RPL23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.75938823
2ribosomal small subunit biogenesis (GO:0042274)9.61894934
3* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.69625468
4* translational elongation (GO:0006414)8.65439896
5* cotranslational protein targeting to membrane (GO:0006613)8.53772456
6* protein targeting to ER (GO:0045047)8.53117764
7* establishment of protein localization to endoplasmic reticulum (GO:0072599)8.16483627
8* protein localization to endoplasmic reticulum (GO:0070972)7.96594109
9* cellular protein complex disassembly (GO:0043624)7.95379693
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.94758705
11* viral life cycle (GO:0019058)7.91847973
12maturation of SSU-rRNA (GO:0030490)7.75390617
13* translational initiation (GO:0006413)7.41981106
14ribosomal large subunit biogenesis (GO:0042273)7.06320016
15* protein complex disassembly (GO:0043241)6.89371658
16* macromolecular complex disassembly (GO:0032984)6.43806430
17* protein targeting to membrane (GO:0006612)5.70820181
18* nuclear-transcribed mRNA catabolic process (GO:0000956)5.59524684
19* mRNA catabolic process (GO:0006402)5.31185446
20* translation (GO:0006412)5.24840911
21ribonucleoprotein complex biogenesis (GO:0022613)5.19845306
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.91969705
23* RNA catabolic process (GO:0006401)4.91822217
24chaperone-mediated protein transport (GO:0072321)4.77813625
25rRNA processing (GO:0006364)4.05148815
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.03729339
27respiratory electron transport chain (GO:0022904)3.97613064
28DNA deamination (GO:0045006)3.92655996
29rRNA metabolic process (GO:0016072)3.89719564
30electron transport chain (GO:0022900)3.88442086
31regulation of mitochondrial translation (GO:0070129)3.88222195
32cellular component biogenesis (GO:0044085)3.85527819
33* establishment of protein localization to membrane (GO:0090150)3.81038075
34formation of translation preinitiation complex (GO:0001731)3.77423030
35ncRNA 3-end processing (GO:0043628)3.65656499
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49920576
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.49920576
38NADH dehydrogenase complex assembly (GO:0010257)3.49920576
39* protein targeting (GO:0006605)3.48703894
40* establishment of protein localization to organelle (GO:0072594)3.46545920
41protein complex biogenesis (GO:0070271)3.42331588
42mitochondrial respiratory chain complex assembly (GO:0033108)3.40913280
43DNA strand elongation involved in DNA replication (GO:0006271)3.28088804
44telomere maintenance via semi-conservative replication (GO:0032201)3.26950112
45protein targeting to mitochondrion (GO:0006626)3.19161672
46spliceosomal snRNP assembly (GO:0000387)3.13075790
47DNA strand elongation (GO:0022616)3.10402122
48inner mitochondrial membrane organization (GO:0007007)3.06316287
49spliceosomal complex assembly (GO:0000245)3.04443583
50negative regulation of RNA splicing (GO:0033119)3.01777638
51establishment of protein localization to mitochondrion (GO:0072655)3.01313508
52DNA replication initiation (GO:0006270)2.95250843
53histone exchange (GO:0043486)2.95223175
54protein localization to mitochondrion (GO:0070585)2.91179586
55ATP biosynthetic process (GO:0006754)2.90009078
56* protein localization to membrane (GO:0072657)2.88839413
57telomere maintenance via recombination (GO:0000722)2.88701039
58* cellular component disassembly (GO:0022411)2.85550997
59oxidative phosphorylation (GO:0006119)2.84146357
60protein neddylation (GO:0045116)2.83583390
61CENP-A containing nucleosome assembly (GO:0034080)2.81526287
62termination of RNA polymerase III transcription (GO:0006386)2.81414367
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.81414367
64ribosome biogenesis (GO:0042254)2.81097653
65chromatin remodeling at centromere (GO:0031055)2.80059100
66DNA unwinding involved in DNA replication (GO:0006268)2.79257321
67kinetochore organization (GO:0051383)2.77569644
68DNA replication checkpoint (GO:0000076)2.77384295
69maturation of 5.8S rRNA (GO:0000460)2.77380699
70purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.76416988
71cullin deneddylation (GO:0010388)2.75311125
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75140522
73purine nucleoside triphosphate biosynthetic process (GO:0009145)2.74852890
74mitotic recombination (GO:0006312)2.73851762
75purine nucleobase biosynthetic process (GO:0009113)2.72374624
76proteasome assembly (GO:0043248)2.71414335
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.71313267
78intracellular protein transmembrane import (GO:0044743)2.70856666
79pseudouridine synthesis (GO:0001522)2.70251169
80ncRNA processing (GO:0034470)2.70181671
81ribonucleoside triphosphate biosynthetic process (GO:0009201)2.67307404
82ATP synthesis coupled proton transport (GO:0015986)2.65496662
83energy coupled proton transport, down electrochemical gradient (GO:0015985)2.65496662
84histone mRNA metabolic process (GO:0008334)2.63107919
85* gene expression (GO:0010467)2.62699936
86nucleobase biosynthetic process (GO:0046112)2.62592294
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62126197
