ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.08931392
2	opioid receptor signaling pathway (GO:0038003)	5.30762934
3	ribosomal small subunit assembly (GO:0000028)	5.27012753
4	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.93380152
5	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	4.90305689
6	isotype switching (GO:0045190)	4.90305689
7	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	4.90305689
8	ribosomal small subunit biogenesis (GO:0042274)	4.76053899
9	viral transcription (GO:0019083)	4.70348495
10	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.62274916
11	translational termination (GO:0006415)	4.54207785
12	maturation of 5.8S rRNA (GO:0000460)	4.38617334
13	maturation of SSU-rRNA (GO:0030490)	4.27490296
14	water-soluble vitamin biosynthetic process (GO:0042364)	4.27405188
15	translational elongation (GO:0006414)	4.23730806
16	behavioral response to ethanol (GO:0048149)	4.17109694
17	ether lipid metabolic process (GO:0046485)	3.98887277
18	piRNA metabolic process (GO:0034587)	3.89762939
19	behavioral response to nicotine (GO:0035095)	3.88575829
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.88498237
21	ribosomal large subunit biogenesis (GO:0042273)	3.85673978
22	negative regulation of cAMP-mediated signaling (GO:0043951)	3.85395235
23	respiratory chain complex IV assembly (GO:0008535)	3.85062730
24	preassembly of GPI anchor in ER membrane (GO:0016254)	3.81552530
25	cotranslational protein targeting to membrane (GO:0006613)	3.81256930
26	somatic diversification of immunoglobulins (GO:0016445)	3.77711345
27	protein targeting to ER (GO:0045047)	3.76864400
28	platelet dense granule organization (GO:0060155)	3.76610749
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.69371941
30	NADH dehydrogenase complex assembly (GO:0010257)	3.69371941
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.69371941
32	somatic recombination of immunoglobulin gene segments (GO:0016447)	3.68808141
33	protein complex biogenesis (GO:0070271)	3.68218668
34	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.63628795
35	ATP synthesis coupled proton transport (GO:0015986)	3.63628795
36	protein localization to endoplasmic reticulum (GO:0070972)	3.59310483
37	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.58993887
38	rRNA modification (GO:0000154)	3.58678278
39	regulation of translational termination (GO:0006449)	3.57856454
40	regulation of mitotic spindle checkpoint (GO:1903504)	3.54789748
41	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.54789748
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.52720929
43	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.48497646
44	rRNA methylation (GO:0031167)	3.47872958
45	chaperone-mediated protein transport (GO:0072321)	3.45360355
46	anterograde synaptic vesicle transport (GO:0048490)	3.45095377
47	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.38494651
48	rRNA processing (GO:0006364)	3.36747277
49	rRNA metabolic process (GO:0016072)	3.32752837
50	proteasome assembly (GO:0043248)	3.31098253
51	cytochrome complex assembly (GO:0017004)	3.29034595
52	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.28649398
53	cellular protein complex disassembly (GO:0043624)	3.27708188
54	viral life cycle (GO:0019058)	3.27017968
55	detection of light stimulus involved in visual perception (GO:0050908)	3.26016256
56	detection of light stimulus involved in sensory perception (GO:0050962)	3.26016256
57	GTP biosynthetic process (GO:0006183)	3.24998662
58	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.15856258
59	electron transport chain (GO:0022900)	3.13382138
60	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.12504023
61	regulation of cilium movement (GO:0003352)	3.10042637
62	respiratory electron transport chain (GO:0022904)	3.08932178
63	translation (GO:0006412)	3.04890332
64	aldehyde catabolic process (GO:0046185)	3.04480286
65	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.00942097
66	termination of RNA polymerase III transcription (GO:0006386)	3.00942097
67	axoneme assembly (GO:0035082)	2.99755809
68	pattern specification involved in kidney development (GO:0061004)	2.97425287
69	ncRNA catabolic process (GO:0034661)	2.95302546
70	response to misfolded protein (GO:0051788)	2.94102943
71	CTP metabolic process (GO:0046036)	2.91775220
72	CTP biosynthetic process (GO:0006241)	2.91775220
