ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	NADH metabolic process (GO:0006734)	8.00625008
2	ribosomal small subunit assembly (GO:0000028)	7.79907787
3	viral transcription (GO:0019083)	7.75826351
4	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	7.73834295
5	translational termination (GO:0006415)	7.34409033
6	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	7.18776961
7	translational elongation (GO:0006414)	6.60975778
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.12436132
9	cotranslational protein targeting to membrane (GO:0006613)	5.97895471
10	protein targeting to ER (GO:0045047)	5.94131332
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.84017113
12	viral life cycle (GO:0019058)	5.68599049
13	ribonucleoprotein complex biogenesis (GO:0022613)	5.65821193
14	cellular protein complex disassembly (GO:0043624)	5.65115725
15	ribosomal large subunit biogenesis (GO:0042273)	5.61639500
16	protein localization to endoplasmic reticulum (GO:0070972)	5.61362070
17	GMP metabolic process (GO:0046037)	5.40364497
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.22982945
19	regulation of sister chromatid cohesion (GO:0007063)	5.17558495
20	ATP synthesis coupled proton transport (GO:0015986)	4.88987785
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.88987785
22	respiratory electron transport chain (GO:0022904)	4.82088090
23	electron transport chain (GO:0022900)	4.79174872
24	translational initiation (GO:0006413)	4.75668332
25	cellular component biogenesis (GO:0044085)	4.72689830
26	protein complex disassembly (GO:0043241)	4.64314652
27	protein import into peroxisome matrix (GO:0016558)	4.63438185
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.51942808
29	macromolecular complex disassembly (GO:0032984)	4.28524029
30	oxygen transport (GO:0015671)	4.27078426
31	water-soluble vitamin biosynthetic process (GO:0042364)	4.25595601
32	maturation of SSU-rRNA (GO:0030490)	4.23372866
33	DNA deamination (GO:0045006)	4.23369982
34	NADH dehydrogenase complex assembly (GO:0010257)	4.19898689
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.19898689
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.19898689
37	chaperone-mediated protein transport (GO:0072321)	4.17177236
38	inositol phosphate dephosphorylation (GO:0046855)	4.00939932
39	phosphorylated carbohydrate dephosphorylation (GO:0046838)	4.00939932
40	protein targeting to membrane (GO:0006612)	3.92976598
41	translation (GO:0006412)	3.83331603
42	tricarboxylic acid metabolic process (GO:0072350)	3.73618073
43	purine-containing compound salvage (GO:0043101)	3.72231182
44	2-oxoglutarate metabolic process (GO:0006103)	3.69025358
45	gas transport (GO:0015669)	3.66513887
46	primary alcohol catabolic process (GO:0034310)	3.66236293
47	pyrimidine nucleoside salvage (GO:0043097)	3.62306487
48	pyrimidine-containing compound salvage (GO:0008655)	3.62306487
49	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.60035156
50	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	3.57999132
51	histone H4 deacetylation (GO:0070933)	3.55147481
52	negative regulation of Ras GTPase activity (GO:0034261)	3.54528707
53	regulation of cholesterol biosynthetic process (GO:0045540)	3.52335360
54	protein complex biogenesis (GO:0070271)	3.52256137
55	inositol phosphate catabolic process (GO:0071545)	3.52038754
56	nucleoside salvage (GO:0043174)	3.47606378
57	regulation of G0 to G1 transition (GO:0070316)	3.44746338
58	intracellular protein transmembrane import (GO:0044743)	3.44087496
59	rRNA processing (GO:0006364)	3.40207075
60	mRNA catabolic process (GO:0006402)	3.39960996
61	DNA synthesis involved in DNA repair (GO:0000731)	3.36049752
62	positive regulation of RNA splicing (GO:0033120)	3.32729238
63	regulation of interleukin-12 biosynthetic process (GO:0045075)	3.31595158
64	phosphatidylglycerol biosynthetic process (GO:0006655)	3.29201775
65	rRNA metabolic process (GO:0016072)	3.26155808
66	mitochondrial respiratory chain complex assembly (GO:0033108)	3.23732614
67	prostaglandin biosynthetic process (GO:0001516)	3.17261473
68	prostanoid biosynthetic process (GO:0046457)	3.17261473
69	positive regulation of Notch signaling pathway (GO:0045747)	3.08281917
70	ATP biosynthetic process (GO:0006754)	3.03303160
71	RNA catabolic process (GO:0006401)	2.96902400
72	regulation of energy homeostasis (GO:2000505)	2.91504246
