RPL23AP17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)9.72742294
2viral transcription (GO:0019083)8.52135036
3translational termination (GO:0006415)8.17026424
4activation of MAPKKK activity (GO:0000185)8.08293698
5positive regulation of signal transduction by p53 class mediator (GO:1901798)7.78014408
6regulation of activation of Janus kinase activity (GO:0010533)7.60405386
7regulation of memory T cell differentiation (GO:0043380)7.31174109
8pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.88954788
9translational elongation (GO:0006414)6.69072910
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.63630163
11positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)6.61871593
12leukocyte aggregation (GO:0070486)6.54238972
13protein targeting to ER (GO:0045047)6.48725202
14cotranslational protein targeting to membrane (GO:0006613)6.48347378
15cellular protein complex disassembly (GO:0043624)6.18485438
16establishment of protein localization to endoplasmic reticulum (GO:0072599)6.17949209
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.15581456
18regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)6.03657309
19protein localization to endoplasmic reticulum (GO:0070972)6.03452560
20pyrimidine nucleotide catabolic process (GO:0006244)5.96983145
21viral life cycle (GO:0019058)5.95749183
22ribosomal small subunit assembly (GO:0000028)5.73598259
23positive regulation of defense response to virus by host (GO:0002230)5.68973690
24nucleoside transmembrane transport (GO:1901642)5.42302568
25translational initiation (GO:0006413)5.34681804
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.06885039
27protein complex disassembly (GO:0043241)5.06347271
28chaperone-mediated protein transport (GO:0072321)4.98039343
29pseudouridine synthesis (GO:0001522)4.96917279
30glycoprotein catabolic process (GO:0006516)4.85090966
31regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)4.73770560
32macromolecular complex disassembly (GO:0032984)4.69914024
33pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.65097808
34rRNA transcription (GO:0009303)4.61645178
35positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.44556549
36protein targeting to membrane (GO:0006612)4.36908368
37positive regulation of cell fate commitment (GO:0010455)4.30002867
38DNA deamination (GO:0045006)4.18178648
39positive regulation of interleukin-17 production (GO:0032740)4.09982687
40erythrocyte maturation (GO:0043249)4.08737812
41maturation of SSU-rRNA (GO:0030490)4.06847142
42positive regulation of translational initiation (GO:0045948)4.04476719
43RNA localization (GO:0006403)4.03439963
44positive regulation of alpha-beta T cell proliferation (GO:0046641)3.98702570
45nuclear-transcribed mRNA catabolic process (GO:0000956)3.97520204
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.95854451
47ATP synthesis coupled proton transport (GO:0015986)3.95854451
48translation (GO:0006412)3.91302642
49positive regulation of T-helper 1 type immune response (GO:0002827)3.85873353
50nucleoside transport (GO:0015858)3.78487566
51regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.74791187
52male meiosis I (GO:0007141)3.73282536
53mRNA catabolic process (GO:0006402)3.70709211
54negative regulation of interleukin-10 production (GO:0032693)3.65635934
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.62127689
56protein complex biogenesis (GO:0070271)3.60870569
57regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.60634318
58positive regulation of T cell mediated cytotoxicity (GO:0001916)3.56490245
59negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.54272910
60maturation of 5.8S rRNA (GO:0000460)3.45513491
61rRNA metabolic process (GO:0016072)3.44516634
62cellular component biogenesis (GO:0044085)3.43158022
63SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.39935690
64deoxyribose phosphate biosynthetic process (GO:0046385)3.37714356
652-deoxyribonucleotide biosynthetic process (GO:0009265)3.37714356
66mitochondrial respiratory chain complex assembly (GO:0033108)3.35375978
67ribonucleoprotein complex biogenesis (GO:0022613)3.34740461
68peroxisome fission (GO:0016559)3.33599565
69induction of positive chemotaxis (GO:0050930)3.27842204
