RPL23A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.44445625
2* viral transcription (GO:0019083)8.11964279
3* translational termination (GO:0006415)7.84000523
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.61552271
5ribosomal small subunit biogenesis (GO:0042274)7.27782815
6ATP synthesis coupled proton transport (GO:0015986)7.04288536
7energy coupled proton transport, down electrochemical gradient (GO:0015985)7.04288536
8* translational elongation (GO:0006414)6.78702514
9* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.59054334
10* protein targeting to ER (GO:0045047)6.44078205
11* cotranslational protein targeting to membrane (GO:0006613)6.43726255
12maturation of SSU-rRNA (GO:0030490)6.39583950
13* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.30722624
14* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.15441362
15* cellular protein complex disassembly (GO:0043624)6.07754664
16* viral life cycle (GO:0019058)6.06509149
17* translational initiation (GO:0006413)6.03040253
18* protein localization to endoplasmic reticulum (GO:0070972)5.99759831
19ribosomal large subunit biogenesis (GO:0042273)5.46192385
20* protein complex disassembly (GO:0043241)5.40652630
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.37604469
22establishment of protein localization to mitochondrial membrane (GO:0090151)5.35425900
23respiratory electron transport chain (GO:0022904)5.26497798
24electron transport chain (GO:0022900)5.17895462
25* macromolecular complex disassembly (GO:0032984)5.04319963
26chaperone-mediated protein transport (GO:0072321)4.88102048
27protein complex biogenesis (GO:0070271)4.82076780
28* nuclear-transcribed mRNA catabolic process (GO:0000956)4.62955161
29mitochondrial respiratory chain complex assembly (GO:0033108)4.56425675
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.55660701
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.55660701
32NADH dehydrogenase complex assembly (GO:0010257)4.55660701
33formation of translation preinitiation complex (GO:0001731)4.55022569
34ribonucleoprotein complex biogenesis (GO:0022613)4.45666794
35* mRNA catabolic process (GO:0006402)4.39590004
36* protein targeting to membrane (GO:0006612)4.26868106
37* translation (GO:0006412)4.22870732
38* RNA catabolic process (GO:0006401)4.17110984
39proteasome assembly (GO:0043248)4.08795530
40ATP biosynthetic process (GO:0006754)3.97696427
41DNA strand elongation involved in DNA replication (GO:0006271)3.83951898
42DNA unwinding involved in DNA replication (GO:0006268)3.81442052
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.76355376
44termination of RNA polymerase III transcription (GO:0006386)3.76355376
45regulation of mitochondrial translation (GO:0070129)3.75102115
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.73982778
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.72397453
48oxidative phosphorylation (GO:0006119)3.68335083
49telomere maintenance via semi-conservative replication (GO:0032201)3.66370840
50DNA strand elongation (GO:0022616)3.63518792
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.59620202
52rRNA processing (GO:0006364)3.58363258
53rRNA modification (GO:0000154)3.52257558
54inner mitochondrial membrane organization (GO:0007007)3.49892401
55rRNA metabolic process (GO:0016072)3.45683990
56protein localization to kinetochore (GO:0034501)3.45283110
57DNA replication initiation (GO:0006270)3.44014238
58protein targeting to mitochondrion (GO:0006626)3.39240038
59ribonucleoside triphosphate biosynthetic process (GO:0009201)3.38311204
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31075732
61hydrogen ion transmembrane transport (GO:1902600)3.30453122
62DNA deamination (GO:0045006)3.28812221
63telomere maintenance via recombination (GO:0000722)3.26849415
64establishment of protein localization to mitochondrion (GO:0072655)3.21270761
65negative regulation of RNA splicing (GO:0033119)3.20741163
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20258754
67negative regulation of ligase activity (GO:0051352)3.20258754
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16751617
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.15761327
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.15761327
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15437549
72mitotic recombination (GO:0006312)3.14793185
73pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.14248550
74cellular component biogenesis (GO:0044085)3.11988270
75purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.09700799
76purine nucleoside monophosphate biosynthetic process (GO:0009127)3.09700799
77protein neddylation (GO:0045116)3.09272557
78protein localization to mitochondrion (GO:0070585)3.08979441
79mitotic nuclear envelope disassembly (GO:0007077)3.06635849
80ncRNA 3-end processing (GO:0043628)3.05594842
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04870962
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04244256
83ribosome biogenesis (GO:0042254)3.03747953
84protein localization to chromosome, centromeric region (GO:0071459)3.01740100
85nucleoside triphosphate biosynthetic process (GO:0009142)3.01723724
86ribosome assembly (GO:0042255)3.00555153
87telomere maintenance via telomere lengthening (GO:0010833)3.00446511
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00339197
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00339197
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00339197
91folic acid-containing compound biosynthetic process (GO:0009396)3.00282186
92signal transduction involved in DNA damage checkpoint (GO:0072422)2.99947295