73	translational initiation (GO:0006413)	2.89866010
74	cellular component biogenesis (GO:0044085)	2.89124061
75	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.88498586
76	tryptophan metabolic process (GO:0006568)	2.88220442
77	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.86520154
78	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.81922395
79	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.78549735
80	spliceosomal complex assembly (GO:0000245)	2.78197624
81	indolalkylamine metabolic process (GO:0006586)	2.78113112
82	ketone body metabolic process (GO:1902224)	2.77925413
83	GPI anchor metabolic process (GO:0006505)	2.75427044
84	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.74829193
85	ribonucleoprotein complex biogenesis (GO:0022613)	2.73117223
86	B cell activation involved in immune response (GO:0002312)	2.71615859
87	retinal rod cell development (GO:0046548)	2.71123054
88	mRNA catabolic process (GO:0006402)	2.67330153
89	multicellular organism reproduction (GO:0032504)	2.66767478
90	signal peptide processing (GO:0006465)	2.61604850
91	GPI anchor biosynthetic process (GO:0006506)	2.60815523
92	protein complex disassembly (GO:0043241)	2.60448193
93	UTP biosynthetic process (GO:0006228)	2.59924083
94	macromolecular complex disassembly (GO:0032984)	2.59334597
95	protein localization to cilium (GO:0061512)	2.59151592
96	ATP biosynthetic process (GO:0006754)	2.58986203
97	anterograde axon cargo transport (GO:0008089)	2.57463312
98	rRNA catabolic process (GO:0016075)	2.57442370
99	somatic diversification of immune receptors (GO:0002200)	2.56398079
100	RNA phosphodiester bond hydrolysis (GO:0090501)	2.56273904

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.09121133
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.03321915
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.78503799
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.21025466
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.06529551
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.88071259
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.84082442
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.76381905
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.75055926
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.65066535
11	VDR_22108803_ChIP-Seq_LS180_Human	2.41905687
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.39843828
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.33286289
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.28171468
15	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.05636059
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.01109325
17	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.90673562
18	TP53_22573176_ChIP-Seq_HFKS_Human	1.85437871
19	EWS_26573619_Chip-Seq_HEK293_Human	1.84234476
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.83810148
21	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.83564615
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.75379963
23	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.73515962
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.65855713
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62402640
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.57012697
27	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.50713271
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49971050
29	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.48668389
30	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.44796420
31	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.44297161
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42376675
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42376675
34	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.41353450
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.40585908
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.40057919
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39549401
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39549401
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.37725929
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37725929
41	NANOG_20526341_ChIP-Seq_ESCs_Human	1.35341373
42	MYC_19829295_ChIP-Seq_ESCs_Human	1.35093196
43	TAF2_19829295_ChIP-Seq_ESCs_Human	1.32966836