70RNA catabolic process (GO:0006401)3.24545359
71cytochrome complex assembly (GO:0017004)3.18914838
72positive regulation of vascular permeability (GO:0043117)3.15964826
73regulation of translation in response to stress (GO:0043555)3.10868173
74positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.09200790
75mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08751215
76synapsis (GO:0007129)3.07950360
77positive regulation of neutrophil chemotaxis (GO:0090023)3.06763190
78positive regulation of neutrophil migration (GO:1902624)3.06763190
79signal complex assembly (GO:0007172)3.01678723
80respiratory electron transport chain (GO:0022904)3.00972572
81electron transport chain (GO:0022900)2.99112668
82reciprocal meiotic recombination (GO:0007131)2.98726068
83reciprocal DNA recombination (GO:0035825)2.98726068
84regulation of defense response to virus by host (GO:0050691)2.98548295
85ribosomal large subunit biogenesis (GO:0042273)2.98076405
86deoxyribonucleotide catabolic process (GO:0009264)2.98045720
87rRNA processing (GO:0006364)2.93584197
88cellular response to gamma radiation (GO:0071480)2.92937103
89establishment of protein localization to membrane (GO:0090150)2.92921339
90regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.91202504
91transcription elongation from RNA polymerase I promoter (GO:0006362)2.90952628
92regulation of alpha-beta T cell proliferation (GO:0046640)2.87298395
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86328916
94mitochondrial respiratory chain complex I assembly (GO:0032981)2.86328916
95NADH dehydrogenase complex assembly (GO:0010257)2.86328916
96regulation of T cell mediated cytotoxicity (GO:0001914)2.79936471
97establishment of protein localization to mitochondrial membrane (GO:0090151)2.79573113
98deoxyribose phosphate catabolic process (GO:0046386)2.79047473
99positive regulation of T-helper cell differentiation (GO:0045624)2.77869115
100ribosomal small subunit biogenesis (GO:0042274)10.1910464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.87332476
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.74578266
3ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.56704707
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.02092598
5CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.71984932
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71881714
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71245787
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.65723390
9YY1_21170310_ChIP-Seq_MESCs_Mouse2.58337533
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.52251197
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36606777
12XRN2_22483619_ChIP-Seq_HELA_Human2.27062349
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26630137
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.23159510
15TAF2_19829295_ChIP-Seq_ESCs_Human2.14753593
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05147313
17STAT1_20625510_ChIP-Seq_HELA_Human2.00117183
18GATA1_26923725_Chip-Seq_HPCs_Mouse1.99469951
19CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.97951630
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95430553
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91368844
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85321530
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85115590
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85105568
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.82988372
26VDR_22108803_ChIP-Seq_LS180_Human1.82112892
27POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.81995886
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81101388
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76576194
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76018787
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68057927
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64128462
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.58707873
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53643835
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.53588155
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.53566863
