RPL23AP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.55618670
2positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.74333556
3regulation of hypersensitivity (GO:0002883)5.24819672
4regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.18710795
5viral transcription (GO:0019083)5.12431337
6ribosomal small subunit biogenesis (GO:0042274)5.09010442
7translational termination (GO:0006415)4.99139592
8DNA deamination (GO:0045006)4.90716908
9pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.78120192
10positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.65294919
11positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.63204460
12maturation of SSU-rRNA (GO:0030490)4.62267826
13translational elongation (GO:0006414)4.44375850
14pyrimidine nucleotide catabolic process (GO:0006244)4.44164145
15positive regulation of mast cell degranulation (GO:0043306)4.37725789
16positive regulation of mast cell activation involved in immune response (GO:0033008)4.37725789
17positive regulation of interleukin-17 production (GO:0032740)4.35541177
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.29886983
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.28469840
20ATP synthesis coupled proton transport (GO:0015986)4.27562297
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27562297
22negative regulation of B cell apoptotic process (GO:0002903)4.24478683
23protein targeting to ER (GO:0045047)4.24253869
24cotranslational protein targeting to membrane (GO:0006613)4.23130826
25positive regulation of mast cell activation (GO:0033005)4.22062342
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.16700010
27base-excision repair, AP site formation (GO:0006285)4.08999366
28regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.07372635
29chaperone-mediated protein transport (GO:0072321)4.06640255
30establishment of protein localization to endoplasmic reticulum (GO:0072599)4.04063092
31regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.02925905
32protein localization to endoplasmic reticulum (GO:0070972)3.91096176
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.80187474
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.80187474
35viral life cycle (GO:0019058)3.72533537
36cellular protein complex disassembly (GO:0043624)3.68700746
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.64652032
38regulation of regulatory T cell differentiation (GO:0045589)3.61193457
39translational initiation (GO:0006413)3.59384767
40regulation of isotype switching to IgG isotypes (GO:0048302)3.54707799
41ribosomal large subunit biogenesis (GO:0042273)3.50875931
42ribonucleoprotein complex biogenesis (GO:0022613)3.50005192
43protein complex biogenesis (GO:0070271)3.45556468
44ubiquinone biosynthetic process (GO:0006744)3.41917911
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38572425
46kynurenine metabolic process (GO:0070189)3.35637821
47positive regulation of immunoglobulin mediated immune response (GO:0002891)3.35056958
48positive regulation of B cell mediated immunity (GO:0002714)3.35056958
49positive regulation of alpha-beta T cell proliferation (GO:0046641)3.32653359
50centriole replication (GO:0007099)3.32348369
51cellular component biogenesis (GO:0044085)3.29146059
52protein polyglutamylation (GO:0018095)3.27679697
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.26910533
54NADH dehydrogenase complex assembly (GO:0010257)3.26910533
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26910533
56translation (GO:0006412)3.26643578
57behavioral response to nicotine (GO:0035095)3.26381291
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.23140587
59maturation of 5.8S rRNA (GO:0000460)3.21909549
60respiratory chain complex IV assembly (GO:0008535)3.21745905
61mitochondrial respiratory chain complex assembly (GO:0033108)3.18360786
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16222396
63immunoglobulin mediated immune response (GO:0016064)3.13154102
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09320156
65negative regulation of mast cell activation (GO:0033004)3.08517544
66protein neddylation (GO:0045116)3.05161408
67spliceosomal complex assembly (GO:0000245)3.04320666
