RPL23AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.27464274
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.11755715
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.04676381
4melanin biosynthetic process (GO:0042438)5.02976650
5melanin metabolic process (GO:0006582)4.90976469
6antigen processing and presentation of endogenous antigen (GO:0019883)4.86800400
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.75906162
8T cell migration (GO:0072678)4.56518098
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.45996151
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.30586217
11negative regulation of cell killing (GO:0031342)4.30586217
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.28654568
13secondary metabolite biosynthetic process (GO:0044550)4.26654273
14regulation of B cell receptor signaling pathway (GO:0050855)4.24916803
15response to peptidoglycan (GO:0032494)3.86233546
16regulation of gamma-delta T cell activation (GO:0046643)3.85419524
17mast cell activation (GO:0045576)3.64737160
18regulation of gamma-delta T cell differentiation (GO:0045586)3.63654367
19immunoglobulin mediated immune response (GO:0016064)3.54883983
20negative T cell selection (GO:0043383)3.52985749
21regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.45913086
22response to type I interferon (GO:0034340)3.40959953
23cellular response to interleukin-15 (GO:0071350)3.38357174
24B cell receptor signaling pathway (GO:0050853)3.37974113
25cellular response to type I interferon (GO:0071357)3.37872021
26type I interferon signaling pathway (GO:0060337)3.37872021
27thymic T cell selection (GO:0045061)3.34259519
28regulation of B cell differentiation (GO:0045577)3.31749228
29positive regulation of T cell mediated cytotoxicity (GO:0001916)3.30357137
30T cell selection (GO:0045058)3.29191410
31positive T cell selection (GO:0043368)3.26162381
32positive thymic T cell selection (GO:0045059)3.25952069
33regulation of T cell mediated cytotoxicity (GO:0001914)3.20784987
34response to interleukin-15 (GO:0070672)3.20064201
35regulation of alpha-beta T cell proliferation (GO:0046640)3.20049531
36negative regulation of interleukin-12 production (GO:0032695)3.19774802
37regulation of interleukin-2 biosynthetic process (GO:0045076)3.17337521
38positive regulation of tolerance induction (GO:0002645)3.15164206
39negative thymic T cell selection (GO:0045060)3.14475833
40positive regulation of granulocyte differentiation (GO:0030854)3.12065136
41positive regulation of interleukin-2 production (GO:0032743)3.11994671
42positive regulation of B cell differentiation (GO:0045579)3.11240557
43positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.08351315
44regulation of regulatory T cell differentiation (GO:0045589)3.07965234
45interferon-gamma-mediated signaling pathway (GO:0060333)3.05866282
46regulation of T cell tolerance induction (GO:0002664)3.03591848
47cellular response to zinc ion (GO:0071294)3.03234769
48B cell mediated immunity (GO:0019724)3.03221487
49negative regulation of T cell apoptotic process (GO:0070233)3.02622161
50positive regulation by symbiont of host defense response (GO:0052509)3.01900091
51modulation by symbiont of host defense response (GO:0052031)3.01900091
52modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01900091
53modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01900091
54positive regulation by organism of defense response of other organism involved in symbiotic interact3.01900091
55modulation by symbiont of host immune response (GO:0052553)3.01900091
56regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.00482544
57detection of other organism (GO:0098543)2.98273671
58positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97627950
59antigen receptor-mediated signaling pathway (GO:0050851)2.97547635
60antigen processing and presentation via MHC class Ib (GO:0002475)2.96555248
61regulation of antigen processing and presentation (GO:0002577)2.96392405
62neutrophil activation involved in immune response (GO:0002283)2.95367561
63defense response to protozoan (GO:0042832)2.94913142
64interferon-gamma production (GO:0032609)2.94440630
65regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.93951899
66leukocyte aggregation (GO:0070486)2.93775578
67response to interferon-alpha (GO:0035455)2.93327431
68microglial cell activation (GO:0001774)2.93030977
69regulation of tolerance induction (GO:0002643)2.92367377
70detection of bacterium (GO:0016045)2.92318983
71NIK/NF-kappaB signaling (GO:0038061)2.89251832
72lymphocyte migration (GO:0072676)2.88730397
73negative regulation of execution phase of apoptosis (GO:1900118)2.88695354
74leukocyte degranulation (GO:0043299)2.86933954
75T cell receptor signaling pathway (GO:0050852)2.86904340
76mast cell activation involved in immune response (GO:0002279)2.86597671
77mast cell degranulation (GO:0043303)2.86597671
78positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.86513180
79DNA deamination (GO:0045006)2.83142435
80response to interferon-beta (GO:0035456)2.82668250
81regulation of interferon-beta biosynthetic process (GO:0045357)2.79563878
82regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79494214
83lymphocyte chemotaxis (GO:0048247)2.79438774
84tolerance induction (GO:0002507)2.75480113
85regulation of mast cell degranulation (GO:0043304)2.73520180
86macrophage activation involved in immune response (GO:0002281)2.73477104
87negative regulation of interleukin-1 beta production (GO:0032691)2.72966706
88myeloid cell activation involved in immune response (GO:0002275)2.71112516
89regulation of alpha-beta T cell activation (GO:0046634)2.69500816
90negative regulation of lymphocyte mediated immunity (GO:0002707)2.69393595
91negative regulation of T cell mediated immunity (GO:0002710)2.67574989
92response to protozoan (GO:0001562)2.66500343
93positive regulation of antigen processing and presentation (GO:0002579)2.65793048
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.64288145
95cytokine biosynthetic process (GO:0042089)2.63548593
96positive regulation of T cell mediated immunity (GO:0002711)2.61705705
97negative regulation of interleukin-1 production (GO:0032692)2.60201686
98positive regulation of defense response to virus by host (GO:0002230)2.58844472
99regulation of autophagic vacuole assembly (GO:2000785)2.58272128
100negative regulation of innate immune response (GO:0045824)2.58163604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.57379784
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.59691284
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.38704049
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.26745239
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.96354580
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.38651476
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.37814239
8MYB_26560356_Chip-Seq_TH2_Human2.80247705
9RUNX_20019798_ChIP-Seq_JUKART_Human2.73734152
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.70668252
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.69671785
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.66104246
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53203361
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.47335716
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46991312
16SPI1_23547873_ChIP-Seq_NB4_Human2.38299854
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.37736964
18MYB_26560356_Chip-Seq_TH1_Human2.34912210
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29450959
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23046817
21MAF_26560356_Chip-Seq_TH1_Human2.08228913
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06085718
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05719841
24GATA3_27048872_Chip-Seq_THYMUS_Human2.02381918
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96525833
26GATA3_26560356_Chip-Seq_TH2_Human1.95392503
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88506681
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.88176001
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.85046126
30UTX_26944678_Chip-Seq_JUKART_Human1.78286529
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76832000
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76513691
33SPI1_23127762_ChIP-Seq_K562_Human1.75529670
