ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.26744807
2	viral transcription (GO:0019083)	6.13892295
3	ATP synthesis coupled proton transport (GO:0015986)	6.03514733
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.03514733
5	translational termination (GO:0006415)	5.97668352
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.89946985
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.14387537
8	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.06780596
9	cotranslational protein targeting to membrane (GO:0006613)	5.03080553
10	protein targeting to ER (GO:0045047)	5.02742074
11	DNA deamination (GO:0045006)	4.94534564
12	translational elongation (GO:0006414)	4.93963970
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.73957970
14	protein localization to endoplasmic reticulum (GO:0070972)	4.73478518
15	respiratory electron transport chain (GO:0022904)	4.63561770
16	maturation of SSU-rRNA (GO:0030490)	4.62478964
17	electron transport chain (GO:0022900)	4.58120750
18	cellular protein complex disassembly (GO:0043624)	4.40372725
19	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	4.32932783
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.30219423
21	viral life cycle (GO:0019058)	4.27484959
22	translational initiation (GO:0006413)	3.94330752
23	regulation of hypersensitivity (GO:0002883)	3.94111877
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.78599174
25	NADH dehydrogenase complex assembly (GO:0010257)	3.78599174
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.78599174
27	ribosomal large subunit biogenesis (GO:0042273)	3.76745974
28	protein complex biogenesis (GO:0070271)	3.71379505
29	negative regulation of mast cell activation (GO:0033004)	3.68045285
30	ribosomal small subunit biogenesis (GO:0042274)	3.64807974
31	chaperone-mediated protein transport (GO:0072321)	3.62479499
32	mast cell activation (GO:0045576)	3.55819765
33	protein complex disassembly (GO:0043241)	3.54801877
34	negative regulation of heart rate (GO:0010459)	3.50335396
35	translation (GO:0006412)	3.48101833
36	leukocyte aggregation (GO:0070486)	3.47994370
37	ATP biosynthetic process (GO:0006754)	3.47609830
38	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.46960046
39	hydrogen ion transmembrane transport (GO:1902600)	3.45441043
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.41134511
41	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.40623877
42	activation of MAPKKK activity (GO:0000185)	3.37851711
43	kynurenine metabolic process (GO:0070189)	3.37846308
44	protein targeting to membrane (GO:0006612)	3.36072446
45	macromolecular complex disassembly (GO:0032984)	3.31638807
46	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.30800781
47	positive regulation of mast cell degranulation (GO:0043306)	3.26449717
48	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.26449717
49	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.24431061
50	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.23187965
51	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.18418216
52	tryptophan metabolic process (GO:0006568)	3.18163091
53	proton transport (GO:0015992)	3.13171205
54	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.11626469
55	preassembly of GPI anchor in ER membrane (GO:0016254)	3.10196669
56	nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)	3.09550080
57	hydrogen transport (GO:0006818)	3.05958338
58	indole-containing compound catabolic process (GO:0042436)	3.04633716
59	indolalkylamine catabolic process (GO:0046218)	3.04633716
60	tryptophan catabolic process (GO:0006569)	3.04633716
61	S-adenosylmethionine metabolic process (GO:0046500)	3.03824866
62	positive regulation of protein homodimerization activity (GO:0090073)	3.01575653
63	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.00898647
64	termination of RNA polymerase III transcription (GO:0006386)	3.00898647
65	mRNA catabolic process (GO:0006402)	2.99186307
66	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	2.98177930
67	prenylation (GO:0097354)	2.93023095
68	protein prenylation (GO:0018342)	2.93023095
69	immunoglobulin mediated immune response (GO:0016064)	2.92330564
70	water-soluble vitamin biosynthetic process (GO:0042364)	2.88097502
71	protein neddylation (GO:0045116)	2.84483643
72	positive regulation of mast cell activation (GO:0033005)	2.83963893
