ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nucleoside transmembrane transport (GO:1901642)	8.46852502
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.34455622
3	ATP synthesis coupled proton transport (GO:0015986)	7.34455622
4	ribosomal small subunit biogenesis (GO:0042274)	7.06104437
5	nucleoside transport (GO:0015858)	6.62213776
6	DNA deamination (GO:0045006)	6.53883025
7	viral transcription (GO:0019083)	6.40672489
8	translational termination (GO:0006415)	6.05238239
9	translational elongation (GO:0006414)	5.83728427
10	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	5.52789251
11	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	5.31766611
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.20973666
13	cotranslational protein targeting to membrane (GO:0006613)	5.11382725
14	interferon-gamma production (GO:0032609)	5.10429649
15	protein targeting to ER (GO:0045047)	5.07338275
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.97628262
17	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.84442053
18	protein localization to endoplasmic reticulum (GO:0070972)	4.75818501
19	regulation of mitochondrial membrane potential (GO:0051881)	4.56906349
20	cellular protein complex disassembly (GO:0043624)	4.52330509
21	viral life cycle (GO:0019058)	4.52069579
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.45602834
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.45602834
24	outer ear morphogenesis (GO:0042473)	4.44381391
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.41092845
26	cofactor transport (GO:0051181)	4.35195024
27	ribosomal small subunit assembly (GO:0000028)	4.27160605
28	ATP biosynthetic process (GO:0006754)	4.24769394
29	nucleotide-sugar biosynthetic process (GO:0009226)	4.23269077
30	pantothenate metabolic process (GO:0015939)	4.15943110
31	translational initiation (GO:0006413)	4.10668918
32	coenzyme A biosynthetic process (GO:0015937)	4.09973145
33	translation (GO:0006412)	4.09825543
34	modified amino acid transport (GO:0072337)	4.02161119
35	respiratory electron transport chain (GO:0022904)	3.97546325
36	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.94513053
37	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.90195489
38	electron transport chain (GO:0022900)	3.89868071
39	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.84486663
40	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.84060121
41	reproduction (GO:0000003)	3.83222474
42	cytidine deamination (GO:0009972)	3.81717481
43	cytidine metabolic process (GO:0046087)	3.81717481
44	cytidine catabolic process (GO:0006216)	3.81717481
45	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.79166824
46	protein neddylation (GO:0045116)	3.73846534
47	protein targeting to membrane (GO:0006612)	3.72539512
48	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.67374451
49	protein complex disassembly (GO:0043241)	3.64188014
50	cellular component biogenesis (GO:0044085)	3.63531921
51	peroxisome fission (GO:0016559)	3.57023084
52	maturation of SSU-rRNA (GO:0030490)	3.51190537
53	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.50954959
54	ribonucleoprotein complex biogenesis (GO:0022613)	3.50682293
55	positive regulation of icosanoid secretion (GO:0032305)	3.48860763
56	negative regulation of cAMP-mediated signaling (GO:0043951)	3.48835139
57	cellular response to estradiol stimulus (GO:0071392)	3.47499506
58	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.46327402
59	ribosomal large subunit biogenesis (GO:0042273)	3.44887953
60	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.42871484
61	macromolecular complex disassembly (GO:0032984)	3.41758158
62	positive regulation of fatty acid transport (GO:2000193)	3.39629563
63	short-chain fatty acid metabolic process (GO:0046459)	3.38476222
64	water-soluble vitamin biosynthetic process (GO:0042364)	3.30406778
65	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.29599838
66	response to misfolded protein (GO:0051788)	3.28506908
67	mRNA catabolic process (GO:0006402)	3.26598042
68	response to pheromone (GO:0019236)	3.16146473
69	sulfur compound transport (GO:0072348)	3.11245820
70	aerobic respiration (GO:0009060)	3.11002435
71	positive regulation of transcription regulatory region DNA binding (GO:2000679)	3.09664231
72	hydrogen ion transmembrane transport (GO:1902600)	3.05656691
73	protein deneddylation (GO:0000338)	3.03930138