37E2F1_20622854_ChIP-Seq_HELA_Human1.53230366
38VDR_21846776_ChIP-Seq_THP-1_Human1.51594907
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50844116
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49842615
41EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.49405066
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49056379
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45251402
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.43528751
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.39658001
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36689813
47RNF2_27304074_Chip-Seq_NSC_Mouse1.36644588
48CTCF_20526341_ChIP-Seq_ESCs_Human1.35377438
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.30806088
50SA1_27219007_Chip-Seq_Bcells_Human1.30787263
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28763593
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27539459
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27539459
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.27220298
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.26949944
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26421496
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25211877
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23081487
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22602347
60SOX2_21211035_ChIP-Seq_LN229_Human1.22578315
61SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21934267
62ERA_21632823_ChIP-Seq_H3396_Human1.20478856
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19181456
64NANOG_20526341_ChIP-Seq_ESCs_Human1.18915798
65RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18253381
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.16221894
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16023014
68P68_20966046_ChIP-Seq_HELA_Human1.15994805
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14129109
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.13904471
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12908212
72TTF2_22483619_ChIP-Seq_HELA_Human1.12843290
73YY1_22570637_ChIP-Seq_MALME-3M_Human1.12132172
74FOXP1_21924763_ChIP-Seq_HESCs_Human1.10751878
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.09766062
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09273857
77CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08500738
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08262732
79NCOR_22424771_ChIP-Seq_293T_Human1.05353556
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05181877
81STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04345421
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.04306638
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03455028
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03128781
85AR_20517297_ChIP-Seq_VCAP_Human1.02911339
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02906555
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.02119281
88ZNF274_21170338_ChIP-Seq_K562_Hela1.02006090
89CTCF_21964334_Chip-Seq_Bcells_Human1.00811606
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00174278
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00154153
92KDM5A_27292631_Chip-Seq_BREAST_Human1.00149118
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99724551
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98878928
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97255469
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96074191
97VDR_23849224_ChIP-Seq_CD4+_Human0.95640173
98MYC_22102868_ChIP-Seq_BL_Human0.95297309
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95207223
100ZNF263_19887448_ChIP-Seq_K562_Human0.94179905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology8.86640146
2MP0000750_abnormal_muscle_regeneration3.80439142
3MP0009379_abnormal_foot_pigmentation3.43285341
4MP0009384_cardiac_valve_regurgitation3.29645440
5MP0002638_abnormal_pupillary_reflex2.78750173
6MP0002163_abnormal_gland_morphology2.67345843
7MP0008875_abnormal_xenobiotic_pharmacok2.63742830
8MP0005671_abnormal_response_to2.61053117
9MP0002938_white_spotting2.56949368
10MP0005360_urolithiasis2.53779715
11MP0000858_altered_metastatic_potential2.41045223