73	indolalkylamine metabolic process (GO:0006586)	2.82255652
74	proteasome assembly (GO:0043248)	2.81249952
75	RNA catabolic process (GO:0006401)	2.80712685
76	I-kappaB kinase/NF-kappaB signaling (GO:0007249)	2.80408588
77	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.80092261
78	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.79373802
79	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.77691355
80	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.77691355
81	GTP biosynthetic process (GO:0006183)	2.77572127
82	mast cell activation involved in immune response (GO:0002279)	2.74239974
83	mast cell degranulation (GO:0043303)	2.74239974
84	regulation of triglyceride catabolic process (GO:0010896)	2.74061163
85	GPI anchor biosynthetic process (GO:0006506)	2.72822578
86	piRNA metabolic process (GO:0034587)	2.70676951
87	synapsis (GO:0007129)	2.68220072
88	negative regulation of T cell differentiation in thymus (GO:0033085)	2.67740516
89	respiratory chain complex IV assembly (GO:0008535)	2.67729266
90	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.67330999
91	regulation of B cell receptor signaling pathway (GO:0050855)	2.63523555
92	regulation of germinal center formation (GO:0002634)	2.62496998
93	GPI anchor metabolic process (GO:0006505)	2.58169561
94	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.56682155
95	neutrophil activation involved in immune response (GO:0002283)	2.55314996
96	positive regulation of defense response to virus by host (GO:0002230)	2.53387393
97	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.53115106
98	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.51968698
99	regulation of mast cell activation (GO:0033003)	2.49442153
100	cellular component biogenesis (GO:0044085)	2.48365370

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.41135429
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.24936662
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.17275946
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.14665415
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.98837644
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.90644047
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.86657492
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.80379676
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.58188958
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40020153
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.30553406
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.18607313
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.08161576
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.04152114
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.01531509
16	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.00952903
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.98290538
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.96751335
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.94965546
20	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.94814137
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.94126238
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.93527974
23	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.91650393
24	VDR_22108803_ChIP-Seq_LS180_Human	1.89762756
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.86652249
26	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.76792682
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73685930
28	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.72241271
29	GATA3_26560356_Chip-Seq_TH2_Human	1.69225617
30	STAT1_20625510_ChIP-Seq_HELA_Human	1.65968711
31	AR_20517297_ChIP-Seq_VCAP_Human	1.61501219
32	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.55442555
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.54485598
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.51108896
35	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.51101458
36	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.50289182
37	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.50055396
38	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.49695365
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.49695365
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.48745002
41	ERG_20517297_ChIP-Seq_VCAP_Human	1.43812355
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.43557897