74	homocysteine metabolic process (GO:0050667)	2.99525841
75	regulation of receptor binding (GO:1900120)	2.99349092
76	GTP biosynthetic process (GO:0006183)	2.98701309
77	intracellular protein transmembrane import (GO:0044743)	2.96699673
78	positive regulation of protein kinase C signaling (GO:0090037)	2.95064876
79	nucleoside triphosphate biosynthetic process (GO:0009142)	2.92597302
80	cytochrome complex assembly (GO:0017004)	2.92282343
81	endoderm formation (GO:0001706)	2.92005787
82	respiratory chain complex IV assembly (GO:0008535)	2.91314548
83	RNA catabolic process (GO:0006401)	2.89603785
84	guanosine-containing compound biosynthetic process (GO:1901070)	2.88230880
85	positive regulation of fatty acid oxidation (GO:0046321)	2.81368141
86	lateral ventricle development (GO:0021670)	2.80143258
87	purine ribonucleoside biosynthetic process (GO:0046129)	2.78938433
88	purine nucleoside biosynthetic process (GO:0042451)	2.78938433
89	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)	2.75866715
90	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.73391164
91	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.73391164
92	peripheral nervous system neuron development (GO:0048935)	2.73385576
93	carbohydrate derivative transport (GO:1901264)	2.72399207
94	rRNA processing (GO:0006364)	2.71689003
95	maturation of 5.8S rRNA (GO:0000460)	2.69998863
96	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.69970193
97	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.69970193
98	chaperone-mediated protein transport (GO:0072321)	11.9314272
99	GDP-mannose metabolic process (GO:0019673)	10.2438016
100	mannose metabolic process (GO:0006013)	10.2362748

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	6.36165325
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	5.76281465
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.29403677
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.31886228
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.29458830
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.12996902
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.01384941
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.82379140
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.66599012
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.44067006
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.43066782
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.33380309
13	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.33127099
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.32085419
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.26516006
16	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.13445403
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.07805952
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.94656915
19	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.92117608
20	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.89088749
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86887240
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.86511939
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.83377692
24	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.77871339
25	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.76027164
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.70151966
27	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.68248505
28	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.62790506
29	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.62790506
30	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.62790506
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.61580600
32	VDR_22108803_ChIP-Seq_LS180_Human	1.60158377
33	KDM5A_27292631_Chip-Seq_BREAST_Human	1.59103263
34	XRN2_22483619_ChIP-Seq_HELA_Human	1.57477228
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.56114198
36	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.50870105
37	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.47241673
38	STAT1_20625510_ChIP-Seq_HELA_Human	1.47047498
39	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.40989339
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38191916
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.37150907
42	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.36950442
43	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.36733015