93signal transduction involved in DNA integrity checkpoint (GO:0072401)2.99947295
94intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97944833
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97944833
96DNA replication checkpoint (GO:0000076)2.94743794
97signal transduction involved in cell cycle checkpoint (GO:0072395)2.93082586
98mitochondrial transport (GO:0006839)2.92943928
99GTP biosynthetic process (GO:0006183)2.92284036
100nucleobase biosynthetic process (GO:0046112)2.91649854
101IMP biosynthetic process (GO:0006188)2.91404043
102kinetochore organization (GO:0051383)2.91397749
103rRNA methylation (GO:0031167)2.90348826
104proton transport (GO:0015992)2.89779321
105cytochrome complex assembly (GO:0017004)2.89381604
106spliceosomal snRNP assembly (GO:0000387)2.88973115
107peptidyl-histidine modification (GO:0018202)2.87873511
108regulation of cellular amino acid metabolic process (GO:0006521)2.87615525
109CENP-A containing nucleosome assembly (GO:0034080)2.87314764
110intracellular protein transmembrane import (GO:0044743)2.86323750
111nucleotide-excision repair, DNA gap filling (GO:0006297)2.86242959
112chromatin remodeling at centromere (GO:0031055)2.86116819
113mitotic metaphase plate congression (GO:0007080)2.85436814
114* establishment of protein localization to membrane (GO:0090150)2.84451161
115hydrogen transport (GO:0006818)2.83766730
116DNA replication-dependent nucleosome organization (GO:0034723)2.82213223
117DNA replication-dependent nucleosome assembly (GO:0006335)2.82213223
118membrane disassembly (GO:0030397)2.81368418
119nuclear envelope disassembly (GO:0051081)2.81368418
120sequestering of actin monomers (GO:0042989)2.79762736
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.74455818
122nuclear pore organization (GO:0006999)2.74375499
123establishment of integrated proviral latency (GO:0075713)2.73840256
124DNA replication-independent nucleosome organization (GO:0034724)2.73217352
125DNA replication-independent nucleosome assembly (GO:0006336)2.73217352
126mRNA splicing, via spliceosome (GO:0000398)2.72076915
127RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.72076915
128RNA splicing, via transesterification reactions (GO:0000375)2.72004602
129spliceosomal complex assembly (GO:0000245)2.69179897
130* establishment of protein localization to organelle (GO:0072594)2.67807054
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.62101457
132termination of RNA polymerase II transcription (GO:0006369)2.61611527
133nuclear pore complex assembly (GO:0051292)2.61126807
134mitotic chromosome condensation (GO:0007076)2.61111410
135pseudouridine synthesis (GO:0001522)2.61027301
136IMP metabolic process (GO:0046040)2.59585768
137purine nucleobase biosynthetic process (GO:0009113)2.58526585
138metaphase plate congression (GO:0051310)2.57106086
139* protein targeting (GO:0006605)2.56523126
140DNA duplex unwinding (GO:0032508)2.54999423
141ribonucleoprotein complex assembly (GO:0022618)2.53367953
142DNA geometric change (GO:0032392)2.53259558
143* gene expression (GO:0010467)2.53077621
144transcription-coupled nucleotide-excision repair (GO:0006283)2.52022672
145kinetochore assembly (GO:0051382)2.50055589
146regulation of histone H3-K9 methylation (GO:0051570)2.49829293
147ncRNA processing (GO:0034470)2.47161417
148mitotic sister chromatid segregation (GO:0000070)2.45978475
149attachment of spindle microtubules to kinetochore (GO:0008608)2.45582296
150* cellular component disassembly (GO:0022411)2.43742357
151negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.43554621
152regulation of spindle organization (GO:0090224)2.42353539
153histone mRNA metabolic process (GO:0008334)2.41532487
154DNA topological change (GO:0006265)2.39691949
155regulation of protein heterodimerization activity (GO:0043497)2.38815647
156ribonucleoprotein complex subunit organization (GO:0071826)2.38654697
157negative regulation of mRNA processing (GO:0050686)2.38544514
158telomere maintenance (GO:0000723)2.37572426
159telomere organization (GO:0032200)2.37013505
160sister chromatid segregation (GO:0000819)2.36904310
161exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.36463025

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.37110510
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.50729642
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87230089
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.47312479
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.31834150
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18797985
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82919114
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.81670341
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78867009
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71301874
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68052885
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.66018294
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.58018391
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53898964
15* XRN2_22483619_ChIP-Seq_HELA_Human2.53622707
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43961751
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42626908
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.27768028
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26220953
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25357165
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21616068
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19244439
23* VDR_23849224_ChIP-Seq_CD4+_Human2.12538112