88telomere maintenance via telomere lengthening (GO:0010833)2.61762158
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.61748228
90ribosome assembly (GO:0042255)2.60750047
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59440799
92* protein localization to organelle (GO:0033365)2.58680547
93establishment of integrated proviral latency (GO:0075713)2.57670271
94protein localization to kinetochore (GO:0034501)2.57547724
95UTP biosynthetic process (GO:0006228)2.55330894
96GTP biosynthetic process (GO:0006183)2.54056086
97respiratory chain complex IV assembly (GO:0008535)2.53242680
98kinetochore assembly (GO:0051382)2.52115208
99cytochrome complex assembly (GO:0017004)2.50821057
100DNA replication-independent nucleosome organization (GO:0034724)2.50593958
101DNA replication-independent nucleosome assembly (GO:0006336)2.50593958
102aerobic respiration (GO:0009060)2.49460379
103ncRNA metabolic process (GO:0034660)2.47380369
104ribonucleoprotein complex assembly (GO:0022618)2.47319749
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47113073
106nucleotide-excision repair, DNA gap filling (GO:0006297)2.46310784
107termination of RNA polymerase II transcription (GO:0006369)2.45617200
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.44847266
109negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.40091284
110folic acid-containing compound biosynthetic process (GO:0009396)2.38123753
111transcription-coupled nucleotide-excision repair (GO:0006283)2.36855836
112DNA-templated transcription, termination (GO:0006353)2.36662588
113termination of RNA polymerase I transcription (GO:0006363)2.36536092
114RNA splicing, via transesterification reactions (GO:0000375)2.36497820
115mRNA splicing, via spliceosome (GO:0000398)2.35394115
116RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.35394115
117ribonucleoprotein complex subunit organization (GO:0071826)2.33528119
118DNA replication-dependent nucleosome assembly (GO:0006335)2.31732794
119DNA replication-dependent nucleosome organization (GO:0034723)2.31732794
120transcription elongation from RNA polymerase I promoter (GO:0006362)2.30648693
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.30543558
122pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.29499792
123transcription from RNA polymerase I promoter (GO:0006360)2.25623019
124rRNA modification (GO:0000154)2.25137135
125protein localization to chromosome, centromeric region (GO:0071459)2.24775572
126pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.24618923
127DNA damage response, detection of DNA damage (GO:0042769)2.24081323
128negative regulation of ligase activity (GO:0051352)2.22578268
129negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.22578268
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.22447326
131IMP biosynthetic process (GO:0006188)2.22216228
132* viral transcription (GO:0019083)10.6898392
133* translational termination (GO:0006415)10.2866790

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.34755044
2* MYC_18555785_ChIP-Seq_MESCs_Mouse5.07525240
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.58942870
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87308680
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.69194882
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.19247740
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.10923692
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04543335
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97858800
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.92315637
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89175365
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.87490657
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82493771
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79303740
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77657906
16* XRN2_22483619_ChIP-Seq_HELA_Human2.77313003
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58373048
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54339815
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.52252251
20* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40572538
21* TTF2_22483619_ChIP-Seq_HELA_Human2.37267196
22* VDR_23849224_ChIP-Seq_CD4+_Human2.31359014
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.26541708
24DCP1A_22483619_ChIP-Seq_HELA_Human2.24818528
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13595553
26* ELK1_19687146_ChIP-ChIP_HELA_Human2.11434063
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09193633
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.06740767
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04812119
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03353082
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99671240
32FOXP3_21729870_ChIP-Seq_TREG_Human1.96224685
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86239381
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75094946
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63080217
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57057993
