ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.98857580
2	limb bud formation (GO:0060174)	5.85134324
3	viral transcription (GO:0019083)	5.63697547
4	translational termination (GO:0006415)	5.60780489
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.26682955
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.76270687
7	cotranslational protein targeting to membrane (GO:0006613)	4.66039735
8	protein targeting to ER (GO:0045047)	4.64676264
9	ATP synthesis coupled proton transport (GO:0015986)	4.64626671
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.64626671
11	ribosomal small subunit biogenesis (GO:0042274)	4.63805961
12	somite development (GO:0061053)	4.57148834
13	translational elongation (GO:0006414)	4.53816395
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.42635227
15	maturation of SSU-rRNA (GO:0030490)	4.42027635
16	protein localization to endoplasmic reticulum (GO:0070972)	4.34471115
17	chaperone-mediated protein transport (GO:0072321)	4.25950930
18	cellular protein complex disassembly (GO:0043624)	4.18375523
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.15577095
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.02936553
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.99431956
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.99431956
23	NADH dehydrogenase complex assembly (GO:0010257)	3.99431956
24	replication fork processing (GO:0031297)	3.96214007
25	protein complex biogenesis (GO:0070271)	3.92506338
26	viral life cycle (GO:0019058)	3.90485875
27	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.89687476
28	translational initiation (GO:0006413)	3.84025812
29	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.81318597
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.71150159
31	intraciliary transport (GO:0042073)	3.63869314
32	DNA deamination (GO:0045006)	3.60408613
33	base-excision repair, AP site formation (GO:0006285)	3.53985787
34	behavioral response to nicotine (GO:0035095)	3.52659003
35	cytochrome complex assembly (GO:0017004)	3.51972191
36	protein complex disassembly (GO:0043241)	3.49861801
37	GTP biosynthetic process (GO:0006183)	3.46292568
38	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.45691555
39	proteasome assembly (GO:0043248)	3.42215484
40	organ formation (GO:0048645)	3.39846437
41	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.39039877
42	respiratory chain complex IV assembly (GO:0008535)	3.36462905
43	translation (GO:0006412)	3.33154460
44	nephron epithelium morphogenesis (GO:0072088)	3.31363605
45	nephron tubule morphogenesis (GO:0072078)	3.31363605
46	macromolecular complex disassembly (GO:0032984)	3.31041654
47	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.30062485
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.25955504
49	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.24036816
50	negative regulation of axon extension involved in axon guidance (GO:0048843)	3.23189416
51	aldehyde catabolic process (GO:0046185)	3.21898029
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.21674349
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.21674349
54	platelet dense granule organization (GO:0060155)	3.21433612
55	prostate gland growth (GO:0060736)	3.21382282
56	lactate metabolic process (GO:0006089)	3.18175364
57	ATP biosynthetic process (GO:0006754)	3.17008683
58	regulation of mesoderm development (GO:2000380)	3.15748866
59	respiratory electron transport chain (GO:0022904)	3.05158706
60	dorsal/ventral neural tube patterning (GO:0021904)	3.02056391
61	electron transport chain (GO:0022900)	3.01833939
62	hindbrain development (GO:0030902)	3.01189504
63	left/right pattern formation (GO:0060972)	3.01155719
64	thyroid gland development (GO:0030878)	3.00592995
65	negative regulation of cAMP-mediated signaling (GO:0043951)	2.98701881
66	cellular component biogenesis (GO:0044085)	2.98019404
67	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.96292078
68	protein targeting to membrane (GO:0006612)	2.95504172
69	ribosomal large subunit biogenesis (GO:0042273)	2.94735752
70	termination of RNA polymerase III transcription (GO:0006386)	2.93876109
71	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.93876109
72	regulation of cilium movement (GO:0003352)	2.93140166
73	axoneme assembly (GO:0035082)	2.90312530