44	RBPJ_21746931_ChIP-Seq_IB4_Human	1.31546893
45	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.30843988
46	PHF8_20622853_ChIP-Seq_HELA_Human	1.29425371
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.27551571
48	EGR1_19032775_ChIP-ChIP_M12_Human	1.24034008
49	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.23856806
50	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.23419258
51	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.21109189
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20949531
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.20451168
54	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.20433289
55	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.20257085
56	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.16144400
57	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.15956334
58	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.15058066
59	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.14945531
60	ETV1_20927104_ChIP-Seq_GIST48_Human	1.14071272
61	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.13442858
62	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.13378194
63	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12026135
64	SA1_27219007_Chip-Seq_Bcells_Human	1.11937513
65	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.11153714
66	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.10893541
67	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.10828777
68	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.09442912
69	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07836721
70	E2F1_20622854_ChIP-Seq_HELA_Human	1.06840874
71	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.06044101
72	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.05006298
73	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04461402
74	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.03202313
75	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.03035552
76	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.02926370
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.02539733
78	TTF2_22483619_ChIP-Seq_HELA_Human	1.02090844
79	GABP_19822575_ChIP-Seq_HepG2_Human	1.01829757
80	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.99489603
81	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99289050
82	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97468115
83	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.97315668
84	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.97071538
85	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.95311484
86	EWS_26573619_Chip-Seq_HEK293_Human	0.94535463
87	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.94172238
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.93671982
89	DCP1A_22483619_ChIP-Seq_HELA_Human	0.93584647
90	RUNX_20019798_ChIP-Seq_JUKART_Human	0.93213257
91	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.92874314
92	RNF2_27304074_Chip-Seq_NSC_Mouse	0.92434391
93	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.89976346
94	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89703771
95	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.89527590
96	NCOR_22424771_ChIP-Seq_293T_Human	0.88306262
97	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.88049307
98	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87822755
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.87590786
100	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.87590786

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002638_abnormal_pupillary_reflex	6.12279242
2	MP0009379_abnormal_foot_pigmentation	4.73487827
3	MP0003646_muscle_fatigue	3.92233490
4	MP0005671_abnormal_response_to	3.62663171
5	MP0006072_abnormal_retinal_apoptosis	2.86220570
6	MP0001727_abnormal_embryo_implantation	2.50161041
7	MP0002163_abnormal_gland_morphology	2.26901383
8	MP0005387_immune_system_phenotype	2.12630677
9	MP0001790_abnormal_immune_system	2.12630677
10	MP0008875_abnormal_xenobiotic_pharmacok	2.11874715
11	MP0004043_abnormal_pH_regulation	2.07271531
12	MP0005646_abnormal_pituitary_gland	1.99703270
13	MP0000678_abnormal_parathyroid_gland	1.93191664
14	MP0004858_abnormal_nervous_system	1.88162384
15	MP0001835_abnormal_antigen_presentation	1.86124216
16	MP0000015_abnormal_ear_pigmentation	1.85056503
17	MP0002160_abnormal_reproductive_system	1.79263044