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04687980
25MYC_22102868_ChIP-Seq_BL_Human2.03768727
26TTF2_22483619_ChIP-Seq_HELA_Human1.99873949
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94614966
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94180820
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91901152
30DCP1A_22483619_ChIP-Seq_HELA_Human1.88096497
31FOXP3_21729870_ChIP-Seq_TREG_Human1.86506786
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85653899
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.82658937
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80208362
35* ELK1_19687146_ChIP-ChIP_HELA_Human1.76349494
36* E2F1_21310950_ChIP-Seq_MCF-7_Human1.68708605
37AR_21909140_ChIP-Seq_LNCAP_Human1.65813482
38GABP_19822575_ChIP-Seq_HepG2_Human1.58024065
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55527915
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53428215
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52152011
42CIITA_25753668_ChIP-Seq_RAJI_Human1.51496514
43VDR_21846776_ChIP-Seq_THP-1_Human1.50003151
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48435362
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47241036
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45904722
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43269800
48* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42894485
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38820656
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36463660
51* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36388348
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34866878
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33356619
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32972179
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32749499
56* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32657249
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32604657
58KDM5A_27292631_Chip-Seq_BREAST_Human1.31678262
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30527161
60* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28720332
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27111150
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26729691
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25939284
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25318745
65* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25147655
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20588741
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.20061120
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19984078
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19304754
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18325640
71* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17439172
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.16010906
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14724082
74SPI1_23547873_ChIP-Seq_NB4_Human1.14406903
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13443468
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13032987
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.10076714
78EWS_26573619_Chip-Seq_HEK293_Human1.09699888
79TFEB_21752829_ChIP-Seq_HELA_Human1.09633464
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08107472
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07911553
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07011563
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06439950
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05275637
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.03902176
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03208877
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.01579255
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01083242
89SRF_21415370_ChIP-Seq_HL-1_Mouse0.99748366
90TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98127246
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.97583153
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97455105
93VDR_22108803_ChIP-Seq_LS180_Human0.97139925
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96858406
95CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96848778
96* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96352652
97FUS_26573619_Chip-Seq_HEK293_Human0.95149502
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94613025
99UTX_26944678_Chip-Seq_JUKART_Human0.94238483
100* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94048293
101MAF_26560356_Chip-Seq_TH1_Human0.94025140
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93432470
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92958060
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92352646
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91854705
106PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90262989
107* MYC_18940864_ChIP-ChIP_HL60_Human0.90159005
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89549346
109* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88643384
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88355139
111NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86659291
112IRF1_19129219_ChIP-ChIP_H3396_Human0.85148541
113MAF_26560356_Chip-Seq_TH2_Human0.84554189
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82659617
115ZNF274_21170338_ChIP-Seq_K562_Hela0.81791853
116* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78857443
117BMI1_23680149_ChIP-Seq_NPCS_Mouse0.78153392
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77499485
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77499485
120ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75913127
121PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.74032404
122* FOXP1_21924763_ChIP-Seq_HESCs_Human0.73908302
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.72250948
124ERG_20517297_ChIP-Seq_VCAP_Human0.71060015
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71009011
126TP53_22573176_ChIP-Seq_HFKS_Human0.67981017
127YY1_22570637_ChIP-Seq_MALME-3M_Human0.66983093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.24154240
2MP0004957_abnormal_blastocyst_morpholog3.68840546
3MP0010094_abnormal_chromosome_stability3.32514204
4MP0003077_abnormal_cell_cycle3.14419961
5MP0003111_abnormal_nucleus_morphology3.08547719
6MP0009379_abnormal_foot_pigmentation2.97279616
7MP0006292_abnormal_olfactory_placode2.74162241
8MP0003806_abnormal_nucleotide_metabolis2.63427292
9MP0008057_abnormal_DNA_replication2.61985283
10MP0002396_abnormal_hematopoietic_system2.57681743
11MP0010352_gastrointestinal_tract_polyps2.49256373
12MP0008995_early_reproductive_senescence2.48921649
13MP0000372_irregular_coat_pigmentation2.44306763
14MP0003136_yellow_coat_color2.41736185
15MP0008007_abnormal_cellular_replicative2.31621121
16MP0008058_abnormal_DNA_repair2.17131016
17MP0002277_abnormal_respiratory_mucosa2.13758592
18MP0006072_abnormal_retinal_apoptosis2.10404826
19MP0008932_abnormal_embryonic_tissue1.98933128
20MP0002234_abnormal_pharynx_morphology1.97513877
21MP0002160_abnormal_reproductive_system1.93600961
22MP0002163_abnormal_gland_morphology1.89219263
23MP0006036_abnormal_mitochondrial_physio1.87038898
24MP0000490_abnormal_crypts_of1.83930169
25MP0000350_abnormal_cell_proliferation1.82055178
26MP0009697_abnormal_copulation1.80184540
27MP0003718_maternal_effect1.79390723
28MP0001730_embryonic_growth_arrest1.78713672
29MP0003763_abnormal_thymus_physiology1.78249736
30MP0004808_abnormal_hematopoietic_stem1.76791995
31MP0000049_abnormal_middle_ear1.72304613
32MP0003123_paternal_imprinting1.68356192
33MP0005075_abnormal_melanosome_morpholog1.58902337
34MP0009333_abnormal_splenocyte_physiolog1.56864659
35MP0006054_spinal_hemorrhage1.55585851
36MP0003567_abnormal_fetal_cardiomyocyte1.55276797
37MP0003786_premature_aging1.54328622
38MP0005084_abnormal_gallbladder_morpholo1.51838650
39MP0005389_reproductive_system_phenotype1.49554526
40MP0001545_abnormal_hematopoietic_system1.42604410
41MP0005397_hematopoietic_system_phenotyp1.42604410
42MP0010307_abnormal_tumor_latency1.40114919
43MP0002019_abnormal_tumor_incidence1.37765971
44MP0000703_abnormal_thymus_morphology1.36143656
45MP0001697_abnormal_embryo_size1.35825534
46MP0002398_abnormal_bone_marrow1.34772591
47MP0004197_abnormal_fetal_growth/weight/1.33534472
48MP0003011_delayed_dark_adaptation1.30822483
49MP0005076_abnormal_cell_differentiation1.30150259
50MP0005380_embryogenesis_phenotype1.28798007
51MP0001672_abnormal_embryogenesis/_devel1.28798007
52MP0002080_prenatal_lethality1.27716651
53MP0006035_abnormal_mitochondrial_morpho1.27409864
54MP0002722_abnormal_immune_system1.26001872
55MP0003705_abnormal_hypodermis_morpholog1.25871035
56MP0003941_abnormal_skin_development1.25233003
57MP0000858_altered_metastatic_potential1.24409138
58MP0000313_abnormal_cell_death1.23356854
59MP0005023_abnormal_wound_healing1.22105964
60MP0000685_abnormal_immune_system1.21657415
61MP0002166_altered_tumor_susceptibility1.20547702
62MP0000537_abnormal_urethra_morphology1.20491081
63MP0002086_abnormal_extraembryonic_tissu1.19648983
64MP0002822_catalepsy1.19392403
65MP0003984_embryonic_growth_retardation1.19051286
66MP0002085_abnormal_embryonic_tissue1.18402522
67MP0002088_abnormal_embryonic_growth/wei1.17663569
68MP0002084_abnormal_developmental_patter1.16518745
69MP0000631_abnormal_neuroendocrine_gland1.16322484
70MP0000678_abnormal_parathyroid_gland1.16033003
71MP0002837_dystrophic_cardiac_calcinosis1.14336985
72MP0010030_abnormal_orbit_morphology1.13500721
73MP0000689_abnormal_spleen_morphology1.13285224
74MP0001835_abnormal_antigen_presentation1.12153085
75MP0001905_abnormal_dopamine_level1.11727818
76MP0001919_abnormal_reproductive_system1.11277686
77MP0005501_abnormal_skin_physiology1.10155970
78MP0002210_abnormal_sex_determination1.09774710
79MP0001800_abnormal_humoral_immune1.08523696
80MP0004142_abnormal_muscle_tone1.07743700
81MP0001346_abnormal_lacrimal_gland1.05980093
82MP0009278_abnormal_bone_marrow1.05878614
83MP0003566_abnormal_cell_adhesion1.04726680
84MP0002429_abnormal_blood_cell1.04387547
85MP0002006_tumorigenesis1.04149119
86MP0009053_abnormal_anal_canal1.03795556
87MP0001529_abnormal_vocalization1.02688101
88MP0010234_abnormal_vibrissa_follicle1.02591968
89MP0002102_abnormal_ear_morphology1.02335966
90MP0001293_anophthalmia1.02310350
91MP0008872_abnormal_physiological_respon1.00817620
92MP0001853_heart_inflammation1.00641515
93MP0001145_abnormal_male_reproductive0.99367541
94MP0002638_abnormal_pupillary_reflex0.99064504
95MP0003315_abnormal_perineum_morphology0.98900658
96MP0000716_abnormal_immune_system0.98837918
97MP0002420_abnormal_adaptive_immunity0.96893234
98MP0005174_abnormal_tail_pigmentation0.96803716
99MP0001881_abnormal_mammary_gland0.96422653
100MP0001986_abnormal_taste_sensitivity0.95791234
101MP0005645_abnormal_hypothalamus_physiol0.95286314
102MP0001819_abnormal_immune_cell0.95043835
103MP0002405_respiratory_system_inflammati0.94732939
104MP0000653_abnormal_sex_gland0.94334190
105MP0002452_abnormal_antigen_presenting0.94299508
106MP0002736_abnormal_nociception_after0.94260847
107MP0003283_abnormal_digestive_organ0.93970741
108MP0001929_abnormal_gametogenesis0.92722204