73	protein targeting to peroxisome (GO:0006625)	2.89904098
74	establishment of protein localization to peroxisome (GO:0072663)	2.89904098
75	protein localization to peroxisome (GO:0072662)	2.89904098
76	mitochondrion distribution (GO:0048311)	2.85847937
77	protein targeting to mitochondrion (GO:0006626)	2.85316033
78	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.84552021
79	negative regulation of T-helper cell differentiation (GO:0045623)	2.84552021
80	protein targeting (GO:0006605)	2.84240035
81	establishment of protein localization to membrane (GO:0090150)	2.83872792
82	positive regulation of chemokine secretion (GO:0090197)	2.83422566
83	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.81847811
84	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.80397974
85	response to vitamin D (GO:0033280)	2.79632437
86	phenol-containing compound catabolic process (GO:0019336)	2.78865517
87	phosphatidylcholine biosynthetic process (GO:0006656)	2.77574588
88	histone H3 deacetylation (GO:0070932)	2.76789248
89	pseudouridine synthesis (GO:0001522)	2.76503979
90	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.74374045
91	cardiolipin metabolic process (GO:0032048)	2.72910863
92	ribosome biogenesis (GO:0042254)	2.70676562
93	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.69885617
94	preassembly of GPI anchor in ER membrane (GO:0016254)	2.67615873
95	hydrogen ion transmembrane transport (GO:1902600)	2.66026654
96	response to muscle activity (GO:0014850)	2.65694664
97	establishment of protein localization to organelle (GO:0072594)	2.63500445
98	response to redox state (GO:0051775)	2.61611031
99	ribosomal small subunit biogenesis (GO:0042274)	14.1846526
100	ncRNA 3-end processing (GO:0043628)	11.7635095

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	9.16946728
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.84720175
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.82958913
4	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.40768090
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.20513841
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.06851543
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.45843324
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.31516961
9	EGR1_19032775_ChIP-ChIP_M12_Human	2.28871576
10	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	2.17272270
11	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	2.16857739
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.16302069
13	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.15404708
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.12226481
15	XRN2_22483619_ChIP-Seq_HELA_Human	1.95986787
16	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.83603374
17	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.77360313
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.74509906
19	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.74478346
20	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.73384088
21	VDR_22108803_ChIP-Seq_LS180_Human	1.70007875
22	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.64510539
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.64239587
24	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.62790868
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.62140093
26	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.58613120
27	NANOG_20526341_ChIP-Seq_ESCs_Human	1.48626770
28	ZNF263_19887448_ChIP-Seq_K562_Human	1.47292877
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45716165
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42638726
31	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.42130562
32	KDM5A_27292631_Chip-Seq_BREAST_Human	1.38997626
33	BCL6_27268052_Chip-Seq_Bcells_Human	1.37344666
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35805779
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.35292161
36	EZH2_22144423_ChIP-Seq_EOC_Human	1.34702864
37	FUS_26573619_Chip-Seq_HEK293_Human	1.34167371
38	ERA_21632823_ChIP-Seq_H3396_Human	1.33928985
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.33580001
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.32149015
41	EWS_26573619_Chip-Seq_HEK293_Human	1.31574923
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.30852093
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.30223458
44	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.27752696
45	NCOR_22424771_ChIP-Seq_293T_Human	1.26132151
46	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.25877588
47	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.25663712
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.24342221
49	FOXP3_21729870_ChIP-Seq_TREG_Human	1.23130585
50	HTT_18923047_ChIP-ChIP_STHdh_Human	1.23108647
51	TAF2_19829295_ChIP-Seq_ESCs_Human	1.21956121
52	GABP_19822575_ChIP-Seq_HepG2_Human	1.21131022
53	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.20990407
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18849057
55	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17190814
56	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.16916540
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.16796471
58	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.14767326
59	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.13783901
60	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.13554482
61	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.13350295
62	CTCF_27219007_Chip-Seq_Bcells_Human	1.11513180
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09187982
64	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.08306216
65	SA1_27219007_Chip-Seq_Bcells_Human	1.07794774
66	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.05608410
67	PHF8_20622854_ChIP-Seq_HELA_Human	1.05591403
68	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.05113015
69	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04126942
70	ELK1_19687146_ChIP-ChIP_HELA_Human	1.03711511
71	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.03496137
72	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.02514874
73	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.02485329
74	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.02024498
75	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01545401
76	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.01531930
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.01175966
78	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.00834435
79	E2F1_20622854_ChIP-Seq_HELA_Human	1.00439331
80	BCOR_27268052_Chip-Seq_Bcells_Human	1.00133316
81	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.00106743
82	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.00074729
83	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.99280070
84	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.98883866
85	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.98618729
86	RBPJ_21746931_ChIP-Seq_IB4_Human	0.97700117
87	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.97544073
88	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.96491980
89	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.95006733
90	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.94886513
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94436824
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94351541
93	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.93184334
94	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.92423391
95	P300_27268052_Chip-Seq_Bcells_Human	0.92242748
96	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.91949312
97	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.91831862
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.91193900
99	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90277796
100	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.90216425

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004510_myositis	7.94892723
2	MP0003879_abnormal_hair_cell	5.62821819
3	MP0001873_stomach_inflammation	4.77179147
4	MP0006082_CNS_inflammation	4.57450488
5	MP0001727_abnormal_embryo_implantation	3.77272654
6	MP0003121_genomic_imprinting	3.08015862
7	MP0000015_abnormal_ear_pigmentation	2.85369019
8	MP0002163_abnormal_gland_morphology	2.84670265
9	MP0006292_abnormal_olfactory_placode	2.83814677
10	MP0009780_abnormal_chondrocyte_physiolo	2.22551095
11	MP0005646_abnormal_pituitary_gland	2.13708518
12	MP0005075_abnormal_melanosome_morpholog	2.11890970
13	MP0003693_abnormal_embryo_hatching	2.04005416
14	MP0003195_calcinosis	2.02889471
15	MP0002933_joint_inflammation	1.95526779
16	MP0003878_abnormal_ear_physiology	1.88362542
17	MP0005377_hearing/vestibular/ear_phenot	1.88362542
18	MP0004885_abnormal_endolymph	1.87452443
19	MP0009379_abnormal_foot_pigmentation	1.75066138
20	MP0002095_abnormal_skin_pigmentation	1.63764874
21	MP0008875_abnormal_xenobiotic_pharmacok	1.63232743
22	MP0005174_abnormal_tail_pigmentation	1.56461211
23	MP0002138_abnormal_hepatobiliary_system	1.55200288
24	MP0005379_endocrine/exocrine_gland_phen	1.55037883
25	MP0001663_abnormal_digestive_system	1.53096210
26	MP0002132_abnormal_respiratory_system	1.51717030
27	MP0004858_abnormal_nervous_system	1.42921542
28	MP0002876_abnormal_thyroid_physiology	1.42476842
29	MP0001851_eye_inflammation	1.38818349
30	MP0006276_abnormal_autonomic_nervous	1.38798207
31	MP0009333_abnormal_splenocyte_physiolog	1.35688240
32	MP0001905_abnormal_dopamine_level	1.34830695
33	MP0004742_abnormal_vestibular_system	1.33838387
34	MP0003136_yellow_coat_color	1.31301433
35	MP0002277_abnormal_respiratory_mucosa	1.22418684
36	MP0005381_digestive/alimentary_phenotyp	1.16216341
37	MP0004145_abnormal_muscle_electrophysio	1.13692419
38	MP0009785_altered_susceptibility_to	1.12582063
39	MP0002736_abnormal_nociception_after	1.09965994
40	MP0004142_abnormal_muscle_tone	1.09845100
41	MP0004147_increased_porphyrin_level	1.04463659
42	MP0001968_abnormal_touch/_nociception	1.01907650
43	MP0008872_abnormal_physiological_respon	0.97938072
44	MP0009765_abnormal_xenobiotic_induced	0.95856254
45	MP0002837_dystrophic_cardiac_calcinosis	0.94761326
46	MP0002638_abnormal_pupillary_reflex	0.93561580
47	MP0000026_abnormal_inner_ear	0.92413341
48	MP0005671_abnormal_response_to	0.91739883
49	MP0001188_hyperpigmentation	0.89872359
50	MP0000631_abnormal_neuroendocrine_gland	0.84772370
51	MP0005636_abnormal_mineral_homeostasis	0.84554540
52	MP0001986_abnormal_taste_sensitivity	0.81096945
53	MP0001963_abnormal_hearing_physiology	0.78009757
54	MP0005551_abnormal_eye_electrophysiolog	0.77555015
55	MP0000566_synostosis	0.77045858
56	MP0000371_diluted_coat_color	0.76743598
57	MP0000703_abnormal_thymus_morphology	0.75702283
58	MP0002405_respiratory_system_inflammati	0.75157345
59	MP0001881_abnormal_mammary_gland	0.74548144
60	MP0004133_heterotaxia	0.71740655
61	MP0004381_abnormal_hair_follicle	0.71494085
62	MP0001800_abnormal_humoral_immune	0.70722953
63	MP0002229_neurodegeneration	0.70334009
64	MP0001919_abnormal_reproductive_system	0.70126905
65	MP0006036_abnormal_mitochondrial_physio	0.70087850
66	MP0002272_abnormal_nervous_system	0.69586554
67	MP0003880_abnormal_central_pattern	0.67395589
68	MP0009745_abnormal_behavioral_response	0.66911564
69	MP0002160_abnormal_reproductive_system	0.66456722
70	MP0003646_muscle_fatigue	0.66355362
71	MP0003938_abnormal_ear_development	0.65920041
72	MP0008877_abnormal_DNA_methylation	0.65083148
73	MP0003186_abnormal_redox_activity	0.64981887
74	MP0002752_abnormal_somatic_nervous	0.64698106
75	MP0002116_abnormal_craniofacial_bone	0.61576901
76	MP0003718_maternal_effect	0.58837312
77	MP0005220_abnormal_exocrine_pancreas	0.58752054
78	MP0009046_muscle_twitch	0.58706394
79	MP0002210_abnormal_sex_determination	0.58415216
80	MP0005389_reproductive_system_phenotype	0.58212402
81	MP0008995_early_reproductive_senescence	0.56738571
82	MP0008058_abnormal_DNA_repair	0.56062620
83	MP0005397_hematopoietic_system_phenotyp	0.55999191
84	MP0001545_abnormal_hematopoietic_system	0.55999191
85	MP0002234_abnormal_pharynx_morphology	0.54812007
86	MP0000049_abnormal_middle_ear	0.54583633
87	MP0000678_abnormal_parathyroid_gland	0.54098588
88	MP0003123_paternal_imprinting	0.53900804
89	MP0002653_abnormal_ependyma_morphology	0.52580253
90	MP0003011_delayed_dark_adaptation	0.52539666
91	MP0000689_abnormal_spleen_morphology	0.52183017
92	MP0001533_abnormal_skeleton_physiology	0.52110342
93	MP0001915_intracranial_hemorrhage	0.51994535
94	MP0004947_skin_inflammation	0.51937845
95	MP0001764_abnormal_homeostasis	0.51803127
96	MP0001324_abnormal_eye_pigmentation	0.51446750
97	MP0005195_abnormal_posterior_eye	0.51049840
98	MP0003866_abnormal_defecation	0.48371219
99	MP0003941_abnormal_skin_development	0.47051643
100	MP0004043_abnormal_pH_regulation	0.46176639

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of macular pigmentation (HP:0008002)	7.91236862
2	Metaphyseal cupping (HP:0003021)	7.47080526
3	Striae distensae (HP:0001065)	6.96386603
4	Constricted visual fields (HP:0001133)	6.86225055
5	Round ear (HP:0100830)	6.69656241
6	Volvulus (HP:0002580)	6.17089711
7	Cupped ribs (HP:0000887)	5.75968556
8	Cone-rod dystrophy (HP:0000548)	5.71733739
9	Toxemia of pregnancy (HP:0100603)	5.24379734
10	Attenuation of retinal blood vessels (HP:0007843)	4.95024981
11	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.83358172
12	Acute necrotizing encephalopathy (HP:0006965)	4.58526032
13	Abnormal mitochondria in muscle tissue (HP:0008316)	4.21414683
14	Acute encephalopathy (HP:0006846)	3.89848641
15	Large earlobe (HP:0009748)	3.84863474
16	Progressive macrocephaly (HP:0004481)	3.79239091
17	Optic disc pallor (HP:0000543)	3.77576337
18	Oligodontia (HP:0000677)	3.46771094
19	Abnormal hemoglobin (HP:0011902)	3.39556234
20	Tibial bowing (HP:0002982)	3.25458311
21	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.16090863
22	Broad nasal tip (HP:0000455)	3.15720226
23	Hyperthyroidism (HP:0000836)	3.13956553
24	Decreased muscle mass (HP:0003199)	3.12981919
25	Cerebral edema (HP:0002181)	3.12270738
26	Mitochondrial inheritance (HP:0001427)	3.11008500
27	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.08522621
28	Albinism (HP:0001022)	3.00768588
29	Concave nail (HP:0001598)	3.00767535
30	Lack of skin elasticity (HP:0100679)	3.00373095
31	Brushfield spots (HP:0001088)	2.95126236
32	Small hand (HP:0200055)	2.93837939
33	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.92959001
34	Abnormality of cells of the erythroid lineage (HP:0012130)	2.85179285
35	Femoral bowing (HP:0002980)	2.77861658
36	Prominent supraorbital ridges (HP:0000336)	2.75638416
37	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.74670976
38	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.74670976
39	Abnormal number of erythroid precursors (HP:0012131)	2.74062050
40	Pallor (HP:0000980)	2.73239043
41	Increased CSF lactate (HP:0002490)	2.72825553
42	Severe visual impairment (HP:0001141)	2.69754180
43	Ovoid vertebral bodies (HP:0003300)	2.60161426
44	Hyperglycinemia (HP:0002154)	2.57496287
45	Macrocytic anemia (HP:0001972)	2.55886273
46	Abnormality of the labia minora (HP:0012880)	2.54325798
47	Coxa vara (HP:0002812)	2.46140440
48	Hepatocellular necrosis (HP:0001404)	2.24464641
49	Reticulocytopenia (HP:0001896)	2.21922025
50	Postnatal growth retardation (HP:0008897)	2.16294766
51	Recurrent otitis media (HP:0000403)	2.08341607
52	Limited elbow extension (HP:0001377)	2.00507104
53	Emotional lability (HP:0000712)	2.00123106
54	Hepatic necrosis (HP:0002605)	1.98000284
55	Molar tooth sign on MRI (HP:0002419)	1.97566647
56	Abnormality of midbrain morphology (HP:0002418)	1.97566647
57	Abnormality of lateral ventricle (HP:0030047)	1.95137888
58	Abnormality of the anterior horn cell (HP:0006802)	1.94668534
59	Degeneration of anterior horn cells (HP:0002398)	1.94668534
60	Proximal placement of thumb (HP:0009623)	1.94362718
61	Prenatal maternal abnormality (HP:0002686)	1.94135009
62	Hypoplastic ilia (HP:0000946)	1.92441339
63	Lactic acidosis (HP:0003128)	1.92379224
64	Truncus arteriosus (HP:0001660)	1.91054629
65	3-Methylglutaconic aciduria (HP:0003535)	1.90956295
66	Congenital stationary night blindness (HP:0007642)	1.90148351
67	Progressive visual loss (HP:0000529)	1.88906125
68	Increased intramyocellular lipid droplets (HP:0012240)	1.87757137
69	Epiphyseal stippling (HP:0010655)	1.85003643
70	Absent/shortened dynein arms (HP:0200106)	1.83729573
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.83729573
72	X-linked dominant inheritance (HP:0001423)	1.83466779
73	Methylmalonic acidemia (HP:0002912)	1.79184514
74	Respiratory failure (HP:0002878)	1.73762565
75	Childhood onset (HP:0011463)	1.72221761
76	Congenital, generalized hypertrichosis (HP:0004540)	1.71153430
77	Blepharitis (HP:0000498)	1.70525983
78	Delayed puberty (HP:0000823)	1.69998818
79	Renal Fanconi syndrome (HP:0001994)	1.69223423
80	Rhizomelia (HP:0008905)	1.68429785
81	Leukodystrophy (HP:0002415)	1.68236684
82	Lethargy (HP:0001254)	1.66080815
83	Increased nuchal translucency (HP:0010880)	1.63070974
84	Hypomagnesemia (HP:0002917)	1.62809011
85	Abnormality of magnesium homeostasis (HP:0004921)	1.60416077
86	Exercise intolerance (HP:0003546)	1.59389792
87	Gout (HP:0001997)	1.56282857
88	Deviation of the thumb (HP:0009603)	1.55589012
89	Freckling (HP:0001480)	1.54341503
90	Tetany (HP:0001281)	1.53973763
91	Akinesia (HP:0002304)	1.53000522
92	Retinitis pigmentosa (HP:0000510)	1.52833164
93	Female pseudohermaphroditism (HP:0010458)	1.52678480
94	Increased hepatocellular lipid droplets (HP:0006565)	1.52414179
95	Multicystic kidney dysplasia (HP:0000003)	1.49637660
96	Increased muscle lipid content (HP:0009058)	1.49312758
97	Nasal polyposis (HP:0100582)	1.49104755
98	Abnormality of fatty-acid metabolism (HP:0004359)	1.47484233
99	Hyperalaninemia (HP:0003348)	1.45080807
100	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.45080807

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	KIT	8.26961874
2	FES	4.82676715
3	TEC	3.88274108
4	BCKDK	3.28539809
5	NME2	2.97968949
6	SIK2	2.62664181
7	IKBKB	2.57849199
8	WNK4	2.39579120
9	MAP4K1	2.17547954
10	TYRO3	2.14021012
11	CDK19	2.03719626
12	ABL2	1.98333590
13	SYK	1.80009080
14	STK16	1.67794070
15	ADRBK2	1.58634110
16	TLK1	1.53455679
17	GRK1	1.46549142
18	RET	1.41742105
19	TESK2	1.32138136
20	TXK	1.25794250
21	CSK	1.25328665
22	ZAK	1.19042570
23	PDK2	1.17128213
24	RPS6KA5	1.16653618
25	LMTK2	1.13725068
26	CDK3	1.10378890
27	CDC7	1.10349586
28	BUB1	1.06204170
29	ADRBK1	1.05240129
30	DYRK2	1.04769889
31	IKBKE	1.03925067
32	NME1	1.03465500
33	LRRK2	1.01879486
34	RPS6KA4	0.99426954
35	PINK1	0.95924582
36	MAP4K2	0.90704943
37	CSF1R	0.90483634
38	RPS6KB2	0.86181288
39	INSRR	0.83404979
40	PRKACA	0.73681854
41	PRKCG	0.73488765
42	PRKCQ	0.72836440
43	INSR	0.69635397
44	CHEK2	0.66328288
45	BTK	0.65847175
46	OBSCN	0.65119011
47	OXSR1	0.63715419
48	STK39	0.61821592
49	DYRK3	0.61194016
50	TIE1	0.60029583
51	EIF2AK1	0.56443451
52	CSNK1D	0.55142827
53	EGFR	0.55000724
54	AURKA	0.54509320
55	JAK3	0.52903939
56	CAMK2A	0.51528998
57	LCK	0.51359638
58	MAPK10	0.51265540
59	PRKACG	0.50331466
60	CSNK2A1	0.49717719
61	PDPK1	0.49561486
62	SRC	0.48996170
63	NEK2	0.46519437
64	FGR	0.46353788
65	LYN	0.46337254
66	ABL1	0.45632216
67	PIM2	0.45455294
68	PDK1	0.45363117
69	PRKCA	0.45107164
70	WNK3	0.44647061
71	ARAF	0.43474982
72	PASK	0.43257562
73	CSNK2A2	0.43056353
74	CSNK1A1	0.43035133
75	PKN1	0.42455018
76	CAMK2B	0.41491673
77	PRKG2	0.41139749
78	CSNK1E	0.39766015
79	PRKCB	0.39294750
80	ILK	0.38701661
81	TRPM7	0.38137141
82	PHKG2	0.36419959
83	PHKG1	0.36419959
84	MUSK	0.35736797
85	WNK1	0.34694339
86	PIM1	0.34501015
87	PRKCD	0.33733533
88	ATM	0.33439204
89	RPS6KA6	0.33387051
90	MAPKAPK5	0.33358912
91	AURKB	0.32511966
92	CAMK2D	0.32454157
93	RPS6KA1	0.30212458
94	PRKACB	0.30101000
95	PRKCH	0.26394070
96	TBK1	0.25811826
97	PLK1	0.25605608
98	PLK4	0.25357627
99	RPS6KC1	0.25201115
100	RPS6KL1	0.25201115

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.58044359
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.29006316
3	Parkinsons disease_Homo sapiens_hsa05012	4.28555750
4	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	3.54261962
5	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.96238610
6	Huntingtons disease_Homo sapiens_hsa05016	2.89557590
7	Alzheimers disease_Homo sapiens_hsa05010	2.85079423
8	Phototransduction_Homo sapiens_hsa04744	2.20608685
9	Proteasome_Homo sapiens_hsa03050	2.04218861
10	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.90269698
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.79615230
12	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.77322108
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.68880599
14	Sulfur metabolism_Homo sapiens_hsa00920	1.68205029
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.61148750
16	One carbon pool by folate_Homo sapiens_hsa00670	1.57775013
17	Mismatch repair_Homo sapiens_hsa03430	1.56076237
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.39251910
19	RNA polymerase_Homo sapiens_hsa03020	1.35852377
20	Nicotine addiction_Homo sapiens_hsa05033	1.27304278
21	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.26920445
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19740518
23	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.16913322
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.16614454
25	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.15365295
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14812649
27	Histidine metabolism_Homo sapiens_hsa00340	1.10620431
28	Caffeine metabolism_Homo sapiens_hsa00232	1.07998236
29	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.07635702
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.05325102
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.02633360
32	Alcoholism_Homo sapiens_hsa05034	0.98115504
33	Pyruvate metabolism_Homo sapiens_hsa00620	0.97154360
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96197314
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.94929031
36	Asthma_Homo sapiens_hsa05310	0.94827259
37	Tyrosine metabolism_Homo sapiens_hsa00350	0.90423680
38	Purine metabolism_Homo sapiens_hsa00230	0.90240060
39	Homologous recombination_Homo sapiens_hsa03440	0.90019322
40	DNA replication_Homo sapiens_hsa03030	0.89993587
41	Olfactory transduction_Homo sapiens_hsa04740	0.89796650
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88757925
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87512592
44	beta-Alanine metabolism_Homo sapiens_hsa00410	0.87288216
45	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.83773767
46	Protein export_Homo sapiens_hsa03060	0.83022509
47	Metabolic pathways_Homo sapiens_hsa01100	0.81057573
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.80558425
49	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.76900461
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75115968
51	Peroxisome_Homo sapiens_hsa04146	0.70464565
52	Basal transcription factors_Homo sapiens_hsa03022	0.69519989
53	Sulfur relay system_Homo sapiens_hsa04122	0.67158875
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.66510462
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.66346897
56	Folate biosynthesis_Homo sapiens_hsa00790	0.65355296
57	Graft-versus-host disease_Homo sapiens_hsa05332	0.63995265
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.63627527
59	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.63150486
60	Allograft rejection_Homo sapiens_hsa05330	0.62293869
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61820684
62	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.60201677
63	Nucleotide excision repair_Homo sapiens_hsa03420	0.57602540
64	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.56927974
65	Base excision repair_Homo sapiens_hsa03410	0.55782838
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53993388
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.52261818
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52210285
69	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.50548707
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.49886286
71	RNA degradation_Homo sapiens_hsa03018	0.48443077
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47476776
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45770581
74	Malaria_Homo sapiens_hsa05144	0.44824891
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.44713725
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43695597
77	Fanconi anemia pathway_Homo sapiens_hsa03460	0.43648850
78	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.42508717
79	Retinol metabolism_Homo sapiens_hsa00830	0.41813664
80	Morphine addiction_Homo sapiens_hsa05032	0.41488908
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41283714
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.39839078
83	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.38765969
84	Type I diabetes mellitus_Homo sapiens_hsa04940	0.35982285
85	Serotonergic synapse_Homo sapiens_hsa04726	0.34596573
86	Taste transduction_Homo sapiens_hsa04742	0.34571276
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33856370
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.32990592
89	Phenylalanine metabolism_Homo sapiens_hsa00360	0.31987673
90	Rheumatoid arthritis_Homo sapiens_hsa05323	0.31384830
91	Spliceosome_Homo sapiens_hsa03040	0.30097422
92	Melanoma_Homo sapiens_hsa05218	0.29192438
93	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.29053315
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28120035
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.26957711
96	Carbon metabolism_Homo sapiens_hsa01200	0.26127623
97	FoxO signaling pathway_Homo sapiens_hsa04068	0.25957320
98	Fatty acid degradation_Homo sapiens_hsa00071	0.25956488
99	Bladder cancer_Homo sapiens_hsa05219	0.24513740
100	GABAergic synapse_Homo sapiens_hsa04727	0.22611580

RPL23AP12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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