68respiratory electron transport chain (GO:0022904)3.03267833
69tryptophan catabolic process (GO:0006569)3.01149495
70indole-containing compound catabolic process (GO:0042436)3.01149495
71indolalkylamine catabolic process (GO:0046218)3.01149495
72deoxyribonucleotide catabolic process (GO:0009264)3.01085807
73ribosome biogenesis (GO:0042254)3.00377343
74protein complex disassembly (GO:0043241)2.99598847
75electron transport chain (GO:0022900)2.99015084
76positive regulation of isotype switching (GO:0045830)2.98418311
77regulation of immunoglobulin secretion (GO:0051023)2.95050378
78cytidine metabolic process (GO:0046087)2.93618132
79cytidine catabolic process (GO:0006216)2.93618132
80cytidine deamination (GO:0009972)2.93618132
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93593419
82cytochrome complex assembly (GO:0017004)2.92668880
83ubiquinone metabolic process (GO:0006743)2.92000385
84deoxyribose phosphate catabolic process (GO:0046386)2.90896334
85quinone biosynthetic process (GO:1901663)2.90781727
86nuclear-transcribed mRNA catabolic process (GO:0000956)2.90633254
87GTP biosynthetic process (GO:0006183)2.85400862
88RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.84748068
89protein-cofactor linkage (GO:0018065)2.82537046
90positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.81554764
91pyrimidine ribonucleoside catabolic process (GO:0046133)2.81507896
92macromolecular complex disassembly (GO:0032984)2.80220034
93chromatin remodeling at centromere (GO:0031055)2.77262350
94intra-S DNA damage checkpoint (GO:0031573)2.77065958
95mRNA catabolic process (GO:0006402)2.76810733
96positive regulation of activated T cell proliferation (GO:0042104)2.76646035
97rRNA processing (GO:0006364)2.74158767
98rRNA metabolic process (GO:0016072)2.73209222
99protein targeting to membrane (GO:0006612)2.69652256
100regulation of inflammatory response to antigenic stimulus (GO:0002861)2.67927447

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.46343606
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.90770689
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.72317821
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.41406591
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.30613888
6EZH2_22144423_ChIP-Seq_EOC_Human3.24090245
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05488506
8VDR_23849224_ChIP-Seq_CD4+_Human2.85662741
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.74482001
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.72433342
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60122887
12VDR_22108803_ChIP-Seq_LS180_Human2.56840642
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42267045
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.36152169
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.24086473
16ELK1_19687146_ChIP-ChIP_HELA_Human2.16325447
17ZNF274_21170338_ChIP-Seq_K562_Hela2.15913130
18FOXP3_21729870_ChIP-Seq_TREG_Human2.03442924
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99994783
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99955515
21IRF1_19129219_ChIP-ChIP_H3396_Human1.92794672
22IGF1R_20145208_ChIP-Seq_DFB_Human1.87953731
23EWS_26573619_Chip-Seq_HEK293_Human1.86464966
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81386722
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78687408
26MYC_18940864_ChIP-ChIP_HL60_Human1.77965100
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67606037
28TAF15_26573619_Chip-Seq_HEK293_Human1.65525519
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.59227832
30GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.59135655
31CIITA_25753668_ChIP-Seq_RAJI_Human1.53021478
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52071530
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49174640
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45862818
35FUS_26573619_Chip-Seq_HEK293_Human1.42373992
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39811834
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.37960362
38TTF2_22483619_ChIP-Seq_HELA_Human1.37297943
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31390098