37GABP_19822575_ChIP-Seq_HepG2_Human1.56535032
38* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54706749
39ELK1_22589737_ChIP-Seq_MCF10A_Human1.54114008
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52168752
41KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.51374720
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.50925537
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50037960
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48886852
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48263774
46AR_21909140_ChIP-Seq_LNCAP_Human1.47080984
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46602838
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.46543627
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45554901
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45134964
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45026178
52EWS_26573619_Chip-Seq_HEK293_Human1.43416100
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43057124
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.42383152
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.39906140
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37420910
57FUS_26573619_Chip-Seq_HEK293_Human1.35890088
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34883706
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34745912
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33331401
61MYC_18940864_ChIP-ChIP_HL60_Human1.32132612
62MYC_22102868_ChIP-Seq_BL_Human1.32068148
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30846235
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30201293
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29554131
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26930339
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26880946
68VDR_21846776_ChIP-Seq_THP-1_Human1.25820751
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.21432709
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.21230487
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20150864
72SPI1_23547873_ChIP-Seq_NB4_Human1.20119308
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20027232
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18538132
75* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17073233
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.16499307
77CIITA_25753668_ChIP-Seq_RAJI_Human1.15981192
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13971324
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.10483838
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09270240
81KDM5A_27292631_Chip-Seq_BREAST_Human1.07633676
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06416685
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06414350
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06305268
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06071370
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06040406
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06040406
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06040406
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03935482
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03700299
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03533229
92TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02331363
93* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02173829
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01194109
95* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00119293
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99018319
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98544692
98* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96408708
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95926979
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95631181
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.94422714
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93477179
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92408804
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91945930
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89692663
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88976108
107SALL1_21062744_ChIP-ChIP_HESCs_Human0.88924203
108TFEB_21752829_ChIP-Seq_HELA_Human0.88557436
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87971308
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86304769
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86046546
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84956858
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84399553
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83285854
115* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83035463
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79570783
117ELF5_23300383_ChIP-Seq_T47D_Human0.78056745
118BMI1_23680149_ChIP-Seq_NPCS_Mouse0.76358094
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71117424
120FOXP1_21924763_ChIP-Seq_HESCs_Human0.69503317
121CTCF_18555785_ChIP-Seq_MESCs_Mouse0.65399697
122CHD1_26751641_Chip-Seq_LNCaP_Human0.64966550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.31988864