12MP0004885_abnormal_endolymph2.38552339
13MP0000013_abnormal_adipose_tissue2.36928507
14MP0002160_abnormal_reproductive_system2.27258787
15MP0002277_abnormal_respiratory_mucosa2.23602931
16MP0003786_premature_aging2.20755481
17MP0000762_abnormal_tongue_morphology2.12678405
18MP0003646_muscle_fatigue1.91311245
19MP0002876_abnormal_thyroid_physiology1.85222690
20MP0009046_muscle_twitch1.84404796
21MP0002132_abnormal_respiratory_system1.78440612
22MP0009765_abnormal_xenobiotic_induced1.77520259
23MP0006292_abnormal_olfactory_placode1.77083288
24MP0005503_abnormal_tendon_morphology1.75809430
25MP0004130_abnormal_muscle_cell1.75777950
26MP0005379_endocrine/exocrine_gland_phen1.75315452
27MP0009785_altered_susceptibility_to1.72979615
28MP0005389_reproductive_system_phenotype1.66270662
29MP0000343_altered_response_to1.63851228
30MP0003303_peritoneal_inflammation1.61590191
31MP0001661_extended_life_span1.58996633
32MP0004147_increased_porphyrin_level1.58386049
33MP0001984_abnormal_olfaction1.57264108
34MP0010307_abnormal_tumor_latency1.54064608
35MP0004145_abnormal_muscle_electrophysio1.39747666
36MP0003385_abnormal_body_wall1.39140084
37MP0002837_dystrophic_cardiac_calcinosis1.38294403
38MP0000372_irregular_coat_pigmentation1.34029391
39MP0004947_skin_inflammation1.25748294
40MP0005410_abnormal_fertilization1.24901316
41MP0005085_abnormal_gallbladder_physiolo1.19585266
42MP0005551_abnormal_eye_electrophysiolog1.16148062
43MP0000678_abnormal_parathyroid_gland1.16014069
44MP0002102_abnormal_ear_morphology1.15146701
45MP0010386_abnormal_urinary_bladder1.11915750
46MP0005646_abnormal_pituitary_gland1.10439733
47MP0003195_calcinosis1.04955749
48MP0003866_abnormal_defecation1.01852785
49MP0002177_abnormal_outer_ear1.01329873
50MP0005000_abnormal_immune_tolerance0.99871788
51MP0003011_delayed_dark_adaptation0.98432155
52MP0005377_hearing/vestibular/ear_phenot0.98400803
53MP0003878_abnormal_ear_physiology0.98400803
54MP0010155_abnormal_intestine_physiology0.96585250
55MP0009250_abnormal_appendicular_skeleto0.96243813
56MP0001800_abnormal_humoral_immune0.94167596
57MP0003436_decreased_susceptibility_to0.91848401
58MP0000049_abnormal_middle_ear0.91688353
59MP0001790_abnormal_immune_system0.90566846
60MP0005387_immune_system_phenotype0.90566846
61MP0003137_abnormal_impulse_conducting0.87540849
62MP0004142_abnormal_muscle_tone0.87057691
63MP0005332_abnormal_amino_acid0.84815984
64MP0003252_abnormal_bile_duct0.83480806
65MP0000631_abnormal_neuroendocrine_gland0.83379833
66MP0002249_abnormal_larynx_morphology0.83104401
67MP0009745_abnormal_behavioral_response0.80388947
68MP0005647_abnormal_sex_gland0.79212881
69MP0001188_hyperpigmentation0.77252518
70MP0008775_abnormal_heart_ventricle0.75252875
71MP0005584_abnormal_enzyme/coenzyme_acti0.72547764
72MP0008872_abnormal_physiological_respon0.72183088
73MP0002148_abnormal_hypersensitivity_rea0.70564098
74MP0005187_abnormal_penis_morphology0.70101340
75MP0002067_abnormal_sensory_capabilities0.67467458
76MP0002933_joint_inflammation0.67339345
77MP0001919_abnormal_reproductive_system0.66636926
78MP0003186_abnormal_redox_activity0.65355696
79MP0004858_abnormal_nervous_system0.65197445
80MP0009764_decreased_sensitivity_to0.64975089
81MP0003136_yellow_coat_color0.64669382
82MP0005636_abnormal_mineral_homeostasis0.64528192
83MP0009763_increased_sensitivity_to0.63836375
84MP0001881_abnormal_mammary_gland0.63802874
85MP0003315_abnormal_perineum_morphology0.63392183
86MP0002108_abnormal_muscle_morphology0.62736636
87MP0002822_catalepsy0.61800283
88MP0003115_abnormal_respiratory_system0.61737197
89MP0008770_decreased_survivor_rate0.59976394
90MP0002019_abnormal_tumor_incidence0.59787418
91MP0003279_aneurysm0.59672189
92MP0006036_abnormal_mitochondrial_physio0.59060704
93MP0009333_abnormal_splenocyte_physiolog0.58750119
94MP0002269_muscular_atrophy0.57284678
95MP0002723_abnormal_immune_serum0.56529101
96MP0008058_abnormal_DNA_repair0.55492952
97MP0003755_abnormal_palate_morphology0.54941671
98MP0001542_abnormal_bone_strength0.52939768
99MP0003763_abnormal_thymus_physiology0.52470153
100MP0001835_abnormal_antigen_presentation0.52169009

Predicted human phenotypes

RankGene SetZ-score