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31340403
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30694344
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30496835
43GATA3_26560356_Chip-Seq_TH2_Human1.29947365
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29101956
45ER_23166858_ChIP-Seq_MCF-7_Human1.27138922
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26241527
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25234860
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24471698
49GABP_19822575_ChIP-Seq_HepG2_Human1.22523680
50STAT1_20625510_ChIP-Seq_HELA_Human1.22521435
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22309313
52P300_19829295_ChIP-Seq_ESCs_Human1.20927140
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20704464
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19490891
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18939251
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18116416
57NCOR_22424771_ChIP-Seq_293T_Human1.17636848
58NANOG_20526341_ChIP-Seq_ESCs_Human1.16662471
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15869958
60AR_20517297_ChIP-Seq_VCAP_Human1.14817512
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13383388
62ERA_21632823_ChIP-Seq_H3396_Human1.12660022
63TP53_22573176_ChIP-Seq_HFKS_Human1.12504578
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.10619727
65MYC_19829295_ChIP-Seq_ESCs_Human1.10204617
66HOXB7_26014856_ChIP-Seq_BT474_Human1.09808250
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.09371062
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08066555
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07875280
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07846210
71RBPJ_21746931_ChIP-Seq_IB4_Human1.06891460
72TAF2_19829295_ChIP-Seq_ESCs_Human1.06684468
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04676867
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03758888
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.03156532
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.02468978
77FOXH1_21741376_ChIP-Seq_EPCs_Human1.02366410
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02309425
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01224093
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01134134
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01129128
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00008775
83YY1_21170310_ChIP-Seq_MESCs_Mouse0.99311277
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99102332
85CBP_20019798_ChIP-Seq_JUKART_Human0.98968151
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98968151
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98962233
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98772290
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97831428
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97393839
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97343905
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.97343905
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.97123865
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95672007
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95594507
96ETV1_20927104_ChIP-Seq_GIST48_Human0.95383062
97BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94528788
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93534191
99ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93467366
100XRN2_22483619_ChIP-Seq_HELA_Human0.93407417

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.59653873
2MP0002138_abnormal_hepatobiliary_system4.15806636
3MP0001835_abnormal_antigen_presentation3.79352532
4MP0009379_abnormal_foot_pigmentation3.72937285
5MP0008877_abnormal_DNA_methylation3.49827247
6MP0005671_abnormal_response_to3.03689246
7MP0001853_heart_inflammation2.93851220
8MP0002163_abnormal_gland_morphology2.46840983
9MP0003786_premature_aging2.38604645
10MP0002837_dystrophic_cardiac_calcinosis2.33242628
11MP0004145_abnormal_muscle_electrophysio2.25870320
12MP0000465_gastrointestinal_hemorrhage2.02267719
13MP0000685_abnormal_immune_system1.97900291
14MP0000569_abnormal_digit_pigmentation1.86060708