43	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.42006348
44	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.39848839
45	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.39828890
46	TAF2_19829295_ChIP-Seq_ESCs_Human	1.38117052
47	MYB_26560356_Chip-Seq_TH2_Human	1.37621796
48	EZH2_22144423_ChIP-Seq_EOC_Human	1.35299568
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32045397
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28907494
51	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.27309489
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26061238
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26061238
54	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.25539806
55	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.24707396
56	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24613837
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23745096
58	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.23512726
59	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.22887863
60	EWS_26573619_Chip-Seq_HEK293_Human	1.18352797
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17408762
62	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.17391084
63	NCOR_22424771_ChIP-Seq_293T_Human	1.17286315
64	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.16799996
65	FUS_26573619_Chip-Seq_HEK293_Human	1.16798898
66	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16104847
67	P53_21459846_ChIP-Seq_SAOS-2_Human	1.15355894
68	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15123844
69	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14823676
70	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13412475
71	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11392669
72	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.11106968
73	E2F1_20622854_ChIP-Seq_HELA_Human	1.10963738
74	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.09392855
75	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.09027238
76	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08028189
77	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.06850176
78	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.06610971
79	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05444023
80	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.04137345
81	P300_27268052_Chip-Seq_Bcells_Human	1.03584813
82	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.03347073
83	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.03064285
84	RAC3_21632823_ChIP-Seq_H3396_Human	1.02114489
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00643927
86	ER_23166858_ChIP-Seq_MCF-7_Human	1.00001491
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99281293
88	TTF2_22483619_ChIP-Seq_HELA_Human	0.99281016
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98674245
90	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.97539877
91	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97306385
92	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96832316
93	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.96806334
94	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95788262
95	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.95744965
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.95559692
97	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.94271401
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93991261
99	BCL6_27268052_Chip-Seq_Bcells_Human	0.93751666
100	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93643244

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.44712271
2	MP0005671_abnormal_response_to	3.80023307
3	MP0001835_abnormal_antigen_presentation	3.75467957
4	MP0003646_muscle_fatigue	2.60272744
5	MP0003806_abnormal_nucleotide_metabolis	2.38477130
6	MP0005623_abnormal_meninges_morphology	2.23557826
7	MP0008875_abnormal_xenobiotic_pharmacok	2.23490852
8	MP0001800_abnormal_humoral_immune	2.17843997
9	MP0009764_decreased_sensitivity_to	2.14192986
10	MP0002148_abnormal_hypersensitivity_rea	2.05663219
11	MP0008877_abnormal_DNA_methylation	2.03372662
12	MP0004147_increased_porphyrin_level	2.00889306
13	MP0008872_abnormal_physiological_respon	1.99006809
14	MP0009785_altered_susceptibility_to	1.92949125
15	MP0003724_increased_susceptibility_to	1.90558989
16	MP0005551_abnormal_eye_electrophysiolog	1.90379209