109MP0002132_abnormal_respiratory_system0.92558248
110MP0001764_abnormal_homeostasis0.92408284
111MP0009250_abnormal_appendicular_skeleto0.92391131
112MP0005671_abnormal_response_to0.92240087
113MP0010155_abnormal_intestine_physiology0.92118338
114MP0003938_abnormal_ear_development0.91924358
115MP0005646_abnormal_pituitary_gland0.91840950
116MP0004147_increased_porphyrin_level0.90900624
117MP0002796_impaired_skin_barrier0.90786387
118MP0005379_endocrine/exocrine_gland_phen0.90459193
119MP0002095_abnormal_skin_pigmentation0.89907592
120MP0003937_abnormal_limbs/digits/tail_de0.89855662
121MP0000465_gastrointestinal_hemorrhage0.87881260
122MP0002249_abnormal_larynx_morphology0.87839788
123MP0002938_white_spotting0.87601875
124MP0001485_abnormal_pinna_reflex0.86272749
125MP0003436_decreased_susceptibility_to0.84612589
126MP0000762_abnormal_tongue_morphology0.84423638
127MP0001119_abnormal_female_reproductive0.83525567
128MP0001216_abnormal_epidermal_layer0.81327562
129MP0002060_abnormal_skin_morphology0.81121740
130MP0005253_abnormal_eye_physiology0.80832689
131MP0002723_abnormal_immune_serum0.79589809
132MP0005551_abnormal_eye_electrophysiolog0.78096185
133MP0002282_abnormal_trachea_morphology0.77971001
134MP0000477_abnormal_intestine_morphology0.77929641
135MP0003448_altered_tumor_morphology0.77263794
136MP0002111_abnormal_tail_morphology0.75768432
137MP0005000_abnormal_immune_tolerance0.74952437
138MP0003121_genomic_imprinting0.74513469
139MP0005275_abnormal_skin_tensile0.74305725
140MP0001873_stomach_inflammation0.73701421
141MP0009785_altered_susceptibility_to0.73383845
142MP0003453_abnormal_keratinocyte_physiol0.72957736
143MP0000377_abnormal_hair_follicle0.72674844
144MP0000750_abnormal_muscle_regeneration0.72338136
145MP0005025_abnormal_response_to0.72078161
146MP0000733_abnormal_muscle_development0.71592987
147MP0003878_abnormal_ear_physiology0.69489358
148MP0005377_hearing/vestibular/ear_phenot0.69489358
149MP0003186_abnormal_redox_activity0.68707199
150MP0004947_skin_inflammation0.68648652
151MP0000358_abnormal_cell_content/0.68026031
152MP0001915_intracranial_hemorrhage0.67803864
153MP0001286_abnormal_eye_development0.66808676
154MP0002098_abnormal_vibrissa_morphology0.66088153
155MP0009931_abnormal_skin_appearance0.65924819
156MP0008877_abnormal_DNA_methylation0.65675695
157MP0005410_abnormal_fertilization0.64916558
158MP0002127_abnormal_cardiovascular_syste0.64560893
159MP0005408_hypopigmentation0.62765976
160MP0000566_synostosis0.62146648
161MP0005332_abnormal_amino_acid0.60801186
162MP0003698_abnormal_male_reproductive0.59650255
163MP0008875_abnormal_xenobiotic_pharmacok0.59410643
164MP0002138_abnormal_hepatobiliary_system0.58991795
165MP0008789_abnormal_olfactory_epithelium0.58443262
166MP0001968_abnormal_touch/_nociception0.57195963

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.70021685
2Reticulocytopenia (HP:0001896)7.26743299
3Abnormal number of erythroid precursors (HP:0012131)6.82682202
4Acute necrotizing encephalopathy (HP:0006965)5.09505158
5Mitochondrial inheritance (HP:0001427)5.05601968
6Macrocytic anemia (HP:0001972)4.97213258
7Abnormal mitochondria in muscle tissue (HP:0008316)4.86100330
8Pallor (HP:0000980)4.77228731
9Increased hepatocellular lipid droplets (HP:0006565)4.68493404
10Hepatocellular necrosis (HP:0001404)4.50364826
11Increased CSF lactate (HP:0002490)4.38851200
12Acute encephalopathy (HP:0006846)4.34094306
13Lipid accumulation in hepatocytes (HP:0006561)4.29138426
14Progressive macrocephaly (HP:0004481)4.22246998
15Hepatic necrosis (HP:0002605)4.09340826
16Colon cancer (HP:0003003)4.02996249
17Renal Fanconi syndrome (HP:0001994)3.96733937
18Thrombocytosis (HP:0001894)3.74288581
19Increased intramyocellular lipid droplets (HP:0012240)3.72270228
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.64242678
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.64242678
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.42071190
233-Methylglutaconic aciduria (HP:0003535)3.40495172
2411 pairs of ribs (HP:0000878)3.28059079
25Exertional dyspnea (HP:0002875)3.20716273
26Cerebral edema (HP:0002181)3.19381483
27Increased muscle lipid content (HP:0009058)3.14659811
28Aplastic anemia (HP:0001915)3.10903995
29Selective tooth agenesis (HP:0001592)3.00816287
30Oral leukoplakia (HP:0002745)2.95827259
31Absent thumb (HP:0009777)2.95694122
32Increased serum lactate (HP:0002151)2.88719922
33Lactic acidosis (HP:0003128)2.87800797
34Multiple enchondromatosis (HP:0005701)2.86369598
35Birth length less than 3rd percentile (HP:0003561)2.83038753
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78475039
37Trismus (HP:0000211)2.76962780
38Respiratory difficulties (HP:0002880)2.69030690
39Respiratory failure (HP:0002878)2.67604111
40Exercise intolerance (HP:0003546)2.67235078
41Abnormality of reticulocytes (HP:0004312)2.61468653
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.61371172
43Abnormal hemoglobin (HP:0011902)2.55634217
44Abnormality of renal resorption (HP:0011038)2.48677101
45Missing ribs (HP:0000921)2.48281571
46Pancytopenia (HP:0001876)2.40990687
47Type I transferrin isoform profile (HP:0003642)2.40898741
48Optic disc pallor (HP:0000543)2.38429183
49Stenosis of the external auditory canal (HP:0000402)2.33694269
50Myelodysplasia (HP:0002863)2.32865946
51Leukodystrophy (HP:0002415)2.30967944
52Depressed nasal ridge (HP:0000457)2.30696725
53Septo-optic dysplasia (HP:0100842)2.29247612
54Breast hypoplasia (HP:0003187)2.27607800
55Glycosuria (HP:0003076)2.26426064
56Abnormality of urine glucose concentration (HP:0011016)2.26426064
57Pancreatic cysts (HP:0001737)2.26384873