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72875163
35VDR_24787735_ChIP-Seq_THP-1_Human1.70173858
36MAF_26560356_Chip-Seq_TH2_Human1.68031983
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66315730
38SCL_19346495_ChIP-Seq_HPC-7_Human1.66308862
39VDR_24763502_ChIP-Seq_THP-1_Human1.66275195
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62156768
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56431640
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52551342
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.45702812
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38792733
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.38641457
46VDR_23849224_ChIP-Seq_CD4+_Human1.36326129
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36023656
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32773644
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31812590
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.30341847
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.26766937
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23830182
53CIITA_25753668_ChIP-Seq_RAJI_Human1.23680318
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22684577
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22315055
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21743428
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.11616821
58MYC_22102868_ChIP-Seq_BL_Human1.10773745
59VDR_21846776_ChIP-Seq_THP-1_Human1.10697139
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10293440
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10042729
62BCL6_27268052_Chip-Seq_Bcells_Human1.09625973
63FOXP3_21729870_ChIP-Seq_TREG_Human1.09361841
64STAT1_20625510_ChIP-Seq_HELA_Human1.08213036
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05980955
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05314468
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01976429
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01252775
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00816623
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00216154
71IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99521149
72NANOG_20526341_ChIP-Seq_ESCs_Human0.98089190
73GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97785055
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97369186
75GATA1_22025678_ChIP-Seq_K562_Human0.97187499
76IGF1R_20145208_ChIP-Seq_DFB_Human0.96668647
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95920333
78GATA3_26560356_Chip-Seq_TH1_Human0.95831715
79P300_27268052_Chip-Seq_Bcells_Human0.94966523
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94379385
81SRF_21415370_ChIP-Seq_HL-1_Mouse0.93079139
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92963298
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92831373
84SPI1_20517297_ChIP-Seq_HL60_Human0.92697642
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92024110
86ELF1_20517297_ChIP-Seq_JURKAT_Human0.90475594
87GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90461947
88BCOR_27268052_Chip-Seq_Bcells_Human0.90407481
89EST1_17652178_ChIP-ChIP_JURKAT_Human0.89952832
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89161233
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87756049
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87515245
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86772480
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86281543
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85669454
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85658819
97PU_27001747_Chip-Seq_BMDM_Mouse0.85656915
98TFEB_21752829_ChIP-Seq_HELA_Human0.85498873
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83488473
100SMRT_27268052_Chip-Seq_Bcells_Human0.83001439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.09247865
2MP0001835_abnormal_antigen_presentation3.82518087
3MP0005075_abnormal_melanosome_morpholog3.82422847
4MP0000372_irregular_coat_pigmentation3.76596827
5MP0005671_abnormal_response_to3.61372891
6MP0003724_increased_susceptibility_to3.33343216
7MP0004381_abnormal_hair_follicle3.05997963
8MP0005387_immune_system_phenotype2.91591564