17	MP0002102_abnormal_ear_morphology	1.86375127
18	MP0006292_abnormal_olfactory_placode	1.86300588
19	MP0001873_stomach_inflammation	1.84429721
20	MP0005000_abnormal_immune_tolerance	1.83159960
21	MP0002837_dystrophic_cardiac_calcinosis	1.78585849
22	MP0005646_abnormal_pituitary_gland	1.72826171
23	MP0009333_abnormal_splenocyte_physiolog	1.72181780
24	MP0003786_premature_aging	1.68680108
25	MP0000685_abnormal_immune_system	1.67672519
26	MP0000372_irregular_coat_pigmentation	1.66296219
27	MP0003866_abnormal_defecation	1.65160251
28	MP0004885_abnormal_endolymph	1.61606284
29	MP0002723_abnormal_immune_serum	1.56577095
30	MP0002163_abnormal_gland_morphology	1.55822671
31	MP0002452_abnormal_antigen_presenting	1.54634000
32	MP0002938_white_spotting	1.50663444
33	MP0000750_abnormal_muscle_regeneration	1.47649506
34	MP0008775_abnormal_heart_ventricle	1.37643508
35	MP0002420_abnormal_adaptive_immunity	1.35870443
36	MP0006072_abnormal_retinal_apoptosis	1.34468561
37	MP0001819_abnormal_immune_cell	1.34445929
38	MP0005075_abnormal_melanosome_morpholog	1.32532916
39	MP0005377_hearing/vestibular/ear_phenot	1.32525168
40	MP0003878_abnormal_ear_physiology	1.32525168
41	MP0006036_abnormal_mitochondrial_physio	1.32276111
42	MP0005367_renal/urinary_system_phenotyp	1.29925116
43	MP0000516_abnormal_urinary_system	1.29925116
44	MP0003195_calcinosis	1.27589845
45	MP0002933_joint_inflammation	1.25622664
46	MP0001986_abnormal_taste_sensitivity	1.24675850
47	MP0002277_abnormal_respiratory_mucosa	1.23911986
48	MP0002166_altered_tumor_susceptibility	1.23679248
49	MP0001919_abnormal_reproductive_system	1.21536763
50	MP0002876_abnormal_thyroid_physiology	1.21136508
51	MP0005387_immune_system_phenotype	1.20008561
52	MP0001790_abnormal_immune_system	1.20008561
53	MP0005025_abnormal_response_to	1.18346351
54	MP0005410_abnormal_fertilization	1.17290529
55	MP0003252_abnormal_bile_duct	1.15871301
56	MP0003011_delayed_dark_adaptation	1.15348526
57	MP0003436_decreased_susceptibility_to	1.14477059
58	MP0002095_abnormal_skin_pigmentation	1.14326516
59	MP0000858_altered_metastatic_potential	1.13637209
60	MP0005389_reproductive_system_phenotype	1.13239735
61	MP0008995_early_reproductive_senescence	1.12837449
62	MP0002006_tumorigenesis	1.11972336
63	MP0003763_abnormal_thymus_physiology	1.11379979
64	MP0001845_abnormal_inflammatory_respons	1.08724613
65	MP0005084_abnormal_gallbladder_morpholo	1.07344259
66	MP0001765_abnormal_ion_homeostasis	1.06634251
67	MP0010155_abnormal_intestine_physiology	1.05382623
68	MP0001905_abnormal_dopamine_level	1.04955494
69	MP0004142_abnormal_muscle_tone	1.04129181
70	MP0005332_abnormal_amino_acid	1.03624046
71	MP0002638_abnormal_pupillary_reflex	1.03232381
72	MP0001485_abnormal_pinna_reflex	1.03128417
73	MP0004145_abnormal_muscle_electrophysio	0.98801170
74	MP0004947_skin_inflammation	0.96421534
75	MP0003186_abnormal_redox_activity	0.96361974
76	MP0001968_abnormal_touch/_nociception	0.94880171
77	MP0005636_abnormal_mineral_homeostasis	0.94536038
78	MP0005503_abnormal_tendon_morphology	0.89832806
79	MP0005253_abnormal_eye_physiology	0.89595085
80	MP0002419_abnormal_innate_immunity	0.88643671
81	MP0004742_abnormal_vestibular_system	0.87460064
82	MP0000716_abnormal_immune_system	0.86577518
83	MP0008469_abnormal_protein_level	0.85466833
84	MP0003638_abnormal_response/metabolism_	0.85091463
85	MP0006082_CNS_inflammation	0.83523924
86	MP0000343_altered_response_to	0.81589656
87	MP0000427_abnormal_hair_cycle	0.81206984
88	MP0009046_muscle_twitch	0.79892309
89	MP0002736_abnormal_nociception_after	0.79330212
90	MP0005645_abnormal_hypothalamus_physiol	0.78736247
91	MP0002398_abnormal_bone_marrow	0.78134736
92	MP0000689_abnormal_spleen_morphology	0.76608227
93	MP0001501_abnormal_sleep_pattern	0.75141501
94	MP0002138_abnormal_hepatobiliary_system	0.75130406
95	MP0002282_abnormal_trachea_morphology	0.73392092
96	MP0009745_abnormal_behavioral_response	0.72703792
97	MP0000230_abnormal_systemic_arterial	0.71874978
98	MP0005319_abnormal_enzyme/_coenzyme	0.71407790
99	MP0000013_abnormal_adipose_tissue	0.69943861
100	MP0002234_abnormal_pharynx_morphology	0.69300011

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	5.60704707
2	Cerebellar dysplasia (HP:0007033)	5.43333433
3	Retinal dysplasia (HP:0007973)	4.98085835
4	Retinal atrophy (HP:0001105)	4.87537672
5	Fatigue (HP:0012378)	4.60018232
6	Acute necrotizing encephalopathy (HP:0006965)	4.41744424
