00071123
67	MP0002735_abnormal_chemical_nociception	0.99152699
68	MP0009333_abnormal_splenocyte_physiolog	0.98863461
69	MP0005253_abnormal_eye_physiology	0.96915462
70	MP0010386_abnormal_urinary_bladder	0.96686844
71	MP0003315_abnormal_perineum_morphology	0.93749246
72	MP0002572_abnormal_emotion/affect_behav	0.92815000
73	MP0005670_abnormal_white_adipose	0.92597317
74	MP0008789_abnormal_olfactory_epithelium	0.92507505
75	MP0008877_abnormal_DNA_methylation	0.91891122
76	MP0001835_abnormal_antigen_presentation	0.90213078
77	MP0005195_abnormal_posterior_eye	0.89391591
78	MP0003693_abnormal_embryo_hatching	0.89327721
79	MP0009780_abnormal_chondrocyte_physiolo	0.88976111
80	MP0008875_abnormal_xenobiotic_pharmacok	0.88898422
81	MP0005410_abnormal_fertilization	0.86794238
82	MP0006276_abnormal_autonomic_nervous	0.85313343
83	MP0002063_abnormal_learning/memory/cond	0.85012742
84	MP0001440_abnormal_grooming_behavior	0.83228659
85	MP0003635_abnormal_synaptic_transmissio	0.81438410
86	MP0002734_abnormal_mechanical_nocicepti	0.80736299
87	MP0002160_abnormal_reproductive_system	0.80513674
88	MP0000372_irregular_coat_pigmentation	0.79059399
89	MP0000613_abnormal_salivary_gland	0.78367805
90	MP0005332_abnormal_amino_acid	0.77160515
91	MP0002282_abnormal_trachea_morphology	0.76132132
92	MP0001529_abnormal_vocalization	0.75496290
93	MP0003936_abnormal_reproductive_system	0.74891156
94	MP0000537_abnormal_urethra_morphology	0.73834626
95	MP0003252_abnormal_bile_duct	0.73030646
96	MP0001188_hyperpigmentation	0.72226061
97	MP0002557_abnormal_social/conspecific_i	0.72157159
98	MP0005174_abnormal_tail_pigmentation	0.71985118
99	MP0009250_abnormal_appendicular_skeleto	0.71736588
100	MP0003186_abnormal_redox_activity	0.71520642

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.14261759
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.11353211
3	Acute necrotizing encephalopathy (HP:0006965)	3.88329698
4	Abnormality of cells of the erythroid lineage (HP:0012130)	3.79659570
5	Abnormal rod and cone electroretinograms (HP:0008323)	3.55041811
6	Abnormal ciliary motility (HP:0012262)	3.48908456
7	Increased hepatocellular lipid droplets (HP:0006565)	3.47808733
8	Macrocytic anemia (HP:0001972)	3.41667519
9	Constricted visual fields (HP:0001133)	3.39159223
10	Lipid accumulation in hepatocytes (HP:0006561)	3.39053815
11	Mitochondrial inheritance (HP:0001427)	3.37160032
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.28820080
13	Abnormal number of erythroid precursors (HP:0012131)	3.20026843
14	Acute encephalopathy (HP:0006846)	3.17926312
15	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.17525040
16	Severe visual impairment (HP:0001141)	3.17111252
17	Progressive macrocephaly (HP:0004481)	3.13204238
18	Congenital stationary night blindness (HP:0007642)	3.09957961
19	Abnormal respiratory motile cilium physiology (HP:0012261)	3.09081754
20	Increased CSF lactate (HP:0002490)	3.08144498
21	Septo-optic dysplasia (HP:0100842)	3.07824019
22	Pancreatic fibrosis (HP:0100732)	2.99964766
23	Abnormal respiratory epithelium morphology (HP:0012253)	2.99473031
24	Abnormal respiratory motile cilium morphology (HP:0005938)	2.99473031
25	True hermaphroditism (HP:0010459)	2.98728063
26	Renal Fanconi syndrome (HP:0001994)	2.88926335
27	3-Methylglutaconic aciduria (HP:0003535)	2.86091718
28	Pendular nystagmus (HP:0012043)	2.80421258
29	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.78433838
30	Absent/shortened dynein arms (HP:0200106)	2.78433838
31	Pallor (HP:0000980)	2.74531678
32	Pancreatic cysts (HP:0001737)	2.74034540
33	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.68830250
34	Thickened helices (HP:0000391)	2.62768384
35	Hyperalaninemia (HP:0003348)	2.50717517
36	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.50717517
37	Abnormality of alanine metabolism (HP:0010916)	2.50717517