9MP0001790_abnormal_immune_system2.91591564
10MP0009785_altered_susceptibility_to2.88223540
11MP0003763_abnormal_thymus_physiology2.80687623
12MP0001800_abnormal_humoral_immune2.73184307
13MP0003436_decreased_susceptibility_to2.67938282
14MP0005000_abnormal_immune_tolerance2.52006916
15MP0000685_abnormal_immune_system2.38967933
16MP0002148_abnormal_hypersensitivity_rea2.30283466
17MP0002723_abnormal_immune_serum2.30161545
18MP0005025_abnormal_response_to2.28997713
19MP0002420_abnormal_adaptive_immunity2.25463980
20MP0002452_abnormal_antigen_presenting2.25244004
21MP0002419_abnormal_innate_immunity2.22624969
22MP0005408_hypopigmentation2.22170110
23MP0001819_abnormal_immune_cell2.21286115
24MP0002132_abnormal_respiratory_system2.09541247
25MP0002138_abnormal_hepatobiliary_system1.99537440
26MP0003303_peritoneal_inflammation1.97091450
27MP0006082_CNS_inflammation1.84651009
28MP0000015_abnormal_ear_pigmentation1.82287309
29MP0002166_altered_tumor_susceptibility1.77009044
30MP0002398_abnormal_bone_marrow1.74734989
31MP0002405_respiratory_system_inflammati1.73634716
32MP0003646_muscle_fatigue1.71727383
33MP0008004_abnormal_stomach_pH1.70951537
34MP0000716_abnormal_immune_system1.66122323
35MP0010155_abnormal_intestine_physiology1.55261134
36MP0005464_abnormal_platelet_physiology1.53162357
37MP0001845_abnormal_inflammatory_respons1.53025271
38MP0000371_diluted_coat_color1.48334075
39MP0000689_abnormal_spleen_morphology1.44015958
40MP0005171_absent_coat_pigmentation1.42496218
41MP0002722_abnormal_immune_system1.42418790
42MP0003172_abnormal_lysosome_physiology1.39550670
43MP0002095_abnormal_skin_pigmentation1.39159605
44MP0000703_abnormal_thymus_morphology1.38978111
45MP0001533_abnormal_skeleton_physiology1.36567448
46MP0002429_abnormal_blood_cell1.36198047
47MP0004947_skin_inflammation1.34554222
48MP0002006_tumorigenesis1.34501071
49MP0009333_abnormal_splenocyte_physiolog1.29602964
50MP0003136_yellow_coat_color1.26937289
51MP0002102_abnormal_ear_morphology1.22793401
52MP0008469_abnormal_protein_level1.22338688
53MP0005166_decreased_susceptibility_to1.21508026
54MP0005174_abnormal_tail_pigmentation1.19168617
55MP0003866_abnormal_defecation1.16881893
56MP0005377_hearing/vestibular/ear_phenot1.15998545
57MP0003878_abnormal_ear_physiology1.15998545
58MP0002277_abnormal_respiratory_mucosa1.08434794
59MP0001853_heart_inflammation1.08286081
60MP0009764_decreased_sensitivity_to1.07324966
61MP0003045_fibrosis1.05918231
62MP0003300_gastrointestinal_ulcer1.04844154
63MP0006036_abnormal_mitochondrial_physio1.03569427
64MP0002396_abnormal_hematopoietic_system0.98654757
65MP0001545_abnormal_hematopoietic_system0.92147182
66MP0005397_hematopoietic_system_phenotyp0.92147182
67MP0001873_stomach_inflammation0.90235393
68MP0005310_abnormal_salivary_gland0.88373899
69MP0002998_abnormal_bone_remodeling0.87285769
70MP0002163_abnormal_gland_morphology0.86744939
71MP0000465_gastrointestinal_hemorrhage0.86094112
72MP0003656_abnormal_erythrocyte_physiolo0.85326135
73MP0001851_eye_inflammation0.84616108
74MP0006054_spinal_hemorrhage0.83552852
75MP0003786_premature_aging0.82455661
76MP0003075_altered_response_to0.80958343
77MP0003448_altered_tumor_morphology0.78259320
78MP0003828_pulmonary_edema0.77319919
79MP0000343_altered_response_to0.76427676
80MP0001324_abnormal_eye_pigmentation0.75993095
81MP0005058_abnormal_lysosome_morphology0.73575637
82MP0004484_altered_response_of0.72162825
83MP0009763_increased_sensitivity_to0.71874244
84MP0002019_abnormal_tumor_incidence0.69139740
85MP0002090_abnormal_vision0.66280361
86MP0000858_altered_metastatic_potential0.66254771
87MP0002254_reproductive_system_inflammat0.64410811
88MP0004808_abnormal_hematopoietic_stem0.63312736
89MP0004510_myositis0.61646330
90MP0002933_joint_inflammation0.60948196
91MP0001764_abnormal_homeostasis0.58694243
92MP0003195_calcinosis0.58300025
93MP0005319_abnormal_enzyme/_coenzyme0.56420682
94MP0005164_abnormal_response_to0.55874326
95MP0003950_abnormal_plasma_membrane0.55695416
96MP0000678_abnormal_parathyroid_gland0.55684538
97MP0001663_abnormal_digestive_system0.54045495
98MP0005451_abnormal_body_composition0.53076762
99MP0008260_abnormal_autophagy0.51739352