74	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.88231149
75	pyrimidine nucleotide catabolic process (GO:0006244)	2.87908822
76	UTP biosynthetic process (GO:0006228)	2.85572080
77	kinetochore assembly (GO:0051382)	2.85314642
78	regulation of glucokinase activity (GO:0033131)	2.83381609
79	regulation of hexokinase activity (GO:1903299)	2.83381609
80	water-soluble vitamin biosynthetic process (GO:0042364)	2.81549269
81	pseudouridine synthesis (GO:0001522)	2.81025832
82	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.79660954
83	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.79660954
84	positive regulation of T cell apoptotic process (GO:0070234)	2.79196849
85	mRNA catabolic process (GO:0006402)	2.78412923
86	ribonucleoprotein complex biogenesis (GO:0022613)	2.77160258
87	UTP metabolic process (GO:0046051)	2.76949339
88	DNA replication checkpoint (GO:0000076)	2.74607261
89	intracellular protein transmembrane import (GO:0044743)	2.74274770
90	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.74078331
91	lung lobe morphogenesis (GO:0060463)	2.71714034
92	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.71511059
93	spinal cord motor neuron differentiation (GO:0021522)	2.68151503
94	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.64458883
95	positive regulation of mRNA catabolic process (GO:0061014)	2.63988097
96	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.63924112
97	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.61455003
98	prenylation (GO:0097354)	2.61358717
99	protein prenylation (GO:0018342)	2.61358717
100	response to pheromone (GO:0019236)	10.4232640

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.22816312
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.13671695
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.10140519
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.06964425
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93203778
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.76770625
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.73339017
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.64648962
9	FUS_26573619_Chip-Seq_HEK293_Human	2.64163608
10	MYC_18940864_ChIP-ChIP_HL60_Human	2.53822925
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.21718365
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.17935373
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.10628965
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.06337079
15	EWS_26573619_Chip-Seq_HEK293_Human	2.00525136
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.00521739
17	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.99914078
18	P300_19829295_ChIP-Seq_ESCs_Human	1.98462494
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.98267202
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.81238140
21	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.79462668
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.78142393
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.75388677
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.73006340
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.72470772
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.71261813
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65543358
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62792492
29	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.60409749
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.60357418
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56244521
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.55161905
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.54429684
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.52373309
35	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.50247037
36	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.49542980
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.48625298
38	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.47521336
39	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.40951005
40	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.39960961
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.37626782
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.37303200
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.36373206
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.35382850