2MP0003693_abnormal_embryo_hatching3.80041067
3MP0004957_abnormal_blastocyst_morpholog3.36316525
4MP0006292_abnormal_olfactory_placode3.02455647
5MP0010094_abnormal_chromosome_stability2.65308894
6MP0003077_abnormal_cell_cycle2.51312402
7MP0003941_abnormal_skin_development2.40079763
8MP0003111_abnormal_nucleus_morphology2.32007471
9MP0000566_synostosis2.14811630
10MP0008932_abnormal_embryonic_tissue2.09464688
11MP0002396_abnormal_hematopoietic_system2.06797975
12MP0008057_abnormal_DNA_replication2.04284156
13MP0008007_abnormal_cellular_replicative1.96648935
14MP0003937_abnormal_limbs/digits/tail_de1.90364450
15MP0000490_abnormal_crypts_of1.83431827
16MP0008058_abnormal_DNA_repair1.80803771
17MP0008995_early_reproductive_senescence1.69191916
18MP0003786_premature_aging1.66550253
19MP0001346_abnormal_lacrimal_gland1.62243187
20MP0004808_abnormal_hematopoietic_stem1.59271685
21MP0003136_yellow_coat_color1.57651240
22MP0002697_abnormal_eye_size1.55754031
23MP0001286_abnormal_eye_development1.55684737
24MP0004381_abnormal_hair_follicle1.53673030
25MP0005174_abnormal_tail_pigmentation1.52991297
26MP0010030_abnormal_orbit_morphology1.52876955
27MP0010352_gastrointestinal_tract_polyps1.50431348
28MP0009333_abnormal_splenocyte_physiolog1.49401455
29MP0003567_abnormal_fetal_cardiomyocyte1.45297533
30MP0002132_abnormal_respiratory_system1.43628138
31MP0002160_abnormal_reproductive_system1.42163157
32MP0006054_spinal_hemorrhage1.40505186
33MP0000350_abnormal_cell_proliferation1.38701682
34MP0003763_abnormal_thymus_physiology1.34948807
35MP0000631_abnormal_neuroendocrine_gland1.32595305
36MP0005187_abnormal_penis_morphology1.32261037
37MP0002796_impaired_skin_barrier1.30940816
38MP0009697_abnormal_copulation1.29719292
39MP0003123_paternal_imprinting1.27314846
40MP0002095_abnormal_skin_pigmentation1.24972342
41MP0003283_abnormal_digestive_organ1.24034979
42MP0005408_hypopigmentation1.22908760
43MP0005501_abnormal_skin_physiology1.22802204
44MP0009250_abnormal_appendicular_skeleto1.21594754
45MP0003890_abnormal_embryonic-extraembry1.19514910
46MP0006072_abnormal_retinal_apoptosis1.19415665
47MP0002277_abnormal_respiratory_mucosa1.18075431
48MP0002938_white_spotting1.17468763
49MP0000858_altered_metastatic_potential1.16469315
50MP0002233_abnormal_nose_morphology1.15922195
51MP0003119_abnormal_digestive_system1.15171738
52MP0003315_abnormal_perineum_morphology1.14382088
53MP0001529_abnormal_vocalization1.13809729
54MP0008789_abnormal_olfactory_epithelium1.13690125
55MP0001730_embryonic_growth_arrest1.10375869
56MP0002019_abnormal_tumor_incidence1.08988858
57MP0003724_increased_susceptibility_to1.08952277
58MP0000703_abnormal_thymus_morphology1.08597628
59MP0002751_abnormal_autonomic_nervous1.08483673
60MP0010307_abnormal_tumor_latency1.08445451
61MP0001545_abnormal_hematopoietic_system1.08366892
62MP0005397_hematopoietic_system_phenotyp1.08366892
63MP0001485_abnormal_pinna_reflex1.08005309
64MP0002398_abnormal_bone_marrow1.07324433
65MP0002282_abnormal_trachea_morphology1.06965395
66MP0003942_abnormal_urinary_system1.06925583
67MP0002722_abnormal_immune_system1.05041567
68MP0000465_gastrointestinal_hemorrhage1.04646547
69MP0001835_abnormal_antigen_presentation1.04569152
70MP0003755_abnormal_palate_morphology1.04441499
71MP0003436_decreased_susceptibility_to1.04333755
72MP0000049_abnormal_middle_ear1.03847401
73MP0009053_abnormal_anal_canal1.03083720
74MP0000313_abnormal_cell_death1.01084502
75MP0001800_abnormal_humoral_immune1.00864813
76MP0002166_altered_tumor_susceptibility1.00682820
77MP0002111_abnormal_tail_morphology1.00336043
78MP0002210_abnormal_sex_determination0.99922252
79MP0002060_abnormal_skin_morphology0.99874732
80MP0000685_abnormal_immune_system0.99139465
81MP0002102_abnormal_ear_morphology0.98215964
82MP0002148_abnormal_hypersensitivity_rea0.98078753
83MP0005379_endocrine/exocrine_gland_phen0.97866766
84MP0006036_abnormal_mitochondrial_physio0.97570815
85MP0001853_heart_inflammation0.97366767
86MP0001697_abnormal_embryo_size0.96958392
87MP0001881_abnormal_mammary_gland0.95177993
88MP0002234_abnormal_pharynx_morphology0.94771929
89MP0003011_delayed_dark_adaptation0.94688707
90MP0005023_abnormal_wound_healing0.93850566
91MP0000647_abnormal_sebaceous_gland0.93657041
92MP0000689_abnormal_spleen_morphology0.93533389
93MP0000372_irregular_coat_pigmentation0.91995609
94MP0002080_prenatal_lethality0.91906302
95MP0002452_abnormal_antigen_presenting0.91331865
96MP0002420_abnormal_adaptive_immunity0.91108112
97MP0005075_abnormal_melanosome_morpholog0.90621020
98MP0001216_abnormal_epidermal_layer0.89791915
99MP0003828_pulmonary_edema0.89681654
100MP0006035_abnormal_mitochondrial_morpho0.89458131
101MP0001819_abnormal_immune_cell0.89116800
102MP0001188_hyperpigmentation0.89090714
103MP0009785_altered_susceptibility_to0.89035145
104MP0002249_abnormal_larynx_morphology0.88772192
105MP0002429_abnormal_blood_cell0.88515297
106MP0002006_tumorigenesis0.87722525
107MP0010155_abnormal_intestine_physiology0.87669117
108MP0002405_respiratory_system_inflammati0.87108254
109MP0001293_anophthalmia0.87015475