44	RUNX_20019798_ChIP-Seq_JUKART_Human	1.32546893
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26726791
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26649617
47	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26649617
48	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.26532122
49	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.26438913
50	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.26346134
51	NCOR_22424771_ChIP-Seq_293T_Human	1.26199952
52	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21977107
53	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.21660054
54	CTCF_20526341_ChIP-Seq_ESCs_Human	1.21000153
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20764987
56	P53_21459846_ChIP-Seq_SAOS-2_Human	1.20734915
57	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.19089395
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16153176
59	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15818631
60	P300_19829295_ChIP-Seq_ESCs_Human	1.13418950
61	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.13294552
62	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13132119
63	TTF2_22483619_ChIP-Seq_HELA_Human	1.13019969
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12669189
65	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12630513
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12303501
67	GABP_19822575_ChIP-Seq_HepG2_Human	1.12176596
68	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11948760
69	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.09772533
70	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08357806
71	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.06216381
72	FUS_26573619_Chip-Seq_HEK293_Human	1.05291296
73	ERA_21632823_ChIP-Seq_H3396_Human	1.04262031
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03591061
75	SMRT_27268052_Chip-Seq_Bcells_Human	1.01903778
76	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.00786495
77	STAT1_20625510_ChIP-Seq_HELA_Human	1.00656810
78	E2F1_20622854_ChIP-Seq_HELA_Human	1.00413863
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.00296028
80	ERG_20517297_ChIP-Seq_VCAP_Human	0.99922647
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99749891
82	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.99465922
83	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.98179184
84	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94768420
85	GATA3_26560356_Chip-Seq_TH1_Human	0.93332545
86	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.93217905
87	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.92823363
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.91467737
89	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.89789490
90	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.89571771
91	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.87844159
92	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.87741748
93	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.87624938
94	AR_20517297_ChIP-Seq_VCAP_Human	0.86858295
95	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.86271541
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.86270602
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.83872942
98	BCAT_22108803_ChIP-Seq_LS180_Human	0.83650644
99	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.83285266
100	GATA3_26560356_Chip-Seq_TH2_Human	0.82228503

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.25044143
2	MP0002163_abnormal_gland_morphology	3.03373390
3	MP0004885_abnormal_endolymph	3.02101856
4	MP0003646_muscle_fatigue	2.96824616
5	MP0005646_abnormal_pituitary_gland	2.89625316
6	MP0008877_abnormal_DNA_methylation	2.83972459
7	MP0008875_abnormal_xenobiotic_pharmacok	2.81076190
8	MP0005075_abnormal_melanosome_morpholog	2.79314564
9	MP0009379_abnormal_foot_pigmentation	2.74530365
10	MP0001529_abnormal_vocalization	2.63419865
11	MP0002876_abnormal_thyroid_physiology	2.46847150
12	MP0001968_abnormal_touch/_nociception	2.38785115
13	MP0006292_abnormal_olfactory_placode	2.35417223
14	MP0003011_delayed_dark_adaptation	2.27087271
15	MP0005551_abnormal_eye_electrophysiolog	2.26291332
16	MP0002102_abnormal_ear_morphology	2.20747373
17	MP0009780_abnormal_chondrocyte_physiolo	2.17576105
18	MP0005671_abnormal_response_to	2.11251884
19	MP0004142_abnormal_muscle_tone	1.98435728