7	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.40413546
8	Abolished electroretinogram (ERG) (HP:0000550)	4.25515870
9	Mitochondrial inheritance (HP:0001427)	4.11692190
10	Congenital, generalized hypertrichosis (HP:0004540)	4.10324915
11	Increased CSF lactate (HP:0002490)	3.90843207
12	Acute encephalopathy (HP:0006846)	3.89455832
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.87779086
14	3-Methylglutaconic aciduria (HP:0003535)	3.87670964
15	Progressive macrocephaly (HP:0004481)	3.69601147
16	Hepatocellular necrosis (HP:0001404)	3.59907196
17	IgG deficiency (HP:0004315)	3.56417826
18	Hypoplasia of the pons (HP:0012110)	3.40112426
19	Abnormality of the pons (HP:0007361)	3.21031436
20	Hepatic necrosis (HP:0002605)	3.06916695
21	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.05202208
22	Pallor (HP:0000980)	2.98308332
23	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.97393254
24	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.93603192
25	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.93603192
26	Abnormality of cells of the erythroid lineage (HP:0012130)	2.78145632
27	Cerebral edema (HP:0002181)	2.68494787
28	Lipid accumulation in hepatocytes (HP:0006561)	2.65910444
29	Increased hepatocellular lipid droplets (HP:0006565)	2.64280362
30	Stomatitis (HP:0010280)	2.56243766
31	Abnormal number of erythroid precursors (HP:0012131)	2.50603524
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.49943023
33	Severe muscular hypotonia (HP:0006829)	2.48800567
34	Optic disc pallor (HP:0000543)	2.47401676
35	Congenital stationary night blindness (HP:0007642)	2.46750034
36	Exertional dyspnea (HP:0002875)	2.44173742
37	Increased IgM level (HP:0003496)	2.40686959
38	Pancreatic cysts (HP:0001737)	2.40646863
39	Macrocytic anemia (HP:0001972)	2.36384835
40	Elevated erythrocyte sedimentation rate (HP:0003565)	2.36122323
41	Renal Fanconi syndrome (HP:0001994)	2.30987970
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.29690668
43	Abnormality of B cell number (HP:0010975)	2.26910436
44	Abnormal hemoglobin (HP:0011902)	2.25471311
45	Abnormality of the prostate (HP:0008775)	2.24022417
46	Lactic acidosis (HP:0003128)	2.18419947
47	Respiratory failure (HP:0002878)	2.17053879
48	B lymphocytopenia (HP:0010976)	2.15397070
49	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.15237156
50	Leukodystrophy (HP:0002415)	2.14174380
51	Increased serum lactate (HP:0002151)	2.12728489
52	Attenuation of retinal blood vessels (HP:0007843)	2.11565809
53	Decreased central vision (HP:0007663)	2.10944123
54	Abnormality of midbrain morphology (HP:0002418)	2.09007779
55	Molar tooth sign on MRI (HP:0002419)	2.09007779
56	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.08921643
57	Absent/shortened dynein arms (HP:0200106)	2.08921643
58	Abnormality of DNA repair (HP:0003254)	2.08285000
59	Hypothermia (HP:0002045)	2.03485979
60	Increased corneal curvature (HP:0100692)	2.03118130
61	Keratoconus (HP:0000563)	2.03118130
62	Increased intramyocellular lipid droplets (HP:0012240)	2.00702289
63	Buphthalmos (HP:0000557)	1.99530973
64	Reticulocytopenia (HP:0001896)	1.99257350
65	Pulmonary infiltrates (HP:0002113)	1.96943188
66	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.96515962
67	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.96473834
68	Pancreatic fibrosis (HP:0100732)	1.96284403
69	Conical tooth (HP:0000698)	1.92511755
70	Lethargy (HP:0001254)	1.89904325
71	Type 2 muscle fiber atrophy (HP:0003554)	1.89878891
72	Methylmalonic acidemia (HP:0002912)	1.88480885
73	CNS demyelination (HP:0007305)	1.88362117
74	True hermaphroditism (HP:0010459)	1.87992122
75	Absent thumb (HP:0009777)	1.86802998
76	Abnormality of the renal cortex (HP:0011035)	1.86572172
77	Abnormality of the vitreous humor (HP:0004327)	1.83497684
78	Pancytopenia (HP:0001876)	1.80456762
79	Increased muscle lipid content (HP:0009058)	1.80243232
80	Delayed CNS myelination (HP:0002188)	1.79718872
81	Mesangial abnormality (HP:0001966)	1.78287626
82	Hypoproteinemia (HP:0003075)	1.78126413
83	Pulmonary fibrosis (HP:0002206)	1.77849608
84	Woolly hair (HP:0002224)	1.77326708
85	Polydipsia (HP:0001959)	1.76563337
86	Abnormal drinking behavior (HP:0030082)	1.76563337
87	Exercise intolerance (HP:0003546)	1.76321651
88	Congenital ichthyosiform erythroderma (HP:0007431)	1.75502805