45	GBX2_23144817_ChIP-Seq_PC3_Human	1.33577329
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33355662
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33355662
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32613628
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.31403626
50	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.30608557
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.29812576
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29812576
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.26474593
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26322599
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26322599
56	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.23739112
57	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.22712192
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21950741
59	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.21111985
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19881450
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17861933
62	AR_25329375_ChIP-Seq_VCAP_Human	1.15912606
63	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.15691697
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15641487
65	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.15492593
66	EZH2_22144423_ChIP-Seq_EOC_Human	1.13644867
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13273458
68	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.12188929
69	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.08866192
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07487169
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07048753
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06348370
73	NCOR_22424771_ChIP-Seq_293T_Human	1.04417043
74	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.03920270
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01927230
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01909923
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01639805
78	AR_20517297_ChIP-Seq_VCAP_Human	1.01531203
79	TTF2_22483619_ChIP-Seq_HELA_Human	0.98655601
80	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.96664618
81	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96521687
82	PHF8_20622853_ChIP-Seq_HELA_Human	0.96295822
83	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.96082413
84	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.95045754
85	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.93915874
86	TAF15_26573619_Chip-Seq_HEK293_Human	0.93775934
87	TBL1_22424771_ChIP-Seq_293T_Human	0.93635171
88	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.92407587
89	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.91894545
90	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.91428905
91	RUNX2_22187159_ChIP-Seq_PCA_Human	0.89049407
92	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.88976838
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88779840
94	TCF4_23295773_ChIP-Seq_U87_Human	0.88658846
95	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88498026
96	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.87967534
97	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.87900464
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.87843713
99	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.86581821
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86402717

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	3.99005791
2	MP0008995_early_reproductive_senescence	3.19639038
3	MP0003123_paternal_imprinting	3.14218183
4	MP0003195_calcinosis	3.10643723
5	MP0009379_abnormal_foot_pigmentation	3.05352731
6	MP0002163_abnormal_gland_morphology	2.95779166
7	MP0002102_abnormal_ear_morphology	2.78241688
8	MP0003787_abnormal_imprinting	2.47766250
9	MP0002234_abnormal_pharynx_morphology	2.43441938
10	MP0002282_abnormal_trachea_morphology	2.38022509
11	MP0002132_abnormal_respiratory_system	2.31607174
12	MP0002138_abnormal_hepatobiliary_system	2.22949629
13	MP0002254_reproductive_system_inflammat	2.13316923
14	MP0003121_genomic_imprinting	2.05122149
15	MP0009053_abnormal_anal_canal	2.01087200
16	MP0005379_endocrine/exocrine_gland_phen	1.93096590
17	MP0003880_abnormal_central_pattern	1.84103089
18	MP0010030_abnormal_orbit_morphology	1.83664589
19	MP0000383_abnormal_hair_follicle	1.82542242