38	Elevated erythrocyte sedimentation rate (HP:0003565)	2.48940833
39	Cerebral edema (HP:0002181)	2.43826583
40	Maternal diabetes (HP:0009800)	2.42928549
41	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.41853019
42	Stenosis of the external auditory canal (HP:0000402)	2.40465786
43	Nephronophthisis (HP:0000090)	2.40071108
44	Abnormal sex determination (HP:0012244)	2.39833310
45	Sex reversal (HP:0012245)	2.39833310
46	Increased intramyocellular lipid droplets (HP:0012240)	2.39542222
47	Exertional dyspnea (HP:0002875)	2.31488841
48	Hyperglycinemia (HP:0002154)	2.29791846
49	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.29505394
50	Congenital, generalized hypertrichosis (HP:0004540)	2.28792597
51	Methylmalonic acidemia (HP:0002912)	2.24912753
52	Median cleft lip (HP:0000161)	2.24210047
53	Glycosuria (HP:0003076)	2.24126885
54	Abnormality of urine glucose concentration (HP:0011016)	2.24126885
55	Hyperphosphaturia (HP:0003109)	2.22873166
56	Absent septum pellucidum (HP:0001331)	2.21438327
57	Abnormality of cochlea (HP:0000375)	2.21257429
58	Absent thumb (HP:0009777)	2.18993330
59	Generalized aminoaciduria (HP:0002909)	2.18294751
60	Homocystinuria (HP:0002156)	2.15368056
61	Abnormality of homocysteine metabolism (HP:0010919)	2.15368056
62	Abolished electroretinogram (ERG) (HP:0000550)	2.14366090
63	Hypoplasia of the radius (HP:0002984)	2.11327953
64	Optic disc pallor (HP:0000543)	2.10614137
65	Hypoplasia of the ulna (HP:0003022)	2.10427224
66	Increased muscle lipid content (HP:0009058)	2.09754721
67	Abnormality of the middle phalanges of the toes (HP:0010183)	2.05240741
68	Partial duplication of thumb phalanx (HP:0009944)	2.04375050
69	Rib fusion (HP:0000902)	2.03985167
70	Rhinitis (HP:0012384)	2.03826824
71	Morphological abnormality of the inner ear (HP:0011390)	2.01711126
72	Asplenia (HP:0001746)	2.00806612
73	Increased serum lactate (HP:0002151)	1.99997373
74	Bony spicule pigmentary retinopathy (HP:0007737)	1.97126492
75	Chronic sinusitis (HP:0011109)	1.94460100
76	Abnormality of renal resorption (HP:0011038)	1.94438240
77	Male pseudohermaphroditism (HP:0000037)	1.94063031
78	Sclerocornea (HP:0000647)	1.94032736
79	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.93708043
80	IgG deficiency (HP:0004315)	1.89746863
81	Methylmalonic aciduria (HP:0012120)	1.89472507
82	Congenital sensorineural hearing impairment (HP:0008527)	1.89142817
83	Medial flaring of the eyebrow (HP:0010747)	1.88721111
84	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.88614263
85	11 pairs of ribs (HP:0000878)	1.88164063
86	Hepatocellular necrosis (HP:0001404)	1.86888883
87	Anencephaly (HP:0002323)	1.86818134
88	Postaxial foot polydactyly (HP:0001830)	1.85800489
89	Hepatic necrosis (HP:0002605)	1.85153600
90	Keratoconus (HP:0000563)	1.84953689
91	Increased corneal curvature (HP:0100692)	1.84953689
92	Triphalangeal thumb (HP:0001199)	1.84638523
93	Abnormality of midbrain morphology (HP:0002418)	1.84606373
94	Molar tooth sign on MRI (HP:0002419)	1.84606373
95	Myokymia (HP:0002411)	1.84245094
96	Cystic liver disease (HP:0006706)	1.83903229
97	Lethargy (HP:0001254)	1.82387768
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.82248922
99	Attenuation of retinal blood vessels (HP:0007843)	1.81439863
100	Exercise intolerance (HP:0003546)	1.79129437

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.43296640
2	BCKDK	3.17330342
3	EPHB2	2.85128353
4	ADRBK2	2.80948130
5	FES	2.55490788
6	GRK1	2.48800265
7	NTRK2	2.36712487
8	WNK3	2.18943269
9	KDR	2.17109013
10	CASK	2.11583920
11	GRK6	2.09332054
12	DYRK2	1.93801224
13	VRK2	1.91767721
14	LRRK2	1.89480599
15	PINK1	1.81370030
16	NME1	1.77392387
17	MAP4K1	1.75820936
18	CDK19	1.74609143
19	STK39	1.71728756
20	ZAK	1.69384453
21	WNK4	1.67126133
22	TLK1	1.64493880
23	MAP4K2	1.59242139