110MP0002085_abnormal_embryonic_tissue0.86692631
111MP0000428_abnormal_craniofacial_morphol0.86414125
112MP0005646_abnormal_pituitary_gland0.86397722
113MP0005389_reproductive_system_phenotype0.86372209
114MP0001145_abnormal_male_reproductive0.86250222
115MP0005084_abnormal_gallbladder_morpholo0.86088792
116MP0005671_abnormal_response_to0.84976590
117MP0005000_abnormal_immune_tolerance0.83743612
118MP0003303_peritoneal_inflammation0.83741782
119MP0005380_embryogenesis_phenotype0.83484026
120MP0001672_abnormal_embryogenesis/_devel0.83484026
121MP0005025_abnormal_response_to0.83475430
122MP0000762_abnormal_tongue_morphology0.83115458
123MP0002098_abnormal_vibrissa_morphology0.82495555
124MP0000716_abnormal_immune_system0.82418007
125MP0004197_abnormal_fetal_growth/weight/0.81483902
126MP0000653_abnormal_sex_gland0.81467170
127MP0003936_abnormal_reproductive_system0.81226339
128MP0002723_abnormal_immune_serum0.80412975
129MP0002086_abnormal_extraembryonic_tissu0.79643707
130MP0000537_abnormal_urethra_morphology0.79386580
131MP0003453_abnormal_keratinocyte_physiol0.78094817
132MP0009672_abnormal_birth_weight0.77815301
133MP0003938_abnormal_ear_development0.77185066
134MP0002092_abnormal_eye_morphology0.76657848
135MP0002084_abnormal_developmental_patter0.76593506
136MP0003186_abnormal_redox_activity0.75909203
137MP0000377_abnormal_hair_follicle0.75523164
138MP0000750_abnormal_muscle_regeneration0.75007009
139MP0000613_abnormal_salivary_gland0.74959922
140MP0002163_abnormal_gland_morphology0.74902860
141MP0002177_abnormal_outer_ear0.74535039
142MP0002088_abnormal_embryonic_growth/wei0.74269835
143MP0005076_abnormal_cell_differentiation0.73437856
144MP0003984_embryonic_growth_retardation0.72536045
145MP0003718_maternal_effect0.72389077
146MP0004133_heterotaxia0.71967992
147MP0001119_abnormal_female_reproductive0.70905901
148MP0005377_hearing/vestibular/ear_phenot0.70550665
149MP0003878_abnormal_ear_physiology0.70550665
150MP0001324_abnormal_eye_pigmentation0.69882601
151MP0000516_abnormal_urinary_system0.69658394
152MP0005367_renal/urinary_system_phenotyp0.69658394
153MP0005391_vision/eye_phenotype0.69636866
154MP0000627_abnormal_mammary_gland0.68865939
155MP0003935_abnormal_craniofacial_develop0.66209807

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.35360660
2Reticulocytopenia (HP:0001896)8.96456209
3Abnormal number of erythroid precursors (HP:0012131)8.37563433
4Macrocytic anemia (HP:0001972)6.64981279
5Pallor (HP:0000980)6.22197953
6Abnormal hemoglobin (HP:0011902)4.33969509
7Thrombocytosis (HP:0001894)3.65218031
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.63665593
9Congenital, generalized hypertrichosis (HP:0004540)3.53148114
10Colon cancer (HP:0003003)3.42222686
11Aplastic anemia (HP:0001915)3.11939898
12Absent thumb (HP:0009777)2.98268986
13Depressed nasal ridge (HP:0000457)2.96019770
1411 pairs of ribs (HP:0000878)2.92055455
15Increased hepatocellular lipid droplets (HP:0006565)2.89748320
16Cerebral edema (HP:0002181)2.86278571
17Abnormality of reticulocytes (HP:0004312)2.86063103
18Trismus (HP:0000211)2.75950245
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59312026
20Stenosis of the external auditory canal (HP:0000402)2.57311452
21Multiple enchondromatosis (HP:0005701)2.57047228
22Triphalangeal thumb (HP:0001199)2.53184828
23Exertional dyspnea (HP:0002875)2.48743402
24Bilateral microphthalmos (HP:0007633)2.45430815
25Migraine (HP:0002076)2.44010517
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43671863
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43671863
28Woolly hair (HP:0002224)2.43365739
29Lipid accumulation in hepatocytes (HP:0006561)2.42648347
30Thick lower lip vermilion (HP:0000179)2.40426879
31Concave nail (HP:0001598)2.36824798
32Septo-optic dysplasia (HP:0100842)2.35973489
33Sparse lateral eyebrow (HP:0005338)2.35669351
34Oral leukoplakia (HP:0002745)2.34687806
35Mitochondrial inheritance (HP:0001427)2.31336809
36Partial duplication of the phalanx of hand (HP:0009999)2.27449266
37Breast hypoplasia (HP:0003187)2.24190259
38Esophageal atresia (HP:0002032)2.21676982
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21352194
40Hypoplasia of the radius (HP:0002984)2.20684817
41Acute necrotizing encephalopathy (HP:0006965)2.19933071
42Rough bone trabeculation (HP:0100670)2.18486889
43Respiratory difficulties (HP:0002880)2.14741019
44Birth length less than 3rd percentile (HP:0003561)2.14503270
45Lactic acidosis (HP:0003128)2.10309976
46Respiratory failure (HP:0002878)2.09893856
47Short middle phalanx of the 5th finger (HP:0004220)2.08456955
48Abnormal number of incisors (HP:0011064)2.07987817
49Leukodystrophy (HP:0002415)2.07888942
50Anophthalmia (HP:0000528)2.07300984
51Maternal diabetes (HP:0009800)2.06611834
52Asplenia (HP:0001746)2.05438940
53Myelodysplasia (HP:0002863)2.03962661
54Glossoptosis (HP:0000162)2.03469010
55Hepatocellular necrosis (HP:0001404)2.01278978
56Atresia of the external auditory canal (HP:0000413)2.00506632
57Sparse eyelashes (HP:0000653)2.00219935
58Chronic sinusitis (HP:0011109)1.99421312
59Selective tooth agenesis (HP:0001592)1.99126428