20	MP0000516_abnormal_urinary_system	1.78586691
21	MP0005367_renal/urinary_system_phenotyp	1.78586691
22	MP0003786_premature_aging	1.78058065
23	MP0002876_abnormal_thyroid_physiology	1.76878551
24	MP0001293_anophthalmia	1.75563469
25	MP0008875_abnormal_xenobiotic_pharmacok	1.70919715
26	MP0003119_abnormal_digestive_system	1.67171614
27	MP0005647_abnormal_sex_gland	1.64481474
28	MP0002938_white_spotting	1.63856741
29	MP0003950_abnormal_plasma_membrane	1.63327778
30	MP0004133_heterotaxia	1.60240818
31	MP0010678_abnormal_skin_adnexa	1.59897461
32	MP0005084_abnormal_gallbladder_morpholo	1.59001016
33	MP0001879_abnormal_lymphatic_vessel	1.49655844
34	MP0001270_distended_abdomen	1.48357856
35	MP0003136_yellow_coat_color	1.46955588
36	MP0002736_abnormal_nociception_after	1.46212606
37	MP0000631_abnormal_neuroendocrine_gland	1.45973267
38	MP0008058_abnormal_DNA_repair	1.41383919
39	MP0004145_abnormal_muscle_electrophysio	1.35938486
40	MP0008872_abnormal_physiological_respon	1.32477970
41	MP0005551_abnormal_eye_electrophysiolog	1.32383763
42	MP0001986_abnormal_taste_sensitivity	1.30136844
43	MP0003011_delayed_dark_adaptation	1.30006503
44	MP0005645_abnormal_hypothalamus_physiol	1.28256650
45	MP0004142_abnormal_muscle_tone	1.26401409
46	MP0003186_abnormal_redox_activity	1.25559569
47	MP0005646_abnormal_pituitary_gland	1.24978477
48	MP0003937_abnormal_limbs/digits/tail_de	1.24924278
49	MP0003938_abnormal_ear_development	1.23877789
50	MP0001119_abnormal_female_reproductive	1.22065645
51	MP0000049_abnormal_middle_ear	1.21102718
52	MP0009250_abnormal_appendicular_skeleto	1.19974081
53	MP0003122_maternal_imprinting	1.17734194
54	MP0003693_abnormal_embryo_hatching	1.17322594
55	MP0000613_abnormal_salivary_gland	1.16660138
56	MP0003755_abnormal_palate_morphology	1.15834952
57	MP0001299_abnormal_eye_distance/	1.14757925
58	MP0000537_abnormal_urethra_morphology	1.11433505
59	MP0003936_abnormal_reproductive_system	1.11179401
60	MP0005670_abnormal_white_adipose	1.10248876
61	MP0003890_abnormal_embryonic-extraembry	1.08496079
62	MP0005410_abnormal_fertilization	1.08148631
63	MP0009697_abnormal_copulation	1.05016401
64	MP0000678_abnormal_parathyroid_gland	1.03156915
65	MP0002233_abnormal_nose_morphology	1.02632671
66	MP0008877_abnormal_DNA_methylation	1.02550276
67	MP0001984_abnormal_olfaction	1.01109061
68	MP0010368_abnormal_lymphatic_system	1.00730767
69	MP0005174_abnormal_tail_pigmentation	1.00015734
70	MP0000639_abnormal_adrenal_gland	0.98283035
71	MP0001968_abnormal_touch/_nociception	0.97713705
72	MP0000538_abnormal_urinary_bladder	0.95825170
73	MP0000427_abnormal_hair_cycle	0.92192344
74	MP0002139_abnormal_hepatobiliary_system	0.91098790
75	MP0000462_abnormal_digestive_system	0.91091299
76	MP0005389_reproductive_system_phenotype	0.90538412
77	MP0002638_abnormal_pupillary_reflex	0.89725152
78	MP0006292_abnormal_olfactory_placode	0.89634625
79	MP0005195_abnormal_posterior_eye	0.89228239
80	MP0001764_abnormal_homeostasis	0.88057379
81	MP0002210_abnormal_sex_determination	0.87347163
82	MP0003941_abnormal_skin_development	0.85563298
83	MP0003567_abnormal_fetal_cardiomyocyte	0.84739740
84	MP0003315_abnormal_perineum_morphology	0.83477887
85	MP0008775_abnormal_heart_ventricle	0.81456831
86	MP0004215_abnormal_myocardial_fiber	0.79729077
87	MP0002160_abnormal_reproductive_system	0.79469544
88	MP0000372_irregular_coat_pigmentation	0.76973463
89	MP0003646_muscle_fatigue	0.76677041
90	MP0000653_abnormal_sex_gland	0.76056648
91	MP0000778_abnormal_nervous_system	0.75822717
92	MP0000681_abnormal_thyroid_gland	0.75005730
93	MP0001286_abnormal_eye_development	0.74883370
94	MP0002295_abnormal_pulmonary_circulatio	0.74420964
95	MP0001145_abnormal_male_reproductive	0.74017996
96	MP0005253_abnormal_eye_physiology	0.73385490
97	MP0002837_dystrophic_cardiac_calcinosis	0.72633602
98	MP0003935_abnormal_craniofacial_develop	0.72174265
99	MP0004957_abnormal_blastocyst_morpholog	0.71235294
100	MP0002116_abnormal_craniofacial_bone	0.70029494

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal number of erythroid precursors (HP:0012131)	4.52052924
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.38190183
3	Bilateral microphthalmos (HP:0007633)	4.00898547
4	Acute necrotizing encephalopathy (HP:0006965)	3.65784253
5	Pancreatic fibrosis (HP:0100732)	3.45725218