100MP0004883_abnormal_blood_vessel0.50617784

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.93796344
2Stomatitis (HP:0010280)4.44381110
3T lymphocytopenia (HP:0005403)4.19009943
4Abnormality of T cell number (HP:0011839)4.08775715
5Ocular albinism (HP:0001107)3.99552542
6Abnormal delayed hypersensitivity skin test (HP:0002963)3.99038903
7Increased IgM level (HP:0003496)3.84308521
8Myositis (HP:0100614)3.82095251
9Optic neuritis (HP:0100653)3.56504833
10Retrobulbar optic neuritis (HP:0100654)3.56504833
11Recurrent bacterial skin infections (HP:0005406)3.53855705
12Iris hypopigmentation (HP:0007730)3.53109848
13Abnormality of T cells (HP:0002843)3.52117720
14Eosinophilia (HP:0001880)3.43649232
15Recurrent abscess formation (HP:0002722)3.41819899
16Orchitis (HP:0100796)3.35437827
17Recurrent cutaneous fungal infections (HP:0011370)3.29128125
18Chronic mucocutaneous candidiasis (HP:0002728)3.29128125
19Aplasia/Hypoplasia of the macula (HP:0008059)3.27431031
20IgM deficiency (HP:0002850)3.23531772
21IgG deficiency (HP:0004315)3.22455027
22Abnormality of macrophages (HP:0004311)3.20603058
23Autoimmune hemolytic anemia (HP:0001890)3.14248615
24Granulocytopenia (HP:0001913)3.13375351
25Vasculitis (HP:0002633)3.07402421
26Recurrent fungal infections (HP:0002841)3.07118202
27Recurrent viral infections (HP:0004429)3.05721797
28Aplasia/Hypoplasia affecting the retina (HP:0008061)3.02456660
29Abnormality of eosinophils (HP:0001879)3.01509226
30Gastrointestinal infarctions (HP:0005244)3.00852502
31Encephalitis (HP:0002383)2.96604720
32Abnormality of T cell physiology (HP:0011840)2.91865600
33Meningitis (HP:0001287)2.89246897
34Leukocytosis (HP:0001974)2.88161178
35Dyschromatopsia (HP:0007641)2.88148105
36Recurrent skin infections (HP:0001581)2.86795308
37Panhypogammaglobulinemia (HP:0003139)2.86587748
38Congenital stationary night blindness (HP:0007642)2.77432980
39Abnormality of glycolipid metabolism (HP:0010969)2.72553735
40Abnormality of liposaccharide metabolism (HP:0010968)2.72553735
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.72553735
42Keratoconjunctivitis sicca (HP:0001097)2.70364104
43Aplastic anemia (HP:0001915)2.66991316
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65833001
45Pustule (HP:0200039)2.63669478
46Pulmonary infiltrates (HP:0002113)2.58534156
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.58385994
48Hypoplasia of the fovea (HP:0007750)2.58385994
49Keratoconjunctivitis (HP:0001096)2.54660400
50Mediastinal lymphadenopathy (HP:0100721)2.54456295
51Lymphopenia (HP:0001888)2.51409745
52Inflammation of the large intestine (HP:0002037)2.50411289
53Colitis (HP:0002583)2.49442879
54Hemoptysis (HP:0002105)2.42716637
55Abnormality of B cell number (HP:0010975)2.40137407
56Recurrent bronchitis (HP:0002837)2.39580325
57Obstructive lung disease (HP:0006536)2.37927128
58Chronic obstructive pulmonary disease (HP:0006510)2.37927128
59Petechiae (HP:0000967)2.37733732
60Agammaglobulinemia (HP:0004432)2.37653603
61Severe combined immunodeficiency (HP:0004430)2.35763176
62Eczematoid dermatitis (HP:0000976)2.34935438
63Abnormality of cells of the lymphoid lineage (HP:0012140)2.34484709
64Gastrointestinal inflammation (HP:0004386)2.31555916
65Abnormality of the columella (HP:0009929)2.30558472
66Albinism (HP:0001022)2.28621651
67Chest pain (HP:0100749)2.27050338
68B lymphocytopenia (HP:0010976)2.26232170
69Prolonged bleeding time (HP:0003010)2.24621847
70Chronic diarrhea (HP:0002028)2.23121056
71Generalized hypopigmentation (HP:0007513)2.19744389
72Anorexia (HP:0002039)2.14948811
73Increased muscle lipid content (HP:0009058)2.14401707
74Decreased central vision (HP:0007663)2.13356011
75Abnormality of the fovea (HP:0000493)2.12032848
76Papilledema (HP:0001085)2.11659629
77Thyroiditis (HP:0100646)2.10788254
78Autoimmune thrombocytopenia (HP:0001973)2.09142667
79Clumsiness (HP:0002312)2.08847807
80IgA deficiency (HP:0002720)2.07483619
81Gangrene (HP:0100758)2.06901302
82Urticaria (HP:0001025)2.06844291
83Arterial thrombosis (HP:0004420)2.06251626
84Increased intramyocellular lipid droplets (HP:0012240)2.01956824
85Renal Fanconi syndrome (HP:0001994)2.01567893