18	MP0001542_abnormal_bone_strength	1.74430582
19	MP0001529_abnormal_vocalization	1.64360104
20	MP0009333_abnormal_splenocyte_physiolog	1.62836441
21	MP0002837_dystrophic_cardiac_calcinosis	1.62472176
22	MP0003693_abnormal_embryo_hatching	1.59226151
23	MP0005389_reproductive_system_phenotype	1.59100882
24	MP0008260_abnormal_autophagy	1.58539775
25	MP0004133_heterotaxia	1.56262747
26	MP0005377_hearing/vestibular/ear_phenot	1.49152325
27	MP0003878_abnormal_ear_physiology	1.49152325
28	MP0005379_endocrine/exocrine_gland_phen	1.44837027
29	MP0006292_abnormal_olfactory_placode	1.44202493
30	MP0009250_abnormal_appendicular_skeleto	1.42777159
31	MP0000685_abnormal_immune_system	1.42335490
32	MP0001905_abnormal_dopamine_level	1.37202323
33	MP0004885_abnormal_endolymph	1.32985177
34	MP0005360_urolithiasis	1.32876050
35	MP0009785_altered_susceptibility_to	1.32096495
36	MP0004145_abnormal_muscle_electrophysio	1.29032336
37	MP0000049_abnormal_middle_ear	1.28176443
38	MP0004147_increased_porphyrin_level	1.22652386
39	MP0003763_abnormal_thymus_physiology	1.21949105
40	MP0005464_abnormal_platelet_physiology	1.19937232
41	MP0005000_abnormal_immune_tolerance	1.19855695
42	MP0001919_abnormal_reproductive_system	1.14843042
43	MP0002148_abnormal_hypersensitivity_rea	1.13847127
44	MP0001800_abnormal_humoral_immune	1.13819258
45	MP0005174_abnormal_tail_pigmentation	1.09422914
46	MP0009764_decreased_sensitivity_to	1.08293459
47	MP0002095_abnormal_skin_pigmentation	1.04345970
48	MP0001881_abnormal_mammary_gland	1.04342708
49	MP0008872_abnormal_physiological_respon	1.04248154
50	MP0001968_abnormal_touch/_nociception	1.03553576
51	MP0006036_abnormal_mitochondrial_physio	1.01899531
52	MP0002398_abnormal_bone_marrow	1.01884206
53	MP0001986_abnormal_taste_sensitivity	1.01672477
54	MP0003879_abnormal_hair_cell	0.99854053
55	MP0001188_hyperpigmentation	0.99779882
56	MP0002723_abnormal_immune_serum	0.99540402
57	MP0000372_irregular_coat_pigmentation	0.99225151
58	MP0002420_abnormal_adaptive_immunity	0.98338622
59	MP0005503_abnormal_tendon_morphology	0.98043292
60	MP0004142_abnormal_muscle_tone	0.97369492
61	MP0000343_altered_response_to	0.96590452
62	MP0001819_abnormal_immune_cell	0.95652902
63	MP0001873_stomach_inflammation	0.93920312
64	MP0003436_decreased_susceptibility_to	0.93620150
65	MP0002234_abnormal_pharynx_morphology	0.92754807
66	MP0006082_CNS_inflammation	0.91049676
67	MP0002736_abnormal_nociception_after	0.90635390
68	MP0008932_abnormal_embryonic_tissue	0.88800201
69	MP0002177_abnormal_outer_ear	0.88011042
70	MP0002452_abnormal_antigen_presenting	0.86428276
71	MP0001485_abnormal_pinna_reflex	0.85278964
72	MP0002102_abnormal_ear_morphology	0.83721598
73	MP0005025_abnormal_response_to	0.83548550
74	MP0003195_calcinosis	0.82940412
75	MP0005636_abnormal_mineral_homeostasis	0.82560463
76	MP0003186_abnormal_redox_activity	0.81962699
77	MP0010155_abnormal_intestine_physiology	0.81526088
78	MP0000579_abnormal_nail_morphology	0.81311832
79	MP0008775_abnormal_heart_ventricle	0.81248756
80	MP0004130_abnormal_muscle_cell	0.80751112
81	MP0000716_abnormal_immune_system	0.79367920
82	MP0005253_abnormal_eye_physiology	0.79268974
83	MP0004957_abnormal_blastocyst_morpholog	0.79004085
84	MP0005084_abnormal_gallbladder_morpholo	0.78344149
85	MP0006276_abnormal_autonomic_nervous	0.77330521
86	MP0003786_premature_aging	0.76632104
87	MP0002722_abnormal_immune_system	0.76193753
88	MP0003183_abnormal_peptide_metabolism	0.75757967
89	MP0000689_abnormal_spleen_morphology	0.74600921
90	MP0002429_abnormal_blood_cell	0.74274010
91	MP0003567_abnormal_fetal_cardiomyocyte	0.73078495
92	MP0002127_abnormal_cardiovascular_syste	0.72639702
93	MP0003136_yellow_coat_color	0.72238886
94	MP0001501_abnormal_sleep_pattern	0.71717303
95	MP0005645_abnormal_hypothalamus_physiol	0.70048404
96	MP0005332_abnormal_amino_acid	0.69951854
97	MP0004742_abnormal_vestibular_system	0.66740053
98	MP0000703_abnormal_thymus_morphology	0.65672559
99	MP0008873_increased_physiological_sensi	0.65554534
100	MP0009745_abnormal_behavioral_response	0.65326194

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Global brain atrophy (HP:0002283)	6.59997842
2	Hypobetalipoproteinemia (HP:0003563)	4.95304759
3	Acanthocytosis (HP:0001927)	4.62543886
4	Abnormality of the phalanges of the 2nd finger (HP:0009541)	4.58767993
5	Neurodegeneration (HP:0002180)	4.51960356