24	CAMK1	1.43827818
25	BMPR1B	1.36019434
26	FRK	1.35685836
27	TEC	1.32684380
28	MAP3K11	1.31300617
29	MUSK	1.29885532
30	OXSR1	1.21920058
31	LIMK1	1.18630066
32	MAP3K12	1.17466516
33	TESK2	1.16650341
34	BUB1	1.10664294
35	BTK	1.07262391
36	ADRBK1	1.05794757
37	PLK4	1.05527724
38	INSRR	1.03329047
39	NTRK3	1.02750781
40	SGK223	0.98929493
41	SGK494	0.98929493
42	ITK	0.98293423
43	PASK	0.95444156
44	STK16	0.92428704
45	PRKCG	0.89120930
46	CDC7	0.88854330
47	PRKCQ	0.88783103
48	VRK1	0.88767026
49	SYK	0.88203682
50	RPS6KA4	0.87138888
51	NUAK1	0.82102268
52	RPS6KA5	0.80297376
53	ERBB2	0.79924867
54	PNCK	0.77990657
55	JAK3	0.77832536
56	NME2	0.77192007
57	TIE1	0.75180161
58	MAPK15	0.73391431
59	LMTK2	0.69438138
60	PRKACA	0.66758943
61	CAMKK2	0.65729226
62	BRAF	0.64528170
63	ACVR1B	0.64216827
64	OBSCN	0.62829713
65	PRKCE	0.61058334
66	CSNK2A2	0.60916117
67	KIT	0.60187624
68	SGK2	0.60038249
69	GRK7	0.59848851
70	KSR1	0.56908901
71	PHKG1	0.56828471
72	PHKG2	0.56828471
73	PAK3	0.52665541
74	CDK8	0.52635398
75	LYN	0.51335346
76	TAF1	0.51137234
77	TGFBR1	0.50482854
78	PDK2	0.50287343
79	PRKCA	0.49723739
80	CSNK1A1	0.49450932
81	DYRK3	0.47201957
82	CSNK2A1	0.46313180
83	CSNK1G2	0.44620013
84	PLK1	0.43098815
85	AKT3	0.42701500
86	MAP3K9	0.42067996
87	CSNK1G3	0.41720512
88	MYLK	0.41035455
89	PIM1	0.40968042
90	LCK	0.40868099
91	TESK1	0.40694734
92	TRIM28	0.39999237
93	CSK	0.39215096
94	EIF2AK3	0.39194969
95	FER	0.38727015
96	PKN1	0.38082994
97	CAMK2G	0.37767886
98	MST4	0.37015492
99	IGF1R	0.35289928
100	TAOK3	0.35259673

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.86396907
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.30524128
3	Parkinsons disease_Homo sapiens_hsa05012	3.53746706
4	Proteasome_Homo sapiens_hsa03050	2.93163220
5	RNA polymerase_Homo sapiens_hsa03020	2.50331194
6	Huntingtons disease_Homo sapiens_hsa05016	2.49466237
7	Alzheimers disease_Homo sapiens_hsa05010	2.25512772
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.18613944
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.10519462
10	One carbon pool by folate_Homo sapiens_hsa00670	1.86177708
11	Primary immunodeficiency_Homo sapiens_hsa05340	1.79748640
12	Sulfur relay system_Homo sapiens_hsa04122	1.77625936
13	Homologous recombination_Homo sapiens_hsa03440	1.75648687
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.63436796
15	Basal transcription factors_Homo sapiens_hsa03022	1.59909154
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.55564874
17	Phototransduction_Homo sapiens_hsa04744	1.48048983
18	Nicotine addiction_Homo sapiens_hsa05033	1.47982098
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.46370287
20	Sulfur metabolism_Homo sapiens_hsa00920	1.45374469
21	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.40028861
22	Caffeine metabolism_Homo sapiens_hsa00232	1.39016603
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.35049066
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.31297366
25	Olfactory transduction_Homo sapiens_hsa04740	1.31158156
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.30165516
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.28067161
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.25503724
29	RNA degradation_Homo sapiens_hsa03018	1.24726811
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18601949
31	Peroxisome_Homo sapiens_hsa04146	1.17021733
32	Protein export_Homo sapiens_hsa03060	1.15412232
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.11206195
34	Morphine addiction_Homo sapiens_hsa05032	1.10799446
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.09724672
36	Retinol metabolism_Homo sapiens_hsa00830	1.09477611
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08968523
38	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.07239953
39	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.03949642
