ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	8.84976151
2	ribosomal small subunit assembly (GO:0000028)	7.83624088
3	ribosomal small subunit biogenesis (GO:0042274)	7.67028462
4	viral transcription (GO:0019083)	6.82491607
5	translational termination (GO:0006415)	6.67675603
6	negative regulation of B cell apoptotic process (GO:0002903)	6.31411688
7	chaperone-mediated protein transport (GO:0072321)	5.59549273
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.53365853
9	translational elongation (GO:0006414)	5.53207297
10	protein targeting to ER (GO:0045047)	5.45820906
11	cotranslational protein targeting to membrane (GO:0006613)	5.44991842
12	behavioral response to nicotine (GO:0035095)	5.36431434
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.34238869
14	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	5.15534061
15	viral life cycle (GO:0019058)	5.11876150
16	protein localization to endoplasmic reticulum (GO:0070972)	5.08173340
17	cellular protein complex disassembly (GO:0043624)	4.93140076
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.87428996
19	termination of RNA polymerase III transcription (GO:0006386)	4.63794248
20	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.63794248
21	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.48592616
22	translational initiation (GO:0006413)	4.29375229
23	ribonucleoprotein complex biogenesis (GO:0022613)	4.27008264
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.21311594
25	protein complex disassembly (GO:0043241)	4.10543412
26	nonmotile primary cilium assembly (GO:0035058)	3.99918304
27	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.95061886
28	macromolecular complex disassembly (GO:0032984)	3.92343335
29	ribosomal large subunit biogenesis (GO:0042273)	3.89257320
30	regulation of regulatory T cell differentiation (GO:0045589)	3.88289093
31	ncRNA 3-end processing (GO:0043628)	3.85812227
32	translation (GO:0006412)	3.81282750
33	ATP synthesis coupled proton transport (GO:0015986)	3.80428458
34	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.80428458
35	pseudouridine synthesis (GO:0001522)	3.69105134
36	cellular component biogenesis (GO:0044085)	3.68951033
37	interferon-gamma production (GO:0032609)	3.66171939
38	protein targeting to membrane (GO:0006612)	3.65655436
39	regulation of B cell apoptotic process (GO:0002902)	3.61461705
40	somite development (GO:0061053)	3.60450326
41	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.60290398
42	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.51644765
43	pyrimidine nucleotide catabolic process (GO:0006244)	3.47799016
44	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.35275000
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.34102691
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.34102691
47	NADH dehydrogenase complex assembly (GO:0010257)	3.34102691
48	mRNA catabolic process (GO:0006402)	3.32750210
49	regulation of isotype switching to IgG isotypes (GO:0048302)	3.31713546
50	ribosome biogenesis (GO:0042254)	3.29209865
51	sulfate transport (GO:0008272)	3.23135655
52	cardiovascular system development (GO:0072358)	3.22414712
53	sulfate transmembrane transport (GO:1902358)	3.17208810
54	regulation of memory T cell differentiation (GO:0043380)	3.15777217
55	rRNA processing (GO:0006364)	3.14537319
56	peptidyl-histidine modification (GO:0018202)	3.12393035
57	positive regulation of T cell apoptotic process (GO:0070234)	3.11645761
58	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.11435432
59	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.11435432
60	protein complex biogenesis (GO:0070271)	3.09321900
61	regulation of immunoglobulin secretion (GO:0051023)	3.05828995
62	regulation of telomerase activity (GO:0051972)	3.05054435
63	protein neddylation (GO:0045116)	3.04339042
64	respiratory electron transport chain (GO:0022904)	3.04094779
65	rRNA metabolic process (GO:0016072)	3.02617545
66	kidney morphogenesis (GO:0060993)	3.02200510
67	transcription from RNA polymerase III promoter (GO:0006383)	3.01169510
68	electron transport chain (GO:0022900)	3.00959595
69	RNA catabolic process (GO:0006401)	3.00136455
70	positive regulation of meiosis (GO:0045836)	2.96470111
71	mitochondrial respiratory chain complex assembly (GO:0033108)	2.95244434
72	protein targeting to mitochondrion (GO:0006626)	2.94821262