6	Progressive macrocephaly (HP:0004481)	3.45658113
7	Cerebellar dysplasia (HP:0007033)	3.38262953
8	Stenosis of the external auditory canal (HP:0000402)	3.37518288
9	Hypoplasia of the uterus (HP:0000013)	3.31929864
10	Acute encephalopathy (HP:0006846)	3.30236758
11	Colon cancer (HP:0003003)	3.28954178
12	Pancreatic cysts (HP:0001737)	3.25203526
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.21018585
14	True hermaphroditism (HP:0010459)	3.14066680
15	3-Methylglutaconic aciduria (HP:0003535)	3.07698692
16	Thyroid-stimulating hormone excess (HP:0002925)	2.97224001
17	Reticulocytopenia (HP:0001896)	2.91824911
18	Abnormal mitochondria in muscle tissue (HP:0008316)	2.89724091
19	Anophthalmia (HP:0000528)	2.81653372
20	Congenital stationary night blindness (HP:0007642)	2.76434221
21	Mitochondrial inheritance (HP:0001427)	2.72794665
22	Asplenia (HP:0001746)	2.71736297
23	Aplasia/hypoplasia of the uterus (HP:0008684)	2.71555312
24	Increased CSF lactate (HP:0002490)	2.69933259
25	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.67797362
26	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.67700133
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.67399904
28	Double outlet right ventricle (HP:0001719)	2.57527351
29	Congenital malformation of the right heart (HP:0011723)	2.57527351
30	Supernumerary spleens (HP:0009799)	2.54422289
31	Hypoplastic pelvis (HP:0008839)	2.53741433
32	Bifid tongue (HP:0010297)	2.51122697
33	Optic disc pallor (HP:0000543)	2.35696426
34	Hyperglycinemia (HP:0002154)	2.31743515
35	Irregular epiphyses (HP:0010582)	2.29960892
36	Hepatocellular necrosis (HP:0001404)	2.28534226
37	Cerebral edema (HP:0002181)	2.26958286
38	Macrocytic anemia (HP:0001972)	2.26218457
39	Shawl scrotum (HP:0000049)	2.25614183
40	Absent thumb (HP:0009777)	2.25068319
41	Anencephaly (HP:0002323)	2.23076574
42	Type II lissencephaly (HP:0007260)	2.19719483
43	Sensory axonal neuropathy (HP:0003390)	2.17961025
44	Neoplasm of the adrenal cortex (HP:0100641)	2.16460274
45	Molar tooth sign on MRI (HP:0002419)	2.11483097
46	Abnormality of midbrain morphology (HP:0002418)	2.11483097
47	Abnormality of the labia minora (HP:0012880)	2.10462506
48	Sclerocornea (HP:0000647)	2.09819066
49	Abnormality of magnesium homeostasis (HP:0004921)	2.08829803
50	Bicornuate uterus (HP:0000813)	2.02422766
51	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.02269987
52	Genital tract atresia (HP:0001827)	2.00038146
53	Vaginal atresia (HP:0000148)	1.98763048
54	Disproportionate short-trunk short stature (HP:0003521)	1.97714499
55	Cystic liver disease (HP:0006706)	1.95565785
56	Pendular nystagmus (HP:0012043)	1.94970251
57	Abnormality of the pubic bones (HP:0003172)	1.94234107
58	Abnormal pancreas size (HP:0012094)	1.91206419
59	Amblyopia (HP:0000646)	1.91107530
60	Small hand (HP:0200055)	1.90807935
61	Triphalangeal thumb (HP:0001199)	1.90768574
62	Postaxial foot polydactyly (HP:0001830)	1.90203294
63	Gout (HP:0001997)	1.89105667
64	Lipid accumulation in hepatocytes (HP:0006561)	1.87565120
65	Lissencephaly (HP:0001339)	1.87510781
66	Nephronophthisis (HP:0000090)	1.86918911
67	Hyperglycinuria (HP:0003108)	1.86637980
68	Hyperventilation (HP:0002883)	1.86020244
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85986080
70	Oligodactyly (hands) (HP:0001180)	1.85847296
71	Maternal diabetes (HP:0009800)	1.85431826
72	Type 2 muscle fiber atrophy (HP:0003554)	1.84365190
73	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.84340134
74	Male pseudohermaphroditism (HP:0000037)	1.84064818
75	Increased hepatocellular lipid droplets (HP:0006565)	1.83819575
76	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.83701323
77	Hepatic necrosis (HP:0002605)	1.82873286
78	Abnormal respiratory motile cilium physiology (HP:0012261)	1.82336262
79	Abnormal lung lobation (HP:0002101)	1.81853034
80	Abnormal drinking behavior (HP:0030082)	1.81422448
81	Polydipsia (HP:0001959)	1.81422448
82	Hypoplastic iliac wings (HP:0002866)	1.77629699
83	Metabolic alkalosis (HP:0200114)	1.77160054
84	Increased corneal curvature (HP:0100692)	1.76340129
85	Keratoconus (HP:0000563)	1.76340129
86	Hypomagnesemia (HP:0002917)	1.75873513
87	Respiratory failure (HP:0002878)	1.73038684
88	Vitreoretinal degeneration (HP:0000655)	1.72531834
89	Intestinal atresia (HP:0011100)	1.72189248
90	Medial flaring of the eyebrow (HP:0010747)	1.71891375
91	Hypochromic microcytic anemia (HP:0004840)	1.71441435
92	Preaxial hand polydactyly (HP:0001177)	1.69649141
93	Renal hypoplasia (HP:0000089)	1.69421039
94	Polyuria (HP:0000103)	1.67671434
95	Hydronephrosis (HP:0000126)	1.67265089
96	Tubular atrophy (HP:0000092)	1.66759360
97	Cleft eyelid (HP:0000625)	1.66613213
98	Lethargy (HP:0001254)	1.65983228
99	Constricted visual fields (HP:0001133)	1.65320979
100	Severe visual impairment (HP:0001141)	1.65262638

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	5.26452113
2	EPHA4	4.06553512
3	FRK	4.05760144
4	TNIK	3.68693636
5	EIF2AK1	3.56149784
6	MUSK	3.54515043
7	ZAK	2.56775105
8	WNK4	2.49198100
9	MAP4K2	2.41489502
10	FGFR2	2.06888921
11	GRK1	2.04878333
12	EIF2AK3	1.99293185
13	NUAK1	1.81486786
14	TRIM28	1.73774814
15	MAPKAPK5	1.71603866
16	AKT3	1.63383312
17	DYRK2	1.60476384
18	EEF2K	1.46127209
19	VRK2	1.44307534
20	CASK	1.37040405
21	BCR	1.36252365
22	MAPKAPK3	1.34302677
23	BMPR1B	1.26676612
24	BCKDK	1.26303906
25	MAPK13	1.23724931
26	STK39	1.21817170
27	ACVR1B	1.16128307
28	SRPK1	1.15455032
29	ADRBK2	1.09911656
30	ERBB3	1.06106353
31	RPS6KB2	1.00683289
32	DAPK2	0.99881870
33	OXSR1	0.99093272
34	ADRBK1	0.97534052
35	PINK1	0.97528364
36	LRRK2	0.94922511
37	DYRK3	0.91108332
38	EPHB2	0.90203654
39	PNCK	0.89670107
40	PLK3	0.89403674
41	PRKD3	0.87616870
42	CAMKK2	0.87615689
43	TAF1	0.86367072
44	MST4	0.83911456
45	NTRK3	0.82891133
46	TLK1	0.78129292
47	MAP3K9	0.77647174
48	PAK3	0.70895577
49	PRKCI	0.68818617
50	PLK2	0.66120502
51	EIF2AK2	0.62357731
52	VRK1	0.61737964
53	STK11	0.60720106
54	NEK1	0.59510932
55	INSRR	0.58746161
56	CAMK1	0.58614615
57	PRKCE	0.58579558
58	MKNK2	0.56367269
59	WNK3	0.54795924
60	ABL2	0.54191896
61	MAP3K11	0.54108969
62	BRSK1	0.52681477
63	STK3	0.50840599
64	MARK1	0.50741402
65	CHEK2	0.50184941
66	BRSK2	0.48666756
67	LATS1	0.48560381
68	PDK2	0.48438536
69	NME2	0.47314778
70	MELK	0.44652223
71	PRKCG	0.44458788
72	SIK2	0.42556673
73	MKNK1	0.40512653
74	WEE1	0.39722913
75	TRPM7	0.39533229
76	CSNK2A2	0.39499615
77	TGFBR1	0.39308393
78	STK4	0.38184720
79	RPS6KA4	0.36999887
80	RPS6KA5	0.36207985
81	MAPK15	0.35855815
82	CAMK1D	0.35230904
83	CSNK1G2	0.35186424
84	MAPK11	0.34781448
85	STK38L	0.34431548
86	PRKG2	0.33806115
87	BUB1	0.31068326
88	PLK4	0.31021160
89	CSNK1A1	0.30744029
90	CAMK1G	0.30619912
91	PHKG1	0.30613989
92	PHKG2	0.30613989
93	CSNK1E	0.29464639
94	DAPK3	0.28243092
95	PRKACA	0.27383160
96	CSNK1G3	0.27133805
97	CSNK2A1	0.26632250
98	MAP3K12	0.26609925
99	ATM	0.25625263
100	PIK3CA	0.22656802

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.43946840
2	Caffeine metabolism_Homo sapiens_hsa00232	3.72043806
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.60491147
4	Parkinsons disease_Homo sapiens_hsa05012	3.11311101
5	RNA polymerase_Homo sapiens_hsa03020	3.00218062
6	Protein export_Homo sapiens_hsa03060	2.55898600
7	Huntingtons disease_Homo sapiens_hsa05016	2.42770955
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.18963839
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.15999827
10	Alzheimers disease_Homo sapiens_hsa05010	1.91438421
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89041970
12	Mismatch repair_Homo sapiens_hsa03430	1.88587056
13	Homologous recombination_Homo sapiens_hsa03440	1.85791083
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.82630309
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.74576276
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74378516
17	Basal transcription factors_Homo sapiens_hsa03022	1.70227715
18	Propanoate metabolism_Homo sapiens_hsa00640	1.59481719
19	RNA degradation_Homo sapiens_hsa03018	1.56588387
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.56184075
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.53437611
22	Proteasome_Homo sapiens_hsa03050	1.52711378
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.49802199
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.49286993
25	Olfactory transduction_Homo sapiens_hsa04740	1.42940027
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.42727289
27	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.41514814
28	One carbon pool by folate_Homo sapiens_hsa00670	1.40027156
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.39744923
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.34206170