20	MP0008058_abnormal_DNA_repair	1.86071765
21	MP0009053_abnormal_anal_canal	1.78362200
22	MP0001501_abnormal_sleep_pattern	1.73159108
23	MP0001919_abnormal_reproductive_system	1.66975518
24	MP0008872_abnormal_physiological_respon	1.63378651
25	MP0003806_abnormal_nucleotide_metabolis	1.55315733
26	MP0003787_abnormal_imprinting	1.54476620
27	MP0005379_endocrine/exocrine_gland_phen	1.52988277
28	MP0009745_abnormal_behavioral_response	1.51234369
29	MP0006035_abnormal_mitochondrial_morpho	1.48938819
30	MP0006072_abnormal_retinal_apoptosis	1.45592967
31	MP0003638_abnormal_response/metabolism_	1.45371746
32	MP0005645_abnormal_hypothalamus_physiol	1.44393042
33	MP0005389_reproductive_system_phenotype	1.40966399
34	MP0004043_abnormal_pH_regulation	1.39784506
35	MP0002653_abnormal_ependyma_morphology	1.38365060
36	MP0000685_abnormal_immune_system	1.38216635
37	MP0000427_abnormal_hair_cycle	1.37239495
38	MP0001835_abnormal_antigen_presentation	1.36500927
39	MP0004381_abnormal_hair_follicle	1.35228578
40	MP0001905_abnormal_dopamine_level	1.31111507
41	MP0002733_abnormal_thermal_nociception	1.29831803
42	MP0008789_abnormal_olfactory_epithelium	1.29703419
43	MP0001984_abnormal_olfaction	1.29291212
44	MP0006054_spinal_hemorrhage	1.27093792
45	MP0006276_abnormal_autonomic_nervous	1.23656273
46	MP0001764_abnormal_homeostasis	1.22548026
47	MP0002272_abnormal_nervous_system	1.22271590
48	MP0001970_abnormal_pain_threshold	1.16328341
49	MP0009764_decreased_sensitivity_to	1.15186774
50	MP0001800_abnormal_humoral_immune	1.11901261
51	MP0002148_abnormal_hypersensitivity_rea	1.11242743
52	MP0005360_urolithiasis	1.10079453
53	MP0003567_abnormal_fetal_cardiomyocyte	1.07308689
54	MP0000383_abnormal_hair_follicle	1.04201662
55	MP0005647_abnormal_sex_gland	1.03897939
56	MP0001664_abnormal_digestion	1.03358822
57	MP0006036_abnormal_mitochondrial_physio	1.02274842
58	MP0005253_abnormal_eye_physiology	1.00930734
59	MP0003195_calcinosis	1.00432279
60	MP0002160_abnormal_reproductive_system	0.99800565
61	MP0001486_abnormal_startle_reflex	0.97750038
62	MP0000013_abnormal_adipose_tissue	0.94955023
63	MP0002837_dystrophic_cardiac_calcinosis	0.93670095
64	MP0003329_amyloid_beta_deposits	0.90998962
65	MP0002234_abnormal_pharynx_morphology	0.90006534
66	MP0002736_abnormal_nociception_after	0.89897353
67	MP0005387_immune_system_phenotype	0.89879601
68	MP0001790_abnormal_immune_system	0.89879601
69	MP0008775_abnormal_heart_ventricle	0.88322933
70	MP0000372_irregular_coat_pigmentation	0.83800716
71	MP0003880_abnormal_central_pattern	0.82557597
72	MP0002229_neurodegeneration	0.81955248
73	MP0004264_abnormal_extraembryonic_tissu	0.81240964
74	MP0002723_abnormal_immune_serum	0.80406494
75	MP0005174_abnormal_tail_pigmentation	0.80198305
76	MP0002572_abnormal_emotion/affect_behav	0.79955663
77	MP0004924_abnormal_behavior	0.78924939
78	MP0005386_behavior/neurological_phenoty	0.78924939
79	MP0005000_abnormal_immune_tolerance	0.77704867
80	MP0008873_increased_physiological_sensi	0.75713233
81	MP0005195_abnormal_posterior_eye	0.75644186
82	MP0001661_extended_life_span	0.75340701
83	MP0005410_abnormal_fertilization	0.75017239
84	MP0000647_abnormal_sebaceous_gland	0.74527179
85	MP0002064_seizures	0.74225803
86	MP0001324_abnormal_eye_pigmentation	0.73893425
87	MP0002420_abnormal_adaptive_immunity	0.73773063
88	MP0002210_abnormal_sex_determination	0.73170470
89	MP0009333_abnormal_splenocyte_physiolog	0.73069959
90	MP0009046_muscle_twitch	0.72934924
91	MP0000631_abnormal_neuroendocrine_gland	0.72747309
92	MP0001819_abnormal_immune_cell	0.71830744
93	MP0002452_abnormal_antigen_presenting	0.70767533
94	MP0005377_hearing/vestibular/ear_phenot	0.69885727
95	MP0003878_abnormal_ear_physiology	0.69885727
96	MP0001145_abnormal_male_reproductive	0.68406222
97	MP0003718_maternal_effect	0.67598431
98	MP0000026_abnormal_inner_ear	0.66055370
99	MP0001986_abnormal_taste_sensitivity	0.65459067
100	MP0000049_abnormal_middle_ear	0.65164472

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.92364099
2	Acute necrotizing encephalopathy (HP:0006965)	4.71175749
3	Stomatitis (HP:0010280)	4.61965960
4	Congenital stationary night blindness (HP:0007642)	4.26320363
5	Acute encephalopathy (HP:0006846)	4.10974684
6	Hepatocellular necrosis (HP:0001404)	4.03205598
7	Abnormal mitochondria in muscle tissue (HP:0008316)	4.00477053