73	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.94147477
74	protein-cofactor linkage (GO:0018065)	2.92332665
75	establishment of protein localization to mitochondrion (GO:0072655)	2.85484944
76	lung morphogenesis (GO:0060425)	2.85249590
77	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.81864701
78	positive regulation of meiotic cell cycle (GO:0051446)	2.75828841
79	positive regulation of interleukin-17 production (GO:0032740)	2.73602809
80	tRNA processing (GO:0008033)	2.71865008
81	protein localization to mitochondrion (GO:0070585)	2.71849987
82	GTP biosynthetic process (GO:0006183)	2.69791824
83	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.67459019
84	lung-associated mesenchyme development (GO:0060484)	2.67244485
85	regulation of meiosis I (GO:0060631)	2.67093253
86	peptidyl-threonine dephosphorylation (GO:0035970)	2.61487412
87	protein targeting (GO:0006605)	2.61162137
88	establishment of protein localization to membrane (GO:0090150)	2.58806525
89	urate metabolic process (GO:0046415)	2.56344629
90	kynurenine metabolic process (GO:0070189)	2.55925934
91	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.53420607
92	synaptic transmission, cholinergic (GO:0007271)	2.53296583
93	ubiquinone biosynthetic process (GO:0006744)	2.53249084
94	base-excision repair, AP site formation (GO:0006285)	2.52717518
95	regulation of cellular respiration (GO:0043457)	2.52019723
96	respiratory tube development (GO:0030323)	2.51995023
97	regulation of mitochondrial translation (GO:0070129)	2.51787266
98	preassembly of GPI anchor in ER membrane (GO:0016254)	2.50519014
99	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.50509799
100	spinal cord association neuron differentiation (GO:0021527)	2.48126993

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.45707833
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.68084899
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.58602205
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.43468235
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.25270573
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.01578161
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.93941418
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.88298455
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.85590686
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.77375786
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.70929940
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.63049569
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.51884425
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37893277
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.33155052
16	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.13331333
17	XRN2_22483619_ChIP-Seq_HELA_Human	2.04082409
18	VDR_22108803_ChIP-Seq_LS180_Human	2.03382671
19	TTF2_22483619_ChIP-Seq_HELA_Human	2.01117721
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.95354850
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.79843703
22	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.71626531
23	CIITA_25753668_ChIP-Seq_RAJI_Human	1.70756094
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.67169604
25	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.65442942
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.65391136
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.65259288
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.64636719
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.59961444
30	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.59835089
31	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.55671458
32	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.54363551
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51863999
34	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.47224944
35	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.46839863
36	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.44834275
37	GABP_19822575_ChIP-Seq_HepG2_Human	1.43680633
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43005866
39	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.42490923
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41496687
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.39378753
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35638498
43	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.35395130
44	EWS_26573619_Chip-Seq_HEK293_Human	1.34359555
45	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.33290049
46	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32563913
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.30490498
48	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.29966089
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29258076
50	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.26276515
51	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.21555390
52	TAF2_19829295_ChIP-Seq_ESCs_Human	1.21362283
53	ERA_21632823_ChIP-Seq_H3396_Human	1.20562156
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.20449954
55	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.18607339
56	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.17549553
57	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.15934227
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12223342
59	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.11559607
60	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.10246009
61	BCL6_27268052_Chip-Seq_Bcells_Human	1.10019855
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.09775889
63	P68_20966046_ChIP-Seq_HELA_Human	1.07422235
64	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.07266104
65	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.07182850
66	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.06714250
67	STAT1_20625510_ChIP-Seq_HELA_Human	1.05226871
68	DCP1A_22483619_ChIP-Seq_HELA_Human	1.04157052
69	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.03513838
70	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.03260400
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01701895
72	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.01608877
73	IGF1R_20145208_ChIP-Seq_DFB_Human	1.01452774
74	E2F1_20622854_ChIP-Seq_HELA_Human	1.00610428
75	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00513204
76	CTCF_20526341_ChIP-Seq_ESCs_Human	0.99544272
77	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.99409086
78	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.98101541
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97129788
80	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.97080420
81	MYC_19829295_ChIP-Seq_ESCs_Human	0.96074257
82	KDM5A_27292631_Chip-Seq_BREAST_Human	0.95737470
83	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94817372
84	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.93828938
85	NCOR_22424771_ChIP-Seq_293T_Human	0.93192813
86	FUS_26573619_Chip-Seq_HEK293_Human	0.92127915
87	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92030091
88	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.91549071
89	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.89849640
90	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.88976125
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.88436805
92	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.88294984
93	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.87721264
94	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.87351829
95	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.86536999
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.85144333
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.85143984
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.84918515
99	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.84074051
100	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.84058531

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.74111493
2	MP0006292_abnormal_olfactory_placode	4.50653564
3	MP0002138_abnormal_hepatobiliary_system	4.07572759
4	MP0001853_heart_inflammation	2.88203266
5	MP0005646_abnormal_pituitary_gland	2.87612706
6	MP0003646_muscle_fatigue	2.80352883
7	MP0002837_dystrophic_cardiac_calcinosis	2.75715171
8	MP0002234_abnormal_pharynx_morphology	2.71425500
9	MP0002653_abnormal_ependyma_morphology	2.56458069
10	MP0002638_abnormal_pupillary_reflex	2.56197906
11	MP0004147_increased_porphyrin_level	2.44172941
12	MP0010030_abnormal_orbit_morphology	2.24492974
13	MP0008789_abnormal_olfactory_epithelium	2.23983482
14	MP0003693_abnormal_embryo_hatching	2.08934065
15	MP0006276_abnormal_autonomic_nervous	2.03004295
16	MP0005645_abnormal_hypothalamus_physiol	2.02737237
17	MP0004145_abnormal_muscle_electrophysio	2.01821288
18	MP0003786_premature_aging	1.95227801
19	MP0000678_abnormal_parathyroid_gland	1.87871976
20	MP0005360_urolithiasis	1.86683517
21	MP0000049_abnormal_middle_ear	1.83857938
22	MP0000465_gastrointestinal_hemorrhage	1.83219544
23	MP0008058_abnormal_DNA_repair	1.77166032
24	MP0003787_abnormal_imprinting	1.75683987
25	MP0005075_abnormal_melanosome_morpholog	1.74870278
26	MP0008875_abnormal_xenobiotic_pharmacok	1.63809868
27	MP0002163_abnormal_gland_morphology	1.63159138
28	MP0004858_abnormal_nervous_system	1.61229751
29	MP0002938_white_spotting	1.56415046
30	MP0002102_abnormal_ear_morphology	1.52636430
31	MP0008995_early_reproductive_senescence	1.50023233
32	MP0005499_abnormal_olfactory_system	1.45945529
33	MP0005394_taste/olfaction_phenotype	1.45945529
34	MP0004381_abnormal_hair_follicle	1.43623595
35	MP0004142_abnormal_muscle_tone	1.42506474
36	MP0005551_abnormal_eye_electrophysiolog	1.38067320
37	MP0000778_abnormal_nervous_system	1.37954898
38	MP0000631_abnormal_neuroendocrine_gland	1.31121716
39	MP0001293_anophthalmia	1.26110800
40	MP0001485_abnormal_pinna_reflex	1.21891943
41	MP0001905_abnormal_dopamine_level	1.21276968
42	MP0008877_abnormal_DNA_methylation	1.20656972
43	MP0002210_abnormal_sex_determination	1.20450026
44	MP0006072_abnormal_retinal_apoptosis	1.19615818
45	MP0002736_abnormal_nociception_after	1.15867943
46	MP0001835_abnormal_antigen_presentation	1.09787887
47	MP0002095_abnormal_skin_pigmentation	1.09358751
48	MP0008872_abnormal_physiological_respon	1.08284405
49	MP0006036_abnormal_mitochondrial_physio	1.06876886
50	MP0001502_abnormal_circadian_rhythm	1.06537958
51	MP0005195_abnormal_posterior_eye	1.06242112
52	MP0001968_abnormal_touch/_nociception	1.03709507
53	MP0009745_abnormal_behavioral_response	1.00372552
54	MP0003195_calcinosis	0.98997563
55	MP0005389_reproductive_system_phenotype	0.96672073
56	MP0002160_abnormal_reproductive_system	0.95995114
57	MP0002272_abnormal_nervous_system	0.94337953
58	MP0005410_abnormal_fertilization	0.93831046
59	MP0008057_abnormal_DNA_replication	0.93547212
60	MP0001929_abnormal_gametogenesis	0.93313983
61	MP0002733_abnormal_thermal_nociception	0.92111633
62	MP0003890_abnormal_embryonic-extraembry	0.91663428
63	MP0009278_abnormal_bone_marrow	0.90449263
64	MP0003119_abnormal_digestive_system	0.90178654
65	MP0005174_abnormal_tail_pigmentation	0.88917535
66	MP0003698_abnormal_male_reproductive	0.88886429
67	MP0001919_abnormal_reproductive_system	0.88100913
68	MP0003879_abnormal_hair_cell	0.87986431
69	MP0003938_abnormal_ear_development	0.87180922
70	MP0000653_abnormal_sex_gland	0.86720414
71	MP0002557_abnormal_social/conspecific_i	0.82691041
72	MP0003300_gastrointestinal_ulcer	0.82637395
73	MP0001145_abnormal_male_reproductive	0.82324097
74	MP0001727_abnormal_embryo_implantation	0.81636965
75	MP0001970_abnormal_pain_threshold	0.81237070
76	MP0000604_amyloidosis	0.79578980
77	MP0005253_abnormal_eye_physiology	0.78098720
78	MP0005391_vision/eye_phenotype	0.77394415
79	MP0004742_abnormal_vestibular_system	0.77127752
80	MP0004130_abnormal_muscle_cell	0.77065530
81	MP0002277_abnormal_respiratory_mucosa	0.75909275
82	MP0002752_abnormal_somatic_nervous	0.74890179
83	MP0003123_paternal_imprinting	0.74623687
84	MP0001542_abnormal_bone_strength	0.74246339
85	MP0000026_abnormal_inner_ear	0.74210968
86	MP0003718_maternal_effect	0.73741090
87	MP0009046_muscle_twitch	0.72056235
88	MP0008775_abnormal_heart_ventricle	0.71936762
89	MP0005671_abnormal_response_to	0.70689577
90	MP0003936_abnormal_reproductive_system	0.70215432
91	MP0000955_abnormal_spinal_cord	0.69371655
92	MP0001119_abnormal_female_reproductive	0.68061849
93	MP0005084_abnormal_gallbladder_morpholo	0.66862253
94	MP0002064_seizures	0.66063564
95	MP0001286_abnormal_eye_development	0.63751927
96	MP0002184_abnormal_innervation	0.63534757
97	MP0003635_abnormal_synaptic_transmissio	0.63365224
98	MP0003122_maternal_imprinting	0.62155436
99	MP0002928_abnormal_bile_duct	0.60962748
100	MP0000647_abnormal_sebaceous_gland	0.60224193

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Elevated erythrocyte sedimentation rate (HP:0003565)	5.23075035
2	Reticulocytopenia (HP:0001896)	5.12320148
3	Pancreatic fibrosis (HP:0100732)	4.53155631
4	Abnormality of cells of the erythroid lineage (HP:0012130)	4.38614329
5	Acute necrotizing encephalopathy (HP:0006965)	4.26134880
6	Abnormality of midbrain morphology (HP:0002418)	4.24613681
7	Molar tooth sign on MRI (HP:0002419)	4.24613681
8	True hermaphroditism (HP:0010459)	4.09691937
9	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.92599909
10	Abnormality of alanine metabolism (HP:0010916)	3.80716763
11	Hyperalaninemia (HP:0003348)	3.80716763
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.80716763
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.69691366
14	Pancreatic cysts (HP:0001737)	3.66821047
15	Acute encephalopathy (HP:0006846)	3.56163529
16	Macrocytic anemia (HP:0001972)	3.45395412
17	3-Methylglutaconic aciduria (HP:0003535)	3.42760950
18	Progressive macrocephaly (HP:0004481)	3.39224068
19	Absent thumb (HP:0009777)	3.24904691
20	Abnormal number of erythroid precursors (HP:0012131)	3.23910801
21	Mitochondrial inheritance (HP:0001427)	3.13522513
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.05463915
23	Increased CSF lactate (HP:0002490)	3.01419219
24	Anencephaly (HP:0002323)	2.98858147
25	Pallor (HP:0000980)	2.95265030
26	Congenital stationary night blindness (HP:0007642)	2.85435003
27	Nephronophthisis (HP:0000090)	2.84980100
28	Colon cancer (HP:0003003)	2.84002338
29	Medial flaring of the eyebrow (HP:0010747)	2.78141792
30	Type II lissencephaly (HP:0007260)	2.73079388
31	Cystic liver disease (HP:0006706)	2.67827691
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.52678196
33	Hyperthyroidism (HP:0000836)	2.50573902
34	Hyperglycinemia (HP:0002154)	2.47904676
35	Myokymia (HP:0002411)	2.46525190
36	Agitation (HP:0000713)	2.45777859
37	Cerebral edema (HP:0002181)	2.44940922
38	Abnormal hemoglobin (HP:0011902)	2.43181430
39	Microretrognathia (HP:0000308)	2.42298143
40	Sclerocornea (HP:0000647)	2.37790726
41	Increased intramyocellular lipid droplets (HP:0012240)	2.36938388
42	Gait imbalance (HP:0002141)	2.30925343
43	Increased hepatocellular lipid droplets (HP:0006565)	2.30721507
44	Congenital primary aphakia (HP:0007707)	2.27185898
45	Abnormality of the renal medulla (HP:0100957)	2.26421474
46	Increased serum lactate (HP:0002151)	2.22948081
47	Optic disc pallor (HP:0000543)	2.19370475
48	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.19210126
49	Postaxial foot polydactyly (HP:0001830)	2.19029824
50	Pendular nystagmus (HP:0012043)	2.18917922
51	Occipital encephalocele (HP:0002085)	2.17545885
52	Hepatocellular necrosis (HP:0001404)	2.14814416
53	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.09490756
54	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.09490756
55	Lipid accumulation in hepatocytes (HP:0006561)	2.08223698
56	Hypoplasia of the radius (HP:0002984)	2.06326605
57	Depressed nasal ridge (HP:0000457)	2.05745956
58	Cerebellar dysplasia (HP:0007033)	2.05639301
59	Chorioretinal atrophy (HP:0000533)	2.04742747
60	Abolished electroretinogram (ERG) (HP:0000550)	2.03048147
61	Ileus (HP:0002595)	1.99673545
62	Stenosis of the external auditory canal (HP:0000402)	1.98497216
63	Nephrogenic diabetes insipidus (HP:0009806)	1.98359538
64	Constricted visual fields (HP:0001133)	1.97067794
65	Holoprosencephaly (HP:0001360)	1.96985258
66	Keratoconus (HP:0000563)	1.95444555
67	Increased corneal curvature (HP:0100692)	1.95444555
68	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.92125990
69	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.92125990
70	Lethargy (HP:0001254)	1.91167142
71	Increased muscle lipid content (HP:0009058)	1.90343112
72	Abnormality of serum amino acid levels (HP:0003112)	1.87346794
73	Reduced subcutaneous adipose tissue (HP:0003758)	1.87262705
74	Furrowed tongue (HP:0000221)	1.84961201
75	Poor coordination (HP:0002370)	1.84955972
76	Male pseudohermaphroditism (HP:0000037)	1.84186810
77	Abnormality of the fingertips (HP:0001211)	1.84182313
78	Lactic acidosis (HP:0003128)	1.83734212
79	Decreased central vision (HP:0007663)	1.83699795
80	Forearm undergrowth (HP:0009821)	1.82528976
81	Large eyes (HP:0001090)	1.78855373
82	Chronic hepatic failure (HP:0100626)	1.77333537
83	Restlessness (HP:0000711)	1.75706039
84	Respiratory failure (HP:0002878)	1.75373641
85	Hepatic necrosis (HP:0002605)	1.74298164
86	Chronic sinusitis (HP:0011109)	1.72353958
87	Maternal diabetes (HP:0009800)	1.70680188
88	Cleft eyelid (HP:0000625)	1.70307370
89	Hypoplasia of the ulna (HP:0003022)	1.70181876
90	Leukodystrophy (HP:0002415)	1.69504380
91	Adrenal hypoplasia (HP:0000835)	1.69436073
92	Focal motor seizures (HP:0011153)	1.68234107
93	Methylmalonic acidemia (HP:0002912)	1.67875230
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.66523414
95	Asplenia (HP:0001746)	1.66141697
96	Anterior segment dysgenesis (HP:0007700)	1.65718019
97	Narrow forehead (HP:0000341)	1.64240306
98	Abnormality of cochlea (HP:0000375)	1.63197565
99	Exertional dyspnea (HP:0002875)	1.61214503
100	Chronic otitis media (HP:0000389)	1.60271313

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	2.90142973
2	ADRBK2	2.74934011
3	SIK2	2.72563881
4	FRK	2.50303469
5	WNK4	2.45935752
6	TLK1	2.42061701
7	DYRK2	2.36374619
8	ZAK	2.29027559
9	PDK2	2.26762688
10	NME2	2.23954166
11	MAP4K2	2.06654637
12	VRK2	2.04005735
13	PINK1	2.00003538
14	NUAK1	1.94900727
15	BCKDK	1.89855445
16	GRK1	1.83150953
17	STK16	1.81598950
18	TEC	1.79764156
19	CAMKK2	1.58236581
20	LRRK2	1.56731833
21	VRK1	1.50722080
22	CDK19	1.48748983
23	CSNK1G3	1.48477463
24	MARK3	1.42384571
25	EPHA3	1.34937739
26	TNIK	1.33941092
27	CSNK1G1	1.32985224
28	ATR	1.30649227
29	ICK	1.29387742
30	ACVR1B	1.28780302
31	NLK	1.21471080
32	TAF1	1.19390784
33	CDC7	1.18983858
34	CSNK1G2	1.18318811
35	CAMK1D	1.17970419
36	CAMK1	1.15339139
37	AURKB	1.12061494
38	STK39	1.10941603
39	DYRK3	1.10248256
40	PIK3CA	1.06719179
41	IRAK1	1.03941242
42	SRPK1	1.02340162
43	PAK3	1.00510710
44	MST4	1.00386230
45	PLK4	0.98276522
46	CASK	0.97640213
47	NME1	0.96907059
48	AURKA	0.95277426
49	ADRBK1	0.94041097
50	CSNK1A1L	0.93998207
51	BMPR1B	0.93182336
52	TYRO3	0.92460130
53	IKBKB	0.90894086
54	SIK3	0.87807821
55	ABL2	0.85708666
56	INSRR	0.85417565
57	OXSR1	0.84340043
58	CSNK2A2	0.83168937
59	MARK1	0.81374048
60	RPS6KA5	0.81224966
61	NEK1	0.79284376
62	MINK1	0.78854263
63	DYRK1B	0.77961993
64	PLK1	0.76767430
65	ITK	0.75728107
66	MKNK2	0.74570887
67	PKN1	0.71405465
68	STK11	0.71030446
69	MAP3K11	0.70815283
70	CAMK1G	0.70118270
71	CSNK1E	0.69478755
72	PRKCZ	0.69329415
73	MAP3K9	0.68780508
74	CSNK2A1	0.67915023
75	BUB1	0.67499114
76	TIE1	0.67392004
77	PRKAA1	0.66633615
78	CHUK	0.64464674
79	SIK1	0.64442617
80	NTRK2	0.62906305
81	CHEK2	0.62176641
82	WNK3	0.60156747
83	PAK1	0.58834645
84	ATM	0.57231112
85	PAK6	0.55777058
86	PRKCG	0.55186160
87	WNK1	0.55043237
88	ALK	0.54589702
89	PRKACA	0.54482573
90	EPHB2	0.54091323
91	KSR1	0.53723346
92	MAPK13	0.49786523
93	PRKD3	0.47873735
94	CAMKK1	0.47331320
95	MAP3K5	0.46961257
96	PRKCI	0.46530943
97	MAP3K13	0.45617428
98	DAPK3	0.45602262
99	GRK5	0.45105740
100	STK4	0.45025127

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.02804400
2	RNA polymerase_Homo sapiens_hsa03020	3.54086502
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.25838276
4	Parkinsons disease_Homo sapiens_hsa05012	2.93202047
5	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.66522977
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.44484195
7	Huntingtons disease_Homo sapiens_hsa05016	2.35490588
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.23912647
9	One carbon pool by folate_Homo sapiens_hsa00670	2.23725212
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18141724
11	Proteasome_Homo sapiens_hsa03050	2.07826010
12	Pyrimidine metabolism_Homo sapiens_hsa00240	1.86500590
13	Basal transcription factors_Homo sapiens_hsa03022	1.80576032
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.78569787
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.74961491
16	Alzheimers disease_Homo sapiens_hsa05010	1.73770072
17	Protein export_Homo sapiens_hsa03060	1.71329713
18	Alcoholism_Homo sapiens_hsa05034	1.66815668
19	DNA replication_Homo sapiens_hsa03030	1.62972397
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.54724810
21	Phototransduction_Homo sapiens_hsa04744	1.53953218
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.50853747
23	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.49338507
24	Homologous recombination_Homo sapiens_hsa03440	1.45404402
25	Mismatch repair_Homo sapiens_hsa03430	1.44334001
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29911718
27	Allograft rejection_Homo sapiens_hsa05330	1.28355218
28	RNA degradation_Homo sapiens_hsa03018	1.23840741
29	Base excision repair_Homo sapiens_hsa03410	1.21414213
30	Purine metabolism_Homo sapiens_hsa00230	1.17121977