1Retinal atrophy (HP:0001105)8.96915263
2Cerebellar dysplasia (HP:0007033)8.32196911
3Type II lissencephaly (HP:0007260)8.13958242
4Retinal dysplasia (HP:0007973)7.30480741
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.92599676
6Hypoplasia of the pons (HP:0012110)6.36565001
7Difficulty climbing stairs (HP:0003551)6.05728260
8Decreased electroretinogram (ERG) amplitude (HP:0000654)5.99959421
9Aplasia/Hypoplasia affecting the retina (HP:0008061)5.95769341
10Fatigue (HP:0012378)5.93963764
11Abnormality of the pons (HP:0007361)5.65603279
12Fragile nails (HP:0001808)5.43436738
13Decreased subcutaneous fat (HP:0001002)5.26661143
14Buphthalmos (HP:0000557)5.21909732
15Erythroderma (HP:0001019)4.41030941
16Congenital ichthyosiform erythroderma (HP:0007431)4.23233719
17Pallor (HP:0000980)4.20700112
18Brittle hair (HP:0002299)4.14696597
19IgG deficiency (HP:0004315)3.93733749
20Abnormality of subcutaneous fat tissue (HP:0001001)3.90903034
21Abolished electroretinogram (ERG) (HP:0000550)3.74524153
22Severe muscular hypotonia (HP:0006829)3.53067307
23Cerebral hypomyelination (HP:0006808)3.32900925
24Megalocornea (HP:0000485)3.29845680
25Congenital glaucoma (HP:0001087)3.07399250
26Generalized hypotonia (HP:0001290)2.94831306
27Macrocytic anemia (HP:0001972)2.93502133
28Submucous cleft hard palate (HP:0000176)2.65669344
29Entropion (HP:0000621)2.64653236
30Severe global developmental delay (HP:0011344)2.52139756
31Acute necrotizing encephalopathy (HP:0006965)2.48437002
32Gowers sign (HP:0003391)2.36529506
33Conjugated hyperbilirubinemia (HP:0002908)2.36444001
34Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.31414070
35Generalized muscle weakness (HP:0003324)2.28749468
36Non-midline cleft lip (HP:0100335)2.28734490
37Abnormal mitochondria in muscle tissue (HP:0008316)2.24617884
38Lissencephaly (HP:0001339)2.24133360
39Abnormality of the vitreous humor (HP:0004327)2.19408584
40Mesangial abnormality (HP:0001966)2.15885429
41Concave nail (HP:0001598)2.14894858
42Papilledema (HP:0001085)2.11746183
43Meningocele (HP:0002435)2.10856725
443-Methylglutaconic aciduria (HP:0003535)2.08067183
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.03470108
46Absent/shortened dynein arms (HP:0200106)2.03470108
47Abnormality of DNA repair (HP:0003254)2.03275823
48Congenital sensorineural hearing impairment (HP:0008527)2.01570702
49Poikiloderma (HP:0001029)2.00490558
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98189992
51Abnormality of alanine metabolism (HP:0010916)1.98189992
52Hyperalaninemia (HP:0003348)1.98189992
53Acute encephalopathy (HP:0006846)1.97680642
54Progressive macrocephaly (HP:0004481)1.97545602
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97332127
56Esophageal neoplasm (HP:0100751)1.97125623
57Neoplasm of head and neck (HP:0012288)1.97125623
58Ileus (HP:0002595)1.93186367
59Mitochondrial inheritance (HP:0001427)1.88138378
60Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87791289
61Hypoplasia of the brainstem (HP:0002365)1.87791289
62Cellular immunodeficiency (HP:0005374)1.85085206
63Depressed nasal tip (HP:0000437)1.79313970
64Retrobulbar optic neuritis (HP:0100654)1.79220501
65Optic neuritis (HP:0100653)1.79220501
66Pachygyria (HP:0001302)1.78269083
67IgM deficiency (HP:0002850)1.77910116
68Slow saccadic eye movements (HP:0000514)1.75980395
69Keratitis (HP:0000491)1.75973103
70Congenital stationary night blindness (HP:0007642)1.74661915
71Abnormality of vision evoked potentials (HP:0000649)1.73046215
72Unsteady gait (HP:0002317)1.70480297
73Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69350095
74Abnormal number of erythroid precursors (HP:0012131)1.69015827
75Dysphonia (HP:0001618)1.68668916
76Increased serum pyruvate (HP:0003542)1.67459669
77Increased CSF lactate (HP:0002490)1.65396519
78Abnormality of cells of the erythroid lineage (HP:0012130)1.63511206
79Intellectual disability, profound (HP:0002187)1.62866638
80Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.62442713
81Decreased activity of mitochondrial respiratory chain (HP:0008972)1.62442713
82Hypoplasia of the radius (HP:0002984)1.60439678
83Nausea (HP:0002018)1.59981637
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.59531962