89	Hyperglycinemia (HP:0002154)	1.75247923
90	Gastrointestinal infarctions (HP:0005244)	1.70262846
91	Optic neuritis (HP:0100653)	1.67179625
92	Retrobulbar optic neuritis (HP:0100654)	1.67179625
93	Asplenia (HP:0001746)	1.66497478
94	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.64908440
95	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.63343708
96	Nephronophthisis (HP:0000090)	1.63260356
97	Pachygyria (HP:0001302)	1.63057264
98	Abnormality of alanine metabolism (HP:0010916)	1.57427864
99	Hyperalaninemia (HP:0003348)	1.57427864
100	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.57427864

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.51380347
2	TXK	3.54127455
3	BMPR2	3.49840444
4	TLK1	3.20894682
5	MARK3	2.85214078
6	STK10	2.81054934
7	MAP3K12	2.56819251
8	GRK1	2.48043542
9	TIE1	2.18469593
10	ZAK	2.16905409
11	CDK19	2.10005283
12	MUSK	2.09369726
13	MAP4K1	2.06884485
14	INSRR	2.02445741
15	FRK	1.94772372
16	MAP4K2	1.93422355
17	ADRBK2	1.83227219
18	CDK8	1.73536106
19	IKBKB	1.73337665
20	NUAK1	1.64918441
21	KIT	1.49646336
22	MYLK	1.44512324
23	PIM1	1.41285988
24	BCKDK	1.40442256
25	OXSR1	1.35224885
26	PTK2B	1.23462936
27	GRK6	1.22750757
28	NME2	1.20782905
29	FLT3	1.19602317
30	TEC	1.17925329
31	RIPK4	1.12773417
32	TRPM7	1.07807556
33	KDR	1.04755438
34	BMPR1B	1.02406487
35	ILK	0.99467988
36	PLK4	0.97481245
37	DAPK1	0.96250571
38	BTK	0.96181624
39	LYN	0.95572264
40	CAMKK2	0.95141227
41	PHKG2	0.95018699
42	PHKG1	0.95018699
43	PIK3CG	0.94392523
44	SYK	0.92080280
45	GRK5	0.91596592
46	JAK3	0.89945614
47	CSF1R	0.89258038
48	STK11	0.89084536
49	MAP3K14	0.83220036
50	FES	0.82167139
51	GRK7	0.79669296
52	DAPK2	0.78184491
53	RPS6KA5	0.77582419
54	WNK4	0.76663749
55	DAPK3	0.76178594
56	BUB1	0.75917026
57	ITK	0.74223764
58	LCK	0.73198427
59	ZAP70	0.69650730
60	PDK2	0.68575087
61	TNK2	0.68322538
62	MAP2K2	0.67191697
63	CDK4	0.67103146
64	CSNK1G3	0.66850215
65	DYRK2	0.64375210
66	IKBKE	0.63608784
67	OBSCN	0.63565780
68	STK16	0.63404685
69	IGF1R	0.61887676
70	MKNK1	0.61799792
71	ADRBK1	0.61419297
72	CHEK2	0.59022028
73	SCYL2	0.55298150
74	PKN1	0.55268311
75	WNK3	0.53852717
76	MAPKAPK5	0.53211132
77	CSNK1A1L	0.51236521
78	ABL2	0.50254412
79	ERBB3	0.49209088
80	PRKCH	0.48718052
81	CSNK1G2	0.47421951
82	MAP2K6	0.47251682
83	PRKCQ	0.45851329
84	AURKB	0.44602611
85	VRK2	0.43460974
86	MATK	0.39915889
87	STK39	0.39602638
88	TGFBR1	0.39335215
89	CSNK1G1	0.39232393
90	PRKCA	0.38337746
91	ROCK1	0.38287207
92	CHUK	0.35990503
93	LIMK1	0.35450119
94	CDC7	0.34972524
95	NEK1	0.34687486
96	PRKACA	0.34460444
97	CSNK2A1	0.33803775
98	EGFR	0.33683996
99	CSNK1D	0.32232172
100	HCK	0.32226335

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.57035284
2	Asthma_Homo sapiens_hsa05310	4.35521864
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.91128377
4	Allograft rejection_Homo sapiens_hsa05330	3.42376863
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.27257536
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.24687772
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.20008070
8	Parkinsons disease_Homo sapiens_hsa05012	3.06774547
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.54208656
10	One carbon pool by folate_Homo sapiens_hsa00670	2.34613487
11	Proteasome_Homo sapiens_hsa03050	2.31532112
12	Alzheimers disease_Homo sapiens_hsa05010	2.23554023
13	Huntingtons disease_Homo sapiens_hsa05016	2.06888258
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.02939733
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.80647942
16	RNA polymerase_Homo sapiens_hsa03020	1.78114171
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.78038615
18	Homologous recombination_Homo sapiens_hsa03440	1.75744176
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68974624
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.66981214
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.66299097
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.64349688
23	Antigen processing and presentation_Homo sapiens_hsa04612	1.62378208
24	Viral myocarditis_Homo sapiens_hsa05416	1.52205379
25	Leishmaniasis_Homo sapiens_hsa05140	1.47920860
26	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.43358564
27	Protein export_Homo sapiens_hsa03060	1.41115680
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.40930897
29	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.25711251