58Carpal bone hypoplasia (HP:0001498)2.25884577
59Rough bone trabeculation (HP:0100670)2.25260123
60IgM deficiency (HP:0002850)2.24174507
61Basal cell carcinoma (HP:0002671)2.23583603
62Atresia of the external auditory canal (HP:0000413)2.19193516
63Neoplasm of the pancreas (HP:0002894)2.17964124
64Patellar aplasia (HP:0006443)2.14454751
65Glossoptosis (HP:0000162)2.13359957
66Ependymoma (HP:0002888)2.10212067
67Abnormal number of incisors (HP:0011064)2.09785153
68Generalized aminoaciduria (HP:0002909)2.08793657
69Sclerocornea (HP:0000647)2.08688805
70Microretrognathia (HP:0000308)2.07525273
71Chromsome breakage (HP:0040012)2.07294856
72Pancreatic fibrosis (HP:0100732)2.05133671
73Lethargy (HP:0001254)2.04871912
74Medulloblastoma (HP:0002885)2.04585448
75Aplasia/Hypoplasia of the patella (HP:0006498)2.03504142
76Asplenia (HP:0001746)2.02907066
77Premature graying of hair (HP:0002216)2.01764095
78Abnormality of the anterior horn cell (HP:0006802)1.99425620
79Degeneration of anterior horn cells (HP:0002398)1.99425620
80Thick lower lip vermilion (HP:0000179)1.98931241
81True hermaphroditism (HP:0010459)1.96011252
82Deviation of the thumb (HP:0009603)1.95597796
83Aplasia/hypoplasia of the uterus (HP:0008684)1.95210986
84Proximal placement of thumb (HP:0009623)1.95088596
85Hypoplasia of the radius (HP:0002984)1.95051622
86Abnormality of the preputium (HP:0100587)1.93983000
87Concave nail (HP:0001598)1.92542605
88Methylmalonic acidemia (HP:0002912)1.89863701
89Congenital, generalized hypertrichosis (HP:0004540)1.89564055
90Meckel diverticulum (HP:0002245)1.89252606
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.89106632
92Lymphoma (HP:0002665)1.88734477
93Abnormality of the renal collecting system (HP:0004742)1.88332434
94Triphalangeal thumb (HP:0001199)1.88119438
95Hyperphosphaturia (HP:0003109)1.87742575
96Abnormal protein glycosylation (HP:0012346)1.87205565
97Abnormal glycosylation (HP:0012345)1.87205565
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87205565
99Abnormal protein N-linked glycosylation (HP:0012347)1.87205565
100Reduced antithrombin III activity (HP:0001976)1.86963770
101Squamous cell carcinoma (HP:0002860)1.86806586
102Poikiloderma (HP:0001029)1.86280324
103Duplicated collecting system (HP:0000081)1.85926060
104Agnosia (HP:0010524)1.84368169
105Amaurosis fugax (HP:0100576)1.83096042
106Abnormality of the pons (HP:0007361)1.81735899
107Abnormality of chromosome stability (HP:0003220)1.80255518
108Neoplasm of the colon (HP:0100273)1.79924011
109Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79720729
110Abnormality of the ileum (HP:0001549)1.79108996
111Tracheoesophageal fistula (HP:0002575)1.78854945
112Abnormality of methionine metabolism (HP:0010901)1.78737298
113Cellular immunodeficiency (HP:0005374)1.78360608
114Migraine (HP:0002076)1.76524083
115Methylmalonic aciduria (HP:0012120)1.76342556
116Cleft eyelid (HP:0000625)1.75818276
117Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73588758
118Sparse lateral eyebrow (HP:0005338)1.72264431
119Hypoplasia of the uterus (HP:0000013)1.72068827
120Hypoplasia of the pons (HP:0012110)1.71825936
121Microvesicular hepatic steatosis (HP:0001414)1.71119963
122CNS demyelination (HP:0007305)1.69296070
123Bicuspid aortic valve (HP:0001647)1.68000961
124Megaloblastic anemia (HP:0001889)1.66942521
125Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66515684
126Woolly hair (HP:0002224)1.66364709
127Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.64140799
128Vertebral hypoplasia (HP:0008417)1.64140799
129Rhabdomyosarcoma (HP:0002859)1.63956485
130Premature ovarian failure (HP:0008209)1.62573833
131Abnormality of the parietal bone (HP:0002696)1.62141077
132Partial duplication of the phalanx of hand (HP:0009999)1.61808399
133Bilateral microphthalmos (HP:0007633)1.61331355
134Ankle contracture (HP:0006466)1.60543538
135Rectal prolapse (HP:0002035)1.60330304
136Elevated erythrocyte sedimentation rate (HP:0003565)1.59774845
137Chromosomal breakage induced by crosslinking agents (HP:0003221)1.58555369
138Increased nuchal translucency (HP:0010880)1.58497628
139Abnormality of T cells (HP:0002843)1.58431865
140Absent radius (HP:0003974)1.58068991
141Bone marrow hypocellularity (HP:0005528)1.57944295
142Abnormal lung lobation (HP:0002101)1.57451374
143Biliary tract neoplasm (HP:0100574)1.57077646
144Increased density of long bones (HP:0006392)1.57026952
145Absent septum pellucidum (HP:0001331)1.56764386
146Abnormality of the calcaneus (HP:0008364)1.56443116
147Maternal diabetes (HP:0009800)1.56434896
148Abnormality of midbrain morphology (HP:0002418)1.56002641
149Molar tooth sign on MRI (HP:0002419)1.56002641
150Small intestinal stenosis (HP:0012848)1.55868588
151Duodenal stenosis (HP:0100867)1.55868588
152Horseshoe kidney (HP:0000085)1.55569421
153Abnormal trabecular bone morphology (HP:0100671)1.55393983
154Sparse eyelashes (HP:0000653)1.54592479
155Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.54522796
156Recurrent bronchitis (HP:0002837)1.54511772
157Neutropenia (HP:0001875)1.54457412
158Abnormality of T cell physiology (HP:0011840)1.54197475
159Hypoplastic left heart (HP:0004383)1.53975935
160Blepharitis (HP:0000498)1.53936543
161Preauricular skin tag (HP:0000384)1.53629739
162Renal cortical cysts (HP:0000803)1.52773373
163Partial duplication of thumb phalanx (HP:0009944)1.52759825
164Optic nerve coloboma (HP:0000588)1.51985022
165Emotional lability (HP:0000712)1.51812342
166Short thumb (HP:0009778)1.50518950
167Petechiae (HP:0000967)1.49399676
168Aplasia/Hypoplasia of the uvula (HP:0010293)1.49279076