85Degeneration of the lateral corticospinal tracts (HP:0002314)1.59531962
86Rectal prolapse (HP:0002035)1.54700040
87Elevated erythrocyte sedimentation rate (HP:0003565)1.53320099
88Muscular dystrophy (HP:0003560)1.53311170
89Holoprosencephaly (HP:0001360)1.51199129
90Increased IgM level (HP:0003496)1.51048881
91Parakeratosis (HP:0001036)1.48292149
92CNS hypomyelination (HP:0003429)1.44989807
93Premature ovarian failure (HP:0008209)1.44319373
94Chronic bronchitis (HP:0004469)1.42618360
95Delusions (HP:0000746)1.42615836
96Absent thumb (HP:0009777)1.42520256
97Orchitis (HP:0100796)1.41050954
98Asthma (HP:0002099)1.39451773
99Polymicrogyria (HP:0002126)1.37717944
100Muscle stiffness (HP:0003552)1.37148588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK36.83200420
2STK106.40510510
3RIPK15.64732377
4NME23.22911563
5STK112.94651285
6PIM12.70268735
7PRKCI2.52210693
8ICK2.36943209
9MAP3K132.30537486
10ARAF2.21176867
11TXK2.17650225
12MAP4K12.03439930
13MAP3K91.94337291
14ERN11.93986416
15PTK2B1.86314504
16LMTK21.70357475
17ADRBK21.63078477
18CDK191.55233408
19PASK1.49120503
20PRKCG1.44097533
21PDPK11.23089644
22BMPR21.21298608
23BRAF1.14591296
24AKT31.09042721
25ADRBK11.07621169
26KDR1.07076798
27PRKCE1.04424742
28MOS1.03016800
29NEK10.99668008
30MAPKAPK30.98898790
31ITK0.97554587
32OBSCN0.96977197
33PRKCH0.94984362
34CAMKK20.90832982
35JAK30.85961258
36PRKCD0.85712830
37CLK10.85626876
38BCKDK0.81537066
39INSRR0.74342952
40MAP2K20.73216277
41CSK0.71612937
42PDK20.70557289
43LRRK20.69494498
44NLK0.69422484
45GRK10.68738470
46PRKCZ0.68001981
47EEF2K0.66975030
48PLK40.66731910
49IKBKB0.64960116
50ILK0.64744553
51PIM20.63279398
52CAMKK10.60084735
53MUSK0.59810015
54PTK60.59023309
55PRKG20.56840363
56RPS6KA50.55949798
57MAP4K20.55652767
58DAPK30.54576300
59RPS6KB20.52221174
60STK40.52122708
61STK30.51566681
62FYN0.49515571
63CSNK2A20.46318720
64TIE10.46125597
65YES10.46085662
66LCK0.45471371
67NME10.44717119
68KSR20.43206720
69GSK3A0.40268420
70MAPK150.39640972
71CSNK2A10.37605880
72GRK70.37405862
73PKN10.34644721
74PRKCB0.33788839
75TEC0.33412070
76MAPKAPK50.33003671
77WNK30.32805187
78TAOK10.32355538
79TAOK20.32166779
80MATK0.31006602
81PINK10.30793945
82CDK70.30699023
83PRKCA0.30350177
84TLK10.29819129
85FRK0.29484488
86CSNK1D0.26877442
87SYK0.26235720
88CAMK2B0.24041147
89PRKACA0.22242909
90WNK10.21880740
91ABL20.21714442
92MST1R0.21150924
93AKT20.20872251
94MAP3K80.20090733
95MTOR0.19996982
96CAMK2G0.19072903
97FES0.16977142
98LYN0.16925518
99PRKCQ0.16796899
100CDK11A0.16508554

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030108.14574435
2Oxidative phosphorylation_Homo sapiens_hsa001903.92935576
3Other types of O-glycan biosynthesis_Homo sapiens_hsa005143.48029707
4Parkinsons disease_Homo sapiens_hsa050123.19349544
5Sulfur relay system_Homo sapiens_hsa041223.06968537
6Huntingtons disease_Homo sapiens_hsa050162.26336896
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.18662983
8RNA polymerase_Homo sapiens_hsa030202.10928745
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10337101
10Alzheimers disease_Homo sapiens_hsa050102.07815970
11Tyrosine metabolism_Homo sapiens_hsa003501.98865363
12Cardiac muscle contraction_Homo sapiens_hsa042601.93097939
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86243064
14Pyrimidine metabolism_Homo sapiens_hsa002401.85615487
15Nucleotide excision repair_Homo sapiens_hsa034201.85003570
16Graft-versus-host disease_Homo sapiens_hsa053321.73821344
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.51641356
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48644618
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31465346
20Asthma_Homo sapiens_hsa053101.19079004
21Basal transcription factors_Homo sapiens_hsa030221.18145884
22Allograft rejection_Homo sapiens_hsa053301.17912427
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17400371
24Autoimmune thyroid disease_Homo sapiens_hsa053201.16255036
25Primary immunodeficiency_Homo sapiens_hsa053401.15193796
26Leishmaniasis_Homo sapiens_hsa051401.13955647
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12108463
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10748545