31	Graft-versus-host disease_Homo sapiens_hsa05332	1.14514208
32	Asthma_Homo sapiens_hsa05310	1.12868914
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.11101795
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.10633492
35	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.09185754
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.08568219
37	Arginine and proline metabolism_Homo sapiens_hsa00330	1.07520852
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.07479511
39	Propanoate metabolism_Homo sapiens_hsa00640	1.03441347
40	RNA transport_Homo sapiens_hsa03013	1.02400473
41	Butanoate metabolism_Homo sapiens_hsa00650	1.02159632
42	Olfactory transduction_Homo sapiens_hsa04740	1.02001257
43	Sulfur relay system_Homo sapiens_hsa04122	1.01919606
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96994878
45	Fatty acid elongation_Homo sapiens_hsa00062	0.94776441
46	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.94342003
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.93497567
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.93479555
49	Spliceosome_Homo sapiens_hsa03040	0.92956291
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.89804836
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.87713964
52	Basal cell carcinoma_Homo sapiens_hsa05217	0.85034365
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80551928
54	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.80179391
55	Nicotine addiction_Homo sapiens_hsa05033	0.80022431
56	Taste transduction_Homo sapiens_hsa04742	0.78452847
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.74876431
58	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.70518176
59	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.69325422
60	p53 signaling pathway_Homo sapiens_hsa04115	0.68526331
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68247609
62	Peroxisome_Homo sapiens_hsa04146	0.68201471
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66844267
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.65557568
65	Retinol metabolism_Homo sapiens_hsa00830	0.63454042
66	Metabolic pathways_Homo sapiens_hsa01100	0.57438936
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.56933396
68	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.56710159
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.55619634
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55384499
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55112004
72	Fatty acid degradation_Homo sapiens_hsa00071	0.54647505
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.49282915
74	Viral carcinogenesis_Homo sapiens_hsa05203	0.48607039
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46641917
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46255616
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46196101
78	Caffeine metabolism_Homo sapiens_hsa00232	0.44281044
79	Morphine addiction_Homo sapiens_hsa05032	0.42890660
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.42657590
81	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.42358687
82	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.41583720
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41570872
84	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.41547504
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40409705
86	Insulin secretion_Homo sapiens_hsa04911	0.39993598
87	Serotonergic synapse_Homo sapiens_hsa04726	0.39418526
88	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.38990813
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.36687788
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36364455
91	Folate biosynthesis_Homo sapiens_hsa00790	0.35919314
92	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35337667
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.34080502
94	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.32922560
95	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.31858898
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29530411
97	Non-homologous end-joining_Homo sapiens_hsa03450	0.25940131
98	Salivary secretion_Homo sapiens_hsa04970	0.24830943
99	Primary immunodeficiency_Homo sapiens_hsa05340	0.24241819
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.22600668

RPL22P19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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