15MP0005084_abnormal_gallbladder_morpholo1.75155576
16MP0002148_abnormal_hypersensitivity_rea1.68410546
17MP0006276_abnormal_autonomic_nervous1.67342575
18MP0001800_abnormal_humoral_immune1.63040326
19MP0008872_abnormal_physiological_respon1.59197556
20MP0001968_abnormal_touch/_nociception1.58740530
21MP0005387_immune_system_phenotype1.58723139
22MP0001790_abnormal_immune_system1.58723139
23MP0003646_muscle_fatigue1.49005418
24MP0008058_abnormal_DNA_repair1.46825814
25MP0003763_abnormal_thymus_physiology1.45437168
26MP0005645_abnormal_hypothalamus_physiol1.42585859
27MP0002653_abnormal_ependyma_morphology1.41935433
28MP0006036_abnormal_mitochondrial_physio1.41899587
29MP0008057_abnormal_DNA_replication1.39563136
30MP0004142_abnormal_muscle_tone1.39408772
31MP0001873_stomach_inflammation1.39359825
32MP0009785_altered_susceptibility_to1.34301000
33MP0003186_abnormal_redox_activity1.34250274
34MP0002234_abnormal_pharynx_morphology1.34023383
35MP0002876_abnormal_thyroid_physiology1.28673350
36MP0000604_amyloidosis1.28193830
37MP0005379_endocrine/exocrine_gland_phen1.24077923
38MP0002736_abnormal_nociception_after1.20527552
39MP0003787_abnormal_imprinting1.19878305
40MP0002139_abnormal_hepatobiliary_system1.18109685
41MP0002638_abnormal_pupillary_reflex1.16910954
42MP0002095_abnormal_skin_pigmentation1.16322904
43MP0005174_abnormal_tail_pigmentation1.14220997
44MP0005551_abnormal_eye_electrophysiolog1.14056958
45MP0002452_abnormal_antigen_presenting1.13360635
46MP0003880_abnormal_central_pattern1.07488589
47MP0002166_altered_tumor_susceptibility1.07437877
48MP0002006_tumorigenesis1.07144103
49MP0002723_abnormal_immune_serum1.06727375
50MP0005389_reproductive_system_phenotype1.04981018
51MP0002420_abnormal_adaptive_immunity1.04594795
52MP0008789_abnormal_olfactory_epithelium1.04477075
53MP0003718_maternal_effect1.03423224
54MP0006072_abnormal_retinal_apoptosis1.02650842
55MP0004147_increased_porphyrin_level1.02583247
56MP0004885_abnormal_endolymph1.00683418
57MP0001986_abnormal_taste_sensitivity1.00587630
58MP0004381_abnormal_hair_follicle0.99771375
59MP0001819_abnormal_immune_cell0.98586283
60MP0001905_abnormal_dopamine_level0.98566338
61MP0003195_calcinosis0.97421777
62MP0001293_anophthalmia0.96326311
63MP0005360_urolithiasis0.95937502
64MP0000049_abnormal_middle_ear0.95735544
65MP0002160_abnormal_reproductive_system0.94831808
66MP0002398_abnormal_bone_marrow0.88871179
67MP0000427_abnormal_hair_cycle0.88517381
68MP0003567_abnormal_fetal_cardiomyocyte0.87799793
69MP0003938_abnormal_ear_development0.87010604
70MP0002272_abnormal_nervous_system0.85767368
71MP0004742_abnormal_vestibular_system0.85478764
72MP0005410_abnormal_fertilization0.83711865
73MP0010094_abnormal_chromosome_stability0.83556201
74MP0000716_abnormal_immune_system0.81933099
75MP0002693_abnormal_pancreas_physiology0.81788170
76MP0005195_abnormal_posterior_eye0.81309223
77MP0005253_abnormal_eye_physiology0.78800675
78MP0008995_early_reproductive_senescence0.77633437
79MP0000230_abnormal_systemic_arterial0.77036965
80MP0003111_abnormal_nucleus_morphology0.75377872
81MP0003252_abnormal_bile_duct0.75257360
82MP0009764_decreased_sensitivity_to0.74905445
83MP0008775_abnormal_heart_ventricle0.73994639
84MP0002938_white_spotting0.73973786
85MP0003136_yellow_coat_color0.73915118
86MP0002405_respiratory_system_inflammati0.72930926
87MP0006035_abnormal_mitochondrial_morpho0.72715010
88MP0005636_abnormal_mineral_homeostasis0.72025375
89MP0005025_abnormal_response_to0.71038338
90MP0005000_abnormal_immune_tolerance0.70963949
91MP0008875_abnormal_xenobiotic_pharmacok0.70810481
92MP0005646_abnormal_pituitary_gland0.70251343
93MP0001765_abnormal_ion_homeostasis0.69590490
94MP0002733_abnormal_thermal_nociception0.69191953
95MP0000631_abnormal_neuroendocrine_gland0.67329432
96MP0002429_abnormal_blood_cell0.67306534
97MP0000703_abnormal_thymus_morphology0.65966413
98MP0001485_abnormal_pinna_reflex0.65231178
99MP0000678_abnormal_parathyroid_gland0.64635201
100MP0003011_delayed_dark_adaptation0.63941877

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)4.35580524
2Reticulocytopenia (HP:0001896)3.89625242
3Mitochondrial inheritance (HP:0001427)3.69642594
4Pancreatic cysts (HP:0001737)3.69270100
5Increased CSF lactate (HP:0002490)3.60474510
6Acute necrotizing encephalopathy (HP:0006965)3.54899983
7Acute encephalopathy (HP:0006846)3.43645958
8IgG deficiency (HP:0004315)3.41963502
9Increased hepatocellular lipid droplets (HP:0006565)3.40635500
10Pancreatic fibrosis (HP:0100732)3.34030363
11Stomatitis (HP:0010280)3.24247689
12Hyperalaninemia (HP:0003348)3.23488207
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.23488207
14Abnormality of alanine metabolism (HP:0010916)3.23488207
15Elevated erythrocyte sedimentation rate (HP:0003565)3.21554755
16Hepatocellular necrosis (HP:0001404)3.18819738
17Abnormality of midbrain morphology (HP:0002418)3.17935216
18Molar tooth sign on MRI (HP:0002419)3.17935216
19Progressive macrocephaly (HP:0004481)3.14237371
20Abnormal mitochondria in muscle tissue (HP:0008316)3.12576152
21Abnormality of DNA repair (HP:0003254)3.12446773
22Congenital stationary night blindness (HP:0007642)3.10761939
23Lipid accumulation in hepatocytes (HP:0006561)2.89271339
24Entropion (HP:0000621)2.83932743
25Renal Fanconi syndrome (HP:0001994)2.69844677
26Hepatic necrosis (HP:0002605)2.64326899
273-Methylglutaconic aciduria (HP:0003535)2.58334108
28Increased serum lactate (HP:0002151)2.58277002
29Colon cancer (HP:0003003)2.55679449
30Type II lissencephaly (HP:0007260)2.55456071
31Aplastic anemia (HP:0001915)2.55091115
32Macrocytic anemia (HP:0001972)2.54037186
33True hermaphroditism (HP:0010459)2.54027716
34Abnormality of cells of the erythroid lineage (HP:0012130)2.52997879
35Abnormality of secondary sexual hair (HP:0009888)2.50340207
36Abnormality of the axillary hair (HP:0100134)2.50340207
37Pancytopenia (HP:0001876)2.49493129
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37044666
39Cleft eyelid (HP:0000625)2.36508269
40Renal cortical cysts (HP:0000803)2.36006537
41Prostate neoplasm (HP:0100787)2.34430470
42Nephronophthisis (HP:0000090)2.33996884
43Sclerocornea (HP:0000647)2.30875222
44Abolished electroretinogram (ERG) (HP:0000550)2.29566647
45Hyperglycinemia (HP:0002154)2.23918091
46Severe muscular hypotonia (HP:0006829)2.23399769
47Hypoplasia of the radius (HP:0002984)2.23238604
48Hypoplasia of the pons (HP:0012110)2.23219485
49Abnormality of the prostate (HP:0008775)2.22672556
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22558172
51Absent thumb (HP:0009777)2.21738001
52Fair hair (HP:0002286)2.20022624
53Abnormal drinking behavior (HP:0030082)2.17720943
54Polydipsia (HP:0001959)2.17720943
55Lactic acidosis (HP:0003128)2.16968613
56Cerebral edema (HP:0002181)2.16625575
57Abnormality of the pons (HP:0007361)2.15110786
58Exertional dyspnea (HP:0002875)2.14164402
59Abnormality of the renal cortex (HP:0011035)2.09909701
60Abnormal rod and cone electroretinograms (HP:0008323)2.09682730
61Concave nail (HP:0001598)2.08757368
62Poikiloderma (HP:0001029)2.07713922
63Increased intramyocellular lipid droplets (HP:0012240)2.07200269
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06524691
65Postaxial foot polydactyly (HP:0001830)2.04240777
66Increased IgM level (HP:0003496)2.02958053
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01510218
68Pallor (HP:0000980)2.00832623
69Optic disc pallor (HP:0000543)1.99255408
70Type 2 muscle fiber atrophy (HP:0003554)1.98845328
71Chromsome breakage (HP:0040012)1.98568434
72Anencephaly (HP:0002323)1.98362164
73Abnormality of renal resorption (HP:0011038)1.96428648
74Abnormality of chromosome stability (HP:0003220)1.96027704
75Cystic liver disease (HP:0006706)1.94370536
76Abnormality of magnesium homeostasis (HP:0004921)1.91269043
77Chorioretinal atrophy (HP:0000533)1.90047545
78Abnormal respiratory motile cilium morphology (HP:0005938)1.89010383
79Abnormal respiratory epithelium morphology (HP:0012253)1.89010383
80Hypomagnesemia (HP:0002917)1.86358401
81Forearm undergrowth (HP:0009821)1.86298115
82Abnormality of serum amino acid levels (HP:0003112)1.85297944
83Leukodystrophy (HP:0002415)1.85149462
84Birth length less than 3rd percentile (HP:0003561)1.84490201
85Abnormal number of erythroid precursors (HP:0012131)1.82091349
86Stomach cancer (HP:0012126)1.81350149
87Porencephaly (HP:0002132)1.80252015
88Cerebellar dysplasia (HP:0007033)1.79747615
89Abnormality of the phalanges of the 5th finger (HP:0004213)1.79111275
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78661070
91Oligodactyly (hands) (HP:0001180)1.78143558
92Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.78051240
93Aplasia/Hypoplasia of the uvula (HP:0010293)1.75407317
94Hypoproteinemia (HP:0003075)1.73441043
95Lethargy (HP:0001254)1.72565672
96Male pseudohermaphroditism (HP:0000037)1.72346108
97Rib fusion (HP:0000902)1.71161542
98Triphalangeal thumb (HP:0001199)1.71047552
99Decreased circulating renin level (HP:0003351)1.70185507
100Alveolar cell carcinoma (HP:0006519)1.68544973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.73457407
2TXK3.77070382
3FRK3.35407949
4ZAK3.19517356
5STK162.71843479
6MUSK2.44672827
7EIF2AK12.44150891
8NEK12.11725978
9GRK12.00279668
10WNK41.94222396
11BUB11.86256618
12CDK191.84028828
13NUAK11.77016891
14MAP3K121.75912991
15PIK3CA1.73583259
16MAP4K11.68905277
17VRK11.63977705
18TEC1.61535467
19ADRBK21.59806582
20PINK11.46175495
21MKNK21.38161254
22OXSR11.37912549
23BTK1.35457207
24MKNK11.34340609
25BMPR1B1.29036921
26ITK1.27343062
27EIF2AK31.27097179
28IKBKB1.22350159
29PLK41.21672088
30DYRK21.20884217
31STK391.18928003
32GRK61.13024835
33BCKDK1.07762255
34TRIM281.07339531
35BMPR21.05420365
36CAMKK21.00267289
37NME10.98143397
38CDK80.94417270
39RPS6KA50.93359582
40WNK30.91768984
41MAP4K20.91483406
42SYK0.91048943
43FES0.88975872
44TIE10.86310591
45PRKD30.85932690
46PIK3CG0.85642868
47PIM10.82002214
48CAMK10.81285126
49CAMK1D0.80581173
50CSNK1G20.79866026
51ATR0.78844823
52NEK20.78665985
53PLK30.77623407
54HCK0.76725793
55MARK30.75924989
56ACVR1B0.74106994
57PLK10.73904532
58LRRK20.72705906
59CAMK1G0.71010858
60KDR0.69689709
61VRK20.69609111
62NLK0.69093897
63PNCK0.68482004
64PTK2B0.68366335
65LYN0.67347990
66AURKB0.63945651
67INSRR0.63357360
68MAP3K50.62653951
69CSK0.62469003
70OBSCN0.61028809
71MAP3K110.60535346
72RPS6KA40.59773559
73ADRBK10.57960673
74LCK0.57908892
75MAPKAPK50.56523441
76PDK20.55943302
77CSNK1G30.55342538
78PLK20.54498121
79CSNK2A20.53481597
80TRPM70.52922099
81EIF2AK20.51914033
82PRKCQ0.50616838
83TAOK30.49902815
84STK40.48966058
85CDC70.47276186
86CSNK2A10.47267854
87PRKCI0.46777002
88PHKG20.46541968
89PHKG10.46541968
90STK30.45754046
91CHEK20.45744661
92CSF1R0.45500060
93MELK0.44722835
94CSNK1A1L0.44162539
95AURKA0.40800951
96NME20.40755427
97CSNK1G10.37586469
98IGF1R0.35566423
99ABL10.34992596
100ATM0.34799645

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.40048979
2Ribosome_Homo sapiens_hsa030104.02476870
3Autoimmune thyroid disease_Homo sapiens_hsa053203.89799242
4Allograft rejection_Homo sapiens_hsa053303.88325554
5Graft-versus-host disease_Homo sapiens_hsa053323.65410588
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.51713065
7Type I diabetes mellitus_Homo sapiens_hsa049403.03654774
8Oxidative phosphorylation_Homo sapiens_hsa001902.77933482
9Parkinsons disease_Homo sapiens_hsa050122.28503587
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24528250
11Proteasome_Homo sapiens_hsa030502.18236281
12Homologous recombination_Homo sapiens_hsa034402.10355669
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80606259
14Viral myocarditis_Homo sapiens_hsa054161.78611168
15RNA polymerase_Homo sapiens_hsa030201.78037237
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73361119
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73123363
18Linoleic acid metabolism_Homo sapiens_hsa005911.71144622
19Nucleotide excision repair_Homo sapiens_hsa034201.61656882
20Huntingtons disease_Homo sapiens_hsa050161.59388121
21Basal transcription factors_Homo sapiens_hsa030221.55547410
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48504529
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46755187
24Primary immunodeficiency_Homo sapiens_hsa053401.46582392
25Antigen processing and presentation_Homo sapiens_hsa046121.46431677
26Rheumatoid arthritis_Homo sapiens_hsa053231.46173918
27RNA degradation_Homo sapiens_hsa030181.38130550
28Staphylococcus aureus infection_Homo sapiens_hsa051501.36733610
29Alzheimers disease_Homo sapiens_hsa050101.29488643
30One carbon pool by folate_Homo sapiens_hsa006701.27442454
31Protein export_Homo sapiens_hsa030601.21808935
32Phototransduction_Homo sapiens_hsa047441.19351651
33Mismatch repair_Homo sapiens_hsa034301.16757443
34Cardiac muscle contraction_Homo sapiens_hsa042601.16120957
35Hematopoietic cell lineage_Homo sapiens_hsa046401.14982327
36Base excision repair_Homo sapiens_hsa034101.14766473
37Fanconi anemia pathway_Homo sapiens_hsa034601.09689598
38Sulfur relay system_Homo sapiens_hsa041221.07363311
39DNA replication_Homo sapiens_hsa030301.06731813
40Systemic lupus erythematosus_Homo sapiens_hsa053220.99951136
41Pyrimidine metabolism_Homo sapiens_hsa002400.97721617
42Nitrogen metabolism_Homo sapiens_hsa009100.95399289
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91275070
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88309781
45RNA transport_Homo sapiens_hsa030130.87960153
46Ether lipid metabolism_Homo sapiens_hsa005650.86250804
47T cell receptor signaling pathway_Homo sapiens_hsa046600.72643385
48Purine metabolism_Homo sapiens_hsa002300.70349918
49Non-homologous end-joining_Homo sapiens_hsa034500.70006212
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69214840
51Leishmaniasis_Homo sapiens_hsa051400.68124196
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65800586
53Spliceosome_Homo sapiens_hsa030400.64157576
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62763374
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60387248
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58047497
57Olfactory transduction_Homo sapiens_hsa047400.56386490
58Fat digestion and absorption_Homo sapiens_hsa049750.55762270
59Arachidonic acid metabolism_Homo sapiens_hsa005900.55569249
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52720219
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52183273
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51378055
63Epstein-Barr virus infection_Homo sapiens_hsa051690.50336105
64Selenocompound metabolism_Homo sapiens_hsa004500.50197352
65Herpes simplex infection_Homo sapiens_hsa051680.48813377
66Sulfur metabolism_Homo sapiens_hsa009200.46714446
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.43717163
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43272719
69Butanoate metabolism_Homo sapiens_hsa006500.40228214
70Tryptophan metabolism_Homo sapiens_hsa003800.40199381
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38567448
72Chemical carcinogenesis_Homo sapiens_hsa052040.36294195
73Regulation of autophagy_Homo sapiens_hsa041400.35541920
74Folate biosynthesis_Homo sapiens_hsa007900.33081285
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32735365
76Metabolic pathways_Homo sapiens_hsa011000.32658203
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.31498566
78Malaria_Homo sapiens_hsa051440.30421833
79HTLV-I infection_Homo sapiens_hsa051660.29793272
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29643034
81Dorso-ventral axis formation_Homo sapiens_hsa043200.28029791
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.26902338
83Caffeine metabolism_Homo sapiens_hsa002320.26400536
84Tuberculosis_Homo sapiens_hsa051520.25581397
85Propanoate metabolism_Homo sapiens_hsa006400.24236816
86Influenza A_Homo sapiens_hsa051640.22992394
87Ovarian steroidogenesis_Homo sapiens_hsa049130.22689490
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.21759776
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20520478
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18540151
91Legionellosis_Homo sapiens_hsa051340.17963462
92Retinol metabolism_Homo sapiens_hsa008300.16968120
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16112221
94Fatty acid biosynthesis_Homo sapiens_hsa000610.15922263
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14094995
96Glycerolipid metabolism_Homo sapiens_hsa005610.13316821
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.12949515
98Vitamin digestion and absorption_Homo sapiens_hsa049770.12896939
99Toxoplasmosis_Homo sapiens_hsa051450.12801529
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11745833

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