6	Akinesia (HP:0002304)	4.38836069
7	Methylmalonic acidemia (HP:0002912)	4.35009153
8	Patent foramen ovale (HP:0001655)	4.21984861
9	Microretrognathia (HP:0000308)	3.97308393
10	Dyskinesia (HP:0100660)	3.83300174
11	Mitochondrial inheritance (HP:0001427)	3.70805065
12	Hyperglycinemia (HP:0002154)	3.70630009
13	Increased CSF lactate (HP:0002490)	3.67000299
14	Broad distal phalanx of finger (HP:0009836)	3.61359220
15	Elevated erythrocyte sedimentation rate (HP:0003565)	3.50042329
16	Increased hepatocellular lipid droplets (HP:0006565)	3.49064596
17	Hepatocellular necrosis (HP:0001404)	3.37883892
18	Hepatic necrosis (HP:0002605)	3.30724347
19	Diminished movement (HP:0002374)	3.29032774
20	Abnormality of cells of the erythroid lineage (HP:0012130)	3.27618783
21	Acute necrotizing encephalopathy (HP:0006965)	3.25619716
22	Renal Fanconi syndrome (HP:0001994)	3.09559968
23	Methylmalonic aciduria (HP:0012120)	3.07550700
24	Macrocytic anemia (HP:0001972)	3.05313885
25	Increased intramyocellular lipid droplets (HP:0012240)	3.04575287
26	Dysphonia (HP:0001618)	3.04283908
27	Abnormal mitochondria in muscle tissue (HP:0008316)	3.00153711
28	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.97772035
29	3-Methylglutaconic aciduria (HP:0003535)	2.88511252
30	Abnormality of the basal ganglia (HP:0002134)	2.83946645
31	Lipid accumulation in hepatocytes (HP:0006561)	2.82783251
32	Large eyes (HP:0001090)	2.81223200
33	Abnormality of vitamin B metabolism (HP:0004340)	2.81175883
34	Pallor (HP:0000980)	2.79451853
35	Progressive macrocephaly (HP:0004481)	2.76441694
36	Abnormality of the 2nd finger (HP:0004100)	2.74182551
37	Congenital stationary night blindness (HP:0007642)	2.74137135
38	Respiratory difficulties (HP:0002880)	2.67139993
39	Acute encephalopathy (HP:0006846)	2.66462023
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.62957009
41	Abnormality of alanine metabolism (HP:0010916)	2.62957009
42	Hyperalaninemia (HP:0003348)	2.62957009
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.60429162
44	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.60429162
45	CNS demyelination (HP:0007305)	2.55504341
46	Exertional dyspnea (HP:0002875)	2.48768051
47	Partial duplication of the phalanx of hand (HP:0009999)	2.45812458
48	Decreased muscle mass (HP:0003199)	2.43643816
49	Amblyopia (HP:0000646)	2.38449741
50	Increased muscle lipid content (HP:0009058)	2.36737725
51	Delayed CNS myelination (HP:0002188)	2.32568824
52	Abnormal number of erythroid precursors (HP:0012131)	2.31995276
53	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.31174527
54	Parakeratosis (HP:0001036)	2.28787417
55	Increased serum lactate (HP:0002151)	2.28161703
56	Brushfield spots (HP:0001088)	2.25381594
57	Craniofacial dystonia (HP:0012179)	2.23718699
58	Tubulointerstitial nephritis (HP:0001970)	2.22612526
59	Congenital glaucoma (HP:0001087)	2.22216302
60	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.20348083
61	Abnormality of serum amino acid levels (HP:0003112)	2.16920125
62	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.16620051
63	Renal tubular dysfunction (HP:0000124)	2.15775753
64	Orchitis (HP:0100796)	2.11480647
65	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.10034520
66	Abnormality of renal resorption (HP:0011038)	2.09134755
67	Homocystinuria (HP:0002156)	2.08912192
68	Abnormality of homocysteine metabolism (HP:0010919)	2.08912192
69	Focal dystonia (HP:0004373)	2.07723384
70	Lactic acidosis (HP:0003128)	2.05816899
71	Abnormality of the phalanges of the hallux (HP:0010057)	2.04156700
72	Abnormality of the middle phalanges of the toes (HP:0010183)	2.03928913
73	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.02536820
74	Absent/shortened dynein arms (HP:0200106)	2.01915913
75	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.01915913
76	Myositis (HP:0100614)	1.99180789
77	Cleft eyelid (HP:0000625)	1.98830657
78	Esophageal neoplasm (HP:0100751)	1.98635456
79	Neoplasm of head and neck (HP:0012288)	1.98635456
80	Poikilocytosis (HP:0004447)	1.97932237
81	Stenosis of the external auditory canal (HP:0000402)	1.95649539
82	Renal cortical cysts (HP:0000803)	1.95180376
83	Cerebral edema (HP:0002181)	1.93737607
84	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.93472860
85	Paralysis (HP:0003470)	1.92668877
86	Long nose (HP:0003189)	1.92243786
87	Agitation (HP:0000713)	1.91073617
88	Respiratory failure (HP:0002878)	1.90261986