40	Spliceosome_Homo sapiens_hsa03040	1.03386176
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.03122637
42	Asthma_Homo sapiens_hsa05310	1.02070209
43	Allograft rejection_Homo sapiens_hsa05330	1.00147851
44	Purine metabolism_Homo sapiens_hsa00230	0.98175288
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.98062957
46	GABAergic synapse_Homo sapiens_hsa04727	0.95486177
47	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.95467471
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.92227164
49	Graft-versus-host disease_Homo sapiens_hsa05332	0.89180472
50	Butanoate metabolism_Homo sapiens_hsa00650	0.88092793
51	Folate biosynthesis_Homo sapiens_hsa00790	0.85567731
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.85058883
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83094126
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80119825
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78552947
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76976105
57	Type I diabetes mellitus_Homo sapiens_hsa04940	0.76930938
58	Taste transduction_Homo sapiens_hsa04742	0.74612552
59	Base excision repair_Homo sapiens_hsa03410	0.74396199
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72294568
61	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.71299480
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.70484172
63	Nucleotide excision repair_Homo sapiens_hsa03420	0.70028608
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69569740
65	Rheumatoid arthritis_Homo sapiens_hsa05323	0.68569452
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68120254
67	Propanoate metabolism_Homo sapiens_hsa00640	0.67545358
68	Metabolic pathways_Homo sapiens_hsa01100	0.67412027
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64969710
70	Mismatch repair_Homo sapiens_hsa03430	0.62809974
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.60872437
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60203249
73	RNA transport_Homo sapiens_hsa03013	0.56527559
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.53431209
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53147696
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.51954599
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51600984
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49906238
79	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.49565863
80	Antigen processing and presentation_Homo sapiens_hsa04612	0.46576661
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45273223
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.44644570
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44436762
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.44393478
85	DNA replication_Homo sapiens_hsa03030	0.44002126
86	ABC transporters_Homo sapiens_hsa02010	0.39069917
87	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.38558295
88	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.38464424
89	Serotonergic synapse_Homo sapiens_hsa04726	0.38322401
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37849285
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.36191283
92	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36037948
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32968491
94	Circadian entrainment_Homo sapiens_hsa04713	0.30840527
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.30285157
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.27443821
97	Mineral absorption_Homo sapiens_hsa04978	0.27135529
98	PPAR signaling pathway_Homo sapiens_hsa03320	0.26325306
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.26243718
100	Regulation of autophagy_Homo sapiens_hsa04140	0.26210337

RPL22P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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