8	Thyroid-stimulating hormone excess (HP:0002925)	3.99832148
9	Mitochondrial inheritance (HP:0001427)	3.86590219
10	Progressive macrocephaly (HP:0004481)	3.84356172
11	Increased CSF lactate (HP:0002490)	3.79659364
12	Increased IgM level (HP:0003496)	3.58842367
13	Type II lissencephaly (HP:0007260)	3.55098761
14	Hepatic necrosis (HP:0002605)	3.41392453
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.37414359
16	Cerebral edema (HP:0002181)	3.23916643
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.17008620
18	Large for gestational age (HP:0001520)	3.05736054
19	Poor head control (HP:0002421)	3.05474891
20	Cerebellar dysplasia (HP:0007033)	3.00671548
21	Attenuation of retinal blood vessels (HP:0007843)	3.00486769
22	Dyschromatopsia (HP:0007641)	2.97380145
23	Central scotoma (HP:0000603)	2.88978997
24	Increased serum lactate (HP:0002151)	2.82488469
25	Optic disc pallor (HP:0000543)	2.79290916
26	IgG deficiency (HP:0004315)	2.71730802
27	Abnormality of macular pigmentation (HP:0008002)	2.71028983
28	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.66729567
29	Nonprogressive disorder (HP:0003680)	2.64109572
30	Molar tooth sign on MRI (HP:0002419)	2.58514145
31	Abnormality of midbrain morphology (HP:0002418)	2.58514145
32	Abnormality of incisor morphology (HP:0011063)	2.58070749
33	Congenital ichthyosiform erythroderma (HP:0007431)	2.51568126
34	Lipid accumulation in hepatocytes (HP:0006561)	2.51219597
35	Papilledema (HP:0001085)	2.40759168
36	Abolished electroretinogram (ERG) (HP:0000550)	2.40754777
37	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.32367647
38	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.27545586
39	Severe muscular hypotonia (HP:0006829)	2.26485813
40	Lactic acidosis (HP:0003128)	2.23673911
41	Increased hepatocellular lipid droplets (HP:0006565)	2.23490862
42	Exercise intolerance (HP:0003546)	2.16643859
43	Nephronophthisis (HP:0000090)	2.14267422
44	Abnormality of the ileum (HP:0001549)	2.13347031
45	Intestinal atresia (HP:0011100)	2.11737415
46	Hypomagnesemia (HP:0002917)	2.11080795
47	Microvesicular hepatic steatosis (HP:0001414)	2.08260819
48	Squamous cell carcinoma (HP:0002860)	2.07919057
49	Abnormality of magnesium homeostasis (HP:0004921)	2.06734371
50	Abnormality of cells of the erythroid lineage (HP:0012130)	2.04465363
51	Constricted visual fields (HP:0001133)	2.04043947
52	Hypothermia (HP:0002045)	2.01120882
53	Sclerocornea (HP:0000647)	1.98999769
54	Tubular atrophy (HP:0000092)	1.98106381
55	Volvulus (HP:0002580)	1.97848793
56	Abnormal hair laboratory examination (HP:0003328)	1.97119999
57	Lethargy (HP:0001254)	1.96777365
58	Aplasia/hypoplasia of the uterus (HP:0008684)	1.96145213
59	Respiratory failure (HP:0002878)	1.95989122
60	Decreased central vision (HP:0007663)	1.95457798
61	Pancreatic cysts (HP:0001737)	1.94353314
62	Tetany (HP:0001281)	1.93857319
63	Absent thumb (HP:0009777)	1.92598835
64	Brittle hair (HP:0002299)	1.91266399
65	Abnormality of the renal medulla (HP:0100957)	1.90277248
66	Hypoplasia of the pons (HP:0012110)	1.90154012
67	Lissencephaly (HP:0001339)	1.88223261
68	Leukodystrophy (HP:0002415)	1.87541488
69	Abnormality of the vitreous humor (HP:0004327)	1.86707832
70	Concave nail (HP:0001598)	1.86283573
71	Abnormal number of erythroid precursors (HP:0012131)	1.86262558
72	Visual hallucinations (HP:0002367)	1.86201199
73	Ketosis (HP:0001946)	1.84313672
74	Hypoplasia of the radius (HP:0002984)	1.83864760
75	Abnormality of the pons (HP:0007361)	1.83280011
76	Chorioretinal atrophy (HP:0000533)	1.82551179
77	Birth length less than 3rd percentile (HP:0003561)	1.80080927
78	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.77958829
79	IgA deficiency (HP:0002720)	1.77934761
80	Increased muscle lipid content (HP:0009058)	1.77926885
81	Abnormality of the aortic arch (HP:0012303)	1.77548368
82	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.76110058
83	Hypoplasia of the fovea (HP:0007750)	1.76110058
84	Type I transferrin isoform profile (HP:0003642)	1.74835025
85	Progressive microcephaly (HP:0000253)	1.73749017
86	Scotoma (HP:0000575)	1.73537443
87	Abnormality of the renal cortex (HP:0011035)	1.73163472
88	Reticulocytopenia (HP:0001896)	1.70844338
89	Conical tooth (HP:0000698)	1.69587158
90	Medial flaring of the eyebrow (HP:0010747)	1.69086331
91	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.68940928