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.21261735
31	RNA degradation_Homo sapiens_hsa03018	1.18996859
32	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.14416877
33	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.14140428
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.03463712
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.03169891
36	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.00697907
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96391960
38	Phototransduction_Homo sapiens_hsa04744	0.91012948
39	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90483373
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.86210995
41	DNA replication_Homo sapiens_hsa03030	0.82547170
42	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81683916
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.76778647
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.76258132
45	Mismatch repair_Homo sapiens_hsa03430	0.72126161
46	Basal transcription factors_Homo sapiens_hsa03022	0.72069285
47	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.71941925
48	Toxoplasmosis_Homo sapiens_hsa05145	0.71538087
49	Olfactory transduction_Homo sapiens_hsa04740	0.67634214
50	Caffeine metabolism_Homo sapiens_hsa00232	0.67114709
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.66052710
52	Sulfur metabolism_Homo sapiens_hsa00920	0.65877101
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.65658082
54	Purine metabolism_Homo sapiens_hsa00230	0.65371338
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.64121761
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62350919
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61404883
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.61283294
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57569852
60	Herpes simplex infection_Homo sapiens_hsa05168	0.55203524
61	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.54927136
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54054858
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53037555
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.52318599
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49677626
66	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49041077
67	Base excision repair_Homo sapiens_hsa03410	0.48781457
68	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.48734163
69	Metabolic pathways_Homo sapiens_hsa01100	0.47381888
70	Spliceosome_Homo sapiens_hsa03040	0.41881362
71	Glutathione metabolism_Homo sapiens_hsa00480	0.40682189
72	Tuberculosis_Homo sapiens_hsa05152	0.37107056
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36354467
74	Peroxisome_Homo sapiens_hsa04146	0.36223053
75	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.35570965
76	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.32434353
77	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.32386961
78	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.32341237
79	Retinol metabolism_Homo sapiens_hsa00830	0.32090919
80	RNA transport_Homo sapiens_hsa03013	0.30214866
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.29751553
82	Regulation of autophagy_Homo sapiens_hsa04140	0.28238185
83	Malaria_Homo sapiens_hsa05144	0.28058068
84	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.27638627
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.27602937
86	Nicotine addiction_Homo sapiens_hsa05033	0.26204366
87	Phagosome_Homo sapiens_hsa04145	0.25997326
88	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.24826750
89	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.24248096
90	Taste transduction_Homo sapiens_hsa04742	0.23681123
91	Sulfur relay system_Homo sapiens_hsa04122	0.21028119
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.20132528
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.19776102
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.18746847
95	Salivary secretion_Homo sapiens_hsa04970	0.18042393
96	TNF signaling pathway_Homo sapiens_hsa04668	0.17799076
97	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.17173107
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.16182038
99	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.15549239
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.13640460

RPL23AP15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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