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.29635691
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.28441308
33	Peroxisome_Homo sapiens_hsa04146	1.25254281
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.22545395
35	Butanoate metabolism_Homo sapiens_hsa00650	1.18366308
36	Phototransduction_Homo sapiens_hsa04744	1.14712834
37	Basal cell carcinoma_Homo sapiens_hsa05217	1.14502069
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.14131577
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.11047602
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10591895
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.10120199
42	Base excision repair_Homo sapiens_hsa03410	1.07049070
43	Fat digestion and absorption_Homo sapiens_hsa04975	1.06299440
44	Mineral absorption_Homo sapiens_hsa04978	0.96813921
45	Retinol metabolism_Homo sapiens_hsa00830	0.95982497
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.95845256
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.92315366
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90240351
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90082592
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.88874121
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88289427
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87659891
53	Sulfur metabolism_Homo sapiens_hsa00920	0.87614397
54	Purine metabolism_Homo sapiens_hsa00230	0.87100562
55	DNA replication_Homo sapiens_hsa03030	0.85488134
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.84649198
57	Metabolic pathways_Homo sapiens_hsa01100	0.82706203
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82249608
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81799061
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.79509555
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76432140
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.75946233
63	Wnt signaling pathway_Homo sapiens_hsa04310	0.70210643
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68039322
65	RNA transport_Homo sapiens_hsa03013	0.67055235
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.64771944
67	Fatty acid degradation_Homo sapiens_hsa00071	0.63973081
68	Sulfur relay system_Homo sapiens_hsa04122	0.61043540
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60865314
70	Tryptophan metabolism_Homo sapiens_hsa00380	0.55238591
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53424932
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52681490
73	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.52211978
74	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.51334760
75	Pyruvate metabolism_Homo sapiens_hsa00620	0.51162961
76	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.50969136
77	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.48828119
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48354069
79	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.46492777
80	Circadian rhythm_Homo sapiens_hsa04710	0.46446524
81	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.46017969
82	Spliceosome_Homo sapiens_hsa03040	0.43865660
83	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.43292533
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.42960106
85	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42574969
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.39950560
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.36759111
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36401328
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35723842
90	Glutathione metabolism_Homo sapiens_hsa00480	0.29688414
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29248670
92	Histidine metabolism_Homo sapiens_hsa00340	0.27988216
93	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.27376808
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.26747220
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.26212748
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.20561988
97	PPAR signaling pathway_Homo sapiens_hsa03320	0.20477774
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.19869249
99	Salivary secretion_Homo sapiens_hsa04970	0.19539376
100	Taste transduction_Homo sapiens_hsa04742	0.18012883

RPL22P18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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