60Cleft eyelid (HP:0000625)1.97760015
61Abnormality of methionine metabolism (HP:0010901)1.97107205
62Missing ribs (HP:0000921)1.96913107
63Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95863999
64Increased CSF lactate (HP:0002490)1.95712182
65Optic disc pallor (HP:0000543)1.93527082
66Short hallux (HP:0010109)1.93456235
67Renal Fanconi syndrome (HP:0001994)1.91258478
68Abnormality of the parietal bone (HP:0002696)1.91122473
69Partial duplication of thumb phalanx (HP:0009944)1.90579097
70Abnormal mitochondria in muscle tissue (HP:0008316)1.88729211
71Aplasia/Hypoplasia of the uvula (HP:0010293)1.88558182
72Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.87521465
73Microretrognathia (HP:0000308)1.87519723
74Aplasia/Hypoplasia of the spleen (HP:0010451)1.86009564
75Abnormality of the axillary hair (HP:0100134)1.85684772
76Abnormality of secondary sexual hair (HP:0009888)1.85684772
77Increased intramyocellular lipid droplets (HP:0012240)1.83214110
78Megaloblastic anemia (HP:0001889)1.82878248
79Abnormality of the preputium (HP:0100587)1.82192135
80Sensory axonal neuropathy (HP:0003390)1.80669700
81Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.79955275
82IgM deficiency (HP:0002850)1.78933305
83Abnormality of the lacrimal duct (HP:0011481)1.78652094
84Abnormality of alanine metabolism (HP:0010916)1.78525128
85Hyperalaninemia (HP:0003348)1.78525128
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78525128
87Horseshoe kidney (HP:0000085)1.78394244
88Short thumb (HP:0009778)1.77962322
89Progressive macrocephaly (HP:0004481)1.77721834
90Abnormality of glycolysis (HP:0004366)1.75516873
91Hyperglycinemia (HP:0002154)1.75183035
92Premature graying of hair (HP:0002216)1.74392127
93Aplasia/Hypoplasia of the hallux (HP:0008362)1.73887937
94Fragile nails (HP:0001808)1.73527114
95Nasolacrimal duct obstruction (HP:0000579)1.73498876
96Meckel diverticulum (HP:0002245)1.73010663
97Carpal bone hypoplasia (HP:0001498)1.71885385
98Increased serum pyruvate (HP:0003542)1.71782133
99Abnormality of the labia minora (HP:0012880)1.71099494
100Hypothermia (HP:0002045)1.71094448
101Abnormality of the phalanges of the 5th finger (HP:0004213)1.71051567
102Lethargy (HP:0001254)1.70634450
103Methylmalonic acidemia (HP:0002912)1.70608121
104Entropion (HP:0000621)1.69768877
105Abnormality of renal resorption (HP:0011038)1.69335131
106Neoplasm of the pancreas (HP:0002894)1.69018135
107Absent septum pellucidum (HP:0001331)1.66095983
108Elevated erythrocyte sedimentation rate (HP:0003565)1.64930720
109Abnormality of the phalanges of the 2nd finger (HP:0009541)1.64841292
110Pancreatic cysts (HP:0001737)1.64405680
111Patellar aplasia (HP:0006443)1.63969303
112Abnormality of the nasolacrimal system (HP:0000614)1.63753716
113Abnormality of the ileum (HP:0001549)1.62933423
114Chromsome breakage (HP:0040012)1.60718261
115Hepatic necrosis (HP:0002605)1.60659521
116Absent radius (HP:0003974)1.60190105
117Pancytopenia (HP:0001876)1.59303515
1183-Methylglutaconic aciduria (HP:0003535)1.58781788
119Poikiloderma (HP:0001029)1.58384948
120Aplasia/Hypoplasia of the patella (HP:0006498)1.57373344
121Petechiae (HP:0000967)1.56093955
122Abnormal trabecular bone morphology (HP:0100671)1.56093234
123Increased serum lactate (HP:0002151)1.54840034
124Exercise intolerance (HP:0003546)1.52665173
125Type I transferrin isoform profile (HP:0003642)1.51124216
126Secondary amenorrhea (HP:0000869)1.50671821
127Microvesicular hepatic steatosis (HP:0001414)1.50370941
128Tracheoesophageal fistula (HP:0002575)1.49480101
129Supernumerary spleens (HP:0009799)1.49330407
130Aplasia/Hypoplasia of the thymus (HP:0010515)1.48860791
131Abnormality of chromosome stability (HP:0003220)1.48711412
132Acute encephalopathy (HP:0006846)1.47997883
133Down-sloping shoulders (HP:0200021)1.47349278
134Aplasia involving forearm bones (HP:0009822)1.46628179
135Absent forearm bone (HP:0003953)1.46628179
136Abnormal lung lobation (HP:0002101)1.44660093
137Short nose (HP:0003196)1.44584039
138Muscle fiber atrophy (HP:0100295)1.43098293
139Lymphoma (HP:0002665)1.42625004
140Duplication of thumb phalanx (HP:0009942)1.42597625
141Increased muscle lipid content (HP:0009058)1.42595426
142Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.41671878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.05038156
2VRK24.34625129
3TLK13.92776420
4WEE13.25774904
5BUB12.85036810
6EIF2AK12.59742560
7RPS6KB22.47585109
8STK242.47534404
9TAF12.39330737
10SRPK12.29323145
11LRRK22.14963689
12STK162.10595975
13MST42.08937315
14TGFBR12.01561124
15NEK11.97716674
16CDC71.97331244
17PIM21.97208473
18NUAK11.95332787
19DYRK31.93461243
20VRK11.87157787
21ZAK1.85878500
22MKNK11.75971389
23EEF2K1.75511415
24RPS6KA41.65592816
25ACVR1B1.51908254
26AURKB1.50582601
27TESK21.48207482
28BRSK21.47230439
29NEK21.46736814
30CDK71.45628735
31EIF2AK31.45120775
32TNIK1.43725840
33PDK21.33173476
34MAP3K131.31005042
35MKNK21.26670199
36PASK1.25908842
37PNCK1.22470888
38PLK11.21861700
39TEC1.19001396
40ILK1.15025750
41STK101.09908001
42MAPKAPK31.09621166
43MAP4K11.09376751
44CDK191.08749988
45FLT31.08661430
46BRSK11.07826853
47NME11.06787580
48CDK81.06726808
49PIM11.00692058
50PLK41.00121407
51PAK40.96844033
52TTK0.95368513
53FGFR20.94111100
54BLK0.92424763
55BTK0.89870961
56PBK0.89218553
57AURKA0.85823130
58MAP3K80.85051395
59KDR0.84802574
60GRK10.83938217
61EIF2AK20.82374817
62ATR0.82323568
63FGFR10.81518206
64RPS6KA50.80384781
65STK390.79675240
66CSNK2A20.79498650
67NLK0.78340716
68EPHA20.77861895
69CDK40.77574278
70CLK10.76643751
71MAP3K100.75646955
72WNK30.75533471
73KIT0.75287123
74IKBKB0.74178860
75TRIM280.73298959
76INSRR0.72785741
77STK30.72771674
78NEK90.71939373
79SCYL20.71307031
80CSNK2A10.70266652
81PAK20.70149596
82TSSK60.68877739
83PKN20.65736737
84MOS0.65221866
85CDK60.64669547
86CDK30.64335618
87MAP3K30.63509022
88MAPK150.63490875
89STK40.62626455
90MST1R0.59416312
91CHEK20.59160014
92EPHB20.58654311
93CSNK1E0.56575369
94BRAF0.55835028
95DYRK1B0.55145266
96SMG10.55053290
97MAPKAPK50.55007707
98PAK10.54096851
99BCKDK0.53648641
100STK38L0.53527539
101TGFBR20.53433666
102IRAK40.51961402
103DAPK30.51493047
104MAP2K30.51482501
105TYK20.50564012
106CHEK10.50090825
107ATM0.48252314
108CSF1R0.47009096
109IRAK30.46042033
110LYN0.45431380
111OXSR10.44363946
112LCK0.43816104
113ZAP700.42485863
114MAP3K110.42479877
115CDK90.41491286
116ABL20.41386582
117BMPR1B0.40179350
118LATS10.39632850
119PLK30.39248126
120TESK10.38943752
121DYRK20.38684104
122FES0.38311335
123GRK60.38015699
124MAP2K20.37006403
125MATK0.36882864
126CDK20.36816214
127CCNB10.36453720
128CSNK1G10.36333951
129MELK0.35994882
130TBK10.35494638
131MAPKAPK20.35319045
132PRKCI0.33494083
133ALK0.32566194
134ADRBK20.31841918
135WNK40.29841503
136CDK10.29626647
137PRKCG0.25998192
138PRKDC0.22347773
139MAP4K20.18865510
140ERBB40.17948156
141ARAF0.16517296
142CSNK1G30.16404616
143PIK3CA0.15867671

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030108.25092396
2DNA replication_Homo sapiens_hsa030303.62737863
3RNA polymerase_Homo sapiens_hsa030203.09072142
4Spliceosome_Homo sapiens_hsa030402.93954203
5Mismatch repair_Homo sapiens_hsa034302.93096564
6Proteasome_Homo sapiens_hsa030502.77566668
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66270419
8Homologous recombination_Homo sapiens_hsa034402.45840571
9Nucleotide excision repair_Homo sapiens_hsa034202.28934718
10Pyrimidine metabolism_Homo sapiens_hsa002402.21294346
11RNA transport_Homo sapiens_hsa030132.14537133
12Base excision repair_Homo sapiens_hsa034102.04400351
13One carbon pool by folate_Homo sapiens_hsa006701.89639613
14Protein export_Homo sapiens_hsa030601.89344345
15Parkinsons disease_Homo sapiens_hsa050121.69902949
16Oxidative phosphorylation_Homo sapiens_hsa001901.69303134
17Cell cycle_Homo sapiens_hsa041101.60084019
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57431832
19Fanconi anemia pathway_Homo sapiens_hsa034601.56337577
20Basal transcription factors_Homo sapiens_hsa030221.49704267
21Non-homologous end-joining_Homo sapiens_hsa034501.48749396
22RNA degradation_Homo sapiens_hsa030181.45508316
23Huntingtons disease_Homo sapiens_hsa050161.39336032
24p53 signaling pathway_Homo sapiens_hsa041151.34773590
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25498628
26Systemic lupus erythematosus_Homo sapiens_hsa053221.23249230
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12265857
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.11403001
29Sulfur relay system_Homo sapiens_hsa041221.10850930
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.10539850
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10104089
32mRNA surveillance pathway_Homo sapiens_hsa030151.05207742
33Antigen processing and presentation_Homo sapiens_hsa046121.04009846
34Herpes simplex infection_Homo sapiens_hsa051681.03594562
35Alzheimers disease_Homo sapiens_hsa050101.02087811
36Epstein-Barr virus infection_Homo sapiens_hsa051690.99372250
37Purine metabolism_Homo sapiens_hsa002300.98824670
38Pyruvate metabolism_Homo sapiens_hsa006200.96669011
39Primary immunodeficiency_Homo sapiens_hsa053400.96220649
40Selenocompound metabolism_Homo sapiens_hsa004500.80158028
41Propanoate metabolism_Homo sapiens_hsa006400.79257857
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78401427
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.76624975
44Hematopoietic cell lineage_Homo sapiens_hsa046400.76357889
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72919281
46Vitamin digestion and absorption_Homo sapiens_hsa049770.71946067
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71796599
48Thyroid cancer_Homo sapiens_hsa052160.71389901
49Folate biosynthesis_Homo sapiens_hsa007900.71142276
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70389517
51Vitamin B6 metabolism_Homo sapiens_hsa007500.70329692
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68605865
53HTLV-I infection_Homo sapiens_hsa051660.66978621
54Viral carcinogenesis_Homo sapiens_hsa052030.66294830
55Small cell lung cancer_Homo sapiens_hsa052220.66079148
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65560218
57Fatty acid elongation_Homo sapiens_hsa000620.62620472
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62328708
59Steroid biosynthesis_Homo sapiens_hsa001000.60478023
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56896765
61Legionellosis_Homo sapiens_hsa051340.56676880
62Measles_Homo sapiens_hsa051620.55122506
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54691081
64Basal cell carcinoma_Homo sapiens_hsa052170.53732768
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.53306270
66Arachidonic acid metabolism_Homo sapiens_hsa005900.52336543
67Nitrogen metabolism_Homo sapiens_hsa009100.52026037
68Glutathione metabolism_Homo sapiens_hsa004800.51489667
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50863968
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.50488373
71Apoptosis_Homo sapiens_hsa042100.49603295
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48763960
73Biosynthesis of amino acids_Homo sapiens_hsa012300.48587669
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48035016
75Carbon metabolism_Homo sapiens_hsa012000.47183247
76Tyrosine metabolism_Homo sapiens_hsa003500.46844572
77TGF-beta signaling pathway_Homo sapiens_hsa043500.46751837
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46496325
79MicroRNAs in cancer_Homo sapiens_hsa052060.45947760
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45677352
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.45299205
82Asthma_Homo sapiens_hsa053100.44362278
83Allograft rejection_Homo sapiens_hsa053300.42556523
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41619426
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40576894
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39567581
87Acute myeloid leukemia_Homo sapiens_hsa052210.39271925
88Hepatitis B_Homo sapiens_hsa051610.39137607
89Pentose phosphate pathway_Homo sapiens_hsa000300.39093916
90Bladder cancer_Homo sapiens_hsa052190.38756928
91Graft-versus-host disease_Homo sapiens_hsa053320.38588430
92Leishmaniasis_Homo sapiens_hsa051400.38524280
93Alcoholism_Homo sapiens_hsa050340.38117151
94Malaria_Homo sapiens_hsa051440.36584488
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36572455
96Pathways in cancer_Homo sapiens_hsa052000.34468497
97Caffeine metabolism_Homo sapiens_hsa002320.33538898
98Peroxisome_Homo sapiens_hsa041460.33196114
99N-Glycan biosynthesis_Homo sapiens_hsa005100.33103609
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32969362
101Viral myocarditis_Homo sapiens_hsa054160.32309778
102Fat digestion and absorption_Homo sapiens_hsa049750.31906258
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.31868230
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31003294
105Arginine and proline metabolism_Homo sapiens_hsa003300.30187260
106Fatty acid degradation_Homo sapiens_hsa000710.28872666
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28820508
108Shigellosis_Homo sapiens_hsa051310.28294197
109Linoleic acid metabolism_Homo sapiens_hsa005910.27920411
110Notch signaling pathway_Homo sapiens_hsa043300.27364805
111Hippo signaling pathway_Homo sapiens_hsa043900.27305791
112Retinol metabolism_Homo sapiens_hsa008300.26783339
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.26640105
114B cell receptor signaling pathway_Homo sapiens_hsa046620.26453166
115Influenza A_Homo sapiens_hsa051640.26419394
116Cardiac muscle contraction_Homo sapiens_hsa042600.26400024
117Chronic myeloid leukemia_Homo sapiens_hsa052200.26364456
118HIF-1 signaling pathway_Homo sapiens_hsa040660.25843830
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25665002
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24767500
121Sulfur metabolism_Homo sapiens_hsa009200.24671954
122Autoimmune thyroid disease_Homo sapiens_hsa053200.24508315
123ECM-receptor interaction_Homo sapiens_hsa045120.24183733
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23895351
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23015091
126Toxoplasmosis_Homo sapiens_hsa051450.22835253
127Chemical carcinogenesis_Homo sapiens_hsa052040.21792389
128Proteoglycans in cancer_Homo sapiens_hsa052050.21477518
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21288324
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21007367
131Pertussis_Homo sapiens_hsa051330.20197472
132Metabolic pathways_Homo sapiens_hsa011000.19779128
133Tryptophan metabolism_Homo sapiens_hsa003800.19449338
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.19240279
135Hedgehog signaling pathway_Homo sapiens_hsa043400.18787490
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18047265
137Wnt signaling pathway_Homo sapiens_hsa043100.17849260
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16890974
139Oocyte meiosis_Homo sapiens_hsa041140.16511945
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16190644
141Phototransduction_Homo sapiens_hsa047440.14564596
142Fatty acid metabolism_Homo sapiens_hsa012120.12388895
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11972133
144Butanoate metabolism_Homo sapiens_hsa006500.11418479
145Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10159522
146Galactose metabolism_Homo sapiens_hsa000520.09773609
147Melanoma_Homo sapiens_hsa052180.05818905

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