92	Rib fusion (HP:0000902)	1.68470759
93	Meckel diverticulum (HP:0002245)	1.66521941
94	Elevated erythrocyte sedimentation rate (HP:0003565)	1.65198375
95	Abnormality of the nasal septum (HP:0000419)	1.65092317
96	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.64857494
97	Gaze-evoked nystagmus (HP:0000640)	1.64696326
98	Congenital, generalized hypertrichosis (HP:0004540)	1.63706565
99	Renal dysplasia (HP:0000110)	1.62786494
100	Increased intramyocellular lipid droplets (HP:0012240)	1.61897134

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	7.35281598
2	ADRBK2	4.31403988
3	FRK	3.21679438
4	MAP3K12	3.15089333
5	MAP4K2	2.81853187
6	WNK3	2.58833389
7	EIF2AK1	2.52998478
8	NUAK1	2.33275791
9	GRK1	2.24126384
10	PINK1	1.97520361
11	TLK1	1.72249922
12	WNK4	1.70955724
13	PLK4	1.67316616
14	ZAK	1.62165512
15	BMPR1B	1.54874808
16	IKBKB	1.49423995
17	MAP4K1	1.48961216
18	DAPK2	1.35660681
19	ADRBK1	1.34329098
20	ILK	1.29333838
21	MARK3	1.27962596
22	TGFBR1	1.27538299
23	PIK3CA	1.26108147
24	MST4	1.24642051
25	DAPK3	1.18310058
26	KIT	1.15727494
27	PKN1	1.10538756
28	MYLK	1.08423366
29	TEC	1.03361837
30	PAK6	1.02621588
31	TXK	0.99059274
32	PLK2	0.99002587
33	TIE1	0.98258060
34	DYRK1B	0.91999577
35	STK39	0.91357582
36	MAPK13	0.89509298
37	VRK2	0.88936534
38	PRKCG	0.87522100
39	BUB1	0.87481386
40	PHKG2	0.87141905
41	PHKG1	0.87141905
42	INSRR	0.86870021
43	NME2	0.84188140
44	CDK19	0.84115778
45	ITK	0.79324032
46	LRRK2	0.78025259
47	SYK	0.78013040
48	PRKCI	0.77598981
49	FLT3	0.74093614
50	PRKCE	0.73733556
51	DAPK1	0.72736712
52	TGFBR2	0.72510711
53	CDK8	0.72371690
54	TYRO3	0.67979048
55	VRK1	0.66930564
56	ERBB3	0.65192522
57	CAMK1	0.64897162
58	DYRK2	0.61219585
59	CSF1R	0.60460111
60	PRKD2	0.60345582
61	WEE1	0.59704774
62	OXSR1	0.57528840
63	PRKAA2	0.56138052
64	CHUK	0.56104156
65	IRAK1	0.56060926
66	MATK	0.55466975
67	RPS6KA5	0.55412638
68	BTK	0.53327616
69	ACVR1B	0.53212199
70	PRKCH	0.51073227
71	PRKCQ	0.49113268
72	PDK2	0.48085968
73	PRKD3	0.47898549
74	PIM2	0.47805978
75	NME1	0.47097676
76	AURKB	0.46830229
77	STK24	0.45663524
78	LYN	0.44505804
79	PRKCA	0.44366212
80	EIF2AK2	0.44274969
81	RPS6KA6	0.43580456
82	PTK2B	0.43347662
83	IGF1R	0.42696235
84	CSNK2A2	0.41874258
85	PRKCD	0.41798803
86	CAMK2A	0.40230974
87	PRKACA	0.38897517
88	PAK3	0.38039750
89	RPS6KA1	0.37623326
90	STK11	0.37329604
91	CAMK2D	0.36585811
92	STK16	0.35974395
93	EIF2AK3	0.35900097
94	FGR	0.34904588
95	MAP2K2	0.34238041
96	GRK5	0.33834854
97	CSNK2A1	0.33619501
98	MAPKAPK5	0.32837790
99	PLK1	0.32472473
100	MOS	0.31655093

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.31841988
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.47850634
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.12999137
4	Asthma_Homo sapiens_hsa05310	3.05760574
5	Parkinsons disease_Homo sapiens_hsa05012	2.74185808
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.62866235
7	Proteasome_Homo sapiens_hsa03050	2.59944137
8	Allograft rejection_Homo sapiens_hsa05330	2.36538407
9	RNA degradation_Homo sapiens_hsa03018	2.25947487
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.09316829
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.03631543
12	Huntingtons disease_Homo sapiens_hsa05016	1.98718675
13	Alzheimers disease_Homo sapiens_hsa05010	1.97866649
14	RNA polymerase_Homo sapiens_hsa03020	1.94584906
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.93466021
16	Phototransduction_Homo sapiens_hsa04744	1.88018639
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.86490395
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79811268
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.79312041
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.77950006
21	Basal transcription factors_Homo sapiens_hsa03022	1.69657080
22	Homologous recombination_Homo sapiens_hsa03440	1.64451748
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.61879968
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.61165991
25	Sulfur relay system_Homo sapiens_hsa04122	1.54612826
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.53085701
27	Type I diabetes mellitus_Homo sapiens_hsa04940	1.52305376
28	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.48064957
29	Protein export_Homo sapiens_hsa03060	1.46712605
30	Graft-versus-host disease_Homo sapiens_hsa05332	1.42938588
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.33703200
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.30549733
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30310609
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25169011
35	Caffeine metabolism_Homo sapiens_hsa00232	1.24775064
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.18574405
37	One carbon pool by folate_Homo sapiens_hsa00670	1.17614595
38	Taste transduction_Homo sapiens_hsa04742	1.15686299
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.14854388
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.12495372
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.09376183
42	Sulfur metabolism_Homo sapiens_hsa00920	1.05923390
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.03141030
44	Base excision repair_Homo sapiens_hsa03410	1.01225749
45	Olfactory transduction_Homo sapiens_hsa04740	1.00606321
46	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00429591
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.98176125
48	Nicotine addiction_Homo sapiens_hsa05033	0.97027039
49	Retinol metabolism_Homo sapiens_hsa00830	0.92835850
50	Rheumatoid arthritis_Homo sapiens_hsa05323	0.92701912
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.90853790
52	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.89424723
53	Arginine biosynthesis_Homo sapiens_hsa00220	0.86533437
54	Mismatch repair_Homo sapiens_hsa03430	0.80860894
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78759610
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76783267
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.73390621
58	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71138644
59	Purine metabolism_Homo sapiens_hsa00230	0.69485537
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68859774
61	Peroxisome_Homo sapiens_hsa04146	0.68724632
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66817155
63	Metabolic pathways_Homo sapiens_hsa01100	0.65511450
64	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.64928512
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63787951
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.61396199
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60936861
68	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.60793272
69	Butanoate metabolism_Homo sapiens_hsa00650	0.59281048
70	Antigen processing and presentation_Homo sapiens_hsa04612	0.58994192
71	Viral myocarditis_Homo sapiens_hsa05416	0.58840641
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57021461
73	Propanoate metabolism_Homo sapiens_hsa00640	0.56244225
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53639899
75	RNA transport_Homo sapiens_hsa03013	0.52284454
76	DNA replication_Homo sapiens_hsa03030	0.50014634
77	Morphine addiction_Homo sapiens_hsa05032	0.49607330
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48930949
79	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.48686309
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.45355388
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.40580394
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40038613
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39731665
84	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.38470928
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34726995
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34510238
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.33446011
88	Circadian rhythm_Homo sapiens_hsa04710	0.32306039
89	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.32021583
90	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.30649015
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.28748091
92	Fatty acid degradation_Homo sapiens_hsa00071	0.28118056
93	Spliceosome_Homo sapiens_hsa03040	0.27831111
94	Selenocompound metabolism_Homo sapiens_hsa00450	0.27002060
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.26973931
96	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.26012187
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.24951658
98	Regulation of autophagy_Homo sapiens_hsa04140	0.24697505
99	Serotonergic synapse_Homo sapiens_hsa04726	0.24237343
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.23066616

RPL23AP14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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