169Skin tags (HP:0010609)1.48839783
170Aplasia/Hypoplasia of the thymus (HP:0010515)1.48611373
171Recurrent viral infections (HP:0004429)1.47643149
172Angiofibromas (HP:0010615)1.47586090
173Adenoma sebaceum (HP:0009720)1.47586090
174T lymphocytopenia (HP:0005403)1.46535709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.08584774
2NME24.16776923
3WEE13.15697297
4BUB13.03977508
5CDC72.93486308
6EEF2K2.88075418
7TAF12.78164628
8RPS6KB22.68594228
9NEK22.29787880
10LRRK22.26055252
11EIF2AK12.19671157
12NUAK12.19082525
13TAOK32.17687050
14PASK1.94769901
15SRPK11.94235849
16TGFBR11.90441072
17TLK11.87742639
18MAP4K11.78944996
19MAP3K101.71901744
20BCKDK1.70713046
21PIM21.69742126
22PKN21.69548703
23RPS6KA41.64676582
24PBK1.63509155
25AURKB1.59459986
26STK101.59091042
27MKNK11.56381820
28CDK71.55815922
29NEK11.53711571
30ACVR1B1.53613776
31VRK11.52401959
32TSSK61.52181809
33BRSK21.51240127
34DYRK31.49964198
35MST41.46087574
36TTK1.39638678
37CDK121.38968240
38TESK21.37724749
39EPHA21.33577320
40PLK11.33533832
41MAP3K121.30308299
42PAK41.29064420
43CDK41.28286348
44STK161.28160151
45FLT31.27841199
46EIF2AK31.27158592
47SCYL21.26692983
48ATR1.26060026
49MAP3K81.23429480
50PIM11.19387098
51ADRBK21.19189053
52ILK1.16152926
53CDK191.14620506
54GRK11.10994454
55PLK41.06114161
56STK41.05420926
57MAPKAPK31.02130707
58BTK1.01006944
59MAP4K21.00836839
60CDK60.93787015
61INSRR0.93637065
62MAP2K30.93270800
63CHEK10.90478346
64DYRK20.89937463
65DAPK30.88024465
66BMPR1B0.87940348
67AURKA0.87072192
68PDK20.84490686
69TRIB30.82273165
70CHEK20.81270058
71ZAP700.80983570
72MUSK0.80979771
73MAP3K30.79041167
74MKNK20.78982373
75PLK30.78769956
76TEC0.77803377
77PAK20.74355197
78JAK30.74249378
79CSNK2A20.74026463
80TNIK0.73880914
81DAPK10.72806744
82KDR0.72592955
83TESK10.67623556
84PAK10.66875052
85ATM0.65350334
86BRSK10.65121170
87ABL20.64769584
88WNK30.64068668
89ALK0.63476714
90GRK60.62565968
91MAPK150.62262916
92GRK50.61132667
93BRD40.61041194
94CDK20.60595233
95RPS6KA50.59812161
96TYK20.58620940
97CLK10.58561764
98CSNK2A10.58510784
99BLK0.58070006
100CDK80.57238732
101IKBKB0.56722409
102MAPKAPK50.56607252
103NLK0.55165244
104CCNB10.53935467
105KIT0.52597876
106PRKCI0.48981345
107CSNK1G10.47319918
108SMG10.47173901
109CSF1R0.46626734
110CSNK1G30.45889370
111MELK0.45346920
112ZAK0.44546709
113ADRBK10.44137636
114ITK0.43625536
115STK30.41347575
116CDK30.40952583
117MAPKAPK20.40884950
118CHUK0.40426247
119LCK0.39978179
120RPS6KL10.39459543
121RPS6KC10.39459543
122SYK0.39253753
123IKBKE0.39200108
124RPS6KA60.37897159
125GRK70.37527721
126OXSR10.37338924
127LYN0.37141912
128MTOR0.36752588
129TXK0.36207512
130CDK10.35907621
131NEK90.35205263
132TTN0.35055851
133EIF2AK20.35052022
134NME10.34782096
135MAP3K110.33591572
136WNK40.29645008
137PRKCQ0.27188702
138MYLK0.26881080
139OBSCN0.20315139

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.43487811
2DNA replication_Homo sapiens_hsa030304.19363828
3Mismatch repair_Homo sapiens_hsa034303.50710151
4Spliceosome_Homo sapiens_hsa030403.19386123
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94116119
6RNA polymerase_Homo sapiens_hsa030202.83024399
7Proteasome_Homo sapiens_hsa030502.82205809
8Alzheimers disease_Homo sapiens_hsa050102.71964883
9RNA transport_Homo sapiens_hsa030132.62756871
10Base excision repair_Homo sapiens_hsa034102.53730362
11Nucleotide excision repair_Homo sapiens_hsa034202.46839273
12Homologous recombination_Homo sapiens_hsa034402.43818311
13Pyrimidine metabolism_Homo sapiens_hsa002402.14117319
14One carbon pool by folate_Homo sapiens_hsa006702.13785490
15Cell cycle_Homo sapiens_hsa041102.10373955
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88835565
17Non-homologous end-joining_Homo sapiens_hsa034501.87248849
18Cardiac muscle contraction_Homo sapiens_hsa042601.86112200
19RNA degradation_Homo sapiens_hsa030181.68904581
20Fanconi anemia pathway_Homo sapiens_hsa034601.62505407
21p53 signaling pathway_Homo sapiens_hsa041151.56951986
22mRNA surveillance pathway_Homo sapiens_hsa030151.46368283
23Basal transcription factors_Homo sapiens_hsa030221.36320976
24Antigen processing and presentation_Homo sapiens_hsa046121.31419660
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26745634
26Primary immunodeficiency_Homo sapiens_hsa053401.26625325
27Epstein-Barr virus infection_Homo sapiens_hsa051691.18843684
28Systemic lupus erythematosus_Homo sapiens_hsa053221.18491041
29Herpes simplex infection_Homo sapiens_hsa051681.10818424
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07958760
31Protein export_Homo sapiens_hsa030601.02652876
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01721305
33Viral carcinogenesis_Homo sapiens_hsa052030.97126306
34Purine metabolism_Homo sapiens_hsa002300.93572856
35HTLV-I infection_Homo sapiens_hsa051660.91625931
36Small cell lung cancer_Homo sapiens_hsa052220.88879496
37Maturity onset diabetes of the young_Homo sapiens_hsa049500.86341298
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86282470
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85360643
40Thyroid cancer_Homo sapiens_hsa052160.80923989
41Sulfur metabolism_Homo sapiens_hsa009200.80816237
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.80391919
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77018662
44Autoimmune thyroid disease_Homo sapiens_hsa053200.76327312
45Legionellosis_Homo sapiens_hsa051340.76262162
46Hematopoietic cell lineage_Homo sapiens_hsa046400.72220132
47Measles_Homo sapiens_hsa051620.71757002
48MicroRNAs in cancer_Homo sapiens_hsa052060.69860708
49Parkinsons disease_Homo sapiens_hsa050120.68962406
50Metabolic pathways_Homo sapiens_hsa011000.68492600
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.68424952
52Huntingtons disease_Homo sapiens_hsa050160.68238797
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67047725
54Apoptosis_Homo sapiens_hsa042100.65923713
55Pentose phosphate pathway_Homo sapiens_hsa000300.65111117
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63510648
57Pyruvate metabolism_Homo sapiens_hsa006200.63298694
58Chronic myeloid leukemia_Homo sapiens_hsa052200.62868241
59Basal cell carcinoma_Homo sapiens_hsa052170.62161197
60Nitrogen metabolism_Homo sapiens_hsa009100.61827297
61Sulfur relay system_Homo sapiens_hsa041220.60812425
62Acute myeloid leukemia_Homo sapiens_hsa052210.59367365
63Vitamin digestion and absorption_Homo sapiens_hsa049770.59210016
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58365915
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.55405221
66TGF-beta signaling pathway_Homo sapiens_hsa043500.54668783
67Viral myocarditis_Homo sapiens_hsa054160.54439252
68Type I diabetes mellitus_Homo sapiens_hsa049400.54051603
69Notch signaling pathway_Homo sapiens_hsa043300.52821433
70Hepatitis B_Homo sapiens_hsa051610.52685703
71Propanoate metabolism_Homo sapiens_hsa006400.51897618
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51860207
73Phototransduction_Homo sapiens_hsa047440.50965914
74Shigellosis_Homo sapiens_hsa051310.50444020
75Peroxisome_Homo sapiens_hsa041460.49484977
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49484383
77Fatty acid elongation_Homo sapiens_hsa000620.48589096
78Bladder cancer_Homo sapiens_hsa052190.48063485
79Colorectal cancer_Homo sapiens_hsa052100.47023340
80Leishmaniasis_Homo sapiens_hsa051400.47016814
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46814743
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46469008
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.46350680
84Chemical carcinogenesis_Homo sapiens_hsa052040.46090000
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.45907019
86Hippo signaling pathway_Homo sapiens_hsa043900.45785195
87B cell receptor signaling pathway_Homo sapiens_hsa046620.44252637
88N-Glycan biosynthesis_Homo sapiens_hsa005100.44202728
89Glutathione metabolism_Homo sapiens_hsa004800.43453620
90Pathways in cancer_Homo sapiens_hsa052000.43109471
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43069203
92Linoleic acid metabolism_Homo sapiens_hsa005910.42365089
93Oxidative phosphorylation_Homo sapiens_hsa001900.41707448
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41448311
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41259544
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40694071
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39983623
98Folate biosynthesis_Homo sapiens_hsa007900.39313374
99HIF-1 signaling pathway_Homo sapiens_hsa040660.39234284
100Adherens junction_Homo sapiens_hsa045200.39129482
101Allograft rejection_Homo sapiens_hsa053300.38829781
102T cell receptor signaling pathway_Homo sapiens_hsa046600.38686764
103Toxoplasmosis_Homo sapiens_hsa051450.38431699
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38145886
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38080067
106Caffeine metabolism_Homo sapiens_hsa002320.37793131
107Influenza A_Homo sapiens_hsa051640.37758490
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37012793
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.36595323
110Proteoglycans in cancer_Homo sapiens_hsa052050.36418409
111Oocyte meiosis_Homo sapiens_hsa041140.34986397
112Asthma_Homo sapiens_hsa053100.34213697
113Biosynthesis of amino acids_Homo sapiens_hsa012300.34038816
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33965223
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33483938
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32911270
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32833360
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32421764
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32237144
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31730953
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30541555
122Alcoholism_Homo sapiens_hsa050340.30508788
123Graft-versus-host disease_Homo sapiens_hsa053320.30235856
124Selenocompound metabolism_Homo sapiens_hsa004500.30059542
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29435179
126Regulation of autophagy_Homo sapiens_hsa041400.29166468
127Arachidonic acid metabolism_Homo sapiens_hsa005900.28369377
128Hedgehog signaling pathway_Homo sapiens_hsa043400.28278232
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28265459
130Prostate cancer_Homo sapiens_hsa052150.27920798
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24977798
132ECM-receptor interaction_Homo sapiens_hsa045120.24627329
133Non-small cell lung cancer_Homo sapiens_hsa052230.24450250
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.24299924
135Tyrosine metabolism_Homo sapiens_hsa003500.23565615
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21210433
137Olfactory transduction_Homo sapiens_hsa047400.20383571
138Rheumatoid arthritis_Homo sapiens_hsa053230.20331882
139Tryptophan metabolism_Homo sapiens_hsa003800.19632287
140Collecting duct acid secretion_Homo sapiens_hsa049660.19516434
141Retinol metabolism_Homo sapiens_hsa008300.18942882
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.16266294
143Butanoate metabolism_Homo sapiens_hsa006500.14862642
144Carbon metabolism_Homo sapiens_hsa012000.13714520
145Fat digestion and absorption_Homo sapiens_hsa049750.10540555

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