86Abnormal rod and cone electroretinograms (HP:0008323)2.00442599
87Increased serum ferritin (HP:0003281)2.00259895
88Hypergammaglobulinemia (HP:0010702)1.98033586
89Cutaneous melanoma (HP:0012056)1.95112186
90Recurrent gram-negative bacterial infections (HP:0005420)1.92579176
91Spontaneous hematomas (HP:0007420)1.89136546
92Chronic otitis media (HP:0000389)1.87417563
93Combined immunodeficiency (HP:0005387)1.86686840
94Hematochezia (HP:0002573)1.86309536
95Recurrent sinusitis (HP:0011108)1.85790364
96Hypoproteinemia (HP:0003075)1.85161389
97Abnormality of DNA repair (HP:0003254)1.83602293
98Lymphoma (HP:0002665)1.83344125
99Abnormality of iron homeostasis (HP:0011031)1.83052044
100Pulmonary embolism (HP:0002204)1.82650983

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.90216585
2TAOK33.98538820
3MARK33.42661400
4TXK3.26839193
5EIF2AK32.40738035
6ZAP702.37710454
7IKBKE2.30054397
8MAP3K142.23447633
9BLK2.07722409
10TYK22.05291494
11GRK62.02966870
12RIPK41.99126062
13MAP3K131.98598488
14BTK1.97228667
15TBK11.88391876
16NME21.86273731
17SYK1.85807951
18PINK11.75147055
19IRAK41.74648805
20TNK21.69382335
21ITK1.67813062
22IKBKB1.67160823
23TEC1.59613259
24CSK1.54223474
25MAP3K51.54140520
26FGR1.48508082
27NLK1.42191541
28PRKCQ1.39252190
29FES1.28959664
30IRAK21.28902189
31KDR1.28536458
32CAMKK21.22403294
33SCYL21.19597611
34MAP2K31.19126593
35FRK1.18589895
36KIT1.15054921
37HCK1.06260878
38ADRBK21.04168639
39MAP3K11.02526343
40LCK1.01840851
41MAP3K110.98486379
42LYN0.98286223
43CSF1R0.97035951
44GRK50.91354866
45JAK10.90195420
46JAK30.85102524
47IRAK10.84419239
48BMPR20.84295108
49PDK10.81714198
50ACVR1B0.81067186
51MAP3K30.79305843
52BMPR1B0.77539614
53SIK30.77092079
54PIM10.76942241
55TLK10.76355507
56ADRBK10.70747066
57GRK70.69089122
58PRPF4B0.66876512
59MATK0.66691192
60LRRK20.66560675
61MYLK0.64480029
62PTK2B0.64419248
63MELK0.64225874
64OBSCN0.62129017
65EIF2AK10.60028139
66STK100.59888664
67JAK20.59597148
68TGFBR20.59497748
69MAPKAPK30.59412119
70MAP3K120.57641814
71GRK10.55295674
72CAMKK10.53825764
73PIK3CG0.50978495
74CLK10.47065561
75NEK60.47007327
76CSNK1G30.45840313
77BRSK20.45514522
78TAOK20.44703535
79TIE10.44359006
80PRKCH0.42533345
81NEK20.40458754
82PDK20.40056958
83MAPK110.39996767
84CSNK1A1L0.39057383
85STK38L0.37629804
86OXSR10.37422056
87PLK40.37295866
88EIF2AK20.36960312
89BCKDK0.35466105
90TGFBR10.32801692
91HIPK20.31581707
92PDPK10.30999281
93CHUK0.30276276
94MAPK150.28574184
95CDK30.26080630
96MAP2K60.25572093
97WEE10.25086218
98FGFR30.23212400
99CSNK1G10.22834243
100PRKG20.22050680

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.39590330
2Allograft rejection_Homo sapiens_hsa053303.78041919
3Graft-versus-host disease_Homo sapiens_hsa053323.54935807
4Autoimmune thyroid disease_Homo sapiens_hsa053203.47181495
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.90609408
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.75162799
7Antigen processing and presentation_Homo sapiens_hsa046122.65143196
8Asthma_Homo sapiens_hsa053102.57853186
9Type I diabetes mellitus_Homo sapiens_hsa049402.54971946
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.46675456
11Staphylococcus aureus infection_Homo sapiens_hsa051502.37114674
12Leishmaniasis_Homo sapiens_hsa051402.35209057
13Hematopoietic cell lineage_Homo sapiens_hsa046402.32385097
14T cell receptor signaling pathway_Homo sapiens_hsa046602.25547771
15Osteoclast differentiation_Homo sapiens_hsa043802.19018990
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.10621079
17Measles_Homo sapiens_hsa051621.91405005
18Herpes simplex infection_Homo sapiens_hsa051681.90613250
19B cell receptor signaling pathway_Homo sapiens_hsa046621.83627044
20Viral myocarditis_Homo sapiens_hsa054161.75388606
21Rheumatoid arthritis_Homo sapiens_hsa053231.73229538
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71901312
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64032824
24Legionellosis_Homo sapiens_hsa051341.62756232
25Malaria_Homo sapiens_hsa051441.62332593
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55694003
27Tuberculosis_Homo sapiens_hsa051521.55444750
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54587609