89	Hypoplasia of the pons (HP:0012110)	1.87976596
90	Abnormality of vitamin metabolism (HP:0100508)	1.87499540
91	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.86801885
92	Stomatitis (HP:0010280)	1.86377003
93	Bicuspid aortic valve (HP:0001647)	1.84274478
94	Dicarboxylic aciduria (HP:0003215)	1.84234460
95	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.84234460
96	Aplasia/hypoplasia of the uterus (HP:0008684)	1.82306518
97	Abnormal hemoglobin (HP:0011902)	1.80757847
98	Gliosis (HP:0002171)	1.80443018
99	Buphthalmos (HP:0000557)	1.80107807
100	Glycosuria (HP:0003076)	1.78599126

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	4.77780027
2	ERN1	4.54212484
3	NME2	3.33905455
4	TESK2	3.09269122
5	MAP2K6	2.71739333
6	MAP4K2	2.27355005
7	FRK	2.08548853
8	TXK	2.00593899
9	BCKDK	1.99772944
10	GRK1	1.86592695
11	NUAK1	1.85160327
12	PASK	1.84543898
13	MAP4K1	1.64420867
14	ADRBK2	1.52765402
15	PIM2	1.52703515
16	WNK4	1.49724804
17	KDR	1.47277824
18	CSF1R	1.43686810
19	ABL2	1.40656125
20	AKT2	1.40139407
21	ARAF	1.39996975
22	ZAK	1.38525648
23	VRK2	1.37193599
24	TLK1	1.37178269
25	LCK	1.36695303
26	BRAF	1.35829709
27	SYK	1.35496327
28	TAOK3	1.35332257
29	PINK1	1.34540337
30	EIF2AK1	1.33026136
31	TIE1	1.29226698
32	INSRR	1.27579978
33	FES	1.19010683
34	BMPR2	1.15490516
35	ZAP70	1.12517449
36	PIM1	1.11874799
37	WNK3	1.08080265
38	PIK3CA	1.07826152
39	ITK	1.05769956
40	RIPK4	1.04319071
41	TEC	1.03107953
42	RPS6KA5	1.01359802
43	IKBKB	0.97768306
44	PHKG2	0.97692216
45	PHKG1	0.97692216
46	SRPK1	0.96973165
47	STK16	0.96248832
48	OBSCN	0.95754623
49	PRKCQ	0.92213021
50	CSNK2A1	0.85737697
51	RPS6KA6	0.83008379
52	PKN1	0.82483899
53	STK3	0.80547649
54	NEK1	0.80468326
55	AURKA	0.80415628
56	PDK1	0.80006758
57	VRK1	0.77111903
58	RPS6KB1	0.76948568
59	PLK4	0.76364212
60	DYRK2	0.74947494
61	CAMKK2	0.74740277
62	MUSK	0.73633103
63	PDPK1	0.71528092
64	PRKCH	0.70359746
65	RPS6KC1	0.69351151
66	RPS6KL1	0.69351151
67	ADRBK1	0.69275337
68	CSNK2A2	0.68737368
69	LRRK2	0.66682521
70	PRKCD	0.63501587
71	TGFBR1	0.60350559
72	INSR	0.60112312
73	PRKCA	0.59821963
74	PRKACA	0.58630451
75	PRKCI	0.57276056
76	BTK	0.56441031
77	STK38	0.56383526
78	PRKCG	0.56299624
79	STK4	0.54539988
80	MAP2K2	0.52731661
81	RPS6KA2	0.52677179
82	CDK8	0.51790008
83	RPS6KA4	0.51516791
84	RPS6KA1	0.49699750
85	PRKD2	0.49030316
86	MAPKAPK3	0.48694917
87	BUB1	0.47786019
88	ILK	0.47536913
89	CAMK2A	0.47141166
90	ROCK2	0.46942712
91	ATR	0.46239820
92	LYN	0.45681187
93	MST4	0.40495223
94	TBK1	0.40474541
95	BMPR1B	0.38160509
96	CAMK2G	0.36789161
97	FYN	0.36480926
98	MAPK13	0.36163852
99	OXSR1	0.34992304
100	CDK4	0.34047150

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.41024585
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.17524306
3	Parkinsons disease_Homo sapiens_hsa05012	3.60219689
4	Caffeine metabolism_Homo sapiens_hsa00232	3.49022538
5	Sulfur metabolism_Homo sapiens_hsa00920	3.33296904
6	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.70351867
7	Alzheimers disease_Homo sapiens_hsa05010	2.47539515
8	Proteasome_Homo sapiens_hsa03050	2.34476951
9	Huntingtons disease_Homo sapiens_hsa05016	2.34395689
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.26024545
11	RNA degradation_Homo sapiens_hsa03018	2.12418124
12	Allograft rejection_Homo sapiens_hsa05330	2.00261156
13	RNA polymerase_Homo sapiens_hsa03020	2.00243801
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.94106240
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.90819110
16	Asthma_Homo sapiens_hsa05310	1.82883679
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.79870056
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.73667437
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.72208094
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.64315117
21	Sulfur relay system_Homo sapiens_hsa04122	1.64278971
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57303352
23	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.49642175
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.41395818
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.40243841
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.36925480
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.28872691
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.19363772
29	Homologous recombination_Homo sapiens_hsa03440	1.11667178
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.09940289
31	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.09078548
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.05651291
33	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.04907686
34	One carbon pool by folate_Homo sapiens_hsa00670	0.99791162
35	Protein export_Homo sapiens_hsa03060	0.98905486
36	Selenocompound metabolism_Homo sapiens_hsa00450	0.95561328
37	Tryptophan metabolism_Homo sapiens_hsa00380	0.92372481
38	Regulation of autophagy_Homo sapiens_hsa04140	0.90842354
39	Mismatch repair_Homo sapiens_hsa03430	0.90806291
40	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.86016809
41	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.85257664
42	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.83924357
43	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.81212832
44	DNA replication_Homo sapiens_hsa03030	0.79989374
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.79214721
46	Antigen processing and presentation_Homo sapiens_hsa04612	0.78038753
47	Phototransduction_Homo sapiens_hsa04744	0.77816388
48	Purine metabolism_Homo sapiens_hsa00230	0.77319557
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.77078008
50	Peroxisome_Homo sapiens_hsa04146	0.75275350
51	Spliceosome_Homo sapiens_hsa03040	0.74332981
52	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.73125456
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72639556
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72034301
55	Metabolic pathways_Homo sapiens_hsa01100	0.68907549
56	Rheumatoid arthritis_Homo sapiens_hsa05323	0.63385197
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63015516
58	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.62029195
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60447634
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60328520
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57893353
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.57873112
63	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.56904760
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56094508
65	Fanconi anemia pathway_Homo sapiens_hsa03460	0.55764222
66	Propanoate metabolism_Homo sapiens_hsa00640	0.55341889
67	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.52689163
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.51137128
69	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.50727529
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50678993
71	Basal transcription factors_Homo sapiens_hsa03022	0.50012070
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49247777
73	Malaria_Homo sapiens_hsa05144	0.46695384
74	Olfactory transduction_Homo sapiens_hsa04740	0.46139516
75	RNA transport_Homo sapiens_hsa03013	0.41192223
76	Base excision repair_Homo sapiens_hsa03410	0.40922616
77	Retinol metabolism_Homo sapiens_hsa00830	0.40659986
78	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.35611428
79	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35361530
80	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.34556948
81	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.32893598
82	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.31993983
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30504519
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.29897208
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.29139245
86	Viral myocarditis_Homo sapiens_hsa05416	0.28925147
87	Morphine addiction_Homo sapiens_hsa05032	0.27254306
88	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.27060602
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.25809469
90	Folate biosynthesis_Homo sapiens_hsa00790	0.25805241
91	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.25348146
92	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.25091035
93	Nicotine addiction_Homo sapiens_hsa05033	0.24158076
94	Leishmaniasis_Homo sapiens_hsa05140	0.24134664
95	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.23708073
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.19067742
97	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.16965532
98	Taste transduction_Homo sapiens_hsa04742	0.13321633
99	Serotonergic synapse_Homo sapiens_hsa04726	0.12111797
100	Butanoate metabolism_Homo sapiens_hsa00650	0.10198560

RPL23AP16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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