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.09793171
30Regulation of autophagy_Homo sapiens_hsa041401.08076904
31Rheumatoid arthritis_Homo sapiens_hsa053231.07631434
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04522839
33Sulfur metabolism_Homo sapiens_hsa009201.03421196
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02132475
35mTOR signaling pathway_Homo sapiens_hsa041500.91196446
36Collecting duct acid secretion_Homo sapiens_hsa049660.90646071
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87649488
38RNA degradation_Homo sapiens_hsa030180.87454985
39DNA replication_Homo sapiens_hsa030300.84042821
40Malaria_Homo sapiens_hsa051440.82925592
41Olfactory transduction_Homo sapiens_hsa047400.82836976
42Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80281000
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73973259
44Fat digestion and absorption_Homo sapiens_hsa049750.71294706
45Type I diabetes mellitus_Homo sapiens_hsa049400.68988893
46Antigen processing and presentation_Homo sapiens_hsa046120.67201091
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65666831
48Bile secretion_Homo sapiens_hsa049760.65618649
49Protein export_Homo sapiens_hsa030600.64687482
50One carbon pool by folate_Homo sapiens_hsa006700.64320080
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.63341396
52Purine metabolism_Homo sapiens_hsa002300.63248069
53Acute myeloid leukemia_Homo sapiens_hsa052210.62142932
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61901177
55Hematopoietic cell lineage_Homo sapiens_hsa046400.61240028
56Retinol metabolism_Homo sapiens_hsa008300.60948809
57Phototransduction_Homo sapiens_hsa047440.60440944
58Protein digestion and absorption_Homo sapiens_hsa049740.59841311
59Systemic lupus erythematosus_Homo sapiens_hsa053220.59307804
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58907270
61Toxoplasmosis_Homo sapiens_hsa051450.58188836
62Peroxisome_Homo sapiens_hsa041460.58019303
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57125758
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56341786
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56265264
66Staphylococcus aureus infection_Homo sapiens_hsa051500.54664359
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.53684488
68Metabolic pathways_Homo sapiens_hsa011000.53359752
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.53089033
70TNF signaling pathway_Homo sapiens_hsa046680.52913264
71Chemical carcinogenesis_Homo sapiens_hsa052040.52273456
72Nitrogen metabolism_Homo sapiens_hsa009100.52086919
73Phenylalanine metabolism_Homo sapiens_hsa003600.50576868
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50332171
75Pertussis_Homo sapiens_hsa051330.46981168
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44199828
77Glycerolipid metabolism_Homo sapiens_hsa005610.42525693
78Mineral absorption_Homo sapiens_hsa049780.41212019
79Base excision repair_Homo sapiens_hsa034100.38700879
80Spliceosome_Homo sapiens_hsa030400.34664321
81AMPK signaling pathway_Homo sapiens_hsa041520.33947563
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32083653
83Linoleic acid metabolism_Homo sapiens_hsa005910.30489140
84Proteasome_Homo sapiens_hsa030500.30167849
85Prion diseases_Homo sapiens_hsa050200.30126079
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28527760
87Tryptophan metabolism_Homo sapiens_hsa003800.27974095
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.27297409
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.25588748
90Phagosome_Homo sapiens_hsa041450.23607427
91Epstein-Barr virus infection_Homo sapiens_hsa051690.22412245
92Fatty acid degradation_Homo sapiens_hsa000710.22137399
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21991186
94Morphine addiction_Homo sapiens_hsa050320.21943921
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21819497
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.19640577
97Fanconi anemia pathway_Homo sapiens_hsa034600.19562397
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18805961
99Fatty acid metabolism_Homo sapiens_hsa012120.18803896
100RNA transport_Homo sapiens_hsa030130.17686710

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