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50799906
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.47000330
31Proteasome_Homo sapiens_hsa030501.45243140
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37232587
33Influenza A_Homo sapiens_hsa051641.32236680
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23926678
35Toxoplasmosis_Homo sapiens_hsa051451.22026918
36TNF signaling pathway_Homo sapiens_hsa046681.17938748
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.17625187
38Epstein-Barr virus infection_Homo sapiens_hsa051691.01903345
39Pertussis_Homo sapiens_hsa051330.98149193
40Chemokine signaling pathway_Homo sapiens_hsa040620.93773584
41Phototransduction_Homo sapiens_hsa047440.89774432
42Apoptosis_Homo sapiens_hsa042100.89361586
43Phagosome_Homo sapiens_hsa041450.86873925
44Hepatitis B_Homo sapiens_hsa051610.85310015
45Olfactory transduction_Homo sapiens_hsa047400.82766103
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81577348
47African trypanosomiasis_Homo sapiens_hsa051430.77946450
48Ribosome_Homo sapiens_hsa030100.77915512
49Systemic lupus erythematosus_Homo sapiens_hsa053220.76049938
50Other glycan degradation_Homo sapiens_hsa005110.74701813
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73487660
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71602190
53Hepatitis C_Homo sapiens_hsa051600.64894440
54Regulation of autophagy_Homo sapiens_hsa041400.63483482
55Lysosome_Homo sapiens_hsa041420.63443919
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61921133
57Platelet activation_Homo sapiens_hsa046110.61769469
58Acute myeloid leukemia_Homo sapiens_hsa052210.60067999
59Viral carcinogenesis_Homo sapiens_hsa052030.55344966
60Chemical carcinogenesis_Homo sapiens_hsa052040.53100946
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51283481
62HTLV-I infection_Homo sapiens_hsa051660.50394967
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48596086
64Collecting duct acid secretion_Homo sapiens_hsa049660.48175376
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.47942614
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46588278
67Shigellosis_Homo sapiens_hsa051310.46156770
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40419358
69Arachidonic acid metabolism_Homo sapiens_hsa005900.40131548
70RNA degradation_Homo sapiens_hsa030180.40045103
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38024270
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37865026
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36097924
74Purine metabolism_Homo sapiens_hsa002300.34828189
75FoxO signaling pathway_Homo sapiens_hsa040680.34751474
76Homologous recombination_Homo sapiens_hsa034400.32390070
77Basal transcription factors_Homo sapiens_hsa030220.31498512
78Parkinsons disease_Homo sapiens_hsa050120.29954090
79Caffeine metabolism_Homo sapiens_hsa002320.29754191
80Nitrogen metabolism_Homo sapiens_hsa009100.28233707
81RNA polymerase_Homo sapiens_hsa030200.25983029
82One carbon pool by folate_Homo sapiens_hsa006700.25452710
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24779064
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.24175678
85Salmonella infection_Homo sapiens_hsa051320.24032928
86p53 signaling pathway_Homo sapiens_hsa041150.24030101
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22630678
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22390911
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22326618
90Pyrimidine metabolism_Homo sapiens_hsa002400.22096738
91Oxidative phosphorylation_Homo sapiens_hsa001900.21946557
92Glutathione metabolism_Homo sapiens_hsa004800.20187430
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.19237068
94MAPK signaling pathway_Homo sapiens_hsa040100.18909233
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18529399
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18195313
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14332391
98Tyrosine metabolism_Homo sapiens_hsa003500.12335894
99Mineral absorption_Homo sapiens_hsa049780.12066952
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.10464492

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »